Curriculum Vitae
Rhoda Au, PhD
ACADEMIC TRAINING:
1982 B.A.
Pomona College, Claremont, CA; Psychology
1985 Ph.D.
University of California, Riverside, Riverside, CA; Cognitive Psychology
Outstanding Dissertation – California Reading Association
1995 MBA
Boston University Boston MA; Management Policy/Org. Behavior
ACADEMIC APPOINTMENTS:
1985-1986
Research Associate, Boston VA Outpatient Clinic/Harvard School of Dental Medicine
1986-1989
Research Instructor of Neurology, Boston University School of Medicine
1989-2005
Research Assistant Professor of Neurology, Boston University School of Medicine
2005-2012
Associate Professor of Neurology, Boston University School of Medicine
2011-2012
Associate Professor, Ph.D. Program in Behavioral Neuroscience, Division of Graduate
Medical Sciences, BUSM.
2012Research Professor of Neurology, Boston University School of Medicine
2012Research Professor, Ph.D. Program in Behavioral Neuroscience, Division of Graduate
Medical Sciences, BUSM.
HONORS:
1984
1985
2010
Outstanding Teaching Assistant, University of California, Riverside
Constance McCullough Outstanding Dissertation, California Reading Association
Edith Kaplan Award, Massachusetts Neuropsychological Society
LICENSES AND CERTIFICATION:
1988-1994
Massachusetts License in Psychology
DEPARTMENT AND UNIVERSITY COMMITTEES:
2010 -
Neurobiology of Education, Dept. of Anatomy & Neurobiology, Boston University
School of Medicine
2011-
Steering Committee, Behavioral Neuroscience Ph.D. Program, Boston University School
of Medicine
TEACHING EXPERIENCE AND RESPONSIBILITIES:
1987-1988
Lecturer, University of Massachusetts, Boston, MA
1988-1990
Lecturer, Norfolk Prison Program, Boston University
1986-present
Regular guest lectures on Neuropsychology, Aging, Dementia in the Framingham Heart
Study – Boston VA Medical Center, Boston University Gerontology Summer program,
Boston University School of Public Health, Boston University School of Medicine,
Boston University, Department of Psychology
MAJOR ADMINISTRATIVE RESPONSIBILITIES:
1992-1993
Acting Deputy Director, Veterans Administration Medical Research, Washington DC
OTHER PROFESSIONAL ACTIVITIES:
PROFESSIONAL SOCIETIES: MEMBERSHIPS, OFFICES, AND COMMITTEE ASSIGNMENTS
2002-present
International Neuropsychological Society
Study Sections:
CV : Rhoda Au, Ph.D.
2009-current
2011
2/13/2016
2
Alzheimer’s Association scientific review
Chinese University of Hong Kong – Invited scientific review
OTHER PROFESSIONAL ACTIVITIES
2011Consortium for Epidemiologic Neuropsychological Data Analysis (CENDA) – a
consortium of neuropsychologists from University of California, San Diego, Drexel University,
University of Illinois, University of Utah, Lahey Clinic and Columbia University to focus on
Framingham’s unique qualitative neuropsychological data. Inaugural research retreat was held
in May 2011.
2009-
Expansion of FHS-China research collaborations - Co-PI with senior Framingham Heart
Study (FHS) investigators Emelia Benjamin, M.D. and Joanne Murabito, M.D. to create
China-based cohort study modeled after FHS.
OTHER COMMITTEE ASSIGNMENTS:
Research
2011 -
American Academy of Pediatrics/Committee on Adolescence (AAP/COA) Adolescent
Sleepiness Task Force (5 members) – preparing Technical Report for the journal
Pediatrics. Task Force is also creating AAP policy statement on school start times.
2010-
Advisor, Korean Genomic and Epidemiology Study, Korea University Medical Center,
Ansan, Korea
2007-
Consultant, NIA RO1 Brain Amyloid Deposition, Amyloid-β Peptides and Cognition in
Late Life Depression, Wendy Qui, PI, Department of Psychiatry, Boston University
(transferred from Tufts 12/09)
Private/Foundation
2007-current
2009-current
Advisory Board/Treasurer; WM Biassou Charitable Trust
Advisory Board; ViaCLIX, Los Gatos, CA
Current Other Support:
2 R01-NS17950 (Wolf)
NIH/NINDS
Precursors of Stroke Incidence and Prognosis $508,723
Role: Investigator
7/1/09-06/30/14
5 R01 AG08122 (Wolf/Seshadri)
NIH/NIA
Epidemiology of Dementia in the Framingham Study $631,824
Role: Investigator
6/1/05-05/31/16
R01-AG029451 (Murabito)
NIH/NIA
Exceptional Aging Across the Life Span: Framingham Study
Role: Investigator
05/01/08-04/30/12
1 R01 AG033040 (Wolf)
NIA/NINDS
MRI, Cognitive, Genetic & Biomarker Precursors of AD &
Dementia in Young Adults
$815,336
Role: Investigator
R01 AG 031287-A102 (Seshadri)
Neurotrophic Factors: Genetic Variation &
Serum Levels in Brain Aging
NIH/NIA
Role: Investigator
$499,906
08/01/09-07/31/11
1R01 NS062877-01 (PI: Morris, PI subcontract: Seshadri) NIH/NIA
Vitamin B12 & Folate in Relation to Cognition
in the Framingham Offspring Study
$84,968
01/15/09-12/31/13
Role: Investigator
04/01/09-03/31/11
CV : Rhoda Au, Ph.D.
1R21 TW008855 (Au/Abdullah)
Epidemiology of Mild Cognitive
Impairment and Dementia in China
2/13/2016
3
NIH/Fogarty/NIA
$100,000
Role: contact PI
6/17/10-5/31/12
Pending RO1 Applications:
R01-AG16495 (Wolf/Au)
NIH/NIA
MRI, Genetics and Cognitive Precursors of AD and Dementia
Role: joint PI
Past Other Support:
2 R01-NS17950 (Wolf)
NIH/NINDS
Precursors of Stroke Incidence and Prognosis
Role: Investigator
12/01/94-06/30/09
2 R01-AG16495 (Wolf)
NIH/NIA
MRI, Genetic and Cognitive Precursors of AD and Dementia
Role: Investigator
12/01/98-05/31/11
5 R01 AG08122 (Wolf)
NIH/NIA
Epidemiology of Dementia in the Framingham Study
Role: Investigator
10/1/90-05/31/05
5 R01 AA0133304-05 (Ellison)
NIH/NIAAA
Net Lifetime Health Effects of Alcohol Use and Abuse
Role: Neuropsychologist
05/16/03-04/30/08
VA Medical Research Grant
Language in the Aging Brain
Role: Investigator
2/86 -10/93
Invited Lectures and Presentations
1. Au, R., Obler, L., and Albert, M., Writing Disorders in Dementia, APA, New York City, August, 1987.
2. Au, R., Albert, M. and Obler, L., Language in Normal Aging: Linguistic and Neuropsychological Factors.
Journal of Neurolinguistics, 4, 1989.
3. Au, R., Obler, L., Joung, P. and Albert, M., Naming and Normal Aging: Age-Related Changes?, INS,
Orlando, Florida, February, 1990.
4. McNamara, P., Obler, L., Au R. and Albert M., Speech Monitoring and Speech Repair Processes in
Alzheimer's Disease and in Normal Aging, INS, Orlando, Florida, February, 1990.
5. McNamara, P., Obler, L., Au, R., Durso, R. and Albert, M., Language Specific Attentional Dysfunction
Underlies Anomia In Alzheimer's Disease, American Academy of Neurology, Miami, May, 1990.
6. Au, R. Study of Language in Aging, NYSSHLA, Kiamesha Lake, New York, April (symposium with
Loraine Obler and Martin Albert), 1990.
7. Au, R., Language in Normal Aging: A Decade of Research, APA, Boston, August (symposium with
Loraine Obler and Martin Albert), 1990.
8. Au, R., Obler, L., Albert, M., Birkner, S., and Van Breedem, L., Memory Influences on Discourse in
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Normal Aging, APA, Boston, August, 1990.
