Investigator-Initiated Research
2013 Study Activity and Outcomes
Year-to-Date as of September 2013
Patient-Related Outcomes
1. The Predictive Value of Her2/neu in Patients with DCIS and Other High Risk Breast Lesions:
A Case-Control Study. The overall goal of the investigator’s proposed study is to examine whether
overexpression of Her2/neu is a predictor of clinical outcomes in patients with Ductal Carcinoma in
situ (DCIS) and other high risk breast lesions including Lobular Carcinoma in situ (LCIS), Atypical
Ductal Hyperplasia (ADH) and Atypical Lobular Hyperplasia (ALH). The research team is currently
testing the hypothesis that Her2/neu overexpression in the above mentioned breast lesions may be
a reliable predictor of local recurrence of carcinoma, or an indicator of future cancer in a patient who
presents with an initial diagnosis of LCIS or an atypical lesion. Using tissue blocks from the ADH
and ALH patient cohorts, they have validated diagnosis, and stained the tissue for Her2/neu
expression. Subsequently, the team will analyze the data to examine the correlation of Her2/neu
overexpression to future risk of developing cancerous lesions.
PI: Judy Tjoe, MD; Co-I: Sanjay Kansra, PhD
2. Anti-Coagulant Pharmacogenetic Clinical Trial Simulations to Predict Improved Patient
Outcomes
The study has developed a normalized “anticoagulation” database containing more than 157,000
unique patients treated with warfarin. This database provides an invaluable resource for research
on developing algorithms supporting health providers in determining safe warfarin dosing for
individual patients more quickly.
Co-PIs: Michael Michalkiewicz, PhD, and Peter Tonellato, PhD, University of WisconsinMilwaukee
3. Determining the incidence and factors of cardiotoxicity in breast cancer patients treated with
anthracycline and/or Trastuzumab-containing regimen at Aurora Health Care by developing
in house natural language processing software
The study has gathered 2011 year data and identified 17 patients (with post-LVEF lower than 50%)
who fall into chemotherapy-induced-cardiotoxicity category as defined in the proposal. We have
completed extensive review of these 17 patients’ physician notes (majority over 100 pages)
obtained from patient charts to capture all the terms for the symptoms that are associated
cardiotoxicity, which established the foundation for building the NLP tool.
Based on these 17 notes from the identified cardiotoxicity cases from year 2011, we were able to
build a proto-type NLP tool, which has the ability to identify, search, highlight all the terms we are
interested and associated with cardiotoxicity. This tool has the following features:
It
is
webbased and can be run by any devices, such as PCs, smart phones, and tablets that have a browser.
Furthermore, this allows the UWM and Aurora researchers to work more efficiently during iterations
to refine the search tool. It provides a predesigned search option based on domain knowledge
provided by Aurora researchers. This allows a user to search for files without having to come up
with words or phrases to characterize cardiac toxicity side effects related to breast cancer
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treatments. It also provides a user input option that allows a more knowledgeable user to further
explore the medical reports. It has negation detection that allows our search tool to produce more
accurate results.
Principal Investigator’s name: Yang Shi, PhD and Co-PI: Dr. Jun Zhang, PhD, Dept. of EECS,
University of Wisconsin-Milwaukee
Grants/Contracts – Funded
1. The Predictive Value of Her2/neu in Patients with DCIS and Other High Risk Breast Lesions:
A Case-Control Study
PI: Judy Tjoe, MD; Co-I Sanjay Kansra, PhD
Genentech Inc.
$48,681, Supplemental award
2. REDS III: Recipient Epidemiology and Donor Evaluation Study III
PI: Alan Mast, MD, PhD, Blood Center of Wisconsin; Aurora PI: Michael Michalkiewicz, PhD
National Institutes of Health – National Heart, Lung and Blood Institute
$184,874, Phase I subaward to Aurora
3. Predictive Optimal Anticlotting Treatment for Segmented Patient Populations
PI: Peter Tonellato, PhD, Harvard Medical School; Aurora PI: Michael Michalkiewicz, PhD
National Institutes of Health – National Library of Medicine, 09/2013 – 08/2017
$180,000* subaward to Aurora (* final amount in negotiation)
4.
