RESPIRE REspiratory Science Promoted by International Research Exchanges Cover Page SEVENTH FRAMEWORK PROGRAMME FP7 Marie Curie Actions – People Co-funding of Regional, National and International Programmes Grant agreement for: COFUND Annex I - “Description of Work” Project acronym: RESPIRE Project full title: REspiratory Science Promoted by International Research Exchanges Grant agreement no.: 229571 Date of preparation of Annex I (latest version): 7th August 2008 Date of approval of Annex I by Commission: Page 1 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges PART A A.1: List of Beneficiary and host organisations (where applicable) Beneficiary/ Host organisations Number * Beneficiary/ Host organisation name Beneficiary /Host organisation short name Country Date enter project** Date exit project** 1 European Respiratory Society ERS Switzerland Month 1 Month 36 2 * Please use n° 1 for beneficiary and the following numbers, where applicable, for pre-identified host organisations actively involved in the programme ** Normally insert “month 1 (start of project)” and “month n (end of project)” A.2: Project Summary Free Keywords: Health sciences, Medical sciences, Chronic diseases, Emergent diseases, respiratory diseases and medicine, asthma, COPD, TB Abstract: The European Respiratory Society (ERS), the main scientific society in the respiratory field in Europe, promotes research into respiratory diseases in children or adults, including asthma, cystic fibrosis, COPD, lung cancer, and sleep-related respiratory disease. Since 1998, the ERS has operated a successful programme of trans-national exchange of researchers in pneumology and respiratory science. The aim of the current RESPIRE proposal, is to expand this programme and stimulate post-doctoral research opportunities in the respiratory field within Europe. RESPIRE will fund 1-year research fellowships to enable holders of a PhD (or others with equivalent research experience) to conduct research in a European country other than their own. The specific objective of RESPIRE is to triple the number of fellowships from the current 2 post-doctoral fellowships per year to a total of 18 fellowships over 3 years. Candidates from outside Europe will be eligible, but only host institutions based in Europe will participate in the programme. There will be no discrimination according to age, gender, ethnic origin, religious or political beliefs. In line with the existing evaluation process of the ERS, RESPIRE will ensure that all applications undergo an impartial and rigorous peerreview evaluation by recognised (but anonymous) international experts. Then, through a procedure free of conflicts of interest, the scientific committee of the ERS will select the fellows based on scientific merits and transparent criteria. RESPIRE will be evaluated using quantifiable scientific output measures, as well as indicators of human achievements. RESPIRE will not only boost the careers of the fellowship recipients, it will also promote the European Research Area, by creating the platform needed to enhance and maintain scientific networks, and retaining promising researchers in Europe. This will in turn be an important step towards conquering some of the most disabling diseases in Europe. Page 2 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges PART B Introduction Founded in 1990, the European Respiratory Society (ERS, www.ersnet.org) is an international scientific society, composed of nearly 9000 members in over 100 countries who represent pneumologists and other medical disciplines (paediatricians, intensive care, oncology, thoracic surgeons etc); scientists and allied health professionals in the field of respiratory medicine across Europe and globally. It is the pre-eminent medical society in Europe in its field and represents the main forum for scientific exchange and continuing education for medical doctors and scientists engaged in lung science in Europe and beyond. The ERS mission is to alleviate suffering from respiratory disease and to promote lung health through research, knowledge sharing, medical and public education and advocacy. The ERS promotes and supports respiratory science through the dissemination and exchange of knowledge at the Annual Congress, the Lung Science Conference and research seminars, and via scientific publications and the production of guidelines. The ERS also directly supports science and research through task forces, research awards, and particularly through research fellowships. The ERS through the ERS School supports an extensive education programme with educational symposia at the annual congress and external courses. The ERS fellowship programme was started in 1998 and has over the years grown to be a highly-esteemed programme supporting the best young researchers in respiratory science in Europe. Overall, every year, the ERS supports 10–13 long-term fellowships of 12-months (30–50 applications received) and around 15 short-term fellowships of 3 months (40–60 applications received). With the aid of the proposed RESPIRE programme, the ERS will now extend its fellowship programme, and highlight and stimulate post-doctoral career opportunities in the respiratory research area in Europe. B 1 Selection process for the fellows under the programme 1.1 Transparency of the selection process for the fellows under the programme Describe the efforts made to promote the programme and its calls, both nationally and abroad, in order to reach the target audience. The target for the ERS long-term post-doctoral research fellowship programme, proposed in this application by the acronym RESPIRE, consists of experienced researchers in the respiratory field. Applicants will be accepted only if they are in the possession of a doctoral degree, or have the equivalent of 4 years full-time research experience. The RESPIRE programme offers fellowships of 1 year with the possibility of renewal at the end of the period. The programme is open to both Europeans and non-Europeans, but host-institutions are always located in Europe. The RESPIRE fellowships described in this application are part of a larger fellowship programme offered by the ERS, which covers both long-term and shortterm fellowships aimed at both training and research, and includes also early-stage experienced researchers. For details on the complete ERS fellowship programme, see enclosure 1, “ERS Fellowships 2008” which provides the rules and guidelines for applicants. Since the ERS is an international organisation, the promotion efforts of the programme are both across Europe and worldwide. Different means of promotion will be used in order to reach the target audience, and these will include both internal advertisement activities within the ERS, as well as promotional activities aimed at reaching a wider audience. Specific efforts will be made to prevent circulation to be restricted to ERS members and associated activities, Page 3 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges individuals or institutions. Notably, Community websites such as e.g. Cordis and Euraxess will be used to disseminate actions related to the RESPIRE programme, and calls for fellowships will be made through the support of these websites. The support of these Community websites will enable higher access and visibility to the RESPIRE programme at a European level, targeting in this way a larger audience and supporting exchange with the focused host institutions for this programme, which are located in Europe. With regard to the specific ERS promotional activities, the following actions regularly take place, aiming at reaching both ERS members and non-ERS members:: About four months before the application deadline, each of the 9000 ERS members receives printed information, including a poster advertising the ERS fellowship programme for the coming year, enclosure 2. Members are encouraged to display the posters in their hospitals and research units. In addition, the ERS sends targeted email alerts to its 35,000 database contacts advertising the fellowships with targeted reminders before each deadline, enclosure 3. The ERS fellowship programme is also promoted via the website of the ERS and can be accessed via: www.ersnet.org/fellowships. Before each deadline the programme is the main topic of the ERS website homepage. The fellowship programme is also advertised, using updated versions of the advert presented in enclosure 2, upon request by the ERS Scientific Activities Department in the main ERS scientific publications: The European Respiratory Journal (ERJ). The ERJ is a scientific journal, publishing original peer-reviewed research articles. It is issued monthly and is ranked third internationally in respiratory medicine according to its ISI impact factor of 5.076 for 2006. The ERJ reaches all the 9000 members and most university hospitals and similar institutions at national level that have specialist departments in respiratory medicine. Breathe the ERS official educational journal and provides high-quality up-todate material for pneumologists, general practitioners, and allied health professionals especially those in clinical practice. Breathe includes CME accredited articles. It offers expert advice on special topics. The circulation of Breathe is over 15,000 copies and is distributed to ERS members as well as non-ERS members. Promotion for the fellowship programme occurs at a bi-monthly basis in the ERS Newsletter, an electronic publication which is sent out by e-mail to all members of the ERS, but which is also freely available to all, and can be downloaded directly from the ERS website, see: http://dev.ersnet.org/109-latest-issue.htm. A standard, constant feature in the ERS Newsletter is the specific section on “ERS Fellowships” which both advertises and promotes the ERS fellowship programme, see enclosure 4. Every issue also has a specific section called “ERS Fellowships” and provides an opportunity for one or two fellows to describe how they have benefited from the ERS fellowship scheme, see enclosure 5 - articles of the ERS Newsletter, May 2007 and January 2008. The ERS also summarises the results of the fellowship applications in its Newsletter. A key activity of the ERS is to organise an Annual Congress in respiratory medicine. It has grown to become the world's largest gathering in respiratory medicine with over 17,000 worldwide delegates attending. The ERS Annual Congress is used to actively promote the fellowship programme in the following ways: Page 4 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges - Promotional articles on the fellowships are included in the Congress publications (Advance and Final Programme), see enclosure 6, including mention of the candidates awarded the previous year. A dedicated scientific session during the ERS congress, where ERS fellows can present their results and share experiences, the “ERS Fellows” Lunch session. Fellowships are promoted at the ERS Stand at the ERS Annual Congress, which is always situated at a prominent position at the congress centre and is held at different European locations every year, see http://dev.ersnet.org/415general-information.htm The ERS Fellowships are also promoted during the numerous other seminars, courses, workshops and conferences organised by the ERS or at many other national and international meetings where the ERS is represented and/or has a stand, thereby also targeting nonmembers. Finally all ERS officers are encouraged to actively promote the Fellowships through their country or community. All ERS officers also receive a brochure called “Scientific and Educational Activities – an overview of the opportunities and services offered to Assembly and Group officers”, which also provides information on the ERS Fellowships, see enclosure 