9. Au, R. and Obler L., Language in Healthy Aging, ASHA, Seattle, November, 1990.
10. Fitzpatrick, P., Obler, L.K., Au, R., Albert, M.L., and Nicholas, M., Visual Memory, Verbal Memory and
Age, INS, San Diego, February, 1992.
11. Kass, R., Au, R., Joung, P., Obler, L. and Albert, M.L., Longitudinal Naming Changes in Normal Aging,
Massachusetts Neuropsychological Society, Boston, June, 1992.
12. Au, R., Best, M., Obler, L.K., Jankowiak, J. and Albert, M.L., Naming and vocabulary in normal aging: A
prospective longitudinal study, INS, Galveston, February, 1993.
13. Au, R., Best, M., Obler, L.K. and Albert, M.L., Discourse and Naming in Normal Aging, INS, Galveston,
February, 1993.
14. McNulty K, Au R, White RF, Kelly-Hayes M, Kase CS, Wolf PA, Cobb J, D'Agostino RB. Cognitive
Profiles Following Stroke in the Framingham Study. JCEN. 1994; January.
15. Coo A, Au R, White RF, Cobb J, Wolf PA, D'Agostino RB. Age & Education Adjusted MMSE Norms in
the Framingham Study. JCEN 1994; January.
16. Seshadri S, Wolf PA, Beiser A, Au R, McNulty K, White R, D'Agostino RB. Lifetime Risk of Dementia
and Alzheimer's Disease: Estimates from the Framingham Study. Neurology 1996;46:A411.
17. Lin H-J, Wolf PA, Beiser AS, Kelly-Hayes M, Kase CS, Au R, White R. Incidence of Dementia after
Stroke: The Framingham Study. Neurology 1997;48:A283.
18. McNulty K, Au R, White RF, Myers R, Seshadri S, Knoefel J, Beiser A, D’Agostino RB, Wolf PA.
Estrogen Replacement Therapy in Association with Dementia in the Framingham Study. Journal of the
International Neurological Society 1997;3 (1):35.
19. McKee A, Seshadri S, Au R, Kase CS, Kowall N, Wolf PA. Cognitively Normal Very Elderly Brain
Donors in the Framingham Study Do Not Show Evidence of Definite Alzheimer’s Disease. Neurology
2000;54 (Suppl 3):A324.
20. Seshadri S, Wolf PA, Beiser A, Myers RH, Au R, D’Agostino RB. Smoking and the Risk of Alzheimer’s
Disease: Gender, Dose and Survival Modify Risks in the Framingham Study. Neurology 2000;54 (Suppl
3):A396.
21. DeCarli C, Beiser A, Seshadri S, D'Agostino RB, Kase CS , Au R, Kelly-Hayes M , Wolf PA.
Abnormalities of Cerebral White Matter and Stroke Risk in the Framingham Offspring Study. Stroke
2001;32:362.
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22. Seshadri S , Wolf PA , Beiser A, Elias MF, Au R, Kase CS, D'Agostino RB, DeCarli C. Stroke Risk Profile
Predicts Brain Volume and Cognitive Function in Stroke-free Subjects: The Framingham Study . Stroke
2001;32:321.
23. Young M, Au R, Massaro JM, Seshadri S, DeCarli C, Elias MF, White RF, D’Agostino R, Wolf PA. White
Matter Hyperintensity Volume Is Associated with Decreased Executive Functioning and Attention: The
Framingham Study. Neurology 2001;56 (Suppl 3):A107.
24. Jeerakathil TJ, Wolf PA, Au R, Aly AS, Kase CS, Massaro JM, DeCarli C. Gradient-Echo Cerebral
Microbleeds Predict Diminished Cognitive Function in a Community-Based Sample: The Framingham
Study. Stroke 2001;33;1:345.
25. Renda NC, McKee A, Au R, Massaro J, D’Agostino RB, Wolf PA, DeCarli C. Neuropathological
Correlates of Brain MRI in the Framingham Study. Neurology, 2002; 58 (Suppl 3):A133-134 (#P02.090).
26. Elias MF, D’Agostino RB, Sullivan LB, Elias PK, Seshadri S, Au R, Beiser A, Wolf PA. Risk of Stroke Is
Associated with Selective Cognitive Deficits: The Framingham Offspring Study. Asia Pacific Scientific
Forum, 42nd Annual Conference on Cardiovascular Epidemiology and Prevention. (Hawaii) April 2002. P314.
27. Tocco M, Au R, Beiser A, D’Agostino RB, Wolf, PA. The Effect of APO-4 in a Non-Demented Young
Elderly Population: The Framingham Study. The International Conference on Alzheimer’s Disease and
Related Disorders, Stockholm, Sweden. July 20-25, 2002.
28. Au R, Massaro J, Wolf P, Young M, D’Agostino R, DeCarli C. Global and Regional Brain Volumes Are
Related to Cognitive Function in Stroke and Dementia Free Subjects: The Framingham Study. The
International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden. July 20-25,
2002.
29. DeCarli C, Massaro J, Au R, D’Agostino R, Wolf PA. Cranial Cavity Size and Cognitive Performance
Amongst the Offspring of The Framingham Heart Study. The International Conference on Alzheimer’s
Disease and Related Disorders, Stockholm, Sweden. July 20-25, 2002.
30. Green RC, McKee A, Kowall N, Au R, Young M, Beiser A, Seshadri S, Auerbach S, Kase C, DeCarli C,
Wolf PA. Clinical Assessment of Alzheimer’s Disease: Sensitivity and Specificity in The Framingham
Study. The International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden.
July 20-25, 2002.
31. Beiser A, Au R, DeCarli C, Seshadri S, Elias M, Jacques P, D’Agostino RB, Wilson P, Selhub J, Rosenberg
I, Wolf PA. Higher Levels of Plasma Homocysteine Are Associated with Subsequent Lower Brain Volume
and Poorer Performance on Tests of Attention and Concentration: The Framingham Offspring Study. The
International Conference on Alzheimer’s Disease and Related Disorders, Stockholm, Sweden. July 20-25,
2002.
32. Au R, McKee A, Beiser A, Young M, D’Agostino R , Wolf P. Neocortical Neurofibrillary Changes
Associated with Memory Function in the Framingham Study. J Intl Neuropsych Soc 2003;9;2:175.
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33. Najarian RM, Seshadri S, Beiser A, Au R, Wolf PA. Blood Pressure, Weight Loss, and Alzheimer’s
Disease: Insights from the Framingham Study. Neurology 2003;60(Suppl 1):A207.
34. Auerbach SH, Au R, Beiser A, Seshadri S, Wolf PA. Mild Cognitive Impairment: 25 Year Follow-Up in
the Framingham Study. Neurology 2003;60(Suppl 1);A244.
35. Boyle PA, Au R, Beiser A, Kelly-Hayes M, Kase C, Wolf PA. Neuropsychological and Functional
Outcomes Following Stroke: Findings from the Framingham Study. Neurology 2003;60(Suppl 1);A191.
36. Seshadri S, Wolf PA, Beiser A, Au R, Wilson PWF, Selhub J, Jacques PF, Rosenberg IH, D’Agostino RB,
DeCarli C. Elevated Plasma Homocysteine Levels Are Associate with Subclinical Brain Injury in Healthy
Adults: Relation to Silent Cerebral Infarcts, White Matter Hyperintensity and MRI Brain Volume in the
Framingham Offspring. Neurology 2003;60(Suppl 1):A80.
37. Ivan CS, Beiser A, Seshadri S, Au R, Kase CS, Wolf PA. Dementia Following Stroke: Results from the
Framingham Study. Neurology 2003;60(Suppl 1);A78-79.
38. DeCarli C, Au R, Beiser A, Wolf PA. Differing Rates of Brain Change from Middle Age to Oldest-Old.
Neurology 2003;60(Suppl 1);A162.
39. Elias MF, Sullivan LM, D’Agostino RB, Elias PK, Au R, Selhub J, Wolf PA. Total Plasma Homocysteine
and Cognition: Framingham Offspring. J Inherit Metab Dis 2003; 26(Suppl 1);9.
40. Seshadri S, Beiser A, Vasan RS, DeCarli C, Wang TJ, Au R, Larson MG, Levy D, Wolf PA. Association of
Plasma Atrial and B-type Natriuretic Peptides in Silent Cerebral Infarcts and White Matter Hyperintensity
on Brain Magnetic Resonance Imaging. Stroke 2004;35;1:243 (P319).
