DACARBAZINE
RTECS NUMBER
: NI3950000
CHEMICAL NAME
: Imidazole-4-carboxamide,
5-(3,3-dimethyl-1-triazeno)CAS REGISTRY NUMBER
: 4342-03-4
LAST UPDATED
: 199904
DATA ITEMS CITED
: 46
MOLECULAR FORMULA
: C6-H10-N6-O
MOLECULAR WEIGHT
: 182.22
WISWESSER LINE NOTATION : T5M CNJ DVZ ENUNN1&1
COMPOUND DESCRIPTOR
: Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Biocarbazine R
* Dacarbazine
* Deticene
* (Dimethyltriazeno)imidazolecarboxamide
* 4-(Dimethyltriazeno)imidazole-5-carboxamide
* 4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide
* 4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide
* 5-(Dimethyltriazeno)imidazole-4-carboxamide
* 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide
* 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
* DTIC-dome
* 1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)* NCI-C04717
* NSC-45388
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human
DOSE/DURATION
: 3500 ug/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Blood - leukopenia
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC)
V.52(6)-59,
1968-75. For publisher information, see CTRRDO.
Volume(issue)/page/year:
57,83,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 2147 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - antipsychotic
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 9,3105,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.11949Volume(issue)/page/year: 50,306,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 411 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - antipsychotic
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 9,3105,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2032 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - antipsychotic
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 9,3105,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 567 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87.
For
publisher information, see JNCIEQ. Volume(issue)/page/year: 62,721,1978
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 466 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - antipsychotic
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 9,3105,1981
TYPE OF TEST
: LD10 - Lethal Dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JSONAU Journal of Surgical Oncology. (Alan R. Liss, Inc., 41 E. 11th
St.,
New York, NY 10003) V.11969- Volume(issue)/page/year: 15,355,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1568 mg/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87.
For
publisher information, see JNCIEQ. Volume(issue)/page/year: 62,693,1978
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1730 mg/kg/15W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
Skin and Appendages - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
54,951,1975
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
25 mg/kg
female 20 day(s) after conception
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.11949Volume(issue)/page/year: 50,306,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3900 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
Skin and Appendages - tumors
REFERENCE :
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11965Volume(issue)/page/year: 52,1,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1950 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11965Volume(issue)/page/year: 52,1,1975
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3700 mg/kg/14W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
Skin and Appendages - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 11,73,1970
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
50 mg/kg
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,2231,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,
NY
10003) V.11906/08- Volume(issue)/page/year: 186,461,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,2231,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 400 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,2231,1973
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,467,1982
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 ug/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,467,1982
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 600 pg/plate
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies
in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,
Calcutta
700 019, India) V.11958- Volume(issue)/page/year: 28,159,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 500 umol/L/3D
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
202,251,1988
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
204,239,1988
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 10 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
24,615,1975
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 100 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
24,615,1975
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: DNA damage
: Intraperitoneal
: Rodent - rat
DOSE/DURATION
: 6 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 12,285,1991
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 37500 ug/kg
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
21,2817,1972
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
36,2827,1976
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
36,2827,1976
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 225 mg/kg/48H (Intermittent)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
389,3,1997
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 75 mg/L
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 1,277,1978
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 9 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
223,259,1989
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 9 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
223,259,1989
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 75 mg/L
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 1,277,1978
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 200 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,577,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 20 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,467,1982
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 400 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,577,1983
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 26,203,1981
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 26,203,1981
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,184,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3246
No. of Facilities: 412 (estimated)
No. of Industries: 1
No. of Occupations: 9
No. of Employees: 17273 (estimated)
No. of Female Employees: 12863 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
NCI Carcinogenesis Studies (ipr);clear evidence:mouse,rat
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11965Volume(issue)/page/year: 52,1,1975
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
DDD
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
KI0700000
Ethane, 1,1-dichloro-2,2-bis(p-chlorophenyl)72-54-8
1914072
4-05-00-01884 (Beilstein Handbook Reference)
199904
24
C14-H10-Cl4
320.04
GYGYR DG&R DG
Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzene, 1,1'-(2,2-dichloroethylidene)bis(4-chloro* 1,1-Bis(p-chlorophenyl)-2,2-dichloroethane
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
1,1-Bis(4-chlorophenyl)-2,2-dichloroethane
2,2-Bis(p-chlorophenyl)-1,1-dichloroethane
2,2-Bis(4-chlorophenyl)-1,1-dichloroethane
DDD
p,p'-Ddd
1,1-Dichloor-2,2-bis(4-chloor fenyl)-ethaan
1,1-Dichlor-2,2-bis(4-chlor-phenyl)-aethan
1,1-Dichloro-2,2-bis(p-chlorophenyl)ethane
1,1-Dichloro-2,2-bis(4-chlorophenyl)-ethane
1,1-Dichloro-2,2-bis(parachlorophenyl)ethane
1,1-Dichloro-2,2-di(4-chlorophenyl)ethane
Dichlorodiphenyl dichloroethane
p,p'-Dichlorodiphenyldichloroethane
1,1-Dicloro-2,2-bis(4-cloro-fenil)-etano
Dilene
ENT 4,225
ME-1700
NCI-C00475
OMS 1078
RCRA waste number U060
Rhothane
Rhothane D-3
Rothane
TDE
p,p'-TDE
Tetrachlorodiphenylethane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 113 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information
Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year:
6,154,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 88,400,1946
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - convulsions or effect on seizure threshold
Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the
United States. (Denver, CO) V.3-38, 1939-74. Volume(issue)/page/year:
16,3,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LBASAE Laboratory Animal Science. (American Assoc. for Laboratory Animal
Science, 210 N. Hammes Ave., Suite 205, Joliet, IL 60435) V.211971Volume(issue)/page/year: 26,274,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 504 mg/kg/6W-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Immunological Including Allergic - decrease in
Immunological Including Allergic - decrease in
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology.
Information
Directorate, CSIR, Hillside Rd., New Delhi 110
Volume(issue)/page/year: 34,517,1996
toxic dose
cellular immune response
humoral immune response
(Publications &
012, India)
V.1-
1963-
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 54 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-131,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - mouse
DOSE/DURATION
: 39 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
52,883,1974
(Washington, DC)
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 10 ug/L
REFERENCE :
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed.,
New
York, Plenum Pub. Corp., 1976 Volume(issue)/page/year: -,555,1976
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 28400 nmol/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
54,981,1975
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Bacteria - Serratia marcescens
DOSE/DURATION
: 1500 mg/kg
REFERENCE :
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946,
Leipzig
DDR-7010, Ger. Dem. Rep.) V.11881- Volume(issue)/page/year:
91,311,1972
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 5,83,1974
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,179,1991
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,179,1991
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,179,1991
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5013
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 14 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/182171/AS
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-nonhuman;
Host-mediated assay
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);clear evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-131,1978
NCI Carcinogenesis Bioassay (feed);no evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-131,1978
DDE
RTECS NUMBER
CHEMICAL NAME
: KV9454000
: Ethylene,
1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)CAS REGISTRY NUMBER
: 3424-82-6
BEILSTEIN REFERENCE NO. : 1977640
REFERENCE
: 4-05-00-02177 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C14-H8-Cl4
MOLECULAR WEIGHT
: 318.02
WISWESSER LINE NOTATION : GYGUYR DG&R BG
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)* o,p'-DDE
* 2,4'-DDE
* Ethylene, 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloro*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 880 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB85-143766
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 10 ug/L
REFERENCE :
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed.,
New
York, Plenum Pub. Corp., 1976 Volume(issue)/page/year: -,555,1976
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman
DDT
RTECS NUMBER
CHEMICAL NAME
: KJ3325000
: Ethane, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
50-29-3
1882657
4-05-00-01885 (Beilstein Handbook Reference)
199907
202
C14-H9-Cl5
354.48
GXGGYR DG&R DG
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aavero-extra
* Agritan
* Arkotine
* Azotox
* Benzene, 1,1'-(2,2,2-trichloroethylidene)bis(4-chloro* Benzochloryl
* alpha,alpha-Bis(p-chlorophenyl)-beta,beta,beta-trichlorethane
* 1,1-Bis-(p-chlorophenyl)-2,2,2-trichloroethane
* 2,2-Bis(p-chlorophenyl)-1,1,1-trichloroethane
* Bosan Supra
* Bovidermol
* Chlorophenothan
* Chlorophenothane
* Chlorophenotoxum
* Citox
* Clofenotane
* DDT
* DDT
* Azotox M 33
* Deoval
* Detox
* Detoxan
* Dibovin
* Dichlorodiphenyltrichloroethane
* Dichlorodiphenyltrichloroethane
* p,p'-Dichlorodiphenyltrichloroethane
* 4,4'-Dichlorodiphenyltrichloroethane
* Dicophane
* Dodat
* Dykol
* ENT 1,506
* Estonate
* Gesafid
* Gesarol
* Hildit
* Ivoran
* Mutoxan
* NCI-C00464
* Neocid
* Neocidol (solid)
* OMS 16
* Parachlorocidum
* PEB1
*
*
*
*
*
*
*
*
*
*
*
Pentachlorin
RCRA waste number U061
Santobane
Tafidex
1,1,1-Trichloor-2,2-bis(4-chloor fenyl)-ethaan
1,1,1-Trichlor-2,2-bis(4-chlor-phenyl)-aethan
Trichlorobis(4-chlorophenyl)ethane
1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane
1,1,1-Trichloro-2,2-di(4-chlorophenyl)-ethane
1,1,1-Tricloro-2,2-bis(4-cloro-fenil)-etano
Zerdane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
2,845,1945
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Behavioral - headache
Gastrointestinal - nausea or vomiting
Skin and Appendages - sweating
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 16 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Oral
Human
500 mg/kg
Behavioral - convulsions or effect on seizure threshold
Cardiac - arrhythmias (including changes in conduction)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and
Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
Volume(issue)/page/year:
11,446,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - analgesia
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
2,268,1947
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 221 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 87 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept.,
Midland, MI 48640) V.11945- Volume(issue)/page/year: 35,25,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1931 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,14,1978
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam,
Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year:
17,351,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
1,865,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(10),27,1972
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 12,368,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam,
Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year:
17,351,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 32,463,1981
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 86,213,1946
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AVPCAQ Advances in Pharmacology and Chemotherapy. (Academic Press, Inc.,
1
E. First St., Duluth, MN 55802)
Volume(issue)/page/year:
12,31,1975
V.7-20, 1969-84.
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 86,213,1946
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Behavioral - tremor
:
:
:
:
V.1-
LDLo - Lowest published lethal dose
Oral
Mammal - cat
250 mg/kg
1909/10-
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 86,213,1946
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 86,213,1946
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,347,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
1,865,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
1,865,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 86,213,1946
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 7,159,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
1,865,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
1,865,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LBASAE Laboratory Animal Science. (American Assoc. for Laboratory Animal
Science, 210 N. Hammes Ave., Suite 205, Joliet, IL 60435) V.211971Volume(issue)/page/year: 26,274,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEMOAQ Medizinische Monatsschrift. (Stuttgart, Fed. Rep. Ger.) V.1-31,
1947-77. Volume(issue)/page/year: 4,25,1950
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 7600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ENVPAF Environmental Pollution. (Barking, UK) V.1-20, 1970-79.
Volume(issue)/page/year: 20,45,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 24100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 74,343,1947
V.4-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - domestic
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEMOAQ Medizinische Monatsschrift. (Stuttgart, Fed. Rep. Ger.) V.1-31,
1947-77. Volume(issue)/page/year: 4,25,1950
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Unreported
: Mammal - species unspecified
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 17(3),32,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 336 mg/kg/8W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in
Biochemical - Enzyme inhibition, induction, or
levels - peptidases
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology.
Information
Directorate, CSIR, Hillside Rd., New Delhi 110
Volume(issue)/page/year: 35,1132,1997
toxic dose
cellular immune response
change in blood or tissue
(Publications &
012, India)
V.1-
1963-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 91250 ug/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 3,402,1955
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 754 mg/kg/52D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 10,459,1981
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
91 mg/kg/26W-I
Kidney, Ureter, Bladder - other changes in urine composition
Endocrine - other changes
Endocrine - changes in adrenal weight
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(1),42,1968
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4300 mg/kg/14W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
28,149,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 462 mg/kg/22W-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Immunological Including Allergic - decrease in cellular immune response
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 39,827,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6510 mg/kg/14D-C
TOXIC EFFECTS :
Behavioral - tremor
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
16,171,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 mg/kg/3D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Liver - other changes
Liver - changes in liver weight
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094)
V.1-
1966-
Volume(issue)/page/year: 34,63,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 504 mg/kg/12W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 37,433,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 53088 ug/kg/24W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 48,535,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 11200 mg/kg/32W-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other hydrolases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
14,626,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 91 mg/kg/26W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,98,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 17500 mg/kg/10W-C
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - other changes
Related to Chronic Data - death
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 141,111,1963
V.4-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 1 gm/kg/14W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
34,47,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 gm/kg/20D-I
TOXIC EFFECTS :
Behavioral - tremor
Liver - hepatitis (hepatocellular necrosis), zonal
Related to Chronic Data - death
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
1,865,1945
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/kg/20D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Liver - changes in liver weight
Endocrine - changes in spleen weight
REFERENCE :
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology.
(Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)1984Volume(issue)/page/year: 9,283,1989
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1867 mg/kg/42D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 7,37,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 1517 mg/kg/42D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - other changes
Endocrine - changes in thyroid weight
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
166,1278,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 12200 mg/kg/61D-C
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - conditioned vitamin deficiency
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 9,179,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 60714 mg/kg/17W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - thyroid weight (goiter)
Endocrine - changes in thyroid weight
REFERENCE :
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St.,
Champaign, IL 61820) V.11921- Volume(issue)/page/year: 53,125,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 12600 mg/kg/18W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - other changes
Endocrine - changes in thyroid weight
REFERENCE :
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St.,
Champaign, IL 61820) V.11921- Volume(issue)/page/year: 53,125,1974
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1225 mg/kg/7W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
Italy) V.11911- Volume(issue)/page/year: 61,113,1975
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
24 mg/kg
multigenerations
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Liver - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
51,983,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 73 mg/kg/26W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 7,215,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 370 mg/kg/80W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1-
1966Volume(issue)/page/year: 19,725,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 21280 mg/kg/38W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - thyroid tumors
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 134,113,1970
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12096 mg/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
Italy) V.11911- Volume(issue)/page/year: 68,11,1982
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7560 mg/kg/90W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,433,1973
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5600 mg/kg/80W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 19,725,1977
TYPE OF TEST
ROUTE OF EXPOSURE
: TD - Toxic dose (other than lowest)
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8100 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
11,88,1967
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3150 mg/kg/15W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see
JCROD7.
Volume(issue)/page/year: 82,25,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TD - Toxic dose (other than lowest)
Oral
Rodent - mouse
3408 mg/kg
multigenerations
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Lungs, Thorax, or Respiration - tumors
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 11,688,1973
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 19 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 19,179,1977
TYPE OF TEST
ROUTE OF EXPOSURE
: TD - Toxic dose (other than lowest)
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 438 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
REONBL Revista Espanola de Oncologia. (Instituto Nacional de Oncologia,
Ciudad Universitaria, Madrid 3, Spain) V.11952Volume(issue)/page/year: 26,177,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 17976 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
Italy) V.11911- Volume(issue)/page/year: 68,11,1982
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 24192 mg/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
Italy) V.11911- Volume(issue)/page/year: 68,11,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 112 mg/kg
SEX/DURATION
: male 56 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 16,1002,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
100 mg/kg
male 1 day(s) pre-mating
1963-
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,53,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
430 mg/kg
female 1-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 12,373,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1890 mg/kg
SEX/DURATION
: female 36 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 3,479,1975/1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 250 mg/kg
SEX/DURATION
: female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New
York, NY 10003) V.151970- Volume(issue)/page/year: 26,283,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,53,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 60 mg/kg
SEX/DURATION
: female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,348,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 21 mg/kg
SEX/DURATION
: lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 228,1222,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 504 mg/kg
SEX/DURATION
: lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
ENPBBC Environmental Physiology and Biochemistry. (Copenhagen, Denmark)
V.2-5, 1972-75. Discontinued. Volume(issue)/page/year: 4,189,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
81 mg/kg
male 4 week(s) pre-mating
female 4 week(s) pre-mating - 2 week(s)
post-birth
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,54,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 124 mg/kg
SEX/DURATION
: female 62 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
ENPBBC Environmental Physiology and Biochemistry. (Copenhagen, Denmark)
V.2-5, 1972-75. Discontinued. Volume(issue)/page/year: 3,127,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
148 mg/kg
female 66 day(s) pre-mating
female 1-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
ENPBBC Environmental Physiology and Biochemistry. (Copenhagen, Denmark)
V.2-5, 1972-75. Discontinued. Volume(issue)/page/year: 3,127,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 40 mg/kg
SEX/DURATION
: female 1-3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 9,267,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 40 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
AMBOCX Ambio. A Journal of the Human Environment. (Pergamon Press Inc.,
Maxwell House, Fairview Park, Elmsford, NY 10523) V.11972Volume(issue)/page/year: 1,148,1972
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
418 mg/kg
SEX/DURATION
: female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-160
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 143 mg/kg
SEX/DURATION
: lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
ENPBBC Environmental Physiology and Biochemistry. (Copenhagen, Denmark)
V.2-5, 1972-75. Discontinued. Volume(issue)/page/year: 5,54,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 40 mg/kg
SEX/DURATION
: female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.11913Volume(issue)/page/year: 65,576,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3 mg/kg
SEX/DURATION
: female 10-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,327,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 17500 ug/kg
SEX/DURATION
: female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76.
For
publisher information, see PSCHDL.
Volume(issue)/page/year: 12,424,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE
: 3540 mg/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 6,83,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 150 mg/kg
SEX/DURATION
: female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.41898- Volume(issue)/page/year: 192,286,1971
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 15 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 50 ppm/24H
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 19,568,1981
1963-
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 50 ppm/24H
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)
Volume(issue)/page/year: 19,568,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
V.1-
1963-
: DNA inhibition
: Insect - Drosophila melanogaster Cells - not
otherwise specified
: 250 ppb
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 41,745,1985
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 ug
REFERENCE :
AJBSAM Australian Journal of Biological Sciences. (Commonwealth
Scientific
and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic.
3002, Australia) V.61953- Volume(issue)/page/year: 27,427,1974
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 ug
REFERENCE :
AJBSAM Australian Journal of Biological Sciences. (Commonwealth
Scientific
and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic.
3002, Australia) V.61953- Volume(issue)/page/year: 27,427,1974
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 ug
REFERENCE :
AJBSAM Australian Journal of Biological Sciences. (Commonwealth
Scientific
and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic.
3002, Australia) V.61953- Volume(issue)/page/year: 27,427,1974
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Mutation test systems - not otherwise specified
: Bird - quail Embryo
: 5 gm/L
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Mutation test systems - not otherwise specified
: Bird - chicken Embryo
: 5 gm/L
TYPE OF TEST
: Cytogenetic analysis
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 30,920,1974
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 30,920,1974
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Bird - quail Embryo
: 5 gm/L
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Cytogenetic analysis
: Bird - chicken Embryo
: 5 gm/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 30,920,1974
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 30,920,1974
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - not otherwise specified
DOSE/DURATION
: 200 ppm
REFERENCE :
ETEAAT Entomologia Experimentalis et Applicata. (Kluwer Academic Pub.
Group, Distribution Centre, POB 322, 3300 AH Dordrecht, Netherlands)
V.11958- Volume(issue)/page/year: 12,221,1969
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 500 mg/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
45,101,1980
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 100 mg/kg
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 17(3),32,1973
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 40 mg/L
REFERENCE :
HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute
of
Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060,
Japan)
No.11951- Volume(issue)/page/year: 29,33,1979
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 200 ug/L/72H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
40,131,1976
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 4620 mg/kg/77D (Continuous)
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 11,1413,1990
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 pmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1547,1984
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 50 umol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 8,1433,1987
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 100 mg/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
45,101,1980
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
REFERENCE :
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York
Ave.,
New York, NY 10003) V.121962- Volume(issue)/page/year: 47,78a,1970
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 10 ug/L
REFERENCE :
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed.,
New
York, Plenum Pub. Corp., 1976 Volume(issue)/page/year: -,555,1976
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Dominant lethal test
: Oral
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,53,1973
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1 gm/kg/2D (Intermittent)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 14,171,1975
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 42600 nmol/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
54,981,1975
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 15 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 gm/kg
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.11949Volume(issue)/page/year: 51,605,1981
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Cytogenetic analysis
Intraperitoneal
Rodent - mouse
50 ppm
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.11959- Volume(issue)/page/year: 16,491,1974
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Unreported
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington
Hill
Hall, Oxford OX3 0BW, UK) V.41979- Volume(issue)/page/year:
6,147,1979
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
REFERENCE :
AJBSAM Australian Journal of Biological Sciences. (Commonwealth
Scientific
and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic.
3002, Australia) V.61953- Volume(issue)/page/year: 27,427,1974
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington
Hill
Hall, Oxford OX3 0BW, UK) V.41979- Volume(issue)/page/year:
6,147,1979
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Unreported
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg/10W (Intermittent)
REFERENCE :
PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington
Hill
Hall, Oxford OX3 0BW, UK) V.41979- Volume(issue)/page/year:
6,147,1979
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Mammal - species unspecified Fibroblast
DOSE/DURATION
: 50 mg/L
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 15,581,1986
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 1 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 5,83,1974
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,179,1991
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 5,83,1974
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,179,1991
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,179,1991
TOXICOLOGY REVIEW
JSIRAC Journal of Scientific and Industrial Research. (Pub. &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110012, India) V.1-4,
1942-45;
V.221963- Volume(issue)/page/year: 34,462,1975
TOXICOLOGY REVIEW
AABIAV Annals of Applied Biology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.11914Volume(issue)/page/year: 35,505,1948
TOXICOLOGY REVIEW
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
29,1,1972
TOXICOLOGY REVIEW
ADCSAJ Advances in Chemistry Series. (American Chemical Soc.,
Distribution
Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037)
1950- Volume(issue)/page/year: 1,160,1950
No.1-
TOXICOLOGY REVIEW
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 7,243,1974
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
48,141,1973
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
V.1-
1962-
Volume(issue)/page/year:
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
59,119,1975
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
ADCSAJ Advances in Chemistry Series. (American Chemical Soc.,
Distribution
Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037)
1950- Volume(issue)/page/year: 1,160,1950
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
No.1-
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
61,37,1975
TOXICOLOGY REVIEW
NOALA4 Nova Acta Leopoldina.
V.1-
1962-
Volume(issue)/page/year:
(Johann Ambrosius Barth Verlag, Postfach
109,
Leipzig DDR-7010, Ger. Dem. Rep.)
Volume(issue)/page/year:
41,271,1975
V.1-
1932-
TOXICOLOGY REVIEW
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga,
113095
Moscow, USSR) No.11957- Volume(issue)/page/year: (8),90,1973
TOXICOLOGY REVIEW
CNDQA8 Cahiers de Nutrition et de Dietetique.
(Editions Meteore, 42, rue
du
Louvre, 75001 Paris, France)
10(3),43,1975
V.1-
1966-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
ECMAAI Economie et Medecine Animales. (Paris, France)
Discontinued. Volume(issue)/page/year: 14,141,1973
V.1-17, 1960-76.
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
56,107,1975
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
AJDDAL American Journal of Digestive Diseases. (New York, NY) V.5-22,
1938-55; New series: V.1-23, 1956-78. For publisher information, see
DDSCDJ. Volume(issue)/page/year: 20,331,1953
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1-
1946-
Volume(issue)/page/year: 38,409,1965
TOXICOLOGY REVIEW
ETOXAC Essays in Toxicology. (Academic Press, Inc., 1 E. First St.,
Duluth,
MN 55802) V.11969- Volume(issue)/page/year: 7,1,1976
TOXICOLOGY REVIEW
IRGGAJ Internationales Archiv fuer Gewerbepathologie und Gewerbehygiene.
(Heidelberg, Fed. Rep. Ger.) V.19-25, 1962-69. For publisher
information,
see IAEHDW. Volume(issue)/page/year: 24,193,1968
TOXICOLOGY REVIEW
BISNAS BioScience. (American Institute of Biological Sciences, 1401
Wilson
Blvd., Arlington, VA 22209) V.141964- Volume(issue)/page/year:
20,958,1970
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971
Volume(issue)/page/year:
5,250,1970
TOXICOLOGY REVIEW
PHTHDT Pharmacology and Therapeutics.
(Pergamon Press Ltd., Headington
Hill
Hall, Oxford OX3 0BW, UK)
7,513,1979
V.4-
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology.
publisher
1979-
Volume(issue)/page/year:
(New York, NY)
V.1-18, 1968-81.
For
information, see JTCTDW.
Volume(issue)/page/year: 13,231,1978
TOXICOLOGY REVIEW
EESADV Ecotoxicology and Environmental Safety.
(Academic Press, Inc., 1
E.
First St., Duluth, MN 55802)
1,89,1977
V.1-
1977-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
EESADV Ecotoxicology and Environmental Safety.
(Academic Press, Inc., 1
E.
First St., Duluth, MN 55802)
1,503,1978
V.1-
1977-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(9),66,1977
(V/O
TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 24,129,1983
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB82-922903
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine.
(New York Academy
of
Medicine, 2 E. 103rd St., New York, NY 10029)
Volume(issue)/page/year: 54,413,1978
Ser 2: V.1-
1925-
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA (1 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,67,1971
OSHA PEL (Gen Indu):8H TWA 1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
Volume(issue)/page/year:
OSHA PEL (Shipyard):8H TWA 1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 1 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 1 mg/m3, Skin, JAN1999
OEL-AUSTRALIA:TWA 1 mg/m3 JAN 1993
OEL-AUSTRIA:TWA 1 mg/m3;Skin JAN 1993
OEL-DENMARK: TWA 1 mg/m3, JAN1999
OEL-BELGIUM:TWA 1 mg/m3 JAN 1993
OEL-FINLAND:TWA 1 mg/m3;STEL 3 mg/m3;Skin JAN 1993
OEL-GERMANY:TWA 1 mg/m3;Skin JAN 1993
OEL-HUNGARY:STEL 0.1 mg/m3;Skin;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 0.1 mg/m3, STEL 0.8 mg/m3, JAN1999
OEL-INDIA:TWA 1 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 1 mg/m3;Skin JAN 1993
OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 1 mg/m3;Skin JAN 1993
OEL-THAILAND:TWA 1 mg/m3 JAN 1993
OEL-TURKEY:TWA 1 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg/m3;STEL 3 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DDT-air:10H CA TWA 0.5 mg/m3 (0.1 mg/m3 LOQ)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 73750
No. of Facilities: 160 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 160 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/182171/AS
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; In vitro
cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-partial sex chrom.
loss
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; Sperm
morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom.
loss
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction;
Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; E coli
polA
without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-131,1978
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
DDT (ORTHO,PARA'-)
RTECS NUMBER
CHEMICAL NAME
: KH7910000
: Ethane,
2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1,1-trichloro
CAS REGISTRY NUMBER
: 789-02-6
BEILSTEIN REFERENCE NO. : 1984770
REFERENCE
: 4-05-00-01885 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 20
MOLECULAR FORMULA
: C14-H9-Cl5
MOLECULAR WEIGHT
: 354.48
WISWESSER LINE NOTATION : GXGGYR BG&R DG
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 2,2-Bis(o,p-chlorophenyl)-1,1,1-trichloroethane
* o,p'-DDT
* 2,4'-DDT
* 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,18,1953
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Behavioral - tremor
:
:
:
:
LDLo - Lowest published lethal dose
Oral
Rodent - mouse
1 gm/kg
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 88,400,1946
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1577 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 11,359,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1600 mg/kg/32D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in adrenal weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
27,1,1974
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
2150 mg/kg
female 1-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 12,373,1974
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 250 mg/kg
SEX/DURATION
: female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New
York, NY 10003) V.151970- Volume(issue)/page/year: 26,283,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,348,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 67500 ug/kg
SEX/DURATION
: female 27 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.
Preston
St., Baltimore, MD 21203) V.11917- Volume(issue)/page/year:
91,1095,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 15 mg/kg
SEX/DURATION
: female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
173,642,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 10 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.118,348,1971
1959-
Volume(issue)/page/year:
** MUTATION DATA **
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10 mg/kg
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 16,493,1985
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 10 ug/L
REFERENCE :
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed.,
New
York, Plenum Pub. Corp., 1976 Volume(issue)/page/year: -,555,1976
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,179,1991
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,179,1991
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 53,179,1991
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
48,141,1973
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
V.1-
1962-
Volume(issue)/page/year:
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
59,119,1975
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
NOALA4 Nova Acta Leopoldina.
(Johann Ambrosius Barth Verlag, Postfach
109,
Leipzig DDR-7010, Ger. Dem. Rep.)
Volume(issue)/page/year:
41,271,1975
V.1-
1932-
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-nonhuman
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DEAE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
KK5075000
Ethanol, 2-(diethylamino)100-37-8
199907
48
C6-H15-N-O
117.22
Q2N2&2
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* DEAE
* Diaethylaminoaethanol
* beta-Diethylaminoethanol
* N-Diethylaminoethanol
* 2-(Diethylamino)ethanol
* 2-N-Diethylaminoethanol
* 2-Diethylaminoethanol
* beta-Diethylaminoethyl alcohol
* Diethylethanolamine
* N,N-Diethylethanolamine
* N,N-Diethyl-N-(beta-hydroxyethyl)amine
* 2-Hydroxytriethylamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg
REACTION SEVERITY
: Severe
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 200 ppm
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,216,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4500 mg/m3/4H
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Sense Organs and Special Senses (Eye) - conjunctive irritation
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 14(11),52,1970
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - rat
DOSE/DURATION
: 1220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
12,486,1968
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5000 mg/m3
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Sense Organs and Special Senses (Eye) - conjunctive irritation
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 14(11),52,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 192 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 94,249,1948
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 650 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 9,31,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 188 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951-
Volume(issue)/page/year: 9,31,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 416 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 9,31,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1260 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,269,1944
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,216,1969
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/6H/5D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
26,479,1965
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 ppm/6H/26W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
26,479,1965
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 76 ppm/6H/14W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 18,418,1992
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 301 ppm/6H/2W-I
TOXIC EFFECTS :
Behavioral - fluid intake
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 18,418,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 21559 mg/kg/1Y-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - ataxia
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0530455-1
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Mammal - dog
DOSE/DURATION
: 4875 mg/kg/39D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - chronic pulmonary edema
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536945
*** REVIEWS ***
ACGIH TLV-TWA 9.6 mg/m3 (2 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 10 ppm (50 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,85,1971
OSHA PEL (Gen Indu):8H TWA 10 ppm (50 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 10 ppm (50 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 10 ppm (50 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 10 ppm (50 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Skin JAN 1993
OEL-AUSTRIA: MAK 10 ppm (50 mg/m3), Skin, JAN1999
OEL-AUSTRIA:TWA 10 ppm (50 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 10 ppm (48 mg/m3);Skin JAN 1993
OEL-DENMARK: TWA 10 ppm (50 mg/m3), Skin, JAN1999
OEL-FINLAND:STEL 10 ppm (50 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 10 ppm (50 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 10 ppm (50 mg/m3);Skin JAN 1993
OEL-POLAND: TWA 50 mg/m3, JAN1999
OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 2-DIETHYLAMINOETHANOL-air:10H TWA 10 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24930
No. of Facilities: 7801 (estimated)
No. of Industries: 71
No. of Occupations: 39
No. of Employees: 23770 (estimated)
NOES - National Occupational
NOES Hazard Code - 24930
No. of Facilities: 11825
No. of Industries: 115
No. of Occupations: 68
No. of Employees: 106878
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
20564 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007
DECABORANE
RTECS NUMBER
: HD1400000
CHEMICAL NAME
: Decaborane(14)
CAS REGISTRY NUMBER
: 17702-41-9
OTHER CAS REGISTRY NOS. : 1304-02-5
LAST UPDATED
: 199907
DATA ITEMS CITED
: 32
MOLECULAR FORMULA
: B10-H14
MOLECULAR WEIGHT
: 122.24
WISWESSER LINE NOTATION :
H2 B10-H12
SYNONYMS/TRADE NAMES :
* Boron hydride (B10H14)
* Decaborane
* Decaborane
* nido-Decaborane(14)
* Tetradecahydrodecaborane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MLSR** U.S. Army, Chemical Corps Medical Laboratories Special Reports.
(Army
Chemical Center, MD) Volume(issue)/page/year: #8,1951
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 46 ppm/4H
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
17,362,1958
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rat
740 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,132,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,335,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 41 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,132,1955
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD224-006
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 33 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,132,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 71 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
11,132,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,335,1953
*** REVIEWS ***
ACGIH TLV-STEL 0.75 mg/m3 (0.15 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.25 mg/m3 (0.05 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 ppm (0.3 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,68,1971
OSHA PEL (Gen Indu):8H TWA 0.05 ppm (0.3 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.05 ppm (0.3 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.05 ppm (0.3 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.05 ppm (0.3 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 005 ppm (0.3 mg/m3);STEL 0.15 ppm;Skin JAN 1993
OEL-AUSTRIA: MAK 0.05 ppm (0.3 mg/m3), Skin, JAN1999
OEL-AUSTRIA:TWA 0.05 ppm (0.3 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 0.05 ppm (0.25 mg/m3);STEL 0.15 ppm;Skin JAN 1993
OEL-DENMARK: TWA 0.05 ppm (0.3 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 0.05 ppm (0.25 mg/m3);STEL 0.15 ppm;Skin JAN 1993
OEL-GERMANY:TWA 0.05 ppm (0.3 mg/m3);Skin JAN 1993
OEL-HUNGARY:TWA 0.3 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.05 ppm (0.3 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 ppm (0.3 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 0.05 ppm (0.25 mg/m3);STEL 0.1 ppm;Skin JAN 1993
OEL-TURKEY:TWA 0.05 ppm (0.3 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DECABORANE-air:10H TWA 0.05 ppm (Sk);STEL 0.15 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DECAHYDRONAPHTHALENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
QJ3150000
Naphthalene, decahydro91-17-8
0878165
3-05-00-00245 (Beilstein Handbook Reference)
199907
23
C10-H18
138.28
L66TJ
Tumorigen
Human
SYNONYMS/TRADE NAMES :
* Bicyclo(4.4.O)decane
* Decalin
* De-kalin
* Dekalina
* Naphthalane
* Naphthane
* Perhydronaphthalene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 100 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago,
National
Assoc. of Mutual Casualty Companies, 1961 Volume(issue)/page/year:
2,40,1961
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
4170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 710 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,215,1992
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 993 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A062-138
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5900 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 319 ppm/8H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A086-341
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg/5D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
25,345,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6 gm/kg/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
25,345,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 ppm/24H/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,785,1985
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 125 ppm/22H/31D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
25,53,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 ppm/24H/90D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Liver - other changes
Endocrine - evidence of thyroid hyperfunction
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,785,1985
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 ppm/24H/90D-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Endocrine - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,785,1985
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 ppm/24H/90D-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,785,1985
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3;Skin JAN 1993
OEL-RUSSIA:STEL 100 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 100 mg/m3, MAC(STEL) 300 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84339
No. of Facilities: 46 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 934 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84339
No. of Facilities: 81 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 249 (estimated)
No. of Female Employees: 74 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8815;8EHQ-0892-8816
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; on test (two year studies), May 1999
DECANE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
HD6550000
Decane
124-18-5
1696981
4-01-00-00464 (Beilstein Handbook Reference)
199712
9
C10-H22
142.32
10H
Tumorigen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 72300 mg/m3/2H
TOXIC EFFECTS :
Behavioral - antipsychotic
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 26(8),53,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 912 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
37,56,1975
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
9,70,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1315
No. of Facilities: 666 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 716 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1315
No. of Facilities: 80 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 1667 (estimated)
No. of Female Employees: 43 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
DECANOL (1-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
HE4375000
Decyl alcohol
112-30-1
1735221
4-01-00-01815 (Beilstein Handbook Reference)
199803
23
C10-H22-O
158.32
Q10
Agricultural Chemical
Tumorigen
Reproductive Effector
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* Agent 504
* Alcohol C-10
* Antak
* C 10 alcohol
* Capric alcohol
* Caprinic alcohol
* Decanol
* n-Decanol
* 1-Decanol
* n-Decyl alcohol
* Dytol S-91
* Epal 10
* Lorol 22
* Nonylcarbinol
* Primary decyl alcohol
* Royaltac
* Royaltac-85
* Royaltac M-2
* Sipol L10
* T 148
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 75 mg/3D (Intermittent)
REACTION SEVERITY
: Severe
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"
Drill,
V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2600 mg/kg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
34,493,1973
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,202,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 83 mg
REACTION SEVERITY
: Severe
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
34,493,1973
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,202,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4720 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
34,493,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4631,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C267,1991
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,42,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,4631,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7.