7. The promotional posters that are sent to the 9000 ERS members will be publicly displayed in the university hospitals and/or laboratories and institutes, and will thus reach out beyond the membership of the Society and promoted at local, national level. In addition to promotional material on ERS fellowships sent to all 9000 ERS members, the ERS also manages a central database consisting of more than 35 000 contacts most of whom are non-members. These individuals may have had some former contact with the ERS and interest in respiratory medicine, and will also receive targeted email alerts with regard to imminent fellowship deadlines, see enclosure 2. Typically these may be ERS congress delegates, representatives of other specialties or sub-specialities (e.g. cardiologists; allergologists; paediatricians etc); registered attendees to ERS research seminars/external courses; investigators and/or other representatives of R&D-based pharmaceutical companies etc. The contact database also includes former members of the ERS. Non-members of the ERS will be informed about the fellowships directly through their attendance at the ERS Annual Congress, which attracts some 17,000 delegates, many of whom are non-Europeans, or belong to other specialities, and so not necessarily professional members of the ERS. Information about the ERS and its range of scientific and educational activities are regularly promoted at other major international conferences in the field of respiratory medicine, and where the ERS is represented, notably annual events of the American Thoracic Society (ATS) and American College of Chest Physicians (ACCP). Describe how applicants are informed about the evaluation and the selection process, in particular about the evaluation criteria used to grade applications. Applicants are informed about the evaluation and selection process on the ERS website and the documents that can be downloaded from there. The rules and guidance document “ERS Fellowships 2008” see section 3.6 “Selection”, enclosure 1 which describes in detail the selection and evaluation procedure that applies for the ERS fellowships. Page 5 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges In brief, candidates are informed that selection focuses on the scientific excellence of the researcher/clinician and the proposed work as described by the candidates in their Project Description, which forms an essential part of the application - see section 4.4, enclosure 1. Section 3.6 clearly explains that the selection is made on the basis of the overall average score of the scientific expert evaluation of the candidate application by the three external expert reviewers. Section 3.6 also lists the individual six evaluation criteria upon which the experts are asked to grade the application, as well as the applicable grades and their respective meanings. Section 3.6, enclosure 1, emphasises that experts of the highest international standing in their respective fields carry out this evaluation task and that their assessments are normally confidential and not divulged outside the ERS, but that upon specific request from the candidates themselves, the “anonymised” reviewers’ comments and marks can be made available to them. Candidates are also informed that no distinction will be made between candidates on the basis of gender, ethnic origin, sexual orientation and religious or political beliefs. Finally they are notified that the decisions are final and appeals are not considered. Describe how and at what stage applicants are informed about the evaluation results. The awarded applicants are informed through an official letter from the ERS Chair of the Scientific Committee, which is sent both by regular post and electronically via e-mail. Those, whose proposals could not be awarded, receive a letter via e-mail only. All applicants receive the final reply at the same time (normally 4 months after the application deadline) regardless of whether the application was positively or negatively evaluated. 1.2 Composition and organisation of selection committees Describe your criteria for the selection and balance of experts on the selection committee(s) The organisation of the selection process of the fellows is the responsibility of the ERS Scientific Committee, which is composed mainly of the Heads of the 11 Scientific Assemblies and the Chair of the Committee, see enclosure 8. The Assembly Heads are elected by the members for a 3-year mandate, and they are generally recognised leaders in their respective disciplines. The Scientific Assemblies are composed of members with a similar interest in specific areas within the broad field of respiratory medicine. Their purpose is to provide a scientific forum. The final decision on the fellowships is taken by the ERS Executive Committee. After the application deadline is closed, the applications are assigned by the Chair of the Scientific Committee to the most relevant Scientific Assembly Heads, depending on the topic of the application. Each Assembly Head is then responsible for assigning each application for external review to three experts of the highest international standing in their respective field. The assessments by the experts will then be collected by the Assembly Heads and brought forward to the Scientific Committee. Based on the assessments, the Scientific Committee prepares a recommendation which is put forward to the Executive Committee who takes the final decision about which applicants are rewarded. The three experts are selected by the Assembly Heads on the basis of them having an in-depth knowledge about the research topic proposed by the fellowship applicant. Criteria for selecting the experts include relevant recent publications in the field, related research Page 6 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges activities, authorship of textbooks, or educational activities in the topic. Invited experts are both European and non-European, and they may be ERS members as well as non-ERS members. The choice of experts is made by the Assembly Head. The ERS encourages the Assembly Heads to make a balanced choice in terms of gender, country origin and experience, but the emphasis should be on the scientific expertise and knowledge. The proposed experts must not be from the applicants’ home or host institution, and must not have a potential or actual conflict of interest. Members of the Scientific Committee (who prepare the recommendations for accepted fellows) and Executive Committee (who take the final decision) are elected and thus selected by means of the nomination and voting procedures as stipulated in the ERS Constitution and its Bylaws. A regular rotation of experts on the Scientific Committee is ensured following the election results and the regular entry of new Assembly Heads. Describe how these criteria for selecting experts follow the "Code of Conduct for the Recruitment of Researchers"12(e.g. is the gender balance adequate, are different disciplines and sectors (private and public) represented, are there experts from other countries)? The experts are selected based on their merits in their respective scientific fields. Criteria for selecting the experts include relevant recent publications on the topic, related research activities, authorship of text books, or educational activities in the field. It is irrelevant whether they are European or non-European, and both ERS and non-ERS members are invited. The choice of experts is made by the Assembly Head. The ERS encourages the Assembly Heads to make a balanced choice in terms of gender, country of origin and experience but the emphasis should be on the scientific expertise and knowledge. The proposed experts must not be from the applicants’ home or host institution, and may not have a potential or actual conflict of interest. Explain how your selection progress is organised (e.g. how many experts read a proposal, who takes the final decision about the selection/rejection of a proposal, etc.) General procedure The Chair of the ERS Scientific Committee presents the final list of candidates one by one to the ERS Executive Committee and recommends the Committee to approve these selected candidates for the award of an ERS fellowship. The Executive Committee has the power to raise objections to one or more of the selected candidates if the selection procedure was contested. This, however, is an unlikely scenario as most of the discussion has already taken place in the Scientific Committee which is composed of Assembly Heads who also are members of the Executive Committee. The Executive Committee of the ERS makes the final decision on the selection of researchers to be awarded the ERS RESPIRE fellowship. The ERS Scientific Committee is involved in the preparatory work, and puts forward the recommendation to the Executive Committee for final decision. The recommendation on individual candidates is in turn based upon the average overall score and comments of the experts. Detailed description of selection procedure 1) The applications received by the ERS Secretariat (Scientific Department) are allotted individual fellowship numbers. The applications are briefly reviewed by the Chair of the Page 7 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges Scientific Committee who assigns it to the relevant Assembly Heads depending on the research area chosen by the applicant and in the absence of conflicts of interest. 2) The completed on-line application, see enclosure 9, received by the ERS Secretariat will thus contain the following: (1) Fellowship sought including expected start and finishing dates; (2) Applicant personal details (3) Home supervisor details (4) Host supervisor details (5) Professional qualifications and experience of the applicant. In addition the following documents need to be up-loaded online: 1x short CV (max 1 page), 1x publication list; 1x project description (max 4 pages); 3) The candidate is requested to download and complete the following documents from the online application link and send it by return fax or email to the ERS Scientific Activities Department: 1x home supervisor release, enclosure 10; 1x host acceptance form, enclosure 11; and 2x reference forms, enclosure 12, from independent professional colleagues familiar with the applicants’ work, neither of whom belong to the home laboratory or host institution. 4) The application, which can be viewed via a specific link online, is sent together with an accompanying letter signed by the Scientific Committee Chair to the Assembly Head asking him/her to enter the names of three different, suitable experts of the highest international ranking for each application. The letter also informs the Assembly Head that the proposed experts should not include any person from the applicants’ home institution or host institution. 5) Each application is then sent to the three proposed experts together with a letter from the ERS informing them that the Assembly Head has proposed them as a potential reviewer. The letter asks them if they accept the invitation to evaluate the application for a fellowship, and asks them to use the online reviewing system to grade and evaluate the application within a 15 day deadline. The letter also says that in case they cannot act as an expert, they should inform the ERS Scientific Department without delay, so that the Assembly Head can nominate another potential reviewer. 