Second International Symposium on Cancer Biology
“Cancer: Found in Translation”
2-3 September 2009
Day 1:
8.45am
Welcome by Professor Peter Gregson, Vice-Chancellor, Queen’s University Belfast
9.00am - 1.00pm
Session 1:
“Chromatin and DNA Damage”
Chair:
Richard Kennedy
9.00-9.35am
“Chromatin Modifying Enzymes: Their Function and Role in Cancer”
Tony Kouzarides, Wellcome Trust/Cancer Research UK Gurdon Institute,
University of Cambridge
9.35-10.10am
“The Cancer Epigenome”
Jean-Pierre Issa, Leukemia Department, MD Anderson Cancer Center,
University of Texas
10.10-10.45am “Targeting Epigenetic Therapies”
Robert Brown, Imperial College London and the Institute of Cancer Research
10.45-11.15am Tea / Coffee
Chair:
Tony Kouzarides
11.15-11.50am “Genomic Instability and Cancer: Lessons from Analysis of Bloom's Syndrome”
Ian Hickson, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital,
University of Oxford
11.50-12.25pm “DNA Damage Repair Pathways as Cancer Therapeutic Targets”
Derek Richard, Queensland Institute of Medical Research, Brisbane, Australia
12.25-1.00pm
The McClay Foundation Lecture:
“Synthetic Lethal Strategies for Exploiting DNA Repair Defects in Cancer”
Alan Ashworth, Breakthrough Breast Cancer Research Centre,
Institute of Cancer Research, London
1.00-2.00pm
Lunch
2.00 - 4.50pm
Session 2:
“Hypoxia and Oxygen Tension”
Chair:
Dennis McCance
2.00-2.35pm
“The VHL Tumor Suppression Gene: Oxygen Sensing and Cancer”
Bill Kaelin, Dana-Farber Cancer Institute, Harvard Medical School, Boston
2.35-3.10pm
“Hypoxia, Inflammation and Cancer”
Cormac Taylor, School of Medicine & Medical Science, Conway Institute, Dublin
3.10-3.40pm
Tea / Coffee
Chair:
Terry Lappin
3.40-4.15pm
“Oxygen Sensing by the HIF Hydroxylases”
Peter Ratcliffe, The Nuffield Department of Clinical Medicine, University of Oxford
4.15-4.50pm
"Disorders of the Oxygen-Regulated EPO Pathway: Implications for Cancer"
Frank Lee, School of Medicine, University of Pennsylvania
5.00-7.00pm
Poster Session with Wine and Beer
7.00-9.00pm
Buffet Dinner - Europa Hotel
Day 2:
8.30am - 12.30pm
Session 3:
“Tumour Microenvironment”
Chair:
David Waugh
8.30-9.05am
“Imaging the Metastatic Process”
Erik Sahai, Cancer Research UK London Research Institute
9.05-9.40am
“Stroma as the Target in Radiation Carcinogenesis”
Mary Helen Barcellos-Hoff, Department of Radiation Oncology, New York
University Langone School of Medicine
9.40-10.15am “Understanding and Targeting the Functions of Macrophages in the Tumor
Microenvironment”
Johanna Joyce, Memorial Sloan-Kettering Cancer Center, New York
10.15-10.45am Tea / Coffee
Chair:
Johanna Joyce
10.45-11.20am “Breast Microenvironment as Predictor of Clinical Outcome”
Morag Park, Rosalind and Morris Goodman Cancer Centre, McGill University,
Montreal, Canada
11.20-11.55pm “Regulation of Macrophage Function by the Tumor Microenvironment: Role of
Hypoxia and Angiopoietin-2”
Claire Lewis, Tumour Targetting Group, University of Sheffield Medical School
11.55-12.30pm “Tumour Stroma, Bystander Killing and the Destruction of Escape Variants”
Hans Schreiber, University of Chicago Medical Center
12.30-1.30pm Lunch
1.30- 3.15pm
Session 4:
“Survival Signalling”
Chair:
Dean Fennell
1.30-2.05pm
“Resistance Mechanisms to EGFR Targeted Therapies”
Pasi Jänne, Dana-Farber Cancer Institute, Boston
2.05-2.40pm
“Biomarkers of Response to Anti EGFR Therapy in Colorectal Cancer”
Pierre Laurent-Puig, University of Paris
2.40-3.15pm
“mTOR Signalling and Cancer”
John Blenis, Department of Cell Biology, Harvard Medical School, Boston
3.15-3.45pm
Tea / Coffee
Chair:
Dennis McCance
3.45-5.30pm
Proffered Session:
“BRCA1 Protein Expression as a Predictor of Outcome following Chemotherapy in
Sporadic Epithelial Ovarian Cancer”
Jennifer Quinn, CCRCB
“Identification of Novel Targets Synthetically Lethal with Loss of PTEN”
Nuala McCabe, Almac Diagnostics
“Chronic but not Acute Hypoxia Exposure Impairs Replication Restart after
Reoxygenation via Replisome Disassembly”
Isabel Pires, The Cancer Research UK/MRC Gray Institute for Radiation
Oncology and Biology, University of Oxford
“Does Hypoxia Play a Role in the Failure of Androgen Ablation Therapy for Prostate
Cancer?”
Stephanie McKeown, School of Biomedical Sciences, University of Ulster
“The Role of c-FLIP in Regulating Non-small Cell Lung Cancer Cell Death”
Kelly Redmond, CCRCB
“Scaffolding Complexes at the IGF-I Receptor - Regulation of Cell Adhesion by
RACK1/PDLIM2 Interaction”
Deirdre Buckley, Department of Biochemistry, University College Cork
“Acetylation of the retinoblastoma protein during keratinocyte differentiation is
important for nuclear localization of the protein”
Adam Pickard, CCRCB
7.00pm
Pre-dinner drinks – Canada Room, QUB
8.00pm
Dinner – Great Hall, QUB