Learning Guide for Acute Renal Failure/Kidney Trauma CMJ and LC 1. What are the functions of the kidney? Name at least 6: 2. The kidney regulates acid-base balance of HCO3 and ___+. (name the ion). Explain why metabolic acidosis develops in renal failure. Why does Kussmaul breathing occur? 3. Bonus question; what role do prostaglandins play in renal disease and hypertension and why? What category of drugs inhibit prostaglandin synthesis and thus may effect renal function (even lead to renal failure)? 4. Where is erythropoietin produced? What effect does ARF have on erythropoietin production? What lab values do you expect to be altered? 5. Activated Vitamin D is necessary to absorb Calcium in GI tract. If a client has ARF, what usual changes are seen in the client’s serum calcium level? Why does this occur? 6. (Review) Compare/contrast the following disease processes: Lewis pp. 1166-1169; 1176-1177 Disorder Acute Poststreptococcal Glomerulonephritis Rapidly progressive Glomerulonephritis Caused by/Manifestation Usual Treatment Chronic Glomerulonephritis Nephrotic Syndrome RNSG 2432 463 7. Vascular Disorders of the Kidneys: What percentage of the cardiac output do the kidneys receive? ______. What is the pathophysiology of hypertension that leads to renal failure? Explain why blood pressure control is important in preventing renal failure. Why is proteinuria seen in HTN? 8. What are several risk factors for renal vein stenosis/thrombosis? What are some common manifestations/complications of renal vein stenosis/thrombosis? 9. Renal artery stenosis: What is the most common manifestations/complication of renal artery stenosis? 10. Renal trauma: Why is the H&H important when there is renal trauma? What is Turner’s sign? Describe the usual management of renal trauma. 11. Renal surgery: Nephrectomy Why is TCDB & use of incentive spirometry important post-op? 12. Define acute renal failure. What is acute tubular necrosis? 13. Complete the table to compare/contrast the various types of ARF: Type Pre-renal Cause/Management of Acute Renal Failure Caused by Key Features Intra-renal Post-renal RNSG 2432 464 14. What lab test most accurately reflects renal function and how is it determined? 15. What is the normal serum phosphorus level? level? What is the normal serum calcium Explain why these values are altered when a client has acute renal failure. How are these alterations “managed”…include diet, medications? 16. Stages in ARF/Laboratory Studies/Priority Actions Typical onset & duration Most critical lab ARF Stages results Priority management Issues Initiating Phase Oliguric Phase Diuretic Phase Recovery Phase 17. How is fluid managed in acute renal failure once vascular volume and renal perfusion has been restored. What formula is used to ensure that the client does not become fluid overloaded (if fluid restriction the formula is 600ml + previous 24 hour fluid loss) 18. Why would a “fluid challenge” be used when a client is first discovered to have acute renal failure (may be anuric or oliguric)? Why would Dopamine be given IV and what effect would it have on the on the kidneys? 19. What is Kayexalate and when would this be used? 20. Name some phosphate binders. When should phosphate binders be given and why? RNSG 2432 465 21. Why would Epogen/Procrit sc be ordered? 22. Why is a diet low in protein usually indicated for the client with renal failure? RNSG 2432 466