6) The ERS Scientific Department receives the completed “Research Fellowship Review Form” from the three experts, see enclosure 13. Each application is compiled with the three reviews and then sent to the appropriate Assembly Head. 7) Prior to the meeting of the ERS Scientific Committee, all the documents are prepared by the ERS Scientific Activities Department containing each full application and the “anonymised” expert evaluations. The ERS Scientific Dept. will prepare the work of the Scientific Committee by listing all applicants, their individual average scores of the three expert grades, and the average overall score for each applicant. The summary list will thus present the highest average overall scorers at the top and the lowest scorers at the bottom of the list, see enclosure 14. These are up-loaded on the ERS intra-net and are to be printed out by all the Assembly Heads prior to the meeting. The applications with the lowest scores e.g. average score of < 3.5 are normally discussed very briefly and are usually not considered further. Applications with high scores undergo an iterative evaluation process. Page 8 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges 8) At the start of the Scientific Committee meeting, and before each application is discussed, the Chair will announce the total budget available for fellowships, and thus the final number of applicants that can be awarded a fellowship. 9) The applications together with the experts’ evaluation are presented one by one by the Assembly Head according to the pre-ranked order, see enclosure 14, with the recommendation of the Assembly Head to the Scientific Committee. The general principle is that the Assembly Head is to follow the final recommendation of the experts. 10) Further discussions on each fellowship application take place right after the summary presentation made by the Assembly Head at the meeting of the Scientific Committee. There may be additional questions as well as valuable insights about the research topic/ the applicant etc coming from other Assembly Heads. After the discussion, the Scientific Chair proceeds to state what the general consensus of the Scientific Committee should be, and proposes a final decision (which is minuted) to recommend or to refuse to grant an ERS fellowship. Sometimes there are several applications which are equally good. These are put on “hold” pending the outcome of the discussions of the other applicants. Those applications will then be discussed again in an iterative process, to see which of those candidates would benefit most from an ERS fellowship since it may not be possible to fund all applications. 11) At the Executive Committee meeting, which is held the day after that of the Scientific Committee, the Scientific Committee Chair will present the final list of candidates as officially agreed by the Scientific Committee that have been chosen to be awarded an ERS fellowship. The final decision is then made by the Executive Committee who thus formally approves the recommendation of the Scientific Committee. How do you handle potential and actual conflicts of interest of the experts? External experts will be asked to review an application only if there is no potential or actual conflict of interest. Those with conflicts of interests will not be asked. In the case the Assembly Head was not aware of a conflict of interest, the expert is asked to indicate any possible conflict upon receiving the invitation to review the application. In cases when a member of the Scientific Committee has a potential or actual conflict of interest with an applicant, the home or host-institution, he/she leaves the room during the discussion and is not allowed to vote when the final decision about the applicant is made. 1.3 Criteria and method of judging merit Describe the criteria for the selection of fellows. Explain how they allow the identification of the scientific capability of the applicants. Do they take into account diverse knowledge and qualifications (e.g. scientific/practical/management experience, trans-national mobility, intersectoral mobility, etc.) Experts are asked to grade the applications according to five criteria using a scale 1-5 and using only whole numbers, as is indicated in the ERS Fellowship Expert Reviewer Form, enclosure 13. The following grades are given: Page 9 of 33 RESPIRE 5 4 3 2 1 REspiratory Science Promoted by International Research Exchanges Excellent - Should be funded with highest priority Very Good - Should be funded Good - Could be funded with lesser priority Average - Probably not funded Poor - Should not be funded In order to identify the scientific capability of the applicant, several categories of the application are graded. Grading these different categories will allow consideration of the diverse knowledge and qualifications of the fellow, career stage, scientific achievements and management experience (applicants are asked to submit a CV, as well as a list of publications) and relevance of the topic. The fellowships awarded by the ERS are typically European transnational, but ERS also funds fellows from outside EU-27 to undertake a fellowship in Europe. Moreover, the ERS applies the “WHO Europe” definition of Europe, which includes a total of 53 countries. Specifically, each of the following criteria will be given a grade: Relevance of the topic Methodology (including ethical considerations)/hypothesis/originality Likelihood of project completion Adequacy of the host-institution for this project Added value of travelling Achievable results (which takes into account where the applicant comes from and hence the degree of development of research in the applicant’s home environment) The average grade is then calculated, and will be used in the comparison with other candidates and the final evaluation. Explain how your ethical rules align with the Commission's ethical principles for FP7. The ERS acknowledges the importance of adhering to the Commission’s ethical principles for FP7. Therefore, several measures will be implemented in the RESPIRE programme to ensure adherence to these principles. The expert reviewers will be requested to comment on ethical issues in each application. Moreover, a member of the ERS’ own Ethical Committee will review all successful applications before start of each fellowship, in order to make sure that research to be carried out is in line with the ethical principles of FP7. Main ethics issues that must be addressed in each accepted fellowship project are: informed consent, human embryonic stem cells, privacy and data protection, use of human biological samples and data, research on animals, research in developing countries, and dual use. Furthermore, in line with national and international legislation each research programme in an accepted fellowship application must be approved by an ethical review board at the host-institution, before it is commenced. A copy of the approval by the ethical review board will be requested by the ERS, and must be submitted at the latest at the time of the interim report, which is 6 months after the start of the fellowship. A signed statement from the host institution will be requested before start of the fellowship and before making the first payment. The statement must include the following points: 1) Certification that there is an ethical review board for research at the host institution 2) The research conducted at the laboratory of the host institution is in compliance with local, national and international legislation and guidelines on research in humans and/or animals, 3) All necessary steps will be undertaken to ensure that the specific research project for which Page 10 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges the application is made, will be in compliance with these legislation and guidelines, including the FP7 Ethical Principles, as specified below, 4) Documentation of ethical approval of the proposed research will be provided to the ERS as part of the interim report.. Specifically, the following fields of research will not be financed in the RESPIRE programme: Research activity aiming at human cloning for reproductive purposes Research activity intended to modify the genetic heritage of human beings which could make such changes heritable Research activities intended to create human embryos solely for the purpose of research or for the purpose of stem cell procurement, including by means of somatic cell nuclear transfer. If relevant, describe how you treat ethical issues that might appear in an applicant's research. As indicated above, reviewers will be asked to include ethical considerations in their assessments; these will also be considered by the Scientific Committee, with help from a representative of the ERS Ethical Committee, before granting a fellowship. In case of doubt, the fellowship will not be granted. Documentation of approval of the research by the host's institution ethical review board will have to be provided with the interim report. Failure to provide this will result in termination of the grant. Any evidence or suspicion of breaches of ethical conduct and/or scientific integrity during (or after) the fellowship will result in a rapid and thorough assessment by the ERS Ethical Committee. If necessary, this may result in termination of the fellowship and/or other appropriate actions towards the host institution and its authorities. Explain how the merit of returnees from a career break is valued, if relevant. All relevant experiences (such as for instance management or practical experiences) will be included in the evaluation of the candidates. The ERS has amended its Fellowship Rules following a decision of the Scientific Committee at its recent meeting of 7 Feb. 2008, to remove the age limit for fellowship applicants. This will ensure that for instance those who have been on a parental leave or other career-break will not be put at a disadvantage. The same applies to those who have received time-consuming specialist training. B.2 Management of the programme 2.1 Appointment conditions of selected fellows Describe how you assure that appropriate technical conditions are provided for the selected fellows in terms of office/lab space, access to appropriate equipment and material etc. The host institution must ensure that the candidate will have access to the appropriate technical equipment, material, office and lab space at the host-institution. This is an important aspect of the selection procedure, confirmed by completion of the “Host Acceptance Form”, enclosure 11. In the fellowship application there should be a detailed description on how the partnership between the host and fellow would take full advantage of the facilities, resources and materials available. The adequacy of the host will be evaluated by the expert reviewer, and only hosts offering appropriate technical conditions will be accepted. Detailed guidelines Page 11 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges for the host supervisor are currently being drafted by the ERS Secretariat with the objective to ensure the fulfilment of both practical and scientific aspects which are relevant in the beginning (housing, safety), during the completion (regular meetings, evaluations) and at the end/ during the follow-up of the fellowship. The host will also be required before start of the project, to confirm in writing to the ERS that they provide for the necessary facilities to carry out the research, as well as that lab and office space will be available to the fellow during his/her stay. Describe the employment conditions provided to the fellows, including statutory working practices, social security coverage and social benefits (contribution to pension funds, health and accident insurance, parental leave etc.) When an application has been approved by the ERS Scientific Committee, the ERS will inform both the fellow and his/her home institution of the decision. In addition, in order to make sure that the fellow will be appropriately taken care of, the ERS will inform the host institution and ask the promotor to confirm in writing that they are prepared to receive the fellow. The