Volume(issue)/page/year: 11,95,1973
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 3 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(5),61,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/m3/2H/30D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB234-882
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 gm/kg/25W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
9,70,1966
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 35295 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O
Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970Volume(issue)/page/year: 22(1),71,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 35295 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O
Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970Volume(issue)/page/year: 22(1),71,1991
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 10 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83553
No. of Facilities: 219 (estimated)
No. of Industries: 11
No. of Occupations: 26
No. of Employees: 5355 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83553
No. of Facilities: 6909 (estimated)
No. of Industries: 116
No. of Occupations: 84
No. of Employees: 241397 (estimated)
No. of Female Employees: 62584 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9257
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DECYL ALDEHYDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
HD6000000
1-Decanal
112-31-2
1362530
4-01-00-03366 (Beilstein Handbook Reference)
199710
10
C10-H20-O
156.30
VH9
Mutagen
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aldehyde C10
* C-10 aldehyde
* Capraldehyde
* Capric aldehyde
* Caprinaldehyde
* Caprinic aldehyde
* Decaldehyde
* n-Decaldehyde
* Decanal
* n-Decanal
* Decanaldehyde
* Decyl aldehyde
* n-Decyl aldehyde
* 1-Decyl aldehyde
* Decylic aldehyde
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 14372 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
500 mg/24H
Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,1079,1973
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3730 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >41750 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5040 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 mg/disc
REFERENCE :
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical
Association.
(Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54
Asahi-cho,
Abeno-ku, Osaka, 545, Japan) V.241975- Volume(issue)/page/year:
34,267,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5145
No. of Facilities: 3349 (estimated)
No. of Industries: 13
No. of Occupations: 26
No. of Employees: 35717 (estimated)
No. of Female Employees: 16153 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DECYLTRIMETHYLAMMONIUM BROMIDE
RTECS NUMBER
: BP6352000
CHEMICAL NAME
: Ammonium, decyltrimethyl-, bromide
CAS REGISTRY NUMBER
: 2082-84-0
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C13-H30-N.Br
MOLECULAR WEIGHT
: 280.35
WISWESSER LINE NOTATION : 10K1&1&1 &E
SYNONYMS/TRADE NAMES :
* Decyltrimethylammonium bromide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5500 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
47,17,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2800 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
47,17,1980
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEMECLOCYCLINE HYDROCHLORIDE
RTECS NUMBER
: QI7700000
CHEMICAL NAME
: 2-Naphthacenecarboxamide,
7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octah
ydro- 3,6,10,12,12a-pentahydroxy-1,11-dioxo-,
monohydrochloride
CAS REGISTRY NUMBER
: 64-73-3
LAST UPDATED
: 199706
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C21-H21-Cl-N2-O8.Cl-H
MOLECULAR WEIGHT
: 501.35
WISWESSER LINE NOTATION : L E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 MQ
OG
RQ &GH
COMPOUND DESCRIPTOR
: Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* 7-Chloro-6-demethyltetracycline hydrochloride
* Declomycin hydrochloride
* Demeclocycline hydrochloride
* Demethylchlorotetracycline hydrochloride
* Demethylchlortetracycline hydrochloride
* Detravis
* Ledermycin hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 69 mg/kg/4D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - renal function tests depressed
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc.,
Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.11981Volume(issue)/page/year: 5,270,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2372 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,704,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,704,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 275 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AISMAE Archivio Italiano di Scienze Mediche Tropical e di Parassitologia.
Italian Archives of the Science of Tropical Medicine and Parasitology.
(Rome, Italy) V.1-54, 1920-73. Suspended. Volume(issue)/page/year:
43,143,1962
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - woman
DOSE
: 48 ug/kg
SEX/DURATION
: female 28 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034,
Evanston, IL 60204) V.11948- Volume(issue)/page/year: 34,423,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intrauterine
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)
V.11970- Volume(issue)/page/year: 29,553,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4830
No. of Facilities: 33 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 291 (estimated)
No. of Female Employees: 129 (estimated)
DEOXYCHOLIC ACID
RTECS NUMBER
CHEMICAL NAME
: FZ2100000
: 5-beta-Cholan-24-oic acid,
3-alpha,12-alpha-dihydroxyCAS REGISTRY NUMBER
: 83-44-3
BEILSTEIN REFERENCE NO. : 3219882
REFERENCE
: 4-10-00-01608 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 15
MOLECULAR FORMULA
: C24-H40-O4
MOLECULAR WEIGHT
: 392.64
WISWESSER LINE NOTATION : L E5 B666TJ A1 DQ E1 FY1&2VQ OQ
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Cholan-24-oic acid, 3,12-dihydroxy-, (3-alpha,5-beta,12-alpha)* Choleic acid
* Cholerebic
* Cholic acid, deoxy* Cholorebic
* Degalol
* Deoxycholatic acid
* Deoxycholic acid
* 5-beta-Deoxycholic acid
* Desoxycholic acid
* Desoxycholsaeure
* 3,12-Dihydroxycholanic acid
* 3-alpha,12-alpha-Dihydroxycholanic acid
*
*
*
*
*
*
3-alpha,12-alpha-Dihydroxy-5-beta-cholanoic acid
3-alpha,12-alpha-Dihydroxycholansaeure
Droxolan
l7-beta-(1-Methyl-3-carboxypropyl)-etiocholane-3-alpha,12-alpha-diol
Pyrochol
Septochol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association.
(Nara
Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken,
Japan) V.11950- Volume(issue)/page/year: 33,71,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association.
(Nara
Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken,
Japan) V.11950- Volume(issue)/page/year: 33,71,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 20,323,1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin,
Fed.
Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.
Volume(issue)/page/year: 52,779,1926
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2700 mg/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
10,363,1956
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1120 mg/kg/22W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 145,627,1940
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1400 mg/kg/22W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
PRLBA4 Proceedings of the Royal Society of London, Series B: Biological
Sciences. (Royal Soc., 6 Carlton House Terrace, London SW1Y 5AG, UK)
V.761905- Volume(issue)/page/year: 129,439,1940
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 166 mg/kg
SEX/DURATION
: female 12-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003)
Volume(issue)/page/year: 42,215,1990
V.1-
1968-
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
158,45,1985
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 2800 umol/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
60,192,1987
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,447,1984
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 7250 ug/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
9,177,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80398
No. of Facilities: 153 (estimated)
No. of Industries: 2
No. of Occupations: 7
No. of Employees: 3527 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80398
No. of Facilities: 82 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 2416 (estimated)
No. of Female Employees: 1577 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEOXYCHOLIC ACID SODIUM
RTECS NUMBER
CHEMICAL NAME
: FZ2250000
: 5-beta-Cholan-24-oic acid,
3-alpha,12-alpha-dihydroxy-, sodium salt
CAS REGISTRY NUMBER
: 302-95-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 20
MOLECULAR FORMULA
: C24-H39-O4.Na
MOLECULAR WEIGHT
: 414.62
WISWESSER LINE NOTATION : L E5 B666TJ A1 DQ E1 FY1&2VO OQ &-NACOMPOUND DESCRIPTOR
: Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Cholan-24-oic acid, 3,12-dihydroxy-, monosodium salt,
(3-alpha,5-beta,12-alpha)* Deoxycholate sodium
* Deoxycholic acid sodium salt
* Desoxycholate sodium
* Dihydroxy 3-12 cholanate de Na
* 3,12-Dihydroxy-cholan-24-oic acid monosodium salt,
(3-alpha,5-beta,12-alpha)* 3-alpha,12-alpha-Dihydroxy-5-beta-cholan-24-oic acid sodium salt
* Natrium-3-alpha,12-alpha-dihydroxycholanat
* Na-Desoxycholat
* Sodium deoxycholate
* Sodium 7-deoxycholate
* Sodium deoxycholic acid
* Sodium desoxycholate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1370 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 3,45,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - rat
DOSE/DURATION
: 123 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 3,45,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2430 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 3,45,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 20,323,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1050 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(103),29,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 36 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan)
(103),29,1985
V.1-
1886-
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 815 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 3,45,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 107 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 90,18,1952
V.4-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - other changes
REFERENCE :
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin,
Fed.
Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.
Volume(issue)/page/year: 52,779,1926
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 700 mg/kg/28D-C
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - changes in liver weight
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 3,45,1969
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 gm/kg/30D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Related to Chronic Data - death
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
103,29,1985
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1400 mg/kg
SEX/DURATION
: male 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 3,45,1969
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 5 pph/3H
REFERENCE :
CSHSAZ Cold Spring Harbor Symposia on Quantitative Biology. (Cold Spring
Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724) V.11933Volume(issue)/page/year: 12,256,1947
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 960 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
93,101,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 25 mg/L
REFERENCE :
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266,
Phildelphia, PA 19103) V.11978- Volume(issue)/page/year:
16,227,1991
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: DNA inhibition
: Human Lymphocyte
: 100 mg/L
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 28,504,1982
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Rectal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10 umol/kg
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research.
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
75,29,1984
(Tokyo, Japan)
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83389
No. of Facilities: 138 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 361 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83389
No. of Facilities: 673 (estimated)
No. of Industries: 6
No. of Occupations: 9
No. of Employees: 7419 (estimated)
No. of Female Employees: 5995 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEOXYCORTICOSTERONE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Cortexone
:
:
:
:
:
:
:
:
:
HG0350000
11-Deoxycorticosterone
64-85-7
199703
4
C21-H30-O3
330.51
L E5 B666 OV MUTJ A E FV1Q
Mutagen
Reproductive Effector
*
*
*
*
*
*
Desoxycorticosterone
Desoxycortone
21-Hydroxypregn-4-ene-3,20-dione
21-Hydroxyprogesterone
4-Pregnen-21-ol-3,20-dione
Progesterone, 21-hydroxy*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 7,673,1964
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intramuscular
Rodent - rat
14500 ug/kg
female 7 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
41,710,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 8750 ug/kg
SEX/DURATION
: female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11896- Volume(issue)/page/year:
102,347,1955
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1370,49,1996
DEOXYCYTIDINE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
1964-
Volume(issue)/page/year:
HA3800000
Cytidine, 2'-deoxy951-77-9
0087567
4-25-00-03662 (Beilstein Handbook Reference)
199701
5
C9-H13-N3-O4
227.25
T6NVNJ DZ A- ET5OTJ B1Q CQ
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* dCYD
* Cytosine, deoxyribonucleoside
* Cytosine deoxyriboside
* Deoxycytidine
* 2'-Deoxycytidine
* Deoxyribose cytidine
* Desoxycytidin
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 800 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag,
Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.11946Volume(issue)/page/year: 32,861,1977
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mmol/L
REFERENCE :
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France)
1971Volume(issue)/page/year: 64,809,1982
V.53-
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-human lymphocytes;
In
vitro SCE-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEOXYGUANOSINE (2'-)
RTECS NUMBER
: MF8760000
CHEMICAL NAME
: Guanosine, 2'-deoxyCAS REGISTRY NUMBER
: 961-07-9
LAST UPDATED
: 199701
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C10-H13-N5-O4
MOLECULAR WEIGHT
: 267.28
WISWESSER LINE NOTATION : T56 BN DN FMYMVJ GUM D- ET5OTJ B1Q CQ
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Deoxyguanosine
* 2'-Deoxyguanosine
* Guanine deoxyriboside
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 3,181,1968
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mmol/L
REFERENCE :
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France)
1971Volume(issue)/page/year: 64,809,1982
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Cytogenetic analysis
: Rodent - hamster Fibroblast
: 500 umol/L
V.53-
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.11929- Volume(issue)/page/year: 49,667,1984
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 500 umol/L
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.11929- Volume(issue)/page/year: 49,667,1984
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mmol/L
REFERENCE :
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France)
1971Volume(issue)/page/year: 64,809,1982
V.53-
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 50 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 48,686,1962
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1005
No. of Facilities: 35 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 115 (estimated)
No. of Female Employees: 64 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEOXYRIBONUCLEASE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
RF0750000
Nuclease, deoxyribo9003-98-9
199701
7
Mutagen
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Alkaline deoxyribonuclease
Alkaline dnase
Deoxyribonuclease
Deoxyribonuclease A
Deoxyribonuclease I
Deoxyribonuclease (pancreatic)
Deoxyribonucleic phosphatase
Desoxyribonuclease
Dnaase
DNA depolymerase
DNA endonuclease
DNA nuclease
Dnasw
Dnase I
Dornase
Dornava
Dornavac
E.C. 3.1.4.5
Endodeoxyribonuclease I
Escherichia coli endonuclease I
Pancreatic deoxyribonuclease
Pancreatic dornase
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
: Cytogenetic analysis
: Insect - Drosophila melanogaster Cells - not
otherwise specified
: 1 gm/L
DOSE/DURATION
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies
in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,
Calcutta
700 019, India) V.11958- Volume(issue)/page/year: 2,85,1959
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Insect - grasshopper Cells - not otherwise
specified
DOSE/DURATION
: 1 gm/L
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies
in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,
Calcutta
700 019, India) V.11958- Volume(issue)/page/year: 2,85,1959
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 5000 ppm
REFERENCE :
SFCRAO Collection of Papers Presented at the Annual Symposium on
Fundamental
Cancer Research. (Baltimore, MD) V.1-29, 1946-76. For publisher
information, see AFCPDR. Volume(issue)/page/year: 23,346,1970
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2500 units
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
307,315,1994
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81370
No. of Facilities: 181 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 1471 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81370
No. of Facilities: 116 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 8763 (estimated)
No. of Female Employees: 8131 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEOXYRIBONUCLEIC ACID
RTECS NUMBER
: HG1933000
CHEMICAL NAME
: Deoxyribonucleic acid
CAS REGISTRY NUMBER
: 9007-49-2
LAST UPDATED
: 199509
DATA ITEMS CITED
: 5
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Calf thymus DNA
* Desoxyribose nucleic acid
* DNA
* Nucleic acids, deoxyribo
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD - Lethal dose
Intraperitoneal
Rodent - mouse
>1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects
REFERENCE :
ANYAA9 Annals of the New
Sciences, 2 E. 63rd St.,
Volume(issue)/page/year:
not reported other than lethal dose value
York Academy of Sciences.
New York, NY 10021) V.160,251,1954
(New York Academy of
1877-
** MUTATION DATA **
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1000 ppm
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval
Rd.,
London NW1 7DX, UK) V.11955- Volume(issue)/page/year: 20,271,1974
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 30 ng
REFERENCE :
DEBIAO Developmental Biology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11959- Volume(issue)/page/year: 43,189,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83257
No. of Facilities: 74 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 91 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83257
No. of Facilities: 181 (estimated)
No. of Industries: 3
No. of Occupations: 14
No. of Employees: 3694 (estimated)
No. of Female Employees: 2539 (estimated)
DEOXYRIBONUCLEIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
HG1934000
Deoxyribonucleic acid (calf thymus)
91080-16-9
199410
1
Mutagen
* Calf thymus DNA pyrolyzate
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mg/plate
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
2,335,1977
DER 736
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
COMPOUND DESCRIPTOR
: RR0430000
: Oxirane, (chloromethyl)-, polymer with
alpha-hydro-omega-hydroxypoly(oxy(methyl-1,2ethanediyl))
: 9072-62-2
: 199806
: 8
: ((C3-H6-O)n-H2-O.C3-H5-Cl-O)x
: Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* DER 736
* D.E.R. 732 epoxy resin
* D.E.R. 736 epoxy resin
* alpha-Hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl)),
(chloromethyl)oxirane polymer
* Polypropylene glycol, (chloromethyl)oxirane polymer
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 uL/24H
REACTION SEVERITY
: Mild
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0529967
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD - Lethal dose
: Oral
: Rodent - rat
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0529965
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 pph
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,307,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 pph
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,307,1979
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0566
No. of Facilities: 462 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 1014 (estimated)
No. of Female Employees: 427 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DESOXYBENZOIN
RTECS NUMBER
: AM9662500
CHEMICAL NAME
: Acetophenone, 2-phenylCAS REGISTRY NUMBER
: 451-40-1
BEILSTEIN REFERENCE NO. : 1072876
REFERENCE
: 4-07-00-01393 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C14-H12-O
MOLECULAR WEIGHT
: 196.26
WISWESSER LINE NOTATION : RV1R
SYNONYMS/TRADE NAMES :
* Benzyl phenyl ketone
* Deoxybenzoin
* Desoxybenzoin
* 1,2-Diphenylethanone
* Ethanone, 1,2-diphenyl* 2-Phenylacetophenone
* Phenyl benzyl ketone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#03836
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DESYL CHLORIDE
RTECS NUMBER
: AM6825000
CHEMICAL NAME
: Acetophenone, alpha-chloro-alpha-phenylCAS REGISTRY NUMBER
: 447-31-4
BEILSTEIN REFERENCE NO. : 0744474
REFERENCE
: 3-07-00-02106 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C14-H11-Cl-O
MOLECULAR WEIGHT
: 230.70
WISWESSER LINE NOTATION : GYR&VR
SYNONYMS/TRADE NAMES :
* Acetophenone, 2-chloro-2-phenyl* alpha-Chlorobenzyl phenyl ketone
* alpha-Chlorodeoxybenzoin
* 2-Chloro-1,2-diphenylethanone
* 2-Chloro-2-phenylacetophenone
* Desyl chloride
* Ethone, 2-chloro-1,2-diphenyl-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 5,284,1953
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEUTERIUM OXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
ZC0230000
Water, heavy (D2-O)
7789-20-0
199701
6
D2-O
20.02
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Deuterium oxide
* Dideuterium oxide
* Heavy water
* Heavy water-d2
* Water-d2
* Water(sup 2)-H2
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 840 gm/kg
SEX/DURATION
: male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 208,1119,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3360 gm/kg
SEX/DURATION
: female 56 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
127,1445,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2940 gm/kg
SEX/DURATION
: male 49 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 50,306,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1680 gm/kg
SEX/DURATION
: male 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.11877Volume(issue)/page/year: 84,763,1960
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal
translocation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEXAMETHASONE
RTECS NUMBER
CHEMICAL NAME
: TU3980000
: Pregna-1,4-diene-3,20-dione,
9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methylCAS REGISTRY NUMBER
: 50-02-2
LAST UPDATED
: 199812
DATA ITEMS CITED
: 88
MOLECULAR FORMULA
: C22-H29-F-O5
MOLECULAR WEIGHT
: 392.51
WISWESSER LINE NOTATION : L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
COMPOUND DESCRIPTOR
: Drug
Mutagen
Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* Aeroseb-dex
* Aphtasolon
* Azium
* Calonat
* Corsone
* Decaderm
* Decadron
* Decasone
* Decaspray
* Dectancyl
* 1-Dehydro-16-alpha-methyl-9-alpha-fluorohydrocortisone
* Dekacort
* Deltafluorene
* Dergramin
* Deronil
* Desadrene
* Desametasone
* Desamethasone
* Desameton
* Dexa-Cortidelt
* Dexa-Cortisyl
* Dexadeltone
* Dexalona
* Dexameth
* Dexamethasone
* Dexamethasone alcohol
* Dexamethazone
* Dexapolcort
* Dexaprol
* Dexa-Scheroson
* Dexason
* Dexone
* Dextelan
* Dezone
* DXMS
* Fluorocort
* delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
* 9-alpha-Fluoro-16-alpha-methylprednisolone
*
9-alpha-Fluoro-16-alpha-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol
-3,20-dione
*
4-alpha-Fluoro-16-alpha-methyl-11-beta,17,21-trihydroxypregna-1,4-diene3,20-dione
*
9-Fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-d
ione
*
9-alpha-Fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4diene-3,20-dione
* Fortecortin
* Gammacorten
* Hexadecadrol
* Hexadrol
* HL-Dex
* Maxidex
* 16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
* 16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
* 16-alpha-Methyl-9-alpha-fluoroprednisolone
*
16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol
-3,20-dione
*
16-alpha-Methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4diene-3,20-dione
* Mexidex
* Millicorten
* MK 125
* Oradexon
* Prednisolone F
* Prednisolon F
* SK-Dexamethasone
* Superprednol
* Visumetazone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Multiple routes
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 4759 ug/kg/18D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus, NJ 07094) V.31977Volume(issue)/page/year: 21,238,1995
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 28,687,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 54 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 28,687,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
8,250,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry.
(New
York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:
2,281,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 21,2117,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - rabbit
7200 ug/kg
Sense Organs and Special Senses (Eye) - lacrimation
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 28,687,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 70 mg/kg/14D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
Immunological Including Allergic - decrease in cellular immune response
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 98,111,1995
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 26700 ug/m3/30M/21D-I
TOXIC EFFECTS :
Endocrine - other changes
Endocrine - changes in thymus weight
Blood - changes in erythrocyte (RBC) count
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.11975- Volume(issue)/page/year:
2,97,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7500 ug/kg/30D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of
Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.11976- Volume(issue)/page/year: 7(Suppl
1),15,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 mg/kg/14D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Blood - changes in leukocyte (WBC) count
Immunological Including Allergic - hypersensitivity delayed
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 50,266,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 ug/kg/26W-I
TOXIC EFFECTS :
Endocrine - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Related to Chronic Data - changes in testicular weight
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.11975- Volume(issue)/page/year:
2,113,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 280 ug/kg/28D-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
Endocrine - changes in spleen weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 8,2349,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 mg/kg/5D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc.,
Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.11981Volume(issue)/page/year: 31,443,1998
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3821 ug/kg/14D-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
Blood - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A080-636
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6 mg/kg
SEX/DURATION
: female 8-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 32,35A,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel,
A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,85,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 880 ug/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year:
18,1021,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 8800 ug/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year:
18,1021,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7500 ug/kg
SEX/DURATION
: female 15-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 163,1269,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 8800 ug/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - live birth index (measured after
birth)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year:
18,1021,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Administration onto the skin
Rodent - rat
4200 ug/kg
male 9 week(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.11975- Volume(issue)/page/year:
8,75,1982
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1802 ug/kg
SEX/DURATION
: male 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.11975- Volume(issue)/page/year:
8,55,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1500 ug/kg
SEX/DURATION
: female 17-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New
York, NY 10003) V.151970- Volume(issue)/page/year: 68,39,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5 mg/kg
SEX/DURATION
: female 14-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11925Volume(issue)/page/year: 272,L665,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3 mg/kg
SEX/DURATION
: female 14-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 75,125,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
2 mg/kg
female 20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
PEPUES Pediatric Pulmonology. (W.B. Saunders Co., W. Washington Square,
Philadelphia, PA 19105) V.11985- Volume(issue)/page/year: 8,138,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1500 ug/kg
SEX/DURATION
: female 16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
IJVNAP International Journal for Vitamin and Nutrition Research. (Verlag
Hans Huber, Laenggasstr. 76, CH-3000 Bern 9, Switzerland) V.411971Volume(issue)/page/year: 64,93,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3 mg/kg
SEX/DURATION
: male 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 23,961,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 700 ug/kg
SEX/DURATION
: female 12-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica,
Skolegade 12 E, DK-2500 Valby, Denmark) No.11948Volume(issue)/page/year: 173,44,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 900 ug/kg
SEX/DURATION
: female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
71,367,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1100 ug/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 17,310,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3600 ug/kg
SEX/DURATION
: female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
71,367,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 11 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,12A,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1500 ug/kg
SEX/DURATION
: female 16-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
JEZOAO Journal of Experimental Zoology. (Alan R. Liss, Inc., 41 E. 11th
St., New York, NY 10003) V.11904- Volume(issue)/page/year:
279,54,1997
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
Reproductive weight
gain)
Reproductive Reproductive REFERENCE :
JCINAO Journal
York Ave., New
101,2174,1998
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
Reproductive Reproductive weight
gain)
Reproductive REFERENCE :
JEZOAO Journal
St., New York,
272,281,1995
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
800 ug/kg
female 15-22 day(s) after conception
Effects on Newborn - growth statistics (e.g.%, reduced
Effects on Newborn - biochemical and metabolic
Effects on Newborn - other postnatal measures or effects
of Clinical Investigation. (Rockefeller Univ. Press, 1230
York, NY 10021) V.11924- Volume(issue)/page/year:
:
:
:
:
:
TDLo - Lowest published toxic dose
Parenteral
Rodent - rat
1500 ug/kg
female 16 day(s) after conception
Effects on Embryo or Fetus - other effects to embryo
Effects on Newborn - growth statistics (e.g.%, reduced
Effects on Newborn - physical
of Experimental Zoology. (Alan R. Liss, Inc., 41 E. 11th
NY 10003) V.11904- Volume(issue)/page/year:
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel,
A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,85,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 3600 ug/kg
SEX/DURATION
: female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
71,367,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 28800 ug/kg
SEX/DURATION
: female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
71,367,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 24,741,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Subcutaneous
: Rodent - mouse
DOSE
: 400 ug/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 24,741,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 50 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 9,25,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Ocular
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1200 ug/kg
SEX/DURATION
: female 10-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 16,175,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Ocular
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 6 mg/kg
SEX/DURATION
: female 10-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 16,175,1977
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
e.g., stunted fetus)
TDLo - Lowest published toxic dose
Parenteral
Rodent - mouse
6 mg/kg
female 16 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
REFERENCE :
LAINAW Laboratory Investigation.
St., Baltimore, MD 21202) V.136,395,1977
(Williams & Wilkins Co., 428 E. Preston
1952- Volume(issue)/page/year:
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 400 ug/kg
SEX/DURATION
: female 16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21202) V.11952- Volume(issue)/page/year:
36,395,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Mammal - dog
DOSE
: 18 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 17,937,1979
1963-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Primate - monkey
DOSE
: 3700 mg/kg
SEX/DURATION
: female 18-23 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - physical
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 145,920,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 400 ug/kg
SEX/DURATION
: female 13-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel,
A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,85,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2 mg/kg
SEX/DURATION
: female 13-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th
International Committee on Laboratory Animals, Hanover, 1972," Speigel,
A.
ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
Volume(issue)/page/year: -,85,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 130 ug/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 17,327,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 390 ug/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 17,327,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 1600 ug/kg
SEX/DURATION
: female 25-26 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309
W.
Clark St., Champaign, IL 61820)
42,131,1976
V.1-
1942-
Volume(issue)/page/year:
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Ocular
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 554 ug/kg
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
16,773,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 2 mg/kg
SEX/DURATION
: female 25-26 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309
W.
Clark St., Champaign, IL 61820) V.11942- Volume(issue)/page/year:
37,305,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 360 ug/kg
SEX/DURATION
: female 25-27 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309
W.
Clark St., Champaign, IL 61820) V.11942- Volume(issue)/page/year:
36,1170,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - pig
DOSE
: 6667 ug/kg
SEX/DURATION
: female 14 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
9,105,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Mammal - pig
DOSE
: 6670 ug/kg
SEX/DURATION
: female 14 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309
W.
Clark St., Champaign, IL 61820) V.11942- Volume(issue)/page/year:
37,305,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Mammal - pig
DOSE
: 3750 ug/kg
SEX/DURATION
: female 14 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309
W.
Clark St., Champaign, IL 61820) V.11942- Volume(issue)/page/year:
36,1170,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 4 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)
V.1-98, 1953-86. For Publisher information, see DEVPED
Volume(issue)/page/year: 36,101,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Mammal - domestic
560 ug/kg
female 22-23 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
CSCIAE Clinical Science. (Biochemical Society Book Depot, POB 32,
Commerce
Way Colchester, Essex CO2 8HP, UK) V.1-44, 1933-73; V.56- 1979Volume(issue)/page/year: 94,149,1998
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - horse, donkey
DOSE
: 1905 ug/kg
SEX/DURATION
: female 45 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309
W.
Clark St., Champaign, IL 61820) V.11942- Volume(issue)/page/year:
44,1072,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - horse, donkey
DOSE
: 800 ug/kg
SEX/DURATION
: female 45-46 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
JAVMA4 Journal of the American Veterinary Medical Association. (American
Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)
V.481915- Volume(issue)/page/year: 165,721,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - domestic
DOSE
: 120 ug/kg
SEX/DURATION
: female 40 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA
94022)
V.11974- Volume(issue)/page/year: 23,325,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Intramuscular
Mammal - cattle
60 ug/kg
female 39 week(s) after conception
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
REFERENCE :
THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA
94022)
V.11974- Volume(issue)/page/year: 32,501,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Mammal - horse, donkey
DOSE
: 889 ug/kg
SEX/DURATION
: female 45-46 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
JRFSAR Journal of Reproduction and Fertility, Supplement. (Biochemical
Soc.
Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) No.11966- Volume(issue)/page/year: 23,637,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - species unspecified
DOSE
: 877 mg/kg
SEX/DURATION
: male 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York,
NY
10003) V.11945- Volume(issue)/page/year: 89,240,1974
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
370,49,1996
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
308,89,1994
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Sister chromatid exchange
: Human Lymphocyte
: 1 mg/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
308,89,1994
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
51,1078,1991
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 100 nmol/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 161,29,1985
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 14,625,1978
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
308,89,1994
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - mouse Bone marrow
DOSE/DURATION
: 1 mmol/L
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A080-636
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 3 mg/kg
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
54,931,1975
TYPE OF TEST
ROUTE OF EXPOSURE
: Mutation test systems - not otherwise specified
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 3 mg/kg
REFERENCE :
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
54,931,1975
(Washington, DC)
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,3849,1979
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 10 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,2536,1983
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
308,89,1994
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Bird - chicken Embryo
DOSE/DURATION
: 150 pmol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 257,804,1975
*** REVIEWS ***
TOXICOLOGY REVIEW
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.11920Volume(issue)/page/year: 96,985,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81600
No. of Facilities: 862 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 1035 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1854
No. of Facilities: 403 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 4029 (estimated)
No. of Female Employees: 2015 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81600
No. of Facilities: 728 (estimated)
No. of Industries: 4
No. of Occupations: 20
No. of Employees: 30657 (estimated)
No. of Female Employees: 17738 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DEXTRAN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
:
:
:
:
:
:
TQ8100000
Polyglusol
9004-54-0
199701
4
Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 13500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle contraction or spasticity
REFERENCE :
GETRE8 Gematologiya i Transfuziologiya. Hematology and Transfusion
Science.
(V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.281983Volume(issue)/page/year: 31(10),38,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83342
No. of Facilities: 86 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 369 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83342
No. of Facilities: 432 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 7612 (estimated)
No. of Female Employees: 4671 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEXTRAN SULFATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
:
:
:
:
:
:
HH9290000
Dextran sulfate sodium
9011-18-1
199810
13
Tumorigen
Drug
SYNONYMS/TRADE NAMES :
* Asuro
* Dexnon
* Dextran, hydrogen sulfate, sodium salt
* Dextran sodium sulfate
* Dextran sulfate sodium salt
* Dextrarine
* Dexulate
* DS-M-1
* MDS
* MDS (polysaccharide)
* Sodium dextran sulfate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 13,1318,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 473 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 13,1318,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 13,1318,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 13,1318,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 19 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,481,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 gm/kg/30D-C
TOXIC EFFECTS :
Endocrine - other changes
Blood - changes in spleen
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 13,1318,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 268800 mg/kg/24W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Blood - normocytic anemia
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,573,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 89600 mg/kg/4W-C
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes
Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 6,573,1972
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 330 gm/kg/94W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Gastrointestinal - colon tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,353,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TD - Toxic dose (other than lowest)
Oral
Rodent - rat
335 gm/kg/19W-C
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Gastrointestinal - colon tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 66,579,1981
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 600 gm/kg/69W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - colon tumors
Endocrine - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
18,29,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 645 gm/kg/31W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - colon tumors
REFERENCE :
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
17,215,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DEXTRIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
:
:
:
:
:
:
HH9450000
Dextrins
9004-53-9
199710
7
(C6-H10-O5)n.xH2-O
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 350 mg(Fe)/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,537,1972
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83807
No. of Facilities: 19004 (estimated)
No. of Industries: 157
No. of Occupations: 100
No. of Employees: 140039 (estimated)
NOES - National Occupational
NOES Hazard Code - X9692
No. of Facilities: 16493
No. of Industries: 173
No. of Occupations: 115
No. of Employees: 325878
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
101216 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIACETONE GLUCOSE
RTECS NUMBER
CHEMICAL NAME
alpha-DCAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
: LZ4958000
: Glucofuranose, 1:2,5:6-di-O-isopropylidene-,
:
:
:
:
:
582-52-5
199709
2
C12-H20-O6
260.32
WISWESSER LINE NOTATION : T55 BO DO FOTJ C1 C1 HQ G- DT5O COTJ B1 B1
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Diacetone glucose
* Diacetone-D-glucose
* 1:2,5:6-Di-O-isopropylidene-alpha-D-glucofuranose
* 1:2,5:6-Di-O-isopropyliden-alpha-D-glucofuranose
* alpha-D-Glucofuranose, 1,2:5,6-bis-O-(1-methylethylidene)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Behavioral - analgesia
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 29,986,1979
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIACETOXYIODO BENZENE
RTECS NUMBER
: DA3525000
CHEMICAL NAME
: Benzene, iodoso-, diacetate
CAS REGISTRY NUMBER
: 3240-34-4
LAST UPDATED
: 199712
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C10-H11-I-O4
MOLECULAR WEIGHT
: 322.11
WISWESSER LINE NOTATION : 1VO-I-R &OV1 &5/10
SYNONYMS/TRADE NAMES :
* Benzene, (diacetoxyiodo)* Benzene, (dihydroxyiodo)-, diacetate
* Bis(acetato)phenyliodine
* (Diacetoxyiodo)benzene
* Iodine, bis(acetato-O)phenyl* Iodobenzene diacetate
* Iodosobenzene diacetate
* Phenyliodine diacetate
* Phenyliodine(III) diacetate
* Phenyliodo diacetate
* Phenyliodoso diacetate
* Phenyliodosyl diacetate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02976
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIALLYLAMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
UC6650000
2-Propen-1-amine, N-2-propenyl124-02-7
0773718
4-04-00-01060 (Beilstein Handbook Reference)
199710
16
C6-H11-N
97.18
1U2M2U1
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Di-2-propenylamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 ug/24H
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Rinsed with water
: Administration into the eye
: Rodent - rabbit
DOSE/DURATION
: 50 mg/20S
REACTION SEVERITY
: Severe
REFERENCE :
AEHLAU Archives of Environmental Health.
