Znosko, 1
BRENT M. ZNOSKO
Assistant Professor of Chemistry
Department of Chemistry
Saint Louis University
Saint Louis, MO 63103
Phone: (314) 977-8567
Email: znoskob@slu.edu
Fax: (314) 977-2521
EDUCATION
Ph.D., Chemistry, University of Rochester, NY. June 2004.
Dissertation: Thermodynamic and Structural Properties of RNA Oligomers Containing Purine Rich
Internal Loops and DNA:RNA Hybrids with C5-Propynyl Substitutions.
Advisor: Prof. Douglas Turner.
M.S., Chemistry, University of Rochester, NY. May 2001.
Curriculum: Quantum Mechanics, Thermodynamics & Statistical Mechanics, Biophysical
Chemistry I & II, Special Topics in RNA. Other courses attended: Computational Chemistry,
Preparing for Academic Careers in Engineering and Science.
B.S., Chemistry (magna cum laude) with Honors, Allegheny College, Meadville, PA May 1999.
Senior Research: Thermodynamics of single nucleotide bulges in RNA duplexes.
Advisor: Prof. Martin Serra.
PUBLICATIONS
Chen, G., Znosko, B. M., Kennedy, S. D., Krugh, T. R., and Turner, D. H. (2005) Solution structure
of an RNA internal loop with three consecutive sheared GA pairs. Biochemistry 44, 2845-2856.
Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. (2004) Structural
features and thermodynamics of the J4/5 loop from the Candida albicans and Candida dubliniensis
group I introns. Biochemistry 43, 15822-15837.
Chen, G., Znosko, B. M., Jiao, X., and Turner, D. H. (2004) Factors affecting thermodynamic
stabilities of RNA 3x3 internal loops. Biochemistry 43, 12865-12876.
Znosko, B. M., Barnes T. W., Krugh T. R., and Turner, D. H. (2003) NMR studies of DNA single
strands and DNA:RNA hybrids with and without 1-propynylation at C5 of oligopyrimidines. J. Am.
Chem. Soc. 125, 6090-6097.
Znosko, B. M., Burkard, M. E., Krugh, T. R., and Turner, D. H. (2002) Molecular recognition in
purine-rich internal loops: Thermodynamic, structural, and dynamic consequences of purine for
adenine substitutions in 5’(rGGCAAGCCU)2. Biochemistry 41, 14978-14987.
Znosko, B. M., Burkard, M. E., Schroeder, S. J., Krugh, T. R., and Turner, D. H. (2002) Sheared
AantiAanti base pairs in a destabilizing 2x2 internal loop: The NMR structure of
5’(rGGCAAGCCU)2. Biochemistry 41, 14969-14977.
Znosko, 2
Znosko, B. M., Silvestri, S. B., Volkman, H., Boswell, B., and Serra, M. J. (2002) Thermodynamic
parameters for an expanded nearest-neighbor model for the formation of RNA duplexes with single
nucleotide bulges. Biochemistry 41, 10406-10417.
ABSTRACTS AND PRESENTATIONS (Presenters are underlined and undergraduates are
asterisked.)
Wright, D. J.*, Rice, J. L.*, and Znosko, B. M. Thermodynamic parameters of RNA duplexes
containing inosine. RNA 2005: Tenth Annual Meeting of the RNA Society (Poster).
Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. Structural features and
thermodynamics of the J4/5 loop from the Candida albicans group I intron. RNA 2005: Tenth
Annual Meeting of the RNA Society (Poster).
Wright, D. J.*, Rice, J. L.*, and Znosko, B. M. Thermodynamic parameters of RNA duplexes
containing inosine. Nucleic Acid Gordon Conference (Poster).
Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. Structural features and
thermodynamics of the J4/5 loop from the Candida albicans group I intron. Nucleic Acid Gordon
Conference (Poster).
Wright, D. J.*, Rice, J. L.*, and Znosko, B. M. Thermodynamic parameters of RNA duplexes
containing inosine. 2005 Undergraduate Research Symposium sponsored by the St. Louis Section of
the ACS. Awarded first place in the poster category (Poster).
Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. Structural features and
thermodynamics of the J4/5 loop from the Candida albicans intron. Saint Louis University Biology
Department 2005 Seminar (Talk).
Chen, G., Znosko, B.M., Kennedy, S.D., Jiao, X., Krugh, T.R., and Turner, D.H. Improved
Thermodynamic Model for Predicting RNA 3 X 3 Internal Loops and NMR Structure of an
Unusually Stable Loop with Three Consecutive Sheared GA Pairs. 2004 Biological Chemistry
Cluster in Department of Chemistry (Poster).
Znosko, B. M., Kennedy, S. D., Wille, P. C., Krugh, T. R., and Turner, D. H. Structural features and
thermodynamics of the J4/5 loop from the Candida albicans intron. Sigma Xi Saint Louis
University Chapter Fall 2004 Research Symposium (Poster).
Ferrin-O’Connell, I., Bellows, B., Znosko, B. M., Grover, N., and Turner, D. H. Examining the
thermodynamic stability and metal binding properties of domain II of the hammerhead ribozyme.
2004 Nucleic Acid Gordon Conference (Poster).
Ferrin-O'Connell, I., Znosko, B. M., Grover, N., and Turner, D. H. Thermodynamics of hammerhead
domain II oligonucleotide mimics. 2003 Rochester Research Experience for Undergraduates Poster
Session (Poster).
Wille, P., Znosko, B. M., Krugh, T. R., and Turner, D. H. Thermodynamic and structural
Znosko, 3
determination of the Candida albicans 2x2 internal loop. 2003 Rochester Research Experience for
Undergraduates Poster Session (Poster).
Znosko, B. M., Barnes, T. W., Krugh, T. R., and Turner, D. H. NMR studies of DNA single strands
and DNA:RNA hybrids with and without 1-propynylation at C5 of oligopyrimidines. Upstate New
York Structural Biology Day 2003 (Talk).
Znosko, B. M., Burkard, M. E., Barnes, T. W., Schroeder, S. J., Krugh, T. R., and Turner, D. H.
Providing structural insights into the thermodynamics of oligonucleotides: Purine-rich internal loops
and propynylated systems. 2002 Rochester Biophysical Seminar (Talk).
Znosko, B. M. Thermodynamic and structural studies of purine rich internal loops. Rochester RNA
Structure and Function Cluster Meeting 2002 (Talk).
Serra, M. J., Silvestri, S. B., Volkman, H., Boswell, B., and Znosko B. M. Thermodynamic
parameters for RNA bulge formation. 2002 National Meeting of the American Chemical Society
(Poster).
Skelly, K., Znosko, B. M., Krugh, T. R. Synthesis and thermodynamics of six-nucleotide RNA
hairpin loops. 2001 Rochester Research Experience for Undergraduates Poster Session (Poster).
Znosko, B. M., and Serra, M. J. Thermodynamics of single nucleotide bulges in RNA duplexes.
1999 National Conference of Undergraduate Research (Poster).
HONORS AND AWARDS
• SLU Summer Research Award, 7/05-9/05.
• First place awarded to Daniel J. Wright, Jamie L. Rice, and Brent M. Znosko for the poster
presentation “Thermodynamic parameters of RNA duplexes containing inosine” at the 2005
Undergraduate Research Symposium sponsored by the St. Louis Section of the ACS, 5/05.
• LI-COR Biosciences Genomics Education Matching Fund, 3/05.
• SLU Beaumont Faculty Development Fund, 1/05-12/05.
• W. D. Walters Teaching Award, 4/04.
• Agnes M. and George Messersmith Fellowship (awarded by the Dean to 2 students per year
campus-wide), 9/03-7/04.
• Oral Cellular and Molecular Biology Training Grant Trainee (declined), 9/03.
• Elon Huntington Hooker Graduate Fellowship (awarded by the Dean to 5 students per year campuswide), 9/02-9/03.
• Sherman Clarke Fellowship, 9/99-7/04.
• Allegheny Alden Scholar, 9/95-5/98, Distinguished Alden Scholar, 9/98-5/99.
• PPG Industries Foundation Community Scholarship, 9/95-5/99.
• Allegheny Presidential Merit Scholarship, 9/95-5/99.