written confirmation by the host should include a starting date of the fellowship, and a confirmation of the host institution’s responsibilities which include availability of lab and office space; ability to conduct the projected research; and verification that health & safety issues are taken care of. The host will also be asked to assist the fellow in housing and other practical issues (e.g. he/she will be directed to the university’s housing department). Moreover, a signed ethics statement must be submitted by the host at this stage (see also above, section 1.3). An important aspect of this written confirmation will be that the host will be requested to assign named persons as scientific and administrative mentors for the fellow. The first one being responsible for the scientific part of the fellow’s project, whereas the second mentor will be responsible for coaching the fellow in all matters related to visa requirements, registration with the university, opening a bank account, housing, finding appropriate schools for the fellow’s children, etc. The ERS will at the start of the fellowship write to the fellow to ensure that all practical matters have been taken care of, and that the fellow has optimal starting conditions. If there are any problems, the fellow has the possibility to report these to the ERS, who in such cases will contact the host in order to try to solve the problems. An interim (or mid-term) report will be requested from the fellow (and signed by the host supervisor) at 6 months after start of the project. This report will include scientific progress, as well as administrative and other issues. At this time also a copy of approval of the research project by the local ethical review board needs to be submitted. An end-of-project report including the same topics as the interim report will have to be submitted at the end of the fellowship. The ERS will check published output and other outcomes after two years and after five years after completion of the project. The ERS provides grants directly to the individual, and half of the grant is paid out in advance onto the fellow’s bank account in the host country upon his/her arrival. The remaining sum of the grant is paid out by the ERS after six months, following receipt (and approval by the ERS) of the interim report from the fellow. Grants are funded according to the personal and professional circumstances of the fellow and the host country. The ERS subsistence rates are based on those published by the European Molecular Biology Organisation (EMBO) www.embo.org, See section 3.5, enclosure 1, ERS Fellowship Rules, and the updated EMBO rates in enclosure 15. Page 12 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges ERS fellows are encouraged to engage in teaching, discussion and similar activities of the institution they visit. They may not, however, engage in any paid or salaried activities during the course of their fellowships. The size of the grants is such that it allows for the fellows to arrange for necessary insurances and pension schemes for themselves and their families. Each fellow’s individual situation is different, depending on both the home and host countries’ provision of statutory working practices, social security coverage and social benefits, and whether or not the fellow is employed or not by his/her home institution during the stay abroad. The ERS has therefore chosen to pay the grant to each fellow in two separate payments, which then can be used by the fellow in the best way to cover individual needs. Please note that there is no requirement in the ERS Fellowship Rules stating that the fellow must be employed by the host institution. Having a link with their home institutions, e.g. through previous employment, scholarship, studentship or other, is a sufficiently qualifying application criterion. Explain how these conditions align with regional, national or sectoral conditions, as specified in the "European Charter for Researchers and The Code of Conduct for the Recruitment of Researchers"? Since the ERS is a non-governmental international organisation whose awards are not automatically endowed with any particular tax privileges, it is the sole responsibility of the recipient of an award to pay any tax which may be levied upon him/her by the relevant national authority. The ERS is neither a funder nor an employer according to the definitions in the “European Charter for Researchers” but seeks to promote research by facilitating research and training exchanges on a trans-national level by providing a grant according to the personal and professional circumstances of the fellow and the host country. The ERS subsistence rates are based on those published by the EMBO, and thus is adjusted according to host country, age of the fellow and the number of dependents. 2.2 Quality of the programme management Describe the management plan of the programme and the resources; include a chart giving an overview over the deliverables and milestones of the programme and its implementation. The ERS RESPIRE fellowship programme will include two calls, and aims to approve and complete 18 one-year post-doctoral fellowships in the 36-month period. See figure 1 for a tentative distribution of the fellowships during this period, as well as the programmes deliverables (D) and milestones (M). The distribution of the fellowships over the three-year period allows for some flexiblity, but the end-result will be 18 successfully accomplished fellowships. The programme will start with the opening of the first call (D1), which will be followed by a four-month expert review process, to be concluded with the decision of the successful applications (D2). A number of 8 fellows will be rewarded as a result of the first call. Upon notification of the results to the fellows and hosts (D3), the hosts will be required to confirm the acceptance of the fellow as well as to submit a statement that FP7 ethical rules will be followed in the fellow’s project. The awarded fellows will then start preparing their stay at the host institution. The start dates of the fellowships will be flexible and at the discretion of the fellows, but should generally be according to the dates indicated in their applications. Page 13 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges It is estimated that as a result of the first call at least 5 post-doctoral fellows will be able to start their projects within one year of start of the programme (M1). The remaining 3 rewarded fellows will start their projects in the second year of the programme (M2). Mid-term (interim) reports (D4 and D6) and end-of-project reports (D5 and D7) will be a requirement to fulfil by all fellows at 6 months after start of the project, and within one month after the fellowships have been concluded. The mid-term report will include a copy of the ethical approval by the local ethical review board at the host institution. The second call (D8) will be opened 12 months after the first call and will aim to lead to the selection of 10 candidates. After completion of the review (D9) and notification to the fellows and hosts (D10), it is estimated that at least 3 fellowships will be started during the second year (M3). This makes a total of 6 started fellowships in the second year, including the 3 fellowships that start in the second year as a result of the first call. The remaining 7 fellowships will be completed before the programme is finished at the end of the third year (M4). Months 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 D1: First call open D2: Review of applications D3: Notification to fellows and host M1: 5 fellowships year 1 (first call) D4: Mid-term report D5: End-of-project report M2: 3 fellowships year 2 (first call) D6: Mid-term report D7: End-of-project report D8: Second call open D9: Review of applications D10: Notification to fellows and host M3: 3 fellowships year 2 (second call) D11: Mid-term report D12: End-of-project report M4: 7 fellowships year 3 (second call) D13: Mid-term report D14: End-of-project report Figure 1. Overview of deliverables and milestones of the RESPIRE programme. Once the fellow has completed the fellowship he/she is expected to submit within one month an end-of-project report as well as a completed ERS Fellowship questionnaire to the ERS, see enclosure 16. Upon approval of this report the fellow will be eligible to become a member of the Association of ERS Fellows and will also receive an “ERS Fellows Certificate” upon successful completion of the fellowship. The day-to-day management of the fellowship programme is handled by two dedicated and experienced full-time staff based at the ERS Scientific Department in Lausanne. These are the (i) Head of the Scientific Activities Department and (ii) the Scientific Activities Coordinator. The Finance Department is only involved when a request for transfer of payment to the account of the awarded fellow is received from the Scientific Activities Coordinator. Page 14 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges Strategic decisions and recommendations for change of the fellowship programme are the responsibility of the Scientific Committee, with specific guidance provided by the elected Chair of the ERS Scientific Committee and the nominated ERS Research Director, see figure 2. Scientific Knowledge and Execution and implementation Expertise of RESPIRE fellowship ERS ERS Scientific Scientific Committee Committee Recommendation Recommendation Experts Experts Review Review Ethical Ethical aspects aspects ERS ERS Executive Executive Committee Committee Decision Decision Execution and implementation Scientific Knowledge and Expertise of RESPIRE fellowship ERS Scientific ERS Scientific Committee Chair, Committee Chair, ERS Research ERS Research Director, ERS Director, ERS Executive Director Executive Director ERS Activities Dept. ERS Scientific Scientific Activities Dept. ERS Department ERS Finance Finance Department Figure 2. Management plan of the ERS RESPIRE Fellowship Programme. Figure 2. Management plan of the ERS RESPIRE Fellowship Programme. Since the initiation of the ERS fellowship programme in 1998, the staff at the ERS Scientific Activities Department has built up valuable experience in managing and running the programme efficiently. The staff at the ERS Scientific Dept is responsible for advertising the fellowships and announcing the deadlines, collecting all applications and distributing them to the Scientific Committee Chair who in turn will assign the applications to the Assembly Heads. The Scientific Department will also receive electronically all the incoming expert reviews and distribute them to the responsible Assembly Heads. Once the final decisions have been taken at the Scientific and Executive Committee, the Secretariat will implement the decisions e.g. will be responsible for sending the signed letters to the applicants informing them about the result of their applications. The Scientific Department also collaborates with staff of the Finance Department, who is responsible for paying out the grants into the fellows’ bank accounts. At the termination of each fellowship period, the Scientific Department sends out a questionnaire which serves as an end-of-project report from the fellows. If several organisations propose a joint programme, please describe the responsibilities of each partner organisation. Page 15 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges Not applicable.Describe any review process that is associated with the programme, and which may have already been carried out for existing programmes. At the end of the programme the fellows are asked to complete and submit within one month an ERS Fellowship questionnaire in 22 parts and also to write a short end-of-project report (section 