41. Au R, Beiser A, Auerbach S, Wolf P. MCI - More Than Just Memory: Findings from the Framingham
Study. International Neuropsychological Society 32nd Annual Meeting Program, February 4-7, 2004, pg.
43. J Intl Neuropsych Soc, 2004.
42. Tocco M, Au R, Beiser A, Auerbach S, Wolf PA. Apo Plasma Levels and MCI: Findings from the
Framingham Heart Study. Neurology 2004;62 (Suppl 5):A209.
43. DeCarli C, Au R, Beiser A, Auerbach S, Wolf PA. Now You See It, Now You Don’t: How Definition
Affects the Biology of MCI in the Framingham Offspring Study. Neurology 2004;62 (Suppl 5):A237.
44. Au R, Beiser A, Cabral H, Auerbach S, Tocco MJ, Wolf PA. Defining amnestic MCI in the Framingham
Offspring Study. International Neuropsychological Society 33nd Annual Meeting Program, February 2-5,
2005, pg. 43. J Intl Neuropsych Soc, 2005. Published Online: 06 Apr 2005 Volume 11 – Issue S1 –
February 2005; pg.71.
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45. DeCarli C, Cabral H, Beiser A, Auerbach S, Wolf P, Au R. Conversion from Mild Cognitive Impairment
(MCI) to Dementia in the Framingham Heart Study: It Is More Than Memory. 57th Annual Meeting of the
American Academy of Neurology, Abstract S05.006. Neurology Mar2005;64;6(Suppl 1):A127
46. Wolf PA, Beiser A, Au R, Auerbach S, DeCarli C. Parental Occurrence of Dementia Linked to Lower
Cognitive Function in the Framingham Offspring Study. 57th Annual Meeting of the American Academy of
Neurology, Abstract #651835. Accepted. Neurology Mar2005;64;6(Suppl 1):A267-A268.
47. McKee A, Au R, Cabral H, Auerbach S, Green R, Kowall N, Wolf P. Microvascular lesions distinguish
cognitively impaired subjects without Alzheimer’s disease from unimpaired subjects: Findings from the
Framingham Heart Study. 2nd Congress of the International Society for Vascular Behavioural and
Cognitive Disorders (Vas-Cog 2005) Florence, Italy. Oral presentation June 8-12, 2005.
48. Akomolafe A, Besier A, Meigs J, Au R, Green RC, Wolf PA. Diabetes Mellitus and Risk of Developing
Alzheimer’s Dementia: Results from the Framingham Study. Poster accepted and presented at the
Alzheimer’s Association International Conference on Prevention of Dementia: Early Diagnosis and
Intervention, Marriott Wardman Park Hotel, Washington, D.C.; June 19th 2005.
49. Tocco M, Au R, Cabral H, Beiser A, Auerbach SH, Green RC, Wolf PA. Is ApoE Plasma Level Associated
with MCI? Findings from the Framingham Heart Study. Abstract presented at the Alzheimer's Association
International Conference on Prevention of Dementia; Early diagnosis and intervention; Marriott Wardman
Park Hotel, Washington, D.C.; June 18 - 21, 2005.
50. Au R, Beiser A, Wolf P, Seshadri S, DeCarli C. Stroke Risk Is Associated with Hippocampal Volume and
Cognition in the Framingham Heart Study. VAS-COG 2005, Florence, Italy. Abstract Book; Invited
Presentations, 2005:(P115):71.
51. Elias MF, Wolf PA, Sullivan LM, Seshadri S, Jacques PF, Elias PK, Au R, D’Agostino RB. Homocysteine
and Cognitive Decrement: the Framingham Studies. Clin Chem & Lab Med, 2005;(3);43.
52. Romero JR, Seshadri S, Beiser A, DeCarli C, Au R , Ramachandran V, Wolf PA. S45.005-Matrix
Metalloproteinases Are Associated with MRI Indices of Brain Ischemia and Aging: The Framingham Study.
Neurology, 2006;66(Suppl 2):A318.
53. DeStefano AL, Wolf PA, Seshadri S, Nguyen A-H, Massaro JM, Beiser A, Au R, DeCarli CD. P05.053Substantial Heritability of Total Brain and Temporal Lobe Volume in the Framingham Offspring Study.
Neurology, 2006;66(Suppl 2):A274.
54. Vitale S, Cabral H, DeCarli C, Seshadri S, Wolf PA, Au R. Decline in Mini-mental State Examination Is
Associated with Changes on Volumetric Brain MRI in the Framingham Offspring. JINS, 2006;12 (S1):145.
55. Jefferson AL, Massaro JM, Wolf PA, Au R, Seshadri SS, Ramachandran VS, Larson MG, Meigs J,
Kathiresan S, Keaney JF, Benjamin EJ, DeCarli C. O2-06-03: Inflammatory Biomarkers Are Associated
with Total Brain Volume: The Framingham Heart Study. Alzheimer’s & Dementia, 2006;2 (Suppl 1):S42S43.
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56. McKee AC, Au R, Cabral HJ, Kowall NW, Seshadri S, Kubilus CA, Drake J, Wolf PA. O1-01-08:
Pathological Evidence of Dense Alzheimer Lesions in the Visual Association Cortex of Cognitively Intact
Elderly Subjects. Alzheimer’s & Dementia, 2006;2 (Suppl 1):S10.
57. DeCarli C, Massaro J, Au R, Seshadri S, Wolf PA. P1-175: Stroke Risk Factors and Brain Atrophy Among
the Original Cohort of the Framingham Heart Study. Alzheimer’s & Dementia, 2006; 2 (Suppl 1):S147.
58. Tan ZS, Seshadri S, Beiser A, Roubenoff R, Dinarello C, Harris T, Benjamin E, Au R, Kiel DP, Vasan RS,
Wolf PA. P1-209: Relations of Serum Inflammatory Markers and Monocyte Production of Cytokines to the
Risk for Alzheimer’s Disease: The Framingham Study. Alzheimer’s & Dementia, 2006;2(Suppl 1):S157.
59. Bristow K, Au R, Massaro JM, Seshadri S, Wolf PA, Kelly-Hayes M, DeCarli C. Relationship of Silent
Cerebral Infarctions and White Matter Hyperintensities to Cognitive Performance in the Framingham
Offspring Study. Alzheimer’s Disease & Associated Disorders, July/September 2006; 20 (Suppl 2):S101.
60. Seshadri S, Massaro J, Manning WJ, Au R, Petrea RE, Beiser AS, Gona P, Jefferson AL, Benjamin EJ,
Vasan RS, D’Agostino Sr., RB, O=Donnell CJ, DeCarli C, Wolf PA. P188. Association of Aortic Plaque
Measures with Indices of Brain Aging on Volumetric Brain MRI in the Framingham Offspring Study.
Stroke, 2007;38:527.
61. Jefferson AL, Au R, Massaro JM, Seshadri S, Beiser A, Benjamin EJ, Gona P, Larson MG, O=Donnell C,
Wolf PA, Manning W. Aortic Plaque and Neuropsychological Functioning in the Framingham Heart Study.
International Neuropsychological Society, 35th Annual Meeting Program and Abstracts, Portland, OR,
February, 2007:238.
62. Blease SJ, Au R, Du Y, McKee A, Devine S, Rinn W, Denison H, O’Connor M, Beiser A, Cabral H,
Auerbach S, Seshadri S, Wolf P, Kaplan E. Relating Clock Drawing Performance and Alzheimer’s Disease
Pathology in the Framingham Heart Study. International Neuropsychological Society, 35th Annual Meeting
Program and Abstracts, Portland, OR, February, 2007:80.
63. Devine S, Rinn W, Denison H, O’Connor M, Au R, Wolf PA, Kaplan E. The Framingham Heart Study
Clock Scoring Protocol: An Introduction. International Neuropsychological Society, 35th Annual Meeting
Program and Abstracts, Portland, OR, February, 2007:33-34.
64. Au R, Beiser A, Seshadri S, Du Y, Cabral H, Auerbach S, DeCarli C, Wolf P. [S01.006] Structural Brain
Imaging Differentiates MCI Subtypes as Early as Middle Age: Results from the Framingham Offspring
Study. Neurology, 2007;68;(Suppl 1):A83-A84.
