Updated 13 August 2014
DMG
CURRICULUM VITAE
DON MARSHALL GASH, PH.D.
BUSINESS ADDRESS:
Department of Anatomy and Neurobiology
University of Kentucky College of Medicine
Room MN220, Medical Science Building
Lexington, Kentucky 40536-0298
Phone: (859) 323-5820
Fax: (859) 323-5946
E-mail: dongash@email.uky.edu
EDUCATION:
B.S. in Zoology, University of Kentucky,
Lexington, Kentucky, 1967
Ph. D. in Biology, Dartmouth College
Hanover, New Hampshire, 1975
Postdoctoral Fellowship in Cancer Research
University of Southern California, 1975-77
RESEARCH AND PROFESSIONAL EXPERIENCE:
2013-present
Director/Test Facility Manager, GLP Neuroscience Service Center, University of
Kentucky College of Medicine, Anatomy and Neurobiology
1993-present
Alumni Professor and Chair, University of Kentucky College of Medicine, Anatomy and
Neurobiology
1999-2007
Director, Research Magnetic Resonance Imaging and Spectroscopy Center, University of
Kentucky College of Medicine
1996-1998
Acting Director, Research Magnetic Resonance Imaging and Spectroscopy Center, University
of Kentucky College of Medicine
1987-93
Professor, University of Rochester School of Medicine, Neurobiology and Anatomy
1982-87
Associate Professor, University of Rochester School of Medicine, Neurobiology and Anatomy
1977-81
Assistant Professor, University of Rochester School of Medicine, Rochester, New York,
Anatomy and the Center for Brain Research
1975-77
Postdoctoral Research Training Fellow, University of Southern California School of Medicine,
Los Angeles, California, Department of Anatomy
1971-75
Graduate Studies, Dartmouth College, Hanover, New Hampshire, Departments of Biology and
Anatomy
1968-71
Captain, USAF, Deputy Director of Material, AFSPPF; provided managerial support for national
level research projects
10 May 2012
Don M. Gash
HONORS:
2007
2001
2000-2007
1993-present
1985-1992
1967
William R Willard Dean’s Recognition Award, College of Medicine
Albert D. and Elizabeth H. Kirwan Memorial Prize for Research and Scholarly
Achievement
Wethington Research Award, University of Kentucky
Endowed Alumni Chair, University of Kentucky Medical Center
Javits Neuroscience Investigator Award
John W. Oswald Award for Outstanding Undergraduate Research and Creativity
GOOD LABORATORY PRACTICE TRAINING:
19-20 May 2010: GLP Management Training and Consultation. Lexington KY Conducted by
Deborah Eyer Garvin, Pacific Rim Consulting, Inc.
11-12 January 2010: GLP Essentials for Technical Staff and GLPs for Study Directors and
Management. Lexington KY Conducted by Deborah Eyer Garvin, Pacific Rim Consulting
8-9 August 2011: Annual GLP Training for Technical Staff, Study Directors and Management,
Lexington KY Conducted by Hal Patterson, Director of Quality Assurance, ISTA Pharmaceuticals, Inc.
22-23 April 2012: Developing a GLP Compliant Program in a University Setting. Society for Quality
Assurance, Miami, Florida
INVESTIGATIONAL NEW DRUG STUDIES:
Investigator – Sponsor of IND 10111: Methionyl Glial Cell-Line Derived Neurotrophic Factor (human,
recombinant, E. Coli, Amgen) Delivered with Medtronic SynchroMed Infusion System, Intraputamenal.
2001 – 2002. Amgen (Thousand Oaks, CA) assumed responsibility for the IND in November, 2002.
PATENTS & PATENT APPLICATIONS (IN THE PUBLIC DOMAIN):
Steven S. Gill, Don M. Gash, Greg A. Gerhardt. Method of Treating Parkinson’s Disease by
Intraputamenal Infusion of Glial Cell-Line Derived Neurotrophic Factor. United States and
European patent pending
Steven S. Gill, Don M. Gash, Greg A. Gerhardt. Method of Treating Parkinson’s Disease by
Convection- Enhanced Infusion of Glial Cell-Line Derived Neurotrophic Factor to the Putamen.
United States and European patent pending
Luke Bradley, Don M. Gash, Greg A. Gerhardt, John D. Glass. Amidated Dopamine Neuron
Stimulating Peptides for CNS Dopaminergic Upregulation. United States and European patent
pending
RECENT RESEARCH SUPPORT:
Medtronic Master Research Agreement (DM Gash, PI) Medtronic, Inc., Minneapolis, MN. Delivery
of Selected Small Molecules to the Brain
Medtronic and Eli Lilly Master Research Agreement (DM Gash, co-PI with GA Gerhardt)
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Don M. Gash
Medtronic, Inc., Minneapolis, MN and Eli Lilly, Indianapolis, IN Pre-clinical Testing of GDNFv
Alnylam Master Research Agreement (DM Gash, co-Investigator; R Grondin, PI)
Alnylam Pharmaceuticals, Boston. Pre-clinical Testing of Alpha-synuclein siRNA
COMPLETED FUNDING SUPPORT (LAST 5 YEARS):
P01 AG13494 (D.M. Gash, Director)
NIH-NIA Aging of Central Dopaminergic Systems in Primates
02/18/97 - 1/31/10
The central hypothesis of this Program Project is that changes in central dopaminergic
pathways constitute a fundamental component of age-associated motoric declines. Currently, our
studies are focusing on dopamine neurons in the substantia nigra and their projections to the caudate
nucleus, putamen and globus pallidus of the basal ganglia. Neurochemical, electrophysiological and
MRI studies are underway analyzing key junctures in the neural circuitry regulating motor functions in
the basal ganglia of behaviorally characterized female rhesus monkeys ranging in age from young
adulthood to old age (5 – 25+ years old).
P50 NS39787 (G.A. Gerhardt, Director)
NIH-NINDS
Restoration of Dopamine Function in Parkinson’s Disease (Project 3: Quantitative Morphometric and
Immunocytochemical Analysis of Functional Recovery in Parkinson Rhesus Monkeys. D.M.
Gash - PI
09/30/99 - 07/31/10
The central hypothesis of this Parkinson’s Disease Research Center Grant is that site-specific,
chronic delivery of the trophic factor GDNF into the parkinsonian brain will protect and restore injured
CNS dopamine neurons. Ongoing studies are focused on behavioral, neurochemical and MRI analysis
rhesus monkeys with pronounced parkinsonian features receiving intracerebral infusions of GDNF.
NATIONAL/INTERNATIONAL MEETINGS AND INVITED PRESENTATIONS: 1998 – 2013
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William Harvey Research Conference on Novel Mechanisms of Neurodegeneration:
Neurotrophins, Cytokines and Inflammation, London, England, January 29-30, 1998
GDNF National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, April 7,
1998
First Joint Meeting of the European Neuropeptide Club and the Summer Neuropeptide
Conference, Gent Belgium, May 6-9, 1998
National Institute of Aging Workshop on Age-Related Neurobehavioral Research: An Integrative
Cognitive Neuroscience Agenda for the 21st Century, June 3-5, 1998.
GDNF Oklahoma Medical Research Foundation, Oklahoma City, OK, September 24, 1998
GDNF Investigators Meeting, Sponsored by Amgen, Inc., New York, New York October 12,
1998
Winter Conference for Brain Research, Workshop on Trophic Factors and the Human Brain: Is
Site Specific Delivery Important and is it Possible? Snowmass Village, Colorado, January 29,
1999
GDNFSanders Brown Center on Aging Seminar Series, Lexington, Kentucky, March 5, 1999
University Brain Awareness Week Lecture, Lexington Kentucky, March 17, 1999
International Symposium: Degeneration and Repair in the nervous System, Seville, Spain,
November 18-23, 1999
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Don M. Gash
National Institute on Aging and National Center for Research Resources Workshop, Aging
Nonhuman Primate Resources, Bethesda Maryland January 18-19,2000
Society for Neuroscience, “Behavioral recovery in parkinsonian rhesus monkeys: chronic
infusion of GDNF upregulates ventral striatal and dopamine functions.” New Orleans,
Louisiana, November 4-9, 2000
Neurochemistry Winter Conference, Keynote Lecture, “Programmed chronic delivery of GDNF
for the treatment of Parkinson’s disease,” Sölden, Austria, March 17-22, 2001
American Society for Neurotransplantation and Repair, “Pharmacological MRI mapping of basal
ganglia circuitry in awake rhesus monkeys: changes in aging and Parkinson’s disease.”
Clearwater, Florida, May 3-6, 2001
American Aging Association: Preconference Symposium: Nonhuman Primate Models of Aging,
Madison, Wisconsin, May 31-June1, 2001.