23), which is sent to them via email by the Scientific Dept, see enclosure 16. In the questionnaire the fellows are asked to include details on their satisfaction with the programme and their host regarding both practical and scientific matters. In addition, the host is also asked to provide comments on their experience about the completed fellowship, see section 24, enclosure 16. The results of these questionnaires are evaluated by the ERS and used to review the programme. Overall, the fellows respond very positively on the programme. However, comments were also made and as a result of this review process, some of the rules have been amended during the past two years. Among other things, it was decided at the Scientific Committee meeting in Feb. 2008 to remove the age limit for application (which used to be 40). Moreover, it has also been made possible to submit a renewal application in order to extend a 1-year fellowship to 2 years, and ERS fellowships may be used as an extension of previous support from other sources. These new rules will also be applicable to the RESPIRE fellowships. Give an overview over the qualification and experience of the senior staff responsible for the management of the programme. The ERS fellowship programme has been running since 1998 and the staff at the ERS office in Lausanne has acquired an extensive experience in managing this programme. The Head of the ERS Scientific Activities Department is the dedicated senior staff responsible for managing the programme. The Head of Scientific Activities Dept, Ms Carine Pannetier, holds a masters degree in biochemistry and has worked for 3 years at the ERS office in Lausanne. She is also responsible for coordinating the Scientific Programme of the ERS Annual Congress, and for managing and preparing the work, agenda and minutes of the meetings of the ERS Scientific Committee. Other senior ERS staff and officers who are responsible in managing the programme are the Executive Director, the Chair of the Scientific Committee and the Research Director. The ERS Executive Director, Jean-Luc Eiselé, PhD, was appointed in his current position in September 2007, based upon his strong merits in administration as well as respiratory science. Mr Eiselé previously held the position as Deputy Executive Manager of the ERS and was also the Scientific and Education Department Manager. He has been leading ERS activities in the educational and scientific arena since 1999 and has extensive knowledge of the current ERS Fellowship Programme. Mr Eiselé has been an active researcher in biochemistry in Switzerland and France 1984-2007, holding a position at the Pasteur Institute in Paris, initially as a recipient of a long-term EMBO fellowship. This opportunity gave him an in depth knowledge of all aspects of fellowship programmes from recipient to management. The ERS Scientific Committee Chair is currently Professor Benoit Nemery. He has been elected for a period of three years, starting in September 2006. Professor Benoit Nemery is Head of the Lung Toxicology Research Unit, within the Laboratory of Pneumology, at the Faculty of Medicine, and is also Chair of the Dept of Public Health of the Katholieke Universiteit, Leuven. He has vast experience within the ERS. He has served as both the Assembly Secretary and Head in the Occupation and Epidemiology Assembly. His main scientific interests focus on the mechanisms of pulmonary toxicity caused by various agents. Page 16 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges As a clinician, he treats patients with various occupational and environmental diseases, including occupational asthma and asbestos-related disorders. Professor Sven-Erik Dahlén is the newly-appointed ERS Research Director, whose home institute is the Karolinska Institutet, Stockholm, where he is Head of a research unit of approximately 25 basic and clinical scientists. He is also the Director of the Centre for Allergy Research at this institute, a network organisation within the Karolinska Institutet that attempts to stimulate trans-disciplinary research by supporting some core facilities, postdoctoral positions and project grants for collaborative research. On a European level Prof. Dahlén has been involved in several EU projects and is the coordinator of the BIOAIR project (FP5) and Team Leader for the EU network of Excellence GA2LEN (FP6). He possesses extensive experience of evaluating quality in science in various reviewing and granting bodies. Both the Scientific Committee Chair and the Research Director are strongly involved in developing and strengthening the ERS future research activities in the field of respiratory medicine at the European level, but also to further strengthen the existing ERS fellowship programme making it more competitive and attracting a larger part of the respiratory researchactive community. Give an overview of the estimated programme budget including the requested co-funding contribution (use table as appropriate). Demonstrate that you will use the Community contribution in line with the objectives and scope of the COFUND action as described in the Work programme. In the RESPIRE programme the Community contribution will be used to increase the number of trans-national post-doctoral fellowships awarded by the programme. The number of experienced researchers holding a doctoral degree that were awarded a long-term ERS fellowship have so far been low, as the focus of the programme has been on less-experienced researchers. Among the 13 long-term fellows awarded in 2007, 2 were in possession of a PhD, although there were also a number of clinicians with several years of experience in clinical research. The ERS recognises the importance of stimulating the post-doctoral research opportunities in Europe and has therefore decided to expand the long-term fellowship programme for experienced researchers (the proposed RESPIRE programme), while at the same time maintaining the other components of its fellowship programme (including shortterm and training fellowships) at an undiminished level. The present application for COFUND will be for a period of 36 months. See figure 3 for the estimated increase of the RESPIRE programme budget. The budget is also explained in detail below. Page 17 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges 300 CoFund contribution 250 Budget (kEUR) ERS contribution 200 150 100 50 0 Year prior Year 1 Year 2 Year 3 Figure 3. The RESPIRE programme budget. The estimated RESPIRE budget for the first year of the programme: Budget in the year prior to the CoFund application: 80.000 EUR (2 fellowships) Proposed increase of the programme: 121.000 EUR (3 fellowships) Total cost of the programme: 201.000 EUR (5 fellowships) CoFund contribution (40% of total): 80.000 EUR Own contribution: 121.000 EUR Please note: all costs including 10% overhead and 5% management costs This will be subsequently increased to a total of 6 fellowships for the second year and 7 fellowships for the third year, as follows: The estimated RESPIRE budget for the second year of the programme: Budget in the first year of the programme: 201.000 EUR (5 fellowships) Proposed increase of the programme in the second year: 41.000 EUR (1 fellowship) Total cost of the programme: 242.000 EUR (6 fellowships) CoFund contribution (40% of total): 97.000 EUR Own contribution: 145,000 EUR Please note: all costs including 10% overhead and 5% management costs The estimated RESPIRE budget for the third year of the programme: Budget in the second year of the programme: 242.000 EUR (6 fellowships) Proposed increase of the programme in the third year: 41.000 EUR (1 fellowships) Total cost of the programme: 282.000 EUR (7 fellowships) CoFund contribution (40% of total): 113.000 EUR Own contribution: 169.000 EUR Please note: all costs including 10% overhead and 5% management costs Please note: the current budget estimations do not take into account yearly increase due to inflation. 2.3 Client-friendliness towards applicant researchers Describe your application documentation, with particular view to accessibility and usability. Page 18 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges The fellowship application procedure is processed wholly on-line in English language via the ERS website, and is accessible to everyone throughout the year at the following link: http://www.ersnet.org/fellowship08/login/default.aspx?type=1. First time users need to create a username and password, see enclosure 17. Once the personal account is created, applicants can enter and re-enter the account as they choose. They can change the information as long as they do not press the "submit" button. Once the submit button is pressed, amendments to their application can only be made if he or she directly contacts the ERS Secretariat. The “ERS Fellowship Rules”, enclosure 1, and other necessary information can also be accessed via the application website. In addition to the information entered directly via the on-line system, a number of documents need to be uploaded onto the system. Other documents require the applicant to first download templates, have them completed, and then return them in a separate email or via fax to the Secretariat. This is clearly explained via the on-line system. The additional documents include a curriculum vitae, a publication list, a project description of maximum 4 pages, 2 reference forms, 1 home supervisor release form and 1 host acceptance form, see enclosures 9, 10, 11& 12. This system has been in use for a number of years and has proven to be user-friendly and well-functioning. In the event where an applicant may have failed to upload certain documents, they will be contacted directly via email by the ERS Secretariat (Scientific Department) and given the opportunity to submit them afterwards. Do you offer support to applicants? If so, describe the individual functions (e.g. help-desk, FAQ's, Quality assurance)? The ERS Scientific Department in Lausanne provides a help-desk function by handling any direct queries by phone or e-mail that may come from applicants and that relate to any questions or problems to the application procedure. The on-line application indicates that any queries on the application process should be sent to the general email provided. Specific eligibility-related queries from applicants that may imply a change in rules or other principle discussions, are collected and added as an agenda item to be discussed in the up-coming ERS Scientific Committee meeting at the same time when the applications are discussed. The decision of the committee may then result in a change of the ERS Fellowship Rules. The applicant is then informed that the query will be discussed at the subsequent meeting, and that he/she will be informed of the final decision. Moreover, as mentioned earlier, the applicant will have a chance to complete his/her application since the Secretariat staff actively request the on-line system company to notify them in the event that the online application is incomplete with missing documentation. Thus, there is no exclusion of applicants in the submission phase and the Scientific Department actively ensures that all supporting documents of applicants are in place, and notifies those candidates where there are missing supporting documents, encouraging them to complete their application. Describe the information to applicants about the expected time to receive evaluation results and to start fellowships The applicants are informed in the guidelines for the application that they will receive the evaluation results four months after the application deadline. Those applicants that are awarded a fellowship may then start the fellowship according to the start-date that they themselves propose, provided that this date allows sufficient time to solve practical issues such as passport, visa, housing etc. Page 19 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges Illustrate the feed-back given to the applicants about the evaluation results (e.g. are the reasons for rejection explained in detail? Are strengths and weaknesses of the proposal mentioned?). Those who did not get awarded the fellowship receive an e-mail with a letter in which they are briefly informed of the fact that unfortunately the budget for the fellowship programme allows only an average of 20-35% of applications to be accepted, and that therefore it was not possible to fund their proposals. The exact percentage varies from year to year and depends on the number of applications received and budget available for funding. As already mentioned under section 1.1 the reasons for the rejection are not normally explained in detail in the letter to the applicant, although these may be made available to the candidate upon request. In that case the candidate would get a transcript of the “anonymised” three expert reviewer individual scores and comments, including a clear statement of the reasons for declining the proposal. 