NAME
D. Ryan Ormond, M.D.
Department of Neurosurgery
University of Colorado School of Medicine
12631 E. 17th Avenue, Mail Stop C307
Academic Office 1, Room 5001
Aurora, CO 80045
Tel: 303.724.2305
Fax: 303.724.2300
Email: david.ormond@ucdenver.edu
POSITION TITLE
Assistant Professor,
Co-Director, Brain Tumor Program
Director, Regenerative Neurobiology Laboratory
EDUCATION/TRAINING
INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY
University of Arkansas, Fayetteville, AR
University of Washington, Seattle, WA
New York Medical College, Valhalla, NY
B.S.
M.D.
N/A
8/1996-5/2001
8/2002-6/2006
6/200562006
Honors Microbiology,
German minor
Medicine
Neurological Surgery
New York Medical College, Valhalla, NY
Emory University, Atlanta, GA
Rheinische Friedrich Wilhelms Universität, Bonn,
Germany
N/A
N/A
N/A
7/2011-6/2012 Spine Fellowship
7/2012-6/2013
Neurosurgical Oncology
Fellowship
7/2013-6/2014
AANS William P. Van
Wagenen Fellowship
A.
Positions and Honors.
Positions and Employment
2002 Boise State University, Boise, ID, Graduate Assistant, human anatomy and physiology lab
2006-2007 Westchester Medical Center, Valhalla, NY, Intern, General Surgery
2008-2009 St. Vincent’s Hospital – Manhattan, New York, NY, Chief Resident, Neurosurgery
2006-2012 New York Medical College, New York and Valhalla, NY, Resident, Neurosurgery
2010-2011 Westchester Medical Center, Valhalla, NY, Chief Resident, Neurosurgery
2011-2012 Westchester Medical Center, Valhalla, NY, Neurosurgery Spine Fellowship
2011-2012 New York Medical College, Valhalla, NY, Clinical Instructor
2012-2013 Emory University, Atlanta, GA, Neurosurgical Oncology Fellowship, Senior Associate
2013-2014 2013 AANS William P. Van Wagenen Fellowship at the Institute for Reconstructive Neurobiology,
Rheinische Friedrich Wilhelms Universität Bonn
2012-2014 Lincoln Medical and Mental Health Center, New York, NY, Attending Neurosurgeon
2014-Present Assistant Professor, University of Colorado School of Medicine
Honors and Awards
1991 Eagle Scout, Boy Scouts of America
1993 NASA SSIP Regional Winner
1995 Fleet Reserve Association, National Award
1995 National Merit Scholar
1996 Valedictorian, Centennial High School, Meridian, Idaho
1996 State of Idaho Scholarship
1996 Mu Alpha Theta Honor Society, member
1996 National Honor Society, member
1996-2001 Sturgis Fellowship, Fulbright College, University of Arkansas
2000 Golden Key National Honor Society, member
2000 Alpha Epsilon Delta Honor Society, member
2000 Delta Phi Alpha Honor Society, member
2000
The National Dean’s List
2001 Phi Beta Kappa Honor Society, member
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Curriculum Vitae: Ormond, David Ryan
2001 Senior Scholar, University of Arkansas
2001 University of Arkansas, B.S., Summa Cum Laude , Honors Microbiology, German minor
2002, 2004 Mary E. Wright Cartier Memorial Fund in Medicine Award
2002, 2003 Eikelberner Endowed Scholarship
2003 John and Mary Wilson Scholarship
2003-2006 Idaho Medical Association Scholarship
2010 New York State Neurosurgical Society Annual Meeting Resident Research Award
2010
Society for Neuroscience Annual Meeting Abstract “Hot Topics” Award
2011
Marquis Who’s Who in America
2011 Anna Samartzis Research Award
2011 New York Society for Neurosurgery Resident Research Night Second Prize
Grants
DOD Breast Cancer Research Program Breakthrough award Level 1 BC141980 (Cittelly, PI)
Title: Role of IL13RA2 as a functional biomarker in breast cancer brain metastasis.
Principal Investigator: Cittelly
Role: Co-I (1% effort)
Total Project Period: 09/30/2015 -09/30/2018
Amount of annual support: $350,000 TDC
Specific aim: To decipher the role of Il13RA2 in brain metastatic breast cancer and validate the use of novel brain metastases PDXs for functional studies in brain metastases.