St.,
NW, Washington, DC 20016) V.119601,343,1960
(Heldref Pub., 4000 Albemarle
Volume(issue)/page/year:
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 5 ppm/5M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
1,343,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 578 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - other changes
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
1,343,1960
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 795 ppm/8H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - lacrimation
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
1,343,1960
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - mouse
DOSE/DURATION
: 355 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,43,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 187 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - other changes
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
1,343,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 280 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 2100 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 14,80,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR)
Volume(issue)/page/year: 14,80,1975
No.1-
1961-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 ppm/7H/50D-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
1,343,1960
*** REVIEWS ***
TOXICOLOGY REVIEW
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 44,129,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINE GREEN B
RTECS NUMBER
CHEMICAL NAME
: QJ6194500
: 2,7-Naphthalenedisulfonic acid,
4-amino-5-hydroxy-6-((4'-((4-hydroxyphenyl)azo)
(1,1'-biphenyl)-4-yl)azo)-3-((4-nitrophenyl)azo)-,
disodium salt
: 4335-09-5
: 199710
: 6
: C34-H24-N8-O10-S2.2Na
: 814.76
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* Airedale Green BD
* Aizen Direct Green BH
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Amanil Green B
Apomine Green B
Atlantic Green 2B
Atul Direct Green B
Azine Green BX
Azocard Green B
Azomine Green B
Belamine Green BX
Bencidal Green B
Benzanil Green B
Benzanil Green BN
Benzo Green B
Benzo Green BG-CF
Benzo Green CA-CF
Benzo Green GA-CF
Brasilamina Green G
Calcomine Green BY
Chloramine Green B
Chloramine Green 2B
Chloramine Green BC
Chloramine Green 3G
Chlorazol Green BN
Chlorazol Green BNP
Chlorazol Paper Green BN
C.I. 30295
C.I. Direct Green 6
C.I. Direct Green 6, disodium salt
Cotton Green B
Cresotine Green B
Diacotton Green B
Diamine Green B
Diaphtamine Green B
Diazine Green B
Diazine Green DB
Diazol Green B
Diazol Green BJ
Diphenyl Green BB
Diphenyl Green BY
Diphenyl Green C
Diphenyl Green GPD
Diphenyl Green KG
Diphenyl Green MB
Direct Brilliant Green BB
Direct Brilliant Green C
Direct Brilliant Green CBM
Direct Green
Direct Green 6
Direct Green A
Direct Green 2B
Direct Green BN
Direct Green BP
Direct Green BX
Direct Green MB
Enianil Green B
Enianil Green BBN
Erie Green GPD
Erie Green MT
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Erie Green TCM
Fenamin Green A
Fenamin Green B
Fenamin Green G
Fixanol Green BN
Hispamin Green B
Kayaku Direct Green B
Mitsui Direct Green BC
Naphtamine Green B
Naphthalene Leather Green BL
Nippon Green B
Orbamin Green B
Paramine Green B
Paramine Green BN
Phenamine Green BG
Phenamine Green C
Phenamine Green G
Pheno Bright Green
Pontamine Green BXN
Pontamine Green GXN
Tertrodirect Green B
Vondacel Green B
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14730 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 215154
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3990 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 215154
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1414
No. of Facilities: 84 (estimated)
No. of Industries: 2
No. of Occupations: 8
No. of Employees: 1095 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINO TOULENE (2,3-)
RTECS NUMBER
: XS9550000
CHEMICAL NAME
: Toluene-2,3-diamine
CAS REGISTRY NUMBER
: 2687-25-4
BEILSTEIN REFERENCE NO. : 0907184
REFERENCE
: 3-13-00-00277 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C7-H10-N2
MOLECULAR WEIGHT
: 122.19
SYNONYMS/TRADE NAMES :
* 1,2-Benzenediamine, 3-methyl* 2,3-Diaminotoluene
* 3-Methyl-1,2-benzenediamine
* 2,3-Toluylenediamine
* 2,3-Tolylenediamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 286 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GPOLA4 Genetica Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1,
Poland)
V.11960- Volume(issue)/page/year: 26,109,1985
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINOACRIDINE HYDROCHLORIDE (3,6-)
RTECS NUMBER
: AR9064000
CHEMICAL NAME
: Acridine, 3,6-diamino-, monohydrochloride
CAS REGISTRY NUMBER
: 952-23-8
LAST UPDATED
: 199904
DATA ITEMS CITED
: 14
MOLECULAR FORMULA
: C13-H11-N3.Cl-H
MOLECULAR WEIGHT
: 245.73
WISWESSER LINE NOTATION : T C666 BNJ EZ MZ &GH
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 3,6-Diaminoacridine hydrochloride hemihydrate
* 3,6-Diaminoacridine monohydrochloride
* 2,8-Diaminoacridinium chloride monohydrochloride
* NCI-C04137
* Proflavine hydrochloride
* Proflavine monohydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 190 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
10,649,1937
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5040 mg/kg/6W-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-5,1977
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27 gm/kg/109W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-5,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 35 gm/kg/104W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-5,1977
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 300 ng/plate
REFERENCE :
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan
Ave.,
Albany, NY 12210) No.271979- Volume(issue)/page/year: 27,283,1980
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 300 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
222,191,1989
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
204,323,1988
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1204,323,1988
1964-
Volume(issue)/page/year:
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,195,1980
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,195,1980
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** STATUS IN U.S. ***
NCI Carcinogenesis Bioassay (feed);clear evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-5,1977
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-5,1977
DIAMINOBENZIDINE (3,3'-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
DV8750000
3,3'4,4'-Biphenyltetramine
91-95-2
1212988
4-13-00-00530 (Beilstein Handbook Reference)
199812
13
C12-H14-N4
214.30
ZR BZ DR CZ DZ
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* (1,1'-Biphenyl)-3,3',4,4'-tetramine
*
*
*
*
3,3'-Diaminobenzidene
3,3',4,4'-Diphenyltetramine
3,3',4,4'-Tetraaminobiphenyl
3,3',4,4'-Tetraaminodiphenyl
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
26,619,1966
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 260 mg/m3/4H
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cyanosis
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537196
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1834 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(1),94,1981
(V/O
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9000 mg/kg/27D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
28,924,1968
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 25 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
158,19,1985
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 140 umol/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 174,39,1979
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 500 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
319,19,1993
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
319,19,1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5448
No. of Facilities: 38 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 135 (estimated)
No. of Female Employees: 95 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINOBENZIDINE TETRAHYDROCHLORIDE (3,3-)
RTECS NUMBER
: DV8753000
CHEMICAL NAME
: 3,3',4,4'-Biphenyltetramine, tetrahydrochloride
CAS REGISTRY NUMBER
: 7411-49-6
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C12-H14-N4.4Cl-H
MOLECULAR WEIGHT
: 360.14
WISWESSER LINE NOTATION : ZR BZ DR CZ DZ &GH 4
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* 3,3'-Diaminobenzidine tetrahydrochloride
* 3,3',4,4'-Tetraaminobiphenyl tetrahydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to
the
National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial
Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 260 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(2),325,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 260 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(2),325,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 520 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(2),325,1978
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIAMINOBENZOIC ACID DIHYDROCHLORIDE (3,5-)
RTECS NUMBER
: DG6240000
CHEMICAL NAME
: Benzoic acid, 3,5-diamino-, dihydrochloride
CAS REGISTRY NUMBER
: 618-56-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C7-H8-N2-O2.2Cl-H
MOLECULAR WEIGHT
: 225.09
WISWESSER LINE NOTATION : ZR CZ EVQ &GH 2
SYNONYMS/TRADE NAMES :
* 3,5-Diaminobenzoic acid dihydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intravenous
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00464
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIAMINODECANE (1,10-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
:
:
:
:
:
:
:
:
:
:
HD7175000
1,10-Decanediamine
646-25-3
1738591
4-04-00-01368 (Beilstein Handbook Reference)
199701
3
C10-H24-N2
172.36
Z10Z
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 90,260,1947
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 4,377,1952
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIAMINODIPHENYL SULFONE (4,4'-)
RTECS NUMBER
: BY8925000
CHEMICAL NAME
: Aniline, 4,4'-sulfonyldiCAS REGISTRY NUMBER
: 80-08-0
BEILSTEIN REFERENCE NO. : 0788055
REFERENCE
: 4-13-00-01306 (Beilstein Handbook Reference)
LAST UPDATED
: 199904
DATA ITEMS CITED
: 47
MOLECULAR FORMULA
: C12-H12-N2-O2-S
MOLECULAR WEIGHT
: 248.32
WISWESSER LINE NOTATION : ZR DSWR DZ
COMPOUND DESCRIPTOR
: Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Avlosulfon
* Avlosulphone
* Benzenamine, 4,4'-sulfonylbis* Bis(p-aminophenyl) sulfone
* Bis(4-aminophenyl) sulfone
* Bis(p-aminophenyl)sulphone
* Bis(4-aminophenyl)sulphone
* Croysulfone
* Croysulphone
* DADPS
* Dapson
* Dapsone
* Dapsonum
* DDS
* DDS (pharmaceutical)
* Diaminodifenilsulfona
* 4,4-Diaminodifenylsulfon
* Diamino-4,4'-diphenyl sulfone
* p,p'-Diaminodiphenyl sulfone
* 4,4'-Diaminodiphenyl sulfone
* Diamino-4,4'-diphenyl sulphone
* p,p-Diaminodiphenyl sulphone
* 4,4'-Diaminodiphenyl sulphone
* Di(p-aminophenyl) sulfone
* Di(4-aminophenyl)sulfone
* Di(p-aminophenyl)sulphone
* Di(4-aminophenyl)sulphone
* Diaphenylsulfon
* Diaphenylsulfone
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Diaphenylsulphon
Diaphenylsulphone
Diphenasone
Diphone
Disulone
DSS
Dubronax
Dumitone
Eporal
1358F
F 1358
Metabolite C
NCI-C01718
Novophone
NSC-6091
NSC 6091D
Sulfona
Sulfona-Mae
Sulfone UCB
1,1'-Sulfonylbis(4-aminobenzene)
4,4'-Sulfonylbisaniline
p,p-Sulfonylbisbenzamine
4,4'-Sulfonylbisbenzamine
p,p-Sulfonylbisbenzenamine
4,4'-Sulfonylbisbenzenamine
p,p'-Sulfonyldianiline
4,4'-Sulfonyldianiline
Sulphadione
1,1'-Sulphonylbis(4-aminobenzene)
p,p-Sulphonylbisbenzamine
4,4'-Sulphonylbisbenzamine
p,p-Sulphonylbisbenzenamine
4,4'-Sulphonylbisbenzenamine
Sulphonyldianiline
p,p-Sulphonyldianiline
4,4'-Sulphonyldianiline
Sumicure S
Tarimyl
Udolac
WR 448
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 37500 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
Gastrointestinal - nausea or vomiting
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston
St.,
Baltimore, MD 21202) V.11985- Volume(issue)/page/year: 13,127,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 112 mg/kg/4W-I
TOXIC EFFECTS :
Behavioral - muscle weakness
Cardiac - pulse rate increase, without fall in BP
Blood - oxidant related (GPD deficient) anemia
REFERENCE :
CEDEDE Clinical and Experimental Dermatology. (Blackwell Scientific Pub.
Ltd., POB 88, Oxford, UK) V.11976- Volume(issue)/page/year:
20,155,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 300 mg/kg/21W-I
TOXIC EFFECTS :
Blood - eosinophilia
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1Volume(issue)/page/year: 343,860,1994
1823-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
19,1061,1982/1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year:
214,215,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 18 gm/kg/15Y
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Musculoskeletal - joints
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK)
Volume(issue)/page/year:
1,78,1978
V.1-
1857-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 28 mg/kg
TOXIC EFFECTS :
Blood - agranulocytosis
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
286,1244,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 36 mg/kg
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke,
Hants., RG 21 2XS, UK) V.11981- Volume(issue)/page/year: 2,507,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 5,213,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 196 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.41898- Volume(issue)/page/year: 183,36,1970
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
250 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTUA4 American Review of Tuberculosis. (New York, NY) V.1-70, 1917-54.
For publisher information, see ARDSBL. Volume(issue)/page/year:
60,62,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 313 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
48,336,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTUA4 American Review of Tuberculosis. (New York, NY) V.1-70, 1917-54.
For publisher information, see ARDSBL. Volume(issue)/page/year:
60,62,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
48,336,1952
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 357 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANPSAI Archives of Neurology and Psychiatry. (Chicago, IL) V.1-64,
1919-50. For publisher information, see ARNEAS.
Volume(issue)/page/year:
54,319,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 22,967,1991
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - domestic
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - muscle contraction or spasticity
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 5,565,1950
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(9),23,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6750 mg/kg/45D-C
TOXIC EFFECTS :
Related to Chronic Data - death
(V/O
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-20,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 910 mg/kg/26W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(9),23,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 44 mg/m3/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Kidney, Ureter, Bladder - proteinuria
Nutritional and Gross Metabolic - changes in chlorine
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 14,118,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ug/m3/24H/13W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(5),3,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Blood - pigmented or
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
150 mg/kg/3D-I
nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.11913Volume(issue)/page/year: 57,1028,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10800 mg/kg/45D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-20,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1890 mg/kg/30D-I
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536152
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 gm/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Blood - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-20,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1312 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,3069,1973
TYPE OF TEST
ROUTE OF EXPOSURE
: TD - Toxic dose (other than lowest)
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 39 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Blood - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-20,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 52 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - changes in spleen
Musculoskeletal - tumors
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 25,123,1980
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 78450 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - thyroid tumors
REFERENCE :
ALEPA8 Acta Leprologica. (3, pl. Claparede, 1205 Geneva, Switzerland)
No.11960- Volume(issue)/page/year: 53,11,1973
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 21840 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Blood - tumors
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
25,619,1987
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
DOSE
: 2100 mg/kg
SEX/DURATION
: male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 81,259,1987
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 4 mg/L
REFERENCE :
IJLEAG International Journal of Leprosy and Other Mycobacterial Diseases.
(POB 1097, Bloomfield, NJ 07003) V.11933- Volume(issue)/page/year:
43,41,1975
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,59,1980
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 24,59,1980
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,185,1987
TOXICOLOGY REVIEW
IJDEBB International Journal of Dermatology. (J.B. Lippincott Co., E.
Washington Sq., Philadelphia, PA 19105) V.91970Volume(issue)/page/year: 14,494,1975
TOXICOLOGY REVIEW
JSIRAC Journal of Scientific and Industrial Research. (Pub. &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110012, India) V.1-4,
1942-45;
V.22-
1963-
Volume(issue)/page/year: 34,521,1975
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-FINLAND;Carcinogen JAN 1993
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0798
No. of Facilities: 24 (estimated)
No. of Industries: 2
No. of Occupations: 8
No. of Employees: 1510 (estimated)
No. of Female Employees: 198 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);clear evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-20,1977
NCI Carcinogenesis Bioassay (feed);no evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-20,1977
DIAMINODIPHENYLMETHANE (4,4'-)
RTECS NUMBER
: BY5425000
CHEMICAL NAME
: Aniline, 4,4'-methylenediCAS REGISTRY NUMBER
: 101-77-9
BEILSTEIN REFERENCE NO. : 0474706
REFERENCE
: 4-13-00-00390 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 51
MOLECULAR FORMULA
: C13-H14-N2
MOLECULAR WEIGHT
: 198.29
WISWESSER LINE NOTATION : ZR D1R DZ
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* 4-(4-Aminobenzyl)aniline
* Ancamine TL
* Araldite hardener 972
* Avaldite HT 972
* Benzenamine, 4,4'-methylenebis* Bis-p-aminofenylmethan
* Bis(p-aminophenyl)methane
* Bis(4-aminophenyl)methane
* Curithane
* Dadpm
* DAPM
* p,p'-Diaminodifenylmethan
* 4,4'-Diaminodiphenylmethan
* Diaminodiphenylmethane
* p,p'-Diaminodiphenylmethane
* Di-(4-aminophenyl)methane
* Dianilinomethane
* 4,4'-Diphenylmethanediamine
* Epicure DDM
* Epikure DDM
* HT 972
* Jeffamine AP-20
* Methylenebis(aniline)
* 4,4'-Methylenebisaniline
* 4,4'-Methylenebis(benzeneamine)
* Methylenedianiline
* p,p'-Methylenedianiline
* 4,4'-Methylenedianiline
* 4,4-Methylenedianiline
* Sumicure M
* Tonox
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,481,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 8420 ug/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy)
Liver - jaundice, other or unclassified
Liver - other changes
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
1,514,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 517 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539752
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 193 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.11913- Volume(issue)/page/year:
57,247,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 745 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 74 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 14,677,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 11,185,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 58,167,1907
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555064
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - guinea pig
260 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,393,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16800 mg/kg/40W-C
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
48,145,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6972 mg/kg/12W-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
APPFAR Acta Poloniae Pharmaceutica (English Translation). Translation of
APPHAX. (Warsaw, Poland) V.20-29, 1963-72. Discontinued.
Volume(issue)/page/year: 26,352,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 456 mg/kg/15W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - interstitial nephritis
Blood - normocytic anemia
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 11,367,1991
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 320 mg/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 219,1162,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1410 mg/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.11913- Volume(issue)/page/year:
57,247,1970
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 250 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
67,123,1979
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 370 umol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 2,1317,1981
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
368,59,1996
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
204,683,1988
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Sister chromatid exchange
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 9 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
108,225,1983
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.81 mg/m3 (0.1 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,347,1986
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 39,347,1986
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DE85-017376
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 ppm (0.8 mg/m3);Skin JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-BELGIUM:TWA 0.1 ppm (0.81 mg/m3);Skin;Carcinogen JAN 1993
OEL-DENMARK: TWA 0.1 ppm (0.8 mg/m3), JAN1999
OEL-GERMANY;Skin;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.8 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.8 mg/m3);Skin;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.4 mg/m3, Skin, 2B Carcinogen, JAN1999
OEL-UNITED KINGDOM:TWA 0.1 ppm (0.8 mg/m3);STEL 0.5 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 4,4'-METHYLENEDIANILINE-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83609
No. of Facilities: 363 (estimated)
No. of Industries: 16
No. of Occupations: 27
No. of Employees: 9163 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83609
No. of Facilities: 741 (estimated)
No. of Industries: 25
No. of Occupations: 30
No. of Employees: 15170 (estimated)
No. of Female Employees: 3407 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN 8, 1976 AND BULLETIN 47, 1986
NIOSH Analytical Method, 1994: 4,4'-Methylenedianiline, 5029
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
OSHA ANALYTICAL METHOD #ID-57
DIAMINODODECANE (1,12-)
RTECS NUMBER
: JR2200000
CHEMICAL NAME
: 1,12-Dodecanediamine
CAS REGISTRY NUMBER
: 2783-17-7
BEILSTEIN REFERENCE NO. : 1742765
REFERENCE
: 4-04-00-01376 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C12-H28-N2
MOLECULAR WEIGHT
: 200.42
WISWESSER LINE NOTATION : Z12Z
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,12-Diaminododecane
* Dodecamethylenediamine
* 1,12'-Dodecamethylenediamine
* 1,12'-Dodecanediamine
* Dodecyldiamine
* 1,12'-Dodecylenediamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,92,1990
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 670 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,92,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1088 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(5),18,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(5),18,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(5),18,1978
(V/O
(V/O
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 54600 ug/kg/26W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Blood - change in clotting factors
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(5),18,1978
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINOHEXANE (1,6-)
RTECS NUMBER
: MO1180000
CHEMICAL NAME
: 1,6-Hexanediamine
CAS REGISTRY NUMBER
: 124-09-4
BEILSTEIN REFERENCE NO. : 1098307
REFERENCE
: 4-04-00-01320 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 23
MOLECULAR FORMULA
: C6-H16-N2
MOLECULAR WEIGHT
: 116.24
WISWESSER LINE NOTATION : Z6Z
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* 1,6-Diaminohexane
* Hexamethylenediamine
* 1,6-Hexamethylenediamine
* 1,6-Hexanediamine
* HMDA
* NCI-C61405
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,417,1977
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >950 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-1090-0979
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research
and Development, Progress Report. Volume(issue)/page/year:
NDCrc-132,SEP1942
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 43(11),110,1978
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,74,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02313
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.142,417,1977
1959-
Volume(issue)/page/year:
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/m3/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Blood - hemorrhage
Related to Chronic Data - death
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
27,1,1970
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 215 mg/m3/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 9,504,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 360 ug/m3/17W-I
TOXIC EFFECTS :
Cardiac - other changes
Vascular - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 23(11),71,1958
(V/O
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 7,259,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1840 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 7,259,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 77 gm/kg
SEX/DURATION
: multigeneration
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 16,490,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 66500 mg/kg
SEX/DURATION
: multigeneration
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 16,490,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 414 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,237,1983
*** REVIEWS ***
ACGIH TLV-TWA 2.3 mg/m3 (0.5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3;Skin JAN 1993
OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83335
No. of Facilities: 62 (estimated)
No. of Industries: 4
No. of Occupations: 9
No. of Employees: 1093 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83335
No. of Facilities: 879 (estimated)
No. of Industries: 9
No. of Occupations: 24
No. of Employees: 31036 (estimated)
No. of Female Employees: 4686 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINOHYDROXYPROPANE TETRAACETIC ACID (1,3,2-)
RTECS NUMBER
: AI2930000
CHEMICAL NAME
: Acetic acid,
((2-hydroxy-1,3-trimethylene)dinitrilo)tetraCAS REGISTRY NUMBER
: 3148-72-9
BEILSTEIN REFERENCE NO. : 1716800
REFERENCE
: 4-04-00-02459 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C11-H18-N2-O9
MOLECULAR WEIGHT
: 322.31
WISWESSER LINE NOTATION : QV1N1VQ1YQ1&N1VQ1V1Q
SYNONYMS/TRADE NAMES :
* Acetic acid, diaminopropanoltetra* Acetic acid, ((2-hydroxytrimethylene)dinitrilo)tetra* DHPTA
* Diaminopropanol tetra acetic acid
* DPTA
* DTA
* Glycine, N,N'-(2-hydroxy-1,3-propanediyl)bis(N-(carboxymethyl)* ((2-Hydroxytrimethylene)dinitrilo)tetraacetic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3112
No. of Facilities: 2954 (estimated)
No. of Industries: 33
No. of Occupations: 13
No. of Employees: 11898 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3112
No. of Facilities: 17 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 36 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINOOCTANE (1,8-)
RTECS NUMBER
: RG8841500
CHEMICAL NAME
: 1,8-Octanediamine
CAS REGISTRY NUMBER
: 373-44-4
BEILSTEIN REFERENCE NO. : 1735426
REFERENCE
: 3-04-00-00612 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C8-H20-N2
MOLECULAR WEIGHT
: 144.30
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,8-Diaminooctane
* Octamethylenediamine
* 1,8-Octamethylenediamine
* 1,8-Octylenediamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,751,1992
TYPE OF TEST
ROUTE OF EXPOSURE
: Standard Draize test
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,751,1992
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,751,1992
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINOPHENOL DIHYDROCHLORIDE (2,4-)
RTECS NUMBER
: SK7600000
CHEMICAL NAME
: Phenol, 2,4-diamino-, dihydrochloride
CAS REGISTRY NUMBER
: 137-09-7
LAST UPDATED
: 199904
DATA ITEMS CITED
: 15
MOLECULAR FORMULA
: C6-H8-N2-O.2Cl-H
MOLECULAR WEIGHT
: 197.08
WISWESSER LINE NOTATION : ZR CZ DQ &GH 2
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acrol
* Amidol
* 2,4-Diaminophenol hydrochloride
* Dianol
* NCI-C60026
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 240 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 13,330,1994
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale.
(Brussels,
Belgium) V.18-31, 1947-65. For publisher information, see PTEUA6.
Volume(issue)/page/year: 22,1,1952
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6500 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-401,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg/4D-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555385
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg/16D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-401,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 325 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-401,1992
(Research
(Research
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 330 ng/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9,143,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2516
No. of Facilities: 809 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 6638 (estimated)
No. of Female Employees: 4211 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (gavage);some evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-401,1992
NTP Carcinogenesis Studies (gavage);no evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-401,1992
(Research
(Research
DIAMINOPHENYLTRIAZINE
RTECS NUMBER
: XY7000000
CHEMICAL NAME
: s-Triazine, 2,4-diamino-6-phenylCAS REGISTRY NUMBER
: 91-76-9
BEILSTEIN REFERENCE NO. : 0153223
REFERENCE
: 4-26-00-01244 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C9-H9-N5
MOLECULAR WEIGHT
: 187.23
WISWESSER LINE NOTATION : T6N CN ENJ BZ DZ FR
SYNONYMS/TRADE NAMES :
* Benzoguanamine
* Benzoguanimine
* 2,4-Diamino-6-phenyl-s-triazine
* 4,6-Diamino-2-phenyl-s-triazine
* ENT 60118
* 2-Phenyl-4,6-diamino-s-triazine
* 2-Phenyl-4,6-diamino-1,3,5-triazine
* 1,3,5-Triazine-2,4-diamine, 6-phenyl* USAF RH-5
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIAMINOPROPANE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* 1,2-Diaminopropane
* 2,3-Diaminopropane
* Propylenediamine
:
:
:
:
:
:
:
:
:
:
:
TX6650000
1,2-Propanediamine
78-90-0
0605274
4-04-00-01255 (Beilstein Handbook Reference)
199709
12
C3-H10-N2
74.15
ZY1&1Z
Primary Irritant
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 435 mg
REACTION SEVERITY
: Severe
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/12/1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
REFERENCE :
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
5 mg/24H
Severe
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,441,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 87 mg
REACTION SEVERITY
: Severe
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/12/1969
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 750 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,441,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/12/1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 909 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin,
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 17,59,1915
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 593 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 97,1117,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83465
No. of Facilities: 118 (estimated)
No. of Industries: 7
No. of Occupations: 13
No. of Employees: 2614 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83465
No. of Facilities: 122 (estimated)
No. of Industries: 3
No. of Occupations: 8
No. of Employees: 8346 (estimated)
No. of Female Employees: 3070 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIAMINOPROPANE (1,3-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
TX6825000
1,3-Propanediamine
109-76-2
0605277
4-04-00-01258 (Beilstein Handbook Reference)
199710
9
C3-H10-N2
74.15
Z3Z
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,3-Diaminopropane
* DAP
* alpha,omega-Propanediamine
* 1,3-Propylenediamine
* TMEDA
* Trimethylenediamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg
REACTION SEVERITY
: Severe
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/28/1963
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 mg
REACTION SEVERITY
: Severe
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/28/1963
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 350 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 296 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 97,1117,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 264 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 28,237,1983
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0123
No. of Facilities: 61 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 2916 (estimated)
No. of Female Employees: 1961 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINOPYRIDINE (2,6-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
US7570000
Pyridine, 2,6-diamino141-86-6
0108513
5-22-11-00255 (Beilstein Handbook Reference)
199712
4
C5-H7-N3
109.15
T6NJ BZ FZ
Mutagen
SYNONYMS/TRADE NAMES :
* 2,6-Diaminopyridine
* 2,6-Pyridinediamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 8,296,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00146
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ug/plate
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(94),28,1976
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIAMINOTOLUENE (2,4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: XS9625000
: Toluene-2,4-diamine
: 95-80-7
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
2205839
4-13-00-00235 (Beilstein Handbook Reference)
199907
67
C7-H10-N2
122.19
ZR CZ D1
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* 3-Amino-p-toluidine
* 5-Amino-o-toluidine
* 1,3-Benzenediamine, 4-methyl* Benzofur MT
* Brown for Fur T
* C.I. 76035
* C.I. Oxidation Base 20
* C.I. Oxidation Base 35
* C.I. Oxidation Base 200
* Developer 14
* Developer B
* Developer DB
* Developer DBJ
* Developer MC
* Developer MT
* Developer MT-CF
* Developer MTD
* Developer T
* 1,3-Diamino-4-methylbenzene
* 2,4-Diamino-1-methylbenzene
* 2,4-Diaminotoluen
* 2,4-Diaminotoluene
* 2,4-Diamino-1-toluene
* 2,4-Diaminotoluol
* Eucanine GB
* Fouramine
* Fouramine J
* Fourrine 94
* Fourrine M
* 4-Methyl-1,3-benzenediamine
* 4-Methyl-m-phenylenediamine
* MTD
* Nako TMT
* NCI-C02302
* Pelagol Grey J
* Pelagol J
* Pontamine developer TN
* RCRA waste number U221
* Renal MD
* TDA
* Tertral G
* 2,4-Tolamine
* m-Toluenediamine
* m-Toluylendiamin
*
*
*
*
*
*
m-Toluylenediamine
m-Tolyenediamine
m-Tolylenediamine
Tolylene-2,4-diamine
2,4-Tolylenediamine
Zoba GKE
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,477,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,477,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 325 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 3(1-2),149,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie.
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 17,59,1915
(Berlin,
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 3(1-2),149,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington,
DC)
Volume(issue)/page/year: 271,56,1941
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie.
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 17,59,1915
(Berlin,
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2100 mg/kg/90W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,1107,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8050 mg/kg/101W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-162,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 17 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-162,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5030 mg/kg/84W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-162,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9000 mg/kg/36W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
29,1137,1969
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8400 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
70,453,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 16800 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
70,453,1979
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1260 mg/kg
SEX/DURATION
: male 10 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 16,753,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1260 mg/kg
SEX/DURATION
: male 10 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 16,763,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 210 mg/kg
SEX/DURATION
: male 1 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 25,435,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1200 mg/kg
SEX/DURATION
: female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Newborn - live birth index (measured after
birth)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
7,29,1987
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 mg/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 ug/plate
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 76,291,1986
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 60 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
192,239,1987
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 mmol/L
REFERENCE :
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation,
see
EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11949-
Volume(issue)/page/year: 31,11,1979
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
56,31,1977
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 15200 mmol/L/3D
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
48,181,1977
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
127,107,1984
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
49,1075,1989
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 12,2233,1991
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 84 mg/kg/3W (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
367,209,1996
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: DNA damage
: Intraperitoneal
: Rodent - rat
DOSE/DURATION
: 37 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 6,1285,1985
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 150 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,553,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
315,147,1994
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION
: 70 mg/kg
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 76,291,1986
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 240 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
391,201,1997
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 111 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
91,75,1981
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 9 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
108,225,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 198 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
135,115,1984
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 500 ug/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
3,45,1977
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 6 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
265,45,1992
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 4 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
265,45,1992
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
135,115,1984
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 16,83,1978
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 16,83,1978
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-FINLAND;Carcinogen JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993
OEL-SWEDEN;Carcinogen JAN 1993
OEL-SWITZERLAND;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 0.04 mg/m3, MAC(STEL) 0.1 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO TOLUENEDIAMINE-air:CA lowest feasible concentration
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5386
No. of Facilities: 130 (estimated)
No. of Industries: 6
No. of Occupations: 15
No. of Employees: 8511 (estimated)
No. of Female Employees: 396 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Sperm
morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.147,27009,82
1936-
Volume(issue)/page/year:
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN 53, DECEMBER 1989
NIOSH Analytical Method, 1994: 2,4-Toluenediamine, 5516
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-162,1979
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
OSHA ANALYTICAL METHOD #ID-65
DIAMINOTOLUENE (2,5-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
XS9700000
Toluene-2,5-diamine
95-70-5
0774521
4-13-00-00246 (Beilstein Handbook Reference)
199710
18
C7-H10-N2
122.19
ZR DZ B1
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 4-Amino-2-methylaniline
* 1,4-Benzenediamine, 2-methyl* C.I. 76042
* 2,5-Diaminotoluene
* 2-Methyl-1,4-benzenediamine
* 2-Methyl-p-phenylenediamine
* p-Toluenediamine
* p-Toluylendiamine
* Toluylene-2,5-diamine
* p,m-Tolylenediamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 12500 ug/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 15,607,1977
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 102 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Skin and Appendages - hair
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 15,607,1977
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 625 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin,
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 17,59,1915
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 222 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie.
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 17,59,1915
(Berlin,
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 3600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIDHAN Journal of Industrial Hygiene.
(Cambridge, MA)
V.1-17, 1919-35.
For
publisher information, see AEHLAU.
Volume(issue)/page/year: 13,87,1931
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1400 mg/kg/14D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Immunological Including Allergic - decrease in humoral immune response
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 17,401,1994
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 72,2423,1975
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
136,255,1984
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
136,255,1984
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 16,97,1978
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 16,97,1978
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-human
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAMINOTOLUENE (3,4-)
RTECS NUMBER
: XS9820000
CHEMICAL NAME
: Toluene-3,4-diamine
CAS REGISTRY NUMBER
: 496-72-0
BEILSTEIN REFERENCE NO. : 0507965
REFERENCE
: 4-13-00-00260 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C7-H10-N2
MOLECULAR WEIGHT
: 122.19
WISWESSER LINE NOTATION : ZR BZ D1
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 1,2-Benzenediamine, 4-methyl* 3,4-Diaminotoluene
* 3,4-Toluylenediamine
* 3,4-Tolylenediamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin,
Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.
Volume(issue)/page/year: 17,59,1915
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 333 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11(Suppl 12),1,1988
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 488 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
43,249,1980
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
91,75,1981
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIANISIDINE DIHYDROCHLORIDE (ORTHO-)
RTECS NUMBER
: DD1050000
CHEMICAL NAME
: Benzidine, 3,3'-dimethoxy-, dihydrochloride
CAS REGISTRY NUMBER
: 20325-40-0
LAST UPDATED
: 199904
DATA ITEMS CITED
: 18
MOLECULAR FORMULA
: C14-H16-N2-O2.2Cl-H
MOLECULAR WEIGHT
: 317.24
WISWESSER LINE NOTATION : 1OR BZ ER DZ CO1 &GH 2
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* (1,1'-Biphenyl)-4,4'-diamine, 3,3-dimethoxy-, dihydrochloride
* C.I. Disperse Black 6 dihydrochloride
* o-Dianisidine dihydrochloride
* 3,3'-Dimethoxy-4,4'-diaminobiphenyl dihydrochloride
* 3,3'-Dimethoxybenzidine dihydrochloride
* 3,3'-Dimethoxy-(1,1-biphenyl)-4,4'-diamine dihydrochloride
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9100 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-372,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8271 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 59,297,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9009 mg/kg/39W-C
TOXIC EFFECTS :
Blood - other changes
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-372,1990
(Research
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1040 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
41,985,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5760 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 25(7),43,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1152 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 25(7),43,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 11 gm/kg/51W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Skin and Appendages - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
41,985,1968
(Washington, DC)
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6497 mg/kg/91W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-372,1990
(Research
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
136,33,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 nmol/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10,263,1987
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 50 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 33 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),37,1988
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 500 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-372,1990
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 50 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-372,1990
(Research
(Research
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO o-DIANISIDINE-BASED DYES-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7012
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 489 (estimated)
No. of Female Employees: 300 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Studies (gavage);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-372,1990
DIASTASE OF MALT
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
BU7430000
Amylase
9000-92-4
199710
11
Drug
(Research
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Amylopol P
Amzyme TX 8
Dabiase K-27
Diastase
Glycogenase
JP-Diastase
Kleistase M 20
Kleistase TU 20
Malt diastase
Maltin
Mylase 100
Neospitase K
Rapidase 2M
Termozym
Termoamylase
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 10,632,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 10,632,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 10,632,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 10,632,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 10,632,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 10,632,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 37,608,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80401
No. of Facilities: 103 (estimated)
No. of Industries: 2
No. of Occupations: 6
No. of Employees: 3015 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80401
No. of Facilities: 812 (estimated)
No. of Industries: 7
No. of Occupations: 19
No. of Employees: 14806 (estimated)
No. of Female Employees: 8114 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAZABICYCLOOCTANE (1,4-)
RTECS NUMBER
: HM0354200
CHEMICAL NAME
: 1,4-Diazabicyclo(2,2,2)octane
CAS REGISTRY NUMBER
: 280-57-9
LAST UPDATED
: 199710
DATA ITEMS CITED
: 11
MOLECULAR FORMULA
: C6-H12-N2
MOLECULAR WEIGHT
: 112.20
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Bicyclo(2,2,2)-1,4-diazaoctane
* Dabco
* Dabco crystal
* Dabco EG
* Dabco 33LV
* Dabco R-8020
* Dabco S-25
* D 33LV
* 1,4-Ethylenepiperazine
* TED
* TEDA
* Texacat TD 100
* Thancat TD 33
* Triethylenediamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2500 ug
REACTION SEVERITY
: Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
4,522,1962
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
:
:
:
:
:
Standard Draize test
Administration into the eye
Rodent - rabbit
25 mg
Moderate
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
4,522,1962
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.11955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(5),67,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(5),67,1980
(V/O
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4680 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(5),67,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0905
No. of Facilities: 334 (estimated)
No. of Industries: 9
No. of Occupations: 15
No. of Employees: 1710 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0905
No. of Facilities: 1104 (estimated)
No. of Industries: 23
No. of Occupations: 30
No. of Employees: 33913 (estimated)
No. of Female Employees: 5787 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIAZALD
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
XT5950000
p-Toluenesulfonamide, N-methyl-N-nitroso80-11-5
2214345
4-11-00-00478 (Beilstein Handbook Reference)
199701
8
C8-H10-N2-O3-S
214.26
ONN1&SWR D1
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzenesulfonamide, N,4-dimethyl-N-nitroso* Diazald
* Diazale
* Methylnitroso-p-toluenesulfonamide
* N-Methyl-N-nitroso-p-toluenesulfonamide
* N-Nitroso-N-methyl-4-tolylsulfonamide
* Toluene-p-sulfonylmethylnitrosamide
* p-Tolylsulfonyl-methyl-nitrosamid
(V/O
* p-Tolylsulfonylmethylnitrosamide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.11913- Volume(issue)/page/year:
48,165,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 19 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
30,11,1970
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
30,11,1970
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 14 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Bacteria - Escherichia coli
: 14 umol/L
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 2330 umol/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
144,177,1985
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBENZ(A,H)ANTHRACENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
HN2625000
Dibenz(a,h)anthracene
53-70-3
199907
90
C22-H14
278.36
L G6 D6 B666J
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 1,2:5,6-Benzanthracene
* DB(a,h)A
* 1,2,5,6-Dba
* 1,2,5,6-Dibenzanthraceen
* 1,2:5,6-Dibenzanthracene
* 1,2:5,6-Dibenz(a)anthracene
* Dibenzo(a,h)anthracene
* 1,2:5,6-Dibenzoanthracene
* RCRA waste number U063
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Intravenous
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
1,225,1940
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 31(7),12,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4160 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JPBAA7 Journal of Pathology and Bacteriology. (London, UK)
1892-1968. For publisher information, see JPTLAS.
Volume(issue)/page/year:
49,21,1939
(V/O
V.1-96,
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 mg/kg/50W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
14JTAF "Mycotoxins in Foodstuffs, Proceedings of the Symposium held at
the
Massachusetts Institute of Technology, 1964," Wogan, G.N., ed.,
Cambridge,
MA, MIT Press, 1965 Volume(issue)/page/year: -,275,1965
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
445 ug/kg
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 11,1721,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11878- Volume(issue)/page/year:
54,1158,1939
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
11,212,1957
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Multiple routes
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg/12D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11878- Volume(issue)/page/year:
52,637,1937
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 250 mg/kg/24D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
AKBNAE Arkhiv Biologicheskikh Nauk. Archives of Biological Sciences.
For
French translation, see ASBUAN. (Moscow, USSR) V.1-64, 1892-1941.
Discontinued. Volume(issue)/page/year: 51,112,1938
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
13,705,1952
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
32,905,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intrarenal
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 12 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
24,1969,1964
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1-
1925Volume(issue)/page/year: 16,287,1940
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 78 ug/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
3,503,1943
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4520 mg/kg/36W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Gastrointestinal - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
1,17,1940
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
Tumorigenic - tumors at site of application
REFERENCE :
AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40.
For
publisher information, see CNREA8. Volume(issue)/page/year: 36,201,1939
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 ug/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
20,1179,1960
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 32,765,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg/40W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
22,78,1962
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
Tumorigenic - tumors at site of application
REFERENCE :
BMBUAQ British Medical Bulletin. (Longman Group UK Ltd., Longman House,
Burnt Mill, Harlow, Essex CM20 2JE, UK) V.11943Volume(issue)/page/year: 14,147,1958
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 135 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 68,330,1948
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TD - Toxic dose (other than lowest)
Subcutaneous
Rodent - mouse
400 mg/kg/10W-I
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 2,500,1967
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 5 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
174,247,1986
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 25 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,53,1977
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 2 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,349,1991
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 2700 mg/L
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD
21264)
V.11916- Volume(issue)/page/year: 33,337,1948
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
EJGCA9 Egyptian Journal of Genetics and Cytology. (Egyptian Soc. of
Genetics, c/o Alexandria Univ., Faculty of Agriculture, Dept. of
Genetics,
Alexandria, Egypt) V.11972- Volume(issue)/page/year: 4,400,1975
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 2700 mg/L
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD
21264)
V.11916- Volume(issue)/page/year: 33,337,1948
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Neurospora crassa
DOSE/DURATION
: 500 ppm
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences.