2.4 Administrative capacity to implement the programme Show that your organisation/institution has the necessary infrastructure to carry out the administrative tasks of the proposed fellowship programme As explained in section 2.2, the ERS fellowship programme has been running since 1998, and the ERS Scientific Activities Department, has acquired extensive experience to manage the programme efficiently. The staff at the ERS Scientific Dept. is responsible for advertising the fellowships and announcing the deadline, collecting all applications and distributing them to the Scientific Committee Chair who in turn will assign the applications to the Assembly Heads. They collect all expert reviews and distribute them to the responsible Assembly Heads. Once the final decisions have been made, the staff is responsible for sending the letters to the applicants informing them about the result. The Scientific Dept. collaborates with the ERS Finance Department, who is responsible for paying out the grants into the fellows’ bank accounts. At the termination of each fellowship period, the ERS staff collects the end-ofproject reports from the fellows. The two competent full-time staff involved are the Head of Scientific Activities who holds a masters degree in biochemistry and has worked for 3 years at the ERS office, and the Scientific Activities Coordinator who holds a masters degree in physics and has several years work experience at the Swiss Federal Institute of Intellectual Property as a patent researcher. Show that your organisation has the required financial expertise and audit function for the programme. The ERS is a recognised, established, non-governmental organisation handling large congresses, scientific journals, fellowship programmes, external courses and seminars etc. It has an adequately staffed and well-functioning Finance Department based in Lausanne Switzerland with personnel of the required expertise and audit function for the programme. Its accounts are fully audited on a yearly basis by KPMG / Deloitte. Give an overview over the qualification and experience of the general staff responsible for the execution of the programme. Page 20 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges As explained in section 2.2, the day-to-day and general management of the fellowship programme is under the direct responsibility of two experienced full-time staff at the ERS Scientific Department in Lausanne. Specifically, the Head of Scientific Activities, Ms Carine Pannetier, holds a masters degree in biochemistry and has worked 3 years at the Scientific Department of the ERS office in Lausanne. She is responsible for the coordinating the Scientific Programme of the ERS Annual Congress, and she is also responsible for managing and preparing the work, agenda and minutes of the meetings of the ERS Scientific Committee. The Scientific Activities Coordinator, Ms. Josephine Ricou Yanmaz, holds a masters degree in physics and has several years of relevant work experience as a patent researcher from the Swiss Federal Institute of Intellectual Property. She joined the ERS Scientific Activities Dept. with a particular responsibility for coordination and successful implementation of the ERS fellowship programme, in line with decisions of the ERS Scientific and Executive committees. 2.5 Appropriateness of the scale of the programme Demonstrate that the number of fellowships suggested in your programme is appropriate in terms of achieving a strategic impact. The award of an ERS fellowship is recognised as very prestigious, and so it is extremely important for the individual receiving it, since this provides them with a unique opportunity to broaden his/her scientific as well as personal experiences. A stay in a different country to acquire new skills is usually highly-valued in the home country upon return of the fellow. A fellowship also often results in a life-long collaboration between the fellow, his/her home institution and the host, which strengthens the networks and collaborations between research groups and countries in Europe. In Europe, as well as in the rest of the world, lung diseases are among the leading causes of mortality and morbidity. The leading killers such as lung cancer, chronic obstructive pulmonary disease are strongly related to tobacco consumption, but other risk factors such as air pollution, allergens, infectious pathogens and toxic occupational agents also play an important role in the development of respiratory disease in Europe. Other major respiratory diseases that are seeing an increased prevalence and incidence in Europe are asthma, rhinitis, drug-resistant TB, pneumonia, sleep-related disorders etc. There is a crucial need for efforts to concentrate not only on prevention, but also for an expansion of the means dedicated to scientific research and treatment of lung disease. The work accomplished by the ERS to develop research and training opportunities, amongst others through the RESPIRE programme, will be essential if Europe is to come to the forefront of medical research and patient care. Thus although the respiratory science community is relatively small, it will be a major achievement to increase the support of experienced researchers to become leading investigators in their respective field. More than doubling the number of long-term postdoctoral fellowships in the proposed RESPIRE programme will therefore have a significant impact on building and maintaining scientific networks in the respiratory field in Europe. Describe the programme design elements that give it the capacity to adapt or expand easily? The programme is designed in such a way that it has the capacity to adapt to the fellow’s circumstances. For instance, if the fellow wishes to expand his fellowship, the RESPIRE programme gives the opportunity to extend his/her stay, and he may submit a new application. Page 21 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges The ERS will allow 1-year fellowships to be extended with one additional year. The new application will be evaluated on scientific merits. 2.6 Future development of the programme Describe the longer-term strategy of the programme and how you see its future development beyond the Community co-funded phase. In September 2007, the ERS has created the new position of Research Director. One of the main tasks of the Research Director is, together with the Scientific Committee, to assess the long-term strategy of the ERS fellowship programme and in particular the proposed RESPIRE programme with focus on post-doctoral positions. The future development of this programme is a process which has been commenced by the Research Director and Scientific Committee, and will be further discussed within the ERS during 2008. A final strategy is expected to be in place by the end of 2008. A recent overview of the ERS long-term strategy was started a few years ago. In brief, the future scientific strategy of the ERS set out several objectives for the long-term, among others the ERS will to a greater extent than previously focus to attract the best science and improve standards from low-income countries. The ERS Annual Congress will continuously strive to be the best forum for the presentation of breakthrough discoveries and attract abstracts from high-level research centres in Europe and worldwide. The ERS has also already commenced a process and will consider re-categorising fellowships in the future, depending on the location and the experience of applicants. This will imply greater support for experienced post-doc researchers, as well as continued support for young investigators with a more clinical profile. Describe how foreseen impact assessment and key indicators may serve to improve the evolution of the programme. The assessment of the impact of the RESPIRE programme will take place at regular intervals, normally every year. Key indicators of the success of the programme may include the number of applications submitted to the programme; the number of approved fellowships; the number of original research presented leading to publication; the number of presentations at national or international congresses dealing with the research as proposed in the fellowship; the number of collaborative projects emanating from the fellowships; the number of (research) awards linked to the fellowship; and the number of established collaborations that continue between home and host institutions after the fellowships are finished. Each of these indicators will be carefully recorded each year, and will be a helpful tool in the future evolution of the programme. B 3 Relevance and Impact to "Life-long training and Career development" 3.1 Openness of the programme to trans-national mobility Explain in detail the trans-national elements of your programme (e.g. the importance of incoming, outgoing, re-integration components as relevant). The ERS is a European organisation, and as such is keen to promote European science in the respiratory field. The ERS fellowship programme has the following aims: - Promoting science, research and training in respiratory medicine in Europe; Page 22 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges - Supporting the exchange in Europe of young scientists and clinicians actively involved in respiratory medicine; - Contributing to the diffusion and implementation of new techniques in Europe and internationally. The RESPIRE programme is a truly trans-national programme and welcomes all nationalities to apply. The only restriction is that the host-institution must be located in Europe. Therefore the programme can be seen as containing both incoming and outgoing components for fellowships where both home and host are located in Europe. The ERS as an international society is keen to promote talented researchers from outside Europe and to elevate their potential, and therefore it is important that they can be given the chance to have access to facilities that are available in Europe but rarely in their own country. Thus, in the past several fellowships have been awarded to non-Europeans (e.g. in 2005 and 2006 ERS awarded long-term research fellowships to researchers based in Brazil, Mexico, Peru, Australia, Turkey, Argentina and Indonesia) to undertake research in Europe. This part of the fellowship programme can be seen to contain incoming components only. The RESPIRE programme does not specifically offer re-integration components, but it does encourage fellows to return to their home institutions after completion of the fellowship, which as mentioned earlier, is explicitly stated at the end of the online application, enclosure 9, as well as in the rules “ERS Fellowships 2008”, enclosure 1. If applicable, describe the reasons for the chosen combination of trans-national elements. The reason for requiring the host institution to be located in Europe is that the ERS wants to stimulate European respiratory medical research. What specific efforts are made to attract non-nationals? As described above, the fellowship programme is open to all nationalities. Announcements for the fellowship programme are made internationally and are not restricted to Europe only, for instance on the ERS website, by sending out mass-email alerts to all 35,000 database contacts of the ERS (of which a significant proportion are non-European); advertising in the Annual Congress programme etc. see section 1.1 and in the European Respiratory Journal, which both can be accessed worldwide. The ERS fellowships are without exception always granted to so-called “nonnationals” as every fellow can be seen to be categorised as belonging to the “incoming mobility” type. The ERS funds 100% trans-national European exchanges and is also international since it also accepts researchers from outside Europe to come to Europe. Of the 14 long-term research fellowships awarded in 2006 by the ERS (note that this category has previously included both experienced and early-stage researchers), 4 fellows were being hosted at a European institute and were nationals based outside EU-27 i.e. Australia, Turkey, Argentina, Indonesia. 