Tetrahydrobiopterin in Neonatal Hyperoxic Lung Injury
PI: Ru-Jeng Teng, PhD, Medical College of Wisconsin; Co-I: Scarlet Shi, PhD
CTSI Pilot and Collaborative Clinical and Translational Research Grants
$2,297 subaward to Aurora (Total CTSI award amount: $50,000)
5. Role of biomarkers and imaging in identification of early cardiotoxicity of Trastuzumab
and/or doxorubicin in breast cancer patients
PI: Rubina Qamar, MD; Co-I: Yang Shi, PhD
Aurora Cancer Care Research Award
Total Direct Funds: $25,000/1 year
Peer-Reviewed Journal Articles
1. Mirza M, Shen WK, Sofi A, Tran C, Jahangir A, Sultan S, Khan U, Viqar M, Cho C. Frequent
periodic leg movement during sleep is an unrecognized risk factor for progression of atrial
fibrillation. PLoS one 2013 (in press).
2. Krum D, Hare J, Gilbert C, Choudhuri I, Mori N, Sra J. (2013) Left Atrial Anatomy in Patients
Undergoing Ablation for Atrial Fibrillation. Journal for Atrial Fibrillation. Mar-April:5(6):36-43.
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3. Dumont N, Liu B, DeFilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B,
Tlsty TD. (2013) Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis
through Alteration of Extracellular Matrix Characteristics. Neoplasia. Mar;15(3):249-62.
4. Parhizi S, Steege LM, Pasupathy K, (2013) Mining the Relationships between Psychosocial
Factors and Fatigue Dimensions among Registered Nurses. International Journal of Industrial
Ergonomics. 43(1): 82-90.
5. Lin RC, Sir M, Sisikoglu E, Pasupathy K and Steege L (2013) Optimal Nurse Scheduling Based on
Quantitative Models of Work-related Fatigue, IIE Transactions on Healthcare Systems Engineering,
3:1, 23-38.
6. Leucker TM, Ge ZD, Procknow J, Liu Y, Shi Y, Bienengraeber M, Warltier DC, Kersten JR.
Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to
ischemia/reperfusion injury. PloS one. 2013;8:e70088.
7. Teng RJ, Du J, Afolayan AJ, Eis A, Shi Y, Konduri GG. Amp kinase activation improves
angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension. American
journal of physiology. Lung cellular and molecular physiology. 2013;304:L29-42.
8. Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D,
Oldham KT, Hillery CA, Pritchard KA, Jr. N-acetyl lysyltyrosylcysteine amide inhibits
myeloperoxidase, a novel peptide based inhibitor. J. Lipid Res. 2013.
9. Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA,
Pritchard KA, Jr. Inhibition of myeloperoxidase decreases vascular oxidative stress and increases
vasodilation in sickle cell disease mice. J. Lipid Res. 2013.
10. Du J, Li Z, Li Q, Guan T, I Yang Q, Xu H, Pritchard KA, Jr., Camara A. KS, *Shi Y. Enoyl CoA
Hydratase Domain-Containing 2, a Potential Novel Regulator of Myocardial Ischemia Injury.
Accepted for publication in Journal of American Heart Association. 2013. *corresponding author.
Book
1.
Krum D, Sra J. (2013) CT Imaging of the Left Atrium. In: Sra J, Akhtar M, Natale A, Wilber D (eds).
Practical Electrophysiology. Minneapolis: Cardiotext Publishing. (In press.)
Peer-Reviewed Conference Proceeding
1.
Agarwal A, Nfor T, Ortiz D, Tyszkowska A, Lazarov L, Cho C, Palakuru S, Jahangir A, Bajwa T,
Allaqaband S. (2013) Age-Related Differences in Survival and Predictors of Survival for Patients
Undergoing Hypothermia after Cardiac Arrest. Catheter Cardiovasc Interv 2013 (peer-reviewed
abstract). (In press.)
National and Regional Meeting Poster/Presentations
1.
Chi Cho, MS, Donald Hedeker, PhD. Modeling Multiple Wave Ecological Momentary Assessment
(EMA) data with a Mixed-Effects Location Scale Model. To be presented at 10th International
Conference for Health Policy Statistics, Chicago, IL, October 9-11, 2013 (Abstract accepted for
Presentation)
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2.
Grayburn R, Anigbogu M, Godden J, Cho C, Zwicke D, Cheema O, Hastings TE, Sulemanjee N.
Cytomegalovirus infection prophylaxis using lower dose valganciclovir in cardiac transplant
patients: a retrospective analysis of efficacy and safety. J Card Fail 2013 (in press).
3.
