Principal Investigator/Program Director (Last, First, Middle):
Guo, Maolin
BIOGRAPHICAL SKETCH
NAME
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POSITION
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Guo, Maolin
Associate Professor
eRA COMMONS USER NAME
MGUO8871
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Shanxi University, Taiyuan, China
Shanxi University, Taiyuan, China
Edinburgh University, Edinburgh, UK
University of California, Irvine, CA
DEGREE
(if applicable)
B.S.
M.S.
Ph.D.
postdoc
training
YEAR(s)
1989
1992
2000
2001-2004
FIELD OF STUDY
Biochemistry
Bioinorganic Chemistry
Chemistry/Biochemistry
Molecular Biology and
Structural Biology
A. Positions and Honors.
Positions and Employment
2001-2001
Postdoctoral Researcher, Laboratory of Dr. Barbara K. Burgess, Department of Molecular
Biology and Biochemistry, University of California, Irvine, CA
2002-2004
Postdoctoral Researcher, Laboratory of Dr. Thomas L. Poulos, Department of Molecular
Biology and Biochemistry, University of California, Irvine, CA
2004-2008 Assistant Professor, Department of Chemistry and Biochemistry, University of
Massachusetts, Dartmouth, MA
2008-present Associate Professor, Department of Chemistry and Biochemistry, University of
Massachusetts, Dartmouth, MA
2007-present Graduate Faculty, Department of Chemistry, University of Massachusetts, Amherst, MA
Honors and Awards
1997-2000
Overseas Research Student Award, UK
1997-2000
Sir David Baxter scholarship, University of Edinburgh, UK
2001
Faculty Career Development Award, University of California, CA
2001
SBIC award for young scientists to attend ICBIC10, Society of Biological Inorganic Chemistry
B. Selected peer-reviewed publications (selected from over 50 peer-reviewed publications)
1) M. Guo, H. Sun, S. Bihari, J. Parkinson, R. Gould, S. Parsons, P. J. Sadler, Stereo-selective formation of
seven-coordinate titanium(IV) monomer and dimer complexes of ethylenebis(o-hydroxyphenyl)glycine),
Inorganic Chemistry, 2000, 39, 206-215
2) M. Guo and P. J Sadler, Competitive binding of the anticancer drug titanocene dichloride to N,N´-ethylene-bis-(ohydroxyphenylglycine) and adenosine triphosphate: a model for Ti IV uptake and release by transferrin
J. Chem. Soc., Dalton Trans., 2000, 7-10.
3) Guo, M., Sun, H., McArdle,H. J., Gambling, L., Sadler, P. J.Understanding the mechanism of action
of the anticancer drug titanocene dichloride: TiIV uptake and release by human serum transferrin and
Ti2-hTF uptake by cancer cell. Biochemistry, 2000, 33, 10023-10033
4) M. Guo, Z. Guo, P. J. Sadler Ti(IV) targets phosphoesters on nucleotides: implications for the mechanism of action of
the anticancer drug titanocene dichloride, J. Biol. Inorg. Chem., 2001, 6, 698-707
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Principal Investigator/Program Director (Last, First, Middle):
Guo, Maolin
5) Guo, M., Sulc, F., Ribbe, M., Farmer, P. J., Burgess B. K. Direct assessment of the reduction potential
of the [4Fe-4S]1+/0 couple of the Fe protein from Azotobacter vinelandii. J. Am. Chem. Soc., 2002 124,
12100-12101
6) M. Ribbe, Y. Hu, M. Guo, B. Schmid and B. K. Burgess The FeMoco-deficient MoFe protein produced by a nifH-deletion
strain of Azotobacter vinelandii shows unusual P-cluster features, J. Biol. Chem., 2002, 277, 23469-23476.
7) W. Zhong, J. Parkinson, M. Guo, P. J. Sadler Unusual features for zirconium(IV) binding to human serum transferrin
J. Biol. Inorg. Chem., 2002, 7, 589-599
8) D. Alexeev, H. Zhu, M. Guo, W. Zhong, D. Hunter, W. Yang, D. Campopiano and P. J. Sadler, A novel Protein Mineral
Interface, Nature Structural Biology, 2003, 10, 297-302 (Highlight: see Comment in: Nature Struct. Biol.
2003,;10:240-1: Press release:http://www.nature.com/nsmb/press_release/nsb0403.html)
9) W. Zhong, D. Alexeev, I. Havey, M. Guo, D. Hunter, H. Zhu, D. Campopiano, P. J. Sadler, Assembly of an Oxo
Zirconium(IV) cluster in a protein cleft, Angew. Chem. Int. Ed., 2004, 43, 5914-5918
10) M. Guo, I. Harvey, W. Yang, L. Coghill, D. Campopiano, J. Parkinson, R. MacGillivray, W. Harris,
P. J. Sadler, Synergistic anion and metal binding to the ferric-iron binding protein from Neisseria gonorrheae
J. Biol. Chem., 2003, 278, 2490-2502.
11) M. Guo, B. Bhaskar, Huiying. Li, Tiffnay. P. Barrows, Thomas. L. Poulos, Crystal structure and characterization of a
cytochrome c peroxidase-cytochrome c site specific cross-link,
Proc. Natl. Acad. Sci. USA, 2004, 101, 5940-5945.
12) P. Yang,* R. Ren, M. Guo, *, A. Song, X. Meng, C. Yuan, Q. Zhou, H. Chen, Z. Xiong, X. Gao,Double-strand hydrolysis
of DNA by a magnesium (II) complex with diethylenetriamine.
J. Biol. Inorg. Chem. 2004, 9, 495-506 (* corresponding authors)
13) M. Guo,* I. Harvey, D. Campopiano, P. J. Sadler,* Short Oxo-Titanium(IV) bond in bacterial
transferrin: a protein target for metalloantibiotics. Angew. Chem. Int. Ed. 2006, 45(18), 2758-2761.
(* corresponding authors, selected in Preview of Angew. Chem. Int. Ed. 2006, 45(17), 2639).
14) S. Feng, Zhu, L. Lu and M. Guo, Single-crystal metal–organic microtubes self-assembled from
designed D3 symmetrical nanoclusters with a capped triple-helix pentanuclear M5O6 core,
Chem. Commun., 2007, 4785-4787. (Highlighted by Nature China, see comments in Research Highlights:
http://www.nature.com/nchina/2007/071003/full/nchina.2007.202.html.
16) Y. Wei and M. Guo*, Hydrogen peroxide triggered prochelator activation, subsequent metal
chelation, and attenuation of the Fenton reaction, Angew. Chem. Int. Ed., 2007, 46, 4722-4725.
17) Y. Tong and M. Guo*, Cloning and characterization of a novel periplasmic heme-transport protein
from the human pathogen Pseudomonas aeruginosa, J. Biol. Inorg. Chem. 2007, 12, 735-750 .
18) M. Guo, C. Perez, Y. Wei, E. Rapoza, G. Su, F. Bou-Abdallah and N. D. Chasteen, Iron-binding
properties of plant phenolics and cranberry’s bio-effects, Dalton Trans., 2007, (43), 4951 - 4961
19) Y. Wei and M. Guo, Hydrogen peroxide triggered prochelator activation, subsequent metal
chelation, and attenuation of the Fenton reaction, Angew. Chem. Int. Ed., 2007, 46, 4722-4725
20) Ho, W., Li, H., Eakanunkul, S., Tong, Y., Wilks, A., Guo, M., and Poulos T. L. Holo- and apostructures of bacterial periplasmic heme binding proteins. J. Biol. Chem. 2007,282, 35796-3580220)
21) C. A. Perez, Y. Tong, M. Guo, Iron Chelators as Potential Therapeutic Agents for Parkinson’s
Disease, Curr. Bioactive Comp. 2008, 4, 150-158 (invited review)
22) C. A. Perez, Y. Wei, M. Guo, Iron-binding and anti-Fenton properties of baicalein and baicalin,
J. Inorg. Biochem. 2009, 103, 326-332.
22) Y. Tong and M. Guo, Bacterial heme-transport proteins and their heme-coordination modes,
Arch. Biochem. Biophys. 2009, 483, (1) 1-15 (cover of ABB, 1st issue of 2009)
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Principal Investigator/Program Director (Last, First, Middle):
Guo, Maolin
23) Y. Wei and M. Guo, A novel H2O2-triggered anti-Fenton fluorescent pro-chelator excitable with
visible light, Chem. Commun., 2009, 1413-1415
24) Wang, Q., Lu, L., Yuan, C.,Pei, K., Liu, Z., Guo M.,* , Zhu, M.* Potent inhibition of protein
tyrosine phosphatase 1B by copper complexes: implication to copper toxicity in biological systems,
Chem. Commun, 2010, 46, 3547-3549.
25) Wei, Y., Zhang, Y., Liu, Z., Guo, M* A novel profluorescent probe for detecting oxidative stress
induced by metal and H2O2 in living cells, Chem. Commun. 2010, 46: 4472-4774 (cover of issue 25);
Selected as a Hot article: http://www.rsc.org/Publishing/Journals/cc/HotArticles.asp )
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