Principal Investigator/Program Director (Last, First, Middle): Guo, Maolin BIOGRAPHICAL SKETCH NAME Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. POSITION TITLE FOUR PAGES. Follow this format for each person. DO NOT EXCEED Guo, Maolin Associate Professor eRA COMMONS USER NAME MGUO8871 EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION Shanxi University, Taiyuan, China Shanxi University, Taiyuan, China Edinburgh University, Edinburgh, UK University of California, Irvine, CA DEGREE (if applicable) B.S. M.S. Ph.D. postdoc training YEAR(s) 1989 1992 2000 2001-2004 FIELD OF STUDY Biochemistry Bioinorganic Chemistry Chemistry/Biochemistry Molecular Biology and Structural Biology A. Positions and Honors. Positions and Employment 2001-2001 Postdoctoral Researcher, Laboratory of Dr. Barbara K. Burgess, Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 2002-2004 Postdoctoral Researcher, Laboratory of Dr. Thomas L. Poulos, Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 2004-2008 Assistant Professor, Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 2008-present Associate Professor, Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 2007-present Graduate Faculty, Department of Chemistry, University of Massachusetts, Amherst, MA Honors and Awards 1997-2000 Overseas Research Student Award, UK 1997-2000 Sir David Baxter scholarship, University of Edinburgh, UK 2001 Faculty Career Development Award, University of California, CA 2001 SBIC award for young scientists to attend ICBIC10, Society of Biological Inorganic Chemistry B. Selected peer-reviewed publications (selected from over 50 peer-reviewed publications) 1) M. Guo, H. Sun, S. Bihari, J. Parkinson, R. Gould, S. Parsons, P. J. Sadler, Stereo-selective formation of seven-coordinate titanium(IV) monomer and dimer complexes of ethylenebis(o-hydroxyphenyl)glycine), Inorganic Chemistry, 2000, 39, 206-215 2) M. Guo and P. J Sadler, Competitive binding of the anticancer drug titanocene dichloride to N,N´-ethylene-bis-(ohydroxyphenylglycine) and adenosine triphosphate: a model for Ti IV uptake and release by transferrin J. Chem. Soc., Dalton Trans., 2000, 7-10. 3) Guo, M., Sun, H., McArdle,H. J., Gambling, L., Sadler, P. J.Understanding the mechanism of action of the anticancer drug titanocene dichloride: TiIV uptake and release by human serum transferrin and Ti2-hTF uptake by cancer cell. Biochemistry, 2000, 33, 10023-10033 4) M. Guo, Z. Guo, P. J. Sadler Ti(IV) targets phosphoesters on nucleotides: implications for the mechanism of action of the anticancer drug titanocene dichloride, J. Biol. Inorg. Chem., 2001, 6, 698-707 PHS 398/2590 (Rev. 09/04) Page 8 Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Guo, Maolin 5) Guo, M., Sulc, F., Ribbe, M., Farmer, P. J., Burgess B. K. Direct assessment of the reduction potential of the [4Fe-4S]1+/0 couple of the Fe protein from Azotobacter vinelandii. J. Am. Chem. Soc., 2002 124, 12100-12101 6) M. Ribbe, Y. Hu, M. Guo, B. Schmid and B. K. Burgess The FeMoco-deficient MoFe protein produced by a nifH-deletion strain of Azotobacter vinelandii shows unusual P-cluster features, J. Biol. Chem., 2002, 277, 23469-23476. 7) W. Zhong, J. Parkinson, M. Guo, P. J. Sadler Unusual features for zirconium(IV) binding to human serum transferrin J. Biol. Inorg. Chem., 2002, 7, 589-599 8) D. Alexeev, H. Zhu, M. Guo, W. Zhong, D. Hunter, W. Yang, D. Campopiano and P. J. Sadler, A novel Protein Mineral Interface, Nature Structural Biology, 2003, 10, 297-302 (Highlight: see Comment in: Nature Struct. Biol. 2003,;10:240-1: Press release:http://www.nature.com/nsmb/press_release/nsb0403.html) 9) W. Zhong, D. Alexeev, I. Havey, M. Guo, D. Hunter, H. Zhu, D. Campopiano, P. J. Sadler, Assembly of an Oxo Zirconium(IV) cluster in a protein cleft, Angew. Chem. Int. Ed., 2004, 43, 5914-5918 10) M. Guo, I. Harvey, W. Yang, L. Coghill, D. Campopiano, J. Parkinson, R. MacGillivray, W. Harris, P. J. Sadler, Synergistic anion and metal binding to the ferric-iron binding protein from Neisseria gonorrheae J. Biol. Chem., 2003, 278, 2490-2502. 