2006 – San Diego
ImToxSS Member in Bold
Practical Strategies for Evaluation of Immunosuppression in Pharmaceutical Development
- CE
Chair: Brian G. Short
Speakers:
Kenneth L. Hastings – Immunotoxicology: What’s new on the ICH Harmonization Front?
Patrick J. Haley – Immunosuppression Signal Detection in Standard Toxicity Studies and
Immunophenotyping: A Pathologist’s Approach
J. Herzyk – Assay to Assay: Functional Evaluation of Immunosuppression
Ian Gourley – Clinical Viewpoint: Interpretation of Non-Clinical Immunotoxicity
Regulatory Application of the Mouse LLNA: New Challenges and Opportunities –
Workshop
Chair: Michael Woolhiser and Greg Ladics
Speakers:
G.S. Ladics and M.R. Woolhiser – Regulatory Application of the Mouse LLNA: New Challenges and
Opportunities
I. Kimber – Performance and Validation of the Local Lymph Node Assay
A. Cockshott – Regulatory Experience of Testing New, Industrial Chemicals with the LLNA
A. Jacobs – Considerations for Pharmaceutical Products and the Local Lymph Node Assay (LLNA)
G. Gerberick – Application of LLNA Data in Skin Sensitization Risk Assessment
M.R. Woolhiser - LLNA Experience for Complex Chemistries and Mixtures
Immunotoxicity Evaluation by Immune Function Tests – Workshop
Chair: Danuta Herzyk and Michael Holsapple
Speakers:
D.J. Herzyk – Immunotoxicity Evaluation by Immune Function Tests
G. Ladics – Primary Immune Response to Sheep Red Blood Cells (SRBC) as the Conventional TDAR
Test
K. White – Comparison of Primary Immune Responses to SRBC and KLH in Rodents
P. Bugelski – TDAR Tests: Meta-analysis of Results Generated Across Multiple Laboratories
H. Haggerty – Immunotoxicity Testing in Non-Rodent Species
Indirect Mechanisms of Toxicity: Advancing our Understanding of NeuroendocrineImmune Interactions –
Symposium
Chair: Leigh Ann Burns Naas and Virginia M. Sanders
Speakers:
L. Burns Naas and V.M. Sanders - Indirect Mechanisms of Toxicity: Advancing our Understanding of
Neuroendocrine-Immune Interactions
V.M. Sanders – Non-Immune Mechanisms for Regulating the Level of Immunity
S.B. Pruett, C. Schwab, R. Fan, P. Myers, Q. Zheng – Modeling and Predicting the Immunological
Effects of Chemical and Drug Induced Stress Responses in Mice
G.D. Marshall – Impact of Psychological and Environmental Factors on Asthma: From Environment to
Bench to Bedside
D.A. Lawrence, et al. – Children’s Health Risk-Can Economic Inequalities Impact the Neuroimmune
Interface and Health?
The War on Ozone in the 3rd Millennium: Toxicology and Health Effects Update –
Symposium
Chair: Deepak Bhalla and W. M. Foster
Speakers:
D.K. Bhalla and M.W. Foster - The War on Ozone in the 3rd Millennium: Toxicology and Health
Effects Update
J.S. Ultman, et al. – Where Does Inhaled Ozone Go?
C.G. Plopper – Early Postnatal Lung Development is Highly susceptible to Permanent Disruption by
Oxidant Stress from Ozone Exposure
D.K. Bhalla – Inflammatory Mechanisms in Ozone induced Mucosal Injury in the Lung
W.M. Foster – Lessons Learned from Laboratory Exposure of Humans to Ozone: Differential
Susceptibility
I.B. Tager – Human Health Effects of Ambient Ozone: Epidemiological and Physiological Perspective
Models and Mechanisms of Occupational/Environmental Asthma – Symposium
Chair: Jean Regal and Mike Luster
Speakers:
M.I. Luster and J.F. Regal - Models and Mechanisms of Occupational/Environmental Asthma
D.I. Bernstein – Pathogenesis of Occupational Asthma
V.J. Johnson and M.I. Luster – Using Murine Models to Understand the Immunologic Basis of Toluene
Diisocyanate Asthma
J.F. Regal, et al. – Differential Gene Expression and Effector Mechanisms in Murine Models of
Trimellitic Anhydride and Ovalbumin-Induced Asthma
A.E. Nel – The Role of Oxidative Stress in the Exacerbation of Asthma by Particulate Air Pollution
S.R. Kleeberger – Genetic Susceptibility and Ozone Exacerbation of Allergic Asthma
The Bases for Inter-Individual Differences for Susceptibility to Allergic Disease –
Symposium
Chair: Ian Kimber and Frank Gerberick
Speakers:
I. Kimber and F. Gerberick – The Bases for Inter-Individual Differences for Susceptibility to Allergic
Disease
I. Kimber – Chemical and Protein Allergy: Immunological Mechanisms and Clinical Characteristics
G. Gerberick – Heritable and Acquired Factors Influencing Susceptibility to Allergic Contact Dermatitis
S.M. Tarlo – Heritable and Acquired Factors Influencing Susceptibility to Chemical Respiratory Allergy
B. Nemery and I. Kimber – Chemical Pollution, Genetic Factors and the Changing Prevalence of Atopic
Allergy and Asthma
R.J. Dearman and I. Kimber – Factors Governing the Acquisition of Food Allergy