Deutscher Akademischer Austausch Dienst (German Academic Exchange Service) Research Grant
Title: Cell reprogramming: direct neuronal reprogramming of mesenchymal stem cells
Principal Investigator: D. Ryan Ormond
Mentor: Oliver Brüstle
Total Project Period: 10/1/2013-6/30/2014
Amount of annual support: 10,000 €
Specific aims: 1. Develop methods to convert mesenchymal stem cells to neurons in vitro and in vivo. 2. Develop an autologous animal model of neuronal transplant after acute neurologic injury.
American Association of Neurological Surgeons, 2013 William P. Van Wagenen Fellowship
Title: Cell reprogramming: stem cell-based systems for studying nervous system diseases and repair
Principal Investigator: D. Ryan Ormond
Sponsor: Oliver Brüstle
Total Project Period: 7/1/13-6/30/14
Amount of annual support: $146,000
Specific Aims: 1. Transdifferentiate mesenchymal stem cells into functional neurons . 2. Study mechanisms of paracrine effects of neural stem cells.
American Association of Neurological Surgeons, Neurosurgery Research and Education Foundation;
NREF/Medtronic Research Fellowship
Title: Enhanced Recovery After Spinal Cord Injury Utilizing Engineered Stem Cells and Naturally-Occurring Anti
Inflammatory Compounds
Principal Investigator: D. Ryan Ormond
Sponsor: Meena Jhanwar-Uniyal
Total Project Period: 7/1/10-6/30/11
Amount of annual support: $40,000
Specific Aims: 1. To establish that stem cell therapy in conjunction with anti-inflammatory compounds will result in improved recovery from SCI. 2. To determine the molecular markers associated with SCI recovery.
University of Washington School of Medicine, Medical Student Research Training Program
Title: Purification and Properties of PIN, a Putative Protein Target of Organic Solvents in Neurotoxicity
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Curriculum Vitae: Ormond, David Ryan
Principal Investigator: D. Ryan Ormond
Sponsor: Martin Pall
Total Project Period: 6/1/03-7/31/03
Amount of annual support: $3200
Specific Aims: 1. Producing chemically pure PIN protein via recombinant DNA techniques, followed by affinity chromatography purification, 2. Testing potential methods to quantify binding affinities of PIN to a fluorescently labeled 13-residue peptide of nNOS.
Other Experience and Professional Membership
2000 Cambridge University, Cambridge, England; International Science Summer School
2002-2010 Idaho Medical Association; student representative to the Board of Trustees, Medical Education
Affairs Committee member, resident member
2006-2012 Committee of Interns and Residents; neurosurgery department representative, hospital delegate
2006-2012 New York State Neurosurgical Society, member
2006-2012 New York Society for Neurosurgery, member
2006-2012 Medical Society of the State of New York, member
2009-2012 American Association for Cancer Research, member
2009-Present Society for Neuroscience, member
2013-Present American Heart Association, member
2002-Present American Medical Association, member, student delegate, alternate delegate, chapter treasurer, chapter president
2006-Present American College of Surgeons, member
2006-Present Congress of Neurological Surgeons, member
2007-Present American Association of Neurological Surgeons, member
2012-Present Georgia Neurosurgical Society, member
2013-Present German Stem Cell Network, member
2012-Present Reviewer for Neurosurgery, Journal of Neuro-Oncology, Acta Neuropathologica Communications
2015-Present Member, AANS/CNS Joint Guidelines Committee
B.
Publications/Posters/Abstracts/Invited Lectures.
Peer-Reviewed Publications
1.
Ormond DR, LaBagnara M, Wainwright J, Neil J, Gillick J, Hillard VH, Das K. Stand-alone anchored cage versus allograft with plating for multilevel anterior cervical discectomy and fusion. Journal of Spine Disorders &
Techniques.
In revision.
2.
Amini A, Altoos B, Karam SD, Waxweiler TV, Rusthoven CG, Gaspar LE, Honce J, Damek DM, Ney DE,
Ormond DR, Lillehei KO, Chen C, Kavanagh B, Liu AK. Outcomes of Symptomatic Compared to
Asymptomatic Recurrences in Patients with Glioblastoma Multiforme (GBM). American Journal of Clinical
Oncology . In press.