Sciences, 2 E. 63rd St., New York, NY 10021) V.1Volume(issue)/page/year: 71,1072,1958
(New York Academy of
1877-
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Fish - salmon Testis
DOSE/DURATION
: 5 ug/1H (Continuous)
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,
Commerce
Way, Colchester, Essex CO2 8HP, UK) V.11906Volume(issue)/page/year:
110,159,1968
TYPE OF TEST
TEST SYSTEM
otherwise
: Unscheduled DNA synthesis
: Fish - not otherwise specified Cells - not
specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 86,399,1987
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Embryo
DOSE/DURATION
: 360 nmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions.
Ireland
Ltd., POB 85, Limerick, Ireland) V.122,257,1978
(Elsevier Scientific Pub.
1969-
Volume(issue)/page/year:
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 100 umol/L
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 86,399,1987
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,2091,1978
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 100 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,2621,1978
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 54 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
371,123,1996
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intratracheal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 25500 ug/kg/16H (Intermittent)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
326,147,1995
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
40,1157,1980
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 100 ug/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
51,799,1973
TYPE OF TEST
ROUTE OF EXPOSURE
: DNA adduct
: Intratracheal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 25560 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
312,165,1994
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intratracheal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 51150 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
312,165,1994
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
389,3,1997
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 4250 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
106,101,1982
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 500 ug/L
REFERENCE :
AETODY Advances in Modern Environmental Toxicology.
P.O. Box 252, Princeton Junction, NJ 08550) V.1Volume(issue)/page/year: 1,133,1980
(Senate Press, Inc.,
1980-
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 100 ug/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
52,1167,1974
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 6 umol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,947,1979
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 40 umol/kg
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 23,201,1979
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 1 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
4,389,1971/1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 1 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
4,389,1971/1972
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 510 nmol/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 9,349,1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 510 nmol/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 9,349,1972
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 56400 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,27,1977
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 2500 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
32,1391,1972
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 25 ug/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
7,143,1980
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 5 mg/L/24H
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
20,1297,1971
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 360 nmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
22,257,1978
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 5 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
20,1297,1971
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
4,389,1971/1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland)
4,389,1971/1972
V.1-
1969-
Volume(issue)/page/year:
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 1 mmol/L
REFERENCE :
PJACAW Proceedings of the Japan Academy. (Tokyo, Japan) V.21-53,
1945-77.
For publisher information, see PJABDW. Volume(issue)/page/year:
53,46,1977
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 900 mg/kg/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
66,65,1979
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
136,65,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 2 nmol/L
REFERENCE :
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.11959- Volume(issue)/page/year: 5,521,1962
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 3,178,1973
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,299,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.1-
1972-
Volume(issue)/page/year: 32,299,1983
IARC Cancer Review:Group 2A
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health.
(Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016)
23,6,1971
V.1-
1960-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
39,257,1977
TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 24,129,1983
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-GERMANY;Carcinogen JAN 1993
OEL-POLAND: TWA 0.004 mg/m3, JAN1999
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell
transform.-SA7/F344 rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-BALB/c-3T3; SHE-focus
assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-C3H/10T1/2; Cell
transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; N
crassa-forward mutation
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive/dose response: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Inconclusive: Cell transform.-mouse prostate;
In
vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC,
5506; by GC, 5515
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
DIBENZOTHIOPHENE
RTECS NUMBER
: HQ3490550
CHEMICAL NAME
: Dibenzothiophene
CAS REGISTRY NUMBER
: 132-65-0
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C12-H8-S
MOLECULAR WEIGHT
: 184.26
SYNONYMS/TRADE NAMES :
* 2,2'-Biphenylylene sulfide
* Dibenzo(b,d)thiophene
* Diphenylene sulfide
* 9-Thiafluorene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 470 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - coma
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 12,787,1989
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD - Lethal dose
Intraperitoneal
Rodent - mouse
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 4,378,1952
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7480 mg/kg/24W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Liver - changes in liver weight
Endocrine - changes in spleen weight
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,161,1942
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4832
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIBENZOYLMETHANE
RTECS NUMBER
: TZ1930000
CHEMICAL NAME
: 1,3-Propanedione, 1,3-diphenylCAS REGISTRY NUMBER
: 120-46-7
BEILSTEIN REFERENCE NO. : 0514910
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C15-H12-O2
MOLECULAR WEIGHT
: 224.27
SYNONYMS/TRADE NAMES :
* omega-Benzoylacetophenone
* 2-Benzoylacetophenone
*
*
*
*
*
Dibenzoylmethane
1,3-Diphenyl-1,3-propanedione
Karenzu DK2
Phenyl phenacyl ketone
Rhodiastab 83
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,28,1953
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4833
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBENZYLMETHYLENEDIAMINE (N,N'-)
RTECS NUMBER
: KV3325000
CHEMICAL NAME
: Ethylenediamine, N,N'-dibenzylCAS REGISTRY NUMBER
: 140-28-3
BEILSTEIN REFERENCE NO. : 0786668
REFERENCE
: 4-12-00-02321 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C16-H20-N2
MOLECULAR WEIGHT
: 240.38
WISWESSER LINE NOTATION : R1M2M1R
SYNONYMS/TRADE NAMES :
* Benzathine
* Benzatin
* 1,2-Bis(benzylamino)ethane
* DBED
* N,N'-Dibenzylethylenediamine
* USAF DO-53
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 388 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68.
For
publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBROMOACETOPHENONE (2,4-)
RTECS NUMBER
: AM6950000
CHEMICAL NAME
: Acetophenone, 2,4'-dibromoCAS REGISTRY NUMBER
: 99-73-0
BEILSTEIN REFERENCE NO. : 0607604
REFERENCE
: 4-07-00-00652 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C8-H6-Br2-O
MOLECULAR WEIGHT
: 277.96
WISWESSER LINE NOTATION : E1VR DE
SYNONYMS/TRADE NAMES :
* 4-Bromo(bromoacetyl)benzene
* Bromomethyl p-bromophenyl ketone
* Bromomethyl 4-bromophenyl ketone
* p-Bromophenacyl-8
* p-Bromophenacyl bromide
* 4-Bromophenacyl bromide
* alpha,p-Dibromoacetophenone
* alpha,4-Dibromoacetophenone
*
*
*
*
*
p,alpha-Dibromoacetophenone
omega,4-Dibromoacetophenone
2,4'-Dibromoacetophenone
4,alpha-Dibromoacetophenone
Ethanone, 2-bromo-1-(4-bromophenyl)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64;
V.18-19, 1968-69. For publisher information, see JNMDBO.
Volume(issue)/page/year: 11,137,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02407
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5162
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBROMOBUTANE (1,4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: EJ7565000
: Butane, 1,4-dibromo: 110-52-1
BEILSTEIN REFERENCE NO. : 1071199
REFERENCE
: 4-01-00-00267 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C4-H8-Br2
MOLECULAR WEIGHT
: 215.94
WISWESSER LINE NOTATION : E4E
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 1,4-Dibrombutan
* alpha,omega-Dibromobutane
* 1,4-Dibromobutane
* Tetramethylenebromide
* Tetramethylene dibromide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 14,668,1964
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
141,11,1984
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIBROMOBUTENE (1,4-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
EM4725000
2-Butene, 1,4-dibromo-, trans821-06-7
1719696
4-01-00-00791 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C4-H6-Br2
MOLECULAR WEIGHT
: 213.92
WISWESSER LINE NOTATION : E2U2E -T
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Dibromobutene
* trans-1,4-Dibromobut-2-ene
* 1,4-trans-Dibromobutene-2
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Severe
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,3,1961
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 62 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,9,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,9,1961
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBROMODIFLUOROMETHANE
RTECS NUMBER
: PA7525000
CHEMICAL NAME
: Methane, dibromodifluoroCAS REGISTRY NUMBER
: 75-61-6
BEILSTEIN REFERENCE NO. : 1732515
REFERENCE
: 4-01-00-00080 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 27
MOLECULAR FORMULA
: C-Br2-F2
MOLECULAR WEIGHT
: 209.83
WISWESSER LINE NOTATION : FXFEE
SYNONYMS/TRADE NAMES :
* Difluorodibromomethane
* Freon 12-B2
* Halon 1202
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 140 gm/m3/2H
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy)
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
Volume(issue)/page/year: 111,10,1975
*** REVIEWS ***
ACGIH TLV-TWA 858 mg/m3 (100 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 100 ppm (860 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,86,1971
OSHA PEL (Gen Indu):8H TWA 100 ppm (860 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 100 ppm (860 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
Volume(issue)/page/year:
OSHA PEL (Shipyard):8H TWA 100 ppm (860 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 100 ppm (860 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 100 ppm (860 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 100 ppm (860 mg/m3) JAN 1993
OEL-BELGIUM:TWA 100 ppm (858 mg/m3) JAN 1993
OEL-DENMARK: TWA 100 ppm (860 mg/m3), JAN1999
OEL-FINLAND:TWA 100 ppm (860 mg/m3);STEL 150 ppm (1290 mg/m3) JAN 1993
OEL-GERMANY:TWA 100 ppm (860 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 100 ppm (860 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 100 ppm (860 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 100 ppm (860 mg/m3);STEL 200 ppm JAN 1993
OEL-TURKEY:TWA 100 ppm (860 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 100 ppm (860 mg/m3);STEL 150 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIFLUORODIBROMOMETHANE-air:10H TWA 100 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 25515
No.
No.
No.
No.
of
of
of
of
Facilities: 40 (estimated)
Industries: 2
Occupations: 3
Employees: 2234 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 25515
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Difluorodibromomethane, 1012
DIBROMODODECANE (1,12-)
RTECS NUMBER
: JR2295000
CHEMICAL NAME
: Dodecane, 1,12-dibromoCAS REGISTRY NUMBER
: 3344-70-5
BEILSTEIN REFERENCE NO. : 1742763
REFERENCE
: 4-01-00-00503 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C12-H24-Br2
MOLECULAR WEIGHT
: 328.18
WISWESSER LINE NOTATION : E12E
SYNONYMS/TRADE NAMES :
* alpha,omega-Dibromododecane
* 1,12-Dibromododecane
* Dodecamethylene dibromide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#05707
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBROMOETHANE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
KH9275000
Ethane, 1,2-dibromo106-93-4
0605266
4-01-00-00158 (Beilstein Handbook Reference)
199907
164
C2-H4-Br2
187.88
E2E
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aadibroom
* Aethylenbromid
* Bromofume
* Bromuro di etile
* Celmide
* 1,2-Dibromaethan
* 1,2-Dibromoetano
* 1,2-Dibromoethane
* alpha,beta-Dibromoethane
* sym-Dibromoethane
* 1,2-Dibromoethane
* Dibromure d'ethylene
* 1,2-Dibroomethaan
* Dowfume 40
* Dowfume EDB
* Dowfume W-8
* Dowfume W-85
* Dowfume W-90
* Dowfume W-100
* Dwubromoetan
* EDB
* EDB-85
* ENT 15,349
* Ethylene bromide
* Ethylene dibromide
* 1,2-Ethylene dibromide
* Fumo-gas
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Glycol bromide
Glycol dibromide
Iscobrome D
NCI-C00522
Nefis
Nephis
Pestmaster
Pestmaster edb-85
RCRA waste number U067
Soilbrom
Soilbrom-40
Soilbrom-85
Soilbrom-90
Soilbrom-100
Soilbrome-85
Soilbrom-90EC
Soilfume
Unifume
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 1538 mg/2H
REACTION SEVERITY
: Severe
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene.
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 8,591,1938
(Berlin, Ger.)
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1%/14D
REACTION SEVERITY
: Severe
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1%
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Oral
: Human - woman
DOSE/DURATION
: 90 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,257,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 108 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,17,1978
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14300 mg/m3/30M
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and
Toxicology.
(Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i
Toksikologii,
Kiev, USSR) No.11964- Volume(issue)/page/year: 8,140,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und
Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
Volume(issue)/page/year:
-,-,1971/1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,288,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPCEAO Journal fuer Praktische Chemie. (Johann Ambrosius Barth Verlag,
Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.11834Volume(issue)/page/year: 320,133,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 146 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,
Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,38,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - body temperature decrease
Skin and Appendages - corrosive (after topical exposure)
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Rectal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Liver - hepatitis (hepatocellular necrosis), diffuse
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 34,223,1928
1909/10-
&
V.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 400 ppm/3H
TOXIC EFFECTS :
Nutritional and Gross Metabolic - conditioned vitamin deficiency
Lungs, Thorax, or Respiration - chronic pulmonary edema
Liver - hepatitis (hepatocellular necrosis), zonal
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 79 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 130 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
BPOSA4 British Poultry Science. (Longman Group UK Ltd., Longman House,
Burnt Mill, Harlow, Essex CM20 2JE, UK) V.11960Volume(issue)/page/year: 22,355,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 ppm/6H/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - pigmented or nucleated red blood cells
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 1,437,1981
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 ppm/7H/9D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 160 mg/kg/2D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
8,317,1981
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3 ppm/6H/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-210,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 50 ppm/7H/70D-I
TOXIC EFFECTS :
Behavioral - excitement
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 ppm/7H/4D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 50 ppm/7H/80D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 6,158,1952
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 162 mg/kg/7D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - pigmented or nucleated red blood cells
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
BPOSA4 British Poultry Science. (Longman Group UK Ltd., Longman House,
Burnt Mill, Harlow, Essex CM20 2JE, UK) V.11960Volume(issue)/page/year: 22,355,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 486 mg/kg/21D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
BPOSA4 British Poultry Science. (Longman Group UK Ltd., Longman House,
Burnt Mill, Harlow, Essex CM20 2JE, UK) V.11960Volume(issue)/page/year: 22,355,1981
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 540 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Vascular - tumors
Blood - tumors
REFERENCE :
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold
Spring
Harbor, NY 11724) V.11979- Volume(issue)/page/year: 5,279,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Vascular - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-201,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 16 gm/kg/53W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Gastrointestinal - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-86,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 40 ppm/6H/90W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
12,121,1981
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Administration onto the skin
Rodent - mouse
190 gm/kg/62W-I
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 63,1433,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 840 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
82,19,1986
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16 gm/kg/61W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-86,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 23 gm/kg/53W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Gastrointestinal - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-86,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 24 gm/kg/57W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-86,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6630 mg/kg/34W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-86,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 28 gm/kg/53W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Gastrointestinal - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-86,1978
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 ppm/7H/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - adrenal cortex tumors
Skin and Appendages - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
63,155,1982
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7000 mg/kg/47W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-86,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TD - Toxic dose (other than lowest)
: Oral
: Rodent - rat
DOSE/DURATION
: 18 gm/kg/44W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-86,1978
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Vascular - tumors
Lungs, Thorax, or Respiration - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-210,1982
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 ppm/6H/88W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Vascular - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-201,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE
: 88 ppb/8H
SEX/DURATION
: male 5 year(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
44,317,1987
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
50 mg/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,71,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 66670 ppb/4H
SEX/DURATION
: female 3-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,579,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 80 ppm/23H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
45,347,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 89 ppm/7H
SEX/DURATION
: male 10 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
49,97,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
39 ppm/7H
SEX/DURATION
: female 3 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
49,97,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 80 ppm/7H
SEX/DURATION
: female 3 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
49,97,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 25 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 27,27A,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 38 ppm/23H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
45,347,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 20 ppm/23H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
46,173,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 38 ppm/23H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
46,173,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 32 ppm/23H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB256-659
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 225 mg/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 16,687,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cattle
DOSE
: 40 mg/kg
SEX/DURATION
: male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 44,561,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cattle
DOSE
: 93600 ug/kg
SEX/DURATION
: male 12 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
JULRA7 Journal of Ultrastructure Research. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11975- Volume(issue)/page/year:
67,124,1979
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1600 ppm
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9,171,1987
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 20 uL/disc
REFERENCE :
BKNJA5 Biken Journal. (Research Institute for Microbial Diseases, Osaka
Univ., 3-1 Yamadaoka, Suita, Osaka-fu, Japan) V.11958Volume(issue)/page/year: 23,69,1980
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 350 nmol/tube
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
147,79,1985
TYPE OF TEST
TEST SYSTEM
: Mutation in microorganisms
: Bacteria - Escherichia coli
DOSE/DURATION
: 333 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mg/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
34,2576,1974
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 umol/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
46,277,1980
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 23 mmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
23,2345,1974
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 23 mmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
23,2345,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 2 uL/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
2,87,1981
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 14 ppm/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1182,243,1987
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
:
:
:
:
1964-
Volume(issue)/page/year:
Sex chromosome loss and nondisjunction
Oral
Insect - Drosophila melanogaster
300 umol/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 30,621,1974
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 2 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
68,59,1979
TYPE OF TEST
: Heritable translocation test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 25 ppm
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
23,208,1994
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Neurospora crassa
DOSE/DURATION
: 36000 ppm
REFERENCE :
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands) V.11972Volume(issue)/page/year:
11,223,1979
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 170 umol/L
REFERENCE :
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26,
1971-78. For publisher information, see IAPUDO.
Volume(issue)/page/year:
10,161,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 10 uL/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
2,87,1981
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 5300 nmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
4,17,1989
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Fish - not otherwise specified Lymphocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,555,1986
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Fish - not otherwise specified Lymphocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,555,1986
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
20,117,1992
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 mL/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
13,213,1981
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 2500 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
389,291,1997
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
97,188,1982
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
142,133,1985
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 75 mg/kg
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,
Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)
V.6(3/4)1978- Volume(issue)/page/year: 12,307,1984
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 12 ug/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,190,1981
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 15 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
49,5843,1989
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 16800 nmol/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,2438,1978
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 80 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,1129,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 80 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,1129,1982
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 20 umol/kg
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 141,723,1986
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 75 gm/kg
REFERENCE :
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21202) V.11952- Volume(issue)/page/year:
38,279,1978
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 50 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
97,359,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Sperm
DOSE/DURATION
: 1 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,489,1983
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 7,467,1986
TYPE OF TEST
: Mutation in mammalian somatic cells
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 30 ppm/10D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
405,193,1998
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 50 mg/kg/5D
REFERENCE :
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands) V.11972Volume(issue)/page/year:
11,223,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 45 mg/L/4H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
59,61,1979
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 75 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
58,118,1985
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 2,839,1981
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 39,1022,1980
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 55 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
163,193,1986
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 150 mg/L/4H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
59,61,1979
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 mg/kg
REFERENCE :
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946,
Leipzig
DDR-7010, Ger. Dem. Rep.) V.11881- Volume(issue)/page/year:
91,311,1972
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 400 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
90,183,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 500 mg/L
REFERENCE :
AETODY Advances in Modern Environmental Toxicology.
P.O. Box 252, Princeton Junction, NJ 08550) V.1Volume(issue)/page/year: 1,241,1980
(Senate Press, Inc.,
1980-
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 150 mg/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
4,432,1989
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
78,177,1980
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 5 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
78,177,1980
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
90,183,1981
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
11,243,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 10 mmol/L
REFERENCE :
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands) V.11972Volume(issue)/page/year:
11,223,1979
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Mammal - species unspecified
DOSE/DURATION
: 93600 ug/kg/12D (Intermittent)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 18,743,1980
*** REVIEWS ***
ACGIH TLV-Animal carcinogen (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,195,1977
IARC Cancer Review:Human Inadequate Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,204,1987
IARC Cancer Review:Group 2A
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,204,1987
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine.
(New York Academy
of
Medicine, 2 E. 103rd St., New York, NY 10029)
Volume(issue)/page/year: 54,413,1978
Ser 2: V.1-
1925-
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB83-184325
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 20 ppm (145 mg/m3) (skin)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,15,1973
OSHA PEL (Gen Indu):8H TWA 20 ppm;CL 30 ppm;Pk 50 ppm/5M/8H
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):CL 25 ppm (190 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 25 ppm (190 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 25 ppm (190 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.13 ppm (1 mg/m3) JAN 1993
OEL-AUSTRIA: Skin, Carcinogen, JAN1999
OEL-AUSTRALIA;Skin;Carcinogen JAN 1993
OEL-BELGIUM;Skin;Carcinogen JAN 1993
OEL-FINLAND:TWA 20 ppm (145 mg/m3);STEL 30 ppm;Skin;Carcinogen JAN 1993
OEL-GERMANY;Skin;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.8 mg/m3;Skin;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 20 ppm (155 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 25 ppm (190 mg/m3);Skin JAN 1993
OEL-SWEDEN;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.8 mg/m3);Skin;Carcinogen JAN 1993
OEL-THAILAND:TWA 20 ppm;STEL 30 ppm JAN 1993
OEL-TURKEY:TWA 25 ppm (190 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (8 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ETHYLENE DIBROMIDE-air:CA TWA 0.045 ppm;CL 0.13 ppm/15M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 23660
No. of Facilities: 438 (estimated)
No. of Industries: 5
No. of Occupations: 8
No. of Employees: 7921 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 23660
No. of Facilities: 496 (estimated)
No. of Industries: 7
No. of Occupations: 13
No. of Employees: 8559 (estimated)
No. of Female Employees: 792 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-forward mutation;
Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE;
Host-mediated
assay
EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; N
crassa-forward mutation
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Sperm
morphology-human
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: UDS in mouse germ cells
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN 3, 1975, AND BULLETIN 37, 1981
NIOSH Analytical Method, 1994: Ethylene dibromide, 1008
NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-86,1978
NTP Carcinogenesis Bioassay (inhalation);clear evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-210,1982
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
OSHA ANALYTICAL METHOD #02
DIBROMOETHYLENE (1,2-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Acetylene dibromide
* 2-Bromovinyl bromide
* 1,2-Dibromoethene
* sym-Dibromoethylene
* 1,2-Dibromoethylene
* Ethene, 1,2-dibromo-
KV7700000
Ethylene, 1,2-dibromo540-49-8
1719351
2-01-00-00164 (Beilstein Handbook Reference)
199806
2
C2-H2-Br2
185.86
Mutagen
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 15,101,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBROMOHEXANE (1,6-)
RTECS NUMBER
: MO1515000
CHEMICAL NAME
: Hexane, 1,6-dibromoCAS REGISTRY NUMBER
: 629-03-8
BEILSTEIN REFERENCE NO. : 1236322
REFERENCE
: 4-01-00-00354 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
6
C6-H12-Br2
244.00
E6E
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* alpha,omega-Dibromohexane
* 1,6-Dibromohexan
* 1,6-Dibromohexane
* Hexamethylene dibromide
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
20,563,1982
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Mild
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
20,573,1982
TYPE OF TEST
: Rinsed with water
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/30S
REACTION SEVERITY
: Mild
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
20,573,1982
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 14,668,1964
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
141,11,1984
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBROMOHYDROXYBENZALDEHYDE (3,5-)
RTECS NUMBER
: CU5609000
CHEMICAL NAME
: Benzaldehyde, 3,5-dibromo-2-hydroxyCAS REGISTRY NUMBER
: 90-59-5
BEILSTEIN REFERENCE NO. : 1424739
REFERENCE
: 3-08-00-00188 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C7-H4-Br2-O2
MOLECULAR WEIGHT
: 279.93
WISWESSER LINE NOTATION : VHR BQ CE EE
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Dalyde
* 3,5-Dibromo-2-hydroxybenzaldehyde
* 3,5-Dibromosalicylaldehyde
* Salicylaldehyde, 3,5-dibromo*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,
USA,
1255 Howard St., San Francisco, CA 94103)
Volume(issue)/page/year: 10,528,1962
V.6-
1958-
DIBROMOMETHANE
RTECS NUMBER
: PA7350000
CHEMICAL NAME
: Methane, dibromoCAS REGISTRY NUMBER
: 74-95-3
BEILSTEIN REFERENCE NO. : 0969143
REFERENCE
: 4-01-00-00078 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 16
MOLECULAR FORMULA
: C-H2-Br2
MOLECULAR WEIGHT
: 173.85
WISWESSER LINE NOTATION : E1E
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Methylene bromide
* Methylene dibromide
* RCRA waste number U068
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 108 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB85-143766
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,83,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - mouse
3738 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
4,354,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and
Environment Research, Toxicology Research Lab., Midland, MI 48640)
Volume(issue)/page/year: MSD-472
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and
Environment Research, Toxicology Research Lab., Midland, MI 48640)
Volume(issue)/page/year: MSD-472
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Rectal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 34,223,1928
V.1-
1909/10-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 333 mg/kg/28D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094)
V.1-
1966-
Volume(issue)/page/year: 41,515,1988
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ng/plate
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 24,590,1980
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 ug/plate
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 13,205,1987
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 13,205,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 10 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4051
No. of Facilities: 33 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 1065 (estimated)
No. of Female Employees: 452 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIBROMOMETHYLPROPANE (1,2:2-)
RTECS NUMBER
: TX8810000
CHEMICAL NAME
: Propane, 1,2-dibromo-2-methylCAS REGISTRY NUMBER
: 594-34-3
BEILSTEIN REFERENCE NO. : 1731237
REFERENCE
: 4-01-00-00298 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C4-H8-Br2
MOLECULAR WEIGHT
: 215.94
WISWESSER LINE NOTATION : E1XE1&1
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 1,2-Dibromo-2-methylpropane
* Isobutylene bromide
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 umol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
34,2576,1974
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mg/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
34,2576,1974
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBROMOPENTANE (1,5-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
:
:
:
:
:
:
SA0320000
Pentane, 1,5-dibromo111-24-0
1209245
4-01-00-00314 (Beilstein Handbook Reference)
199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C5-H10-Br2
MOLECULAR WEIGHT
: 229.97
WISWESSER LINE NOTATION : E5E
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 1,5-Dibromopentane
* Pentamethylene bromide
* Pentamethylene dibromide
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
141,11,1984
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mg/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
34,2576,1974
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIBROMOPHENOL (2,4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* 2,4-Dibromophenol
:
:
:
:
:
:
:
:
:
:
SK8010000
Phenol, 2,4-dibromo615-58-7
1861291
4-06-00-01061 (Beilstein Handbook Reference)
199710
8
C6-H4-Br2-O
251.92
QR BE DE
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0528338
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 282 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(12),19,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(12),19,1979
(V/O
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0530107
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2617
No. of Facilities: 53 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 727 (estimated)
No. of Female Employees: 549 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIBROMOPROPANE (1,2-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* 1,2-Dibromopropane
* 2,3-Dibromopropane
* Propylene dibromide
TX8574000
Propane, 1,2-dibromo78-75-1
1718884
4-01-00-00215 (Beilstein Handbook Reference)
199709
11
C3-H6-Br2
201.91
EY1&1E
Mutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 741 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(3),105,1976
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12 gm/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
(V/O
Projects,
GKNT, 1982
Volume(issue)/page/year: -,43,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 676 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(3),105,1976
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 umol/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 2,59,1980
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
:
:
:
:
Sex chromosome loss and nondisjunction
Oral
Insect - Drosophila melanogaster
5 mmol/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 30,621,1974
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 75716 ug/kg
REFERENCE :
CRTOEC Chemical Research in Toxicology. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57/36, West End Station, Washington,
DC
20037) V.11988- Volume(issue)/page/year: 4,528,1991
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6607
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1822 (estimated)
No. of Female Employees: 272 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBROMOPROPANE (1,3-)
RTECS NUMBER
: TX8575000
CHEMICAL NAME
: Propane, 1,3-dibromoCAS REGISTRY NUMBER
: 109-64-8
LAST UPDATED
: 199710
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C3-H6-Br2
MOLECULAR WEIGHT
: 201.91
WISWESSER LINE NOTATION : E3E
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* alpha,gamma-Dibromopropane
* omega,omega'-Dibromopropane
* 1,3-Dibromopropane
* Trimethylene bromide
* Trimethylene dibromide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 473 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPCEAO Journal fuer Praktische Chemie. (Johann Ambrosius Barth Verlag,
Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.11834Volume(issue)/page/year: 320,133,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Rectal
Rodent - rabbit
1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - irritability
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 34,223,1928
V.1-
1909/10-
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 umol/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 2,59,1980
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIBUTYL PHTHALATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
TI0875000
Phthalic acid, dibutyl ester
84-74-2
1914064
4-09-00-03175 (Beilstein Handbook Reference)
199907
78
C16-H22-O4
278.38
4OVR BVO2
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* o-Benzenedicarboxylic acid, dibutyl ester
* Benzene-o-dicarboxylic acid di-n-butyl ester
* n-Butylphthalate
* Di-n-butylester kyseliny ftalove
* Celluflex DPB
* Dibutyl 1,2-benzenedicarboxylate
* Dibutyl phthalate
* Di-n-butyl phthalate
* Dibutyl phthalate
*
*
*
*
*
*
*
*
*
*
Elaol
Hatcol DBP
Hexaplas M/B
Kodaflex DBP
Palatinol C
Polycizer DBP
PX 104
RCRA waste number U069
Staflex DBP
Witcizer 300
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 140 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - other changes
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co.,
Steintorst 13, 4010 Basel, Switzerland) V.501920Volume(issue)/page/year: 84,1243,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C101,1991
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4250 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 17(8),26,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,44,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3050 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 61,51,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed.,
New
York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year:
2,1904,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9410 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 55(6),86,1990
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5289 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 17(11),51,1973
TYPE OF TEST
ROUTE OF EXPOSURE
: LC50 - Lethal concentration, 50 percent kill
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,44,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.11947Volume(issue)/page/year: 28,667,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KEKHB8 Kanagawa-ken Eisei Kenkyusho Kenkyu Hokoku. Bulletin of Kanagawa
Prefectural Public Health Laboratories. (Kanagawa-ken Eisei Kenkyusho,
52-2, Nakao-cho, Asahi-ku, Yokohama 241, Japan) No.11971Volume(issue)/page/year: (3),19,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8140 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 55(6),86,1990
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/29/1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - withdrawal
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 24(3),25,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(4),86,1974
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 96750 mg/kg/45D-I
TOXIC EFFECTS :
Endocrine - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(6),102,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,609,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
4 gm/kg/4D-I
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,609,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27300 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - normocytic anemia
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3353
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 22750 mg/kg/1Y-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
26,253,1973
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 900 mg/m3/6H/35D-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 17(8),26,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 54600 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-95-3353
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2250 mg/kg
SEX/DURATION
: female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 86,163,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2520 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
26,253,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 8820 mg/kg
SEX/DURATION
: female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
69,197,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
19 gm/kg
female 3-22 day(s) after conception
lactating female 3-20 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Effects on Newborn - physical
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
TOSCF2 Toxicological Sciences. (Academic Press, 6277 Sea Harbor Dr.,
Orlando, FL 32887) V.41-
1998-
Volume(issue)/page/year: 43,47,1998
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1500 mg/kg
SEX/DURATION
: female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 17,223,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1017 mg/kg
SEX/DURATION
: female 5-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 61,51,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 305 mg/kg
SEX/DURATION
: female 5-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 61,51,1972
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
6 gm/kg
female 3-9 day(s) after conception
on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 3,91,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 7200 mg/kg
SEX/DURATION
: female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
OEKSDJ Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Shokuhin Eisei
Hen. Research Reports of the Osaka Prefectural Institute of Public
Health,
Food Sanitation Section. (Osaka-furitsu Koshu Eisei Kenkyusho, 1-3-69
Nakamichi, Higashinari-ku, Osaka 537, Japan) No.11970Volume(issue)/page/year: 8,29,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 8640 mg/kg
SEX/DURATION
: female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 45,65,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 20 gm/kg
SEX/DURATION
: female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
7,29,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 16800 mg/kg
SEX/DURATION
: male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - other effects on male
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
5,413,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 14 gm/kg
SEX/DURATION
: male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
11,141,1982
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 16,61,1985
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 30 mg/L/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
48,337,1977
*** REVIEWS ***
ACGIH TLV-TWA 5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
54,1,1975
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 4,3,1973
TOXICOLOGY REVIEW
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle
Belge
des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.11963Volume(issue)/page/year: 10(3),49,1973
TOXICOLOGY REVIEW
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(93),1,1975
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 4(3),267,1985
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 13,747,1989
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,75,1971
OSHA PEL (Gen Indu):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 5 mg/m3, JAN1999
OEL-BELGIUM:TWA 5 mg/m3 JAN 1993
OEL-HUNGARY:TWA 2 mg/m3;STEL 4 mg/m3;Skin JAN 1993
OEL-JAPAN: OEL 5 mg/m3, JAN1999
OEL-INDIA:TWA 5 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 5 mg/m3, MAC(STEL) 10 mg/m3, JAN1999
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
OEL-SWEDEN:TWA 3 mg/m3;STEL 5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIBUTYL PHTHALATE-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80248
No. of Facilities: 28100 (estimated)
No. of Industries: 192
No. of Occupations: 114
No. of Employees: 258823 (estimated)
NOES - National Occupational
NOES Hazard Code - 80248
No. of Facilities: 31502
No. of Industries: 199
No. of Occupations: 138
No. of Employees: 512631
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
198249 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Dibutyl phthalate, 5020
NTP Toxicity studies, RPT# TOX-30, May 1999
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
DIBUTYLAMINE (N-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
HR7780000
Dibutylamine
111-92-2
0506001
4-11-00-00122 (Beilstein Handbook Reference)
199806
19
C8-H19-N
129.28
4M4
Drug
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1-Butanamine, N-butyl* N-Butyl-1-butanamine
* Dibutilamina
* n-Dibutylamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Moderate
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/25/1970
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 189 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCBUAU Revista de Chimie (Bucharest). (Rompresfilatelia, POB 12-201,
Bucharest, Romania) V.11950- Volume(issue)/page/year: 36,667,1985
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS0515594
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 494 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS0515594
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 40(11),21,1975
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3816470
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1010 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,61,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 40(11),21,1975
(V/O
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
42,19,1977
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 200 mg/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
48,337,1977
*** REVIEWS ***
TOXICOLOGY REVIEW
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office
Dept.
223, POB 57136, West End Stn., Washington, DC 20037) V.11924Volume(issue)/page/year: 9,389,1931
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84285
No. of Facilities: 200 (estimated)
No. of Industries: 8
No. of Occupations: 6
No. of Employees: 977 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84285
No. of Facilities: 711 (estimated)
No. of Industries: 12
No. of Occupations: 17
No. of Employees: 15196 (estimated)
No. of Female Employees: 3349 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro
cytogenetics-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIBUTYLAMINE (SEC-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
:
:
:
:
TX1750000
1-Propanamine, 2-methyl-N-(2-methylpropyl)110-96-3
1209251
REFERENCE
: 4-11-00-00122 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C8-H19-N
MOLECULAR WEIGHT
: 129.28
WISWESSER LINE NOTATION : 1Y1&1M1Y1&1
SYNONYMS/TRADE NAMES :
* 2-Methyl-N-(2-methylpropyl)-1-propanamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 258 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
34(7-9),426,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 629 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
34(7-9),426,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
34(7-9),426,1969
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBUTYLHYDROQUINONE (TERT,2,5-)
RTECS NUMBER
: MX5160000
CHEMICAL NAME
: Hydroquinone, 2,5-di-tert-butylCAS REGISTRY NUMBER
: 88-58-4
BEILSTEIN REFERENCE NO. : 2049542
REFERENCE
: 4-06-00-06074 (Beilstein Handbook Reference)
LAST UPDATED
: 199707
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C14-H22-O2
MOLECULAR WEIGHT
: 222.36
WISWESSER LINE NOTATION : L6V DVJ BX1&1&1 EX1&1&1
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Antage DBH
* 1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)* DBH
* Dibug
* 2,5-Di-tert-butylbenzene-1,4-diol
* 2,5-Di-t-butylhydroquinone
* DTBHQ
* Naugard 451
* Nocrac NS 7
* Santovar O
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: 21MAY1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6426 mg/kg/3W-C
TOXIC EFFECTS :
Blood - change in clotting factors
Related to Chronic Data - death
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.1-
1928-
Volume(issue)/page/year: 109,453,1979
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 134 gm/kg/24W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 12,1341,1991
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7949
No. of Facilities: 155 (estimated)
No. of Industries: 8
No. of Occupations: 14
No. of Employees: 14136 (estimated)
No. of Female Employees: 6832 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIBUTYLTIN DICHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
WH7100000
Stannane, dibutyldichloro683-18-1
199907
54
C8-H18-Cl2-Sn
303.85
G-SN-G4&4
Organometallic
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Chlorid di-n-butylcinicity
* D.B.T.C.
