RAPAMYCIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
VE6250000
Rapamycin
53123-88-9
199509
7
C51-H79-N-O13
914.31
Drug
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* Antibiotic AY 22989
* AY 22989
* NSC 226080
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18220 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB83-228577
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968Volume(issue)/page/year: 28,721,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 597 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968Volume(issue)/page/year: 31,539,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 21 mg/kg/14D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - renal function tests depressed
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
58,169,1991
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 60 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,321,1983
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,321,1983
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,321,1983
REACTIVE BLACK 5
RTECS NUMBER
CHEMICAL NAME
: QJ6402500
: 2,7-Naphthalenedisulfonic acid,
3,6-(bis(4-((2-hydroxyethyl)sulfonyl)phenyl)bis(azo))
- 5-amino-4-hydroxy-, di(hydrogen sulfate) ester,
tetrasodium salt
CAS REGISTRY NUMBER
: 17095-24-8
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
JQ
:
:
:
:
:
199812
6
C26-H25-N5-O19-S6.4Na
995.88
L66J BZ CNUNR DSW2OSWO& DSWO HSWO INUNR DSW2OSWO&
&-NA- 4
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Cavalite Black B
* Celmazol Black B
* C.I. 20505
* C.I. Reactive Black 5
* Diamira Black B
* Drimarene Black R/K 3B
* Intracron Black VS-B
* Levafix Black E-B
* Primazin Black BN
* Reactive Black 5
* Remazol Black B
* Remazol Black GF
* Sumifix Black B
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 72 gm/kg/86W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
TKORAS Trudy Kazakhskogo Nauchno-Issledovatel'skogo Instituta Onkologii i
Radiologii. Transactions of the Kazakh Scientific Research Institute of
Oncology and Radiology. (Kazakhskii Nauchno- Issledovatel'skii Institut
Onkologii i Radiologii, Alma-Ata, USSR) V.11965Volume(issue)/page/year: 3,53,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 gm/kg/71W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
TKORAS Trudy Kazakhskogo Nauchno-Issledovatel'skogo Instituta Onkologii i
Radiologii. Transactions of the Kazakh Scientific Research Institute of
Oncology and Radiology. (Kazakhskii Nauchno- Issledovatel'skii Institut
Onkologii i Radiologii, Alma-Ata, USSR) V.11965Volume(issue)/page/year: 3,53,1967
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T1620
No. of Facilities: 15 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 29 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1620
No. of Facilities: 220 (estimated)
No. of Industries: 8
No. of Occupations: 12
No. of Employees: 28998 (estimated)
No. of Female Employees: 19828 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
RESCINNAMINE
RTECS NUMBER
CHEMICAL NAME
: ZG0700000
: 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid,
18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl
ester,
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
TO1
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
3,4,5-trimethoxycinnamate (ester)
24815-24-5
0075328
4-25-00-01323 (Beilstein Handbook Reference)
199803
10
C35-H42-N2-O9
634.79
T F6 D5 C666 EM ON&&TTTJ HO1 SOV1U1R CO1 DO1 EO1&
UVO1
: Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Anaprel
* Apoterin
* Cartric
* Cinamine
* Cinnaloid
* Methyl reserpate 3,4,5-trimethoxycinnamic acid ester
* Methyl 18-O-(3,4,5-trimethoxycinnamoyl)reserpate
* Moderil
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Normorescina
Raupyrol
Raurescine
Recinnamine
Recitensina
Rescaloid
Rescamin
Rescidan
Rescinnamine
Rescinpal
Rescisan
Resepinine (C35 alkaloid)
Reserpinine
Resipal
Reskinnamin
Scinnamina
Tenamine
Trimethoxycinnamoyl methyl reserpate
Trimethoxy cinnamoyl reserpate de methyl
3,4,5-Trimethylcinnamic acid, ester with methyl reserpate
3,4,5-Trimethylcinnamoyl methyl reserpate
Tuareg
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 4 ug/kg/D
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Behavioral - antipsychotic
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,517,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,898,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,898,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,898,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E.,
and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,109,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark
Office, Foreign Patents, Washington, DC 20231) Discontinued.
Volume(issue)/page/year: #5226M
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 263 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark
Office, Foreign Patents, Washington, DC 20231) Discontinued.
Volume(issue)/page/year: #5226M
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00965
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 23,600,1973
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE
: 32 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
80,239,1982
RESERPINE
RTECS NUMBER
CHEMICAL NAME
: ZG0350000
: 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid,
18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl
ester,
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Anquil
3,4,5-trimethoxybenzoate (ester)
50-55-5
0102014
4-25-00-01319 (Beilstein Handbook Reference)
199904
82
C33-H40-N2-O9
608.75
T F6 D5 C666 EM ON&&TTTJ HO1 SOVR CO1 DO1 EO1& TO1
UVO1
: Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Natural Product
:
:
:
:
:
:
:
:
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Apoplon
Banasil
Bioserpine
Crystoserpine
Deserpine
Diutensen-R
Elserpine
ENT 50146
Escaspere
Eserpine
Eskaserp
Gilucard
Hiposerpil
Kitine
Klimanosid
Lemiserp
Loweserp
Mayserpine
Methylreserpate 3,4,5-trimethoxybenzoic acid
Naquival
NCI-C50157
Quiescin
Raucap
Raulen
Raupasil
Raupoid
Raurine
Rausan
Rau-Sed
Rausedan
Rausedil
Rausedyl
Rauserpol
Rausingle
RCRA waste number U200
Recipin
Resaltex
Resedril
Resedrex
Rese-Lar
Reser-AR
Reserbal
Resercaps
Resercen
Reserfia
Reserjen
Reserlor
Reserp
Reserpal
Reserpamed
Reserpanca
Reserpene
Reserpex
Reserpidefe
Reserpil
Reserpine
Reserpoid
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Reserpur
Resersana
Reserutin
Resiatric
Residine
Resocalm
Resomine
Resperin
Resperine
Respital
Restran
Rezerpin
Riserpa
Rivased
Rivasin
Rolserp
Salupres
Salutensin
Sandril
Sedaraupin
Sedserp
Seominal
Serfin
Serfolia
Serp-AFD
Serpaloid
Serpanray
Serpasil
Serpasil premix
Serpasol
Serpate
Serpatone
Serpazil
Serpazol
Serpedin
Serpen
Serpentina
Serpiloid
Serpine (pharmaceutical)
Serpivite
Serplex K
Serpogen
Serpoid
Serpone
Serpresan
Serpyrit
Sertabs
Sertina
Temposerpine
Triserpin
3,4,5-Trimethoxybenzoyl methyl reserpate
USAF CB-27
Vio-Serpine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 420 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
REFERENCE :
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88,
Oxford,
UK) V.11970- Volume(issue)/page/year: 11,555,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 44 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 110,20,1957
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
56,377,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E.,
and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,111,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan)
Volume(issue)/page/year: -,1453,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.91974- Volume(issue)/page/year: 10,519,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5610 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1453,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 21 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - changes in motor activity (specific assay)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 14,1040,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed.,
Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,234,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 7 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JDGRAX Journal of Drug Research. (National Organization for Drug
Research
and Control, POB 29, Cairo, Egypt)
Volume(issue)/page/year:
6(3),19,1974
V.2-
1969-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E.,
and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,111,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 137,375,1962
V.4-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 23,600,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,315,1972
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 945 mg/kg/75W-C
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
1,201,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 54 mg/kg/9W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 124,237,1960
V.4-
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 456 ug/kg/Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1Volume(issue)/page/year: 2,672,1974
1823-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 54 mg/kg/77W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see
CRASEV.
Volume(issue)/page/year: 254,1535,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 132 mg/kg/2.5Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 32(7),76,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 433 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-193,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 32(7),76,1986
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 216 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - adrenal cortex tumors
Skin and Appendages - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-193,1980
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 73 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 2,672,1974
TYPE OF TEST
ROUTE OF EXPOSURE
: TD - Toxic dose (other than lowest)
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 24 mg/kg/13Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Brain and Coverings - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK)
Volume(issue)/page/year: 2,672,1974
V.1-
1823-
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 16 mg/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 2,672,1974
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 340 mg/kg/3Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Gastrointestinal - tumors
Endocrine - thyroid tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 32(7),76,1986
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1120 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Blood - tumors
Skin and Appendages - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 32(7),76,1986
** REPRODUCTIVE DATA **
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Intravenous
Human - woman
200 ug/kg
female 39 week(s) after conception
on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn
St.,
Chicago, IL 60610) V.1-80(3), 1911-50; V.1001960Volume(issue)/page/year: 90,286,1955
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - woman
DOSE
: 4800 ug/kg
SEX/DURATION
: female 32-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
AGPSA3 AMA Archives of General Psychiatry. (Chicago, IL) V.1-2,
1959-60.