John Hopkins University, Bloomberg School of Public Health, “GDNF: Regeneration and
Functional Recovery in the Aged and Parkinsonian Brain,” October 23, 2001
National Institute on Aging, Gerontology Research Center, “Universal Motor Slowing in Aging”
Baltimore, MD, January 7, 2002
National Neurology Forum, Controversies in Neurology, Plenary Address “GDNF Therapy for
Parkinson’s Disease,” Madrid, Spain, February 9, 2002
University of Navarra, “GDNF Therapy for Parkinson’s Disease,” Pamplona, Spain, February 11,
2002
Medical College of Georgia, “fMRI Studies in Awake Nonhuman Primates,” Augusta, GA, March
12, 2002
Amgen, Inc. “Overview of GDNF Studies in Nonhuman Primates”
Thousand Oaks, CA,
September 18, 2002
Sanders Brown Center on Aging “Aging, Parkinson’s Disease and GDNF Therapy,” University of
Kentucky, Lexington, KY, October 4, 2002
Society for Neuroscience, “Chronic intracerebral GDNF infusion improves motor functions and
upregulates the nigrostriatal dopaminergic system in aged rhesus monkeys,” Orlando, FL,
November 6, 2002
Winter Conference on Brain Research.“Trophic Factor Therapy, What Works and What Does
Not?” Panel organizer and speaker, Snowbird, UT, January 30, 2003
Life Sciences without Boundaries Conference. Neuroscience, Panelist, Cincinnati, Ohio, March
10, 2002
Cell Transplantation and Parkinson’s Disease: Where Do We Go From Here? (MJ Fox
Foundation and Kinetics Foundation) Preclinical Models (Co-chair) San Francisco, CA, March
25 & 26, 2003
Baltic Summer School: Trophic Factor Therapy for Parkinson’s Disease. University of Kiel,
Germany, August 27, 2003
Amgen Phase 2 GDNF Clinical Trial Outcome Evaluation Meeting, Chicago, IL, August 4-5,
2004
Fox Foundation for Parkinson’s Disease. GDNF Summit, New York, NY, Oct 14-15, 2004
Amgen DSMB and Investigators’ Meeting, Thousand Oaks, CA, Nov 11, 2004
Udall Centers for Excellence for Parkinson’s Disease Research – 6th Annual Meeting,
Washington, DC Nov 30-Dec 2, 2004
Winter Conference on Brain Research: Special Poster Presentation: Unilateral intraputamenal
GDNF improves bilateral motor functions in patients with Parkinson’s disease. Copper
Mountain, CO, January 24-30, 2004
Winter Conference on Brain Research. Chair of Panel Session: Cells, “Genes or Machines:
What’s best for treating Parkinson’s disease?” Breckenridge, CO Jan 26, 2005
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Don M. Gash
University of Helsinki, GDNF: The Human Dimension; Helsinki, Finland, September 6, 2005
Udall Centers for Excellence for Parkinson’s Disease Research – 7h Annual Meeting, Boston,
MA; September 20-22, 2005
Amgen. GDNF Preclinical Data Meeting. Thousand Oaks, CA November 11, 2005
Winter Conference on Brain Research. Workshop: Translational Neuroscience and Parkinson’s
Disease: Obstacles to Progress. Steamboat, CO Jan 26, 2006.
Mayo Clinic, Jacksonville. GDNF for Parkinson’s Disease: From Nonhuman Primates to
Patients. Jacksonville, FL March 3, 2006
Banbury Conference on Parkinson’s Disease: Insights from Genetic and Toxin Models. “Toxininduced and age-associated parkinsonism in rhesus monkeys.” Cold Spring Harbor, NY May
15, 2006
1ST International Conference on the Biology and Therapeutic Potential of GDF-5: Use of
Neurotrophic Factors in PD. Boston, MA , October 25, 2006
Udall Centers Meeting : Trichloroethylene, Mitochondrial Toxicity and Parkinsonism, University
of Pittsburgh, PA, September 25-27, 2007
Aging Symposium on the Role of Genes, Environment and Chance in Determining Aging. CNS
Mitochondrial Dysfunctions and Age-associated Motor Declines in Rhesus Monkeys. 37th
Annual Meeting of the American Aging Association, Boulder CO May 30-June 2, 2008
Hereditary Disease Foundation, Progress towards a Clinical Trial of RNAi-based Therapy in HD,
July 16-17, 2008, New York, New York
Organizer of the Lexington Conference on Translational Neuroscience: Models of Aging,
Lexington, KY, Oct 8-10, 2008
Udall Centers Annual Meeting, DNSP-11, Chicago, IL Oct 21-23, 2008
Lundbeck Foundation Symposium: GDNF: Lessons Learned and Future Prospects,
Copenhagen, May 18, 2009 videocast www.lundbeckfonden.dk/en/donm.gash.asp
Institute of Biotechnology, GDNF: Lessons Learned and Future Prospects University of Helsinki,
Finland, May 20, 2009
World Congress on Huntington’s Disease; Developing RNAi Therapeutics targeting Huntingtin
with Local CNS Delivery: Nonhuman Primate Studies. (Poster Presentation) Vanvouver BC,
September 15, 2009
Lilly/Medtronic Advisory Meeting: Intraparenchymal Delivery for the Treatment of Parkinson’s
Disease. Dallas/Fort Worth; February 18, 19, 2010
NIH Meeting: Optimizing the Use of Sham Neurosurgical Procedures in Clinical Trials for
Neurodegenerative Diseases: Scientific and Ethical Considerations. Bethesda, MD; June 30July 1, 2010
Neurology Grand Rounds: Back to the Future: Targeted Drug Delivery for Parkinson’s Disease.
Continuing Education University of Kentucky College of Medicine. 23 August 2011
Neuroscience Symposium: Intracranial Drug Delivery Systems for Treatment of Neurological
Disease. Continuing Education University of Kentucky College of Medicine. 19 November 2011
Targeted Drug Delivery Conference: Intraputamenal Infusion of siRNA for Huntington’s Disease.
San Francisco. 4-5 May 2012
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Don M. Gash
OTHER PROFESSIONAL RESPONSIBILITIES:
Scientific Advisory Board of the American Paralysis Association, 1986 - 1994.
Member of the Neuroscience, Behavior and Sociology of Aging Review Subcommittee A, National
Institute on Aging. 1990 - 1994, Chair of Committee, 1994.
Review manuscripts for Nature, PNAS, Neuroscience, Journal of Neuroscience, Neuroscience Letters,
Annals of Neurology, Experimental Neurology
University of Kentucky Research Foundation Board of Directors, Executive Committee Member,
1999-2001
Board of Scientific Counselors, National Institute on Drug Abuse, Intramural Research Program,
January 2003 -2006, Chair 2005-2006
NIH Reviewer: Recent Examples
 NIDA Board of Scientific Counselors, Baltimore, MD, Jan 11, 2007
 NINDS Training Grant and Career Development Review Committee, Bethesda, MD Jan 24-24,
2007
 NINDS K99R00 Review Panel, Washington, DC, July 2. 2007
 NIA Special Emphasis Panel, Animal Resources, Phone Review, Feb 11, 2008
 NINDS NSD-B Study Section, Baltimore, MD Feb 28, 2008
 NNA-NIA Program Review, May 19, 2008
 NIDA-BSC Program Review, May 31-June 1, 2009
Member of Neurological Sciences Training (NST-2) Subcommittee r, NINDS-NIH October 30, 2008 thru
June 30, 2011
DOCTORAL STUDENTS TRAINED:
Pre (P)
Post (G)
Trainee
Year
Completed
Subsequent Training or First
Faculty Position
G
J. Wiseman (MS)
1979
Senior scientist
Ciba-Geigy Pharmaceuticals, NJ
Physician
G
D. Roher (MS)
1983
SUNY Medical School
Neurosurgeon
P
J. Scholer (w/ J. Sladek)
1981
Asst. Professor Anatomy LSU
Private Business, New Orleans, LA
Asst. Professor, State Medical School
Rio de Janeiro, Brazil
Psychologist, NY Mental Retardation
& Developmental Disabilites
Private Practice
Janeiro, Brazil
Assoc. Professor
Medical School
Current Position (if different)
Private Practice
P
G. Brito (w/G.J.
Thomas)
S. Sharoun (w/M.
Notter)
P
T. Collier (PhD) (w/ J.
Sladek)
1985
G
J. Herman (PhD)
1986
G
J. Lopez-Lozano (PhD)
1986
Scientist University of Rochester
Medical Center
Postdoc, Univ. of Michigan Mental
Health Research Inst.
Asst. Professor, Clinica Puerta de
Hierro, Univ. Autonoma, Madrid,
Spain
P
J. Kordower (PhD)
1987
Asst. Research Professor
University of Rochester
Professor Rush Presbyterian Medical
School, Chicago
P
H. White (MD)
1988
Asst. Professor
Medical College of Virginia
Chief, Rehabilitation Medicine, Jewish
Home & Hospital NY, NY
P
1982
1984
Rio de
Rush
Professor, University of Cincinnati
Page 6 of 21
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Don M. Gash
P
M. Fiandaca (MD)
1988
Asst. Professor, Univ. of
Massachussetts Medical Center
Private Practice
Maryland
P
M. Kaniucki (MD, PhD)
1988
Asst. Professor
Capital Federal, Argentina
Private Practice
Argentina
DOCTORAL STUDENTS TRAINED (CON’T):
Pre (P)
Post (G)
Trainee
Year
Completed
Subsequent Training or First
Faculty Position
G
F. Marciano (MD, PhD)
1989
Medical Student SUNY Albany
P
1989
P
G. Bing (MD, PhD)
V. Theerapancharoen
(MD)
G
S. Pearlman (PhD)
1991
P
R. Smith (PhD)
1991
G/P
F. Junn (MD)
1993
Postdoc, NYU
Professor
Mahidol University, Thailand
Technical Writer, Fisons
Pharmaceuticals Rochester NY
Scientist, Schering Plough Bloomfield,
NJ
Dept. of Neurosurgery, Univ. of
Toronto
P
Z. Zhang (MD)
1993
P
Y. Ai (MD)
1994
P
M. Bresjanac (MD)
P
G. Seigel (PhD)
1990
Current Position (if different)