* Dibutyldichlorostannane
* Dibutyldichlorotin
* Dibutylstannium dichloride
* Dibutyltin chloride
* Dibutyltin dichloride
*
*
*
*
*
Di-n-butyltin dichloride
Di-n-butyl-zinn-dichlorid
Dichlorodibutylstannane
Dichlorodibutyltin
Tin, dibutyl-, dichloride
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1248,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1248,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 10,44,1960
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >364 mg/m3/4H
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555188
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Intraperitoneal
: Rodent - rat
DOSE/DURATION
: 7500 ug/kg
TOXIC EFFECTS :
Vascular - shock
REFERENCE :
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9,
1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year:
2,183,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - chronic pulmonary edema
Liver - liver function tests impaired
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
15,15,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 126 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TIUSAD Tin and Its Uses. (Tin Research Institute, 483 W. 6th Ave.,
Columbus, OH 43201) No.11939- Volume(issue)/page/year: 107,1,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
39,572,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00182
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1248,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 15,3,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
15,15,1958
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
15,15,1958
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 162 mg/kg/8W-C
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
15,15,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 378 mg/kg/6W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in cellular immune response
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,213,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 20 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - other changes
Endocrine - changes in thymus weight
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
AGSOA6 Agressologie. Revue Internationale de Physio-Biologie et de
Pharmacologie Appliquees aux Effets de l'Agression. (SPPIF, B.P.22,
F-41353
Vineuil, France) V.11960- Volume(issue)/page/year: 27,123,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 70 mg/kg/4W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
42,213,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg/5D-I
TOXIC EFFECTS :
Liver - other changes
Related to Chronic Data - death
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
15,15,1958
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 45 mg/kg
SEX/DURATION
: female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
58,347,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 20 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 73,81,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 150 mg/kg
SEX/DURATION
: female 13-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 16,71,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 20 mg/kg
SEX/DURATION
: female 7-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 15,297,1995
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 ug/tube
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
300,265,1993
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 ng/tube
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
280,195,1992
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 2 mg/disk
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
280,195,1992
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 ug/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
64,482,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rabbit Cells - not otherwise specified
DOSE/DURATION
: 10 ug/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 16,229,1985
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: DNA inhibition
: Rodent - rabbit Cells - not otherwise specified
: 100 ug/L
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 16,229,1985
*** REVIEWS ***
ACGIH TLV-TWA 0.1 mg(Sn)/m3;STEL 0.2 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 4,61,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 mg(Sn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,258,1971
OSHA PEL (Gen Indu):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-AUSTRIA: MAK 0.1 mg(Sn)/m3, Skin, JAN1999
OEL-BELGIUM:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.1 mg(Sn)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.1 mg(Sn)/m3;STEL 0.3 mg(Sn)/m3;Skin JAN 1993
OEL-GERMANY:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-HUNGARY:STEL 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 mg(Sn)/m3 JAN 1993
OEL-SWEDEN:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
OEL-THAILAND:TWA 0.1 mg(Sn)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ORGANOTIN COMPOUND-air:10H TWA 0.1 mg(Sn)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIBUTYLTIN OXIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
LAST UPDATED
:
WH7175000
Stannane, dibutyloxo818-08-6
4126243
199907
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
35
C8-H18-O-Sn
248.95
O-SN-4&4
Organometallic
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* DBOT
* Dibutyloxide of tin
* Dibutyloxostannane
* Dibutyloxotin
* Dibutylstannane oxide
* Dibutylstannium oxide
* Dibutyltin oxide
* Di-n-butyltin oxide
* Di-n-butyl-zinn-oxyd
* Kyslicnik di-n-butylcinicity
* Tin, dibutyloxo* Tin, dibutyl-, oxide
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1248,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555391
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 44900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1248,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 7,47,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 15,3,1973
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Kidney, Ureter, Bladder - other changes
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570737
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 31200 ug/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
Blood - normocytic anemia
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(4),14,1977
** REPRODUCTIVE DATA **
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 19916 ug/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 85,149,1993
*** REVIEWS ***
ACGIH TLV-TWA 0.1 mg(Sn)/m3;STEL 0.2 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 4,61,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 mg(Sn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,258,1971
OSHA PEL (Gen Indu):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
Volume(issue)/page/year:
OSHA PEL (Fed Cont):8H TWA 0.1 mg(Sn)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-AUSTRIA: MAK 0.1 mg(Sn)/m3, Skin, JAN1999
OEL-BELGIUM:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-DENMARK: TWA 0.1 mg(Sn)/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.1 mg(Sn)/m3;STEL 0.3 mg(Sn)/m3;Skin JAN 1993
OEL-GERMANY:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-HUNGARY:STEL 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 mg(Sn)/m3 JAN 1993
OEL-SWEDEN:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
OEL-THAILAND:TWA 0.1 mg(Sn)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ORGANOTIN COMPOUND-air:10H TWA 0.1 mg(Sn)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0245
No. of Facilities: 503 (estimated)
No. of Industries: 8
No. of Occupations: 9
No. of Employees: 4009 (estimated)
No. of Female Employees: 691 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIBUTYRYLADENOSINE (N,6,2',ORTHO-)
RTECS NUMBER
: ES5055500
CHEMICAL NAME
: Butyramide,
N-(9-beta-D-ribofuranosyl-9H-purin-6-yl)-, cyclic
hydrogen phosphate, butyrate (ester), monosodium
salt
CAS REGISTRY NUMBER
: 16980-89-5
LAST UPDATED
: 199612
DATA ITEMS CITED
: 14
MOLECULAR FORMULA
: C18-H23-N5-O8-O.Na
MOLECULAR WEIGHT
: 476.45
COMPOUND DESCRIPTOR
: Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen
phosphate)-2'-butanoate, monosodium salt
* Bucladesine sodium
* Dibutyl cAMP sodium salt
* Dibutyl cyclic AMP sodium
* Dibutyl cyclic AMP sodium salt
* DT 5621 sodium salt
* Monosodium dibutyryl cyclic AMP
* Sodium dibutyryl cAMP
* Sodium dibutyryl 3',5'-cyclic AMP
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 36,357,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Administration onto the skin
: Rodent - rat
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.11972Volume(issue)/page/year: 18,2543,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 515 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 15,1140,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 487 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 15,1140,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 448 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 15,1140,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 36,357,1985
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1024 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 36,357,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 678 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 15,1140,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 543 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 15,1140,1984
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 840 mg/kg
SEX/DURATION
: female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 27,571,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2200 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - sex ratio
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 27,585,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 138 mg/kg
SEX/DURATION
: female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 27,585,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - rat
340 mg/kg
female 17-22 day(s) after conception
lactating female 28 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 27,599,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - rat
630 mg/kg
male 9 week(s) pre-mating
female 2 week(s) pre-mating
female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 27,571,1984
DICHLOROACETIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
:
:
:
:
:
:
:
:
:
AG6125000
Acetic acid, dichloro79-43-6
42428-47-7
1098596
4-02-00-00498 (Beilstein Handbook Reference)
199907
29
C2-H2-Cl2-O2
MOLECULAR WEIGHT
: 128.94
WISWESSER LINE NOTATION : QVYGG
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bichloracetic acid
* DCA (acid)
* Dichloracetic acid
* Dichlorethanoic acid
* Dichloroacetic acid
* 2,2-Dichloroacetic acid
* Dichloroethanoic acid
* Kyselina dichloroctova
* Urner's liquid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,570,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 510 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3195 mg/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 64,71,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7100 mg/kg/10W-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Biochemical - Effect on specific coenzyme - CoA
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 110,103,1996
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 114,207,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 427 gm/kg/61W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
90,183,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 101 gm/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
92,67,1995
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 9 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 46,217,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 24 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - sex ratio
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 46,217,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 46,217,1992
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
14 gm/kg
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 46,217,1992
** MUTATION DATA **
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1800 mg/kg/9D (Continuous)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
27,1,1996
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 645 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
20,277,1992
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
413,265,1998
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 400 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
413,265,1998
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 63,271,1995
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 63,271,1995
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 63,271,1995
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 4 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84531
No. of Facilities: 44 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 164 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84531
No. of Facilities: 39 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1592 (estimated)
No. of Female Employees: 579 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; selected, May 1999
NTP Carcinogenesis studies; laboratory assigned, May 1999
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
DICHLOROANILINE (2,3-)
RTECS NUMBER
: CX9862625
CHEMICAL NAME
: Benzenamine, 2,3-dichloroCAS REGISTRY NUMBER
: 608-27-5
LAST UPDATED
: 199710
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C6-H5-Cl2-N
MOLECULAR WEIGHT
: 162.02
SYNONYMS/TRADE NAMES :
* Aniline, 2,3-dichloro* 2,3-Dichloroaniline
* 2,3-Dichlorobenzenamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >8047 mg/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537682
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROANILINE (2,4-)
RTECS NUMBER
: BX2600000
CHEMICAL NAME
: Aniline, 2,4-dichloroCAS REGISTRY NUMBER
: 554-00-7
BEILSTEIN REFERENCE NO. : 0386422
REFERENCE
: 4-12-00-01241 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C6-H5-Cl2-N
MOLECULAR WEIGHT
: 162.02
WISWESSER LINE NOTATION : ZR BG DG
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzenamine, 2,4-dichloro* o,p-Dichloroaniline
* 2,4-Dichloranilin
* 2,4-Dichloroaniline
* 2,4-Dichlorobenzenamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cyanosis
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cyanosis
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cyanosis
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - cyanosis
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 113 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Lungs, Thorax, or Respiration - cyanosis
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 72,241,1913
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROANILINE (2,5-)
RTECS NUMBER
: BX2610000
CHEMICAL NAME
: Aniline, 2,5-dichloroCAS REGISTRY NUMBER
: 95-82-9
BEILSTEIN REFERENCE NO. : 1447438
REFERENCE
: 4-12-00-01250 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 13
MOLECULAR FORMULA
: C6-H5-Cl2-N
MOLECULAR WEIGHT
: 162.02
WISWESSER LINE NOTATION : ZR BG EG
SYNONYMS/TRADE NAMES :
* Amarthol Fast Scarlet GG Base
* Amarthol Fast Scarlet GGS Base
* Azobase DCA
* Azoene Fast Scarlet 2G Base
* Azogene Fast Scarlet GGC
* Azogene Fast Scarlet GG (free base)
* Azoic Diazo Component 3
* Benzenamine, 2,5-dichloro-
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
C.I. 37010
C.I. Azoic Diazo Component 3
Daito Scarlet Base GG
Devol Scarlet A (free base)
Devol Scarlet 2GS Base
Diazo Fast Scarlet GG
2,5-Dichloranilin
2,5-Dichloroaniline
2,5-Dichlorobenzenamine
Fast Red SGG Base
Fast Scarlet Base ggt
Fast Scarlet Base 2J
Fast Scarlet Base 2JS
Fast Scarlet DS Base
Fast Scarlet 2G
Fast Scarlet 2G Base
Fast Scarlet GG Base
Fast Scarlet GGS Base
Fast Scarlet MDC Base
Hiltonil Fast Scarlet 2G Base
Hiltonil Fast Scarlet 2GS Base
Hindamine Scarlet GG
Kambamine Scarlet GG base
Kayaku Scarlet GG Base
Lake Scarlet GG Base
Mitsui Scarlet GG base
Naphthanil Scarlet 2G Base
Naphtoelan Fast Scarlet GG Base
Sanyo Fast Scarlet GG Base
Scarlet Base Ciba I
Scarlet Base GG
Scarlet Base IRGA I (free base)
Scarlet Base NGG
Scarlet 2G Base
Spectrolene Scarlet 2G
Stabamine Scarlet GG
Symulon Scarlet 2G Base
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - rat
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 206512
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00202
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3750 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(4),8,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3750 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(4),8,1968
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27300 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(4),8,1968
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4027
No. of Facilities: 116 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 2820 (estimated)
No. of Female Employees: 246 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROBENZENE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
CZ4500000
Benzene, o-dichloro95-50-1
199907
70
C6-H4-Cl2
147.00
GR BG
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzene, 1,2-dichloro* Chloroben
* o-Dichlorbenzene
* o-Dichlor benzol
* o-Dichlorobenzene
* 1,2-Dichlorobenzene
* o-Dichlorobenzene
* Dilatin DB
* Dizene
* Dowtherm E
* NCI-C54944
* Orthodichlorobenzene
* Orthodichlorobenzol
* Special termite fluid
* Termitkil
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Rinsed with water
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/30S
REACTION SEVERITY
: Mild
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
17,180,1958
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 9,119,1970
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 821 ppm/7H
TOXIC EFFECTS :
Behavioral - general anesthetic
Liver - hepatitis (hepatocellular necrosis), zonal
Sense Organs and Special Senses (Eye) - lacrimation
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
17,180,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 840 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 20,519,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS 205976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4386 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 32,471,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1228 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96,
1892-1968. For publisher information, see JPTLAS.
Volume(issue)/page/year:
44,281,1937
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA,
Thomson
Publications, 1976/77 revision Volume(issue)/page/year: 3,32,1976/1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0521597
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96,
1892-1968. For publisher information, see JPTLAS.
Volume(issue)/page/year:
44,281,1937
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed.,
New
York, John Wiley & Sons, Inc., 1958-63
2,1336,1963
Volume(issue)/page/year:
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 800 ppm/24H
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
REFERENCE :
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96,
1892-1968. For publisher information, see JPTLAS.
Volume(issue)/page/year:
44,281,1937
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27300 ug/kg/39W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - agranulocytosis
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(10),15,1968
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 gm/kg/10D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Blood - changes in leukocyte (WBC) count
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 14,83,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 32500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Blood - changes in erythrocyte (RBC) count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-255,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
(Research
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7 gm/kg/14D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-255,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-255,1985
(Research
(Research
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 ppm/6H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,190,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 4(1),224,1985
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
: Gene conversion and mitotic recombination
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
413,205,1998
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 4(2),224,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 187 mg/kg/24H
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 6500 ug/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 59 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 301 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 150 mg/m3 (25 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 7,231,1974
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 7,231,1974
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,213,1982
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,213,1982
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,192,1987
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD:air-CL 50 ppm (300 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,76,1971
OSHA PEL (Gen Indu):CL 50 ppm (300 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):CL 50 ppm (300 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 50 ppm (300 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 50 ppm (300 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 50 ppm (300 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 50 ppm (300 mg/m3), Skin, JAN1999
OEL-AUSTRIA:TWA 50 ppm (300 mg/m3) JAN 1993
OEL-BELGIUM:STEL 50 ppm (301 mg/m3);Skin JAN 1993
OEL-FINLAND:TWA 50 ppm (300 mg/m3);STEL 75 ppm (450 mg/m3);Skin JAN 1993
OEL-JAPAN: STEL 25 ppm (150 mg/m3), JAN1999
OEL-GERMANY:TWA 50 ppm (300 mg/m3);Skin JAN 1993
OEL-HUNGARY:TWA 50 mg/m3;STEL 100 mg/m3;Skin JAN 1993
OEL-JAPAN:STEL 50 ppm (300 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 20 mg/m3, MAC(CEILING) 300 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 50 ppm (300 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 50 ppm (300 mg/m3) JAN 1993
OEL-RUSSIA:STEL 50 mg/m3 JAN 1993
OEL-SWEDEN:STEL 50 ppm (300 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 50 ppm (300 mg/m3);STEL 100 ppm (600 mg/m3) JAN 1993
OEL-THAILAND:TWA 50 ppm (300 mg/m3) JAN 1993
OEL-TURKEY:TWA 50 ppm (300 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 50 ppm (300 mg/m3);STEL 50 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO o-DICHLOROBENZENE-air:CL 50 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24003
No. of Facilities: 8838 (estimated)
No. of Industries: 83
No. of Occupations: 69
No. of Employees: 72149 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24003
No. of Facilities: 10577 (estimated)
No. of Industries: 59
No. of Occupations: 59
No. of Employees: 92246 (estimated)
No. of Female Employees: 12686 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-255,1985
(Research
DICHLOROBENZENE (1,3-)
RTECS NUMBER
: CZ4499000
CHEMICAL NAME
: Benzene, m-dichloroCAS REGISTRY NUMBER
: 541-73-1
LAST UPDATED
: 199710
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C6-H4-Cl2
MOLECULAR WEIGHT
: 147.00
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzene, 1,3-dichloro* m-Dichlorobenzene
* 1,3-Dichlorobenzene
* m-Dichlorobenzol
* m-Phenylenedichloride
* RCRA waste number U071
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1062 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1470 mg/kg/10D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - changes in calcium
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 18,201,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3330 mg/kg/90D-I
TOXIC EFFECTS :
Endocrine - other changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 18,201,1995
** MUTATION DATA **
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 5 ppm
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-138973
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 175 mg/kg/24H
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2135
No. of Facilities: 49 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 418 (estimated)
No. of Female Employees: 80 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROBENZENE (1,4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
:
:
:
:
:
:
CZ4550000
Benzene, p-dichloro106-46-7
199907
86
C6-H4-Cl2
MOLECULAR WEIGHT
: 147.00
WISWESSER LINE NOTATION : GR DG
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* p-Chlorophenyl chloride
* p-Dichloorbenzeen
* 1,4-Dichloorbenzeen
* p-Dichlorbenzol
* 1,4-Dichlor-benzol
* Di-chloricide
* p-Dichlorobenzene
* 1,4-Dichlorobenzene
* p-Dichlorobenzene
* p-Dichlorobenzol
* p-Diclorobenzene
* 1,4-Diclorobenzene
* Evola
* Globol
* NCI-C54955
* Paracide
* Para crystals
* Paradi
* Paradichlorbenzol
* Paradichlorobenzene
* Paradichlorobenzol
* Paradow
* Paramoth
* Paranuggets
* Parazene
* PDB
* PDCB
* Persia-perazol
* RCRA waste number U070
* RCRA waste number U071
* RCRA waste number U072
* Santochlor
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Human
DOSE/DURATION
: 80 ppm
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,138,1956
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,851,1966
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 857 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,210,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human
DOSE/DURATION
: 357 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,1499,1980
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 221 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 9,119,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 7,299,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2562 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 38,124,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information
Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year:
6,183,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5145 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho
University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.11954- Volume(issue)/page/year: 20,772,1973
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 37 gm/m3/30M
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 38,1045,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 29,453,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,18,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,138,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 12 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-319,1987
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 58500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Blood - changes in erythrocyte (RBC) count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-319,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/kg/4W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,138,1956
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 158 ppm/7H/31W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,138,1956
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 gm/m3/20M/25D-I
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - tremor
Blood - granulocytopenia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 38,124,1949
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 58500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in leukocyte (WBC) count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-319,1987
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3 gm/kg/1W-I
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 39,67,1997
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 92 gm/kg/31W-I
TOXIC EFFECTS :
Behavioral - tremor
Related to Chronic Data - death
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,138,1956
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 gm/m3/30M/31D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Blood - granulocytopenia
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 38,124,1949
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 158 ppm/7H/31W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,138,1956
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 100 gm/m3/20M/20D-I
TOXIC EFFECTS :
Blood - granulocytopenia
Related to Chronic Data - death
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 38,124,1949
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
155 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-319,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 155 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-319,1987
(Research
(Research
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 37,164,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 37,164,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 800 ppm/6H
SEX/DURATION
: female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,190,1985
** MUTATION DATA **
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
413,205,1998
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 200 mg/L
REFERENCE :
CJMIAZ Canadian Journal of Microbiology. (National Research Council of
Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada)
V.11954- Volume(issue)/page/year: 16,369,1970
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
263,57,1991
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
REFERENCE :
ACDSEL Advances in Contraceptive Delivery Systems. (Reproductive Health
Center, 78 Surfsong Rd., Kiawah Island, SC 29455) V.11985Volume(issue)/page/year: 2,248,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 355 mg/kg/24H
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1391,201,1997
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 60 mg/m3 (10 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,192,1987
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 7,231,1974
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 7,231,1974
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,213,1982
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.1-
1972-
Volume(issue)/page/year: 29,213,1982
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,192,1987
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
1(1),93,1971
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 75 ppm (450 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,77,1971
OSHA PEL (Gen Indu):8H TWA 75 ppm (450 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 75 ppm (450 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 75 ppm (450 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 75 ppm (450 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 75 ppm (450 mg/m3);STEL 110 ppm (675 mg/m3) JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-BELGIUM:TWA 75 ppm (451 mg/m3);STEL 110 ppm (661 mg/m3) JAN 1993
OEL-FINLAND:TWA 75 ppm (450 mg/m3);STEL 115 ppm (690 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 75 ppm (450 mg/m3) JAN 1993
OEL-JAPAN: OEL 50 ppm (300 mg/m3), 2B Carcinogen, JAN1999
OEL-JAPAN:TWA 50 ppm (300 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 75 ppm (450 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 75 ppm (450 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 20 mg/m3, JAN1999
OEL-RUSSIA:TWA 50 ppm JAN 1993
OEL-SWEDEN:TWA 75 ppm (450 mg/m3);STEL 110 ppm (700 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 75 ppm (450 mg/m3);STEL 150 ppm (900 mg/m3) JAN 1993
OEL-TURKEY:TWA 75 ppm (450 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 75 ppm (450 mg/m3);STEL 110 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO p-DICHLOROBENZENE-air:CA (1.7 ppm LOQ)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24006
No. of Facilities: 1963 (estimated)
No. of Industries: 21
No. of Occupations: 18
No. of Employees: 23116 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24006
No. of Facilities: 2629 (estimated)
No. of Industries: 22
No. of Occupations: 21
No. of Employees: 33978 (estimated)
No. of Female Employees: 9412 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/89/160352/AS
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9004
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-319,1987
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
DICHLOROBENZIDINE DIHYDROCHLORIDE (3,3'-)
RTECS NUMBER
: DD0525000
CHEMICAL NAME
: Benzidine, 3,3'-dichloroCAS REGISTRY NUMBER
: 91-94-1
BEILSTEIN REFERENCE NO. : 2108022
REFERENCE
: 4-13-00-00384 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 53
MOLECULAR FORMULA
: C12-H10-Cl2-N2
MOLECULAR WEIGHT
: 253.14
WISWESSER LINE NOTATION : ZR BG DR DZ CG
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* (1,1'-Biphenyl)-4,4'-diamine, 3,3'-dichloro* C.I. 23060
* Curithane C126
*
*
*
*
*
*
*
*
*
*
*
*
*
*
4,4'-Diamino-3,3'-dichlorobiphenyl
4,4'-Diamino-3,3'-dichlorodiphenyl
3,3'-Dichlorbenzidin
3,3'-Dichlorobenzidina
Dichlorobenzidine
o,o'-Dichlorobenzidine
3,3'-Dichlorobenzidine
Dichlorobenzidine base
3,3'-Dichlorobenzidine
3,3'-Dichloro-4,4'-biphenyldiamine
3,3'-Dichlorobiphenyl-4,4'-diamine
3,3'-Dichloro-4,4'-diaminobiphenyl
3,3'-Dichloro-4,4'-diamino(1,1-biphenyl)
RCRA waste number U073
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 17 gm/kg/50W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
Skin and Appendages - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
31,159,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3600 mg/kg/61W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - breast
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 21(6),110,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5100 mg/kg/43W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 5(5),524,1959
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
320 mg/kg
female 15-21 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Lungs, Thorax, or Respiration - tumors
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 78,1402,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5200 mg/kg/47W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Tumorigenic - tumors at site of application
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 5(5),524,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 17 gm/kg/7Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - tumors
REFERENCE :
DUPON* E.I. Dupont de Nemours and Company, Technical Sheet. (1007 Market
St., Wilmington, DE 19898) Volume(issue)/page/year: HL623-74,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 176 gm/kg/70W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 10,78,1969
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 5(5),524,1959
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 21 gm/kg/50W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
Skin and Appendages - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
31,159,1975
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7 gm/kg/43W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 5(5),524,1959
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ug/plate
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
4,21,1977
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 nmol/plate
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,225,1987
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 100 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,2621,1978
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 5 mg/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
51,799,1973
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION
: 40 mg/kg
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 23,426,1981
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,267,1987
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
319,19,1993
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
319,19,1993
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 12500 ug/L
REFERENCE :
AETODY Advances in Modern Environmental Toxicology.
P.O. Box 252, Princeton Junction, NJ 08550) V.1Volume(issue)/page/year: 1,241,1980
(Senate Press, Inc.,
1980-
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
37,873,1978
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 25500 nmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
38,369,1982
*** REVIEWS ***
ACGIH TLV-Animal carcinogen, NO TWA (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 4,49,1974
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,239,1982
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,239,1982
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979-
Volume(issue)/page/year:
7,193,1987
TOXICOLOGY REVIEW
ADCSAJ Advances in Chemistry Series. (American Chemical Soc.,
Distribution
Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037)
1950- Volume(issue)/page/year: 13,271,1970
No.1-
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:skin-HUMAN CARCINOGEN, NO ASSIGNED TWA
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,77,1971
OSHA PEL (Gen Indu):see CFR 29,1910.1007
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):see CFR 29,1926.1107
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):see CFR 29,1915.1007
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA-cancer suspect agent
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1007,1987
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA;Skin;Carcinogen JAN 1993
OEL-AUSTRIA: Skin, Carcinogen, JAN1999
OEL-GERMANY;Skin;Carcinogen JAN 1993
OEL-SWEDEN;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg/m3;Skin;Carcinogen JAN 1993
OEL-SWITZERLAND;Carcinogen JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 3,3'-DICHLOROBENZIDINE-air:CA use 29 CFR 1910.1007
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/171455/AS
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: 3,3'-Dichlorobenzidine, 5509
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
OSHA ANALYTICAL METHOD #ID-65
DICHLOROBENZONITRILE (2,6-)
RTECS NUMBER
: DI3500000
CHEMICAL NAME
: Benzonitrile, 2,6-dichloroCAS REGISTRY NUMBER
: 1194-65-6
BEILSTEIN REFERENCE NO. : 1909167
REFERENCE
: 4-09-00-01006 (Beilstein Handbook Reference)
LAST UPDATED
: 199801
DATA ITEMS CITED
: 17
MOLECULAR FORMULA
: C7-H3-Cl2-N
MOLECULAR WEIGHT
: 172.01
WISWESSER LINE NOTATION : NCR BG FG
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Casoron
* Casoron 133
* Code H 133
* Cyclomec
* 2,6-DBN
* DBN
* Decabane
* Dichlobenil
* 2,6-Dichlorbenzonitril
* 2,6-Dichlorobenzonitrile
* DU-Sprex
* H 133
* H 1313
* NIA 5996
* Niagara 5,996
* Norosac
* Prefix D
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094) V.11962- Volume(issue)/page/year:
10,97,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,
Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,145,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2056 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,73,1976
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >200 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - deviated nasal septum
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.11979- Volume(issue)/page/year: 15,287,1994
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 41,41,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 270 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Liver - other changes
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 6,261,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information
Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year:
6,177,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - guinea pig
681 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,337,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,
Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,144,1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg/5D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - deviated nasal septum
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.11979- Volume(issue)/page/year: 15,287,1994
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 260 ug/kg/39D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de
Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870Volume(issue)/page/year: 122,107,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 260 ug/kg/39D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Tumorigenic - tumors at site of application
REFERENCE :
AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de
Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy)
Volume(issue)/page/year: 122,107,1979
1870-
*** REVIEWS ***
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24030
No. of Facilities: 40 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 200 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROBENZOPHENONE (4,4'-)
RTECS NUMBER
: DJ0525000
CHEMICAL NAME
: Benzophenone, 4,4'-dichloroCAS REGISTRY NUMBER
: 90-98-2
BEILSTEIN REFERENCE NO. : 0643345
REFERENCE
: 4-07-00-01376 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C13-H8-Cl2-O
MOLECULAR WEIGHT
: 251.11
WISWESSER LINE NOTATION : GR DVR DG
SYNONYMS/TRADE NAMES :
* Bis(p-chlorophenyl)ketone
* Bis(4-chlorophenyl)ketone
* DBP (degradation product)
* p,p'-Dichlorobenzophenone
* 4,4'-Dichlorobenzophenone
* Di(p-chlorophenyl)ketone
* Di(4-chlorophenyl)ketone
* Methanone, bis(4-chlorophenyl)-
* USAF DO-4
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DICHLOROBENZOYL CHLORIDE (2,4-)
RTECS NUMBER
: DM6636733
CHEMICAL NAME
: Benzoyl chloride, 2,4-dichloroCAS REGISTRY NUMBER
: 89-75-8
LAST UPDATED
: 199906
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C7-H3-Cl3-O
MOLECULAR WEIGHT
: 209.45
SYNONYMS/TRADE NAMES :
* 2,4-Dichlorobenzoyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4640 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537054
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Administration onto the skin
: Rodent - rabbit
DOSE/DURATION
: 3160 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537054
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROBIPHENYL (4,4'-)
RTECS NUMBER
: DV3912500
CHEMICAL NAME
: 1,1'-Biphenyl, 4,4'-dichloroCAS REGISTRY NUMBER
: 2050-68-2
LAST UPDATED
: 199907
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C12-H8-Cl2
MOLECULAR WEIGHT
: 223.10
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Biphenyl, 4,4'-dichloro* p,p-Dcbp
* p,p'-Dichlorobiphenyl
* 4,4'-Dichlorobiphenyl
* PCB 15
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 mg/kg/3D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other hydrolases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
33,94,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 700 mg/kg/7D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,418,1974
** MUTATION DATA **
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
342,61,1995
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRIA: MAK 0.1 ppm (1 mg/m3), Skin, Suspected Carcinogen, JAN1999
OEL-JAPAN: OEL 0.1 mg/m3, Skin, 2A Carcinogen, JAN1999
*** STATUS IN U.S. ***
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROBUTYNE (1,4-)
RTECS NUMBER
: ER9600000
CHEMICAL NAME
: 2-Butyne, 1,4-dichloroCAS REGISTRY NUMBER
: 821-10-3
BEILSTEIN REFERENCE NO. : 0635740
REFERENCE
: 4-01-00-00973 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C4-H4-Cl2
MOLECULAR WEIGHT
: 122.98
WISWESSER LINE NOTATION : G2UU2G
SYNONYMS/TRADE NAMES :
* 1,4-Dichlorobutyne
* 1,4-Dichloro-2-butyne
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#02969
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DICHLOROCINNAMIC ACID (3,4-)
RTECS NUMBER
: UD3333900
CHEMICAL NAME
: 2-Propenoic acid, 3-(3,4-dichlorophenyl)CAS REGISTRY NUMBER
: 1202-39-7
BEILSTEIN REFERENCE NO. : 1872129
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C9-H6-Cl2-O2
MOLECULAR WEIGHT
: 217.05
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 3-(3,4-Dichlorophenyl)-2-propenoic acid
* 3,4-Dichlorocinnamic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >250 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Behavioral - rigidity (including catalepsy)
REFERENCE :
IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz
(East), Bombay 400 029, India) V.40(2)1978Volume(issue)/page/year:
49,77,1987
DICHLORODICYANO BENZOQUINONE
RTECS NUMBER
: GU4825000
CHEMICAL NAME
: 1,4-Cyclohexadiene-1,2-dicarbonitrile,
4,5-dichloro-3,6-dioxoCAS REGISTRY NUMBER
: 84-58-2
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C8-Cl2-N2-O2
MOLECULAR WEIGHT
: 227.00
WISWESSER LINE NOTATION : L6V DVJ BCN CCN EG FG
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* DDQ
* Dichlorodicyanobenzoquinone
* Dichlorodicyano-p-benzoquinone
* 2,3-Dichloro-5,6-dicyanobenzoquinone
* Dichlorodicyanoquinone
* 4,5-Dichloro-3,6-dioxo-1,4-cyclohexadiene-1,2-dicarbonitrile
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 31 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New
York, NY 10003) V.131968- Volume(issue)/page/year: 16,371,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#07894
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 180 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
347,37,1995
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DICHLORODIFLUOROMETHANE
RTECS NUMBER
: PA8200000
CHEMICAL NAME
: Methane, dichlorodifluoroCAS REGISTRY NUMBER
: 75-71-8
LAST UPDATED
: 199907
DATA ITEMS CITED
: 50
MOLECULAR FORMULA
: C-Cl2-F2
MOLECULAR WEIGHT
: 120.91
WISWESSER LINE NOTATION : GXGFF
COMPOUND DESCRIPTOR
: Human
SYNONYMS/TRADE NAMES :
* Algofrene type 2
* Arcton 6
* Arcton 12
* CFC 12
* Chlorofluorocarbon 12
* Dichlorodifluoromethane
* Difluorodichloromethane
* Dwuchlorodwufluorometan
* Dymel 12
* Electro-CF 12
* F 12
* FC 12
* FCC 12
* FKW 12
* Fluorocarbon-12
* Forane 12
* Freon 12
* Eskimon 12
* Freon F-12
* Frigen 12
* Genetron 12
* Isceon 122
* Isotron 12
* Kaiser chemicals 12
* Ledon 12
* Propellant 12
* RCRA waste number U075
* R 12 (refrigerant)
* Refrigerant R 12
* Ucon 12
* Ucon 12/halocarbon 12
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 200000 ppm/30M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - fibrosing alveolitis
Liver - other changes
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,385,1976
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(3),73,1987
(Paris,
(V/O
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >80 pph/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520424
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3348 gm/m3/3H
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - tremor
Behavioral - excitement
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 28(6),95,1963
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 80 pph/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,385,1976
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 80 pph/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,385,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2548 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(3),73,1987
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4136 mg/m3/8H/6W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3997 mg/m3/90D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 3997 mg/m3/90D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3997 mg/m3/90D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3997 mg/m3/90D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Liver - hepatitis (hepatocellular necrosis), diffuse
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,270,1967
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 4950 mg/m3 (1000 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug
Research.
(Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
Secaucus, NJ 07094) V.11959- Volume(issue)/page/year: 18,365,1974
TOXICOLOGY REVIEW
NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of
New York, POB 5405, Lake Success, NY 11042) V.11901Volume(issue)/page/year: 74,1939,1974
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 1000 ppm (4950 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,78,1971
OSHA PEL (Gen Indu):8H TWA 1000 ppm (4950 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1000 ppm (4950 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1000 ppm (4950 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1000 ppm (4950 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1000 ppm (4950 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 1000 ppm (5000 mg/m3), JAN1999
OEL-AUSTRIA:TWA 1000 ppm (5000 mg/m3) JAN 1993
OEL-BELGIUM:TWA 1000 ppm (4950 mg/m3) JAN 1993
OEL-FINLAND:TWA 1000 ppm (4950 mg/m3);STEL 1250 ppm (6200 mg/m3) JAN 1993
OEL-JAPAN: OEL 500 ppm (2500 mg/m3), JAN1999
OEL-GERMANY:TWA 1000 ppm (5000 mg/m3) JAN 1993
OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993
OEL-JAPAN:TWA 500 ppm (2500 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 4000 mg/m3, MAC(STEL) 6200 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 1000 ppm (4950 mg/m3) JAN 1993
OEL-SWEDEN: NGV 500 ppm (2500 mg/m3), KTV 750 ppm (4000 mg/m3), JAN1999
OEL-THE PHILIPPINES:TWA 1000 ppm (4950 mg/m3) JAN 1993
OEL-RUSSIA:TWA 500 ppm;STEL 3000 mg/m3 JAN 1993
OEL-SWEDEN:TWA 500 ppm (2500 mg/m3);STEL 750 ppm (4000 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 1000 ppm (5000 mg/m3) JAN 1993
OEL-TURKEY:TWA 1000 ppm (4950 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1000 ppm (4950 mg/m3);STEL 1250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DICHLORODIFLUOROMETHANE-air:10H TWA 1000 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24095
No. of Facilities: 139220 (estimated)
No. of Industries: 403
No. of Occupations: 213
No. of Employees: 1892483 (estimated)
NOES - National Occupational
NOES Hazard Code - 24095
No. of Facilities: 30739
No. of Industries: 177
No. of Occupations: 140
No. of Employees: 510790
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
143439 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Dichlorodifluoromethane, 1018
DICHLORODIMETHYL HYDANTOIN
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
OTHER CAS REGISTRY NOS. :
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
(1,3:5,5-)
MU0700000
Hydantoin, 1,3-dichloro-5,5-dimethyl118-52-5
55945-60-3
0146013
5-24-05-00373 (Beilstein Handbook Reference)
199712
35
C5-H6-Cl2-N2-O2
197.03
T5NVNV EHJ AG CG E1 E1
Agricultural Chemical
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Dactin
* Daktin
* Dantoin
* Dichlorantin
* 1,3-Dichloro-5,5-dimethylhydantoin
* 1,3-Dichloro-5,5-dimethyl hydantoin
* 1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione
* 1,3-Dichloro-5,5'-methylhydantoin
* Dwuchlorantyny
* 1,3-Dwuchloro-5,5-dwumetylohydantoina
* Halane
* Hydan
* Hydan (antiseptic)
* Hydantoin, dichlorodimethyl* 2,4-Imidazolidinedione, 1,3-dichloro-5,5-dimethyl* NCI-C03054
* Omchlor
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0281-0382
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0281-0382
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 542 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,183,1986
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 gm/m3/1H
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0281-0382
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 19,52,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rabbit
1520 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - withdrawal
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 47(6),76,1982
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0281-0382
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1350 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - withdrawal
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 47(6),76,1982
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and
Trademark Office, Foreign Patents, Washington, DC 20231)
Volume(issue)/page/year: #2550828
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8784 mg/kg/28D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.4-
1971-
Volume(issue)/page/year: 19,52,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 634 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 47(6),76,1982
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 250 ppm
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,677,1985
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 6300 ng/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,190,1981
*** REVIEWS ***
ACGIH TLV-STEL 0.4 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.2 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.2 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,78,1971
OSHA PEL (Gen Indu):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.2 mg/m3;STEL 0.4 mg/m3 JAN 1993
OEL-BELGIUM:TWA 0.2 mg/m3;STEL 0.4 mg/m3 JAN 1993
OEL-FINLAND:TWA 0.2 mg/m3;STEL 0.6 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.2 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.2 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 mg/m3;STEL 0.4 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO THE CHEMICAL-air:10H TWA 0.2 mg/m3;STEL 0.4 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24100
No. of Facilities: 729 (estimated)
No. of Industries: 5
No. of Occupations: 6
No. of Employees: 2224 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24100
No. of Facilities: 436 (estimated)
No. of Industries: 9
No. of Occupations: 10
No. of Employees: 3502 (estimated)
No. of Female Employees: 1780 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLORODIMETHYLSILANE
RTECS NUMBER
: VV3150000
CHEMICAL NAME
: Silane, dichlorodimethylCAS REGISTRY NUMBER
: 75-78-5
BEILSTEIN REFERENCE NO. : 0605287
REFERENCE
: 4-04-00-04111 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C2-H6-Cl2-Si
MOLECULAR WEIGHT
: 129.07
WISWESSER LINE NOTATION : G-SI-G1&1
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Dichlorodimethylsilane
* Dichlorodimethylsilicon
* Dimethyl-dichlorsilan
* Dimethylsilane dichloride
* Inerton AW-DMCS
* LS 130
* Repel-Silan
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1219,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1219,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5660 uL/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Liver - other changes
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 12,573,1993
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 930 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1219,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,332,1948
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 3,23,1961
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83986
No. of Facilities: 54 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 170 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83986
No. of Facilities: 26 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 738 (estimated)
No. of Female Employees: 69 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROETHANE (1,1-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Aethylidenchlorid
:
:
:
:
:
:
:
:
:
KI0175000
Ethane, 1,1-dichloro75-34-3
199907
46
C2-H4-Cl2
98.96
GYG1
Tumorigen
Mutagen
Reproductive Effector
*
*
*
*
*
*
*
*
*
*
*
*
Chlorinated hydrochloric ether
Chlorure d'ethylidene
Cloruro di etilidene
1,1-Dichloorethaan
1,1-Dichloraethan
1,1-Dichlorethane
1,1-Dichloroethane
1,1-Dicloroetano
Ethylidene chloride
Ethylidene dichloride
NCI-C04535
RCRA waste number U076
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 725 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
32(3),349,1967
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 13000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A180-198
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 240 gm/kg/12W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Related to Chronic Data - death
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 6,313,1986
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - mouse
DOSE/DURATION
: 185 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-66,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1300 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-66,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6000 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,452,1974
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 2000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
201,401,1988
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 13 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
221,263,1989
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 405 mg/m3 (100 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40(3),A46,1979
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB82-182809
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 200 ppm (320 mg/m3)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,15,1973
OSHA PEL (Gen Indu):8H TWA 100 ppm (400 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 100 ppm (400 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 100 ppm (400 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 100 ppm (400 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt JAN 1993
OEL-AUSTRIA: MAK 100 ppm (400 mg/m3), JAN1999
OEL-AUSTRALIA:TWA 200 ppm (810 mg/m3);STEL 250 ppm (1010 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 100 ppm (400 mg/m3) JAN 1993
OEL-BELGIUM:TWA 200 ppm (810 mg/m3);STEL 250 ppm (1010 mg/m3) JAN 1993
OEL-FINLAND:TWA 100 ppm (400 mg/m3);STEL 250 ppm (1000 mg/m3) JAN 1993
OEL-JAPAN: OEL 100 ppm (400 mg/m3), JAN1999
OEL-GERMANY:TWA 100 ppm (400 mg/m3) JAN 1993
OEL-JAPAN:TWA 100 ppm (400 mg/m3) JAN 1993
OEL-POLAND: TWA 50 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 200 ppm (820 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 100 ppm (400 mg/m3) JAN 1993
OEL-RUSSIA:TWA 100 ppm JAN 1993
OEL-SWITZERLAND:TWA 100 ppm (400 mg/m3);STEL 200 ppm (800 mg/m3) JAN 1993
OEL-THAILAND:TWA 50 ppm;STEL 100 ppm JAN 1993
OEL-TURKEY:TWA 100 ppm (400 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 200 ppm (810 mg/m3);STEL 400 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 1,1-DICHLOROETHANE-air:10H TWA 100 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24120
No. of Facilities: 143 (estimated)
No. of Industries: 7
No. of Occupations: 9
No. of Employees: 715 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24120
No. of Facilities: 10 (estimated)
No. of Industries: 2
No. of Occupations: 7
No. of Employees: 1957 (estimated)
No. of Female Employees: 272 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Bioassay (gavage);equivocal evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-66,1978
DICHLOROETHANE (1,2,CIS-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
KV9420000
Ethylene, 1,2-dichloro-, (Z)156-59-2
1071208
4-01-00-00707 (Beilstein Handbook Reference)
199907
13
C2-H2-Cl2
96.94
G1U1G -Z
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* cis-1,2-Dichloroethene
* (Z)-1,2-Dichloroethene
* cis-Dichloroethylene
* cis-1,2-Dichloroethylene
* Ethene, 1,2-dichloro-, (Z)* HCC 1130c
* R 1130c
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LCLo - Lowest published lethal concentration
: Inhalation
: Rodent - mouse
DOSE/DURATION
: 65 gm/m3/2H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
REFERENCE :
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.)
