Curriculum Vitae Mohsen Tafaghodi (Pharm.D., Ph.D.) Associate Professor in Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad-Iran P.O. Box: 91775-1365 Phone: ++98-511-8823255-66 (Office) Fax: ++98-511-8823251 E-mail: tafaghodim@mums.ac.ir Education and training Pharm.D.: School of Pharmacy, Mashhad University of Medical Sciences (1991-1997). Ph.D. (Pharmaceutics): School of Pharmacy, Mashhad University of Medical Sciences (1997-2003). Ph.D. thesis title: Nasal immunization using biodegradable microspheres and liposomes: Tetanus toxoid as a model Research fellowships: 1- School of Pharmacy, University of Alberta, Canada (cancer vaccination using nanoand microparticulate drug delivery systems). 2- Leiden/Amsterdam center for Drug Research, University of Leiden, Netherland (preparation and characterization and in vivo study of TMC:HBsAg and chitosan:HBsAg nanoparticles as a nasal delivery /adjuvant system) Research Interest - Mucosal and systemic vaccine and drug delivery by nanoparticulate and microparticulate delivery systems (nanospheres, microspheres and liposomes) Honors & Awards Honored investigator (student) in medicinal sciences, Ferdowsi Festival, Mashhad, 2001 (Offered by MUMS and FUM). Honored Pharmacist, Mashhad, 2002 (Offered by Khorasan Association of Pharmacists). The best presentation in 8th Iranian Seminar of Pharmaceutical Scientists (Ph.D. student), Shiraz, 2002 (Offered by Iranian Association of Pharmaceutical Scientists). Honored young researcher, 9th Iranian Seminar of Pharmaceutical Sciences, Tabriz, 2004 (Offered by Iranian Association of Pharmaceutical Scientists). The best book translation (Adverse effects of herbal drugs vol. 1 and 2), Research week festival, Mashhad, 2004 (Offered by MUMS) 1 Three awards from Iranian Nanotechnology Initiative for supervision of two Pharm.D. thesis. The best book translation (Pharmaceutics, vol. 1), Research week festival, Mashhad, 2006 (Offered by MUMS) Honored lecturer, MOALEM week festival, Mashhad, 2007 (Offered by MUMS) The best book translation (Pharmaceutics, vol. 2), Research week festival, Tehran, 2007 (Offered by University of Tehran) The best book translation (Pharmaceutics, vol. 2), Research week festival, Mashhad, 2007 (Offered by MUMS) The best presentation in ICRC 2011, Mashhad, 2011 (Offered by Iranian Controlled Release Society). The best book translation (Nonprescription Drug Therapy), Research week festival, Mashhad, 2011 (Offered by MUMS) Memberships Member of “MUMS Scholarship Council” Member of “Nanotechnology Research Center”, Mashhad University of Medical Sciences Member of “Pharmaceutical Research Center”, Mashhad University of Medical Sciences Member of “Controlled Release Society of Iran” Editorial member of Asian Pacific Journal of Tropical Medicine (2009-2011) Reviewer of Drug Development and Industrial Pharmacy journal Reviewer of Journal of Drug Targeting Reviewer of Journal of Microencapsulation Reviewer of Journal of the Taiwan Institute of Chemical Engineers Reviewer of Iranian Journal of Pharmaceutical Research Reviewer of Iranian Journal of Basic Medical Sciences Reviewer of DARU journal Workshops: "Preparation of recombinant antibodies (originated from camels and mice immunoglobulins)". School of Medical Sciences, Tarbiat Modarres University, Tehran, 2004 (3 days). "1st Iran-Russia joint seminar & workshops on nanotechnology". Tehran, Iran, 2005 (2 days). "Web browsing and Reference manager". Chancelor for Research, Mashhad University of Medical Sciences, Mashhad, 2006 (3 days). "Regional workshop on ethics in medical research" Chancelor for Research, Mashhad University of Medical Sciences, Mashhad, 2006 (2 days). "Special codes in ethics in medical research" Chancelor for Research, Ministry of health, Tehran, 2006 (2 days). "MCQ design" Mashhad University of Medical Sciences, Mashhad, 2006 (1 days). 