3.
Delev D, Send K, Malter MP, Ormond DR, von Lehe M, Schramm J, Grote A. Subdural interhemispheric electrodes (IHE) in the presurgical evaluation of epilepsy patients. World Neurosurgery.
2015 July 22 [Epub ahead of print].
4.
Downes AE, Freeman J, Ormond DR, Lillehei K, Youssef AS. Unilateral Tailored Fronto-Orbital Approach: A
Keyhole Concept for Giant Olfactory Groove Meningiomas Technical Nuances. World Neurosurgery . 2015 May
15. [Epub ahead of print].
5.
Grote A, Witt JA, Surges R, von Lehe M, Pieper M, Christian E, Helmstaedter C, Ormond DR, Schramm J, Delev
D. A second chance: Reoperation in patients with failed surgery for intractable epilepsy – long-term outcome,
3

Curriculum Vitae: Ormond, David Ryan neuropsychology and complications. Journal of Neurology, Neurosurgery and Psychiatry . 2015 Apr 8. pii: jnnp-
2015-310322.
6.
Schowinsky J, Ormond DR, Kleinschmidt-DeMasters BK. Tibial adamantinoma: late metastasis to the brain.
Journal of Neuropathology & Experimental Neurology.
2015 Jan;74(1):95-7.
7.
Jeevan DS, Ormond DR, Kim AH, Meiteles LZ, Stidham KR, Linstrom C, Murali R. Cerebrospinal fluid leaks and encephaloceles of temporal bone origin: nuances to diagnosis and management. World Neurosurgery.
2015
Apr;83(4):560-6.
8.
Delev D, Send K, Wagner J, von Lehe M, Ormond DR, Schramm J, Grote A. Epilepsy surgery of the rolandic and immediate perirolandic cortex: surgical outcome and prognostic factors. Epilepsia.
2014;55(10):1585-93.
9.
Olson J, Nayak L, Ormond DR, Wen PY, Kalkanis SN, Ryken TC. The Role of Targeted Therapies in the
Management of Progressive Glioblastoma. Journal of Neuro-oncology . 2014 Jul;118(3):557-99.
10.
Olson J, Nayak L, Ormond DR, Wen PY, Kalkanis SN. The Role of Cytotoxic Chemotherapy in the Management of Progressive Glioblastoma. Journal of Neuro-oncology . 2014 Jul;118(3):501-55.
11.
Ormond Dr, Hadjipanayis CG. The history of neurosurgery and its relation to the development and refinement of the frontotemporal craniotomy. Neurosurgical Focus.
2014;36:4:E12.
12.
Ormond DR, Shannon C, Oppenheim J, Das K, Zeman R, Murali R, and Jhanwar-Uniyal M. Stem cell therapy in conjunction with curcumin synergistically enhances recovery from spinal cord injury. PLoS ONE . 2014; 9(2): e88916. doi:10.1371/journal.pone.0088916.
13.
Ormond DR, Hadjipanayis CG. The supraorbital keyhole craniotomy through an eyebrow incision: its origins and evolution. Minimally Invasive Surgery . 2013;2013:296469.
14.
Nduom EK, Sribnick EA, Ormond DR, Hadjipanayis CG. Neuroendoscopic resection of intraventricular tumors and cysts through a working channel with a variable aspiration tissue resector: a feasibility and safety study.
Minimally Invasive Surgery . 2013;2013:471805.
15.
Ormond DR, Dressler A, Kim S, Ronecker J, Murali R. Lumbar drains may reduce the need for permanent CSF diversion in spontaneous subarachnoid hemorrhage. British Journal of Neurosurgery.
27(2):171-4, 2013.
16.
Ormond DR, Albert L, Das K. Polyetheretherketone (PEEK) Rods in Lumbar Spine Degenerative Disease: A
Case Series. Journal of Spine Disorders & Techniques.
2012 Oct. 16. [Epub ahead of print]
17.
Ormond DR, Moscatello AL, Murali R. MRI findings of causalgia of the lower extremity following transsphenoidal resection of pituitary tumor. Case Reports in Neurological Medicine.