Neurosurgeon, Barrows Research
Inst. Phoenix, Arizona
Assoc. Professor, Anatomy &
Neurobiology, University of KY
Program Specialist, NIA Baltimore,
MD
Chief Resident Neurosurgery
University of Toronto
1994
Capital Inst. of Medicine Beijing,
China
Capital Inst. of Medicine Beijing,
China
Ljubljana School of Medicine,
Slovenia
Assoc. Professor Anatomy &
Neurobiology, University of KY
Scientist III Anatomy & Neurobiology
,University of KY
Asst. Professor, Ljubljana School of
Medicine, Slovenia
1994
SUNY Albany
Scientist, University of Rochester
Asst. Professor
Okayama
Medical School Okayama, Japan
Associate Professor
Moravian College
K. Kakai (MD) (w/ J.
Hansen)
1994
P
P
C. Kearns (PhD)
Y. Miyoshi (MD)
1997
1997
Okayama Medical School
Okayama, Japan
Asst. Professor Wingate University
NC
Neurosurgeon Okayama, Japan
P/G
2001
University of KY College of Pharmacy
P
Gloria Umberger
N. Maswood (PhD) (w/
G. Gerhardt)
2001
P/G
R. Grondin (PhD)
2001
P
J. Zhang (MD)
2003
P/G
Y. Chen
2005
P
Xiuquan He
2007-2009
P
A. Richardson
2009
Scientist, NIA Baltimore, MD
Centre de Recherche en
Neurobiologie Quebec, Canada
Capital Inst. of Medicine Beijing,
China
Postdoctoral scholar, Anatomy &
Neurobiology University of KY
Shandong University China MD/PhD
Program
Assistant Professor, Anatomy &
Neurobiology University of KY
P
J. Sonne
2013
P
M. Stenslik
2014
G
L. Potts
2015
Research Scientist
Meyers-Squibb
Bristol-
Assoc. Professor Anatomy &
Neurobiology, University of KY
Biotech Consultant
US Army Officer
Current graduate student, Anatomy &
Neurobiology University of KY
Post-Doctoral Scholar, Anatomy and
Neurobiology
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Don M. Gash
PEER REVIEWED, BOOK CHAPTERS, REVIEWS AND OTHER PUBLICATIONS:
1.
Gash, DM Electrophoresis pattern in mouse serum proteins due to dieldrin, endrin, and DDT
poisoning. Undergraduate Research and Creativity, University of Kentucky, Lexington,
Kentucky; pp. 4-17 (1967).
2.
Gash, DM Properties of Rathke's pouch and surrounding ectoderm transplanted into the adult
rat. Doctoral Dissertation, Dartmouth College; p. 117, 1975.
3.
Gash, DM, T Roos and W Chambers. Development of Rathke's Pouch tissue transplanted into
adult hypophysectomized female rats. Neuroendocrinology 19:214-226, 1975.
4.
Gash, DM and W Chambers. Development of intratesticular implants of rat pituitary primordia.
Experientia 33:1512-1513 (1977).
5.
Gash, DM, N Ahmad and J Schechter. Cytodifferentiation of pituitary primordia transplanted to
the kidney capsule of adult hosts. Anat. Rec. 189:149-160, 1977.
6.
Schechter, J, DM Gash and N Ahmad. Neuroembryogenesis of ventral hypothalamus
transplanted to kidney capsule. Cell Tiss. Res. 190:247-254, 1978.
7.
Gash, DM, C Sladek and D Scott. Cytodifferentiation of the supraoptic nucleus correlated with
vasopressin synthesis in the rat. Brain Res. 181:345-355, 1980.
8.
Gash, DM, N Ahmad, R Weiner and J Schechter. Development of presumptive mammotrophs
in isografts is dependent on the endocrine state of the host. Endocrinology 106:1246-1252,
1980.
9.
Gash, DM and JR Sladek, Jr. Vasopressin neurons grafted into Brattleboro rats: viability and
activity. Peptides 1:11-14, 1980.
10.
Hoffman, GE, LB Dick and DM Gash. Development of somatostatin neurons: Examination by
the technique of combined autoradiography and immunocytochemistry. Peptides 1, Suppl.
1:79-83, 1980.
11.
Gash, DM, CD Sladek and JR Sladek, Jr. A model system for analyzing functional
development of transplanted peptidergic neurons. Peptides 1, Suppl. 1:125-134, 1980.
12.
Sladek, CD, DM Gash, H Khachaturian, DE Scott and JR Sladek, Jr. Maturation of the
supraoptic nucleus: A multidisciplinary analysis. Peptides 1, Suppl. 1:51-67, 1980.
13.
Gash, DM, JR Sladek, Jr. and CD Sladek. Functional development of grafted vasopressin
neurons. Science 210:1367-1369, 1980.
14.
Gash, DM and DE Scott. Fetal hypothalamic transplants in the third ventricle of the adult rat
brain: Correlative scanning and transmission electron microscopy. Cell Tiss. Res. 211:191206, 1980.
15.
Gash, DM Brain transplants are next. Psychology Today, December, p. 116 (1981).
16.
Brito, GNO, GJ Thomas, SI Gingold and DM Gash. Behavioral characteristics of vasopressindeficient rats (Brattleboro strain). Brain Res. Bull. 6:71-75, 1981.
17.
Gash, DM, N Ahmad and J Schechter. Comparison of gonadotroph, thyrotroph and
mammotroph development in situ, in transplants, and in organ culture. Neuroendocrinology
34:222-228, 1982.
18.
Schechter, J, DM Gash and N Ahmad. Estradiol stimulation of pituitary primordia transplanted
to the kidney capsule. Cell Tiss. Res. 227:41-53, 1982.
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Don M. Gash
19.
Scott, D, DM Gash, JR Sladek, Jr., C Clayton, JA Mitchell, S Caldron and WK Paull.
Organization of the mammalian cerebral ventricular system: ultrastructural correlates of CSF Neuropeptide secretion. Front. of Hormone Res. 9:15-35 (1982).
20.
Brito, GNO, GJ Thomas, DM Gash and JH Kitchen. The behavior of Brattleboro rats. Ann.
N.Y. Acad. Sci. 394:740-748 (1982).
21.
Gash, DM, PH Warren, LB Dick, JR Sladek, Jr. and J Ison. Behavioral modification in
Brattleboro rats due to vasopressin administration and neural transplantation. Ann. N.Y. Acad.
Sci. 394:672-681 (1982).
22.
Warren, PW and DM Gash. Hyperreflexive Behavior in Brattleboro rats. Peptides 4:421-424,
1983.
23.
Gash, DM, GJ Boer, MFD Notter and JR Sladek, Jr. Transplanted vasopressin neurons and
central nervous system effects of vasopressin. Prog. Brain Res. 60:189-195 (1983).
24.
Gash, DM, G Boer, MFD Notter and JR Sladek, Jr. Development and function of transplanted
vasopressin neurons. Psychopharm. Bull. 19:308-310 (1983).
25.
Gash, DM and GJ Thomas. What is the importance of vasopressin in memory processes?
Trends NeuroSci. 6:197-198 (1983).
26.
Scharoun, SL, DM Gash and MFD Notter. In vitro and in vivo studies on development and
regeneration of vasopressin neurons. Peptides 5 (Suppl. 1):157-167 (1984).
27.
Scott, DE, D Sherman, FP Gibbs, WK Paull and DM Gash. The neuroanatomical and
neurovascular organization of normal fetal hypothalamic explants in the third cerebral ventricle
of Brattleboro rats with homozygous diabetes insipidus. Peptides 5(Suppl. 1):169-183 (1984).
28.
Notter, MFD., DM Gash, CD Sladek and SL Scharoun. Vasopressin in reaggregated cell
cultures of the developing hypothalamus: Brain Res. Bull. 12:307-313, 1984.
29.
Boer, GJ, N Schluter and DM Gash. A procedure for small volume brain grafting; vasopressin
cells in neonatal and adult Brattleboro rats. J. Neurosci. Methods 11:39-45, 1984.
30.
Sladek, JR, Jr., DM Gash and TJ Collier. Transplantation of peptidergic and aminergic
neurons. In: Catecholamines: Neuropharmacology and Central Nervous System - Therapeutic
Aspects, A.R. Liss, Inc., New York, 1984, pp. 211-217.
31.
Gupta, M, DL Felten and DM Gash. MPTP alters central catecholamine neurons in addition to
the nigrostriatal system. Brain Res. Bull. 13:737-742, 1984.
32.
Gash, DM Neural transplants in mammals: A historical overview. In: Neural Transplants:
Development and Function, (JR Sladek, Jr. and DM Gash, Editors), Plenum Press, New York,
1984, pp. 1-12.
33.
Sladek, JR, Jr. and DM Gash. Morphological and functional properties of transplanted
vasopressin neurons. In: Neural Transplants: Development and Function (JR Sladek, Jr. and
DM Gash, Editors), Plenum Press, New York, pp. 243-282, 1984.
34.
Gash, DM and JR Sladek, Jr. Functional and non-functional transplants: Studies with grafted
hypothalamic and preoptic neurons. Trends NeuroSci. 7:391-394, 1984.
35.
Gash, DM, SJ Wiegand, FF Marciano and JR Sladek, Jr. Plasticity of vasopressin neurons in
fetal hypothalamic transplants. In: Fetal Neuroendocrinology, Proceedings of a Symposium (F
Ellendorff, PD Gluckman, and N Parvizi, Editors), Perinotology Press, Ithaca, New York, 1984,
pp. 71-82.