For publisher information, see ARGPAQ. Volume(issue)/page/year:
2,606,1960
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 11130 ug/kg
SEX/DURATION
: male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 200,585,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 17500 mg/kg
SEX/DURATION
: female 3-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 100,555,1959
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
6 mg/kg
female 60 day(s) pre-mating
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 156,587,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 21217 ug/kg
SEX/DURATION
: female 30 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 156,587,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
TJXMAH Tokushima Journal of Experimental Medicine. (Univ. of Tokushima,
School of Medicine, 3, Kuramoto-cho, Tokushima, Japan) V.11954Volume(issue)/page/year: 23,1,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 700 ug/kg
SEX/DURATION
: female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,
Evanston, IL 60204) V.11948- Volume(issue)/page/year: 27,318,1961
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2500 ug/kg
SEX/DURATION
: female 19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
NISFAY Nippon Sanka Fujinka Gakkai Zasshi.
Journal of the Japan Society
of
Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken
Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan)
V.11949- Volume(issue)/page/year: 30,161,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
65,563,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1250 ug/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 28,177,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 ug/kg
SEX/DURATION
: female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
EXNEAC Experimental Neurology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11959- Volume(issue)/page/year: 6,263,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3 mg/kg
SEX/DURATION
: female 12-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Effects on Newborn - physical
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 13,652,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1500 ug/kg
SEX/DURATION
: female 12-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - biochemical and metabolic
Reproductive - Effects on Newborn - physical
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.91987Volume(issue)/page/year:
11,515,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 12-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA
94022)
V.11972- Volume(issue)/page/year: 9,75,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
78,225,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4 mg/kg
SEX/DURATION
: female 16-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003)
Volume(issue)/page/year: 27,35A,1983
V.1-
1968-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 800 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 118,857,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 800 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Maternal Effects - other effects
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 118,857,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 118,857,1965
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Intramuscular
Rodent - rat
1500 ug/kg
female 10 day(s) after conception
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 118,857,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 9 mg/kg
SEX/DURATION
: female 1-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
15QWAW "Agents Affecting Fertility, a Symposium, 1964," Austin, C.R., and
J.S. Perry, eds., Boston, Little, Brown & Co., 1965
Volume(issue)/page/year:
-,290,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3750 ug/kg
SEX/DURATION
: male 15 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
REFERENCE :
ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd.
Saint-Germain,
F-25280 Paris Cedex 06, France) V.11939- Volume(issue)/page/year:
23,281,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya
Kniga,
113095 Moscow, USSR) No.11936- Volume(issue)/page/year:
43(12),10,1967
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
600 ug/kg
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 4,2937,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10 mg/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 13,345,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 120 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.11939Volume(issue)/page/year: 35,161,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 400 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave.
S,
Birmingham, AL 35282) V.11950- Volume(issue)/page/year: 12,346,1961
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3200 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave.
S,
Birmingham, AL 35282) V.11950- Volume(issue)/page/year: 12,346,1961
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1600 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 83,1405,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE
: 32 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
80,239,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Primate - monkey
DOSE
: 100 mg/kg
SEX/DURATION
: female 14 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
124,726,1956
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 170 ug/kg
SEX/DURATION
: female 35-68 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 92,711,1965
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Subcutaneous
: Rodent - guinea pig
DOSE
: 340 ug/kg
SEX/DURATION
: female 35-68 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 92,711,1965
** MUTATION DATA **
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 ug
REFERENCE :
ECEBDI Experimental Cell Biology. (S. Karger Pub., Inc., 79 Fifth Ave.,
New
York, NY 10003) V.441976- Volume(issue)/page/year: 50,271,1982
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 2200 ng/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,190,1981
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 mg/kg
REFERENCE :
BPBSDA Bulletin of the Philippine Biochemical Society.
Biochemical Soc., POB 593, Manila, Philippines) V.1Volume(issue)/page/year: 2,52,1979
(Philippine
1978-
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 30 mg/kg/48H
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 12,298,1978
TYPE OF TEST
: Dominant lethal test
No.1-
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 ug/kg
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical
Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.11967- Volume(issue)/page/year: 12(3),19,1978
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 4 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 15,11,1994
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
13,133,1989
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 4 ng/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
327,237,1995
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,211,1980
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,211,1980
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,330,1987
TOXICOLOGY REVIEW
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis).
(C.V. Mosby
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146)
Volume(issue)/page/year: 5,480,1964
V.1-
1960-
TOXICOLOGY REVIEW
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For
publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84711
No. of Facilities: 68 (estimated)
No. of Industries: 1
No. of Occupations: 6
No. of Employees: 2770 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84711
No. of Facilities: 142 (estimated)
No. of Industries: 2
No. of Occupations: 10
No. of Employees: 5611 (estimated)
No. of Female Employees: 2414 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Aspergillus-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-193,1980
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
RESORCINOL
RTECS NUMBER
: VG9625000
CHEMICAL NAME
: Resorcinol
CAS REGISTRY NUMBER
: 108-46-3
BEILSTEIN REFERENCE NO. : 0906905
REFERENCE
: 4-06-00-05658 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 58
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
C6-H6-O2
110.12
QR CQ
Tumorigen
Drug
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzene, m-dihydroxy* m-Benzenediol
* 1,3-Benzenediol
* C.I. 76505
* C.I. Developer 4
* C.I. Oxidation Base 31
* Developer O
* Developer R
* Developer RS
* m-Dihydroxybenzene
* 1,3-Dihydroxybenzene
* m-Dioxybenzene
* Durafur developer G
* Fouramine RS
* Fourrine 79
* Fourrine EW
* m-Hydroquinone
* 3-Hydroxycyclohexadien-1-one
* m-Hydroxyphenol
* 3-Hydroxyphenol
* Nako TGG
* NCI-C05970
* Pelagol Grey RS
* Pelagol RS
* Phenol, m-hydroxy* RCRA waste number U201
* Resorcin
* Resorcine
* Resorcinol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REFERENCE :
IHFCAY Industrial Hygiene Foundation of America, Chemical and
Toxicological
Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year:
6,1,1967
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,234,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 11-4/1970
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,519,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 301 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - changes in structure or function of salivary glands
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 11-4/1970
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 160 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 11-4/1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - tetany
Behavioral - coma
REFERENCE :
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La
Suisse
Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.11881Volume(issue)/page/year: 15,561,1895
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.11988Volume(issue)/page/year: 4,105,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 61,291,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 213 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZGIMAL Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete.
(Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.11946Volume(issue)/page/year: 2,333,1947
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Subcutaneous
Mammal - cat
110 mg/kg
Behavioral - convulsions or effect on seizure threshold
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 72,241,1913
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3360 mg/kg
TOXIC EFFECTS :
Skin and Appendages - primary irritation (after topical exposure)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
37,596,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - tetany
Behavioral - coma
REFERENCE :
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La
Suisse
Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.11881Volume(issue)/page/year: 15,561,1895
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 270 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
5400 mg/kg/17D-I
Endocrine - changes in thymus weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-403,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8450 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in adrenal weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-403,1992
(Research
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 504 mg/kg/28D-C
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 11-4/1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3600 mg/kg/17D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-403,1992
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 27300 mg/kg/13W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-403,1992
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Administration onto the skin
Rodent - mouse
4800 mg/kg/12W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
19,413,1959
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 20 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
90,91,1981
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
135,109,1984
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 80 mg/L
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 32,533,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 40 mg/L
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 32,533,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 mmol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
63,47,1992
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1600 mg/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland)
14,251,1981
V.1-
1975- Volume(issue)/page/year:
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 90 mg/m3 (20 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 45 mg/m3 (10 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,155,1977
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,155,1977
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
47,75,1978
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 5(3),167,1986
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 10 ppm (45 mg/m3), JAN1999
OEL-BELGIUM:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993
OEL-DENMARK: TWA 10 ppm (45 mg/m3), JAN1999
OEL-FINLAND:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993
OEL-HUNGARY:TWA 45 mg/m3;STEL 90 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 10 ppm (45 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 10 ppm (45 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (45 mg/m3);STEL 20 ppm (90 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 45 mg/m3, MAC(STEL) 90 mg/m3, JAN1999
OEL-SWEDEN: NGV 10 ppm (45 mg/m3), Skin, JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO RESORCINAL-air:10H TWA 10 ppm;STEL 20 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 67220
No. of Facilities: 4488 (estimated)
No. of Industries: 45
No. of Occupations: 42
No. of Employees: 40431 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 67220
No. of Facilities: 6842 (estimated)
No. of Industries: 30
No. of Occupations: 43
No. of Employees: 100792 (estimated)
No. of Female Employees: 56465 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (gavagae);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-403,1992
(Research
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
RESTRICTION ENDONUCLEASE BAM HI
RTECS NUMBER
: RF0757000
CHEMICAL NAME
: Nuclease, restriction endodeoxyribo-, Bamhi
CAS REGISTRY NUMBER
: 81295-09-2
LAST UPDATED
: 199509
DATA ITEMS CITED
: 3
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* BamHi
* E.C. 3.1.23.6
* Endodeoxyribonuclease Bamfi
* Endodeoxyribonuclease Bamhi
* Endodeoxyribonuclease Bamki
* Endodeoxyribonuclease Bamni
* Endodeoxyribonuclease Bsti
* Endonuclease Bamhi
* Restriction endonuclease Alii
* Restriction endonuclease Bamhi
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 2000 units/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
262,177,1991
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 25 units
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
180,109,1987
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 units
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
326,83,1995
RESTRICTION ENDONUCLEASE PVU II
RTECS NUMBER
: RF0758100
CHEMICAL NAME
: Nuclease, restriction endodeoxyribo-, Pvuii
CAS REGISTRY NUMBER
: 81295-34-3
LAST UPDATED
: 199312
DATA ITEMS CITED
: 3
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* E.C. 3.1.23.33
* Endodeoxyribonuclease Pvuii
* Restriction endonuclease Cfr6I
* Restriction endonuclease Pvuii
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 200 units
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
22,26,1993
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 30 units
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
213,233,1989
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 20 units
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
302,25,1993
RESTRICTION ENDONUCLEASE SAL I
RTECS NUMBER
: RF0758500
CHEMICAL NAME
: Nuclease, restriction endodeoxyribo-, Sali
CAS REGISTRY NUMBER
: 81295-38-7
LAST UPDATED
: 198803
DATA ITEMS CITED
: 1
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* E.C. 3.1.23.37
* Endodeoxyribonuclease Sali
* Endodeoxyribonuclease Xami
* Restriction endonuclease Hgiciii
* Restriction endonuclease Hgidii
* Restriction endonuclease Sali
* SalI
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 50 units
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
180,109,1987
RETINAL
RTECS NUMBER
: VH6407000
CHEMICAL NAME
: Retinal, all-transCAS REGISTRY NUMBER
: 116-31-4
BEILSTEIN REFERENCE NO. : 1914183
REFERENCE
: 4-07-00-01253 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C20-H28-O
MOLECULAR WEIGHT
: 284.48
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Axerophthal
* Retinal
* all-E-Retinal
* all-trans-Retinal
* E-Retinal
* trans-Retinal
* Retinaldehyde
* Retinene
* alpha-Retinene
* Retinene 1
* Vitamin A aldehyde
* trans-Vitamin A aldehyde
* Vitamin A1 aldehyde
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Mammary gland
DOSE/DURATION
: 3 umol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 70,949,1983
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland)
V.211967- Volume(issue)/page/year: 44,356,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RETINAL (CIS,9-)
RTECS NUMBER
: VH6406500
CHEMICAL NAME
: Retinal, 9-cisCAS REGISTRY NUMBER
: 514-85-2
BEILSTEIN REFERENCE NO. : 1914180
REFERENCE
: 4-07-00-01254 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C20-H28-O
MOLECULAR WEIGHT
: 284.48
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
*
9-cis-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatet
raenal
* Isoretinene A
* 9-cis-Retinal
* 9-cis-Retinaldehyde
* 9-cis-Vitamin A aldehyde
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - hamster
DOSE
: 25 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
83,563,1986
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RETINOL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
VH6750000
Retinol, all trans68-26-8
0403040
4-06-00-04133 (Beilstein Handbook Reference)
199812
61
C20-H30-O
286.50
L6UTJ A1 B1U1Y1&U2U1Y1&U2Q C1 C1
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* ACON
* Afaxin
* Agiolan
* Alphalin
* Alphasterol
* Anatola
* Anatola A
* Anti-infective vitamin
* Antixerophthalmic vitamin
* Aoral
* Apexol
* Aquasynth
* Atars
* ATAV
* Avibon
* Avita
* Avitol
* Axerophthol
* Biosterol
* Chocola A
*
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1
-ol
* Disatabs Tabs
* Dofsol
* Epiteliol
* HI-A-Vita
* Lard factor
* Myvpack
* 2,4,6,8-Nonatetraen-1-ol,
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)* Oleovitamin A
* Ophthalamin
* Prepalin
* Retinol
* all-trans-Retinol
* Retrovitamin A
* Testavol
* Vaflol
* Vafol
* VI-Alpha
* Vitamin A
* Vitamin A1
* Vitamin A alcohol
* Vitamin A1 alcohol
* all-trans-Vitamin A alcohol
* Vitavel-A
* Vitpex
* Vogan
* Vogan-neu
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 5475 ku/kg/1Y-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - pleural effusion
Gastrointestinal - other changes
Musculoskeletal - other changes
REFERENCE :
CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11962Volume(issue)/page/year: 21,435,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AVSUAR Acta Dermato-Venereologica, Supplementum. (Almqvist & Wiksell,
POB
45150, S-10430 Stockholm, Sweden) No.11929Volume(issue)/page/year:
74,29,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1510 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
51ZKAN "The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York,
Academic
Press, Inc., 1984 Volume(issue)/page/year: 2,287,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1510 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63141) 1979Volume(issue)/page/year: 6,652,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 73 mL/kg/16D-I
TOXIC EFFECTS :
Musculoskeletal - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Related to Chronic Data - death
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 87,290,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 73 mL/kg/16D-I
TOXIC EFFECTS :
Musculoskeletal - other changes
Nutritional and Gross Metabolic - changes in calcium
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 87,290,1969
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE
: 68 mg/kg
SEX/DURATION
: female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.11953Volume(issue)/page/year:
43,750,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE
: 200 mg/kg
SEX/DURATION
: female 8 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
JGHUAY Journal de Genetique Humaine. (Editions Medecine et Hygiene, Case
229, 1211 Geneva 4, Switzerland) V.11952- Volume(issue)/page/year:
23,135,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 76560 ug/kg
SEX/DURATION
: female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
3,1,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 113 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,
Evanston, IL 60204) V.11948- Volume(issue)/page/year: 13,556,1954
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
150 mg/kg
female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,
Evanston, IL 60204) V.11948- Volume(issue)/page/year: 13,556,1954
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 683 mg/kg
SEX/DURATION
: female 4-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - other measures of fertility
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,
Evanston, IL 60204) V.11948- Volume(issue)/page/year: 13,556,1954
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
alive at weaning per #
Reproductive - Effects
weight
gain)
REFERENCE :
AMPLAO AMA Archives of
For
publisher information,
TDLo - Lowest published toxic dose
Oral
Rodent - rat
22 mg/kg
female 1-22 day(s) after conception
on Newborn - weaning or lactation index (e.g., #
alive at day 4)
on Newborn - growth statistics (e.g.%, reduced
Pathology.
see APLMAS.
(Chicago, IL)
V.50(4)-69, 1950-60.
Volume(issue)/page/year: 66,278,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 240 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.11920- Volume(issue)/page/year:
57,525,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
DOSE
: 1200 ku/kg
SEX/DURATION
: female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(100),S53,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 60060 ug/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 13,25,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 60 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 30(1),13A,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 60 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
SHKKAN Shika Kiso Igakkai Zasshi. Journal of the Japanese Association
for
Basic Dentistry. (Shika Kiso Igakkai, Hanayama Bldg., 1-44-2 Komagome,
Toshima-ku, Tokyo 170, Japan) V.11959- Volume(issue)/page/year:
27,353,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 30 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 33,1,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 150 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.11919Volume(issue)/page/year: 52,300,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 72 mg/kg
SEX/DURATION
: female 11-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 15,19A,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 150 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128)
Discontinued.
Volume(issue)/page/year: 2(4),325,1983
V.1-12, 1982-1993.