65. Palumbo CL, Beiser A, Au R, DeCarli C, Seshadri S, Wolf P. [P04.087] Apolipoprotein E Modifies the
Relationship of Brain MRI to Cognition: The Framingham Heart Study. Neurology, 2007;68;(Suppl
1):A166-A167.
66. Poly CK, Au R, Jacques P, Massaro J, Seshadri S, Wolf P. [P04.089] Dietary Choline Assessed by FoodFrequency Questionnaires in Relation to Cognitive Performance in the Framingham Offspring Cohort.
Neurology, 2007;68;(Suppl 1):A167.
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67. Seshadri S, Wolf PA, Beiser AS, DeCarli C, Au R, Levy D, Larson MG, Vasan RS, Benjamin ES, Mitchell
GF. [P04.092] Arterial Stiffness and Measures of Brain Aging on Volumetric MRI and on Cognitive
Testing: The Framingham Offspring Study. Neurology, 2007;68;(Suppl 1):A168.
68. Albert M, Au R, Massaro J, Seshadri S, Wolf P, DeCarli C. [P04.095] Sex Differences on Brain MRI and
Cognition in Framingham Offspring Study. Neurology, 2007;68;(Suppl 1):A168.
69. Seshadri S, DeStefano A, Au R, Massaro JM, Beiser A, Murabito JM, Kelly-Hayes M, D'Agostino RB,
DeCarli C, Wolf P, Atwood L. [PL01.002] Genetic Correlates of Brain Aging on MRI and Cognitive Test
Measures: Genome Wide Association Analyses in the Framingham Heart Study. Neurology, 2007;68;(Suppl
1):A183.
70. McKee AC, Drake JD, Lee HS, Kubilus CA, Wolf P, Au R, Kowall NW . [S21.005] Early Tau Alterations
Are Prominent in Posterior Association Cortex in Preclinical Alzheimer's Disease. Neurology,
2007;68;(Suppl 1):A189.
71. Paul CA, Au R, Fredman L, Massaro J, Seshadri S, Wolf P. [P05.030] The Effect of Alcohol Consumption
on Total Brain Volume: The Framingham Heart Study. Neurology, 2007;68;(Suppl 1):A224.
72. Romero JR, Seshadri S, Beiser A, Au R, Polak J, DeCarli C, Wolf PA. O-2. Carotid Artery
Atherosclerosis, MRI Indices of Brain Ischemia and Aging and Cognitive Impairment: The Framingham
Study. VAS-COG 2007 Program & Abstract Book, 2007:25.
73. Seshadri S, Beiser A, Au R, Kelly-Hayes M, Kase C, Wolf P. P-6. Mild Vascular Cognitive Impairment
Predicts Risk of Incident Stroke in the Framingham Study. VAS-COG 2007 Program & Abstract Book,
2007:40.
74. Jefferson AL, Massaro JM, Au R, Beiser A, Seshadri S, Larson MG, D’Agostino R, Lipinska I, Meigs JB,
Keaney JF, Kathiresan S, Vasan RS, Elias M, Wolf PA, Benjamin E. P-54. Inflammation and
Neuropsychological Functioning in the Framingham Heart Study. VAS-COG 2007 Program & Abstract
Book, 2007:52-53.
75. Stavitsky K, Du Y, Seichepine D, Laudate R, Beiser A, Au R, Seshadri S, DeCarli C, Wolf P. P-103.
White Matter Hyperintensity and Cognitive Functioning in the Ethnic Minority Cohort of the Framingham
Heart Study. VAS-COG 2007 Program & Abstract Book, 2007:66.
76. Wolf PA, Au R, Beiser A, Kase CS, Kelly-Hayes M. Precursors and Cerebrovascular Consequences of
Depressive Symptoms in a General Population: the Framingham Study. 46 th ACNP Annual Meeting, Boca
Raton, FL, Dec 19,2007.
77. Pikula A, Boger RH, Beiser A, Maas R, DeCarli C, Schwedhelm E, Du Y, Schulze F, Au R, Kelly-Hayes
M, Kase CS, Vasan RS, Wolf PA, Seshadri S. Plasma Asymmetric Dimethylarginine Levels are Associated
with Silent Cerebral Infarcts: The Framingham Study.
78. Laudate TM, Beiser A, Au R, Stavitsky K, Seichepine DR, Du Y, Seshadri S, Wolf PA, DeCarli C.L
Descriptive brain morphology in an ethnic minority sample: findings from the Omni Cohort of the
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Framingham Heart Study. Poster presentation during the Thirty-Sixth Annual International
Neuropsychological Society Conference, February 6-9, 2008 Waikoloa, Hawaii, USA Hilton Waikoloa
Village.
79. Au R. Epidemiology of Dementia: Framingham Heart Study. School of Public Health and Preventive
Medicine, Chinese University of Hong Kong, Hong Kong, January 18, 2009.
80. Au R. Framingham Heart Study: Epidemiology of Dementia and Preclinical Dementia Studies.
Department of Neurology, Peking Union Medical College, Beijing China, January 22, 2009.
81. Romero J, Beiser AS, Seshadri S, DeCarli C, Kase CS, Kelly-Hayes M, Au R, Wolf PA. Silent Cerebral
Infarction Incidence Exceeds that of Clinical Stroke in Mid-Life: The Framingham Heart Study.
International Stroke Conference San Diego, CA February 18-20, 2009.
82. Debette S, Beiser A, Au R, Auerbach S, DeCarli C, Wolf PA, Seshadri S. Parental dementia and Alzheimer
disease are associated with poorer memory in middle-aged adults: the Framingham Offspring Study. Plenary
sessions abstract submitted February 2009, for presentation during the 61st annual meeting of the American
Academy of Neurology in Seattle, April 25- May 2, 2009.
83. Debette S, Beiser A, DeCarli CD, Au R, Himali JJ, Kelly-Hayes M, Romero JR, Kase CS, Wolf PA,
Seshadri S. Association of MRI markers of vascular brain injury with mild cognitive impairment, incident
stroke and mortality: the Framingham Offspring Study. Abstract submitted February 2009 to be presented
during the International Conference of Alzheimer's disease (ICAD) conference on July 11-16, 2009 in
Vienna, Austria.
84. Romero JR, Beiser A, Seshadri S, Kase CS, Kelly-Hayes M, Au R, He J, Yoshita M, DeCarli C, Wolf PA.
Silent cerebral infarction incidence exceeds that of clinical stroke in mid-life: The Framingham Heart Study.
Poster presented at the International Stroke Conference, Feb. 17-20, 2009, San Diego Convention Center,
San Diego, CA. [Control/Tracking Number: 09-ISC-A-2153-AHA] Stroke; April 2009; 40(4):76 #P129
85. Lebowitz BK, Weinstein C, Beiser A, Seshadri S, Wolf PA, Au R. Relationship of suspected reading
disorder to prevalent MCI. Poster presentation at the Thirty-Seventh Annual Meeting International
Neuropsychological Society, February 11-14, 2009, Atlanta, Georgia, USA. JIN 2009:211.
86. Weinstein C, Lebowitz BK, Beiser A, Seshadri S, Wolf PA, Au R. Impact of Reading Impairment on MCI
Progression. Poster presentation at the Thirty-Seventh Annual Meeting International Neuropsychological
Society, February 11-14, 2009, Atlanta, Georgia, USA. JIN 2009:210-211
87. Kawadler J, Au R, Pekkala S, Wiener D, Obler L, McKee A, Auerbach S, Seshadri S, Wolf P. Can
Language Performance Differentiate the Pre-Clinical Stages of Alzheimer's Disease: Findings from the
Framingham Heart Study. Journal of the International Neuropsychological Society, 37th Annual Meeting
Program and Abstracts, Atlanta, GA, February, 2009:15(Suppl S1): pp i-249.