3.2 Contribution to diverse career development of researchers (broadening and deepening) Explain how the programme helps the fellows to deepen the skills within their discipline and/or to gain new skills in other disciplines/sectors (private-public) The overarching aim of the fellowship programme is to enable fellows to go to another country with the specific objective of deepening their skills within their discipline. The Page 23 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges fellows are asked to describe this in the project description as part of their application, and the objective of deepening their skills is one of the key elements of the programme and will be evaluated as such by the external experts. Although gaining new skills in other disciplines is not a general requirement of the programme, this is a natural consequence of the fellows’ stay at their host institutions located in a different country and often a different research environment. The fellows will improve their language skills, management skills and networking skills while conducting their research project in the given time-frame and in a different country. That this is the case is usually also confirmed in the fellows’ end-of-year report. Does the programme also offer support or training in non-scientific skills (e.g. management, presenting and publishing research results etc.)? As explained above, the programme in itself does not specifically offer support or training in non-scientific skills, but ERS fellows are encouraged, as stated in the Fellowship Rules, to engage in teaching, discussion and similar activities of the host institutions. In addition, ERS fellows are also invited to participate at specific sessions (open to all delegates who register to take part at the Congress) organised at the ERS Annual Congress which aim at developing the non-scientific skills of researchers. For instance in Stockholm 2007 a session on “How to write a Scientific Paper” was included in the Congress programme. The fellows will in a natural way become involved in taking responsibilities for management activities at their host institutions and they will be expected to present and publish research results e.g. at the ERS Annual Congress or other international congresses. As can be seen from the end-of-year report, the fellows usually have published and presented the outcomes of the research. In addition to that, they will also improve their language skills and their networking skills, as a consequence of the new situation to which they are exposed. 3.3 Career development support to fellows Explain how the programme contributes to the career development of the fellows. Being awarded an exclusive ERS fellowship after selection from a large number of candidates by an international evaluation process is an important milestone in the career of a postdoctoral fellow. The ERS is a highly recognised professional body and the pre-eminent society in respiratory medicine in Europe, well-known among all scientists with an interest in respiratory medicine and pneumologists in Europe and beyond. The ERS Annual Congress represents the largest gathering in respiratory medicine world-wide with an attendance of around 17,000 delegates. Thus, being able to demonstrate the acquisition and completion of a prestigious ERS fellowship signifies a truly important step in the career development of a fellow. In terms of specific aspects of career development, many times fellows emphasise the importance of the contacts that were made during the fellowship, and these have often contributed to them obtaining their present position or employment. Another relevant impact of the ERS fellowship is that it has contributed to deliver scientific outputs in the form of articles in scientific peer-reviewed journals. Explain any specific mentoring or support schemes in place to support career development Upon submission of a satisfactory end-of-project report, which will be published on the ERS website, fellows are eligible to join the Association of ERS Fellows, which is a valuable Page 24 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges support scheme for career and networking development. The Association’s directory provides a unique and invaluable resource of addresses, current professional activities, fellowship subjects and host institutes. It permits members to identify and contact colleagues. It may also serve as a useful recruitment pool. New fellows who work in Eastern Europe or in lowincome countries may benefit from a one-year free ERS full membership. The ERS office will contact fellows on a regular basis in order to update their profile on the website. In addition to the above, the ERS has started to highlight the fellowship programme by means of a dedicated ERS Fellows Session during the Annual ERS congress, see enclosure 18. ERS fellows are invited and encouraged to attend this ERS Fellows Lunch. It is a means of presenting results, meeting with other fellows and sharing experiences. The ERS issues an ERS Certificate to each fellow who has completed the end-ofproject report, including the host report. Finally, an ERS fellow’s website is also currently in preparation, and is anticipated to become available by the end of March 2008. This will form a valuable means of career development through communication and discussion among former and current ERS fellows, as well as future networking. In addition to these support schemes offered by the ERS, the fellows career development will also benefit from the mentor relationship established with the host. Frequently these relationships are maintained also after the fellow has returned to the home country, and result in fruitful collaborations and possible future projects. Describe any specific schemes to follow up career re-integration or return mechanisms if appropriate? Fellows are encouraged to return to their home institutions after completion of the fellowships, but no specific schemes for career re-integration or return mechanisms have been set up, see as previously indicated the “ERS Fellowships 2008”, enclosure 1, and at the very bottom of the online application form, enclosure 9. Describe any post-scheme network support offered to maintain relationships established during the fellowship? As explained above, the ERS supports the fellows post-scheme by means of offering them to become members of the ERS Fellows Association, a network consisting of ERS fellows. The fellows are also invited to take part in the dedicated “ERS Fellows” session at the ERS Annual Congress, see the agenda in enclosure 18. In addition, the fellows’ website will offer opportunities for networking and for the fellows to stay in touch and maintain their relationships. 3.4 Equal opportunities, including for resuming a research career after a break Explain the measures the programme takes to ensure equal opportunities. The RESPIRE programme values equal opportunities, and therefore invites both male and female, European and non-European, ERS members and non-ERS members to apply for fellowships. The final decision is then based purely on scientific merit and the quality of the submitted proposal, as elucidated in section 1.3. Describe the monitoring of success ratios of men/women, and appropriate targeting of fellows in areas where they are imbalanced, etc.). Page 25 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges The success ratios of men and women are monitored annually, and in 2007 of the 13 accepted long-term fellowship applications 7 were male and 6 female. Of the 17 accepted short-term fellowships 8 were male and 9 female. This indicates the success ratio of the ERS fellowships of men and women is perfectly balanced. Does the programme encourage applications from researchers after a career break? Yes. There is no age limitation for the applicants, so those who have had a career break have an equal opportunity to success. 3.5 Relevance for the European Research Area13 (ERA) of the scientific field covered by the programme's calls Chronic respiratory diseases include some of Europe’s most disabling diseases which are third in terms of mortality, morbidity, incidence, prevalence and costs. The total annual cost of respiratory diseases in Europe is estimated to be around €102 billion, mainly due to lost working days. Apart from high costs, respiratory diseases also impose a major burden to the patients, in particular due to a significant decrease in life quality. The ERS, as the main scientific society in the respiratory field in Europe, promotes research into chronic disabling respiratory diseases in both children and adults, including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, lung cancer and sleep-related respiratory disease. Research into a better understanding of these diseases is of vital importance as this will lead to more effective treatments, which will improve quality of life and reduce the financial burden to the European society. In the medical / life sciences field scientific, professional medical bodies such as the ERS that operate at European level, are key stakeholders in many aspects of facilitating the exchange between experts / scientists and thus overcoming the fragmentation that exists in the ERA. Many times such bodies at European level have a key role in setting up and maintaining pan-European clinical and/or research-based multi-disciplinary networks that could develop and lead larger independent clinical trials. Such pan-European clinical trial initiatives, free from commercial interest and not politically governed, are invaluable and will also serve to strengthen the competitiveness of the ERA. Internationally the influence of the ERS is growing, and it now cooperates with its sister organisations and other key stakeholders in a recently launched process aimed at reviewing methodologies relevant to research and clinical practice. Moreover, the ERS has succeeded over the last decade to expand its membership considerably by meeting the growing demands of our world-wide membership. The ERS now has the largest respiratory congress in the world. This makes ERS to be one of the most relevant key stakeholders in respiratory science in the ERA. The ERS RESPIRE programme will therefore not only boost the careers of the fellowship recipients, it