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 30 mg/kg
SEX/DURATION
: female 3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
REFERENCE :
AOBIAR Archives of Oral Biology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11959Volume(issue)/page/year:
18,729,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 120 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
DKBSAS Doklady Biological Sciences (English Translation). Translation of
DANKAS: Biological Section. (Plenum Pub. Corp., 233 Spring St., New York,
NY
10013) V.1121957- Volume(issue)/page/year: 169,476,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 9610 mg/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 10,541,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
30 mg/kg
lactating female 1 day(s) post-birth
Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
REFERENCE :
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975 Volume(issue)/page/year: -,83,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 375 mg/kg
SEX/DURATION
: female 7-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
5,355,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 45045 ug/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 24(1),29A,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 145 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
10,732,1965
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - mouse
145 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
10,732,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 145 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
10,732,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 180 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
REFERENCE :
ARINAU Annual Report of the Research Institute of Environmental Medicine,
Nagoya University. (Nagoya, Japan) V.1-25, 1951-80.
Volume(issue)/page/year: 14,53,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 96 mg/kg
SEX/DURATION
: female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
PJACAW Proceedings of the Japan Academy. (Tokyo, Japan) V.21-53,
1945-77.
For publisher information, see PJABDW. Volume(issue)/page/year:
41,83,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 480 mg/kg
SEX/DURATION
: female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
PJACAW Proceedings of the Japan Academy. (Tokyo, Japan) V.21-53,
1945-77.
For publisher information, see PJABDW. Volume(issue)/page/year:
41,83,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 12 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho
University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.11954- Volume(issue)/page/year: 8,175,1961
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 480 mg/kg
SEX/DURATION
: female 10-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)
V.1-98, 1953-86. For Publisher information, see DEVPED
Volume(issue)/page/year: 12,263,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 120 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7.
Volume(issue)/page/year: 25,165,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 240 mg/kg
SEX/DURATION
: female 14-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 25,165,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 45 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 12,581,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 77 mg/kg
SEX/DURATION
: female 8-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
JIDOAA Experimental Animals. Jikken Dobutso Iho. (Nippon Jikken Dobutsu
Gakkai, c/o Keio Gijuku Daigaku Igakubu Jikken Dobutsu Senta, 35
Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.11952Volume(issue)/page/year: 35,387,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 52550 ug/kg
SEX/DURATION
: female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 24(1),12A,1981
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 17 umol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 45,630,1971
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 4 mg/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon
Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)
V.17(7)25, 1981-89. For publisher information, see EJCAEL
Volume(issue)/page/year:
21,1089,1985
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 8 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
414,157,1998
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 4 mg/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon
Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)
V.17(7)25, 1981-89. For publisher information, see EJCAEL
Volume(issue)/page/year:
21,1089,1985
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 20700 mg/kg/69W (Intermittent)
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 77,149,1986
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Mammary gland
DOSE/DURATION
: 3 umol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 70,949,1983
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland)
V.211967- Volume(issue)/page/year: 44,356,1987
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 15600 mg/kg/1Y (Intermittent)
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 77,149,1986
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland)
V.211967- Volume(issue)/page/year: 44,356,1987
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 8 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
246,67,1991
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 24 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
246,67,1991
*** REVIEWS ***
TOXICOLOGY REVIEW
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis).
(C.V. Mosby
Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146)
Volume(issue)/page/year: 5,480,1964
V.1-
1960-
TOXICOLOGY REVIEW
ARVPAX Annual Review of Pharmacology.
(Palo Alto, CA)
V.1-15, 1961-75.
For
publisher information, see ARPTDI.
Volume(issue)/page/year: 5,447,1965
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 15,121,1976
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
6,351,1979
TOXICOLOGY REIVEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB-275-754
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 6(3),279,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1676
No. of Facilities: 546 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 12809 (estimated)
No. of Female Employees: 9075 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RETINYL PALMITATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
:
:
:
:
:
:
:
VH6860000
Retinol, all-trans-, palmitate
79-81-2
37340-08-2
1917366
4-06-00-04135 (Beilstein Handbook Reference)
199701
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
38
C36-H60-O2
524.96
L6UTJ A1 B1U1Y1&U2U1Y1&U2OV15 C1 C1
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Aquasol A
* Arovit
* Optovit-A
* Retinol palmitate
* Retinyl palmitate
* Vitamin A palmitate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7910 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63141) 1979Volume(issue)/page/year: 6,652,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63141) 1979Volume(issue)/page/year: 6,652,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4760 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 25(12),84,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5250 ku/kg/21D-I
TOXIC EFFECTS :
Liver - other changes
Musculoskeletal - other changes
Related to Chronic Data - death
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,
Evanston, IL 60204) V.11948- Volume(issue)/page/year: 9,589,1952
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 13750 ug/kg
SEX/DURATION
: female 35 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Fertility - other measures of fertility
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 50,223,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 36 mg/kg
SEX/DURATION
: male 26 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60.
For
publisher information, see APLMAS. Volume(issue)/page/year: 56,333,1953
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 248 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.11909/10Volume(issue)/page/year: 144,429,1964
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
16500 ug/kg
SEX/DURATION
: female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 10,269,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 206 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 144,429,1964
V.1-
1909/10-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 275 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
JAINAA Journal of the Anatomical Society of India. (Dept. of Anatomy,
Medical College, Aurangabad 431 001, India) V.11952Volume(issue)/page/year: 23,89,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 440 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.11920- Volume(issue)/page/year:
57,525,1976
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 138 mg/kg
SEX/DURATION
: female 16 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 50,223,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 275 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.11921Volume(issue)/page/year: 41,141,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 82500 ug/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York,
NY
10003) V.11945- Volume(issue)/page/year: 109,89,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 413 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176,
Jena DDR-6900, Ger. Dem. Rep.) V.11886- Volume(issue)/page/year:
152,329,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
1350 mg/kg
female 11-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International
Inc.,
P.O. Box 426, Fayetteville, NY 13066) V.11973Volume(issue)/page/year: 38,739,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 275 mg/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)
V.1-98, 1953-86. For Publisher information, see DEVPED
Volume(issue)/page/year: 30,219,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 275 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)
V.1-98, 1953-86. For Publisher information, see DEVPED
Volume(issue)/page/year: 30,219,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 275 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)
V.1-98, 1953-86. For Publisher information, see DEVPED
Volume(issue)/page/year: 30,219,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Unreported
Rodent - rat
660 mg/kg
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 21,25A,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 262 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 23,115,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1321 mg/kg
SEX/DURATION
: female 8-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,
NY
10003) V.11906/08- Volume(issue)/page/year: 136,219,1960
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 660 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
REFERENCE :
85HBAZ "Environmental Variables in Oral Disease; A Symposium Presented at
the Montreal Meeting of the American Association for the Advancement of
Science, 1964," Kreshover, S.J., et al., eds., Washington, DC, American
Assoc. for the Advancement of Science, 1966 Volume(issue)/page/year:
-,273,1966
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 220 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 35,105,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 330 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.11921Volume(issue)/page/year: 41,141,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 28 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.11921Volume(issue)/page/year: 41,141,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 220 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 9,191,1974
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 330 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 14,13,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 28 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.11921Volume(issue)/page/year: 41,141,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 110 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of
Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.11921Volume(issue)/page/year: 41,141,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 2750 ug/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,37A,1983
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Intraperitoneal
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 2750 ug/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,37A,1983
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 27500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,317,1978
*** REVIEWS ***
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 6(3),279,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80573
No. of Facilities: 221 (estimated)
No. of Industries: 4
No. of Occupations: 10
No. of Employees: 9773 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80573
No. of Facilities: 893 (estimated)
No. of Industries: 8
No. of Occupations: 23
No. of Employees: 18737 (estimated)
No. of Female Employees: 8842 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RHEIN
RTECS NUMBER
CHEMICAL NAME
: CA9516000
: 2-Anthracenecarboxylic acid,
9,10-dihydro-4,5-dihydroxy-9,10-dioxoCAS REGISTRY NUMBER
: 478-43-3
BEILSTEIN REFERENCE NO. : 2222155
REFERENCE
: 4-10-00-04088 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C15-H8-O6
MOLECULAR WEIGHT
: 284.23
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo* Cassic acid
* Chrysazin-3-carboxylic acid
* 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
* Monorhein
* Rheic acid
* Rhubarb Yellow
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard
International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.601987Volume(issue)/page/year: 61,153,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard
International
Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.601987Volume(issue)/page/year: 61,153,1987
RHENIUM(III) CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: VI0875000
: Rhenium trichloride
: 13569-63-6
LAST UPDATED
: 199809
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: Cl3-Re
MOLECULAR WEIGHT
: 292.55
WISWESSER LINE NOTATION : RE G3
SYNONYMS/TRADE NAMES :
* Rhenium chloride (ReCl3)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 57,321,1968
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 57,321,1968
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RHODAMINE 3G
RTECS NUMBER
CHEMICAL NAME
: DH0175000
: Benzoic acid,
o-(6-(ethylamino)-3-(ethylimino)-2,7-dimethyl-3H-xant
hen-9-yl)-, ethyl ester, monohydrochloride
CAS REGISTRY NUMBER
: 989-38-8
LAST UPDATED
: 199904
DATA ITEMS CITED
: 27
MOLECULAR FORMULA
: C28-H31-N2-O3.Cl
MOLECULAR WEIGHT
: 479.06
WISWESSER LINE NOTATION : T C666 BO EYJ EUN2 F1 IR BVO2& L1 MN1&1 &GH
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Aizen Rhodamine 6GCP
* Basic Red 1
* Basic Rhodamine Yellow
* Basic Rhodaminic Yellow
* Calcozine Red 6G
* Calcozine Rhodamine 6GX
* Cerven zasadita 1
* C.I. 45160
* C.I. Basic Red 1
* C.I. Basic Red 1, monohydrochloride
* Elcozine Rhodamine 6GDN
* Eljon Pink Toner
* Fanal Pink B
* Fanal Pink GFK
* Fanal Red 25532
* Flexo Red 482
* Heliostable Brilliant Pink B Extra
* Mitsui Rhodamine
* Mitsui Rhodamine 6GCP
* NCI-C56122
* Nyco Liquid Red GF
* Rh 6G
* Rhodamine 590 chloride
* Rhodamine 69DN Extra
* Rhodamine F4G
* Rhodamine F5G
* Rhodamine F5G chloride
* Rhodamine F 5GL
* Rhodamine 6G
* Rhodamine 6GB
* Rhodamine 6G (biological stain)
* Rhodamine 6GBN
* Rhodamine 6G chloride
* Rhodamine 6GCP
* Rhodamine 4GD
* Rhodamine 6GD
* Rhodamine GDN
* Rhodamine 5GDN
* Rhodamine 6 GDN
* Rhodamine 6 GDN Extra
* Rhodamine 6GEX ethyl ester
* Rhodamine 6G Extra
* Rhodamine 6G Extra Base
* Rhodamine 4GH
* Rhodamine 6GH
* Rhodamine 5GL
* Rhodamine 6G Lake
* Rhodamine 6GO
* Rhodamine 6GX
* Rhodamine J
* Rhodamine 6JH
* Rhodamine 7JH
* Rhodamine Lake Red 6G
* Rhodamine Y 20-7425
* Rhodamine ZH
* Rhodamine 6ZH
* Rhodamine 6Zh-DN
* Rhodamin 6G
* Silosuper Pink B
* Vali Fast Red 1308
* Xanthylium,
9-(2-(ethoxycarbonyl)phenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-364,1989
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Liver - other changes
Blood - other hemolysis with or without anemia
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 7(2),34,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6150 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
51,35,1990
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
2310 mg/kg/14D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-364,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10192 mg/kg/13W-C
TOXIC EFFECTS :
Blood - changes in spleen
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-364,1989
(Research
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 130 mg/kg/35D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 7(2),34,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 51 gm/kg/13W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-364,1989
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7725 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
(Research
NTP-TR-364,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
47,51,1956
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4 mg/kg
SEX/DURATION
: female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 33,67C,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2 mg/kg
SEX/DURATION
: female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
9,29,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2 mg/kg
SEX/DURATION
: female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 40,143,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2 mg/kg
SEX/DURATION
: female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 40,143,1989
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 20 nmol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,4412,1979
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2500 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-364,1989
(Research
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 90 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,4412,1979
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 20 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-364,1989
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Sister chromatid exchange
: Rodent - hamster Ovary
: 19900 ug/L
(Research
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-364,1989
(Research
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 16,233,1978
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 16,233,1978
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2209
No. of Facilities: 917 (estimated)
No. of Industries: 20
No. of Occupations: 21
No. of Employees: 15041 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2209
No. of Facilities: 2416 (estimated)
No. of Industries: 27
No. of Occupations: 32
No. of Employees: 41538 (estimated)
No. of Female Employees: 8238 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Studies (feed);equivocal evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-364,1989
NTP Carcinogenesis Studies (feed);no evidence:mouse
(Research
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-364,1989
RHODAMINE B
RTECS NUMBER
CHEMICAL NAME
(Research
: BP3675000
: Ammonium,
(9-(o-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-yl
idene)diethyl-, chloride
CAS REGISTRY NUMBER
: 81-88-9
LAST UPDATED
: 199710
DATA ITEMS CITED
: 29
MOLECULAR FORMULA
: C28-H31-N2-O3.Cl
MOLECULAR WEIGHT
: 479.06
WISWESSER LINE NOTATION : T C666 BO EYJ EUK2&2 IR BVQ& MN2&2 &Q &G
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acid Brilliant Pink B
* ADC Rhodamine B
* Aizen Rhodamine BH
* Akiriku Rhodamine B
* Aizen Rhodamine BHC
* Basic Violet 10
* Brilliant Pink B
* Calcozine Red BX
* Calcozine Rhodamine BXP
* 9-o-Carboxyphenyl-6-diethylamino-3-ethylimino-3-isoxanthene,
3-ethochloride
* (9-(o-Carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene)
diethylammonium chloride
* Cerise Toner X1127
* C.I. 749
* C.I. 45170
* C.I. Basic Violet 10
* C.I. Food Red 15
* Cogilor Red 321.10
* Cosmetic Brilliant Pink Bluish D Conc
* D & C Red No.19
* Diabasic Rhodamine B
* Edicol Supra Rose B
* Edicol Supra Rose BS
* Elcozine Rhodamine B
* Eriosin Rhodamine B
* FD&C Red No. 19
* Food Red 15
* Geranium Lake N
* Hexacol Rhodamine B Extra
* Ikada Rhodamine B
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Iragen Red L-U
Mitsui Rhodamine BX
11411 Red
Red No. 213
Rheonine B
Rhodamine B
Rhodamine B 20-7470
Rhodamine BA
Rhodamine BA Export
Rhodamine B chloride
Rhodamine B Extra
Rhodamine B Extra M 310
Rhodamine B Extra S
Rhodamine BF
Rhodamine B500
Rhodamine B500 hydrochloride
Rhodamine BN
Rhodamine BS
Rhodamine BX
Rhodamine BXL
Rhodamine BXP
Rhodamine FB
Rhodamine Lake Red B
Rhodamine O
Rhodamine, tetraethylRhodamine S
Sicilian Cerise Toner A-7127
Symulex Magenta F
Symulex Pink F
Symulex Rhodamine B Toner F
Takaoka Rhodamine B
Tetraethyldiamino-o-carboxyphenyl xanthenyl chloride
Tetraethylrhodamine
Violet zasadita 10
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,8,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 112 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine,
75008
Paris, France) V.11978- Volume(issue)/page/year: 1,23,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 89 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
3,696,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 887 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine,
75008
Paris, France) V.11978- Volume(issue)/page/year: 1,23,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 144 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
60LFAC "Recent Advances of Chemistry and Molecular Biology in Cancer
Research, Insternational Symposium on Recent Advances of Chemistry and
Molecular Biology in Cancer Research, Held in Beijing/China, July
23rd-26th,
1991" Dai Qianhuan, Margaret-Ann Armour and Zheng Qingying eds. Science
Press (Beijing) 1993 Volume(issue)/page/year: -,281,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OKEHDW Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Koshu Eisei
Hen.
Research Reports of the Oaka Prefectural Institute of Public Health,
Public
Health Section. (Osaka-furitsu Koshu Eisei Kenkyusho, 1-3-69 Nakamichi,
Higashinari-ku, Osaka, 537, Japan) No.31966Volume(issue)/page/year:
(3),185,1953
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50400 mg/kg/12W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
3,696,1961
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 110 mg/kg/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 7(2),34,1963
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3600 mg/kg/68W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
47,51,1956
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3870 mg/kg/68W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
46,369,1955
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 60 mg/kg
SEX/DURATION
: female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 40,143,1989
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
66,181,1979
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 25 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,349,1991
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1000 ppm
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB
37005, Chicago, IL 60637) V.11867- Volume(issue)/page/year:
87,295,1953
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 900 umol/plate
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB
37005, Chicago, IL 60637) V.11867- Volume(issue)/page/year:
87,295,1953
TYPE OF TEST
TEST SYSTEM
: Cytogenetic analysis
: Rodent - hamster Ovary
DOSE/DURATION
: 20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 10 mg/L
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,41,1980
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Mammal - species unspecified Fibroblast
DOSE/DURATION
: 2 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
88,211,1981
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 16,221,1978
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 16,221,1978
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84376
No. of Facilities: 3759 (estimated)
No. of Industries: 38
No. of Occupations: 37
No. of Employees: 40674 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84376
No. of Facilities: 12726 (estimated)
No.