Mirza M, Yeneneh B, Strunets A, Cho C, Choudhuri I, Mortada ME, Nangia V, Bhatia A, Niazi I,
Sra J, Jahangir A. Obesity is associated with lower mortality in patients with implantable
cardioverter-defibrillator. Circulation 2013 (in press).
4.
Kourosh Ravvaz, Peter J Tonellato, Michael Michalkiewicz, Secondary Use of Statewide
Electronic Health Record System for Patient-Centered Outcome Research: An Application to
Anticoagulation Agents. To be presented at the The American Medical Informatics Association
(AMIA), 2013 Annual Symposium, November 16, 2013, Washington, DC, (selected for oral
presentation).
5. Kourosh Ravvaz, Michael Michalkiewicz, Peter J. Tonellato. The Development of An EMR-based
Database for Anticoagulation/Anticlotting Outcome Research. 141st APHA Annual Meeting,
Boston, MA, November 2-6, 2013 (Selected for oral presentation)
6.
Judy A. Tjoe, MD, James Marx, PhD, Maharaj Singh, PhD, Brittany Tybinko, Gary Nietzel, MD.
Breast Atypia: Questioning the Reliability of Diagnosis When Considering Therapeutic Intervention
for Risk Reduction. To be presented at 14th Annual Meeting of American Society of Breast
Surgeons, Chicago, Illinois, May 1-5, 2013.
7.
John Lung, MD Anna Karst, Ariba Khan, MD, Michael Malone, MD, Maharaj Singh, PhD. An
Electronic Medical Record Marker for Delirium in Hospitalized Elderly. To be presented at Annual
Scientific Meeting of the American Geriatrics Society, Grapevine, Texas, May 3-5, 2013.
8.
Laila Hasan, Anna Karst, Ariba Khan, MD, John Lung, MD, Michael Malone, MD, Maharaj Singh,
PhD. The Unique Needs of Older Patients Who Are Readmitted to the Hospital. To be presented
at Annual Scientific Meeting of the American Geriatrics Society, Grapevine, Texas, May 3-5, 2013.
9.
Vani, Ray, MD, Joy Mead-Meucci, MS, CSAC & Maharaj Singh, Ph.D. (2013). A decade of early
intervention for psychiatric patients in hospital emergency rooms by a Behavioral Health Intake
Team. Accepted to be presented at Academy of Psychosomatic Medicine Annual Meeting,
November 13-16, 2013. (Accepted for presentation)
10. Danish Siddiqui, MD; Kiley Bernhard, MPH; Maharaj Singh, PhD; Jon I. Einarsson, MD, MPH;
Suneet P. Chauhan, MD. (2013). Robotic Surgery: A Survey of the Utility, Impact, Current & Future
Usage . Paper accepted for oral presentation at 42nd AAGL Global Congress on Minimally
Invasive Gynecology to be held from November 10-14, 2013 at Washington, D.C.(Accepted for
presentation)
Educational/Local Presentations
Aurora Scientific Day – May 22, 2013
Abstracts presented:
1. Chris Cho, MS, Jo Ann Simmons, RN, Jennifer Farrell, RN, Mark W. Mewissen, MD. Adherence to
Standard of Care for Patients Who Underwent Endovascular AAA Repair Procedure
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2. Mahek Mirza, MD, Yeneneh Beeletsega, Anton Strunets, MD, Chris Cho, MS, Indrajit Choudhuri,
MD, Nangia Vikram, MD, Atul Bhatia, MD, Niazi Imran, MD, Jasbir Sra, MD, Arshad Jahangir, MD.
Presence of Obesity is Associated with Lower Mortality in Patients with Implantable Cardioverter
Defibrillator.
3. Anushree Agarwal, MD, Tonga Nfo, MD, Daniel Ortiz, MD, Anna Tyszkowska, MD, Ludmil Lazarov,
MD, Chris Cho, MS, Surya Palakuru, MD, Arshad Jahangir, MD, Suhai Allaqaband, MD. GenderRelated Differences in Survival and Predictors of Survival for Patients Undergoing Hypothermia
after Cardiac Arrest.
4. Larisa Emelyanova, PhD, Zain Ashary, BS, Mahek Mirza, MD, Chris Cho, MS, Farhan Rizvi, PhD,
Ross Gracious, PhD, Ekhson Holmuhamedov, PhD, Arshad Jahangir, MD. Persistent but Not
Paroxysmal Atrial Fibrillation is Associated with a Reduction in Mitochondrial Electron Transport
Chain Complexes I and II Activities in Human Atria.