88. Pikula A, Beiser A, Himali JJ, Debette S, DeCarli C, Au R, Selhub J, Tofler G, Wang TJ, Kelly-Hayes M,
Kase CS, Benjamin EJ, Vasan RS, Wolf PA, Romero JR, Seshadri S. Multiple Biomarkers and Risk of
Clinical and Subclinical Brain Injury. The Framingham Heart Study. Oral presentation at the International
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Stroke Conference. The conference is scheduled from Wednesday, February 24 - Friday, February 26, 2010
at the Henry B. Gonzalez Convention Center, San Antonio, TX
89. Aung K, Himali J, Beiser A, Rowbothham R, Devine S, Kaplam E, Seshadri S, Wolf PA, Au R.
Relationship between Framingham Stroke Risk Profile, Brain Imaging and Clock Drawing Performance.
38th Annual Meeting, International Neuropsychological Society, February 3-6, 2010, Acapulco, Mexico.
90. Au R. The Framingham Heart Study: Neurological studies. Invited address; Pulmonary Division, Korea
University Medical Center, Ansan, Korea. January 1-2, 2010.
91. Au R. The reality of changing school start times. Invited address: National Sleep Foundation, National
Harbor, MD, March 5-6,2010.
92. Au R. The pre-clinical stage of Alzheimer’s Disease: A 30-year prospective study of the Framingham
Cohort. Invited address: 8th Annual Symposium on Early Alzheimer’s Disease. Mount Sinai Medical
Center, Miami Beach, FL. March 12-13, 2010.
93. Tan ZS, Beiser AS, Au R, Kelly-Hayes M, Vasan RS, Auerbach S, Murabito J, Pikula A, Wolf PA,
Seshadri S. Physical Activity and the Risk of Dementia: The Framingham Study. ICAD 2010.
94. Ahl R, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Defining MCI in the Framingham Heart Study
Offspring: Education vs. WRAT-based norms. Presented at the INS conference, February 2-5, 2011 in
Boston, MA.
95. Amble C, Beiser A, Seshadri S, Himali J, Wolf PA, Decarli C, Au R. Impact of Physical Activity on Brain
Aging: Framingham Offspring Study. Presented at the INS conference, February 2-5, 2011 in Boston, MA.
96. Au R. Implementing qualitative scoring of neuropsychological tests in a community-based cohort:
Framingham Heart. Presented at the INS conference, February 2-5, 2011 in Boston, MA.
97. Au R. Using Qualitative Neuropsychological Measures in an Epidemiologic Study: The Framingham
Offspring Cohort. Presented at the INS conference, February 2-5, 2011 in Boston, MA.
98. Draxler Hankee L, Beiser A, Rosner Preis S, Devine S, Seshadri S, Wolf PA, Au R. Distribution of
qualitative performance on executive functioning tasks: Results from the Framingham Offspring Cohort.
Presented at the INS conference, February 2-5, 2011 in Boston, MA.
99. Gupta A, Beiser A, Rosner Preis, Devine S, Draxler Hankee L, Seshadri S, Wolf PA, Au R. The
Association between Cardiovascular Risk Factors and Qualitative Measures of Trails B: Framingham
Offspring Study. Presented at the INS conference, February 2-5, 2011 in Boston, MA.
100. Nishtala A, Beiser A, Rosner Preis S, Devine S, Draxler Hanke L, Seshadri S, Wolf PA, Au R.
Relationship of Cardiovascular Risk and Qualitative Measures of Executive Function in the Framingham
Offspring Study. Presented at the INS conference, February 2-5, 2011 in Boston, MA.
101. Nyborn J, Himali J, Beiser A, Devine S, Du Y, Kaplan E, O’Connor MK, Rinn W, Denison H, Seshadri
S, Wolf PA, Au R. Framingham Heart Study Clock Drawing Performance 2005-2008: Normative Data
from the Offspring Cohort. Presented at the INS conference, February 2-5, 2011 in Boston, MA. To be
published in J. of International Neuropsy. Society.
102. Pekkala S, Wiener D, Au R, Himali J, Beiser A, Seshadri S, McKee A, Auerbach S, Wolf PA, Obler LK.
Lexical Symptoms of Alzheimer’s Disease a Decade Prior to Death. Presented at the INS conference,
February 2-5, 2011 in Boston, MA. To be published in J. of International Neuropsy. Society.
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103. Driver JA, Beiser AS, Kurth T, Au R, Seshadri S, Wolf PA. [S44.001] Cancer and Reduced Risk of
Alzheimer's Disease: The Framingham Heart Study. Session S44: Aging and Dementia: Risk Factors AAN,
April 9–16, 2011 in Honolulu, HI.
104. Karakis I, Beiser A, Booth S, Jacques P, Rogers G, Au R, DeCarli C, Wolf PA, Wang T, Seshadri S. Serum
Vitamin D Concentrations and Subclinical Indices of Brain Aging: The Framingham Offspring Study.
AAN, April 9–16, 2011 in Honolulu, HI.
105. Pikula A, Beiser A, Chen T, Vorgias D, DeCarli C, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Seshadri S.
Serum BDNF Alters Risk of Stroke and MRI Vascular Brain Injury: The Framingham Study. Accepted to
AAN, April 9–16, 2011 in Honolulu, HI.
106. Romero JR, Beiser A, Preis SR, DeCarli C, Young Lee D, Pikula A, Au R, Wang J, Kase C, Wolf PA,
Benjamin E, Fontes J, Irizarry M, Seshadri S. [P02.209] Lipoprotein Associated Phospholipase A2 (LpPLA2) and Cerebral Microbleeds: The Framingham Heart Study. AAN, April 9–16, 2011 in Honolulu, HI.
107. Miller, I.N., Himali, J.J., Beiser A, Murabito JM, Seshadri S, Wolf PA, & Au, R. (2011). Cardiovascular
predictors of cognitive health in the oldest-old: The Framingham study. 64th Annual Scientific Meeting of
the Gerontological Society of America, Boston, MA.
108. Miller, I.N., Himali, J.J., Beiser A, Murabito JM, Seshadri S, Wolf PA, & Au, R. (2011). Normative data for
the cognitively intact oldest-old: Data from the Framingham study. 64th Annual Scientific Meeting of the
Gerontological Society of America, Boston, MA.
109. Au R. Epidemiology of Stroke: Framingham Heart Study. Department of Neurology, Peking Union
Medical College, Beijing, China, January 6, 2012.
110. Au R. Framingham Heart Study Dementia Study: 30 years of evolution. Department of Oncology, Peking
Union Medical College, Bejing, China, January 7, 2012.
111. Au R. Framingham Heart Study Dementia Project: Framingham and China. Sichuan University Medical
School, Chengdu, China, January 9, 2012.
112. Weinstein G, Beiser A, Au R, DeCarli C, Wolf PA, Seshadri S. Association of Parental Stroke with
Cognitive and Brain MRI Measures in Offspring - The Framingham Heart Study. [Abstract #3069].
Presented at the International Stroke Conference, February 1-3, 2012 in New Orleans, LO.
113. Appleman ER, Stavisky K, Au R. Impact of School Start Time Changes on Sleep Patterns in Elementary
through High School Age Students. National Sleep Foundation, 2012. March 2-3, Washington D.C.
114. Cann A, Appleman ER, Stavitsky K, Au R. The Effects of Health Comorbidities on Sleep Duration in
School-Aged Children. National Sleep Foundation, 2012. March 2-3, Washington D.C.
115. Kim S, Appleman ER, Stavitsky K, Au R. The Impact of Parenting Styles on Children’s Sleep Duration.
National Sleep Foundation, 2012. March 2-3, Washington D.C.
116. Homsi M, Appleman ER, Stavitsky K, Au R. The effect of parent opinion on responses to a survey on the
change of school start times. National Sleep Foundation, 2012. March 2-3, Washington D.C.
117. Monge Z, Appleman ER, Stavitsky K, Au R. The Effects of Caffeine on Sleep Duration in Young Children
and Adolescents. National Sleep Foundation, 2012. March 2-3, Washington D.C.
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118. Camargo E, Beiser A, Tan ZS, Au R, DeCarli C, Pikula A, Kelly-Hayes M, Kase CS, Wolf PA, Seshadri S.
Walking Speed, Handgrip Strength and Risk of Dementia and Stroke: The Framingham Offspring Study. To
be presented at the American Academy of Neurology meeting, April 21-28, 2012 in New Orleans, LO.