No.
No.
No.
of
of
of
of
Industries: 91
Occupations: 88
Employees: 198323 (estimated)
Female Employees: 75440 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; B
subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
RHODIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* RH
* Rhodium, metal
:
:
:
:
:
:
:
:
VI9069000
Rhodium
7440-16-6
199907
23
Rh
102.91
RH
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 1 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 0.1 mg(Rh)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 0.1 mg(Rh)/m3 (fume)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 mg(Rh)/m3,
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 mg(Rh)/m3,fume and dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 mg/m3 JAN 1993
OEL-BELGIUM:TWA 1 mg/m3 JAN 1993
OEL-DENMARK: TWA 0.1 mg/m3, JAN1999
OEL-FINLAND:TWA 0.1 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg/m3;STEL 0.3 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO RHODIUM (as Rh), soluble compds-air:10H TWA 0.001 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO RHODIUM (as Rh)-air:10H TWA 0.1 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 67405
No. of Facilities: 201 (estimated)
No. of Industries: 5
No. of Occupations: 7
No. of Employees: 3399 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 67405
No. of Facilities: 1612 (estimated)
No. of Industries: 17
No. of Occupations: 27
No. of Employees: 12004 (estimated)
No. of Female Employees: 2078 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
RHODIUM CHLORIDE TRIHYDRATE
RTECS NUMBER
: VI9290000
CHEMICAL NAME
: Rhodium chloride, trihydrate
CAS REGISTRY NUMBER
: 13569-65-8
LAST UPDATED
: 199907
DATA ITEMS CITED
: 25
MOLECULAR FORMULA
: Cl3-Rh.3H2-O
MOLECULAR WEIGHT
: 263.32
WISWESSER LINE NOTATION : .RH..G3 QH3
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Rhodium(III) chloride trihydrate
* Rhodium trichloride trihydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 369 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
63,461,1982
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
88,165,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Rh)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 mg(Rh)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,222,1971
OSHA PEL (Gen Indu):8H TWA 0.001 mg(Rh)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.001 mg(Rh)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.001 mg(Rh)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.001 mg(Rh)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 mg(Rh)/m3 JAN 1993
OEL-BELGIUM:TWA 1 mg(Rh)/m3 JAN 1993
OEL-DENMARK: TWA 0.001 mg(Rh)/m3, JAN1999
OEL-FINLAND:TWA 0.001 mg(Rh)/m3;Skin JAN 1993
OEL-FINLAND:TWA 0.1 mg(Rh)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.001 mg(Rh)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 mg(Rh)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 mg(Rh)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.001 mg(Rh)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Rh)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.001 mg(Rh)/m3;STEL 0.003 mg(Rh)/m3
JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg(Rh)/m3;STEL 0.3 mg(Rh)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2970
No. of Facilities: 227 (estimated)
No. of Industries: 4
No. of Occupations: 4
No. of Employees: 448 (estimated)
RHODIUM(II) ACETATE DIMER DIHYDRATE
RTECS NUMBER
: VI9361000
CHEMICAL NAME
: Rhodium, tetrakis(mu-acetato)diCAS REGISTRY NUMBER
: 15956-28-2
LAST UPDATED
: 198909
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C8-H12-O8-Rh2
MOLECULAR WEIGHT
: 442.02
COMPOUND DESCRIPTOR
: Organometallic
SYNONYMS/TRADE NAMES :
* Dirhodium tetraacetate
* Rhodium acetate
* Rhodium acetate, dimer
* Rhodium diacetate dimer
* Tetraacetatodirhodium
* Tetrakis(acetato)dirhodium
* Tetrakis-(mu-acetato)dirhodium
* Tetrakis(acetato)dirhodium(II)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD10 - Lethal Dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 115 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 20,943,1977
RHODIUM(III) CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
VI9275000
Rhodium(III) chloride (1:3)
10049-07-7
199907
31
Cl3-Rh
209.26
RH G3
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Rhodium chloride
* Rhodium trichloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1302 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 21(7),55,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 198 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,589,1972
TYPE OF TEST
: LD10 - Lethal Dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 879 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 20,943,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 215 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,589,1972
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 940 mg/kg/66W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - leukemia
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.11928- Volume(issue)/page/year: 101,1431,1971
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 16741 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 7,21,1964
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,109,1980
*** REVIEWS ***
ACGIH TLV-TWA 0.01 mg(Rh)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 mg(Rh)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,222,1971
OSHA PEL (Gen Indu):8H TWA 0.001 mg(Rh)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.001 mg(Rh)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.001 mg(Rh)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.001 mg(Rh)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 mg(Rh)/m3 JAN 1993
OEL-BELGIUM:TWA 1 mg(Rh)/m3 JAN 1993
OEL-DENMARK: TWA 0.001 mg(Rh)/m3, JAN1999
OEL-FINLAND:TWA 0.001 mg(Rh)/m3;Skin JAN 1993
OEL-FINLAND:TWA 0.1 mg(Rh)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.001 mg(Rh)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 mg(Rh)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 mg(Rh)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.001 mg(Rh)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Rh)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.001 mg(Rh)/m3;STEL 0.003 mg(Rh)/m3
JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg(Rh)/m3;STEL 0.3 mg(Rh)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RIBOFLAVIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
VJ1400000
Riboflavine
83-88-5
199701
11
C17-H20-N4-O6
376.41
T C666 BN DNVMV INJ B1YQYQYQ1Q L1 M1
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Beflavine
* 6,7-Dimethyl-9-D-ribitylisoalloxazine
* Flavaxin
* Flaxain
* Hyflavin
* HYRE
* Isoalloxazine, 7,8-dimethyl-10-D-ribityl* Isoalloxazine, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)* Lactoflavin
* Lactoflavine
* Ribipca
* Riboderm
* Riboflavin
* Riboflavinequinone
* Vitamin B2
* Vitamin G
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 76,75,1942
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 560 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Kidney, Ureter, Bladder - urine volume decreased
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 76,75,1942
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 76,75,1942
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 46A,20,1969
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 76,75,1942
V.1-
1909/10-
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 ug/plate
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of
Tokyo
Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei
Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan)
V.11949/50- Volume(issue)/page/year: 37,447,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 300 mg/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 111971- Volume(issue)/page/year:
27,95,1981
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,1,1997
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 67410
No. of Facilities: 1890 (estimated)
No. of Industries: 8
No. of Occupations: 22
No. of Employees: 24319 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 67410
No. of Facilities: 2923 (estimated)
No. of Industries: 15
No. of Occupations: 45
No. of Employees: 74790 (estimated)
No. of Female Employees: 35023 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RIBONUCLEASE T1
RTECS NUMBER
: RF0753000
CHEMICAL NAME
: Nuclease, guanyloriboCAS REGISTRY NUMBER
: 9026-12-4
LAST UPDATED
: 199410
DATA ITEMS CITED
: 1
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Asperigillus oryzae ribonuclease
* Binase
* E.C.2.7.7.26
* E.C.3.1.4.8
* Guanyloribonuclease
* Guanyl-specific RNase
* Ribonuclease C2
* Ribonuclease Ch
* Ribonuclease F1
* Ribonuclease N1
* Ribonuclease N3
* Ribonuclease PPI
* Ribonuclease T1
* Ribonuclease U1
* RNase F1
* RNase G
* RNase Sa
* RNase T1
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 mg/L
REFERENCE :
MGMVDU Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya.