V.101-154, 1929-71. For publisher information, see ZHPMAT.
Volume(issue)/page/year: 116,131,1936
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 20 gm/m3/6H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.)
V.101-154, 1929-71. For publisher information, see ZHPMAT.
Volume(issue)/page/year: 116,131,1936
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mmol/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
4,365,1984
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 40 mmol/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
4,365,1984
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 4300 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1629,1984
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Host-mediated assay
: Rodent - mouse Yeast - Saccharomyces cerevisiae
: 1300 mg/kg
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
4,365,1984
(Alan R. Liss,
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-DENMARK: TWA 200 ppm (790 mg/m3), JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5352
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 61 (estimated)
No. of Female Employees: 6 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; test completed (peer review), May 1999
DICHLOROETHANE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Aethylenchlorid
* 1,2-Bichloroethane
:
:
:
:
:
:
:
:
:
KI0525000
Ethane, 1,2-dichloro107-06-2
199907
134
C2-H4-Cl2
98.96
G2G
Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Bichlorure d'ethylene
Borer sol
Brocide
Chlorure d'ethylene
Cloruro di ethene
1,2-DCE
Destruxol borer-sol
1,2-Dichloorethaan
1,2-Dichlor-aethan
Dichloremulsion
1,2-Dichlorethane
Di-chlor-mulsion
Dichloro-1,2-ethane
alpha,beta-Dichloroethane
sym-Dichloroethane
1,2-Dichloroethane
Dichloroethylene
1,2-Dicloroetano
Dutch liquid
Dutch oil
EDC
ENT 1,656
Ethane dichloride
Ethyleendichloride
Ethylene chloride
Ethylene dichloride
1,2-Ethylene dichloride
Glycol dichloride
NCI-C00511
RCRA waste number U077
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 625 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/23/1970
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,93,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration into the eye
: Rodent - rabbit
DOSE/DURATION
: 63 mg
REACTION SEVERITY
: Severe
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 3/23/1970
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,93,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 4000 ppm/1H
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - coma
Gastrointestinal - nausea or vomiting
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,500,1966
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 286 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - nausea or vomiting
Liver - fatty liver degeneration
REFERENCE :
CLCEAL Casopis Lekaru Ceskych. Journal of Czech Physicians. (ARTIA, Ve
Smeckach 30, 111 27 Prague 1, Czeckoslovakia) V.11862Volume(issue)/page/year: 86,203,1947
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 428 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - cough
Gastrointestinal - nausea or vomiting
REFERENCE :
SOMEAU Sovetskaia Meditsina. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11937- Volume(issue)/page/year: 22(10),132,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 892 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Liver - jaundice, other or unclassified
REFERENCE :
WILEAR Wiadomosci Lekarskie. Medical News. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11948- Volume(issue)/page/year: 28,983,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 714 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Cardiac - change in rate
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.11922- Volume(issue)/page/year:
48,822,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C130,1991
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/7H
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - cyanosis
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,482,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 807 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 26(4),26,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - general anesthetic
Behavioral - ataxia
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 48A,91,1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520615
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 413 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Liver - other changes
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 43,41,1982
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 141,19,1929
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
470 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 11,902,1961
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,53,1945
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 5700 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - general anesthetic
Behavioral - ataxia
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 48A,91,1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 3000 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,93,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LC - Lethal concentration
: Inhalation
: Mammal - cat
DOSE/DURATION
: >3000 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,53,1945
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information
Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year:
6,264,1973
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3000 ppm/7H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,53,1945
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2800 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - general anesthetic
Behavioral - ataxia
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 48A,91,1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - pig
DOSE/DURATION
: 3000 ppm/7H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,53,1945
V.1-
1909/10-
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1500 ppm/7H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.11909/10Volume(issue)/page/year: 84,53,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
35,21,1974
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: >3000 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,53,1945
V.1-
1909/10-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 21840 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3123
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg/10-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 17,463,1994
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 ppm/7H/6W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28(4),113,1946
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 ppm/7H/5D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.11909/10Volume(issue)/page/year: 84,53,1945
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
43680 mg/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3123
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 ppm/7H/9D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28(4),113,1946
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 685 mg/kg/14D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 43,41,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1500 ppm/7H/5D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage
Related to Chronic Data - death
REFERENCE :
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St.,
Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.641960Volume(issue)/page/year: 32,391,1944
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 1000 ppm/7H/9W-I
TOXIC EFFECTS :
Behavioral - coma
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28(4),113,1946
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 1000 ppm/7H/11W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28(4),113,1946
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 400 ppm/7H/19W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28(4),113,1946
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 ppm/7H/25W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28(4),113,1946
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1500 ppm/7H/5D-I
TOXIC EFFECTS :
Cardiac - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.11909/10Volume(issue)/page/year: 84,53,1945
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5286 mg/kg/69W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
REFERENCE :
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold
Spring
Harbor, NY 11724) V.11979- Volume(issue)/page/year: 5,35,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 ppm/7H/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - leukemia
Skin and Appendages - tumors
REFERENCE :
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold
Spring
Harbor, NY 11724) V.11979- Volume(issue)/page/year: 5,3,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3536 mg/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold
Spring
Harbor, NY 11724) V.11979- Volume(issue)/page/year: 5,35,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 ppm/7H/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold
Spring
Harbor, NY 11724) V.11979- Volume(issue)/page/year: 5,3,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1120 gm/kg/74W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 63,1433,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 38 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Vascular - tumors
Gastrointestinal - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-55,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 76 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-55,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Vascular - tumors
Gastrointestinal - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-55,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 38 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-55,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 300 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold
Spring
Harbor, NY 11724) V.11979- Volume(issue)/page/year: 5,149,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
208 mg/m3/6H
female 2 week(s) pre-mating
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive
Medicine.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) Beginning history not known. Volume(issue)/page/year:
23,199,1989
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 umol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
34,2576,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 ug/plate
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 15,101,1987
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 7060 umol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,190,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 316 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19,98,1992
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mg/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
34,2576,1974
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
57,163,1978
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 250 mg/m3
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
252,17,1991
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 120 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
285,209,1993
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 2 ppm/96H (Continuous)
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring
St.,
New York, NY 10013) V.11972- Volume(issue)/page/year: 32,65,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 2000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1201,401,1988
1964-
Volume(issue)/page/year:
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 mL/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
13,213,1981
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
142,133,1985
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 150 mg/kg
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,190,1982
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 150 ppm/6H
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
62,190,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 130 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
221,263,1989
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
117,201,1983
TYPE OF TEST
ROUTE OF EXPOSURE
: DNA damage
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 mmol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 4,1491,1983
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
44,4267,1984
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 29 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
163,193,1986
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION
: 80 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
24,265,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 2 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
90,183,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 200 uL/plate
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring
St.,
New York, NY 10013) V.11972- Volume(issue)/page/year: 25,75,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 gm/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(103),64,1985
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 40 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
90,183,1981
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 40 mg/m3 (10 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,429,1979
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,429,1979
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1-
1946-
Volume(issue)/page/year: 38,409,1965
TOXICOLOGY REVIEW
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40(3),A46,1979
TOXICOLOGY REVIEW
VHTODE Veterinary and Human Toxicology.
and
(American College of Veterinary
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.191977- Volume(issue)/page/year: 22,31,1980
TOXICOLOGY REVIEW
DCTODJ Drug and Chemical Toxicology.
(Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.1-
1977/78-
Volume(issue)/page/year: 5,319,1982
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB82-182825
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 50 ppm (200 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,79,1971
OSHA PEL (Gen Indu):8H TWA 50 ppm;CL 100 ppm;Pk 200 ppm/5M/3H
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 50 ppm (200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 50 ppm (200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 50 ppm (200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 5 ppm (2 mg/m3) JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 10 ppm (40 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 20 ppm (80 mg/m3) JAN 1993
OEL-BELGIUM:TWA 10 ppm (40 mg/m3) JAN 1993
OEL-FINLAND:TWA 10 ppm (40 mg/m3);STEL 20 ppm (80 mg/m3);Carcinogen JAN
1993
OEL-JAPAN: OEL 10 ppm (40 mg/m3), 2B Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 4 mg/m3;Carcinogen JAN 1993
OEL-POLAND: TWA 50 mg/m3, STEL 60 mg/m3, JAN1999
OEL-JAPAN:TWA 10 ppm (40 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 50 ppm (200 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 50 ppm (200 mg/m3) JAN 1993
OEL-RUSSIA:TWA 10 ppm JAN 1993
OEL-SWEDEN:TWA 1 ppm (4 mg/m3);STEL 5 ppm (20 mg/m3);Skin;Carcinogen JAN
1993
OEL-SWITZERLAND:TWA 10 ppm (40 mg/m3);STEL 20 ppm (80 mg/m3) JAN 1993
OEL-TURKEY:TWA 50 ppm (200 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (40 mg/m3);STEL 15 ppm (60 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ETHYLENE DICHLORIDE-air:10H CA TWA 1 ppm;STEL 2 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24130
No. of Facilities: 7148 (estimated)
No. of Industries: 92
No. of Occupations: 60
No. of Employees: 77671 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24130
No.
No.
No.
No.
No.
of
of
of
of
of
Facilities: 2226 (estimated)
Industries: 38
Occupations: 61
Employees: 83246 (estimated)
Female Employees: 33361 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/171422/AS
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell
transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-nondisjunction; E coli
polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN 25, 1978, AND BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-55,1978
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
NTP Toxicity studies, RPT# TOX-04, May 1999
OSHA ANALYTICAL METHOD #03
DICHLOROINDOPHENOL SODIUM (2,6-)
RTECS NUMBER
: GU5495000
CHEMICAL NAME
: 2,5-Cyclohexadien-1-one,
2,6-dichloro-4-((p-hydroxyphenyl)imino)-, sodium
salt
CAS REGISTRY NUMBER
: 620-45-1
LAST UPDATED
: 199709
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C12-H6-Cl2-N-O2.Na
MOLECULAR WEIGHT
: 290.08
WISWESSER LINE NOTATION : L6V DYJ BG DUNR DQ& FG &-NACOMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 2,6-Dichloro-4-((p-hydroxyphenyl)imino)-2,5-cyclohexadien-1-one sodium
salt
* 2,6-Dichloroindophenol, sodium salt
* Indophenol, 2,6-dichloro-, sodium salt
* Sodium 2,6-dichloroindophenol
* Sodium 2,6-dichloroindophenolate
* Sodium,
(p-((3,5-dichloro-4-oxo-2,5-cyclohexadien-1-ylidene)amino)phenoxyl)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.91974- Volume(issue)/page/year: 17,349,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04765
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DICHLOROISOCYANURIC ACID SODIUM
RTECS NUMBER
: XZ1900000
CHEMICAL NAME
: s-Triazine-2,4,6(1H,3H,5H)-trione, dichloro-,
sodium
salt
CAS REGISTRY NUMBER
: 2893-78-9
LAST UPDATED
: 199806
DATA ITEMS CITED
: 17
MOLECULAR FORMULA
: C3-H-Cl2-N3-O3.Na
MOLECULAR WEIGHT
: 220.96
WISWESSER LINE NOTATION : T6MVNVNVJ CG GG &-NACOMPOUND DESCRIPTOR
: Agricultural Chemical
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* ACL 60
* CDB 63
* CP 17254
* Dichloroisocyanuric acid sodium salt
* Dichlorosymtriazine-2,4,6(1H,3H,5H)trione sodium derivative
* Dikonit
* Dimanin C
* Fi Clor 60S
* Isocyanuric acid, dichloro-, sodium salt
* OCI 56
* SDIC
* Simpla
* Sodium dichlorocyanurate
* Sodium dichlorisocyanurate
* Sodium dichloroisocyanurate
* 1-Sodium-3,5-dichloro-s-triazine-2,4,6-trione
* 1-Sodium-3,5-dichloro-1,3,5-triazine-2,4,6-trione
* Sodium salt of dichloro-s-triazinetrione
* 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3-dichloro-, sodium salt
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals
Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE
19810)
Volume(issue)/page/year: -,-,1972
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
REFERENCE :
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rabbit
500 mg
Severe
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,167,1969
TYPE OF TEST
: Rinsed with water
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals
Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE
19810)
Volume(issue)/page/year: -,-,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555174
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 3570 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,167,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1420 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - acute pulmonary edema
Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555174
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - coma
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals
Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE
19810)
Volume(issue)/page/year: -,-,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3160 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - pulmonary emboli
Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555174
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,959,1980
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Effects on Newborn - physical
REFERENCE :
YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14,
1968-81. Suspended. Volume(issue)/page/year: 13,353,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
Reproductive - Effects on Newborn - physical
REFERENCE :
YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan)
1968-81. Suspended. Volume(issue)/page/year: 13,23,1980
V.1-14,
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1492
No. of Facilities: 6526 (estimated)
No. of Industries: 29
No. of Occupations: 27
No. of Employees: 39204 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1492
No. of Facilities: 3499 (estimated)
No. of Industries: 33
No. of Occupations: 38
No. of Employees: 53851 (estimated)
No. of Female Employees: 24172 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9201
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROMETHANE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
PA8050000
Methane, dichloro75-09-2
1730800
4-01-00-00035 (Beilstein Handbook Reference)
199907
121
C-H2-Cl2
84.93
G1G
Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aerothene MM
* Chlorure de methylene
* Dichloromethane
* Methane dichloride
* Methylene bichloride
* Methylene chloride
* Methylene dichloride
* Metylenu chlorek
* Narkotil
* NCI-C50102
* R 30
* R30 (refrigerant)
* RCRA waste number U080
* Solaesthin
* Solmethine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 810 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,171,1976
(Paris,
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,88,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 162 mg
REACTION SEVERITY
: Moderate
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,171,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration into the eye
: Rodent - rabbit
(Paris,
DOSE/DURATION
: 10 mg
REACTION SEVERITY
: Mild
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 6,173,1976
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,88,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 357 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,390,1969
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 500 ppm/1Y-I
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Cardiac - change in rate
REFERENCE :
ABHYAE Abstracts on Hygiene. (Bureau of Hygiene and Tropical Diseases,
Keppel St., London WC1E 7HT, UK) V.11926- Volume(issue)/page/year:
43,1123,1968
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 500 ppm/8H
TOXIC EFFECTS :
Behavioral - euphoria
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
176,295,1972
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 48A,94,1970
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 52 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 15,64,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 916 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 40,411,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 350 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520615
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(6),78,1988
TYPE OF TEST
ROUTE OF EXPOSURE
: LC50 - Lethal concentration, 50 percent kill
: Inhalation
(V/O
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14400 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
Volume(issue)/page/year: 191,1,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 437 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 18,109,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
4,354,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4770 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11953Volume(issue)/page/year: 28,P31,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
ROUTE OF EXPOSURE
: LCLo - Lowest published lethal concentration
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 14108 ppm/7H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
Volume(issue)/page/year: 191,1,1949
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 950 mg/kg
TOXIC EFFECTS :
Liver - liver function tests impaired
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,119,1967
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 43400 mg/m3/4.5H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.)
V.101-154, 1929-71. For publisher information, see ZHPMAT.
Volume(issue)/page/year: 116,131,1936
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,94,1955
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10000 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,8,1944
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
7,205,1934
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(6),78,1988
(V/O
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5000 ppm/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FLCRAP Fluorine Chemistry Reviews. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.11967- Volume(issue)/page/year: 1,197,1967
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 91 gm/kg/2Y-C
TOXIC EFFECTS :
Behavioral - fluid intake
Liver - fatty liver degeneration
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
24,951,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3700 ppm/5H/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year: 7,41,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5000 ppm/24H/14W-C
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD746-295
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8400 ppm/6H/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-306,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 44 mg/m3/24H/96D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 40(9),105,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 39270 mg/kg/17W-I
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 26(5),41,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1862 mg/kg/2W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 6,563,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13000 ppm/6H/19D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-306,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 150 ppm/24H/30D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
59,73,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - mouse
5000 ppm/24H/7D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,660,1972
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 ppm/24H/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
59,73,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1000 ppm/24H/7W-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Musculoskeletal - other changes
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD746-295
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 5000 ppm/24H/32D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD746-295
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 552 ppm/6H/5D-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
37,345,1976
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3500 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 4,30,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2000 ppm/5H/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-306,1986
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4500 ppm/24H
SEX/DURATION
: female 1-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
52,29,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1250 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
32,84,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1250 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
32,84,1975
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 5700 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
56,245,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 6300 ppm
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
20,211,1992
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 8250 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,349,1991
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 125 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
90,91,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 5000 ppm/1H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
81,203,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 160 umol/L
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 14,290,1978
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1275 mg/kg
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
9,61,1989
(Alan R. Liss,
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 30 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 15,991,1994
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 27760 mg/m3/6H/2W (Intermittent)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
15,221,1990
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 400 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 15,991,1994
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 4000 ppm/6H (Continuous)
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 15,991,1994
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: DNA damage
: Oral
: Rodent - mouse
DOSE/DURATION
: 1720 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
419,13,1998
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 27760 mg/m3/6H/2W (Intermittent)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
15,221,1990
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 13880 mg/m3/6H/2W (Intermittent)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
15,221,1990
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1300 uL/plate
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring
St.,
New York, NY 10013) V.11972- Volume(issue)/page/year: 25,75,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 3000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
367,143,1996
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 5000 ppm/1H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
81,203,1981
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 6628 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
116,361,1983
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 13,205,1987
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 6628 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
116,361,1983
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 5000 ppm/1H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
81,203,1981
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 3000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
367,143,1996
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 174 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 41,43,1986
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 41,43,1986
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,194,1987
TOXICOLOGY REVIEW
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug
Research.
(Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
Secaucus, NJ 07094) V.11959- Volume(issue)/page/year: 18,365,1974
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 500 ppm (1750 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,171,1971
OSHA PEL (Gen Indu):8H TWA 500 ppm;CL 1000 ppm;Pk 2000 ppm/5M/2H
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):see 56 FR 57036
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
OSHA PEL (Shipyard):8H TWA 500 ppm (1740 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 500 ppm (1740 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 100 ppm (350 mg/m3);Carcinogen JAN 1993
OEL-AUSTRIA: MAK 100 ppm (360 mg/m3), Suspected Carcinogen, JAN1999
OEL-AUSTRIA:TWA 100 ppm (360 mg/m3) JAN 1993
OEL-BELGIUM:TWA 50 ppm (174 mg/m3);Carcinogen JAN 1993
OEL-DENMARK: TWA 35 ppm (122 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 100 ppm (350 mg/m3);STEL 250 ppm (870 mg/m3) JAN 1993
OEL-JAPAN: OEL 50 ppm (170 mg/m3), JAN1999
OEL-GERMANY:TWA 100 ppm (360 mg/m3);Carcinogen JAN 1993
OEL-HUNGARY:STEL 10 mg/m3;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 20 mg/m3, STEL 50 mg/m3, JAN1999
OEL-JAPAN:TWA 100 ppm (350 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 100 ppm (350 mg/m3);STEL 500 ppm JAN 1993
OEL-THE PHILIPINES:TWA 500 ppm (1740 mg/m3) JAN 1993
OEL-RUSSIA:TWA 100 ppm;STEL 50 mg/m3 JAN 1993
OEL-SWEDEN:TWA 35 ppm (120 mg/m3);STEL 70 ppm (250 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 100 ppm (360 mg/m3);STEL 500 ppm JAN 1993
OEL-THAILAND:TWA 500 mg/m3;STEL 1000 mg/m3 JAN 1993
OEL-TURKEY:TWA 500 ppm (1740 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 100 ppm (350 mg/m3);STEL 250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHYLENE CHLORIDE-air:CA lowest feasible concentration
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 47270
No. of Facilities: 89025 (estimated)
No. of Industries: 374
No. of Occupations: 192
No. of Employees: 975696 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 47270
No. of Facilities: 87086 (estimated)
No. of Industries: 363
No. of Occupations: 212
No. of Employees: 1438196 (estimated)
No. of Female Employees: 352536 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/89/194468/AS
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH CURRENT INTELLIGENCE BULLETIN 46, 1986
NIOSH Analytical Method, 1994: Methylene chloride, 1005
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenesis Studies (inhalation);clear evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-306,1986
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
OSHA ANALYTICAL METHOD #ID-59
DICHLOROMETHYL METHYL ETHER (ALPHA,ALPHA-)
RTECS NUMBER
: KN8150000
CHEMICAL NAME
: Ether, dichloromethyl methyl
CAS REGISTRY NUMBER
: 4885-02-3
BEILSTEIN REFERENCE NO. : 1900293
LAST UPDATED
: 199712
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C2-H4-Cl2-O
MOLECULAR WEIGHT
: 114.96
WISWESSER LINE NOTATION : GYGO1
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* 1,1-Dichlorodimethyl ether
* alpha,alpha-Dichloromethyl ether
* alpha,alpha-Dichloromethyl methyl ether
* Methoxydichloromethane
* Methane, dichloromethoxy*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.11877Volume(issue)/page/year: 163,633,1969
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLORONAPHTHOQUINONE (2,3-)
RTECS NUMBER
: QL7525000
CHEMICAL NAME
: 1,4-Naphthoquinone, 2,3-dichloroCAS REGISTRY NUMBER
: 117-80-6
LAST UPDATED
: 199710
DATA ITEMS CITED
: 14
MOLECULAR FORMULA
: C10-H4-Cl2-O2
MOLECULAR WEIGHT
: 227.04
WISWESSER LINE NOTATION : L66 BV EVJ CG DG
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Drug
SYNONYMS/TRADE NAMES :
* Algistat
* Compound 604
* Dichlone
* 2,3-Dichlor-1,4-naftochinon
* 2,3-Dichloro-1,4-naphthalenedione
* 2,3-Dichloro-1,4-naphthaquinone
* 2,3-Dichlor-1,4-naphthochinon
* Dichloronaphthoquinone
* 2,3-Dichloronaphthoquinone
* 2,3-Dichloro-alpha-naphthoquinone
* 2,3-Dichloro-1,4-naphthoquinone
* 2,3-Dichloronaphthoquinone-1,4
* ENT 3,776
* Latka 604
* Phygon
* Phygon paste
* Phygon seed protectant
* Phygon XL
* Quintar
* Quintar 540F
* Sanquinon
* Uniroyal
* USR 604
* U.S. Rubber 604
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 16(5),52,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982
Volume(issue)/page/year: -,47,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 26,570,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86
Volume(issue)/page/year:
A137,1983
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6 gm/kg/60D-C
TOXIC EFFECTS :
Liver - other changes
Biochemical - Metabolism (Intermediary) - glycolytic
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 35,23,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg/10D-I
TOXIC EFFECTS :
Liver - other changes
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 16(5),52,1972
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1300 mg/kg/13W-I
TOXIC EFFECTS :
Liver - other changes
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 16(5),52,1972
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3300 mg/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 22 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLORONITRO PYRIMIDINE (4,6:5-)
RTECS NUMBER
: UV8258000
CHEMICAL NAME
: Pyrimidine, 4,6-dichloro-5-nitroCAS REGISTRY NUMBER
: 4316-93-2
BEILSTEIN REFERENCE NO. : 0162029
REFERENCE
: 4-23-00-00899 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C4-H-Cl2-N3-O2
MOLECULAR WEIGHT
: 193.98
WISWESSER LINE NOTATION : T6N CNJ DG ENW FG
SYNONYMS/TRADE NAMES :
* 4,6-Dichloro-5-nitropyrimidine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#12158
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DICHLOROPENTANE (1,5-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
:
:
:
:
:
:
:
:
:
:
SA0350000
Pentane, 1,5-dichloro628-76-2
1732340
4-01-00-00310 (Beilstein Handbook Reference)
199701
2
C5-H10-Cl2
141.05
G5G
* 1,5-Dichloropentane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 2,189,1950
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DICHLOROPHENOL (2,4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
SK8575000
Phenol, 2,4-dichloro120-83-2
0742467
4-06-00-00885 (Beilstein Handbook Reference)
199904
36
C6-H4-Cl2-O
163.00
QR BG DG
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2,4-DCP
* 2,4-Dichlorohydroxybenzene
* 2,4-Dichlorophenol
* NCI-C55345
* RCRA waste number U081
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration onto the skin
: Rodent - rabbit
DOSE/DURATION
: 500 uL/24H
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534822
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 47 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534822
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 430 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 13,20,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1730 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 2,76,1943
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1276 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2
Volume(issue)/page/year: 5,478,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 153 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 18,868,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3160 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Lungs, Thorax, or Respiration - pulmonary emboli
Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534822
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 7,321,1959/1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 464 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(10),16,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 790 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936-
(V/O
(V/O
Volume(issue)/page/year: 45(10),16,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 91 gm/kg/13W-C
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-353,1989
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 31770 mg/kg/90D-C
TOXIC EFFECTS :
Behavioral - fluid intake
Blood - changes in cell count (unspecified)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 5,478,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 437 gm/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-353,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 67200 mg/kg/14D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-353,1989
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
(Research
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 16 gm/kg/39W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
19,413,1959
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 20 mg/kg
SEX/DURATION
: female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(11),102,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 4,167,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 7500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 13,635,1989
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
666 mg/kg
female 6-14 day(s) after conception
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-160
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 333 ug/plate
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-353,1989
(Research
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 200 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
24,181,1994
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 30 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-353,1989
(Research
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1200 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
400,169,1998
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1400 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
400,169,1998
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 3100 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
(Research
Triangle Park, NC 27709) No.206NTP-TR-353,1989
Volume(issue)/page/year:
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,135,1987
*** REVIEWS ***
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 41,319,1986
TOXICOLOGY REVIEW
STEVA8 Science of the Total Environment.
(Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands)
Volume(issue)/page/year:
2,305,1974
V.1-
1972-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4154
No. of Facilities: 6 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 63 (estimated)
No. of Female Employees: 23 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9261
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (feed);no evidence:rat,mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-353,1989
(Research
DICHLOROPHENOL (2,6-)
RTECS NUMBER
: SK8750000
CHEMICAL NAME
: Phenol, 2,6-dichloroCAS REGISTRY NUMBER
: 87-65-0
BEILSTEIN REFERENCE NO. : 1447806
REFERENCE
: 4-06-00-00949 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C6-H4-Cl2-O
MOLECULAR WEIGHT
: 163.00
WISWESSER LINE NOTATION : QR BG FG
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* 2,6-Dichlorfenol
* 2,6-Dichlorophenol
* RCRA waste number U082
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,524,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,524,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 390 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy.
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 13,20,1958
(London, UK)
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2120 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
29,39,1985
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROPHENYL DIMETHYLUREA
RTECS NUMBER
: YS8925000
CHEMICAL NAME
: Urea, 3-(3,4-dichlorophenyl)-1,1-dimethylCAS REGISTRY NUMBER
: 330-54-1
OTHER CAS REGISTRY NOS. : 102962-29-8
BEILSTEIN REFERENCE NO. : 2215168
REFERENCE
: 4-12-00-01263 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 35
MOLECULAR FORMULA
: C9-H10-Cl2-N2-O
MOLECULAR WEIGHT
: 233.11
WISWESSER LINE NOTATION : GR BG DMVN1&1
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* AF 101
* DCMU
* Dichlorfenidim
* 3-(3,4-Dichlorophenol)-1,1-dimethylurea
* N'-(3,4-Dichlorophenyl)-N,N-dimethylurea
* 3-(3,4-Dichlorophenyl)-1,1-dimethylurea
* 1-(3,4-Dichlorophenyl)-3,3-dimethyluree
* 3-(3,4-Dichlor-phenyl)-1,1-dimethyl-harnstoff
* 3-(3,4-Dichloor-fenyl)-1,1-dimethylureum
* 3-(3,4-Dicloro-fenyl)-1,1-dimetil-urea
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
1,1-Dimethyl-3-(3,4-dichlorophenyl)urea
Direx 4L
Diuron
Diuron
Diuron 4L
DMU
DP Hardener 95
Duran
Farmco diuron
Herbatox
HW 920
Karmex
Karmex Diuron Herbicide
Karmex DW
Lucenit
Marmer
Sup'r flo
Telvar diuron weed killer
Unidron
USAF P-7
USAF XR-42
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1017 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - ataxia
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 18,1104,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C115,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,
Springer-Verlag
New York, Inc., 1971
Volume(issue)/page/year: -,231,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Bird - duck
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C115,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 52500 ug/kg/30D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
36,76,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 13620 mg/kg/61W-C
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
31,285,1993
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 90 mg/m3/4H/60D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Blood - changes in spleen
Endocrine - changes in thyroid weight
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 34(6),27,1969
(V/O
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 153 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 360 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(8),83,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1250 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 22,522,1979
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1935 mg/kg
SEX/DURATION
: female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-160
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 3 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,353,1978
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,353,1978
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 10 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
CNDQA8 Cahiers de Nutrition et de Dietetique.
(Editions Meteore, 42, rue
du
Louvre, 75001 Paris, France)
10(3),43,1975
V.1-
1966-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
OEL-DENMARK: TWA 5 mg/m3, JAN1999
OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 10 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIURON-air:10H TWA 10 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0785
No. of Facilities: 120 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 374 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0785
No. of Facilities: 75 (estimated)
No. of Industries: 8
No. of Occupations: 12
No. of Employees: 4216 (estimated)
No. of Female Employees: 264 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROPROPANE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
TX9625000
Propane, 1,2-dichloro78-87-5
1718880
3-01-00-00225 (Beilstein Handbook Reference)
199907
72
C3-H6-Cl2
112.99
GY1&1G
Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bichlorure de propylene
* alpha,beta-Dichloropropane
* 1,2-Dichloropropane
* Dwuchloropropan
* ENT 15,406
* NCI-C55141
* Propylene chloride
* Propylene dichloride
* alpha,beta-Propylene dichloride
* RCRA waste number U083
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
DOSE/DURATION
: 1947 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
20,364,1959
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14 gm/m3/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
20,364,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
63,445,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,98,1986
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1000 ppm/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28,1,1946
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Unreported
Rodent - mouse
960 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11953Volume(issue)/page/year: 28,P31,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Behavioral - sleep
Liver - other changes
REFERENCE :
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64.
For
publisher information, see AJEPAS. Volume(issue)/page/year: 16,325,1932
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 8750 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/28/1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C253,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28 gm/kg/14D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-263,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
(Research
DOSE/DURATION
: 109 mg/kg/26W-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other hydrolases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(1),94,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16250 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 12,713,1989
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9 mg/m3/24H/94D-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(8),50,1977
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/m3/24H/60D-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 47(10),21,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
1000 ppm/7H/20W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Blood - changes in spleen
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28(1),1,1946
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2500 mg/kg/5D-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
63,445,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1400 mg/kg/4W-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
63,445,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 28 gm/kg/14D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-263,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32500 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
(Research
(Research
Triangle Park, NC 27709) No.206NTP-TR-263,1986
Volume(issue)/page/year:
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 ppm/7H/7W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30(3),189,1948
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1000 ppm/7H/26W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Endocrine - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28(1),1,1946
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1500 ppm/7H/8W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Endocrine - other changes
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 28(1),1,1946
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 130 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-263,1986
(Research
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1250 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 28,18,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 1950 mg/kg
SEX/DURATION
: female 7-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 28,18,1995
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 11600 ug/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 660 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-263,1986
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EMMUEG Environmental
(Research
: Sister chromatid exchange
: Rodent - hamster Ovary
: 113 mg/L
and Molecular Mutagenesis.
(Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003)
10(Suppl 10),1,1987
V.10-
1987-
Volume(issue)/page/year:
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 3300 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 508 mg/m3 (110 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 347 mg/m3 (75 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 41,131,1986
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 41,131,1986
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St.,
Baltimore, MD 21202) V.11949- Volume(issue)/page/year: 4,1,1952
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 75 ppm (350 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,218,1971
OSHA PEL (Gen Indu):8H TWA 75 ppm (350 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 75 ppm (350 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 75 ppm (350 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 75 ppm (350 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 75 ppm (350 mg/m3);STEL 110 ppm (510 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 75 ppm (350 mg/m3), JAN1999
OEL-AUSTRIA:TWA 75 ppm (350 mg/m3) JAN 1993
OEL-BELGIUM:TWA 75 ppm (347 mg/m3);STEL 110 ppm (509 mg/m3) JAN 1993
OEL-DENMARK: TWA 75 ppm (350 mg/m3), JAN1999
OEL-FINLAND:TWA 75 ppm (350 mg/m3);STEL 115 ppm (530 mg/m3) JAN 1993
OEL-GERMANY:TWA 75 ppm (350 mg/m3) JAN 1993
OEL-HUNGARY:TWA 50 mg/m3;STEL 100 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 75 ppm (350 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 50 mg/m3, STEL 400 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 75 ppm (350 mg/m3) JAN 1993
OEL-RUSSIA:STEL 10 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 75 ppm (350 mg/m3);STEL 375 ppm (1750 mg/m3) JAN 1993
OEL-TURKEY:TWA 74 ppm (350 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO PROPYLENE DICHLORIDE-air:CA lowest feasible conc.