5. Ahmed Dalmar, MD, Thomas Chua, MD, Maharaj Singh, PhD, Christopher Stoming. Weight Loss
after Laparoscopic Adjustable Gastric Banding: The Role of Race, BMI and Age.
6. Vani Nilakantan PhD, Brittany Tybinko, BA, Maharaj Singh PhD, Ahmed Dalmar MD and Scarlet
Shi PhD. Racial Disparities in Graft Loss Following Kidney Transplantation - A Single Center
Experience.
7. Maharaj Singh, PhD, Laura Kohler, PT, Joseph. F. Davies, MD. The Effect of Using Guided Mental
Imagery for Patients Receiving Knee or Hip Replacement.
8. Judy Tjoe, MD, Maharaj Singh, PhD, Brittany Tybinko, Gary Nietzel, MD. Breast Atypia: Timing of
Progression to Subsequent Clinically Significant Evidence.
9. John Lung, MD, Ariba Khan, MD, K. Singh, MD, Maharaj Singh, PhD, Michael Malone, MD. An
Electronic Medical Record Marker for Delirium in Hospitalized Elderly.
Other
1. Samer Shuaib, MD, Shrinivas Murthy, MD, Hani Hashim, MD, Suhail Allaqaband, MD, Chris Cho,
MS. Triglycerides and Risk Factors for Heart Disease: Their Relationship with Coronary Artery
Saphenous Vein Bypass Graft Occlusion.
2. Michael Michalkiewicz, PhD. Aurora’s Large Electronic Medical Records (EMR) as a Tool for
Patient-Centered Research and Clinical Decision Support (CDS). Opportunities and Challenges.
UWM, School of Health Sciences, Oral presentation, April 04, 2013
Editorial Board
Vani Nilakantan, PhD
BioMed Research International
Reviews for Scientific Journals
Michael Michalkiewicz, PhD
Journal of Hypertension – 2 reviews
Journal of Hypertension – 3 reviews
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Vani Nilakantan, PhD
Prostaglandins and Other Lipid Mediators
Kalyan Pasupathy, PhD
Journal for Healthcare Quality
American Journal for Health System Pharmacy
Institute of Electrical and Electronics Engineers – Transactions on Engineering Management
Scarlet Shi, PhD
Circulation
Autophagy
Hypertension
Reviews of Abstracts
Michael Michalkiewicz, PhD
Aurora Scientific Day Abstracts – 24 abstracts
Vani Nilakantan, PhD
Aurora UW Medical Group Research Committee – 4 abstracts/publications
Scarlet Shi, PhD
Aurora Scientific Day Abstracts – 64 abstracts
Reviews of Grant/Contract Applications
National
Kalyan Pasupathy, PhD
Patient-Centered Outcomes Research Institute (PCORI) – 9 reviews
Scarlet Shi, PhD
American Heart Association - 9 reviews
Intramural
Michael Michalkiewicz, PhD
Aurora IIR Patient-Centered Research – 3 proposals
Aurora Cancer Care Research Award – 4 proposals
Kalyan Pasupathy, PhD
IIR Patient-Centered Outcomes Projects – 3 proposals
Aurora Cardiovascular Surgery Research Award – 6 proposals
Aurora Cancer Care Research Award (Vince Lombardi Cancer Foundation) – 3 proposals
Scarlet Shi, PhD
Aurora Cardiovascular Surgery Research Award – 6 proposals
IIR Patient-Centered Outcomes Projects – 4 proposals
Aurora Cardiac Research Award – 1 proposal
Aurora Cardiovascular Surgery Research Award – 11 LOI
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Aurora Institutional Service
Ahmed Dalmar, MD
Member, IIR Regulatory Committee
Sanjay Kansra PhD
Member, Aurora Research Biological Safety Committee
Michael Michalkiewicz, PhD
Member, Aurora Institutional Review Board
Scientific Advisor, Aurora Biorepository – ORBIT
Biorepository Advisory Steering Committee
Member, Aurora Research Biological Safety Committee
Aurora Scientific Day, Presentations Judge
Vani Nilakantan, PhD
Co-Chair, IIR-Regulatory Committee
Biorepository Advisory Steering Committee
Member, Aurora Research Biological Safety Committee
Kalyan Pasupathy, PhD
Cardiovascular Information System Committee Member
Scarlet Shi, PhD
Member, IIR Regulatory Committee
Aurora Cardio-oncology Program, Advisory Board
Maharaj Singh, PhD
Member, Aurora Institutional Review Board
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