(Molekuliarnaia Genetika, Mikrobiologiia i Virusologiia, 117 GSP-7,
Moskva
B-246, USSR) No.11983- Volume(issue)/page/year: 10,22,1991
RIBONUCLEIC ACID
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
SYNONYMS/TRADE NAMES :
* Pentosenucleic acids
* Ribonucleic acids
* RNA
RF0772520
Nucleic acids, ribo63231-63-0
199701
2
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.11877Volume(issue)/page/year: 60,251,1954
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RIBOSE
RTECS NUMBER
: VJ2275000
CHEMICAL NAME
: Ribose, DCAS REGISTRY NUMBER
: 50-69-1
BEILSTEIN REFERENCE NO. : 1723081
REFERENCE
: 4-01-00-04211 (Beilstein Handbook Reference)
LAST UPDATED
: 199801
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C5-H10-O5
MOLECULAR WEIGHT
: 150.15
COMPOUND DESCRIPTOR
: Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Ribose
* D-Ribose
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intrauterine
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5045 ug/kg
SEX/DURATION
: female 2 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
1980Volume(issue)/page/year: 11(4),7,1991
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 50 mmol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 138,673,1986
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 30 mmol/L
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 180,246,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1001
No. of Facilities: 439 (estimated)
No. of Industries: 2
No. of Occupations: 8
No. of Employees: 4169 (estimated)
No. of Female Employees: 2111 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RICINOLEIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
VJ3150000
Ricinoleic acid
141-22-0
199701
4
C18-H34-O3
298.52
QV8U2YQ6
Tumorigen
Natural Product
SYNONYMS/TRADE NAMES :
* Acide ricinoleique
* 12-Hydroxy-cis-9-octadecenoic acid
* Kyselina 12-hydroxy-9-oktadecenova
* Kyselina ricinolova
* 9-Octadecenoic acid, 12-hydroxy-, (Z)* Oleic acid, 12-hydroxy-
* Ricinic acid
* Ricinolic acid
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 390 mg/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 137,760,1943
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83687
No. of Facilities: 1453 (estimated)
No. of Industries: 25
No. of Occupations: 27
No. of Employees: 16450 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83687
No. of Facilities: 41 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 654 (estimated)
No. of Female Employees: 70 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RIFAMPICIN
RTECS NUMBER
CHEMICAL NAME
: VJ7000000
: Rifomycin SV,
8-(N-(4-methyl-1-piperazinyl)formidoyl)CAS REGISTRY NUMBER
: 13292-46-1
LAST UPDATED
: 199812
DATA ITEMS CITED
: 62
MOLECULAR FORMULA
: C43-H58-N4-O12
MOLECULAR WEIGHT
: 823.05
WISWESSER LINE NOTATION : T C6 B65-24- A D E 2BC G& AV LO NO F&VM OU B&U D&U
MH&&&TJ DQ GQ IQ JI MI QO1 R1 SOV1 T1 UQ
COMPOUND DESCRIPTOR
: Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Archidyn
* Arficin
* Dione 21-acetate
* L-5103
* 3-(4-Methylpiperazinyliminomethyl)-rifamycin SV
* 8-(4-Methylpiperazinyliminomethyl) rifamycin SV
* 8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
* NSC 113926
* R/AMP
* Rifa
* Rifadin
* Rifadine
* Rifagen
* Rifaldazin
* Rifaldazine
* Rifampicin
* Rifampicine
* Rifampicin SV
* Rifampicinum
* Rifampin
* Rifamycin AMP
* Rifamycin, 3-(((4-methyl-1-piperazinyl)imino)methyl)* Rifaprodin
* Rifinah
* Rifobac
* Rifoldin
* Rifoldine
* Riforal
* Rimactan
* Rimactane
* Rimactazid
* Rimactizid
* Sinerdol
* Tubocin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 814 mg/kg/15W-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - hematuria
REFERENCE :
AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc.,
Journal Subscription Dept., POB 6280, Duluth, MN 55806)
Volume(issue)/page/year: 32,533,1998
V.1-
1981-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 744 mg/kg/9W-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc.,
Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.11981Volume(issue)/page/year: 31,108,1998
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 504 mg/kg/42D-I
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
Blood - aplastic anemia
REFERENCE :
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.11946- Volume(issue)/page/year: 87,459,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 315 mg/kg/5W-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63141) 1979Volume(issue)/page/year: 17,303,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Sense Organs and Special Senses (Eye) - iritis
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
2,1189,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 13 mg/kg/2D
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
1,199,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 857 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Gastrointestinal - other changes
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
240,2283,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 23,257,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 511 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 23,257,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 534 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)
Volume(issue)/page/year: 23,242,1970
V.21-
1968-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher
information, see CRASEV. Volume(issue)/page/year: 269,2147,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 416 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For
publisher
information, see CHTHBK. Volume(issue)/page/year: 12,155,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 621 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 23,242,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel,
Switzerland)
V.1-16, 1954-70. For publisher information, see ANBCB3.
Volume(issue)/page/year: 16,316,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel,
Switzerland)
V.1-16, 1954-70. For publisher information, see ANBCB3.
Volume(issue)/page/year: 16,316,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 639 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel,
Switzerland)
V.1-16, 1954-70. For publisher information, see ANBCB3.
Volume(issue)/page/year: 16,316,1970
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 gm/kg/8D-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 23,454,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 17500 mg/kg/5W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 23,257,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 72800 mg/kg/26W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 23,257,1970
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 mg/m3/4H/17W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(11),52,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 280 mg/kg/14D-I
TOXIC EFFECTS :
Liver - change in gall bladder structure or function
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and
Medical
Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.30-V.32,
1985-1987 Volume(issue)/page/year: 30,185,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 7800 mg/kg/26W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Related to Chronic Data - death
REFERENCE :
ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel,
Switzerland)
V.1-16, 1954-70. For publisher information, see ANBCB3.
Volume(issue)/page/year: 16,316,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 19005 mg/kg/26W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel,
Switzerland)
V.1-16, 1954-70. For publisher information, see ANBCB3.
Volume(issue)/page/year: 16,316,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 11200 mg/kg/4W-I
TOXIC EFFECTS :
Liver - jaundice, other or unclassified
Related to Chronic Data - death
REFERENCE :
ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel,
Switzerland)
V.1-16, 1954-70. For publisher information, see ANBCB3.
Volume(issue)/page/year: 16,316,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5600 mg/kg/8D-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 23,454,1970
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5 mg/m3/4H/17W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(11),52,1981
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8400 mg/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
43,293,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1400 mg/kg
SEX/DURATION
: female 4-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher
information, see CRASEV. Volume(issue)/page/year: 269,2147,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3200 mg/kg
SEX/DURATION
: female 1-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher
information, see CRASEV. Volume(issue)/page/year: 269,2147,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4 gm/kg
SEX/DURATION
: female 2-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel,
Switzerland)
V.1-16, 1954-70. For publisher information, see ANBCB3.
Volume(issue)/page/year: 16,316,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 800 mg/kg
SEX/DURATION
: female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
PRTUAX Problemy Tuberkuleza. Problems of Tuberculosis. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11923Volume(issue)/page/year: 69(2),67,1991
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6100 ug/m3/24H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 25,280,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2200 mg/kg
SEX/DURATION
: female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher
information, see CRASEV. Volume(issue)/page/year: 269,2147,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2600 mg/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70). (Basel,
Switzerland)
V.1-16, 1954-70. For publisher information, see ANBCB3.
Volume(issue)/page/year: 16,316,1970
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: DNA repair
: Bacteria - Salmonella typhimurium
: 1 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,286,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 mg/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.11916- Volume(issue)/page/year:
145,1334,1981
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 6 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Mutation test systems - not otherwise specified
: Bacteria - Escherichia coli
: 80 mg/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 24,1105,1968
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 200 mg/L
REFERENCE :
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I
St., NW, Washington, DC 20006) V.11916- Volume(issue)/page/year:
115,786,1973
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 ug/kg
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968Volume(issue)/page/year: 43,88,1990
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 60 ng/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,2819,1983
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 600 ng/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
1964-
Volume(issue)/page/year: 97,1,1982
: Mutation test systems - not otherwise specified
: Bacteria - Bacillus subtilis
: 100 ug/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 24,1105,1968
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 200 mg/L
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB
5050,
Tokyo International, Tokyo 100-31, Japan) V.251961Volume(issue)/page/year: 41,383,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 100 mg/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 79,1101,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 25 mg/L
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.11972Volume(issue)/page/year: 17,838,1980
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,286,1974
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 250 mg/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 22,350,1984
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: DNA inhibition
: Human Lymphocyte
: 100 mg/L
1963-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 60,96,1974
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Mutation test systems - not otherwise specified
: Human HeLa cell
: 150 mg/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 30,484,1974
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 250 mg/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.11963Volume(issue)/page/year: 22,350,1984
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Mutation test systems - not otherwise specified
: Human Cells - not otherwise specified
: 150 mg/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 30,484,1974
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 25 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
48,215,1977
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Cytogenetic analysis
: Human Cells - not otherwise specified
: 78 mg/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 30,484,1974
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
27,2139,1978
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 5 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
141,171,1984
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,243,1980
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,243,1980
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)
V.33-115, 1886-1973. Volume(issue)/page/year: 115,1685,1973
TOXICOLOGY REVIEW
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK)
Volume(issue)/page/year: 2,1285,1980
V.1-
1823-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4882
No. of Facilities: 141 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 928 (estimated)
No. of Female Employees: 656 (estimated)
RNASE
RTECS NUMBER
: RF0760000
CHEMICAL NAME
: Nuclease, riboCAS REGISTRY NUMBER
: 9001-99-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 10
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Alkaline ribonuclease
*
*
*
*
*
*
*
E.C. 2.7.7.16
E.C. 3.1.4.22
Pancreatic ribonuclease
Ribonuclease
Ribonuclease A
Ribonuclease I
Ribonucleic phosphatase
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 392 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
Nucleases: Biological Function and Practical Applications," Berdyshev,
G.D.,
et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
Volume(issue)/page/year: -,56,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
Nucleases: Biological Function and Practical Applications," Berdyshev,
G.D.,
et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
Volume(issue)/page/year: -,56,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
Nucleases: Biological Function and Practical Applications," Berdyshev,
G.D.,
et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
Volume(issue)/page/year: -,56,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
Nucleases: Biological Function and Practical Applications," Berdyshev,
G.D.,
et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
Volume(issue)/page/year: -,56,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
Nucleases: Biological Function and Practical Applications," Berdyshev,
G.D.,
et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
Volume(issue)/page/year: -,56,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 355 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
54IIAL "Nukleazy: Biologicheskaya Rol i Prakticheskoe Ispol'zovanie.