Bibliography: insert all authors in order and use full citations
ORIGINAL, PEER REVIEWED ARTICLES:
1. Au R, Albert ML, Obler LK. The relation of aphasia to dementia. Aphasiology 1988;2(2):161-173.
2. Au R, Albert ML, Obler LK. Reply: Language in dementia: Agreement? Aphasiology 1988;2 (2):199.
3. Au R. Cognitive cloud: Thunderheads on the horizon? Aphasiology 1989;3(8):751-753.
4. Au R, Albert ML, Obler LK. Language in normal aging: Linguistic and neurospychological factors.
Journal of Neurolinguistics 1989;4.
5. McNamara P, Obler LK, Au R, Durso R, Albert ML. Speech monitoring skills in Alzheimer's disease,
Parkinson's disease, and normal aging. Brain Lang 1992;42(1):38-51.
6. Au R, Joung P, Nicholas M, Obler L, Kass R, Albert M. Naming ability across the adult lifespan. Aging
and Cognition 1995;2:300-311.
7. Cobb JL, Wolf PA, Au R, White R, D'Agostino RB. The effect of education on the incidence of dementia
and Alzheimer's Disease in the Framingham Study. Neurology 1995;45(9):1707-1712.
8. Nicholas M, Obler LK, Au R, Albert ML. On the nature of naming errors in aging and dementia: a study of
semantic relatedness. Brain and Language 1996;54(2):184-195.
9. Myers RH, Schaefer EJ, Wilson PW, D'Agostino R, Ordovas JM, Espino A, Au R, White RF, Knoefel JE,
Cobb JL, McNulty KA, Beiser A, Wolf PA. Apolipoprotein E epsilon4 association with dementia in a
population-based study: The Framingham Study. Neurology 1996;46(3):673-677.
10. Seshadri S, Wolf PA, Beiser A, Au R, McNulty K, White R, D'Agostino RB. Lifetime risk of dementia and
Alzheimer's Disease. The impact of mortality on risk estimates in the Framingham Study. Neurology
1997;49(6):1498-1504.
11. Ramsay CB, Nicholas M, Au R, Obler LK, Albert ML. Verb naming in normal aging. Appl Neuropsychol
1999;6(2):57-67.
12. Elias MF, Beiser A, Wolf PA, Au R, White RF, D'Agostino RB. The preclinical phase of alzheimer disease:
A 22-year prospective study of the Framingham Cohort. Arch Neurol 2000;57(6):808-813.
13. Elias MF, Beiser A, Wolf PA, Au R, White RF, D'Agostino RB. 22 Years of prospective study of the
preclinical phase of Alzheimer's Disease: The Framingham Cohort: Research and Practice in Alzheimer's
Disease 2001;5:50-56.
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14. Elias MF, Sullivan LM, D’Agostino RB, Elias PK, Beiser A, Au R, Seshadri S, DeCarli C, Wolf PA. The
Framingham stroke risk profile and lowered cognitive performance. Stroke 2004, 35;404-409.
15. Massaro JM, D’Agostino RB, Sullivan LM, Beiser A, DeCarli C, Au R, Elias MF, Wolf PA. Managing and
analysing data from a large-scale study on Framingham Offspring relating brain structure to cognitive
function. Statist Med 2004;23:351-367.
16. Au R, Wolf PA, Beiser A, Seshadri S. New norms for a new generation: cognitive performance in the
Framingham Offspring Cohort. Experimental Aging Research, 2004;30:333-358.
17. Ivan CS, Seshadri S, Beiser A, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Dementia after stroke: the
Framingham Study. Stroke 2004; 35(6):1264-1268.
18. Jeerakathil T, Wolf PA, Beiser A, Hald JK, Au R, Kase CS, Massaro JM, DeCarli C. Cerebral microbleeds.
prevalence and associations with cardiovascular risk factors in the Framingham Study. Stroke
2004;35(8):1831-1835.
19. Seshadri S, Beiser A, Ivan CS, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Response: Does preventing
stroke prevent all kinds of dementia? Response to Stroke 2004;35;11;2436-2437. Stroke 2004.
20. Seshadri S, Wolf PA, Beiser A, Elias MF, Au R, Kase CS, D'Agostino RB, DeCarli C. Stroke risk profile,
brain volume, and cognitive function: the Framingham Offspring Study. Neurology 2004 Nov 9;63(9):15919.
21. Tan ZS, Seshadri S, Beiser A, Zhang Y, Felson D, Hannan MT, Au R, Wolf PA, Kiel DP. Bone mineral
density and the risk of Alzheimer disease. Arch Neurol 2005; 62(1):107-111.
22. DeCarli C, Harvey D, Hald J, Tullberg M., Massaro J, Au R, Beiser A, Wolf PA. Measures of brain
morphology and infarction in the Framingham Heart Study: Establishing What Is Normal. Neurobiology of
Aging, 2005;26(4):491-510.
23. Elias MF, Sullivan LM, D’Agostino RB, Elias PK, Jacques PF, Selhub J, Seshadri S, Au R, Beiser A, Wolf
PA. Homocysteine and cognitive performance in the Framingham Offspring Study: age is important. Am J
Epidemiol 2005;162 (7):644-653.
24. Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Au R, Kannel WB, Wolf PA. The lifetime risk of stroke:
estimates from the Framingham Study. Stroke 2006 Feb;37(2):345-50. Epub 2006 Jan 5.
25. DeStefano AL, Atwood LD, Massaro JM, Heard-Costa N, Beiser A, Au R, Wolf PA, DeCarli C. Genomewide scan for white matter hyperintensity: the Framingham Heart Study. Stroke 2006 Jan;37(1):77-81.
26. Au R, Massaro JM, Wolf PA, Young ME, Beiser A, Seshadri S, D’Agostino RB, DeCarli C. Association of
white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study.
Arch Neurol Feb2006;63(2):246-250.
27. Najarian RM, Seshadri S, Beiser A, Au R, Wolf PA. Metabolic syndrome compared with type 2 diabetes
mellitus as a risk factor for stroke: the Framingham Offspring Study. Arch Intern Med 2006 Jan
9;166(1):106-11.
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28. McKee, AC, Au R, Cabral HJ, Kowall NW, Seshadri, S, Kubilus C, Drake J, Wolf P. Visual association
pathology in preclinical Alzheimer Disease. Journal Neuropath Exp Neurol 2006;65(6):621-630.
29. Elias MF, Sullivan LM, Elias PK, Vasan RS, D'Agostino RB, Seshadri S, Au R, Wolf PA, Benjamin EJ.
Atrial fibrillation is associated with lower cognitive performance in the Framingham Offspring Men. The
Journal of Stroke and Cerebrovascular Diseases. (Sept-Oct) 2006;15(5):214-222.
30. Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S: Diabetes mellitus
and risk of developing Alzheimer's dementia: results from the Framingham Study. Arch Neurol 2006;
63:1551-1555.
31. Schaefer EJ, Bongard V, Beiser AS, Lamon-Fava S, Robins SJ, Au R, Tucker KL, Kyle DJ, Wilson PWF,
Wolf PA. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer
disease. The Framingham Heart Study. Arch Neurol. Nov2006;63(11):1545-1550.
32. Elias MF, Sullivan LM, Elias PK, D'Agostino Sr RB, Wolf PA, Seshadri S, Au R, Benjamin EJ, Vasan RS.
Left Ventricular Mass, Blood Pressure, and Lowered Cognitive Performance in the Framingham Offspring.
Hypertension. 2007 Mar;49(3):439-45. Epub 2007 Jan 15. PMID: 17224472
33. Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA Harris TB, Benjamin EJ, Au R, Kiel DP, Wolf
PA, Seshadri S. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study.
Neurology. 2007 May 29;68(22):1902-8. PMID: 17536046
34. Wolf PA, Beiser A, Elias MF, Au R, Vasan RS, Seshadri S. Relation of obesity to cognitive function:
importance of central obesity and synergistic influence of concomitant hypertension. The Framingham
Heart Study. Cur Alzheimer Res, 2007;4;2: 111-116. PMID: 17430232
35. Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan RS, Larson MG, Meigs JB, Keaney JF Jr,
Lipinska I, Kathiresan S, Benjamin EJ, DeCarli C. Inflammatory biomarkers are associated with total brain
volume: The Framingham Heart Study. Neurology 2007; 68: 1032-1038. PMID: 17389308
36. Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, Kelly-Hayes M, Kase CS, D'Agostino RB Sr,
DeCarli C, Atwood LD, Wolf PA: Genetic correlates of brain aging on MRI and cognitive test measures: a
genome-wide association and linkage analysis in the Framingham Study. BMC Med Genet 2007; 8(Suppl
1):S15 http://www.biomedcentral.com/1471-2350/8/S1/S15.