2012;2012:598048. Epub
2012 Sep 13.
18.
Mohan AL, Friedman MD, Ormond DR, Tobias M, Murali R, Jhanwar-Uniyal M. PI3K/mTOR Signaling
Pathways as Therapeutic Targets in Medulloblastoma. Anticancer Research . 32(8):3141-6, 2012
19.
Ormond DR, Peng H, Zeman R, Das K, Murali R, Jhanwar-Uniyal M. Recovery from spinal cord injury using naturally occurring antiinflammatory compound curcumin. Journal of Neurosurgery: Spine.
16(5):497-503,
2012.
20.
Ormond DR, Omeis I, and Abrahams JA. Uncommon presentation of an intradiploic orbital epidermoid tumor: case report. Oral Maxillofac Surg.
15(3):165-7, 2011
21.
Ormond DR, Omeis I, Mohan A, Murali R, and Narayan P. Obstructive hydrocephalus due to a third ventricular
4

Curriculum Vitae: Ormond, David Ryan neuroepithelial cyst. Case report. Journal of Neurosurgery: Pediatrics . 1:481-484, 2008.
22.
Ormond DR and Kral TA. Washing methanogenic cells with the liquid fraction from a Mars soil simulant and water mixture. J Microbiol Methods.
67(3):603-5, 2006.
Non-peer Reviewed Publications/Book Chapters
1.
Ormond DR, Bouras A, Moore M, Gary M, Province P, Prabhu R, Egan KM, Rangaraju S, Appin C,
Hadjipanayis C, Nabors B, Voloschin A, Olson JJ. Central Nervous System and Peripheral Nerves. Gansler T
(ed). American Cancer Society Textbook of Cancer . Wiley Blackwell. Oxford. 2013.
2.
Murali R, Linstrom C, Jeevan D, and Ormond DR. Infections of the Temporal Bone with Special Emphasis on the
Management of Temporal Encephaloceles: Part I. Contemporary Neurosurgery . 31(22):1-6, 2009.
3.
Murali R, Linstrom C, Jeevan D, and Ormond DR. Infections of the Temporal Bone with Special Emphasis on the
Management of Temporal Encephaloceles: Part II. Contemporary Neurosurgery . 31(23):1-6, 2009.
4.
Life on Mars—What Might it Look Like? Ormond DR. Undergraduate Honors Thesis, University of Arkansas,
Fulbright College of Arts and Sciences Honors Program. Mentor/P.I.: TA Kral. 2001.
Posters/Abstracts
1.
Cittelly DM, Hanna C, Jacobsen BM, Sartorius CA, Kabos P, Lillehei K, Ormond DR, Graner M, Borges V.
Development of novel breast cancer brain-metastases-derived xenografts and cell lines. American Association for
Cancer Research: Advances in Breast Cancer Research Meeting.
October 2015.
2.
Amini A, Altoos B, Karam SD, Waxweiler TV, Rusthoven CG, Gaspar LE, Honce J, Damek DM, Ney DE,
Ormond DR, Lillehei KO, Chen C, Kavanagh B, Liu AK. Outcomes of Symptomatic Compared to
Asymptomatic Recurrences in patients with Glioblastoma Multiforme (GBM). American Society of Therapeutic
Radiation Oncology Annual Meeting. October 2015. International Journal of Radiation Oncology* Biology*
Physics 2015;93(3):E117.
3.
Ormond DR, Wise S, Oyesiku N, Patel A, Hadjipanayis C. Endoscopic endonasal resection of clival chordomas: a case series. North American Skull Base Society Annual Meeting . February 2013. Poster Presentation. Journal of Neurological Surgery Part B: Skull Base 2013;74(S 01).
4.
Ormond DR, Kim S, Dressler A, Murali R. Lumbar drains reduce the need for permanent CSF diversion in spontaneous subarachnoid hemorrhage. American Association of Neurological Surgeons Annual Meeting . April
2012. Poster Presentation.
5.
Ormond DR, Shannon C, Das K, Zeman R, Murali R, Jhanwar-Uniyal M. Stem cell therapy and curcumin enhance recovery from moderate or severe spinal cord injury. Society for Neuroscience Annual Meeting .
November 2011. Poster Presentation.
6.