Nucleases: Biological Function and Practical Applications," Berdyshev,
G.D.,
et al., eds., Kiev, USSR, Izdatel'stvo Naukova Dumka, 1985
Volume(issue)/page/year: -,56,1985
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 40 mg/L
REFERENCE :
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc.,
Service
Center, 44 Hartz Way, Secacus, NJ 07094) V.951974Volume(issue)/page/year: 122,161,1979
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 40 mg/L
REFERENCE :
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc.,
Service
Center, 44 Hartz Way, Secacus, NJ 07094) V.951974Volume(issue)/page/year: 122,161,1979
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation test systems - not otherwise specified
: Microorganism - not otherwise specified
: 40 mg/L
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc.,
Service
Center, 44 Hartz Way, Secacus, NJ 07094) V.951974Volume(issue)/page/year: 122,161,1979
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
ROLITETRCYCLINE
RTECS NUMBER
CHEMICAL NAME
: QI9150000
: 2-Naphthacenecarboxamide,
4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,
10,12,12apentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmet
hyl)CAS REGISTRY NUMBER
: 751-97-3
LAST UPDATED
: 199609
DATA ITEMS CITED
: 11
MOLECULAR FORMULA
: C27-H33-N3-O8
MOLECULAR WEIGHT
: 527.63
WISWESSER LINE NOTATION : L E6 C666 BV FV CU GUTTT&J DQ EQ HQ IN1&1 MQ M1 RQ
GVM1- AT5NTJ
COMPOUND DESCRIPTOR
: Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Bristacin
* Pirrolidinometil-tetraciclina
* Prm-TC
* Pyrrolidino-methyl-tetracycline
* N-(Pyrrolidinomethyl)tetracycline
* N-(1-Pyrrolidinylmethyl)-tetracycline
* Reverin
* Rolitetracycline
* SQ 15,659
* Superciclin
* Synotodecin
* Syntetrex
* Syntetrin
* Tetracycline, pyrrolidinomethyl* Transcycline
* Velacicline
* Velacycline
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 16,33,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3846486
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 9,63,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 93 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,914,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,914,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - mouse
1400 mg/kg/7D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 25,95,1972
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 91 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,54,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 91 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland) V.11969/70Volume(issue)/page/year: 4,54,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 450 mg/kg
SEX/DURATION
: female 8-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 3,75,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 300 mg/kg
SEX/DURATION
: female 8-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 3,75,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 900 mg/kg
SEX/DURATION
: female 8-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 3,75,1972
ROSE BENGAL
RTECS NUMBER
CHEMICAL NAME
: LM5920000
: Fluorescein,
4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-,
disodium
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
salt
632-69-9
199701
5
C20-H2-Cl4-I4-O5.2Na
1017.60
Tumorigen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Food Red Color No. 105, sodium salt
* Food Red No. 105, sodium salt
* Rose bengal sodium
* R105 sodium
*
9-(3',4',5',6'-Tetrachloro-o-carboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo3-isoxanthone 2Na
* 4,5,6,7-Tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 707 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 77,277,1986
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 650 mg/kg
SEX/DURATION
: female 8-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 24,391,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 mg/kg
SEX/DURATION
: female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 24,391,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 20 gm/kg
SEX/DURATION
: female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 24,391,1982
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
ROSIN
RTECS NUMBER
: VL0480000
CHEMICAL NAME
: Rosin
CAS REGISTRY NUMBER
: 8050-09-7
LAST UPDATED
: 199712
DATA ITEMS CITED
: 5
SYNONYMS/TRADE NAMES :
* BALS 3A
* Bandis G100
* EM 3
* Highrosin
* Hongkong rosin WW
* KE 709
* Rondis R
* Rosin core solder pyrolysis products
* Rosin WW
* Shiragiku rosin
* Yellow resin
*** REVIEWS ***
ACGIH TLV-reduce to as low as possible
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2732
No. of Facilities: 511 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 511 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6806
No. of Facilities: 758 (estimated)
No. of Industries: 9
No. of Occupations: 14
No. of Employees: 8324 (estimated)
No. of Female Employees: 2339 (estimated)
NOES - National Occupational
NOES Hazard Code - 80164
No. of Facilities: 27401
No. of Industries: 199
No. of Occupations: 133
No. of Employees: 566016
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
212612 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RUBIDIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
:
:
:
:
:
:
:
:
VL8500000
Rubidium
7440-17-7
199710
5
Rb
85.47
.RB
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du
Systeme
Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger,
1948
Volume(issue)/page/year: -,704,1948
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 67541
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 56 (estimated)
No. of Female Employees: 7 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
RUBIDIUM CARBONATE
RTECS NUMBER
: FG0650000
CHEMICAL NAME
: Carbonic acid, dirubidium salt
CAS REGISTRY NUMBER
: 584-09-8
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C-O3.2Rb
MOLECULAR WEIGHT
: 230.95
SYNONYMS/TRADE NAMES :
* Dirubidium carbonate
* Dirubidium monocarbonate
* Rubidium carbonate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2625 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(9),55,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 450 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(9),55,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RUBIDIUM CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
VL8575000
Rubidium chloride
7791-11-9
199701
11
Cl-Rb
120.92
RB G
Mutagen
Reproductive Effector
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(5),76,1988
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(9),55,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
20PKA3 "Novye Dannye Po Toksikologii Redkikh Metalov Ikh Soedinenii," New
Data on the Toxicology of Rare Metals and Their Compounds, Izrael'son,
Z.I.,
ed., Moscow, Izdatel'stvo "Meditsina," 1967
-,56,1967
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1149 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
(Paris, France) V.1-261, 1835-1965. For publisher information, see
CRASEV.
Volume(issue)/page/year: 256,1043,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 233 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
56(4),118S,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
56(4),118S,1960
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8560 ug/kg/31W-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - changes in spleen
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
Volume(issue)/page/year: 53(5),76,1988
V.1-
1936-
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 84 mg/kg
SEX/DURATION
: female 30 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(5),76,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 8400 ug/kg
SEX/DURATION
: female 30 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(5),76,1988
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 50 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
1,21,1986
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RUBIDIUM HYDROXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
:
:
:
:
VL8750000
Rubidium hydroxide
1310-82-3
199701
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
: 4
: H-O-Rb
: 102.48
: RB Q
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 586 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - other changes
Skin and Appendages - hair
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
32,239,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
20PKA3 "Novye Dannye Po Toksikologii Redkikh Metalov Ikh Soedinenii," New
Data on the Toxicology of Rare Metals and Their Compounds, Izrael'son,
Z.I.,
ed., Moscow, Izdatel'stvo "Meditsina," 1967 Volume(issue)/page/year:
-,56,1967
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4532
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 7 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RUBIDIUM NITRATE
RTECS NUMBER
CHEMICAL NAME
: QV0900000
: Nitric acid, rubidium salt
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* Rubidium nitrate
:
:
:
:
:
13126-12-0
199701
3
N-O3.Rb
147.48
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4625 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(9),55,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1425 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(9),55,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RUBIDIUM SULFATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: WS8350000
: Sulfuric acid, dirubidium salt
: 7488-54-2
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* Dirubidium sulfate
* Rubidium sulfate
:
:
:
:
199701
3
O4-S.2Rb
267.00
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4594 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(9),55,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(9),55,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
RUTHENIUM(III) CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: VM2650000
: Ruthenium chloride
: 10049-08-8
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: Cl3-Ru
MOLECULAR WEIGHT
: 207.42
WISWESSER LINE NOTATION : .RU..G3
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Ruthenium trichloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY