HaiFang Yin, PhD, Professor
Principle Investigator, Tianjin-Oxford Joint laboratory of Gene Therapy
Tianjin Research Center of Basic Medical Science, Tianjin Medical University,
22 Qixiangtai Road, Heping District, Tianjin 300070, China
Tel: 0086-22-23542076 or 0086-15122025515
Email: HAIFANGYIN@GMAIL.COM
Education:
Year
2003
2000
1997
Degree
PhD
MS
BSc
Field of Study
Institution
Biochemistry and Molecular Biology China Agricultural University, China
Microbiology
ShenYang Agricultural University，China
Agronomy
Inner Mongolia National University, China
Position and Employment:
Year (s)
Position
2004 - 2005
Postdoctoral Research Assistant, Clinical Science Center (CSC), Medical
Research Council (MRC), Imperial College London, School of Medicine,
Hammersmith Hospital, UK
2005 - 2009
Postdoctoral Research Fellow and Team leader, Department of Physiology,
Anatomy and Genetics, University of Oxford, Oxford, UK
2010 - Present
Professor and Principal Investigator (PI), Tianjin Research Center of Basic
Medical Science, Tianjin Medical University, Tianjin, China
Professional Membership, Honors and other positions held:
Membership of learned societies:
2007 - 2008 Biochemical Society
2007 - 2009 American Society of Gene Therapy
2008 - 2010 Oligonucleotide Therapeutic Society
2008 - 2010 World Muscle Society
2006 - 2007
2008 - 2009
2008
2008
2008 - 2010
2009 - 2011
Merit Award, University of Oxford, Oxford, UK
Merit Award, University of Oxford, Oxford, UK
Best Presentation Award, 13th World Muscle Society Conference
Best Poster Prize, 6th Action Duchenne Conference
Director of Sophos Therapeutic Biotech Company
Fullford Junior Research Fellowship of Somerville College, University of Oxford, UK
Patents:
HaiFang Yin, Matthew Wood. Therapeutic Application of Peptide Nucleic Acid Antisense
Oligonucleotide Chemistry for exon skipping in DMD (2007, N102674; PCT/GB09/000379)
HaiFang Yin, Matthew Wood. Conjugate for delivery of biologically active compounds (2009,
N108511A US)
Mike Gait, Andrey Arzumanov, Gabriela Ivanova, Donna William, David Owen, Bernard Lebleu,
Rachida Abes, HaiFang Yin and Matthew Wood. Biostabilized nuclear delivery peptide. (2009,
A813/2179; PCT/GB2009/001261)
Recent Publications:
1. HaiFang Yin, Amer F Saleh, Corinne Betts, Patrizia Camelliti, Yiqi Seow, Shirin Ashraf,
Andrey Arzumanov, Michael Gait and Matthew Wood. Novel peptides direct high efficiency
oligonucleotide-mediated dystrophin exon skipping in heart and phenotypic correction in mdx
mice. (Submitted to Science Translational Medicine).
2. Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Matthew Wood. Exosome-targeted systemic
delivery of siRNA to the brain. (Nature Biotechnology 2010 In Revision).
3. Thomas Roberts, Yiqi Seow, HaiFang Yin, Graham McClorey, Nigel J Saunders, Matthew
Wood. MicroRNA expression profiling in mdx mouse muscle and heart implicates miR-142-3p
in Duchenne muscular dystrophy (Submitted to Neuromuscular Disorders).
4. HaiFang Yin*, Hong M Moulton, Corinne Betts, Thomas Merritt, Yiqi Seow,Shirin
Ashraf,QingSong Wang,Jordan Boutilier, Patrick Iverson and Matthew Wood. Functional and
phenotypic rescue of dystrophin-deficient mdx mice by a chimeric peptide-PMO oligomer. (2010)
Molecular Therapy. 2010 August 10 [Epub ahead of print]
5. Yiqi Seow, HaiFang Yin, Matthew Wood. Identification of novel muscle targeting peptides in
mdx mice. (2010) Peptides. 2010 Jul 16. [Epub ahead of print]
6. HaiFang Yin*, QingSong Wang, Patrizia Camelliti, Corinne Betts, Hong M Moulton, Hyunil
Lee, Amer F Saleh, Michael J Gait and Matthew Wood. In vitro evaluation of novel antisense
oligonucleotides is predictive of in vivo exon skipping activity for DMD.(2010) Journal of Gene
Medicine,12(4):354-364, Epub March 16.
7. Matthew Wood,Michael J Gait and HaiFang Yin. RNA-targted splice-correction therapy for
neuromuscular disease. (2010) Brain,133(Pt4): 957-972, Epub 2010 Feb 11.
8. HaiFang Yin*, Corinne Betts, Amer F Saleh, Gabriella Ivanova, Hyunil Lee, Yiqi Seow, Dalsoo
Kim, Michael J Gait and Matthew Wood. Optimization of peptide nucleic acid antisense
oligonucleotide for local and systemic dystrophin correction in mdx mouse.(2010) Molecular
Therapy, 18(4):819-827, Epub 2010 Jan 12.