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24390
No. of Facilities: 653 (estimated)
No. of Industries: 13
No. of Occupations: 15
No. of Employees: 9601 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24390
No. of Facilities: 116 (estimated)
No. of Industries: 6
No. of Occupations: 15
No. of Employees: 2944 (estimated)
No. of Female Employees: 1022 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/182122/AS
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Propylene dichloride, 1013
NTP Carcinogenesis Studies (gavage);some evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-263,1986
NTP Carcinogenesis Studies (gavage);equivocal evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-263,1986
(Research
(Research
DICHLOROPROPANE (2,2-)
RTECS NUMBER
: TX9662500
CHEMICAL NAME
: Propane, 2,2-dichloroCAS REGISTRY NUMBER
: 594-20-7
LAST UPDATED
: 199906
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C3-H6-Cl2
MOLECULAR WEIGHT
: 112.99
SYNONYMS/TRADE NAMES :
* Dichlorodimethylmethane
* 2,2-Dichloropropane
* Dimethyldichloromethane
* R 270aa
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >3500 ppm/6H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535796
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROPROPANOL (1,3-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
:
:
:
:
UB1400000
2-Propanol, 1,3-dichloro96-23-1
1732063
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
4-01-00-01491 (Beilstein Handbook Reference)
199907
19
C3-H6-Cl2-O
128.99
G1YQ1G
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Dichlorohydrin
* alpha-Dichlorohydrin
* sym-Dichloroisopropyl alcohol
* 1,3-Dichloro-2-propanol
* Enodrin
* Glycerol alpha,gamma-dichlorohydrin
* sym-Glycerol dichlorohydrin
* U 25,354
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 125 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 69,203,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 800 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4550 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539378
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 umol/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 2,59,1980
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
200,785,1978
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Mutation test systems - not otherwise specified
: Bacteria - Escherichia coli
: 30 umol/tube
REFERENCE :
CBINA8 Chemico-Biological Interactions.
Ireland
Ltd., POB 85, Limerick, Ireland) V.180,73,1991
(Elsevier Scientific Pub.
1969-
Volume(issue)/page/year:
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 2500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
92,427,1982
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 250 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-GERMANY;Carcinogen JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5378
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 6
No. of Employees: 200 (estimated)
No. of Female Employees: 6 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROPROPANONE (1,3:2-)
RTECS NUMBER
: UC1430000
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
2-Propanone, 1,3-dichloro534-07-6
0605456
4-01-00-03219 (Beilstein Handbook Reference)
199710
23
C3-H4-Cl2-O
126.97
G1V1G
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bis(chloromethyl)ketone
* sym-Dichloroacetone
* alpha,alpha'-Dichloroacetone
* alpha,gamma-Dichloroacetone
* 1,3-Dichloro-2-propanone
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555373
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555373
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555373
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 29 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,44,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18900 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555373
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 27 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,44,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 53 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - iritis
Behavioral - somnolence (general depressed activity)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555373
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
720 mg/kg/90D-C
TOXIC EFFECTS :
Behavioral - fluid intake
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 16,341,1993
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 37500 ug/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
48,197,1989
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1250 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
157,111,1985
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,478,1983
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 300 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,1,1994
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 100 pph/8M
REFERENCE :
PREBA3 Proceedings of the Royal Society of Edinburgh, Section B.
(Edinburgh,
Scotland, UK) V.61-74, 1943-74.
62,284,1946/1947
Volume(issue)/page/year:
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 5 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
155,53,1985
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
155,53,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 50 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,1,1994
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 2 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROPROPENE (1,3-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
:
UC8310000
Propene, 1,3-dichloro542-75-6
68525-58-6
1719556
3-01-00-00704 (Beilstein Handbook Reference)
199907
48
C3-H4-Cl2
110.97
G2U1G
Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* alpha-Chloroallyl chloride
* gamma-Chloroallyl chloride
* 3-Chloroallyl chloride
* 3-Chloropropenyl chloride
* DD 95
* 1,3-Dichloropropene
* 1,3-Dichloropropene-1
* 1,3-Dichloro-2-propene
* 1,3-Dichloropropene
* alpha,gamma-Dichloropropylene
* 1,3-Dichloropropylene
* Dorlone II
* NCI-C03985
* RCRA waste number U084
* Telone
* Telone II
* Telone II soil fumigant
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and
Environment Research, Toxicology Research Lab., Midland, MI 48640)
Volume(issue)/page/year: MSD-405
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/2H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311)
38,217,1977
V.19-
1958-
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 775 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C103,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 5,2,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 8,562,1987
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4650 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,48,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 504 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and
Environment Research, Toxicology Research Lab., Midland, MI 48640)
Volume(issue)/page/year: MSD-405
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 400 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
38,217,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 455 mg/kg/26W-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other hydrolases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(1),94,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1365 mg/kg/13W-C
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 32,224,1996
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 90 ppm/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 11,207,1988
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
1365 mg/kg/13W-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 32,224,1996
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 90 ppm/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 11,207,1988
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15600 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-269,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 31200 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Kidney, Ureter, Bladder - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-269,1985
(Research
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 60 ppm/6H/5D/2Y
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 12,418,1989
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 33 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl
1),3,1983
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 umol/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 2,59,1980
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
203,81,1988
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5750 ppm
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,325,1985
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
419,13,1998
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 3 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST
TEST SYSTEM
: Cytogenetic analysis
: Rodent - hamster Ovary
DOSE/DURATION
: 49100 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
13,60,1989
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 900 nmol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.11959- Volume(issue)/page/year: 22,681,1980
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 4.5 mg/m3 (1 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 41,113,1986
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 41,113,1986
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,195,1987
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (5 mg/m3);Skin;Carcinogen JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-BELGIUM:TWA 1 ppm (4.5 mg/m3);Skin JAN 1993
OEL-DENMARK: TWA 1 ppm (5 mg/m3), Skin, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
OEL-SWITZERLAND;Carcinogen JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO 1,3-DICHLOROPROPENE-air:8H CA TWA 1 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3912
No. of Facilities: 48 (estimated)
No. of Industries: 3
No. of Occupations: 14
No. of Employees: 2162 (estimated)
No. of Female Employees: 33 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-269,1986
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
DICHLOROQUINOLINE (4,7-)
RTECS NUMBER
: VB4200000
CHEMICAL NAME
: Quinoline, 4,7-dichloroCAS REGISTRY NUMBER
: 86-98-6
BEILSTEIN REFERENCE NO. : 0125359
REFERENCE
: 5-20-07-00316 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C9-H5-Cl2-N
MOLECULAR WEIGHT
: 198.05
WISWESSER LINE NOTATION : T66 BNJ EG IG
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 4,7-Dichloroquinoline
* TL 1473
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research
and Development, Progress Report. Volume(issue)/page/year: 30101,8,1945
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
42,335,1977
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DICHLOROQUINOXALINE (2,3-)
RTECS NUMBER
: VD1720000
CHEMICAL NAME
: Quinoxaline, 2,3-dichloroCAS REGISTRY NUMBER
: 2213-63-0
BEILSTEIN REFERENCE NO. : 0126076
REFERENCE
: 5-23-07-00144 (Beilstein Handbook Reference)
LAST UPDATED
: 199806
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C8-H4-Cl2-N2
MOLECULAR WEIGHT
: 199.04
WISWESSER LINE NOTATION : T66 BN ENJ CG DG
SYNONYMS/TRADE NAMES :
* CP 42103-4
* 2,3-Dichloroquinoxaline
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 195 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Gastrointestinal - peritonitis
Kidney, Ureter, Bladder - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534573
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#03256
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROTOLUENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
CZ5075000
Benzene, (dichloromethyl)98-87-3
1099407
4-05-00-00817 (Beilstein Handbook Reference)
199907
22
C7-H6-Cl2
161.03
GYGR
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzal chloride
* Benzyl dichloride
* Benzylene chloride
* Chlorobenzal
* Chlorure de benzylidene
* (Dichloromethyl)benzene
* alpha,alpha-Dichlorotoluene
* RCRA waste number U017
* Toluene, alpha,alpha-dichloro*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3249 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 61 ppm/2H
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,65,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2462 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-72-62,1972
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 ppm/2H
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,65,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 40(1),92,1975
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 210 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(3),6,1986
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Administration onto the skin
Rodent - mouse
9200 mg/kg/50W-I
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research.
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
72,655,1981
(Tokyo, Japan)
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 35200 mg/kg/42W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
72,655,1981
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 600 nmol/plate/20M
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,143,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 600 nmol/plate/20M
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,143,1978
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 31 umol/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,143,1978
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.1-
1972-
Volume(issue)/page/year: 29,65,1982
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,65,1982
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-FINLAND;Carcinogen JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
OEL-SWEDEN;Carcinogen JAN 1993
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine
reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROTOLUENE (2,4-)
RTECS NUMBER
: XT0730000
CHEMICAL NAME
: Toluene, 2,4-dichloroCAS REGISTRY NUMBER
: 95-73-8
BEILSTEIN REFERENCE NO. : 1931691
REFERENCE
: 4-05-00-00815 (Beilstein Handbook Reference)
LAST UPDATED
: 199903
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C7-H6-Cl2
MOLECULAR WEIGHT
: 161.03
SYNONYMS/TRADE NAMES :
* Benzene, 2,4-dichloro-1-methyl* 2,4-Dichloro-1-methylbenzene
* 2,4-Dichlorotoluene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - muscle weakness
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(10),56,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - muscle weakness
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 25(10),56,1981
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537054
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(2),80,1988
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Oral
(V/O
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6440 mg/kg/2W-I
TOXIC EFFECTS :
Liver - other changes
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(11),86,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28980 mg/kg/9W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(2),80,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICHLOROXYLENE (ALPHA,ALPHA',PARA-)
RTECS NUMBER
: ZE4100000
CHEMICAL NAME
: p-Xylene, alpha,alpha'-dichloroCAS REGISTRY NUMBER
: 623-25-6
BEILSTEIN REFERENCE NO. : 0774706
REFERENCE
: 4-05-00-00967 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C8-H8-Cl2
MOLECULAR WEIGHT
: 175.06
WISWESSER LINE NOTATION : G1R D1G
COMPOUND DESCRIPTOR
: Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,4-Bis(chloromethyl)benzene
* CP 21645
* alpha,alpha'-Dichloro-p-xylene
* p-Xylylene dichloride
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Moderate
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,213,1969
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS054612
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1280 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546123
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 501 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546123
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Mutation in microorganisms
: Bacteria - Salmonella typhimurium
: 100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
191,79,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICYANDIAMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* ACR-H 3636
* Araldite HT 986
* Araldite XB 2879B
* Araldite XB 2979B
* Bakelite VE 2560
* Cyanoguanidine
* N-Cyanoguanidine
* 1-Cyanoguanidine
* Dicyandiamide
* Dicyandiamin
* Dicyanodiamide
* Epicure DICY 7
* Epicure DICY 15
* XB 2879B
:
:
:
:
:
:
:
ME9950000
Guanidine, cyano461-58-5
199903
13
C2-H4-N4
84.10
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,17,1953
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
14,1325,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (4),39,1998
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
8,329,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
8,329,1952
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 273 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(109),61,1991
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 ug/m3/4W-I
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (4),39,1998
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2400 ug/m3/4W-I
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (4),39,1998
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83038
No. of Facilities: 720 (estimated)
No. of Industries: 27
No. of Occupations: 55
No. of Employees: 19281 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83038
No. of Facilities: 1639 (estimated)
No. of Industries: 48
No. of Occupations: 50
No. of Employees: 35475 (estimated)
No. of Female Employees: 7043 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICYANOBENZENE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
TI8575000
Phthalonitrile
91-15-6
199710
15
C8-H4-N2
128.14
NCR BCN
Agricultural Chemical
Tumorigen
SYNONYMS/TRADE NAMES :
* 1,2-Benzendikarbonitril
* o-Dicyanobenzene
* 1,2-Dicyanobenzene
* Ftalodinitril
* Ftalonitril
* o-Pdn
* Phthalic acid dinitrile
* Phthalodinitrile
* o-Phthalodinitrile
* USAF ND-09
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 125 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt,
Fed.
Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 62 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KJMDA6 Kobe Journal of the Medical Sciences. (Kobe Univ. School of
Medicine, Kusunoki-cho, Chuo-ku, Kobe 650, Japan) V.11951Volume(issue)/page/year: 11,63,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 65 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan)
Volume(issue)/page/year:
4,11,1966
V.1-
1963-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 46 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
4,11,1966
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt,
Fed.
Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt,
Fed.
Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
7425 mg/kg/66W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Blood - leukemia
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 18(1),81,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 473 mg/kg/21W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Blood - leukemia
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 18(1),81,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 21 gm/kg/65W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Blood - leukemia
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 18(1),81,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 813 mg/kg/46W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - leukemia
Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 18(1),81,1972
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
7 gm/kg/63W-I
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - leukemia
Tumorigenic - tumors at site of application
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 18(1),81,1972
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICYANONITROBENZENE (3,4-)
RTECS NUMBER
: TI8576000
CHEMICAL NAME
: Phthalonitrile, 4-nitroCAS REGISTRY NUMBER
: 31643-49-9
LAST UPDATED
: 199703
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C8-H3-N3-O2
MOLECULAR WEIGHT
: 173.14
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 1,2-Benzenedicarbonitrile, 4-nitro* 3,4-Dicyanonitrobenzene
* 4-Nitro-1,2-benzenedicarbonitrile
* 4-Nitrophthalonitrile
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 850 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(9),92,1987
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(9),92,1987
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2550 mg/kg/30D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Kidney, Ureter, Bladder - proteinuria
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(9),92,1987
(V/O
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DICYCLOHEXANO-18-CROWN-6 (CIS-)
RTECS NUMBER
: HP5385000
CHEMICAL NAME
: Dibenzo(b,k)(1,4,7,10,13,16)hexaoxacyclooctadecin,
eicosahydroCAS REGISTRY NUMBER
: 16069-36-6
BEILSTEIN REFERENCE NO. : 1130529
LAST UPDATED
: 199710
DATA ITEMS CITED
: 13
MOLECULAR FORMULA
: C20-H36-O6
MOLECULAR WEIGHT
: 372.56
COMPOUND DESCRIPTOR
: Drug
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Dicyclohexano-18-crown-6
* D2-06
* Dicyclohexyl-18-crown-6
* 2,5,8,15,18,21-Hexaoxatricyclo(20.4.0.0(sup 9,14))hexacosane
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,451,1985
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg
REACTION SEVERITY
: Moderate
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,451,1985
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 176 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,451,1985
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and
Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
Volume(issue)/page/year:
11,408,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 55 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,451,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 192 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(11),72,1987
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 53 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 8,451,1985
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 130 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571202
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4575 mg/kg/61D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(11),72,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 910 mg/kg/26W-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(11),72,1987
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 105 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 52(11),72,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICYCLOHEXYL PHTHALATE
RTECS NUMBER
: TI0889000
CHEMICAL NAME
: Phthalic acid, dicyclohexyl ester
CAS REGISTRY NUMBER
: 84-61-7
BEILSTEIN REFERENCE NO. : 1889288
REFERENCE
: 4-09-00-03189 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C20-H26-O4
MOLECULAR WEIGHT
: 330.46
WISWESSER LINE NOTATION : L6TJ AOVR BVO- AL6TJ
SYNONYMS/TRADE NAMES :
* 1,2-Benzenedicarboxylic acid, dicyclohexyl ester
* Dicyclohexyl phthalate
* Ergoplast.fdc
* HF 191
* KP 201
* Unimoll 66
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 30 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 3,61,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10500 mg/kg/7D-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
51,217,1982
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993
OEL-SWEDEN: NGV 3 mg/m3, KTV 5 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1160
No. of Facilities: 1479 (estimated)
No. of Industries: 26
No. of Occupations: 27
No. of Employees: 13714 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1160
No. of Facilities: 560 (estimated)
No. of Industries: 5
No. of Occupations: 6
No. of Employees: 3565 (estimated)
No. of Female Employees: 967 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICYCLOHEXYLAMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
HY4025000
Dicyclohexylamine
101-83-7
0605923
4-12-00-00022 (Beilstein Handbook Reference)
199710
18
C12-H23-N
181.36
L6TJ AM- AL6TJ
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* N-Cyclohexylcyclohexanamine
* DCHA
* Dicha
* N,N-Diclohexylamine
* Dicyklohexylamin
* Dodecahydrodiphenylamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,468,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
Standard Draize test
Administration into the eye
Rodent - rabbit
750 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,468,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 373 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,468,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,468,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 4,659,1958
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
IECHAD Industrial and Engineering Chemistry. (Washington, DC)
1923-70. For publisher information, see CHMTBL.
Volume(issue)/page/year:
29,1247,1937
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
V.15-62,
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 40 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 4,659,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2404 mg/kg/48W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 4,659,1958
** MUTATION DATA **
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 200 ug/L
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
9,188,1971
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 22,55,1980
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 22,55,1980
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979-
Volume(issue)/page/year:
7,178,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1151
No. of Facilities: 60 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 368 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1151
No. of Facilities: 40 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 3412 (estimated)
No. of Female Employees: 169 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9219;8EHQ-0892-9270
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DICYCLOHEXYLCARBODIIMIDE
RTECS NUMBER
: FF2160000
CHEMICAL NAME
: Carbodiimide, dicyclohexylCAS REGISTRY NUMBER
: 538-75-0
BEILSTEIN REFERENCE NO. : 0610662
REFERENCE
: 4-12-00-00072 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C13-H22-N2
MOLECULAR WEIGHT
: 206.37
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Bis(cyclohexyl)carbodiimide
* Cyclohexaamine, N,N'-methanetetraylbis* DCC
* DCCD
* DCCI
* Dicyclohexylcarbodiimide
* N,N'-Dicyclohexylcarbodiimide
* 1,3-Dicyclohexylcarbodiimide
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4836
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; on test (prechronic studies), May 1999
NTP Carcinogenesis studies; test completed (peer review), May 1999
DICYCLOPENTADIENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
PC1050000
4,7-Methanoindene, 3a,4,7,7a-tetrahydro77-73-6
1904092
2-05-00-00391 (Beilstein Handbook Reference)
199907
41
C10-H12
132.22
L C555 A DU IUTJ
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bicyclopentadiene
* Biscyclopentadiene
* 1,3-Cyclopentadiene, dimer
* Dicyklopentadien
* Dicyclopentadiene
* Dimer cyklopentadienu
* 3a,4,7,7a-Tetrahydro-4,7-methanoindene
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
Open irritation test
Administration onto the skin
Rodent - rabbit
9300 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,50,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 353 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
20,552,1971
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/4H
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
27,1,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology,
University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
40QBA3 "Proceedings of the International Congress on Toxicology,
Toxicology
as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A.
Duncan,
eds., New York, Academic Press, Inc., 1978 Volume(issue)/page/year:
-,448,1978
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 145 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
20,552,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology,
University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 773 ppm/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
20,552,1971
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 771 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.120,552,1971
1959-
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5080 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
20,552,1971
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 770 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
20,552,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cattle
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Gastrointestinal - changes in structure or function of salivary glands
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A093-673
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A087-257
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - domestic
DOSE/DURATION
: 1010 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A087-257
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 182 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(2),77,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1120 mg/kg/28D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(108),71,1990
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 ppm/6H/2W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
27,1,1970
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 35 ppm/7H/18W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.120,552,1971
1959-
Volume(issue)/page/year:
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 ppm/6H/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in sodium
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,
POB 2155, Princeton, NJ 08540) V.11985- Volume(issue)/page/year:
8,353,1992
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 mg/m3/4H/26W-I
TOXIC EFFECTS :
Behavioral - excitement
Vascular - BP elevation not characterized in autonomic section
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 9(12),13,1965
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 72 ppm/7H/2W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
20,552,1971
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 714 ppm/6H/11D-F
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536197
*** REVIEWS ***
ACGIH TLV-TWA 27 mg/m3 (5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 ppm (30 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 0.5 ppm (3 mg/m3), JAN1999
OEL-BELGIUM:TWA 5 ppm (27 mg/m3) JAN 1993
OEL-FINLAND:TWA 5 ppm (30 mg/m3);STEL 10 ppm (54 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 5 ppm (30 mg/m3) JAN 1993
OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (30 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 5 ppm (30 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DICYCLOPENTADIENE-air:10H TWA 5 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83439
No. of Facilities: 2292 (estimated)
No. of Industries: 24
No. of Occupations: 38
No. of Employees: 41365 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83439
No. of Facilities: 252 (estimated)
No. of Industries: 4
No. of Occupations: 8
No. of Employees: 6248 (estimated)
No. of Female Employees: 442 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIELDRIN
RTECS NUMBER
CHEMICAL NAME
: IO1750000
: 1,4:5,8-Dimethanonaphthalene,
1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8aoctahydro, endo,exoCAS REGISTRY NUMBER
: 60-57-1
OTHER CAS REGISTRY NOS. : 3039-00-7
LAST UPDATED
: 199907
DATA ITEMS CITED
: 129
MOLECULAR FORMULA
: C12-H8-Cl6-O
MOLECULAR WEIGHT
: 380.90
WISWESSER LINE NOTATION : T E3 D5 C555 A D- FO KUTJ AG AG BG JG KG LG
EXO
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Aldrin epoxide
* Alvit 55
* Compound 497
* Dieldrex
* Dieldrin
* Dieldrine
* exo-Dieldrin
* Dielmoth
* Dorytox
* ENT 16,225
* HEOD
* Hexachloroepoxyoctahydro-endo,exo-dimethanonaphthalene
* Illoxol
* Insecticide No. 497
* Insectlack
* Kombi-Albertan
* Latka 497
* Moth Snub D
* NCI-C00124
* Octalox
* Panoram D-31
* Red Shield
* RCRA waste number P037
* SD 3417
* Termitox
ENDO
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,215,1969
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human
DOSE/DURATION
: 28 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
22,115,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 38300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 3,402,1955
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 13 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rat
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 18,161,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 85,437,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 49 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
21,269,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,13,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 26 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,288,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,408,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
60,289,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information
Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year:
6,198,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 3,64,1951
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
32ZDAL "Aldrin Dieldrin Endrin and Telodrin: An Epidemiological and
Toxicological Study of Long-Term Occupational Exposure," Jager, K.W., New
York, Elsevier Science Pub. Co., 1970 Volume(issue)/page/year: -,79,1970
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - other changes
REFERENCE :
CVETAA Communicationes Veterinariae. (Bogor, Indonesia) V.1-9, 1957-65.
Discontinued. Volume(issue)/page/year: 2,71,1958
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 80 mg/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 8(4),30,1964
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - withdrawal
Gastrointestinal - nausea or vomiting
REFERENCE :
CVETAA Communicationes Veterinariae. (Bogor, Indonesia) V.1-9, 1957-65.
Discontinued. Volume(issue)/page/year: 2,71,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,377,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPEADM Special Publication of the Entomological Society of America.
(4603
Calvert Rd., College Park, MD 20740) Volume(issue)/page/year:
78-1,13,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,73,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - pig
DOSE/DURATION
: 38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 7,159,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 49 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,377,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 9,11,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 23700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing
Materials, 1916 Race St., Philadelphia, PA 19103) No.11911Volume(issue)/page/year: (680),157,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
32ZDAL "Aldrin Dieldrin Endrin and Telodrin: An Epidemiological and
Toxicological Study of Long-Term Occupational Exposure," Jager, K.W., New
York, Elsevier Science Pub. Co., 1970 Volume(issue)/page/year: -,79,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Behavioral - excitement
Behavioral - food intake (animal)
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America,
4603
Calvert Rd., College Park, MD 20740) V.11908Volume(issue)/page/year:
44,1013,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 10780 ug/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Behavioral - irritability
REFERENCE :
ETOCDK Environmental Toxicology and Chemistry. (Pergamon Press Inc.,
Maxwell House, Fairview Park, Elmsford, NY 10523) V.11982Volume(issue)/page/year: 1,157,1982
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Bird - duck
DOSE/DURATION
: 381 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
20,57,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 94 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB288-416
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,
Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,63,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 13300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing
Materials, 1916 Race St., Philadelphia, PA 19103) No.11911Volume(issue)/page/year: (680),157,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 75 mg/kg/15D-C
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
11,131,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 88 mg/kg/88D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 25,461,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 140 mg/kg/8W-I
TOXIC EFFECTS :
Liver - other changes
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
37,29,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 109 mg/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 3,402,1955
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 410 mg/kg/39W-C
TOXIC EFFECTS :
Liver - other changes
Related to Chronic Data - death
REFERENCE :
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60.
For
publisher information, see APLMAS. Volume(issue)/page/year: 64,614,1957
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 75600 ug/kg/18W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - Plasma proteins not involving
coagulation
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 39,79,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 840 ug/kg/2W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 39,79,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 27200 ug/kg/68W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11953- Volume(issue)/page/year: 3,402,1955
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 51 mg/kg/17D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - convulsions or effect on seizure threshold
Related to Chronic Data - death
REFERENCE :
CVETAA Communicationes Veterinariae. (Bogor, Indonesia) V.1-9, 1957-65.
Discontinued. Volume(issue)/page/year: 2,71,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 751 ug/kg/13W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Immunological Including Allergic - decrease in humoral immune response
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 10,42,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 14 mg/kg/14D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St.,
Champaign, IL 61820) V.11921- Volume(issue)/page/year: 53,54,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 239 mg/kg/30D-C
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Skin and Appendages - hair
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB288-416
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - domestic
DOSE/DURATION
: 68 mg/kg/8W-C
TOXIC EFFECTS :
Autonomic Nervous System - sympathomimetic
Liver - changes in liver weight
Biochemical - Neurotransmitters or modulators (putative) - dopamine at
other
sites
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
53,75,1980
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology.
(London, UK)
V.1-19, 1963-81.
For
publisher information, see FCTOD7.
Volume(issue)/page/year: 2,551,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 546 mg/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 2,197,1979
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 11 gm/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,415,1973
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 610 mg/kg/73W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,433,1973
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 714 mg/kg/85W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21202) V.11952- Volume(issue)/page/year:
44,392,1981
TYPE OF TEST
ROUTE OF EXPOSURE
: TD - Toxic dose (other than lowest)
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,941,1982
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4550 mg/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
41,3615,1981
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 14 ug/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11971- Volume(issue)/page/year:
13,20,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 30600 ug/kg
SEX/DURATION
: female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.11946- Volume(issue)/page/year: 25,907,1970
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
15 mg/kg
female 9 day(s) after conception
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 9,11,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2250 ug/kg
SEX/DURATION
: female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 16,57,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 12500 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,317,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4500 ug/kg
SEX/DURATION
: female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 16,57,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 6250 ug/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 9,26,1975
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Mammal - dog
219 mg/kg
female 44 week(s) pre-mating
female 1-8 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
REFERENCE :
JAVMA4 Journal of the American Veterinary Medical Association. (American
Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)
V.481915- Volume(issue)/page/year: 123,28,1953
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 30 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 9,11,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 30 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 9,11,1974
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Mutation in microorganisms
: Bacteria - Salmonella typhimurium
: 1 mg/L
REFERENCE :
JOHEA8 Journal of Heredity.
Washington, DC 20006) V.5-
(American Genetic Assoc., 818 18th St., NW,
1914- Volume(issue)/page/year: 68,184,1977
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
42,161,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 mg/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
45,101,1980
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 400 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
92,427,1982
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 15 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
40,1157,1980
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 10 mg/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
45,101,1980
TYPE OF TEST
: Specific locus test
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
17,196,1991
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,305,1977
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 1 ppm/4H
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
3,10,1979
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1200 ug/kg
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
2,80,1966
(Plenum Pub.
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 40 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 10 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
19,369,1977
TYPE OF TEST
TEST SYSTEM
: Mutation test systems - not otherwise specified
: Mammal - species unspecified Fibroblast
DOSE/DURATION
: 50 mg/L
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 15,581,1986
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Bird - duck Lymphocyte
DOSE/DURATION
: 100 ppm
REFERENCE :
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed.,
New
York, Plenum Pub. Corp., 1976 Volume(issue)/page/year: -,555,1976
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.25 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 5,125,1974
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 5,125,1974
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,196,1987
TOXICOLOGY REVIEW
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 7,243,1974
TOXICOLOGY REVIEW
JSIRAC Journal of Scientific and Industrial Research. (Pub. &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110012, India) V.1-4,
1942-45;
V.22-
1963-
Volume(issue)/page/year: 34,462,1975
TOXICOLOGY REVIEW
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.)
V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
56,107,1975
V.1-
1962-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
ECMAAI Economie et Medecine Animales. (Paris, France)
Discontinued. Volume(issue)/page/year: 14,141,1973
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine.
V.1-17, 1960-76.
(New York Academy
of
Medicine, 2 E. 103rd St., New York, NY 10029)
Volume(issue)/page/year: 54,413,1978
Ser 2: V.1-
1925-
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971
Volume(issue)/page/year:
5,250,1970
TOXICOLOGY REVIEW
26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth
&
Seventh Inter-American Conferences on Toxicology and Occupational
Medicine,
Miami, FL," Miami, FL, J.L. Halos, 1968-70 Volume(issue)/page/year:
6,149,1968/1970
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978
TOXICOLOGY REVIEW
EESADV Ecotoxicology and Environmental Safety.
(Academic Press, Inc., 1
E.
First St., Duluth, MN 55802)
1,89,1977
V.1-
1977-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
10,613,1967
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.25 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,84,1971
OSHA PEL (Gen Indu):8H TWA 0.25 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.25 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.25 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.25 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.25 mg/m3;Skin JAN 1993
OEL-AUSTRIA: MAK 0.25 mg/m3, Skin, JAN1999
OEL-AUSTRIA:TWA 0.25 mg/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.25 mg/m3;Skin JAN 1993
OEL-DENMARK: 0.25 mg/m3, Skin, JAN1999
OEL-FINLAND:TWA 0.25 mg/m3;STEL 0.75 mg/m3;Skin;Carcinogen JAN 1993
OEL-GERMANY:TWA 0.25 mg/m3;Skin JAN 1993
OEL-INDIA:TWA 0.25 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.25 mg/m3;Skin JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg/m3, STEL 1.5 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 0.25 mg/m3;Skin JAN 1993
OEL-RUSSIA:STEL 0.01 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.25 mg/m3;Skin JAN 1993
OEL-THAILAND:TWA 0.25 mg/m3 JAN 1993
OEL-TURKEY:TWA 0.25 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.25 mg/m3;STEL 0.75 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIELDRIN-air:CA TWA 0.25 mg/m3 (Sk) (0.15 mg/m3 LOQ)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2830
No. of Facilities: 56 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 760 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/89/214514/AS
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated
assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-21,1978
NCI Carcinogenesis Bioassay (feed);no evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-22,1978
NCI Carcinogenesis Bioassay (feed);no evidence:rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-21,1978
DIEPOXYOCTANE (1,2,7,8-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
RG9450000
Octane, 1,2:7,8-diepoxy2426-07-5
0104873
5-19-01-00229 (Beilstein Handbook Reference)
199710
15
C8-H14-O2
142.22
T3OTJ B4- BT3OTJ
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2,2'-(1,4-Butanediyl)bisoxirane
* 1,2:7,8-Diepoxyoctane
* 1,2-Epoxy-7,8-epoxyoctane
* Oxirane, 2,2'-(1,4-butanediyl)bis*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 ug/24H
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1070 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 320 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6600 mg/kg/55W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
39,1217,1967
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 433 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
203,39,1988
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 990 ug/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 72,5135,1975
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
231,205,1990
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Klebsiella pneumoniae
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,269,1981
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 6900 umol/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
222,359,1989
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Mold - Neurospora crassa
DOSE/DURATION
: 75 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
32,1890,1972
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 12500 nmol/L
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(2),587,1979
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 3900 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
249,55,1991
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 12500 nmol/L
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(2),587,1979
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; Histidine
reversion-Ames test
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHANOLAMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
KL2975000
Ethanol, 2,2'-iminodi111-42-2
0605315
4-04-00-01514 (Beilstein Handbook Reference)
199907
50
C4-H11-N-O2
105.16
Q2M2Q
Tumorigen
Drug
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bis(2-hydroxyethyl)amine
* DEA
* Diaethanolamin
* Diethanolamin
* Diethanolamine
* Diethylamine, 2,2'-dihydroxy* Diethylolamine
* 2,2'-Dihydroxydiethylamine
* Di(2-hydroxyethyl)amine
* Diolamine
* 2-(2-Hydroxyethylamino)ethanol
* 2,2'-Iminobisethanol
* 2,2'-Iminodiethanol
* NCI-C55174
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/29/1971
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,685,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5500 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 750 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,685,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 620 uL/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - tremor
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516797
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVSSAV Environmental Space Science. English Translation of Kosmicheskaya
Biologiya Meditsina. 1967-70. Volume(issue)/page/year: 2,289,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVSSAV Environmental Space Science. English Translation of Kosmicheskaya
Biologiya Meditsina. 1967-70. Volume(issue)/page/year: 2,289,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 778 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVSSAV Environmental Space Science. English Translation of Kosmicheskaya
Biologiya Meditsina. 1967-70. Volume(issue)/page/year: 2,289,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVSSAV Environmental Space Science. English Translation of Kosmicheskaya
Biologiya Meditsina. 1967-70. Volume(issue)/page/year: 2,289,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 29(11),25,1964
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516742
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVSSAV Environmental Space Science. English Translation of Kosmicheskaya
Biologiya Meditsina. 1967-70. Volume(issue)/page/year: 2,289,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Administration onto the skin
: Rodent - rabbit
DOSE/DURATION
: 7640 uL/kg
TOXIC EFFECTS :
Behavioral - ataxia
Musculoskeletal - other changes
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516797
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,197,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 11900 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516742
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520710
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 52 gm/kg/14D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - normocytic anemia
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206-
Volume(issue)/page/year: NIH-92-3343
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8827 mg/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Blood - normocytic anemia
Related to Chronic Data - changes in testicular weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3343
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 49 gm/kg/7W-C
TOXIC EFFECTS :
Liver - other changes
Blood - normocytic anemia
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
17,308,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1008 mg/kg/16D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - normocytic anemia
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3343
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8125 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - normocytic anemia
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3343
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
30366 mg/kg/14D-C
Liver - changes in liver weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3343
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 38402 mg/kg/13W-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Kidney, Ureter, Bladder - changes in bladder weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3343
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 30 gm/kg/16D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Skin and Appendages - dermatitis, other (after systemic exposure)
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3343
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 40950 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3343
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 18382 mg/kg
SEX/DURATION
: male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3343
*** REVIEWS ***
ACGIH TLV-TWA 2 mg/m3 (0.46 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 3 ppm (15 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 3 ppm (13 mg/m3), JAN1999
OEL-BELGIUM:TWA 3 ppm (13 mg/m3) JAN 1993
OEL-DENMARK: TWA 3 ppm (15 mg/m3), JAN1999
OEL-THE NETHERLANDS:TWA 3 ppm (15 mg/m3) JAN 1993
OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 3 ppm (13 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 3 ppm (15 mg/m3) JAN 1993
OEL-SWEDEN: TWA 3 ppm (15 mg/m3), STEL 6 ppm (30 mg/m3), Skin, JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIETHANOLAMINE-air:10H TWA 3 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0517
No. of Facilities: 315 (estimated)
No. of Industries: 3
No. of Occupations: 2
No. of Employees: 857 (estimated)
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24615
No.
No.
No.
No.
of
of
of
of
Facilities: 18443 (estimated)
Industries: 147
Occupations: 118
Employees: 186455 (estimated)
NOES - National Occupational
NOES Hazard Code - 24615
No. of Facilities: 46466
No. of Industries: 249
No. of Occupations: 171
No. of Employees: 828471
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
218923 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8736;8EHQ-0293-8746
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Aminoethanol compounds II, 3509
NTP Toxicity studies, RPT# TOX-20, May 1999
NTP Carcinogenesis studies; test completed (camera copy in progress), May
1999
DIETHOXYDIMETHYLSILANE
RTECS NUMBER
: VV3590000
CHEMICAL NAME
: Silane, diethoxydimethylCAS REGISTRY NUMBER
: 78-62-6
BEILSTEIN REFERENCE NO. : 1736110
REFERENCE
: 4-04-00-04101 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C6-H16-O2-Si
MOLECULAR WEIGHT
: 148.31
WISWESSER LINE NOTATION : 2O-SI-1&1&O2
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Diethoxydimethylsilane
* Dimethyl-diethoxysilan
* Dimethylsilicondiethoxide
* KBE 22
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1226,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 83 mg
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,332,1948
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1226,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1226,1986
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 gm/m3/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1226,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4000 ppm/7H/10D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,332,1948
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7420
No. of Facilities: 114 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 518 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHOXYETHANE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
KI1225000
Ethane, 1,2-diethoxy629-14-1
1732917
4-01-00-02379 (Beilstein Handbook Reference)
199710
11
C6-H14-O2
118.20
2O2O2
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,2-Diethoxyethane
* Diethyl cellosolve
* Diethylether ethylenglykolu
* Ethyl glyme
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
Standard Draize test
Administration into the eye
Rodent - rabbit
100 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4390 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,343,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2440 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 23640 mg/kg
SEX/DURATION
: female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402)
Volume(issue)/page/year: 57,141,1984
No.1-
1972-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 23640 mg/kg
SEX/DURATION
: female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
7,29,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5000 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB88-134093
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 10 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB88-134093
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rabbit
1400 mg/kg
SEX/DURATION
: female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 19,15,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHOXYMETHANE
RTECS NUMBER
: PA8500000
CHEMICAL NAME
: Methane, diethoxyCAS REGISTRY NUMBER
: 462-95-3
BEILSTEIN REFERENCE NO. : 1697253
REFERENCE
: 4-01-00-03027 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C5-H12-O2
MOLECULAR WEIGHT
: 104.17
WISWESSER LINE NOTATION : 2O1O2
SYNONYMS/TRADE NAMES :
* 1,1-Diethoxymethane
* Diethylformal
* 3,5-Dioxaheptene
* Ethane, 1,1'-(methylenebis(oxy))bis* Ethoxymethyl ethyl ether
* Ethylal
* Formaldehyde diethyl acetal
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2604 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-
1903/04Volume(issue)/page/year: 29,730,1932
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84039
No. of Facilities: 5 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 20 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYL CARBONATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
FF9800000
Carbonic acid, diethyl ester
105-58-8
199701
10
C5-H10-O3
118.15
2OVO2
Tumorigen
Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* DEC
* Diatol
* Diethylester kyseliny uhlicite
* Diethylkarbonat
* Ethoxyformic anhydride
* Ethyl carbonate
* Eufin
* NCI-C60899
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept.
of
National Health and Welfare, Food and Drug Divisions, 35 John St.,
Ottawa,
Ont., Canada)
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
2,168,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 456 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
2,168,1959
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 496 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
27,1696,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 496 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
27,1696,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 1004 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
27,1696,1967
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1089
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 83 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1089
No. of Facilities: 415 (estimated)
No. of Industries: 3
No. of Occupations: 8
No. of Employees: 6967 (estimated)
No. of Female Employees: 1022 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYL CHLOROPHOSPHATE
RTECS NUMBER
: TD1400000
CHEMICAL NAME
: Phosphorochloridic acid, diethyl ester
CAS REGISTRY NUMBER
: 814-49-3
BEILSTEIN REFERENCE NO. : 0471433
REFERENCE
: 4-01-00-01345 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 12
MOLECULAR FORMULA
: C4-H10-Cl-O3-P
MOLECULAR WEIGHT
: 172.56
WISWESSER LINE NOTATION : 2OPO&GO2
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Chlorophosphoric acid, diethyl ester
* Diethoxyphosphorus oxychloride
* Diethylchlorfosfat
* Diethyl chlorophosphate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1142,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 11 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570912
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570912
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570912
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 8 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
*** REVIEWS ***
TOXICOLOGY REVIEW
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office
Dept.