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Don M. Gash
36.
Gupta, M, MFD Notter, S Felten and DM Gash. Differentiation characteristics of human
neuroblastoma cells in the presence of growth modulators and antimitotic drugs. Develop. Brain
Res. 19:21-29, 1985.
37.
Gash, DM, MFD Notter, LB Dick, AL Kraus, SH Okawara, S Wechkin and RJ Joynt. Cholinergic
neurons transplanted into the neocortex and hippocampus of primates: Studies on African
Green monkeys. In: Neural Grafting in the Mammalian CNS, (A Bjorklund and U Stenevi,
Editors), Elsevier, Amsterdam, 1985, pp. 595-603.
38.
Kaplan, AS, DM Gash, D Flood and PD Coleman. A Golgi study of hypothalamic transplants in
young and old host rats. Neurobiology Aging 6:205-211, 1985.
39.
Marciano, FF, DM Gash and JR Sladek, Jr. Transplanted vasopressin neurons: Structural and
functional correlates. In: Neural Grafting in the Mammalian CNS, (A Bjorklund and U Stenevi,
Editors), Elsevier, Amsterdam, 1985, pp. 617-627.
40.
Collier, TJ, DM Gash, V Bruemmer and JR Sladek, Jr. Impaired regulation of arousal in old age
and the consequences for learning and memory: Replacement of brain norepinephrine via
neuron transplants improves memory performance in aged F344 rats. In: Homeostatic
Functions and Aging (BB Davis and WG Wood, Editors), Raven Press, New York, 1985, pp. 99110.
41.
Thomas, GJ and DM Gash. Mammillothalamic tracts and representational memory. Behav.
Neurosci. 99:621-630, 1985.
42.
del Cerro, M, DM Gash, GN Rao, MFD Notter, SJ Wiegand and M Gupta. Intraocular retinal
transplants. Inv. Ophthalmol. Vis. Sci. 26:1182-1185, 1985.
43.
Lyness, J, AG Robinson, MN Sheridan and DM Gash. Antidiuretic effects of oxytocin in the
Brattleboro rat. Experientia 41:1444-1446, 1985.
44.
Boer, GJ, DM Gash, LB Dick and N Schluter. Vasopressin neuron survival in neonatal
Brattleboro rats; Critical factors in graft development and innervation of the host brain.
Neuroscience 15:1087-1109, 1985.
45.
Gash, DM, TJ Collier and JR Sladek, Jr. Neural transplantation: A review of recent
developments and potential applications to the aged brain. Neurobiology Aging 6:131-150
(1985).
46.
Schechter, J, DM Gash and N Ahmad. Mesenchymal influences on the development of the
adenohypophysis in the rat. Cell Tiss Res. 241:67-76, 1985.
47.
Kordower, JH and DM Gash. Animals and experimentation: An evaluation of animal models of
Alzheimer's and Parkinson's disease. Integrative Psych. 4:64-80 (1986).
48.
Gash, DM, MFD Notter and JH Kordower. Cognitive dysfunctions and neural implants. In:
Treatment Development Strategies for Alzheimer's Disease (T Crook, R Bartus, S Ferris and S
Gershon, Editors) Mark Rowley Assoc., Inc., Conn., pp. 567-584, 1986.
49.
Notter, MFD, M Gupta and DM Gash. Neuronal properties of monkey adrenal medulla in vitro.
Cell Tiss. Res. 244: 69-76, 1986.
50.
Herman, JP, GJ Thomas, JF Laycock, IB Gartside and DM Gash. Behavioral variability within
the Brattleboro and Long Evans rat strains. Physiol. Behav. 36:713-721, 1986.
51.
Herman, JP, GJ Thomas and DM Gash. Behavioral characteristics of Roman high avoidance
rats homozygous for diabetes insipidus (RHA:di/di). Behav. Brain Res. 20: 27-38, 1986.
52.
Marciano, FF and DM Gash. Structural and functional relationships of grafted vasopressin
neurons. Brain Res. 370:338-342, 1986.
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Don M. Gash
53.
Herman, JP, CD Sladek, JT Hansen and DM Gash. Characterization of a new rodent model of
diabetes insipidus: The Roman high avoidance rat homozygous for diabetes insipidus.
Neuroendocrinology 43:340-347, 1986.
54.
Kordower, JH, SY Felten, DL Felten and DM Gash. Behavioral sequelae following MPTP
administration in mice. In: MPTP: A neurotoxin producing a Parkinsonian syndrome (S Markey,
N Castagnoli, Jr, A Trevor and I Kopin, Editors), Academic Press, New York, pp. 413-417, 1986.
55.
Thomas, GJ and DM Gash. Differential effects of posterior septal lesions on dispositional and
representational memory. Behav. Neurosci. 100:712-719, 1986.
56.
Herman, JP, FF Marciano and DM Gash. Vasopressin administration prevents functional
recovery of the vasopressinergic neurosecretory system following neurohypophysectomy.
Neuroscience Letters 72:239-246, 1986.
57.
Gash, DM, MFD Notter, SH Okawara, AL Kraus and RJ Joynt. Amitotic neuroblastoma cells
used for neural implants in monkeys. Science 233:1420-1422, 1986.
58.
Collier, TJ, DM Gash and JR Sladek, Jr. Norepinephrine deficiency and behavioral senescence
in aged rats: Transplanted locus coeruleus neurons as an experimental replacement therapy.
Ann. NY Acad. Sci. 495:396-403, 1987.
59.
Kordower, JH, MFD Notter and DM Gash. Neuroblastoma cells in neural transplants:
neuroanatomical and behavioral analysis. Brain Research 417:85-98, 1987.
60.
del Cerro, M, DM Gash, GN Rao, MFD Notter, SJ Wiegand, S Sathi and C del Cerro. Retinal
transplants into the anterior chamber of the rat eye. Neuroscience 21:707-723, 1987.
61.
Schechter, J, DM Gash and N Ahmad. Rathke's pouch grafts in adult brain sites. Am. J. Anat.
178:55-64 (1987).
62.
Bohn, MC, FF Marciano, L Cupit and DM Gash. Adrenal medulla grafts enhance recovery of
striatal dopaminergic fibers. Science 237:913-916, 1987.
63.
Herman, JP, FF Marciano, SJ Wiegand and DM Gash. Selective cell death of magnocellular
vasopressin neurons in neurohypophysectomized rats following chronic administration of
vasopressin. J. Neurosci. 7:2564-2575, 1987.
64.
Notter, MFD, JH Kordower and DM Gash. Differentiated neuronal cell lines as donor tissue for
transplantation into the central nervous system. Ann. NY Acad. Sci. 495:767-770, 1987.
65.
Wiegand, SJ and DM Gash.
Intraventricular transplants of anterior hypothalamus:
Neurochemical and connectional specificity in morphologically distinct subtypes of neurophysincontaining neurons. Ann. NY Acad. Sci. 495:807-810, 1987.
66.
Kordower, JH, MFD Notter, HH Yeh and DM Gash. An in vivo and in vitro assessment of
differentiated neuroblastoma cells as a source of donor tissue for transplantation. Ann. NY
Acad. Sci. 495:606-621, 1987.
67.
del Cerro, M, DM Gash, MFD Notter, GN Rao, SJ Wiegand, LQ Jiang and C del Cerro.
Transplanting strips of immature retinal suspensions of dissociated retinal cell into normal and
extensively damaged eyes. Ann. NY Acad. Sci. 495:692-695, 1987
68.
Marciano, FF, SJ Wiegand, and DM Gash. The role of target-graft interactions in the functional
development of transplanted vasopressin neurons. Ann. NY Acad. Sci. 495:760-763, 1987.
69.
Lopez-Lozano, JJ, DM Gash, JF Leary, and MFD Notter. Survival and integration of
transplanted hypothalamic cells in the rat CNS after sorting by flow cytometry. Ann. NY
Acad.Sci. 495:736-739, 1987.
A
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Don M. Gash
70.
Gash, DM, JP Herman and GJ Thomas. Vasopressin and animal behavior. In: Vasopressin:
Principles and Properties (DM Gash and GJ Boer, Editors), Plenum Press, New York, pp. 517547, 1987.
71.
Gash, DM. Neural implants: A strategy for the treatment of Alzheimer's disease. In:
Alzheimer's Disease: Problems, Prospects, and Perspectives (H Altman, Editor), Plenum Press,
New York, pp. 165-170, 1987.
72.
Joynt, RJ and DM Gash. Neural Transplants: Are We Ready? Ann. Neurol. 22:455-456 , 1987.
73.
Gash, DM. Neural transplantation: Potential therapy for Alzheimer's disease. J. Neural Trans.,
Suppl. 24:301-308, 1987.
74.
Sladek, JR, Jr. and DM Gash. Nerve cell grafting in Parkinson's disease. J. Neurosurg. 68: 337351, 1988.
75.
Wiegand, SJ, WF Silverman, DM Gash and JR Sladek, Jr. Transplanted vasopressin neurons
form appropriate connections with the host brain. In: Recent Progress in Posterior Pituitary
Hormones (S Yoshida and L Share, Editors), Elsevier, Amsterdam, pp. 23-31, 1988.
76.
Gash, DM, MFD Notter, JT Hansen, G Bing and S-H Okawara. Human organ donor adrenals:
Fine structure, plasticity and viability. In: Transplantation into the Mammalian CNS, (DM Gash
and JR Sladek, Jr., Editors), Elsevier, Amsterdam, Prog. Brain Res. 78: 559-565, 1988.