9. HaiFang Yin*, Hong M Moulton, Corinne Betts and Matthew Wood. CPP directed
oligonucleotide exon skipping in animal models of Duchenne muscular dystrophy. CellPenetrating Peptides: Methods and Protocols in Molecular Biology (book chapter 23),
Springer/Humana Press.（In Press）
10. HaiFang Yin, Hong M Moulton, Corinne Boyd, Yiqi Seow, Jordan Boutilier, Patrick Iverson,
Ryszard Kole and Matthew Wood. A muscle-targeting peptide domain directs systemic antisense
oligonucleotide-induced splice correction of the DMD gene and functional restoration in
dystrophin-deficient mdx mice. (2009) Human Molecular Genetics, 18(22):4405-4414. Epub
2009 August 18.
11. Matthew Wood, HaiFang Yin and Michael Gait. Muscle and heart targeted oligonucleotide
splice correction for duchenne muscular dystrophy. (2009) Human Gene Therapy, 20(11):15001501.
12. Gabriela D. Ivanova, Andrey Arzumanov, Rachida Abes, HaiFang Yin, Matthew Wood,
Bernard Lebleu and Michael J. Gait. Improved cell-penetrating peptide-PNA conjugates for
splicing redirection in HeLa cells and exon skipping in mdx mouse muscle. (2008) Nucleic Acids
Research, 36(20):6418-28. Epub 2008 Oct 8.
13. HaiFang Yin, Hong M. Moulton, Yiqi Seow, Corinne Boyd, Jordan Boutilier, Patrick Iverson
and Matthew Wood. Cell-penetrating peptide conjugated antisense oligonucleotides restore
systemic muscle and cardiac dystrophin expression and function. (2008) Human Molecular
Genetics, 17(24):3909-18. Epub 2008 Sep 10.
14. HaiFang Yin, Yiqi Seow, Hong M. Moulton, Patrick Iverson, Jordan Boutilier and Matthew
Wood. Restoration of dystrophin expression in mdx mouse by peptide-conjugated antisense
oligonucleotides. (2008) Neuromuscular Disorders, 18(9-10):759-759.
15. Gabriela D. Ivanova, Martin M Fabani, Andrey Arzumanov, Rachida Abes, HaiFang Yin,
Bernard Lebleu, Matthew Wood and Michael J. Gait. PNA-peptide conjugates as intracellular
gene control agents. Nucleic Acids Symp Ser (Oxf). 2008; (52):31-2.
16. HaiFang Yin, QiLong Lu, Matthew Wood. Effective exon skipping and restoration of
dystrophin by peptide nucleic acid antisense oligonucletides in mdx mice. (2008) Molecular
Therapy, 16(1):38-45.
17. Matthew Wood, HaiFang Yin, Graham McClorey. Modulating the Expression of Disease Genes
with RNA-Based Therapy. (2007) PLoS Genetics, 3(6): 0845-0854.
18. Julia Alter, Fang Lou, Adam Rabinowitz, HaiFang Yin, Jeffrey Rosenfeld, Steve D Wilton,
Terence A Partridge, QiLong Lu. Systemic delivery of morpholino oligonucleotide restores
dystrophin expression bodywide and improves dystrophic pathology. (2006) Nature Medicine,
12: 175 – 177.
19. Julia Alter, Fang Lou, Adam Rabinowitz, HaiFang Yin, Jeffrey Rosenfeld, Steve D Wilton,
Terence A Partridge, QiLong Lu. Systemic delivery of antisense morpholino oligomers produces
expression of dystrophin and restoration of function in widespread muscles of the mdx mouse.
(2006) Neuromuscular Disorders, 16: S159-S159.
20. HaiFang Yin, BaoLiang Fan, Bin Yang, YuFang Liu, Jian Luo, XinHua Tian, Ning Li. Cloning
of pig parotid secretory protein gene upstream promoter and the establishment of a transgenic
mouse model expressing bacterial phytase for agricultural phosphorus pollution control. (2006)
Journal of Animal Science. 84(3):513-9.
21. QiLong Lu, Adam Rabinowitz, , YunChao Chen, Yokota Toshifumi, HaiFang Yin, Julia
Alter, George Bou-Gharios, Terry Partridge. Systemic Delivery of Antisense oligoribonucleotide
restores dystrophin expression in body-wide skeletal muscles. (2005) Proc. Natl. Acad. Sci. USA.
102(1): 198-203.
22. HaiFang Yin, ZhiHui Zhao, BaoLiang Fan, ZhaoLiang Liu, Wei Lu and Ning Li. cDNA
Cloning, Genomic Structure, Chromosomal Mapping and Expression Analysis of Parotid
Secretory Protein in Pig. (2004) Genomics. 83 (1) 9-18.