2 " Research in education" Mashhad University of Medical Sciences, Mashhad, 2006 (2 days). "Nanotechnology in drug delivery" Tehran University of Medical Sciences, Tehran, 2007 (1 days). "SPSS " Mashhad University of Medical Sciences, Mashhad, 2007 (2 days). "Advanced Word " Mashhad University of Medical Sciences, Mashhad, 2009 (2 days). "EndNote" Mashhad University of Medical Sciences, Mashhad, 2009 (2 days). "Advanced Outlook" Mashhad University of Medical Sciences, Mashhad, 2009 (1 days). "Advanced Powerpoint " Mashhad University of Medical Sciences, Mashhad, 2009 (1 days). "Scholarship in Education" Mashhad University of Medical Sciences, Mashhad, 2010 (1 days). Publishes and presentations Books 1. Tafaghodi, M., Amiri, R., Hosseinzadeh, H., 1998. Adverse Effects of Herbal Drugs. Volume 1, MUMS Press, Mashhad. (Translation), 4th print 2007. 2. Tafaghodi, M., Hosseinzadeh, H., 2002. Adverse Effects of Herbal Drugs. Volume 2, MUMS Press, Mashhad. (Translation), 3rd print, 2007. 3. Hosseinzadeh, H., Tafaghodi, M., 2006. Adverse Effects of Herbal Drugs. Volume 3, MUMS Press, Mashhad. (Translation). 4. Afrasiabi, H., Tafaghodi, M., Sajadi, S.A., Sadeghi, F., 2006. Pharmacetics, the science of dosage form design. Volume 1, MUMS Press, Mashhad. (Translation, 2nd print, 2009). 5. Afrasiabi, H., Tafaghodi, M., Sajadi, S.A., Sadeghi, F., Fazly, B.S., 2007. Pharmacetics, the science of dosage form design. Volume 2. (Translation), 2nd print, 2010. 6. Imenshahidi, M., Moallem, S.A., Tafaghodi, M., Rezaei, Ramin, Firouzi, Zohreh, 2011. Nonprescription Drug Therapy. MUMS press, Mashhad. (Translation) Papers 1- Diwan, M., Tafaghodi, M., Samuel, J., 2002. Enhancement of immune responses by codelivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres. Journal of Controlled Release, 85, 247-262 2- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R., 2002. Drug delivery from nasal route. Razi,, 155, 32-42. 3- Tafaghodi, M., Hasanzadeh, M., Rahimizadeh, M., 2003. Isolation and identification of Hyoscyamus insanus alkaloids. Iranian journal of Medicinal Plants, 2(7), 29-36. 3 4- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R.., 2004. Utilization of particulate and immuno-modulating adjuvants for enhancement of immune responses against tumors antigenic markers. Iranian Journal of Basic Medical Sciences, 6(4), 336-345. 5- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R., Zakavi, S.R., Momen-nejad, M., 2004. Evaluation of the clearance characteristics of various microspheres in the human nose by gamma-scintigraphy. International Journal of Pharmaceutics, 280, 125-135. 6- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R.., 2004. Mucosal immunization. Razi, 175, 17-24. 7- Tafaghodi, M., Jaafari, M.R.., Sajadi Tabasi, S.A., 2004. Adjuvants. Razi, 174, 34-45. 8- Sajadi Tabasi, S.A., Tafaghodi, M., Jaafari, M.R., 2004. Dextran microspheres encapsulated with tetanus toxoid as a delivery system for nasal immunization: in vitro and in vivo characterization. Iranian Journal of Basic Medical Sciences, 7(2), 88-98. 9- Jaafari, M.R., Tafaghodi, M., Sajadi Tabasi, S.A., 2005. Evaluation of the clearance characteristics of liposomes in the human nose by gamma-scintigraphy. Iranian Journal of Pharmaceutical Research, 4(1), 3-11. 10- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R., 2006. Formulation and characterization and release studies of alginate microsphere encapsulated with tetanus toxoid. Journal of Biomaterials Science. Polymer Edition., 17(8), 909-924. 11- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R., 2006. Induction of systemic and mucosal immune responses by intranasal administration of alginate microspheres encapsulated with tetanus toxoid and CpG-ODN. International Journal of Pharmaceutics, 319, 37-43. 12- Tafaghodi, M., Jaafari, M.R., Sajadi Tabasi, S.A., 2006. Nasal immunization studies by liposomes encapsulated with tetanus toxoid and CpG-ODN. European Journal of Pharmaceutics and Biopharmaceutics, 64, 138-145. 13- Tafaghodi, M., Jaafari, M.R., Nikouzadeh, A. 2007. Evaluation of systemic and mucosal immune responses following the nasal immunization by various sizes of liposomes encapsulated with tetanus toxoid. Iranian Journal of Basic Medical Sciences, 9, 4(32), 307315. 14- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R., 2007. Nasal immunization study by PLGA nanospheres encapsulated with tetanus toxoid and CpG-ODN. Iranian Journal of Pharmaceutical Research, 6(3), 151-158. 15- Ghiasi, Z., Sajadi Tabasi, S.A., Tafaghodi, M., 2007. Preparation and In Vitro Characterization of Alginate Microspheres Encapsulated with Autoclaved Leishmania major (ALM) and CpG –ODN. Iranian Journal of Basic Medical Sciences, 10(2), 90-98. 4 16- Tafaghodi, M., Sajadi Tabasi, S.A., Payan, M., 2007. Alginate microspheres as delivery system and adjuvant for autoclaved Leishmania major (ALM) and Quillaja saponin (QS) - Preparation and characterization. Iranian Journal of Pharmaceutical Sciences, 3(2), 61-68. 17- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R., 2008. Nasal immunization studies by cationic, fusogenic and cationic-fusogenic liposomes encapsulated with tetanus toxoid. Current Drug Delivery, 5, 108-113. 18- Tafaghodi, M., Sajadi Tabasi, S.A., Kharazizadeh, M., 2008. Preparation and characterization of PLGA nanospheres encapsulated with autoclaved Leishmania major (ALM) and Quillaja saponin. Saudi Pharmaceutical Journal, 16(1), 43-49. 19- Sajadi Tabasi, S.A., Tafaghodi, M., Jaafari, M.R., 2008. Induction of high antitoxin titers against tetanus toxoid in rabbits by intranasal immunization with dextran microspheres. International Journal of Pharmaceutics, 360, 12-17. 20- Tafaghodi, M., Hadizadeh, F., Farahmand, F., 2008. Comparison of spectrophotometry and spectroflourimetry methods in determination of encapsulation efficiencies of TT in microspheres and liposomes, Pharmaceutical Sciences, summer, 53-59. 21- Tafaghodi, M., Sajadi Tabasi, S.A., Amiri, N., 2008. PLGA nanospheres loaded with Autoclaved Leishmania Major (ALM) and CpG-ODN: Preparation and in vitro characterization. Iranian Journal of basic medical Sciences, 11(2), 112-119. 22- Deldar, K., Nazemi, E., Balali Mood, M., Emami, S.A., Mohammadpour, A.H., Tafaghodi, M., Afshari, R., 2008. Effect of Coriandrum sativum L. extract on lead excretion in 3-7 year old children, Journal of Birjand University of Medical Sciences, 15, 11-19. 23- Amin, M.R., Jaafari, M.R., Tafaghodi, M., 2009. Nasal immunization studies in rabbits by anionic and chitosan coated liposomes encapsulated with tetanus toxoid as a model antigen. Colloids and Surfaces B. Biointerfaces, 74, 225-229. 24- Khadivzadeh, T., Samadi, S., Emami, A., Tafaghodi, M., Sanjar Moosavi, N., Behnam, H.R., 2010. The Effect of Hypericum Perforatum on the Wound Healing and Scar of Cesarean. Journal of Alternative and Complementary Medicine, 16(1), 113-117. 25- Tafaghodi, M., Rastegar, S., 2010. Preparation and in vivo study of dry powder microspheres for nasal immunization. Journal of Drug Targeting, 18(3), 235-242. 26- Emami, S.A., Fakhrjafary, M., Tafaghodi, M., Hassanzadeh, M.K., 2010. Chemical Composition and Antioxidant Activities of the Essential Oils of Different Parts of Cupressus arizonica Greene. Journal of Essential Oil Research, 22, 193-199. 