223, POB 57136, West End Stn., Washington, DC 20037) V.11924Volume(issue)/page/year: 48,225,1951
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4014
No. of Facilities: 24 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 47 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4014
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 919 (estimated)
No. of Female Employees: 306 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHYL CHLOROTHIOPHOSPHATE
RTECS NUMBER
: TD1780000
CHEMICAL NAME
: Phosphorochloridothioic acid, O,O-diethyl ester
CAS REGISTRY NUMBER
: 2524-04-1
BEILSTEIN REFERENCE NO. : 0471434
REFERENCE
: 4-01-00-01352 (Beilstein Handbook Reference)
LAST UPDATED
: 199812
DATA ITEMS CITED
: 13
MOLECULAR FORMULA
: C4-H10-Cl-O2-P-S
MOLECULAR WEIGHT
: 188.62
WISWESSER LINE NOTATION : 2OPS&GO2
SYNONYMS/TRADE NAMES :
* O,O-Diethylphosphorochloridothioate
* Diethylchlorthiofosfat
* Diethylchlorothiophosphate
* Ethyl PCT
* Phosphonothioic acid, chloro-, O,O-diethyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1340 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Gastrointestinal - changes in structure or function of salivary glands
Blood - hemorrhage
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(10-12),334,1968
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1172,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,51,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 725 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,51,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 56(5),6,1991
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rabbit
(V/O
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Gastrointestinal - changes in structure or function of salivary glands
Blood - hemorrhage
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(10-12),334,1968
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
Blood - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536769
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 810 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Gastrointestinal - changes in structure or function of salivary glands
Blood - hemorrhage
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(10-12),334,1968
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 mg/m3/24H/17W-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 56(5),6,1991
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4068
No. of Facilities: 30 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 1088 (estimated)
No. of Female Employees: 187 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHYL ETHER
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
KI5775000
Ethane, 1,1'-oxybis60-29-7
199907
60
C4-H10-O
74.14
2O2
Tumorigen
Drug
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aether
* Anaesthetic ether
* Anesthesia ether
* Anesthetic ether
* Diaethylaether
* Diethyl ether
* Diethyl oxide
* Dwuetylowy eter
* Etere etilico
* Ether
* Ether ethylique
* Ethoxyethane
* Ethyl ether
* Oxyde d'ethyle
* RCRA waste number U117
* Solvent ether
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Human
DOSE/DURATION
: 100 ppm
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,282,1943
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 360 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/5/1973
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Moderate
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 35,729,1976
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 50 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
HIFUAG Hifu. Skin. (Nippon Hifuka Gakkai Osaka Chihokai, c/o Osaka
Daigaku
Igakubu, 1-1-50 Fukushima, Fukushima-ku, Osaka 553, Japan) V.1- 1959Volume(issue)/page/year: 22,373,1980
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Human
200 ppm
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,282,1943
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,699,1971
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 32000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 31000 ppm/30M
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JIDOAA Experimental Animals. Jikken Dobutso Iho. (Nippon Jikken Dobutsu
Gakkai, c/o Keio Gijuku Daigaku Igakubu Jikken Dobutsu Senta, 35
Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.11952Volume(issue)/page/year: 34,379,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.11958Volume(issue)/page/year: 27,511,1984
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Subcutaneous
Rodent - mouse
8 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1295,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 996 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 67,566,1978
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 76000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1294,1935
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 106000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1294,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Biochemical - Enzyme
:
:
:
:
LDLo - Lowest published lethal dose
Intraperitoneal
Rodent - guinea pig
2 gm/kg
inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
35,21,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 24 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1295,1935
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1000 ppm/24H/5W-C
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
42,408,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 pph/24H/5W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
42,408,1975
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 35670 ug/well/16H
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
15,219,1976
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 2850 mg/L
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 5,1,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 1 pph
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
43,21,1975
*** REVIEWS ***
ACGIH TLV-STEL 1520 mg/m3 (500 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 1210 mg/m3 (400 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal No Adequate Data
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,93,1987
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 400 ppm (1200 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,106,1971
OSHA PEL (Gen Indu):8H TWA 400 ppm (1200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 400 ppm (1200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
Volume(issue)/page/year:
OSHA PEL (Shipyard):8H TWA 400 ppm (1200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 400 ppm (1200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 400 ppm (1200 mg/m3);STEL 500 ppm (1500 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 400 ppm (1200 mg/m3), JAN1999
OEL-AUSTRIA:TWA 400 ppm (1200 mg/m3) JAN 1993
OEL-BELGIUM:TWA 400 ppm (1210 mg/m3);STEL 500 ppm (1520 mg/m3) JAN 1993
OEL-DENMARK: TWA 400 ppm (1200 mg/m3), JAN1999
OEL-FINLAND:TWA 400 ppm (1200 mg/m3);STEL 500 ppm (1500 mg/m3) JAN 1993
OEL-JAPAN: OEL 400 ppm (1200 mg/m3), JAN1999
OEL-GERMANY:TWA 400 ppm (1200 mg/m3) JAN 1993
OEL-HUNGARY:TWA 300 mg/m3;STEL 600 mg/m3;Skin JAN 1993
OEL-POLAND: MAC(TWA) 300 mg/m3, MAC(STEL) 1500mg/m3, JAN1999
OEL-JAPAN:TWA 400 ppm (1200 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 400 ppm (1200 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 400 ppm (1200 mg/m3) JAN 1993
OEL-RUSSIA:TWA 400 ppm;STEL 300 mg/m3 JAN 1993
OEL-SWEDEN:TWA 400 ppm (1200 mg/m3);STEL 500 ppm (1500 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 400 ppm (1200 mg/m3);STEL 800 ppm JAN 1993
OEL-TURKEY:TWA 400 ppm (1200 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 400 ppm (1200 mg/m3);STEL 500 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 32590
No. of Facilities: 17282 (estimated)
No. of Industries: 112
No. of Occupations: 82
No. of Employees: 161572 (estimated)
NOES - National Occupational
NOES Hazard Code - 32590
No. of Facilities: 21212
No. of Industries: 104
No. of Occupations: 78
No. of Employees: 272746
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
35683 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-forward mutation; Sperm
morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Ethyl ether, 1610
DIETHYL ETHOXYMETHYLENEMALONATE
RTECS NUMBER
: OO1100000
CHEMICAL NAME
: Malonic acid, (ethoxymethylene)-, diethyl ester
CAS REGISTRY NUMBER
: 87-13-8
OTHER CAS REGISTRY NOS. : 69731-53-9
BEILSTEIN REFERENCE NO. : 0880058
REFERENCE
: 4-03-00-01192 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C10-H16-O5
MOLECULAR WEIGHT
: 216.26
WISWESSER LINE NOTATION : 2OVYVO2&U1O2
COMPOUND DESCRIPTOR
: Drug
Primary Irritant
SYNONYMS/TRADE NAMES :
*
*
*
*
*
Diethyl EMME
Diethyl (ethoxymethylene)malonate
Ethoxymethylenemalonic acid, ethyl ester
Propanedioic acid, (ethoxymethylene)-, diethyl ester
TL 1483
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,37,1990
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 925 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Gastrointestinal - other changes
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,37,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2227 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 60,1810,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LCLo - Lowest published lethal concentration
Inhalation
Rodent - mouse
44 mg/m3
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research
and Development, Progress Report. Volume(issue)/page/year: 30101,11,1945
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYL FUMARATE
RTECS NUMBER
: EM5950000
CHEMICAL NAME
: 2-Butenedioic acid, diethyl ester, (E)CAS REGISTRY NUMBER
: 623-91-6
BEILSTEIN REFERENCE NO. : 0775347
REFERENCE
: 4-02-00-02207 (Beilstein Handbook Reference)
LAST UPDATED
: 199812
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C8-H12-O4
MOLECULAR WEIGHT
: 172.20
WISWESSER LINE NOTATION : 2OV1U1VO2
SYNONYMS/TRADE NAMES :
* Diethylester kyseliny fumarove
* Diethyl fumarate
* Ethyl fumarate
* Fumaric acid, diethyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 gm/kg/2W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571509
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81805
No. of Facilities: 367 (estimated)
No. of Industries: 3
No. of Occupations: 11
No. of Employees: 1350 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHYL MALEATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
ON1225000
Maleic acid, diethyl ester
141-05-9
1100825
4-02-00-02207 (Beilstein Handbook Reference)
199806
11
C8-H12-O4
172.20
2OV1U1VO2
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* 2-Butenedioic acid (Z)-, diethyl ester
* Diethylester kyseliny maleinove
* Diethyl maleate
* Ethyl maleate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 530 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 10/29/1957
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 31,60,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,443,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3070 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
52,422,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 10/29/1957
** MUTATION DATA **
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 225 umol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
3,193,1988
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 8700 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,135,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHYL MALONATE
RTECS NUMBER
: OO0700000
CHEMICAL NAME
: Malonic acid, diethyl ester
CAS REGISTRY NUMBER
: 105-53-3
LAST UPDATED
: 199701
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C7-H12-O4
MOLECULAR WEIGHT
: 160.19
WISWESSER LINE NOTATION : 2OV1VO2
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Carbethoxyacetic ester
* Dicarbethoxymethane
* Diethyl malonate
* Diethyl propanedioate
* Ethyl malonate
* Malonic ester
* Methanedicarboxylic acid, diethyl ester
* Propanedioic acid, diethyl ester
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK)
For
V.1-19, 1963-81.
publisher information, see FCTOD7.
Volume(issue)/page/year: 14,745,1976
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14900 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6400 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,
Commerce
Way, Colchester, Essex CO2 8HP, UK) V.11906Volume(issue)/page/year:
34,1196,1940
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >16 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4574
No. of Facilities: 312 (estimated)
No. of Industries: 7
No. of Occupations: 9
No. of Employees: 6753 (estimated)
No. of Female Employees: 1766 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYL NICOTINAMIDE (N,N-)
RTECS NUMBER
: QS4375000
CHEMICAL NAME
: Nicotinamide, N,N-diethylCAS REGISTRY NUMBER
: 59-26-7
BEILSTEIN REFERENCE NO. : 0005743
REFERENCE
: 5-22-02-00084 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C10-H14-N2-O
MOLECULAR WEIGHT
: 178.26
WISWESSER LINE NOTATION : T6NJ CVN2&2
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Anacardone
* Anacordone
* Astrocar
* Canfodiamina
* Camphozone
* Carbamidal
* Cardamine
* Cardiagen
* Cardiamid
* Cardiamina
* Cardiamine
* Cardimon
* Coracon
* Coraethamide
* Coraethamidum
* Coralept
* Coramine
* Coravita
* Corazone
* Cordiamid
* Cordiamin
* Cordiamine
* Corditon
* Cordynil
* Corediol
* Corespin
* Corethamide
* Coretone
* Cormed
* Cormid
* Cormotyl
* Cornotone
* Corotonin
* Corovit
* Corvitan
* Corvitol
* Corvotone
* Corywas
* Danamine
* Diaethyl-nicotinamid
* Diethylamid kyseliny nikotinove
* Diethyl-nicotamide
* N,N-Diethylnicotinamide
* N,N-Diethyl-3-pyridinecarboxamide
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Dietilamide-carbopiridina
Dinacoryl
Dynacoryl
Dynamicarde
Elitone
Eucoran
Hansacor
Inicardio
Kardiamid
Kardonyl
Kordiamin
Leptamin
Mediamid
Niamine
Nicamide
Nicetamide
Nicethamide
Nicor
Nicordamin
Nicorine
Nicoryl
Nicotinic acid diethylamide
Nikardin
Niketamid
Nikethamide
Niketharol
Nikethyl
Niketilamid
Nikorin
Nikotin
Niquetamida
Nisetamide
Percoral
Procardine
Procorman
Pyricardyl
Pyridine-3-carboxydiethylamide
Pyridine-3-carboxylic acid diethylamide
Reformin
Rehormin
Salvacard
Salvacorin
Stellamine
Stiminol
Stimulin
Tonocor
Ventramine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - rat
272 mg/kg
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug
Toxicity.
(Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see
PESTD5. Volume(issue)/page/year: 4,132,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 240 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 62,19,1946
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 191 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed.,
Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,173,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 188 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - rigidity (including catalepsy)
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry.
(New
York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:
1,423,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 174 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
V.1-
1909/10-
Volume(issue)/page/year: 128,176,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale
Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.331894Volume(issue)/page/year:
111,293,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co.,
Steintorst 13, 4010 Basel, Switzerland) V.501920Volume(issue)/page/year: 85,305,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 288 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
53,2S,1957
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.11922- Volume(issue)/page/year:
12,1860,1933
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Intravenous
Rodent - rabbit
150 mg/kg
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 66,260,1939
V.1-
1909/10-
DIETHYL NITROPHENYL PHOSPHATE (P-)
RTECS NUMBER
: TC2275000
CHEMICAL NAME
: Phosphoric acid, diethyl p-nitrophenyl ester
CAS REGISTRY NUMBER
: 311-45-5
BEILSTEIN REFERENCE NO. : 1915526
REFERENCE
: 4-06-00-01327 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 35
MOLECULAR FORMULA
: C10-H14-N-O6-P
MOLECULAR WEIGHT
: 275.22
WISWESSER LINE NOTATION : WNR DOPO&O2&O2
COMPOUND DESCRIPTOR
: Agricultural Chemical
Drug
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Chinorta
* O,O'Diaethyl-p-nitrophenylphosphat
* Diaethyl-p-nitrophenylphosphorsaeureester
* Diethyl-p-nitrofenyl ester kyseliny fosforecne
* Diethyl p-nitrophenyl phosphate
* O,O-Diethyl O-p-nitrophenyl phosphate
* Diethyl paraoxon
* O,O-Diethyl phosphoric acid O-p-nitrophenyl ester
* O,O-Dietyl-O-p-nitrofenylfosfat
* E 600
* ENT 16,087
* Ester 25
* Ethyl p-nitrophenyl ethylphosphate
* Ethyl paraoxon
* Eticol
* Fosfakol
* HC 2072
* Mintaco
* Mintacol
* Miotisal
* Miotisal A
* p-Nitrophenyl diethylphosphate
* Oxyparathion
* Paraoxon
* Paraoxone
* Paroxan
* Pestox 101
* Phenol, p-nitro-, ester with diethyl phosphate
* Phosphacol
* Phosphonothioic acid, diethylparanitrophenyl ester
*
*
*
*
Phosphoric acid diethyl 4-nitrophenyl ester
RCRA waste number P041
Soluglacit
TS 219
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 14 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31,
1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
25,329,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
16,1183,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 716 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11971- Volume(issue)/page/year:
26,202,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 426 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 27,1983,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 240 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
REFERENCE :
CJBPAZ Canadian Journal of Biochemistry and Physiology. (Ottawa, Ont.,
Canada) V.32-41, 1954-63. For publisher information, see CJBIAE.
Volume(issue)/page/year: 34,197,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 446 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
22,317,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 760 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HPFSDS HHS Publication (FDA. United States). (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) 1980Volume(issue)/page/year: FDA-80-1076,212,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 330 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 35,494,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 270 ug/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 34,603,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 520 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,684,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 710 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 237,211,1959
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information
Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year:
6,388,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 560 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.11967- Volume(issue)/page/year: 3,508,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Mammal - cat
700 ug/kg
Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
SFTIAE Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. (POB
1136, Stockholm 111 81, Sweden) V.11897- Volume(issue)/page/year:
57,261,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
SFTIAE Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. (POB
1136, Stockholm 111 81, Sweden) V.11897- Volume(issue)/page/year:
57,261,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3310 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABMHAM Archives Belges de Medecine Sociale, Hygiene, Medecine du Trevail
et
Medecine Legale. (Quartier Esplanade no.6, 1010 Brussels, Belgium) V.41946- Volume(issue)/page/year: (Suppl),226,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 230 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,113,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 300 ug/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
SFTIAE Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. (POB
1136, Stockholm 111 81, Sweden) V.11897- Volume(issue)/page/year:
57,261,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 300 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 53,512,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 500 ug/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
SFTIAE Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. (POB
1136, Stockholm 111 81, Sweden) V.11897- Volume(issue)/page/year:
57,261,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
16,1183,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 303 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11971- Volume(issue)/page/year:
26,202,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 175 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 23,103,1988
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Amphibian - frog
2587 ug/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11971- Volume(issue)/page/year:
26,202,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
SFTIAE Svensk Farmaceutisk Tidskrift. Swedish Journal of Pharmacy. (POB
1136, Stockholm 111 81, Sweden) V.11897- Volume(issue)/page/year:
57,261,1953
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 ug/kg/20D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
136,20,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1300 ug/kg/13D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 11,343,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6 mg/kg/48D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Related to Chronic Data - death
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
4,335,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 9430 ug/kg/90D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 72,117,1992
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Schizosaccharomyces pombe
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
117,139,1983
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 umol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 8,939,1981
*** REVIEWS ***
TOXICOLOGY REVIEW
RREVAH Residue Reviews.
(Springer-Verlag New York, Inc., Service Center,
44
Hartz Way, Secaucus, NJ 07094)
46,1,1973
V.1-
1962-
Volume(issue)/page/year:
*** STATUS IN U.S. ***
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHYL OXALATE
RTECS NUMBER
CHEMICAL NAME
: RO2800000
: Oxalic acid, diethyl ester
CAS REGISTRY NUMBER
: 95-92-1
BEILSTEIN REFERENCE NO. : 0606350
REFERENCE
: 4-02-00-01848 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C6-H10-O4
MOLECULAR WEIGHT
: 146.16
WISWESSER LINE NOTATION : 2OVVO2
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Diethylester kyseliny stavelove
* Diethyl ethanedioate
* Diethyl oxalate
* Ethanedioic acid, diethyl ester
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,373,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - antipsychotic
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(5),87,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5432
No. of Facilities: 96 (estimated)
No. of Industries: 2
No. of Occupations: 17
No. of Employees: 1483 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
(V/O
DIETHYL PHOSPHATE
RTECS NUMBER
: TC0665000
CHEMICAL NAME
: Phosphoric acid, diethyl ester
CAS REGISTRY NUMBER
: 598-02-7
BEILSTEIN REFERENCE NO. : 1704113
REFERENCE
: 4-01-00-01339 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C4-H11-O4-P
MOLECULAR WEIGHT
: 154.12
SYNONYMS/TRADE NAMES :
* Diethyl acid phosphate
* Diethyl hydrogen phosphate
* O,O-Diethyl hydrogen phosphate
* Diethyl phosphate
* Diethyl phosphoric acid
* Ethyl phosphate, di*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,37,1953
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYL PHOSPHITE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
:
:
:
:
:
:
:
:
:
:
TG7875000
Phosphorous acid, diethyl ester
762-04-9
0605759
4-01-00-01329 (Beilstein Handbook Reference)
199710
7
C4-H11-O3-P
138.12
2OPQO2
SYNONYMS/TRADE NAMES :
* Diethylfosfit
* Diethyl hydrogen phosphite
* Diethyl phosphite
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229)
Volume(issue)/page/year: #OPB-3,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2020 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
30,470,1969
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82805
No. of Facilities: 41 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 352 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82805
No. of Facilities: 84 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 505 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHYL PYROCARBONATE
RTECS NUMBER
: LQ9350000
CHEMICAL NAME
: Formic acid, oxydi-, diethyl ester
CAS REGISTRY NUMBER
: 1609-47-8
BEILSTEIN REFERENCE NO. : 0637031
REFERENCE
: 4-03-00-00018 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 11
MOLECULAR FORMULA
: C6-H10-O5
MOLECULAR WEIGHT
: 162.16
WISWESSER LINE NOTATION : 2OVOVO2
SYNONYMS/TRADE NAMES :
* Baycovin
* Dicarbonic acid diethyl ester
* DEPC
* Diethyl dicarbonate
* Diethylester kyseliny diuhlicite
* Diethyl ester of pyrocarbonic acid
* Diethyl oxydiformate
* Diethyl pyrocarbonate
* Diethyl pyrocarbonic acid
* Diethylpyrokarbonat
* DKD
* Ethyl pyrocarbonate
* Oxydiformic acid diethyl ester
* Piref
* Pyrocarbonate d'ethyle
* Pyrocarbonic acid, diethyl ester
* Pyrokohlensaeure diaethyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZLUFAR Zeitschrift fuer Lebensmittel-Untersuchung und-Forschung.
(Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.)
V.861943- Volume(issue)/page/year: 114,292,1961
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1558 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 ppm/1H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,52,1974
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 ppm/1H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 10 ppm/1H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 51A,67,1972
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYL SUCCINATE
RTECS NUMBER
: WM7400000
CHEMICAL NAME
: Succinic acid, diethyl ester
CAS REGISTRY NUMBER
: 123-25-1
BEILSTEIN REFERENCE NO. : 0907645
REFERENCE
: 4-02-00-01914 (Beilstein Handbook Reference)
LAST UPDATED
: 199806
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C8-H14-O4
MOLECULAR WEIGHT
: 174.22
WISWESSER LINE NOTATION : 2OV2VO2
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Butanedioic acid, diethyl ester
* Diethylester kyseliny jantarove
* Diethyl succinate
* Ethyl succinate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
REACTION SEVERITY
:
:
:
:
:
Standard Draize test
Administration onto the skin
Rodent - rat
100%
Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,707,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100%
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,707,1978
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,374,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8530 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3671
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 82 (estimated)
No. of Female Employees: 14 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYLALUMINUM CHLORIDE
RTECS NUMBER
: BD0558000
CHEMICAL NAME
: Aluminum, chlorodiethylCAS REGISTRY NUMBER
: 96-10-6
LAST UPDATED
: 199907
DATA ITEMS CITED
: 14
MOLECULAR FORMULA
: C4-H10-Al-Cl
MOLECULAR WEIGHT
: 120.57
SYNONYMS/TRADE NAMES :
* Chlorodiethylaluminum
* Diethylaluminum chloride
* Diethylaluminum monochloride
* Diethylchloroaluminum
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 11 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1215,1986
*** REVIEWS ***
ACGIH TLV-TWA 2 mg(Al)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2 mg(Al)/m3 JAN 1993
OEL-BELGIUM:TWA 2 mg(Al)/m3 JAN 1993
OEL-DENMARK: TWA 2 mg(Al)/m3, JAN1999
OEL-THE NETHERLANDS:TWA 2 mg(Al)/m3 JAN 1993
OEL-RUSSIA:TWA 2 mg(Al)/m3 JAN 1993
OEL-SWEDEN:TWA 2 mg(Al)/m3 JAN 1993
OEL-SWITZERLAND:TWA 2 mg(Al)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2 mg(Al)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6233
No. of Facilities: 14 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 2506 (estimated)
No. of Female Employees: 328 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYLAMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
HZ8750000
Diethylamine
109-89-7
199907
53
C4-H11-N
73.16
2M2
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* DEN
* Diaethylamin
* Diethamine
* N,N-Diethylamine
* Diethylamine
* Dietilamina
* Dwuetyloamina
* Ethanamine, N-ethyl*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 5/21/1971
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
1,343,1960
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
1,343,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 31,238,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - somnolence (general depressed activity)
REFERENCE :
BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233,
Berlin DDR-1086, Ger. Dem. Rep.) V.421983Volume(issue)/page/year:
44,795,1985
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3 gm/m3/2H
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Lungs, Thorax, or Respiration - acute pulmonary edema
Liver - fatty liver degeneration
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 20(4),28,1955
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 585 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 97,1117,1977
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 gm/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - emphysema
Liver - fatty liver degeneration
REFERENCE :
12OVAW "Voprosy Promyshlennoi Toksikologii," Pravdin, N.S., ed.,
Akademiya
Meditsinskikh Nauk-SSSR, Moscos, Russia, 1960 Volume(issue)/page/year:
-,176,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 820 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 5000 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 14,80,1975
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4994 mg/kg/11W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 30(9),28,1965
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 ppm/6H/24W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Immunological Including Allergic - other immediate (humoral): urticaria,
allergic rhinitis, serum sickness
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 6,559,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 mg/m3/24H/93D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(1),28,1968
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 50 uL/plate
REFERENCE :
EJMBA2 Egyptian Journal of Microbiology. (National Information and
Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)
V.71972- Volume(issue)/page/year: 16,133,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Microorganism - not otherwise specified
: 400 uL/plate
EJMBA2 Egyptian Journal of Microbiology. (National Information and
Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)
V.71972-
Volume(issue)/page/year: 15,113,1980
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 200 uL/plate
REFERENCE :
EJMBA2 Egyptian Journal of Microbiology. (National Information and
Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)
V.71972- Volume(issue)/page/year: 15,113,1980
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 45 mg/m3 (15 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 15 mg/m3 (5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office
Dept.
223, POB 57136, West End Stn., Washington, DC 20037) V.11924Volume(issue)/page/year: 9,389,1931
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 25 ppm (75 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,84,1971
OSHA PEL (Gen Indu):8H TWA 25 ppm (75 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 25 ppm (75 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
Volume(issue)/page/year:
OSHA PEL (Shipyard):8H TWA 25 ppm (75 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 25 ppm (75 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 ppm (30 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 10 ppm (30 mg/m3), JAN1999
OEL-AUSTRIA:TWA 10 ppm (30 mg/m3) JAN 1993
OEL-BELGIUM:TWA 10 ppm (30 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993
OEL-FINLAND:STEL 10 ppm (30 mg/m3);Skin JAN 1993
OEL-JAPAN: OEL 10 ppm (30 mg/m3), JAN1999
OEL-GERMANY:TWA 10 ppm (30 mg/m3) JAN 1993
OEL-HUNGARY:TWA 30 mg/m3;STEL 60 mg/m3 JAN 1993
OEL-JAPAN:TWA 10 ppm (30 mg/m3) JAN 1993
OEL-POLAND: MAC(TWA) 30 mg/m3, MAC(STEL) 75 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 10 ppm (30 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 25 ppm (75 mg/m3) JAN 1993
OEL-RUSSIA:TWA 10 ppm;STEL 30 mg/m3;Skin JAN 1993
OEL-SWEDEN:TWA 10 ppm (30 mg/m3);STEL 15 ppm (45 mg/m3);Skin JAN 1993
OEL-SWITZERLAND:TWA 10 ppm (30 mg/m3);STEL 20 ppm (60 mg/m3) JAN 1993
OEL-TURKEY:TWA 25 ppm (75 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (30 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIETHYLAMINE-air:10H TWA 10 ppm;STEL 25 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24680
No. of Facilities: 2138 (estimated)
No. of Industries: 20
No. of Occupations: 28
No. of Employees: 34647 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24680
No. of Facilities: 1387 (estimated)
No. of Industries: 22
No. of Occupations: 24
No. of Employees: 28361 (estimated)
No. of Female Employees: 6878 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Amines, aliphatic, 2010
NTP Carcinogenesis studies; selected, May 1999
OSHA ANALYTICAL METHOD #41
DIETHYLAMINE HYDROCHLORIDE
RTECS NUMBER
: IA3084000
CHEMICAL NAME
: Diethylamine, hydrochloride
CAS REGISTRY NUMBER
: 660-68-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C4-H11-N.Cl-H
MOLECULAR WEIGHT
: 109.62
WISWESSER LINE NOTATION : 2M2 &GH
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Diethylammonium chloride
* N-Ethylethanamine hydrochloride
* Ethanamine, N-ethyl-, hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(1),71,1984
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 31(1),49,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 960 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 17,475,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 112,36,1957
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intravenous
Rodent - mouse
320 mg/kg
V.4-
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 112,36,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 9500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(1),71,1984
V.4-
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 546 mg/kg/26W-I
TOXIC EFFECTS :
Liver - liver function tests impaired
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(1),71,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0052
No. of Facilities: 111 (estimated)
No. of Industries: 3
No. of Occupations: 19
No. of Employees: 3208 (estimated)
No. of Female Employees: 1215 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-forward mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYLAMINO PENTANONE (5:2-)
RTECS NUMBER
: SA8400000
(V/O
CHEMICAL NAME
: 2-Pentanone, 5-(diethylamino)CAS REGISTRY NUMBER
: 105-14-6
BEILSTEIN REFERENCE NO. : 1749398
REFERENCE
: 4-04-00-01935 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C9-H19-N-O
MOLECULAR WEIGHT
: 157.29
WISWESSER LINE NOTATION : 2N2&3V1
SYNONYMS/TRADE NAMES :
* DF 493
* 1-(Diethylamino)-4-pentanone
* 5-Diethylamino-2-pentanone
* Novalketone
* Novol ketone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 145,233,1963
DIETHYLAMINO SALICYLALDEHYDE (4-)
RTECS NUMBER
: CU5615150
CHEMICAL NAME
: Benzaldehyde, 4-(diethylamino)-2-hydroxyCAS REGISTRY NUMBER
: 17754-90-4
LAST UPDATED
: 199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C11-H15-N-O2
MOLECULAR WEIGHT
: 193.27
SYNONYMS/TRADE NAMES :
* 4-(Diethylamino)-2-hydroxybenzaldehyde
* p-(Diethylamino)salicylaldehyde
* 4-(Diethylamino)salicylaldehyde
* Salicylaldehyde, 4-(diethylamino)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rat
V.4-
DOSE/DURATION
: 2262 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533628
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1131 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533628
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHYLAMINOETHYL CHLORIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
(2-)
YE1050000
Triethylamine, 2-chloro-, hydrochloride
869-24-9
199712
21
C6-H14-Cl-N.Cl-H
172.12
G2N2&2 &GH
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bis(ethyl)-2-chloroethylamine hydrochloride
* 2-Chloro-N,N-diethylethanamine hydrochloride
* beta-Chloroethyldiethylamine hydrochloride
* (2-Chloroethyl)diethylamine hydrochloride
* 2-Chlorotriethylamine hydrochloride
* Diethylaminoethyl chloride hydrochloride
* beta-Diethylamino-ethyl chloride hydrochloride
* Diethyl-beta-chloroethylamine hydrochloride
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539174
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539174
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555391
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 103 mg/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539175
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,
USA,
1255 Howard St., San Francisco, CA 94103)
Volume(issue)/page/year: 8,807,1960
V.6-
1958-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 14,111,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 71 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 94,249,1948
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
V.1-
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rabbit
125 mg/kg
1909/10-
Gastrointestinal - other changes
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539174
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,315,1972
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 umol/L
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 31,67P,1979
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST
TEST SYSTEM
: Sister chromatid exchange
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 8,1697,1987
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 22 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,33,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7462
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 4354 (estimated)
No. of Female Employees: 729 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHYLAMINOPROPYNE (3:1-)
RTECS NUMBER
: UK5775000
CHEMICAL NAME
: 2-Propynylamine, N,N-diethylCAS REGISTRY NUMBER
: 4079-68-9
BEILSTEIN REFERENCE NO. : 1098468
REFERENCE
: 4-04-00-01136 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C7-H13-N
MOLECULAR WEIGHT
: 111.21
WISWESSER LINE NOTATION : 2N2&2UU1
SYNONYMS/TRADE NAMES :
* 3-(Diethylamino)propyne
* Diethylpropargylamine
* N,N-Diethyl-2-propynylamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1540 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 570 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0272
No. of Facilities: 352 (estimated)
No. of Industries: 4
No. of Occupations: 10
No. of Employees: 5105 (estimated)
No. of Female Employees: 1155 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
DIETHYLAMMOMIUM DIETHYLDITHIOCARBAMIC ACID
RTECS NUMBER
: EZ5425000
CHEMICAL NAME
: Carbamic acid, diethyldithio-, compd. with
diethylamine (1:1)
CAS REGISTRY NUMBER
: 1518-58-7
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C5-H11-N-S2.C4-H11-N
MOLECULAR WEIGHT
: 222.45
WISWESSER LINE NOTATION : SUYSHN2&2 &K2&2
SYNONYMS/TRADE NAMES :
* Carbamodithioic acid, diethyl-, compd. with N-ethylethanamine (1:1)
* Contramine
* Diaethylammonium-diaethyldithiocarbamat
* Diethylammonium diethyldithiocarbamate
* Diethyldithiocarbamic acid diethylammonium salt
* USAF EK-2635
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
DIETHYLBENZENE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* o-Diethylbenzene
:
:
:
:
:
:
:
:
:
:
CZ5640000
Benzene, o-diethyl135-01-3
1904392
4-05-00-01065 (Beilstein Handbook Reference)
199710
5
C10-H14
134.24
2R B2
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde,
H.,
New York, Elsevier, 1960 Volume(issue)/page/year: -,57,1960
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 mg/kg/8W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Behavioral - muscle weakness
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 12,343,1992
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2118
No. of Facilities: 13 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 279 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
DIETHYLDITHIOCARBAMIC ACID SODIUM
RTECS NUMBER
: EZ6550000
CHEMICAL NAME
: Carbamic acid, diethyldithio-, sodium salt,
trihydrate
CAS REGISTRY NUMBER
: 20624-25-3
LAST UPDATED
: 199903
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C5-H10-N-S2.Na.3H2-O
MOLECULAR WEIGHT
: 225.33
WISWESSER LINE NOTATION : SUYS&N2&2 &-NA- &QH 3
COMPOUND DESCRIPTOR
: Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Diethyldithiocarbamate sodium trihydrate
* Diethyldithiocarbamic acid sodium salt trihydrate
* Diethyldithiokarbaman sodny trihydrat
* Dithiocarb trihydrate
* Sodium diethyldithiocarbamate trihydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove
Rd., Thorofare, NJ 08086) New series: V.11841Volume(issue)/page/year:
235,26,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove
Rd., Thorofare, NJ 08086) New series: V.11841Volume(issue)/page/year:
235,26,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove
Rd., Thorofare, NJ 08086) New series: V.11841Volume(issue)/page/year:
235,26,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 952 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands) V.11967Volume(issue)/page/year:
9,183,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
46,2751,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
8,329,1952
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 5100 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
24,181,1994
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Lymphocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 35,1052,1985
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
400,169,1998
DIETHYLENE GLYCOL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
ID5950000
Diethylene glycol
111-46-6
0969209
4-01-00-02390 (Beilstein Handbook Reference)
199907
59
C4-H10-O3
106.14
Q2O2Q
Tumorigen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bis(2-hydroxyethyl) ether
* Brecolane ndg
* Deactivator E
* DEG
* Dicol
* Diethylenglykol
* Diglycol
* Dihydroxydiethyl ether
* beta,beta'-Dihydroxydiethyl ether
* 2,2'-Dihydroxyethyl ether
* Dissolvant APV
* Ethanol, 2,2'-oxydi* Ethylene diglycol
* 3-Oxapentane-1,5-diol
* 3-Oxa-1,5-pentanediol
* 2,2'-Oxybisethanol
* 2,2'-Oxydiethanol
* 2,2'-Oxyethanol
* TL4N
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 112 mg/3D (Intermittent)
REACTION SEVERITY
: Mild
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"
Drill,
V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
TYPE OF TEST
ROUTE OF EXPOSURE
: Standard Draize test
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,731,1969
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg
REACTION SEVERITY
: Mild
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 42,355,1931
V.1-
1909/10-
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 21,173,1939
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Liver - other changes
Nutritional and Gross Metabolic - metabolic acidosis
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63141) V.11932- Volume(issue)/page/year:
109,731,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12565 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,25,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,3836,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,
Clayton,
G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
Volume(issue)/page/year: 2C,3836,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6565 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,25,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7826 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 59,93,1937
V.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15650 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
1909/10-
Behavioral - excitement
Gastrointestinal - nausea or vomiting
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(3),16,1968
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 23700 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - muscle weakness
Liver - other changes
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 4,142,1945
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 130 mg/m3/2H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - excitement
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 10(12),30,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9719 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Kidney, Ureter, Bladder - changes in both tubules and glomeruli
Blood - changes in spleen
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 6,342,1947
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
V.1-
1909/10-
Volume(issue)/page/year: 42,355,1931
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Gastrointestinal - nausea or vomiting
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(3),16,1968
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 67,101,1939
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 3300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 21,173,1939
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4400 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 21,173,1939
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED