Curriculum Vitae
Bijan Malaekeh Nikouei (Pharm.D, Ph.D.)
Assistant Professor in Pharmaceutics,
School of Pharmacy and Pharmaceutical Research Center,
Mashhad University of Medical Sciences (MUMS),
Mashhad, Iran
P.O. Box: 91775-1365
Phone: +98 511 8823255-6 or +98 511 7112611
E-mail: malaekehb@mums.ac.ir
Gender: male
Date of birth: June 24th, 1976
Place of birth: Mashhad, Iran
Residence: Mashhad, Iran
Marital status: Married
Number of Children: 2
Education:
- Research fellowship (6 month) in University of Queensland, Australia
(2005)
- Ph.D. in Pharmaceutics from School of Pharmacy, Mashhad University
of Medical Sciences (2001-2006)
- Pharm.D. from School of Pharmacy, Tabriz University of Medical
Sciences (1994 -1999)
Workshops:
- "Electronic databases", Mashhad University of Medical Sciences,
Mashhad, 2007, (1 day).
- "Teaching Methods", Mashhad University of Medical Sciences,
Mashhad, 2007, (2 days).
- "Education Planning", Mashhad University of Medical Sciences,
Mashhad, 2007, (2 days).
- "MCQ", Mashhad University of Medical Sciences, Mashhad, 2007, (1
day).
- "SPSS", Mashhad University of Medical Sciences, Mashhad, 2007, (3
days).
- "EndNote", Mashhad University of Medical Sciences, Mashhad,
2007, (1 day).
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- "Peer Review", Mashhad University of Medical Sciences, Mashhad,
2007, (1 day).
- "Nanostructures", Kish University, Kish Island, 2006, (3 days).
- "Application of Nanotechnology in Drug Delivery", Tehran
University of Medical Sciences, Tehran, 2007, (1 day).
- "Biomedical writing", Mashhad University of Medical Sciences,
Mashhad, 2008, (3 days).
- "Medical Journalism", Mashhad University of Medical Sciences,
Mashhad, 2008, (1 day).
Research interests:
Particulate drug delivery systems including Microspheres and
Nanospheres, Liposomes, Solid lipid nanoparticles (lipospheres),
Nanobiotechnology, Designing of non-viral vectors, Targeted drug
delivery, Peptide and protein formulation, Instrumental analysis
Current research projects:
1) Preparation and evaluation of nano-sized galactosylated lipoplexes
effect on transfection efficiency
2) Preparation and characterization of microspheres encapsulated with
triamcinolone for intravitreal administration
3) Preparation and in vitro and in vivo evaluation of liposomal
Avastin (Anti-VEGF IgG) for intravitreal administration:
comparison with soluble form
4) Preparation, characterization and transfection evaluation of peptide
coupled lipoplexes as non-viral vectors for gene therapy
5) Formulation of foluorometholone ophthalmic solution using
cyclodextrins
6) Synthesis of PEGylated fatty acids as carrier for targeted solid lipid
nanoparticles (lipospheres)
7) Preparation and characterization of topical liposomes encapsulated
with total extract and fractions of Platycladus orientalis
8) Preparation, characterization and evaluation of tumoricidal effects
of solid lipid nanoparticles (lipospheres) containing docetaxel in
tumor-bearing mice
9) Preparation, characterization and evaluation of transfection efficiency of
nanoliposomes modified with polyethylenimine
10) Preparation and characterization of liposomes encapsulated with
clindamycin and tretinoin
11) Study of cytotoxic and apoptogenic properties of Crocin, Safranal
and their nanoliposomes in various cancer cell lines
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12) Preparation and evaluation of transfection efficiency of cationic
liposome-PEI-plasmid nanocomplexes
13) Preparation and study of phase solubility of inclusion complexes of
beclomethasone with cyclodextrins to enhance water solubility of
the drug for inhalation
14) Evaluation of diclofenac release from its molecularly imprinted
polymer in aqueous and organic solvents
Publications:
A) Published:
1) Hasanzadeh D., Malaekeh-Nikouei B., 1997, Quantitative analysis
of H2-blockers by FT-IR: comparison with HPLC method,
Pharmaceutical Sciences (Journal of Tabriz Faculty of Pharmacy),
3, 25-32. (Persian)
2) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., 2004,
Preparation and characterization of biodegradable microspheres
encapsulated with cyclosporine A using different grades of PLGA,
Iranian Journal of Basic Medical Sciences, 7, 4, 240-249 (Persian).
3) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., Samiee A.,
2005, Preparation of fusogenic liposomes encapsulated with
cyclosporine A and evaluation of its immunosuppressive effects on
human T-cells, Pharmaceutical Sciences (Journal of Tabriz Faculty
of Pharmacy), 2, 1-9 (Persian).
4) Jaafari M. R., Malaekeh-Nikouei B., Nasirli H., Hosseinzadeh H.,
2005, Formulation of topical liposomes encapsulated with
triamcinolone and comparison of their anti-inflammatory effects
with available conventional topical ointment in mice, Iranian
Journal of Basic Medical Sciences, 8, 3, 195-201 (English).
5) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., Davies N. M.,
2005, Preparation and characterization of PLGA microspheres
loaded by cyclosporine-cyclodextrin complex, Iranian Journal of
Pharmaceutical Sciences, 1, 4, 195-201 (English).
6) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., 2006, The
effect of different grades of PLGA on characteristics of
microspheres encapsulated with cyclosporine A, Current Drug
Delivery, 3, 4, 343-349 (English).
7) Malaekeh-Nikouei B., 2006, Liposomes as novel drug delivery
system, Razi, 211, 59-64 (Persian).
8) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., Davies N. M.,
2006, The effect of complexation on characteristics and drug
release of PLGA microspheres loaded by cyclosporine3
cyclodextrin complex, Journal of Drug Delivery Science and
Technology, 16(5), 345-350 (English).
9) Malaekeh-Nikouei B., Nassirli H., Davies N. M., 2007,
Enhancement of cyclosporine aqueous solubility using α- and
hydroxypropyl β-cyclodextrin mixtures, Journal of Inclusion
Phenomena and Macrocyclic Chemistry, 59 (3-4), 245-250
(English).
10) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., 2007,
Preparation, characterization and mucoadhesive evaluation of
chitosan coated liposomes containing cyclosporine A, Saudi
Pharmaceutical Journal, 15, 3-4, 176-182 (English).
11) Malaekeh-Nikouei B., Abrishami M., Zarei S., 2008, Liposomal
formulation of bevasizuamb for intravitreal administration: increased
half-life, decreased side effects, Iranian Journal of Medical
Hypotheses and Ideas, 2:4, (Persian).
12) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., 2008,
Preparation, characterization and mucoadhesive properties of
chitosan coated microspheres encapsulated with cyclosporine A,
Drug Development and Industrial Pharmacy, 34, 5, 492-498
(English).
13) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., Samiee A.,
2008, The Enhancement of Immunosuppressive Effects of
Cyclosporine A on Human T-Cells Using Fusogenic Liposomes,
Colloids and Surfaces B:Biointerfaces, 67, 238-244 (English).
14) Abrishami M., Zarei-Ghanavati S., Soroush D., Rouhbakhsh M.,
Jaafari M. R., Malaekeh-Nikouei B., 2009, Preparation,
characterization and in vivo evaluation of nanoliposomes
encapsulated bevacizuamb for Intravitreal administration, Retina, 29,
5, 699-703 (English).
B) In press:
1) Malaekeh-Nikouei B., Davies N. M., 2009, Double loading of
cyclosporine A in liposomes using cyclodextrin complexes, PDA
Journal of Pharmaceutical Science and Technology, March-April,
(English).
2) Malaekeh-Nikouei B., et al., 2009, Preparation, characterization
and transfection efficiency of nanoliposomes modified with
oligoamines as gene carrier, Nanomedicine, (English).
3) Malaekeh-Nikouei B., et al., 2009, The influence of size, lipid
composition and bilayer Tm on the transfection efficiency of
nanolipoplexes, Colloids and Surfaces B:Biointerfaces, (English).
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4) Malaekeh-Nikouei B., Sajadi Tabassi S.A., Ashari H.,
Gholamzadeh A., Evaluation the effect of cyclodextrin
complexation on aqueous solubility of fluorometholone to achieve
ophthalmic solution, Journal of Inclusion Phenomena and
Macrocyclic Chemistry, (English).
Presentations:
1) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., Afshin Samiei,
The effect of phospholipid type and size on immunosuppressive
activities of liposomes encapsulated with cyclosporine A, 11th
Liposome Research Days Conference, July 2008, Yokohama, Japan.
2) Malaekeh-Nikouei B., Ramezani M., Malaekeh-Nikouei M.,
Kazemi Oskuee R., Preparation, characterization and transfection
efficiency of nanoliposomes modified with oligoamines as gene
carrier, 11th Iranian Pharmaceutical Sciences Conference, Aug
2008, Kerman, Iran.
3) Gholamzadeh A., Ashari H., Malaekeh-Nikouei B., Sajadi Tabassi
S.A., Evaluation of sulphobutylether β-cyclodextrin and
hydroxypropyl γ-cyclodextrin complexation on aqueous solubility of
fluorometholone, 11th
Iranian Pharmaceutical
Sciences
Conference, Aug 2008, Kerman, Iran.
4) Shahsavand S., Mehri S., Moallem S.A., Mosavi S.H., MalaekehNikouei B., Assessment of cytotoxic and apoptogenic properties of
crocin and its nanoliposomes in various cancer cell lines, 11th
Iranian Pharmaceutical Sciences Conference, Aug 2008, Kerman,
Iran.
5) Mehri S., Shahsavand S., Moallem S.A., Mosavi S.H., MalaekehNikouei B., Assessment of cytotoxic and apoptogenic properties of
safranal and its nanoliposomes in various cancer cell lines, 11th
Iranian Pharmaceutical Sciences Conference, Aug 2008, Kerman,
Iran.
6) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., Preparation,
characterization and mucoadhesive evaluation of chitosan coated
liposomes containing cyclosporine A, The Third Iranian Conference
of Novel Drug Delivery Systems, June 2007, Tehran, Iran.
7) Sajadi S. A., Malaekeh-Nikouei B., Jaafari M. R., Davies N. M.,
The effect of complexation on characteristics of and drug release
from PLGA microspheres loaded by cyclosporine-cyclodextrin
complex, 33rd Annual Meeting and Exposition of the Controlled
Release Society, July 2006, Vienna, Austria.
8) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., Preparation and
characterization of chitosan coated microspheres encapsulated with
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cyclosporine A, 10th Iranian Pharmaceutical Sciences Conference,
Aug 2006, Tehran, Iran.
9) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., Samiei A., The
enhancement of immunosuppressive effects of cyclosporine A on
human T-cells using fusogenic liposomes, 10th Iranian
Pharmaceutical Sciences Conference, Aug 2006, Tehran, Iran.
10)
Sajadi S. A., Malaekeh-Nikouei B., Jaafari M. R.,
Preparation and characterization of biodegradable microspheres
encapsulated with Cyclosporine A using different grades of PLGA, 1ST
Pharmaceutical Sciences Fair & Exhibition, June 2005, Nice, France.
11)
Malaekeh-Nikouei B., et al., Formulation of topical
liposomes encapsulated with triamcinolone and comparison of their
anti-inflammatory effects with available conventional topical
ointment in mice, 9th Seminar of Pharmaceutical Sciences, Aug
2004, Tabriz, Iran.
12)
Malaekeh-Nikouei B., et al., Preparation and
characterization of biodegradable microsphere encapsulated with
Cyclosporine A using different grades of PLGA, 9th Seminar of
Pharmaceutical Sciences, Aug 2004, Tabriz, Iran.
13)
Malaekeh-Nikouei B., et al., Comparison of different
physicochemical analysis methods of H2-blockers, 1st Seminar of
Pharmaceutical Methodology, Sep 2001, Mashhad, Iran.
14)
Hasanzadeh D., Malaekeh-Nikouei B., Development of
quantitative FT-IR analysis of H2-blockers: comparison with the
HPLC methodology, Proc. 3rd World Meeting APV/APGI, April
2000, Berlin, Germany.
Book:
1) Stuart S., Modern Infrared Spectroscopy, 2002, Tabriz University
of Medical Sciences (Translation to Persian).
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