27- Tafaghodi, M., Jaafari, M.R., Eskandari, M., Khamesipour, A., 2010. Immunization against leishmaniasis by PLGA nanospheres loaded with an experimental Autoclaved Leishmania major (ALM) and Quillaja saponins. Tropical Biomedicine, 27, 639-650. 28- Mohaghegh, M., Tafaghodi, M., 2011. Dextran microspheres could enhance immune responses against PLGA nanospheres encapsulated with tetanus toxoid and Quillaja 5 saponins after nasal immunization in rabbit. Pharmaceutical Development and Technology, 16, 36-43. 29- Alipour, S., Montaseri, H., Tafaghodi, M., 2010. Preparation and characterization of paclitaxel loaded alginate microparticles for pulmonary delivery. Colloids and Surfaces B. Biointerfaces, 81, 521-529. 30- Tafaghodi, M., Jaafari, M.R., Samiei, A., Soroush, D., Khamesipour, A., 2011. Immunization against leishmaniasis by PLGA nanospheres encapsulated with Autoclaved Leishmania major (ALM) and CpG-ODN. Parasitology Research, 108, 1265-1273. 31- Tafaghodi, M., Jaafari, M.R., Eskandari, M., Khamesipour, A., 2011. Alginate microspheres encapsulated with Autoclaved Leishmania major (ALM) and CpG-ODN induced partial protection and enhanced immune response against murine model of leishmaniasis. Experimental Parasitology, 129, 107-114. 32- Maleki, M., Karimi, G., Tafaghodi, M., Raftari, S., Nahidi, Y., 2012. Comparison of Intralesional 2% zinc sulfate and Glucantime injection in treatment of acute cutaneous Leishmaniasis. Indian Journal of Dermatology, 57, 118-122. 33- Tafaghodi, M., Eskandari, M., 2012. The mucosal adjuvant potential of cross-linked dextran microspheres (CDM) as dry powder. Iranian Journal of Basic Medical Sciences, 15, 873-879. 34- Moghadam Aryaee, F., Tafaghodi, M., 2012. Mucosal adjuvant potential of Quillaja saponins and cross-linked dextran microspheres, co-administered with liposomes encapsulated with tetanus toxoid. Iranian Journal of Pharmaceutical Research (In Press). 35- Khodaverdi, E., Tafaghodi, M., Ganji, F., Abnoos, K., Naghizadeh, H., 2011. In vitro insulin release from thermosensitive chitosan hydrogel. AAPS PharmSciTech (In Press). 36- Tafaghodi, M., Saluja, V., Kersten, G.F.A., Kraan, H., Slütter, B., Amorij, J.-P., Jiskoot W., 2012. Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: impact of formulation on physicochemical and immunological characteristics. Vaccine (In Press). 37. Montaseri, H., Alipour, S., Tafaghodi, M., 2011. Paclitaxel loaded large porous particles for pulmonary delivery: in vitro evaluation. (Submitted to Colloids and Surfaces B, Biointerfaces). 38- Tafaghodi, M., Jaafari, M.R., Eskandari, M., Khamesipour, A., 2011. Immunization against leishmaniasis by Alginate microspheres loaded with Autoclaved Leishmania major (ALM) and Quillaja saponins (Submitted to Iranian Journal of Parasitology). 39- Zarifpour, M., Hadizadeh, F., Iman, M., Tafaghodi, M., 2011. Preparation and characterization of trimethylchitosan (TMC) nanospheres encapsulated with tetanus toxoid (Submitted to Pharmaceutical Sciences). 6 Conference presentations 1- Tafaghodi, M. Shokouhi Nejad, H., 1995. Evaluation of different methods of determination of poor soluble substances. Proceeding of the 2nd congress of Iranian pharmacy students, Mashhad, Iran. 2- Moghimipour E., Dehghan G. and Tafaghodi M., 1998. The study of HPMC concentrations on physical properties of coated tablets. Proceeding of the 6th Iranian Congress of Pharmaceutical Sciences, Tehran, Iran. 3- Tafaghodi M., Rahimizadeh M., Hassanzadeh M., 2000. Isolation and characterization of alkaloids of Hyoscyamus insanus. Proceeding of the 7th Iranian Congress of Pharmaceutical Sciences, Mashhad, Iran. 4- Tafaghodi, M., Jaafari, M.R., Sajadi Tabasi, S.A., 2000. Formulation and characterization of liposomes containing tetanus toxoid. Proceeding of the 7th Iranian