will also promote the ERA by facilitating the platform needed to enhance and maintain scientific networks, and retaining promising researchers in Europe. This will in turn be an important step towards conquering some of the most disabling diseases in Europe. How does the programme proposed contribute to the general policy objectives of ERA? The proposed RESPIRE programme is well-aligned with the general policy objectives of the ERA. It attempts to increase the competence and competitiveness of European post-doctoral Page 26 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges fellows and research in the respiratory field. Specifically, it will contribute significantly to the following policy objectives: Networking of existing centres of excellence in Europe and the creation of virtual centres through the use of new interactive communication tools, through the use of the interactive fellows’ website. More coherent implementation of national and European research activities and closer relations between the various organisations of scientific and technological cooperation in Europe. More abundant and more mobile human resources: o Greater mobility of researchers and introduction of a European dimension to scientific careers o More prominence to the place and role of women in research o Stimulating young people’s taste for research and careers in science. Sharing knowledge and bringing together scientific communities, companies and researchers of Western and Eastern Europe. Improving the attraction of Europe for researchers from the rest of the world. Demonstrate that your programme contributes to the overall objective and expected impact of the COFUND action (developing of the trans-national dimension, increasing the number of trans-national fellows or improving the fellows' conditions) With aid of the COFUND action, our RESPIRE programme will more than double the transnational movement of fellows in the respiratory science field in Europe, which will significantly increase the trans-national dimension in this area. This demonstrates clearly that the proposed programme will contribute to the overall objective and expected impact of the COFUND action. Indicate the evolution of own budget over time. If relevant, justify any reductions from previous years' budget. The ERS decided to increase the budget for long-term research fellowships this year, in particular the budget allocated to experienced researchers, as the value of more post-doctoral opportunities in the respiratory field has been acknowledged. This budget has been relatively constant in the past few years. It is the ambition of the ERS to further increase the budget allocated to fellowships in the future, in particular those aiming at experienced researchers as is proposed in the current RESPIRE programme, see figure 3 on page 14. The development of the ERS fellowship programme as a whole is however related to the evolution of the future ERS budget as a whole. How does your programme contribute to specific ERA goals (e.g. efforts to overcome fragmentation and to contribute to long-lasting international cooperation, development of common research methods/approaches, etc.)? The RESPIRE programme will support experienced investigators in the development, acquisition and application of advanced research procedures that may not be available in their own institution and that require a period in a well established centre in another European country. Thus, fellows supported in the RESPIRE programme will build up valuable contacts and collaboration during their stay in the host country. Experience from fellows who previously participated in the ERS fellowship programme indicates that these contacts are often maintained once the fellows have returned to their home institutions, thereby building Page 27 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges long-lasting international cooperation and contributing to scientific networks in Europe. Research methods and approaches learnt by the fellows at their host institutions are generally brought back to their home country, which is an important element in the development of common methodology across Europe. The use of these common methods will facilitate future collaboration and will reduce fragmentation in European research. The RESPIRE programme will also aid in the participation and collaboration of European research groups and clinics in common study protocols, which will further increase the excellence of European networks in the respiratory field in comparison with for instance American counterparts. For fellowships awarded outside of ERA, is there a suitable return element foreseen? Fellowships offered in the proposed RESPIRE programme will not be awarded outside ERA, so a return element is therefore not included. 3.6 Impact of the programme to the development of the researchers careers in the ERA Describe how the programme assures that the researchers can choose as freely as possible their research topics and research institutions/supervisors according to their individual career development needs The ERS RESPIRE programme as well as the ERS fellowship programme as a whole does not impose any restrictions with regard to the opted research/training topic within the field of respiratory research. The host institutions may be chosen freely within Europe, thereby ensuring the ERA objectives and fortifying European respiratory research. The applicants are totally free to choose their research/training according to their individual career development needs, as long as it is within the field covered by respiratory medicine which spans the wide range of topics such as chronic, inflammatory, infectious, cancer, allergic, epidemiology, and paediatric disorders. The applicant is requested to justify and demonstrate the value and relevance of the project and how it contributes to promoting respiratory medicine in Europe. No restrictions are imposed with regard to the fellow’s choice of host institution, so long as it is located in Europe, thereby boosting respiratory research in the ERA, and subject that the host accepts to receive the fellow as demonstrated by the duly completed “Host Acceptance Form”, enclosure 11. The opinion of the three expert reviewers and the final discussion in the Scientific Committee will be decisive to assessing the relevance and feasibility of the proposed project to developing and strengthening respiratory research in the ERA. Explain how and why the award of a fellowship under your programme will help to boost the researchers' careers after the end of the fellowship. Being awarded an exclusive ERS RESPIRE fellowship after selection from a large number of candidates by an international evaluation process is an important milestone in the career of a post-doctoral fellow. The ERS is highly recognised, and is the main society within the respiratory field in Europe, well-known among all scientists and pneumologists in Europe as well as outside Europe. Thus, being able to demonstrate the completion of a prestigious ERS fellowship is a truly significant step in the career development of a fellow. Page 28 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges The well-established ERS fellowship programme has over the years contributed to boost the careers of now highly ranked scientists and clinicians. Many ERS fellows emphasise the importance of the contacts that were made during the fellowship, and how these have often contributed to obtaining their present position or employment. The proposed ERS RESPIRE programme, with the additional added-value of the prestigious Marie Curie COFUND action, will therefore provide a unique opportunity to enhance post-doctoral career opportunities in the respiratory research area in Europe, thereby promoting the ERA. Page 29 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges Table 1: Indicative long-term strategic programming of the programme Type of mobility: incoming§ Proposal Acronym: RESPIRE Average 20032007)* 100 2007 2008 2009 2010 2011 80 121 145 169 193 Own long-term indicative funding planned by the programme (kEUR)** 1998 Year of start of the programme * for years only where the programme was fully operational ** including 10% overhead and 5% management costs. These percentages have also been added for comparison reasons to the average costs of 2003-2007 and to the budget of 2007, even though these were not added as such to the internal fellowship programme budget in those years. § Please note: for the purpose of this application we consider our mobility as incoming only, since the ERS is an international organisation and does not grant fellowships from a national perspective. Most of the fellowships are within Europe, but the European home and host countries are different for each fellow. Some of the fellowships are awarded to fellows who are based outside Europe, and in such cases the host country is required to be in Europe. Hence the choice to consider all fellowships as incoming for the current application. Page 30 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges Table 2: Yearly breakdown of requested Co-funding Proposal Acronym: RESPIRE Type of mobility: incoming§ Year COFUND action before COFUND Year 1 Year 2 Year 3 action 80 201 Total budget of calls (committed as a result of calls under that year) (kEUR)** of which - own budget 80 121 - Community contribution 0 80 2 5 Fellowship-years selected 0 5 Fellowship-years executed under COFUND * the current application is for 36 months ** including 10% overhead and 5% management costs § Year 4* TOTAL 242 282 725 145 97 6 6 169 113 7 7 435 290 18 18 Please note: for the purpose of this application we consider our mobility as incoming only, since the ERS is an international organisation and does not grant fellowships from a national perspective. Most of the fellowships are within Europe, but the European home and host countries are different for each fellow. Some of the fellowships are awarded to fellows who are based outside Europe, and in such cases the host country is required to be in Europe. Hence the choice to consider all fellowships as incoming for the current application. Page 31 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges Table 3: Cost breakdown per fellowship type Proposal Acronym: RESPIRE Cost categories (average Outgoing fellows Incoming fellows§ Re-integration costs) phase 35,000 Living allowance (EUR/year)* 0 Travel/mobility allowance (EUR/year)** 0 Research cost contribution (EUR/year)** 3,500 Overheads (EUR/year) 1,750 Management costs (EUR/year) 40,250 TOTAL (EUR/year) 16,100 Community contribution (EUR/year) (40% of total) 18 Number of eligible fellows 12 Average duration of fellowships (months) 18 Number of eligible fellowyears 724,500 Total budget (EUR) 289,800 Community Contribution (EUR) * Based on average ERS long-term fellowship costs of 2007, which in turn are based on the EMBO subsistence rates (see enclosures 1 and 15). The yearly increase due to inflation is not taken into account in these calculations. ** Contribution by host. § Please note: for the purpose of this application we consider our mobility as incoming only, since the ERS is an international organisation and does not grant fellowships from a national perspective. Most of the fellowships are within Europe, but the European home and host countries are different for each fellow. Some of the fellowships are awarded to fellows who are based outside Europe, and in such cases the host country is required to be in Europe. Hence the choice to consider all fellowships as incoming for the current application. Page 32 of 33 RESPIRE REspiratory Science Promoted by International Research Exchanges PART C For this part of Annex I, tables A3.1 and A3.2 of GPFs have to be included. Page 33 of 33