37. Sun X, Steffens DC, Au R, Folstein M, Summergrad P, Yee J, Rosenberg I, Mwamburi DM, Qiu WQ.
Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch Gen Psychiatry. 2008
May;65(5):542-50. PMID: 18458206
38. Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, Yoshita M, Rosenberg IH, D'Agostino RB,
DeCarli C. Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes,
white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the
Framingham Offspring Study. Arch Neurol. 2008 May;65(5):642-9. PMID: 18474741
39. Paul CA, Au R, Fredman L, Massaro JM, Seshadri S, DeCarli C, Wolf PA. Association of alcohol
consumption with brain volume in the Framingham study. Arch Neurol. 2008 Oct;65(10):1363-7. PMID:
18852353
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40. Tan ZS, Beiser A, Vasan RS, Au R, Auerbach S, Kiel DP, Wolf PA, Seshadri S. Thyroid function and the
risk of Alzheimer disease: the Framingham Study. Arch Intern Med. 2008 Jul 28;168(14):1514-20. PMID:
18663163
41. Debette S, Wolf PA, Beiser A, Au R, Himali JJ, Pikula A, Auerbach S, DeCarli C, Seshadri S: Association
of parental dementia with cognitive and brain MRI measures in middle-aged adults. Neurology
2009;73:2071-2078. PMID:20007524. PMC2790222. Debette S, Bis JC, Fornage M, Schmidt H, Ikram
MA, Sigurdsson S, Heiss G, Struchalin M, Smith AV, van der Lugt A, DeCarli C, Lumley T, Knopman
DS, Enzinger C, Eiriksdottir G, Koudstaal PJ, DeStefano AL, Psaty BM, Dufouil C, Catellier DJ, Fazekas
F, Aspelund T, Aulchenko YS, Beiser A,Rotter JI, Tzourio C, Shibata DK, Tscherner M, Harris
TB, Rivadeneira F, Atwood LD, Rice K, Gottesman RF, van Buchem MA, Uitterlinden AG, Kelly-Hayes
M, Cushman M, Zhu Y, Boerwinkle E, Gudnason V, Hofman A, Romero JR, Lopez O, van Duijn CM, Au
R, Heckbert SR, Wolf PA, Mosley TH,Seshadri S, Breteler MM, Schmidt R, Launer LJ, Longstreth WT Jr.
Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE
Consortium. STROKE. 2010 Feb;41(2):210-7. Epub 2009 Dec 31. PMID: 20044523. NIHMS167015.
42. DeStefano AL, Seshadri S, Beiser A, Atwood LD, Massaro JM, Au R, Wolf PA, DeCarli C: Bivariate
heritability of total and regional brain volumes: the Framingham Study. Alzheimer Dis Assoc Disord
2009;23:218-223. PMID:19812462. PMC2760008.
43. Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, Roubenoff R, Auerbach S, DeCarli C, Wolf PA,
Seshadri S: Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain
aging. JAMA 2009;302:2565-2572. PMID:20009056. NIHMS180013.
44. Pikula A, Boger RH, Beiser AS, Maas R, DeCarli C, Schwedhelm E, Himali JJ, Schulze F, Au R, KellyHayes M, Kase CS, Vasan RS, Wolf PA, Seshadri S: Association of plasma ADMA levels with MRI
markers of vascular brain injury: Framingham offspring study. Stroke 2009;40:2959-2964.
PMID:19644064. PMC2749945.
45. Romero JR, Beiser A, Seshadri S, Benjamin EJ, Polak JF, Vasan RS, Au R, DeCarli C, Wolf PA: Carotid
artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham
study. Stroke 2009;40:1590-1596. PM:19265054. PMC2705324.
46. Romero JR, Vasan RS, Beiser AS, Au R, Benjamin EJ, DeCarli C, Wolf PA, Seshadri S: Association of
matrix metalloproteinases with MRI indices of brain ischemia and aging. Neurobiol Aging 2009.
PMID:19128858. NIHMS126979.
47. Debette S, Beiser A, DeCarli CD, Au R, Himali JJ, Kelly-Hayes M, Romero JR, Kase CS, Wolf PA,
Seshadri S. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive
impairment, dementia and mortality: the Framingham Offspring Study. Stroke. 2010 Feb 18. [Epub ahead
of print]. PMID: 20167919. NIHMS181227.
48. Debette S, Wolf PA, Beiser A, Au R, Himali JJ, Pikula A, Auerbach S, DeCarli C, Seshadri S. Association
of Parental Dementia with Cognitive and Brain MRI Measures in Middle-Aged Adults. Neurology 2009;
73: 2071-2078. PMID: 20007524.
49. Zade D, Beiser A, McGlinchey R, Au R, Seshadri S, Palumbo C, Wolf PA, DeCarli C, Milberg W.
Interactive Effects of apoE4 Genotype and Cerebrovascular Risk on Neuropsychological Performance and
Structural Brain Changes." has been accepted for publication in Journal of Stroke and Cerebrovascular
Diseases. 2010 Jul-Aug;19(4):261-8.
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50. Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Bis JC, Smith AV, Carassquillo MM,
Lambert JC, Harold D, Schrijvers EM, Debette S, Longstreth WT, Janssens C, Pankratz S, Dartigues JF,
Hollinhworth P, Aspelund T, Beiser A, Kuller LH, Koudstaal PJ, Dickson DW, Tzourio C, Abraham R, Du
Y, Rotter JI, Aulchenko YS, Harris TB, Petersen RC, Berr C, Owen MJ, Varadarajan BN, Becker JT,
Rivadeneira F, Nalls MA, Graff-Radford NR, Campion D, Auerbach S, Rice K, Hofman A, Jonsson PV,
Schmidt H, Lathrop M, Mosley TH, Au R, Psaty BM, Uitterlinden AG, Farrer LA, Lumley T, Williams J,
Amouyel P, Younkin SG, Wolf PA, Launer LJ, Lopez O, van Duijn CM, Breteler MMB. Genome-wide
Association Studies of Alzheimer's Disease. Lancet. In press.
51. Albert M, Massaro J, DeCarli C, Beiser A, Seshadri S, Wolf PA, Au R. Profiles by sex of brain MRI and
cognitive function in the Framingham offspring study. Alzheimer Dis Assoc Disord. 2010 AprJun;24(2):190-3. [PMID:20505436]. PMCID: PMC2879078
52. Stavitsky K, Du Y, Seichepine D, Laudate TM, Beiser A, Seshadri S, DeCarli C, Wolf PA, Au R. White
matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham
heart study. Neuroepidemiology. 35:117-122, 2010.
53. Saczynski JS, Beiser AS, Seshadri S, Auerbach S, Wolf PA, Au R. Depressive symptoms and risk of
dementia: The Framingham Heart Study. Neurology. 2010 Jul 6;75(1):35-41.
54. Jefferson AL, Himali JJ, Beiser A, Au R, Massaro JM, Seshadri S, Gona P, Salton CJ, DeCarli C,
O’Donnell CJ, Benjamin EJ, Wolf PA, Manning WJ. Cardiac index is associated with brain aging: The
Framingham Heart Study. Circulation. 2010 Aug 17;122(7):690-7.
55. Debette S, Beiser A, Hoffmann U, Decarli C, O'Donnell CJ, Massaro JM, Au R, Himali JJ, Wolf PA, Fox
CS, Seshadri S. Visceral fat is associated with lower brain volume in healthy middle-aged adults. Ann
Neurol. 2010 Aug; 68(2):136-44.
56. Seshadri S, Beiser A, Au R, Wolf PA, Evans DA, Wilson RS, Petersen RC, Knopman DS, Rocca WA,
Kawas CH, Corrada MM, Plassman BL, Langa KM, Chui HC. Operationalizing diagnostic criteria for
Alzheimer's disease and other age-related cognitive impairment-Part 2. Alzheimers Dement. 2011 Jan;
7(1):35-52.