Congress of Pharmaceutical Sciences, Mashhad, Iran. 5- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R., 2002. Preparation and characterization of alginate microspheres encapsulated with tetanus toxoid for nasal delivery. Proceeding of the 8th Iranian Congress of Pharmaceutical Sciences, Shiraz, Iran. 6- Tafaghodi, M., Diwan, M., Samuel, J., Jaafari, M.R., Sajadi Tabasi, S.A., 2002. Increasing the immune responses by co-delivery of tetanus toxoid and CpG ODN encapsulated in PLGA nanospheres. Proceeding of the 8th Iranian Congress of Pharmaceutical Sciences, Shiraz, Iran. 7- Tafaghodi, M., Zakavi, S.R., Sajadi Tabasi, S.A., Jaafari, M.R., Momen Nejad, H., 2002. Gamma-Scintigraphy as a novel method to study the distribution and clearance rate of different mucoadhesive nasal delivery systems. Proceeding of the 6th Annual Meeting of Nuclear Medicine, Mashhad, Iran. 8- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R.., 2003. Nasal immunization using alginate microspheres encapsulated with tetanus toxoid (TT). Proceeding of the 1st Congress of New Drug Delivery Systems, Tehran, Iran. 9- Sajadi Tabasi, S.A., Tafaghodi, M., Jaafari, M.R.., 2003. Nasal immunization using cross-linked dextran microspheres encapsulated with tetanus toxoid (TT). Proceeding of the 1st Congress of New Drug Delivery Systems, Tehran, Iran. 10- Tafaghodi, M., Jaafari, M.R.., Sajadi Tabasi, S.A., 2003. Nasal immunization using neutral, cationic, fusogenic and cationic-fusogenic liposomes encapsulated with tetanus toxoid (TT). Proceeding of the 1st Congress of New Drug Delivery Systems, Tehran, Iran. 11- Tafaghodi, M., Samuel, J., Diwan, M., Sajadi, S.A., Jaafari, M.R., 2003. Utilization of particulate and immunomodulating adjuvants for enhancement of immune response against tumors antigenic markers. Proceeding of the 3rd Congress of National Biotechnology, Mashhad, Iran. 7 12- Tafaghodi, M., Sajadi Tabasi, S.A., Jaafari, M.R.., 2006. Nasal immunization studies by alginate and cross-linked dextran microspheres and PLGA nanospheres encapsulated with tetanus toxoid (TT). Proceeding of the 10th Iranian Congress of Pharmaceutical Sciences, Tehran, Iran. 13- Tafaghodi, M., Sajadi Tabasi, S.A., Kharazizadeh, M., 2007. Preparation and characterization of PLGA nonospheres encapsulated with autoclaved Leishmania major (ALM) and saponin adjuvant. Proceeding of the 3rd Congress of New Drug Delivery Systems, Tehran, Iran. 14- Tafaghodi, M., Hadizadeh, H., Farahmand, F., 2007. Determination of encapsulation efficiency of fluorescent tetanus toxoid in microsphere and Liposome drug delivery systems by spectrofluorimetery method. Proceeding of the 3rd Congress of New Drug Delivery Systems, Tehran, Iran. 15- Tafaghodi, M., Jaafari, M.R., Amin, M.R., 2007. Nasal Immunization Studies in Rabbits by Anionic and Chitosan Coated Liposomes Encapsulated with Tetanus Toxoid as a Model Antigen. Proceeding of the 1st Vaccine Congress, Amsterdam, Netherland. 16- Tafaghodi, M., Jaafari, M.R., Sajadi Tabasi, S.A., 2008. Preparation, characterization and immunization studies with PLGA nonospheres encapsulated with autoclaved Leishmania major (ALM) and saponin adjuvant. Proceeding of the 11th Iranian Congress of Pharmaceutical Sciences, Kerman, Iran. 17- Tafaghodi, M., 2009. Nanoparticulate drug delivery systems as vaccine adjuvant and delivery system. Proceeding of the Nanodrugs, nano-biotechnology, nano-biosensors and nano-materials in medical sciences. Mashhad, Iran. 18- Tafaghodi, M., Jaafari, M.R., Sajadi, S.A., Khamesipour, A., Amiri, N., 2009. Immunization against leishmaniasis by PLGA nanospheres encapsulated with autoclaved Leishmania major (ALM) and CpG-ODN. ICRC 2009, Zanjan, Iran. 19- Tafaghodi, M., Mohaghegh, M., 2009. Dextran microspheres could enhance immune responses against PLGA nanospheres encapsulated with tetanus toxoid and Quillaja saponins after nasal immunization in rabbit. ICRC 2009, Zanjan, Iran. 20- Tafaghodi, M., Jaafari, M.R., Sajadi Tabasi, S.A., 2009. Induction of immune responses against leishmaniasis by alginate microspheres encapsulated with autoclaved Leishmania major (ALM) antigen and CpG-ODN. Proceeding of the 3rd Modern vaccine adjuvant and delivery systems, Vienna, Austeria. 