11) M. Guo, B. Bhaskar, Huiying. Li, Tiffnay. P. Barrows, Thomas. L. Poulos, Crystal structure and characterization of a cytochrome c peroxidase-cytochrome c site specific cross-link, Proc. Natl. Acad. Sci. USA, 2004, 101, 5940-5945. 12) P. Yang,* R. Ren, M. Guo, *, A. Song, X. Meng, C. Yuan, Q. Zhou, H. Chen, Z. Xiong, X. Gao,Double-strand hydrolysis of DNA by a magnesium (II) complex with diethylenetriamine. J. Biol. Inorg. Chem. 2004, 9, 495-506 (* corresponding authors) 13) M. Guo,* I. Harvey, D. Campopiano, P. J. Sadler,* Short Oxo-Titanium(IV) bond in bacterial transferrin: a protein target for metalloantibiotics. Angew. Chem. Int. Ed. 2006, 45(18), 2758-2761. (* corresponding authors, selected in Preview of Angew. Chem. Int. Ed. 2006, 45(17), 2639). 14) S. Feng, Zhu, L. Lu and M. Guo, Single-crystal metal–organic microtubes self-assembled from designed D3 symmetrical nanoclusters with a capped triple-helix pentanuclear M5O6 core, Chem. Commun., 2007, 4785-4787. (Highlighted by Nature China, see comments in Research Highlights: http://www.nature.com/nchina/2007/071003/full/nchina.2007.202.html. 16) Y. Wei and M. Guo*, Hydrogen peroxide triggered prochelator activation, subsequent metal chelation, and attenuation of the Fenton reaction, Angew. Chem. Int. Ed., 2007, 46, 4722-4725. 17) Y. Tong and M. Guo*, Cloning and characterization of a novel periplasmic heme-transport protein from the human pathogen Pseudomonas aeruginosa, J. Biol. Inorg. Chem. 2007, 12, 735-750 . 18) M. Guo, C. Perez, Y. Wei, E. Rapoza, G. Su, F. Bou-Abdallah and N. D. Chasteen, Iron-binding properties of plant phenolics and cranberry’s bio-effects, Dalton Trans., 2007, (43), 4951 - 4961 19) Y. Wei and M. Guo, Hydrogen peroxide triggered prochelator activation, subsequent metal chelation, and attenuation of the Fenton reaction, Angew. Chem. Int. Ed., 2007, 46, 4722-4725 20) Ho, W., Li, H., Eakanunkul, S., Tong, Y., Wilks, A., Guo, M., and Poulos T. L. Holo- and apostructures of bacterial periplasmic heme binding proteins. J. Biol. Chem. 2007,282, 35796-3580220) 21) C. A. Perez, Y. Tong, M. Guo, Iron Chelators as Potential Therapeutic Agents for Parkinson’s Disease, Curr. Bioactive Comp. 2008, 4, 150-158 (invited review) 22) C. A. Perez, Y. Wei, M. Guo, Iron-binding and anti-Fenton properties of baicalein and baicalin, J. Inorg. Biochem. 2009, 103, 326-332. 22) Y. Tong and M. Guo, Bacterial heme-transport proteins and their heme-coordination modes, Arch. Biochem. Biophys. 2009, 483, (1) 1-15 (cover of ABB, 1st issue of 2009) PHS 398/2590 (Rev. 09/04) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): Guo, Maolin 23) Y. Wei and M. Guo, A novel H2O2-triggered anti-Fenton fluorescent pro-chelator excitable with visible light, Chem. Commun., 2009, 1413-1415 24) Wang, Q., Lu, L., Yuan, C.,Pei, K., Liu, Z., Guo M.,* , Zhu, M.* Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implication to copper toxicity in biological systems, Chem. Commun, 2010, 46, 3547-3549. 25) Wei, Y., Zhang, Y., Liu, Z., Guo, M* A novel profluorescent probe for detecting oxidative stress induced by metal and H2O2 in living cells, Chem. Commun. 2010, 46: 4472-4774 (cover of issue 25); Selected as a Hot article: http://www.rsc.org/Publishing/Journals/cc/HotArticles.asp ) PHS 398/2590 (Rev. 09/04) Page Continuation Format Page