77.
del Cerro, M, MFD Notter, DA Grover, DM Gash, L Qi Jiang and C del Cerro. Retinal
transplants into adult eyes affected by phototoxic retinopathy. In: Transplantation into the
Mammalian CNS (DM Gash and JR Sladek, Jr., Editors), Elsevier, Amsterdam, Prog. Brain Res.
78:125-130, 1988.
78.
Hansen, JT, G Bing, MFD Notter and DM Gash. Paraneuronal grafts in unilateral 6hydroxydopamine-lesioned rats: morphological aspects of adrenal chromaffin and carotid body
glomus cell implants. In: Transplantation into the Mammalian CNS (DM Gash and JR Sladek,
Jr., Editors), Elsevier, Amsterdam, Prog. Brain Res. 78:507-511 (1988).
79.
Bohn, MC., FF Marciano, L Cupit and DM Gash. Recovery of dopaminergic fibers in striatum of
the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse is enhanced by grafts of
adrenal medulla. In: Transplantation into the Mammalian CNS (DM Gash and JR Sladek, Jr.,
Editors) Elsevier, Amsterdam, Prog. Brain Res. 78:535-542 (1988).
80.
Notter, MFD., DM Gash and JF Leary. Flow cytometric analyses and sorting of neural cells for
transplantation. In: Transplantation into the Mammalian CNS (DM Gash and JR Sladek, Jr.,
Editors) Elsevier, Amsterdam, Prog. Brain Res. 78:605-611 (1988).
81.
Gash, DM, MS Fiandaca, JH Kordower and JT Hansen. Adrenal medulla transplants in rodents
and nonhuman primates: Regenerative responses in the host brain. In: Progress in Parkinson
Research (F Hefti and WJ Weiner, Editors), Plenum Press, New York, pp. 181-186, 1988.
82.
Wiegand, S. and DM Gash. Organization and efferent connections of transplanted
suprachiasmatic nuclei. J. Comp. Neurol. 267: 562-579, 1988.
83.
Wiegand, SJ and DM Gash. Characteristics of vasculature and neurovascular relations of
intraventricular anterior hypothalamic transplants. Brain Res. Bull. 20:105-124, 1988.
84.
Bing, G, MFD Notter, JT Hansen and DM Gash. Comparison of adrenal medullary, carotid
body and PC-12 cell grafts in 6-OHDA lesioned rats. Brain Res. Bull. 20:399-406, 1988.
85.
Collier, .J, DM Gash and JR Sladek, Jr. Transplantation of norepinephrine neurons into aged
rats improves performance of a learned task. Brain Res. 448:77-87, 1988.
86.
Notter, MFD, I Irwin, JW Langston and DM Gash. Neurotoxicity of MPTP and MPP+ in vitro:
Characterization using specific cell lines. Brain Res. 456:254-262, 1988.
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87.
Thomas, GJ and DM Gash. Differential effects of hippocampal ablations on dispositional and
representational memory in the rat. Behav. Neurosci. 102:635-642, 1988.
88.
Fiandaca, MS, JH Kordower, JT Hansen, S-S Jiao and DM Gash. Adrenal medullary autografts
into the basal ganglia of Cebus monkeys: Injury-induced regeneration. Exp. Neurol. 102:76-91,
1988.
89.
Hansen, JT, JH Kordower, MS Fiandaca, S-S Jiao, MFD Notter and DM Gash. Adrenal
medullary autografts into the basal ganglia of Cebus monkeys: Graft viability and fine structure.
Exp. Neurol. 102:65-75, 1988.
90.
Kordower, JH, JR Sladek, Jr., MS Fiandaca, G Bing and DM Gash. Tyrosine hydroxylaseimmunoreactive somata within the primate subformical organ: Species specificity. Brain Res.
461:221-229, 1988.
91.
Yeh, HH, MFD Notter, JH Kordower and DM Gash. Synapse-competence of LA-N-2 human
neuroblastoma cells in coculture with rat striated muscle cells. Neurosci. 27:309-315, 1988.
92.
Hansen, JT, MFD Notter, S-H Okawara and DM Gash. Organization, fine structure and viability
of the human adrenal medulla: Considerations for neural transplantation. Ann. Neurol. 24:599609, 1988.
93.
Kordower, JH and DM Gash. Animal models of age-and disease related cognitive decline:
perspectives on the models and therapeutic strategies. Neurobiology Aging 9:685-689, 1988.
94.
Kordower, JH, RT Bartus, M Bothwell, G Schatteman, and DM Gash. Nerve growth receptor
immunoreactivity in the non-human primate (Cebus apella): Distribution, morphology, and colocalization with cholinergic enzymes. J. Comp. Neurol. 277:465-486, 1988.
95.
Fiandaca, MS, JH Kordower, JT Hansen and DM Gash. Adrenal Medullary tissue grafting in
Parkinson's disease. J. Neurosurg. 69:150-152, 1988.
96.
Gash, DM and JR Sladek, Jr. Neural transplantation: problems and prospects - where do we
go from here? Mayo Clin Proc. 64:363-367, 1989.
97.
White, H. and DM Gash. Neural transplants: Potential applications for treating brain damage.
In: Neurotrauma: Treatment, Rehabilitation and Related Issues (ME Miner and KA Wagner,
Editors.) Butterworths, Stoneham, MA, pp. 3-13, 1989.
98.
Hansen, JT, G Bing, MFD Notter, JH Kordower, MS Fiandaca and DM Gash. Adrenal
chromaffin cells as transplants in animal models of Parkinson's disease. J. Elect. Micr. Tech.
12:308-315, 1989.
99.
Gash, DM Direct comparisons of CNS directed therapies are needed. Neurobio. Aging 10:645646, 1989.
100. Kordower, JH, MS Fiandaca, MFD Notter, JT Hansen and DM Gash. Scientific basis for
dopaminergic brain grafting. In: Therapy of Parkinson's Disease, (WC Koller and G Paulson,
Editors), Marcel Dekker, New York, pp. 443-472,1989.
101. Kordower, JH, RT Bartus, FF Marciano and DM Gash. Telencephalic cholinergic system of the
new world monkey (Cebus, apella): Morphological and cytoarchitectonic assessment and
analysis of the projection to the amygdala. J. Comp. Neurol. 279:528-545, 1989.
102. Marciano FF, SJ Wiegand, JR Sladek, Jr. and DM Gash. Fetal hypothalamic transplants
promote survival and functional regeneration of axotomized adult supraoptic magnocellular
neurons. Brain Res. 483:135-142, 1989.
103. Kordower, JH, DM Gash, M Bothwell, L Hersh and EJ Mufson. Nerve growth factor receptor
and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's
patients. Neurobiology Aging 10:287-294, 1989.
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Don M. Gash
104. Notter, MFD, JT Hansen, S Okawara and DM Gash. Rodent and primate adrenal medullary
cells in vitro: phenotypic plasticity in response to coculture with C6 glioma cells or NGF. Exp.
Brain Res. 76:38-46, 1989.
105. Earnest, DJ, CD Sladek, DM Gash and SJ Wiegand. Specificity of circadian function in
transplants of the fetal suprachiasmatic nucleus. J. Neurosci. 9:2671-2677, 1989.
106. Lopez Lozano, JJ, MFD Notter, DM Gash and JF Leary. Selective flow cytometric sorting of
viable dopamine neurons. Brain Res. 486:351-356, 1989.
107. Bing, G, MFD Notter, JT Hansen, C Kellogg, JH Kordower and DM Gash. Cografts of adrenal
medulla with C6 glioma cells in rats with 6-OHDA-induced lesions. Neurosci. 34:687-697, 1990.
108. Grafstein, B and DM Gash. Research on recovery from CNS injury. Exp. Neurol. 107:111-112,
1990.
109. Hansen, JT, MS Fiandaca, JH Kordower, MFD Notter and DM Gash. Striatal adrenal
medulla/sural nerve cografts in hemiparkinsonian monkeys. In: Neural Transplantation, (SB
Dunnett and S-J Richards, Editors), Elsevier, Amsterdam, Prog. Brain Res. 82:573-580, 1990.
110. Kordower, JH, MS Fiandaca, MFD Notter, JT Hansen and DM Gash. NGF-like trophic support
from peripheral nerve for grafted rhesus adrenal chromaffin cells. J. Neurosurg. 73:418-428,
1990.
111. Thomas, GJ and DM Gash. Movement-associated neural excitation as a factor in spatial
representational memory in rats. Behav. Neurosci. 104:552-563, 1990.
112. Pearlman, SH, P Rubin, HC White, SJ Wiegand and DM Gash. Fetal hypothalamic transplants
into whole brain irradiated rats: Graft morphometry and host behavioral responses. Int. J.
Radiat. Oncol. Biol. Phys. 19:293-300, 1990.
113. Hansen, JT and DM Gash. Functional aspects of mammalian neural transplantation. CRC Crit
Rev. Neurobiol. 6:79-93,1991.
114. Gash, DM, JH Kordower, MS Fiandaca and JT Hansen. Adrenal medullary transplants in
primates. In: Intracerebral Transplantation in Movement Disorders (O Lindvall, A Bjorklund and
H Widner, Editors) Elsevier, Amsterdam, Restorative Neurol. 4:15-26, 1991.
115. Kurlan, R, MH Kim and DM Gash. Oral levodopa dose-response study in MPTP-induced
hemiparkinsonian monkeys: Assessment with a new rating scale for monkey parkinsonism.
Mov. Disord. 6:111-118, 1991.
116. Pearlman, SH., M Levivier, TJ Collier, JR Sladek Jr. and DM Gash. Striatal implants protect the
host striatum against quinolinic acid toxicity. Exp. Brain Res. 84:303-310, 1991.
117. Kurlan, R, MH Kim and DM Gash. The time course and magnitude of spontaneous recovery in
MPTP-induced parkinsonian monkeys. Ann. Neurol. 29:677-679, 1991.
118. Herman, JP, G J Thomas, SJ Wiegand and DM Gash. Lesions of parvocellular subdivisions of
the hypothalamic paraventricular nucleus: Effects on open field behavior and on performances
of memory-indicating tasks. Brain Res. 550:291-297, 1991.
119. Notter, MFD, M Kaniucki, SY Felten, JT Hansen and DM Gash. Effect of MPTP on primate
chromaffin cells in vitro : Relevance for adrenal medullary cell transplantation. Restorative
Neurol. Neurosci. 3:1-10, 1991.
120. Przedborski, S, M Levivier, V Kostic, V Jackson-Lewis, A Dollison, DM Gash, S Fahn and JL
Cadet. Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic
toxicity in rats: behavioral and morphological evidence. Brain Res. 550:231-238, 1991.
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121. Levivier, M, SH Pearlman, DM Gash and J Brotchi. Effet protecteur des greffes intrastriatales
dans un modele expérimental de maladie de Huntington. Corrélation comportementale et
morphologique. Neurochirurgie 37:148-159, 1991.
122. Klockgether, T, L Turski, T Honoré, ZM Zhang, DM Gash, R Kurlan and JT Greenamyre. The
AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and
MPTP-treated monkeys. Ann. Neurol. 30:717-723, 1991.
123. Greenamyre, JT, T Klockgether, L Turski, ZM Zhang, R Kurlan and DM Gash. Glutamate
receptor antagonism as a novel therapeutic approach in Parkinson's disease. In: Excitatory
Amino Acids (R Simon, Editor), Thieme Medical Publishers, New York, pp. 195-198, 1992.
124. Kordower, JH, DL Felten and DM Gash. Neural grafting for Parkinson's disease. In: The
Scientific Basis for the Treatment of Parkinson's Disease, (CW Olanow and AN Lieberman,
Editors), Parthenon Pub., Lancs, England, pp. 175-224, 1992.
125. Fiandaca, MS and DM Gash. New insights and technologies in brain grafting. Clin Neurosurg
39:482-508, 1992
126. Miller, RW, R Kurlan, JD Wyatt and DM Gash. A jejunal pouch technique in the Rhesus
monkey and related clinical observations. J. Med. Primatol. 21: 366-370, 1992.
127. Levivier, M, S Przedborski and DM Gash. Neurotrophic factors, intracerebral transplantation
and neuronal protection against excitotoxicity (letter). J. Neurosurg. 79:638-641, 1993.
128. Gash, DM. Book Review: Fetal tissue transplants in medicine.
329:513, 1993.
New Eng. J. of Medicine,
129. Smith, RD, ZM Zhang, R Kurlan, M McDermott and DM Gash. Developing a stable bilateral
model of parkinsonism in rhesus monkeys. Neurosci. 52:7-16, 1993.
130. Pearlman, S, M Levivier and DM Gash. Striatal implants of fetal striatum or gelfoam protect
against quinolinic acid lesions of the striatum. Brain Res. 613:203-211, 1993.
131. Gash, DM, M Bresjanac, F Junn and ZM Zhang. Trophic mechanisms mediating functional
recovery following intrastriatal implantation. In: Functional Neural Transplantation, (SB Dunnett
and A Bjorklund, Editors). Raven Press, Ltd., New York, pp. 139-156, 1994.
132. Junn, F, T Collier, S Felten and DM Gash. Rats with partial unilateral nigrostriatal lesions as a
model to study CNS plasticity. NeuroProtocols 4:168-176, 1994.
133. Hansen, JT, and DM Gash. Adrenal medulla in neural grafting and neural plasticity. Micro.
Research & Tech. 29: 155-160, 1994.
134. Coderre, J, P Rubin, A Freedman, JT Hansen, TS Wooding, D Joel and DM Gash. Selective
ablation of rat brain tumors by boron neutron-capture therapy. Int. J. Rad. Oncol. Biol. Phys.
28(5):1067-1077, 1994.
135. Sakai, K and DM Gash. Effect of a bilateral 6-OHDA lesion in the substantia nigra on locomotor
activity in the rat. Brain Res. 633:144-150, 1994.
136. Seigel, GM, F Junn, and DM Gash. Neurotrophic effects of amnion explants cocultured with rat
mesencephalon. Dev. Brain Res. 77:137-139, 1994.
137. Greenamyre, JT, RV Eller, ZM Zhang, A Ovadia, R Kurlan and DM Gash. Antiparkinsonian
effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of
Parkinson's disease. Ann. Neurol. 35:655-661, 1994.
138. Rubin, P, DM Gash, JT Hansen, DF Nelson and JP Williams. Disruption of the blood-brain
barrier as the primary effect of CNS irradiation. Radiotherapy & Onco. 31:51-60, 1994.
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139. Cass, WA, GA Gerhardt, ZM Zhang, A Ovadia and DM Gash. Increased dopamine clearance
in the non-lesioned striatum of rhesus monkeys with unilateral 1-methly-4phenyl-1,2,3,6tetrahydropyridine (MPTP) striatal lesions. Neurosci. Ltrs. 185:52-55, 1995.
140. Kearns, CM and DM Gash.
GDNF protects nigral dopamine neurons against 6hydroxydopamine in vivo. Brain Res. 672:104-111, 1995.
141. Levivier, M, DM Gash and S Przedborski. Time Course of the Neuroprotective Effect of
Transplantation on Quinolinic Acid-Induced Lesions of the Striatum. Neurosci. 69:43-50, 1995.
142. Ovadia, A, ZM Zhang and , DM Gash. Increased susceptibility to MPTP toxicity in middle-aged
rhesus monkeys. Neurobio. Aging 16:931-937, 1995.
143. Gerhardt, GA, WA Cass, M Henson, ZM Zhang, A Ovadia, BJ Hoffer and DM Gash. Agerelated changes in potassium-evoked overflow of dopamine in the striatum of the rhesus
monkey. Neurobio. Aging 16:939-946, 1995.
144. Gash, DM, ZM Zhang, WA Cass, A Ovadia, L Simmerman, D Martin, D Russell, F Collins, BJ
Hoffer and GA Gerhardt. Morphological and functional effects of intranigrally administered
GDNF in normal rhesus monkeys. J. Comp. Neurol. 363:345-358, 1995.
145. Gerhardt, GA, J Hudson, WA Cass, BJ Hoffer, ZM Zhang, A Ovadia, L Ketonen and DM Gash
In vivo electrochemical studies of dopamine overlow and clearance in normal and MPTPlesioned striatum of rhesus monkeys. J. Neurochem. 66:579-588, 1996.
146. Gash, DM, ZM Zhang, A Ovadia, WA Cass, A Yi, L Simmerman, D Russell, D Martin, P
Lapchak, F Collins, BJ Hoffer and GA Gerhardt. Functional recovery in parkinsonian monkeys
treated with GDNF. Nature 380:252-255, 1996.
147. Chen, Q, AH Andersen, ZM Zhang, A Ovadia, DM Gash and MJ Avison. Mapping drug-induced
changes in cerebral R2 * by multiple gradient recalled echo functional MRI. Mag. Res. Imag.
14:5:469-476, 1996.
148. Lapchak, PA, DM Gash, S Jiao, PJ Miller and D Hilt. Glial cell line-derived neurotrophic factor:
a novel therapeutic approach to treat motor dysfunction in Parkinson’s disease. Exp. Neurol.
144:29-34, 1997.
149. Lapchak, PA, DM Gash, F Collins, D Hilt, PJ Miller, and DM Araujo. Pharmacological activities
of glial cell line-derived neurotrophic factor (GDNF): preclinical development and application to
the treatment of Parkinson’s disease. Exp. Neurol. 145:309-321, 1997.
150. Miyoshi, Y, ZM Zhang, A Ovadia, P Lapchak, F Collins, D Hilt, C Lebel, R Kryscio and DM
Gash. GDNF-Levodopa interactions and reduction of side effects in parkinsonian monkeys.
Ann. Neurol. 42:208-214, 1997.
151. Bresjanac, M, J Sagen, G Seigel, C Paino, J Kordower and DM Gash. Xenogeneic adrenal
medulla graft-rejection rather than survival leads to increased rat striatal tryosine hydroxylase
immunoreactivity. J. Neuropath. Exp. Neurol. 56:490-498, 1997.
152. Zhang, ZM, Y Miyoshi, PA Lapchak, F Collins, D Hilt, C Lebel, R Kryscio and DM Gash. Dose
response to intraventricular GDNF administration in parkinsonian monkeys. J. Pharmacol. Exp.
Ther. 282:1396-1401, 1997.
153. Kearns, CM, WA Cass, K Smoot, R Kryscio, and DM Gash. GDNF protection against 6-OHDA:
Time dependence and requirement for protein synthesis. J. Neurosci. 17:7111-7118, 1997.
154. Cass, WA, C Kearns and DM Gash. Protective and regenerative properties of GDNF in the
central nervous system. In: Neuroprotective Signal Transduction (M Mattson, Editor) Humana
Press,Totowa, New Jersey 145-161, 1998.
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155. Gash, DM, GA Gerhardt and BJ Hoffer. Effects of GDNF on the nigrostriatal dopamine system
in rodents and nonhuman primates. Adv. Pharmacol. 42: 911-915, 1998.
156. Yurek, DM, SB Hipkens, MA Hebert, DM Gash and GA Gerhardt. Age-related decline in striatal
dopamine release and motoric function in brown Norway/Fischer 344 F1 hybrid rats. Brain Res
791:246-245, 1998.
157. Lapchak, PA, DM Araujo, DC Hilt, S Jiao, F Collins, Y Miyoshi, ZM Zhang and DM Gash.
Topographical distribution of [125I]- glial cell line -derived neurotrophic factor in unlesioned and
MPTP-lesioned rhesus monkey brain following a bolus intraventricular injection. Brain Res.
789:9-22, 1998.
158. Gash, DM, Z Zhang and GA Gerhardt. Neuroprotective and neurorestorative properties of
GDNF. Ann. Neurol. 44 (Suppl. 1):S121-125, 1998.
159. Grondin, R and DM Gash. Glial cell line-derived neurotrophic factor (GDNF): a drug for the
treatment of Parkinson's disease. J. Neurology 11(suppl. 3): P35-42, 1998.
160. Hoffman, AF, MA Hebert, BJ Hoffer, Z Zhang, WA Cass, DM Gash and GA Gerhardt.
Functional effects of GDNF on dopamine neurons in animal models of Parkinson's disease. In:
Progress in Alzheimer's and Parkinson's Diseases (Fisher et al., Eds) Plenum Press, New York,
1998.
161. Hebert, MA, BJ Hoffer, ZM Zhang, WA Cass, AF Hoffman, DM Gash and GA
Gerhardt.
Functional effects of GDNF in normal and parkinsonian rats and monkeys. for
(MH
Tuszynski, JH Kordower and K Bankiewicz, Editors) CNS Regeneration: Basic Science and
Clinical Applications Academic Press, San Diego, CA, 1999.
162. Zhang, ZM, M Zhang, C Avison, and DM Gash.
monkeys. Exp Neurol. 155:140-149, 1999.
MPTP-induced pallidal lesions in rhesus
163. Gerhardt, GA, WA Cass, P Huettl, S Brock, ZM Zhang and DM Gash. GDNF improves
dopamine function in the substantia nigra, but not the putamen of unilateral MPTP-lesioned
rhesus monkeys. Brain Res. 817:163-171, 1999.
164. Gash, DM, ZM Zhang, G Umberger, K Mahood, M Smith, C Smith and GA Gerhardt. An
automated movement analysis panel for upper limb motor functions in rhesus monkeys and
humans. J. Neurosci. Methods 89:111-117, 1999.
165. Smith, C, GH Umberger, EL Manning, JT Slevin, DR Wekstein, WR Markesbery, ZM Zhang, GA
Gerhardt and DM Gash. A critical decline in fine motor hand movements in human aging.
Neurology 53:1458-1461, 1999.
166. Andersen AH, DM Gash, and MJ Avison. Principal component analysis of the dynamic
response measured by fMRI: a generalized linear systems framework. Magn Reson. Imag. 17:
795-815, 1999
167. Andersen AH, ZM Zhang, M Zhang, DM Gash and MJ Avison. Age-associated changes in
rhesus CNS composition identified by MRI. Brain Res. 829: 90-98, 1999.
168. Chen, Q, AH Andersen, ZM Zhang, A Ovadia, WA Cass, DM Gash and MJ Avison. Functional
MRI of basal ganglia responsiveness to levodopa in parkinsonian rhesus monkeys. . Exp
Neurol. 158: 63-75, 1999.
169. Duan, Wenzhen, Z Zhang, DM Gash and Mark Mattson. Participation of Prostate Apoptosis
Response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease. Ann
Neurol. 46:587-597, 1999.
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170. Zhang, ZM, AH Andersen, MJ Avison, GA Gerhardt and DM Gash. Functional MRI of
apomorphine activation of the basal ganglia in awake rhesus monkeys. Brain Res. 852: 290296, 2000.
171. Zhang, Z, A Andersen, C Smith, R Grondin, GA Gerhardt and DM Gash. Motor slowing and
parkinsonian signs in aging rhesus monkeys mirror human aging. . J. Gerontology: Biol. Sci.
55A:B473-B480, 2000.
172. Grondin, R, Z Zhang, GA Gerhardt and DM Gash. Dopaminergic therapy improves upper limb
motor performance in aged rhesus monkeys. Ann Neurol 48: 250-253, 2000.
173. Grondin R, Z Zhang, D Elsberry, GA Gerhardt and DM Gash. Chronic intracerebral delivery of
trophic factors via a programmable pump as a treatment for parkinsonism. In: Parkinson's
Disease-Methods and Protocols (MM Mouradian, ed) Humana Press 62: 257-267, 2001.
174. Fox, C, DM Gash, K Smoot and WA Cass. Neuroprotective effects of GDNF against 6-OHDA
in young and aged rats. Brain Res. 896: 56-63, 2001.
175. Zhang, Z, AH Andersen, R Grondin, T Barber1, R Avison, GA Gerhardt and DM Gash.
Pharmacological MRI Mapping of Age-associated Changes in Basal Ganglia Circuitry of Awake
Rhesus Monkeys. NeuroImage 14: 1159-1167, 2001.
176. Maswood N and DM Gash. Biology of glial cell-line derived neurotrophic factor. In: The Role
of the TGF- Superfamily in Inflammation (SN Breit and S Wahl, eds) Birkhauser Publishing,
2002.
177. Gerhardt GA, WA Cass, A Yi, Z Zhang and DM Gash. Changes in somatodendritic but not
terminal dopamine regulation in aged rhesus monkeys. J Neurochem 80:168-177, 2002 .
178. Andersen AH, Z Zhang, T Barber, WS Rayens, JL Zhang, R Grondin, P Hardy, GA Gerhardt
and DM Gash. Functional MRI studies in awake rhesus monkeys: methodological and
analytical strategies. J Neurosci Meth 118:141-152, 2002.
179. Maswood N, R Grondin, Z Zhang, JA Stanford, SP Surgener, DM Gash and GA Gerhardt.
Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in
aged rhesus monkeys. Neurobiol. Aging 23:881-889, 2002 .
180. Grondin, R, Z Zhang, A Yi, N Maswood, WA Cass, W Markesbery, AH Andersen, DD Elsberry,
MC.Klein, GA Gerhardt and DM Gash. Chronic controlled GDNF infusion promotes structural
and behavioral recovery in advanced parkinsonian monkeys. Brain 125:2191-2201, 2002.
181. Andersen, A, Z Zhang, MJ Avison and DM Gash. Automated segmentation of multispectral
brain MR images. J Neurosci Meth 122:13-23, 2002.
182. Grondin R, Z Zhang, Y Ai, DM Gash and GA Gerhardt. Intracranial delivery of proteins and
peptides as a therapy for neurodegenerative diseases. In: Peptide Transport and Delivery into
the CNS. Birkhauser Verlag AG, (L. Prokai and K. Prokai-Tatrai, Editors) 61: 101-123, 2003.
183. Grondin R, WA Cass, Z Zhang, JA Stanford, DM Gash and GA Gerhardt. GDNF Infusion
Increases Motor Speed and Stimulus-Evoked Dopamine Release in Aged Rhesus Monkeys. J
Neurosci 23:1974-1980, 2003.
184. Ai Y, W Markesbery, Z Zhang, R Grondin, D Elseberry, GA Gerhardt and DM Gash.
Intraputamenal infusion in aging rhesus monkeys: distribution and dopaminergic effects. J
Comp Neurol 461:250-261, 2003.
185. Chen H-L, PM Lein, J-Y Wang, DM Gash, BJ Hoffer and J-H Chiang. Expression of bone
morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned
animals. Brain Res 994: 81-90, 2003.
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186. Salvatore MF, JL Zhang, DM Large, PE Wilson, CR Gash, TC Thomas, JW Haycock, G Bing,
JA Stanford, DM Gash, and GA Gerhardt. Striatal GDNF administration increases tyrosine
hydroxylase phosphorylation in the rat striatum and substantia nigra. J Neurochem. 90:245-54.,
2004.
187. Maswood N, J Young, E Tilmont, Z Zhang, DM Gash, GA Gerhardt, R Grondin, GS Roth, MA
Lane, R Carson, RM Cohen, PM Mouton, C Quiqley, MP Mattson, and DK Ingram. Calorie
restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral
deficits in a primate model of Parkinson’s disease. Proc Natl Acad Sci 101:18171-18176, 2004.
188. Smith CD, A Walton, AD Loveland, GH Umberger, RJ Kryscio and DM Gash. Memories that
last in old age: motor skill learning and memory preservation. Neurobiol Aging Jun;26(6):88390, 2005.
189. Slevin JT, GA Gerhardt, CD Smith, DM Gash, RJ Kryscio, and AB Young. Unilateral
intraputamenal GDNF improves bilateral motor functions in patients with Parkinson’s disease. J
Neurosurg. Feb;102(2):216-22, 2005.
190. Slevin JT, GA Gerhardt, CD Smith, DM Gash, RJ Kryscio, and AB Young. Letter to the Editor:
Research on Parkinson’s Disease. J Neurosurg Feb;102(2):401, 2005
191. Gash DM, Zhang Z, Ai Y, Grondin R, Coffey R, Gerhardt GA. Trophic factor distribution predicts
functional recovery in parkinsonian monkeys. Ann Neurol. 2005 Aug; 58(2):224-33.