21- Tafaghodi, M., Jiskoot, W., Saluja, V., 2011. Hepatitis B surface antigen (HBsAg) nanoparticles coated with chitosan and trimethyl chitosan (TMC): impact of formulation on physicochemical and immunological characteristics. Research projects and grants 1- Nasal immunization using various sizes of liposomes encapsulated with tetanus toxoid in rabbit (approved by MUMS, 2003) (Finished 2006) 8 2- Determination of encapsulation efficiency of florescent tetanus toxoid in microsphere and liposome drug delivery systems by spectrofluorimetery method (approved by MUMS, 2003) (Finished 2006) 3- Evaluation of immunization potential of alginate and PLGA microspheres encapsulated with Autoclaved Leishmania major (ALM) and Quillaja saponin (QS) and CpG-ODN in murine model (approved by MUMS, 2004) (Finished 2008) 4- Nasal immunization using negatively charged liposomes encapsulated with tetanus toxoid and coated with chitosan (approved by MUMS, 2006) (Finished 2007) 5- Nasal immunization using multiple nanosphere and microsphere drug delivery system encapsulated with antigens and adjuvants- tetanus toxoid as model antigen (approved by MUMS, 2006) 6- Formulation, Characterization, In-vitro and In-vivo Evaluation of paclitaxel loaded microspheres for pulmonary delivery (approved by MUMS, 2006) 7- Pre-clinical studies in rabbits for finding the most optimum nanosphere drug delivery system and adjuvant for formulation of influenza mucosal (nasal) vaccine using inactivated whole virus (approved by INSF, 1386 (50%)- by MUMS, 1387 (50%)) 8- Synthesis of N-trimethylchitosan chloride and preparation and size analysis of its microspheres (Approved by MUMS, 2006) (Finished 2008) 9- Nasal immunization studies by anionic liposomes coated with trimethylchitosan chloride (TMC) encapsulated with tetanus toxoid (Approved by MUMS, 2008) 10- Preparation & characterization of temperature sensitive microsphere & nanosphere of PLGA-PEG-PLGA loaded by insulin and evaluation of impact of particle size on in-vitro release profiles and in-vivo efficiency (Approved by MUMS, 2009) 11- Preparation of insulin dry powder inhaler (DPI) for pulmonary delivery and in vitro and in vivo evaluation of particles (Approved by MUMS, 2009) 12- Preparation and characterization of porous PLGA microspheres loaded with gentamicin and evaluation of tissue distribution of drug after pulmonary administration in rat (Approved by MUMS, 2009) 13- In vitro study of PEGylation and size effects on interaction of PLGA nanospheres with macrophage cells (Approved by MUMS, 2009) 14- Evaluation of immunoadjuvant potential of trimethylchitosan nanospheres encapsulated with tetanus toxoid after nasal immunization in rabbits (Approved by MUMS, 2009) 15- Rabbit nasal immunization against influenza by PLGA nanospheres encapsulated with inactivated virus (Approved by MUMS, 2009) 16- The effect of liposome containing gentamicin and oleic acid on methicillin-resistant Staphylococcus aureus (Approved by MUMS, 2011) 17- Preparation, characterization, and evaluation of induced immune response by chitosan and trimethyl chitosan nanoparticles containing whole Leishmania lysate (WLL) and soluble Leishmania antigen (SLA) in a mouse model (Approved by MUMS, 2012) 9 Last update: July/2012 10