57. Tan ZS, Beiser AS, Fox CS, Au R, Himali JJ, Debette S, Decarli C, Vasan RS, Wolf PA, Seshadri S.
Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive
markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study. Diabetes Care.
2011 Aug;34(8):1766-70.
58. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium.
Fornage M, Debette S, Bis JC, Schmidt H, Ikram MA, Dufouil C, Sigurdsson S, Lumley T, DeStefano AL,
Fazekas F, Vrooman HA, Shibata DK, Maillard P, Zijdenbos A, Smith AV, Gudnason H, de Boer R,
Cushman M, Mazoyer B, Heiss G, Vernooij MW, Enzinger C, Glazer NL, Beiser A, Knopman DS,
Cavalieri M, Niessen WJ, Harris TB, Petrovic K, Lopez OL, Au R, Lambert JC, Hofman A, Gottesman RF,
Garcia M, Heckbert SR, Atwood LD, Catellier DJ, Uitterlinden AG, Yang Q, Smith NL, Aspelund T,
Romero JR, Rice K, Taylor KD, Nalls MA, Rotter JI, Sharrett R, van Duijn CM, Amouyel P, Wolf PA,
Gudnason V, van der Lugt A, Boerwinkle E, Psaty BM, Seshadri S, Tzourio C, Breteler MM, Mosley TH,
Schmidt R, Longstreth WT, DeCarli C, Launer LJ. Ann Neurol. 2011 Jun;69(6):928-39.
59. Jefferson AL, Massaro JM, Beiser AS, Seshadri S, Larson MG, Wolf PA, Au R, Benjamin EJ.
Inflammatory Markers and Neuropsychological Functioning: The Framingham Heart Study.
Neuroepidemiology. 2011 Jul 13;37(1):21-30
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60. Debette S, Seshadri S, Beiser A, Au R, Himali JJ, Palumbo C, Wolf PA, Decarli C. Midlife vascular risk
factor exposure accelerates structural brain aging and cognitive decline. Neurology. 2011 Aug 2;77(5):4618.
61. Zade D, Beiser A, McGlinchey R, Au R, Seshadri S, Palumbo C, Wolf PA, Decarli C, Milberg W..
Apolipoprotein Epsilon 4 Allele Modifies Waist-to-Hip Ratio Effects on Cognition and Brain Structure. J
Stroke Cerebrovasc Dis. 2011 Aug 9.
62. Au R. Brain aging in the graying population: Not all the same color. Neurology. 2011 Aug 23;77(8):706707.
63. Poly C, Massaro JM. Seshadri S, Wolf PA, Cho E, Kaye E, Jacques PF, Au R. The Relationship of Dietary
Choline to Cognitive Performance and White Matter Hyperintensity in the Framingham Offspring Cohort.
American Journal of Clinical Nutrition, 2011 Dec; 94(6):1584-91.
64. Tan ZS, Harris WS, Beiser AS, Au R, Himali JJ, Debette S, Pikula A, Decarli C, Wolf PA, Vasan RS,
Robins SJ, Seshadri S. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging.
Neurology. 2012 Feb 28;78(9):658-64. PMID: 22371413. PMCID: PMC3286229.
65. van Himbergen TM, Beiser AS, Ai M, Seshadri S, Otokozawa S, Au R, Thongtang N, Wolf PA, Schaefer
EJ. Biomarkers for Insulin Resistance and Inflammation and the Risk for All-Cause Dementia and
Alzheimer Disease: Results From the Framingham Heart Study. Arch Neurol. 2012 Jan 2. PMID: 22213409.
NIHMSID: NIHMS351799.
66. Driver JA, Beiser A, Au R, Seshadri S, Wolf PA, Kreger B, Splansky GL, Kurth T. The link between
cancer and Alzheimer’s Disease: Results from the Framingham Study. BMJ. 2012 March: 344.
67. Nyborn JA, Himali JJ, Beiser AS, Devine SA, Du R, Kaplan E, O’Connor MK, Rinn, WE, Denison HS,
Seshadri S, Wolf PA, Au R. The Framingham Heart Study Clock Drawing Performance: Normative Data
from the Offspring cohort. Experimental Aging Research, In press.
68. Au R, Seshadri S, Knox K, Beiser A, Himali JJ, Cabral HJ, Auerbach S, Green RC, Wolf PA, McKee A.
The Framingham Brain Donation Program: Neuropathology of Cognitively Normal Aging, Mild Cognitive
Impairment, Dementia and Alzheimer’s Disease. Current Alzheimer’s Research, In press.
CASE REPORTS, REVIEWS, CHAPTERS AND EDITORIALS
Textbook Chapters:
1. Singer H, Au R, Dreher MJ, Nolte RY, Rogers-Zegarra N, Simonsen S, Yopp HK.Research on reading
through the grades with practical applications for improvement of classroom practice. In: M. Douglass (ed.)
Writing and Reading Across the Curriculum. Claremont Graduate School. 1985.
2. Au R, Bowles N. Memory influences on language in normal aging. In: D Ripich (ed), Handbook of
Geriatric Communication Disorders, College Hill Press, San Diego, CA, 1990
3. Au R, Obler LK, Albert ML. Language in aging and dementia. In: M Sarno (ed.), Acquired Aphasia,
(Second Edition), Academic Press, San Diego. 1991.
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2/13/2016
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4. White RF, Au R, Durso R, Moss MB. Neuropsychological function in Parkinson's disease. In Clinical
Syndromes in Adult Neuropsychology: The Practitioner¹s Handbook, edited by R.F. White, Elsevier
Science Publishers B.V., 1992; 253-286.
5. Melvold J, Au R, Obler LK, Albert ML. Language in aging and dementia. In M.L. Albert and J. Knoefel,
Eds., Clinical Neurology of Aging, 1994, NY:Oxford.
6. Obler LK, Au R, Albert ML. Language and aging. In R. Huntley and K. Helfer, Eds., Communication in
Later Life, Butterworth Heinemann, Newton, MA, 1995;85-98.
7. Au R, Albert M, Obler L. The relation of aphasia to dementia. Aphasiology 1998, reprinted in C. Code and
D. Muller, Eds., Forums in Clinical Psychology, 1995; London, Whurr Publishers.
8. Nicholas, N., Ramsay, C., Obler, L.K., Au, R., and Albert, M.L., Naming in Normal Aging and Dementia of
the Alzheimer's Type. In H. Goodglass and A. Wingfield, Eds., Anomia: The Neuroanatomical and
Cognitive Correlates of Name-Finding Failure Following Focal Brain Lesion, Orlando, FL: Academic
Press, 1998, 166-191.
9. Barresi B, Obler LK, Au R, Albert ML. Language-related factors influencing naming in adulthood. In H.
Hamilton, Ed., Old Age and Language: Multidisciplinary Perspectives, Garland, 1998.
10. Elias MF, Beiser A, Wolf PA, Au R, White RF, D'Agostino RB. 22 Years of Prospective Study of the
Preclinical Phase of Alzheimer's Disease: The Framingham Cohort. Research and Practice in Alzheimer's
Disease, Vol 5., Editors: Vellas, Feldman, Grundman, Fitten, Biacobini, Winblad. Serdi Publisher (Paris),
Springer Publishing Co (New York). 2001, Section II - Mild Cognitive Impairment, pp. 50-56.
11. Libon DJ, Delano-Wood L, Bondi MW, Au R. Mild Cognitive Impairment: A Heterogeneous
Neuropsychological Disorder. Encyclopedia of Neurological Sciences, 2nd edition. Edited by Aminoff and
Daroff. Elsevier Press.
12. Au R, Devine S. Implementing the Boston Process Approach in the Framingham Heart Study: It is
Possible. The Boston Process Approach to Neuropsychological Assessment: A Practitioner’s Guide. Edited
by Lee Ashendorf and David Libon. Oxford University Press.
13. Au, R., Appleman E, Stavisky K. Systematic Strategies: Case of School Start Times. The Oxford
Handbook of Infant, Child, and Adolescent Sleep: Development and Problems. Edited by Wolfson and
Montgomery-Downs. Oxford University Press.