192. Coffey R, J Slevin, G Gerhardt, B Schlutz and DM Gash. Commentary on “A crossroads in
GDNF therapy for Parkinson’s disease. A concensus conference report.” By Todd B. Sherer et
al. Ann Neurol. 2005
193. Chen Y, Ai Y, Slevin JR, Maley BE, Gash DM. Progenitor proliferation in the adult hippocampus
and substantia nigra induced by glial cell line-derived neurotrophic factor. Exp Neurol. 2005
Nov;196(1):87-95.
194. Hardy PA, Gash DM, Yokel R,Andersen A, Ai Y, Zhang Z. Correlation of R2 with total iron
concentration in the brains of rhesus monkeys. J Mag Res Imag 21:118-127, 2005
195. Zhang J, DM Stanton, ZV Nguyen, M Liu, Z Zhang, DM Gash, G Bing. Intrapallidal
lipopolysaccharide injection increases iron and ferritin levels in glia in the rat substantia nigra
and induces locomotor deficits. Neurosci 135:829-838 (2005).
196. Walton A, Branham A, Gash DM, Grondin R. Automated video analysis of age-related motor
deficits in monkeys using EthoVision. Neurobiol Aging 27:1477-1483 (2006)
197. Cass WA, Grondin R, Andersen AH, Zhang Z, Hardy PA, Hussey-Andersen LK, Rayens WS,
Gerhardt GA, Gash DM. Iron accumulation in the striatum predicts aging-related decline in
motor functions in rhesus monkeys. Neurobiol Aging Jan 25, 2006
198. Chebrolu H, Slevin JT, Gash DM, Gerhardt GA, Young B, Given CA, Smith CD. MRI volumetric
and intensity analysis of the cerebellum in Parkinson’s disease patients infused with glial
derived neurotrophic factor (GDNF). Exp Neurol. 198:450-456, 2006
199. Penn RD, Dalvi A, Slevin J, Young B, Gash DM, Gerhardt G, Hutchinson M. GDNF in treatment
of Parkinson’s disease: response to editorial. Lancet Neurol. 5:202-203, 2006
200. Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R,
Young AB. Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with
Parkinson’s disease:response to 1 year each of treatment and withdrawal. Neurosurgery Focus
May 15, 2006 20 (5)
HARD COPY VERSION APPEARED IN J Neurosurg 106: 614-620, 2007
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201. Slevin JT, Gerhardt GA, Smith CD, Gash DM, Young AB. Reply: GDNF poses troubling
questions for doctors, drug maker. Ann Neurol 59:989-990, 2006
202. Zhang Z, Andersen AH, Ai Y, Loveland A, Hardy PA, Gerhardt GA, Gash DM. Assessing
nigrostriatal dysfunction by pharmacological MRI in parkinsonian rhesus monkeys. NeuroImage
33:636-643, 2006
203. Salvatore M, Ai Y, Fischer B, Zhang A, Grondin R, Zhang Z, Gerhardt, GA, Gash DM. Point
source concentration of GDNF may explain failure of phase II clinical trial. Exp Neurol 202:497505, 2006
204. Stanford JA, Salvatore MF, Joyce BM, Zhang H, Gash DM, Gerhardt GA. Bilateral effects of
unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in
aged F344 rats. Neurobiol Aging. 28: 156-165 (2007).
205. Gash DM, Chen Y, Gerhardt GA. Neurotrophic factors and Parkinson’s Disease in (WC Koller
and E Melamed, Eds) Parkinson’s Disease and Related Disorders; Handbook of Clinical
Neurology, 3rd Ed pp 521-533, 2007
206. Smith CD, Walton A, Slevin JT, Gerhardt GA, Umberger G, Smoot K, Schultze E, Gash DM.
Validation studies of the human movement panel for hand/arm performance. J Neurosci
Methods Epub ahead of print June 22, 2007
207. Hovland DN, Boyd RB, Butt MT, Engelhardt JA, Moxness MS, Ma MH, Emery MG, Ernst NB,
Reed RP, Zeller JR, Gash DM, Masterman DM, Potter BM, Cosenza ME, Lightfoot, RM. Sixmonth continuous intraputamenal infusion toxicity study of recombinant methionyl Human Glial
Cell Line-Derived Neurotrophic Factor (r-metHuGDNF) in rhesus monkeys. Toxicologic
Pathology 35: 676-692, 2007
208. Quintero JE, Day BK, Zhang Z, Grondin R, Stephens ML, Huettl p, Pomerleau F, Gash DM,
Gerhardt GA. Amperometric measures of age-related changes in glutamate regulation in the
cortex of rhesus monkeys. Exp Neurol 208:238-246, 2007
209. Hunter RL, Choi DY, Kincer JF, Cass WA, Bing G, Gash DM. Fenbendazole treatment may
influence lipopolysaccharide effects in rat brain. Comp. Med. 57:487-492, 2007
210. Gash DM, Rutland K, Hudson NL, Sullivan PG, Bing G, Cass WA, Pandya JD, Liu M, Smith CD,
Slevin JT, Prince TS.
Trichloroethylene: Parkinsonism and Complex 1 Mitochondrial
Neurotoxicity. Ann Neurol. 63:184-192, 2008 (EPub ahead of print, Dec. 21, 2007).
211. Xin T, Ai Y, Gerhardt GA, Gash DM, Zhang Z. Globus pallidus plays a critical role in
neurotrophic factor induced functional improvements in hemiparkinsonian monkeys. Biochem
Biophys Res Commun. 370:434-9, 2008
212. Grondin R, Zhang Z, Ai Y, Ding F, Walton AA, Surgener SP, Gerhardt GA, Gash DM.
Intraputamenal infusion of exogenous neurturin protein restores motor and dopaminergic
function in the globus pallidus of MPTP-lesioned rhesus monkeys. Cell Transplant. 17: 373381, 2008
213. Luan L, Ding F, Ai Y, Andersen A, Hardy P, Forman E, Gerhardt GA, Gash DM, Grondin R,
Zhang Z. Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus
monkeys. Cell Transplant. 17: 417-425, 2008
214. Ding F, Luan L, Ai Y, Walton A, Gerhardt GA, Gash DM, Grondin R, Zhang Z. Development of
a stable, early stage unilateral model of Parkinson’s disease in middle-aged rhesus monkeys.
Exp. Neurol. 212:431-439, 2008
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Don M. Gash
215. Choi DY, Liu M, Hunter RL, Cass WA, Pandya JD, Sullivan PG, Shin EJ, Kim HC, Gash DM,
Bing G. Striatal neuroinflammation promotes parkinsonism in rats. PloS ONE 2009;
4(5):e5482.
216. Liu M, Choi DY, Hunter RL, Pandya JD, Cass WA, Sullivan PG, Kim HC, Gash DM, Bing G.
Trichloroethylene induces dopaminergic neurodegeneration in Fischer 344 rats. J Neurochem.
Epub Nov 17, 2009
217. Gash DM, Gerhardt GA, Slevin JT. GDNF (including Nurturin) In: Kompoliti K, and Verhagen
Metman L (eds.) Encyclopedia of Movement Disorders, vol. 1, pp534-537 Oxford: Academic
Press, 2010.
218. Bradley LH, Fuqua J, Richardson A, Turchan-Cholewo J, Ai Y, Kelps KA, Glass JD, He X,
Zhang Z, Grondin R, Littrel OM, Huettl P, Pomerleay F, Gash DM, Gerhardt GA. Dopamine
neuron stimulating actions of a GDNF propeptide. PLoS One March 18;5(3):e9752, 2010
219. Kelps KA, Turchan-Cholewo J, Hascup ER, Taylor TL, Gash DM, Gerhardt GA, Bradley LH.
Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from
the pro- and mature GDNF sequence. Neuropeptides. 45: 213-218, 2011
220. Stiles DK, Zhang Z, Ge P, Nelson B, Grondin R, Ai Y, Hardy P, Nelson PT, Guzaev AP, Butt
MT, Charisse K, Kosovrasti V, Tchangov L, Meys M, Maier M, Nechev L, Manoharan M,
Kaemmerer WF, Gwost D, Stewart GR, Gash DM, and Sah DWY. Widespread suppression of
huntingtin with convection-enhanced delivery of siRNA. Exp. Neurol. 233: 463-471 (2012)
221. Littrell OM, Fuqua JL, Richardson, AD, Turchan-Cholewo J, Hascup ER, Huettl P, Pomerleau F,
Bradley LH, Gash DM and Gerhardt, GA. A synthetic five amino-acid propeptide increases
neuron differentiation and neurochemical function. Neuropeptides 47: 43-49, 2013
222. Fuqua JL, Littrell OM, Lundblad M, Turchan-Cholewo J, Abdelmoti LG, Galperin E, Bradley LH,
Cass WA, Gash DM, Gerhardt GA. Dynamic changes in dopamine neuron function after
DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro. Peptides
54: 1-8 (2014) PMID: 24406899
BOOKS:
1.
2.
3.
JR Sladek, Jr. and DM Gash, Editors Neural Transplants: Development and Function. Plenum
Press, New York, 1984.
DM Gash and GJ Boer, Editors, Vasopressin: Principles and Properties, Plenum Press, New
York, 1987.
DM Gash and JR Sladek, Jr., Editors, Transplantation into the Mammalian CNS., (Progress in
Brain Research, volume 78) Elsevier, Amsterdam,: 1988.
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