Albert L, Ormond DR, Das K. Polyetheretherketone (PEEK) vs. Titanium Rods in Lumbar Spine Degenerative
Disease: Retrospective Comparison of Two Cohorts. European Association of Neurosurgical Societies, 14 th
European Congress of Neurosurgery, Oct. 2011. Poster Presentation.
7.
LaBagnara M , Decker M, Moore B, Neil, J, Jeevan D, Ormond D R, Abrahams JM, Murali R , Marini C, Stiefel
MF. Utility of Platelet Sensitivity Assays in Traumatic Brain Injury. Congress of Neurological Surgeons Annual
Meeting , Oct. 2011. Poster Presentation.
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Curriculum Vitae: Ormond, David Ryan
8.
Ormond DR, Shannon C, Das K, Zeman R, Murali R, Jhanwar-Uniyal M. Recovery from spinal cord injury using stem cell therapy in conjunction with curcumin. American Association of Neurological Surgeons Annual
Meeting . April 2011. Electronic Poster.
9.
Jeevan D, Ormond DR, Linstrom C, Murali R. Temporal bone encephalocele: Surgical treatment by a combined tympanomastoid-middle fossa repair. American Association of Neurological Surgeons Annual Meeting . April
2011. Electronic Poster.
10.
Albert L, Ormond DR, Das K. Polyetheretherketone (PEEK) vs. Titanium Rods in Lumbar Spine Degenerative
Disease: Retrospective Comparison of Two Cohorts. American Association of Neurological Surgeons Annual
Meeting . April 2011. Electronic Poster.
11.
Ormond DR, Das K, Zeman R, Murali R, and Jhanwar-Uniyal M. Stem cell therapy in conjunction with curcumin synergistically enhances recovery from spinal cord injury. Society for Neuroscience Annual Meeting ,
2010. Poster Presentation.
12.
Ormond DR, McKenna E, Karsy M, Braun A, Murali R, and Jhanwar-Uniyal M. STAT3 promotes metastasis to the brain: demonstrated by protein, gene, and functional analysis. Abstract. American Association for Cancer
Research Annual Meeting, 2010 . Poster presentation.
13.
Karsy M, Ormond DR, Braun A, Murali R, and Jhanwar-Uniyal M. Cancer stem cells of glioblastoma multiforme: regulation by the mTOR pathway. Abstract. American Association for Cancer Research Annual
Meeting, 2010 . Poster presentation. Cancer Research 70(8 Supplement):5153-5153.
14.
Ormond DR, Das K, Zeman R, Murali R, and Jhanwar-Uniyal M. Enhanced Recovery After Spinal Cord Injury
Utilizing Engineered Stem Cells and Naturally-Occurring Anti-Inflammatory Compounds. Abstract and Eposter.
American Association of Neurological Surgeons Annual Meeting , May 2010, Philadelphia, PA.
15.
Albert A, Karsy M, Ormond DR, Braun A, Murali R, and Jhanwar-Uniyal M. Cancer stem cells in glioblastoma multiforme: Identification of signaling pathways. 8 th AACR/JCA Joint Conference – Cancer Genomics,
Epigenomics, and the Development of Novel Therapeutics.
Poster presentation. Feb. 2010.
16.
Ormond DR, Karsy M, Alba D, Mohan A, Braun A, Murali R, and Jhanwar-Uniyal M. Tumor Suppressor p53
Modulates Tumor Metastases to the Brain: Signaling Pathways Associated with MAPK, NF-kB and STAT3 in
Regulation of Cancer Stem Cells. Digital Poster, Congress of Neurological Surgeons Annual Meeting . Oct.
2009, New Orleans, LA.
17.
Karsy M, Albert L, Geis M, Ormond DR, Braun A, Murali R, and Jhanwar-Uniyal M. Neural Stem Cells in
Glioblatoma multiforme: Signalling pathways associated with growth and differentiation. Abstract and Poster.
American Association for Cancer Research Annual Meeting , 2009.
18.
Ormond DR, Omeis I, Casey L, D’Aquila K, Yelon J, and Abrahams JA. Evaluating Compliance with Traumatic
Brain Injury Guidelines with Standard Outcomes Software: A Comparison of Effectiveness. Digital Poster,
Congress of Neurological Surgeons Annual Meeting.
Sept. 2008, Orlando, FL.
19.
Ormond DR and Pall ML. Purification and Properties of PIN, a Putative Protein Target of Organic Solvents in
Neurotoxicity. Abstract. Journal of Investigative Medicine.
52(1):53, 2004.
20.
Ormond DR, Bekkum CR, and Kral TA. Growth of Methanogens on a Mars Soil Simulant using the Liquid
Fraction from a Mars Soil Simulant/Water Mix as Buffer. Poster. Meteorological Society Annual Meeting .
Rome, Italy. September 2001.
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Curriculum Vitae: Ormond, David Ryan
21.
Ormond DR, Bekkum CR, and Kral TA. Growth of Methanogens on a Mars Soil Simulant using the Liquid
Fraction from a Mars Soil Simulant/Water Mix as Buffer. Poster. American Society for Microbiology Annual
Meeting. Poster Presentation . Orlando, Florida, May 2001.
Presentations/Invited Lectures
1.
Ormond DR. Dynamic recapitulation: revising the epigenetic landscape. Invited lecture, Grand Rounds.
University of Utah School of Medicine, Department of Neurosurgery , Salt Lake City, UT, October 2, 2013.
2.
Ormond DR. Dynamic recapitulation: revising the epigenetic landscape. Invited lecture, Grand Rounds.
University of Colorado School of Medicine, Department of Neurosurgery , Denver, Colorado, June 4, 2013.
3.
Ormond DR. Dynamic recapitulation: revising the epigenetic landscape. Invited lecture, Grand Rounds. New
York Medical College, Valhalla, New York , May 31, 2013.
4.
Ormond DR, Wise S, Oyesiku N, Patel A, Hadjipanayis C. Endoscopic endonasal resection of clival chordomas: a case series. Georgia Neurosurgical Society Annual Fall Scientific Assembly . Nov. 17, 2012. Oral Presentation.
5.
Ormond DR, Murali R. “Glial Tumors of the Brain.” Combined Neurology and Neurosurgery Grand Rounds .
New York Medical College . June 6, 2012
6.
Ormond DR, Shannon C, Das K, Zeman R, Murali R, Jhanwar-Uniyal M. Recovery from SCI: utilizing antiinflammatory compounds and stem cell therapy. The Ninth Annual Louis R.M. Del Guercio, M.D., Lectureship &
Research Day, Westchester Medical Center . Abstract and presentation. May 4, 2011.
7.
Ormond DR, Jhanwar-Uniyal M. Stem Cell Therapy in Conjunction with Naturally-Occurring Anti-inflammatory
Compounds Synergistically Enhances Recovery from Spinal Cord Injury.
2011 NREF Research Symposium .
Invited Presentation. April 12, 2011.
8.
Ormond DR, Jeevan D, LaBagnara M, Murali R. Chiari Malformations and Syringohydromyelia. Combined
Neurology and Neurosurgery Grand Rounds , New York Medical College , Mar. 23, 2011.
9.
Ormond DR, Albert L. Neurosurgical Emergencies. Department of Neurology Grand Rounds, New York Medical
College , Sept. 30, 2010.
10.
Ormond DR, Das K, Zeman R, Murali R, and Jhanwar-Uniyal M. Utilizing Stem Cells and Anti-inflammatory
Compounds to Enhance Recovery from Spinal Cord Injury. New York State Neurosurgical Society, Resident
Research Meeting.
June 4, 2010. Presentation.
11.
Ormond DR, Das K, Zeman R, Murali R, and Jhanwar-Uniyal M. Utilizing Stem Cells and Anti-inflammatory
Compounds to Enhance Recovery from Spinal Cord Injury. New York Society for Neurosurgery, Resident
Research Meeting , May 27, 2010. Presentation.
12.
Ormond DR, Das K, Zeman R, Murali R, and Jhanwar-Uniyal M. Enhanced Recovery After Spinal Cord Injury
Utilizing Engineered Stem Cells and Naturally-Occurring Anti-Inflammatory Compounds. The Eighth Annual
Louis R.M. Del Guercio, M.D., Lectureship & Research Day, Westchester Medical Center . Abstract and presentation. November 2009.
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Curriculum Vitae: Ormond, David Ryan
8