Additional files Additional file 1 – Search strategy PubMed 16-08-2012 (via NCBI) Concept ‘depression’ 1. “Depression”[MeSH] 2. "Depression, Postpartum"[Mesh] 3. "Depressive Disorder, Major"[Mesh] 4. "Dysthymic Disorder"[Mesh] 5. Depress* 6. Dysthymi* 7. 1 OR 2 OR 3 OR 4 OR 5 OR 6 Concept ‘effectiveness’ 8. "Evaluation Studies as Topic"[Mesh] 9. "Treatment Outcome"[Mesh] 10. "Program Evaluation"[Mesh] 11. "Comparative Effectiveness Research"[Mesh] 12. "Clinical Trials as Topic"[Mesh] 13. "Clinical Trial" [Publication Type] 14. 8 OR 9 OR 10 OR 11 OR 12 OR 13 Concept ‘IPT’ 15. Interpersonal 16. “Psychotherapy”[MeSH] 17. Interpersonal therapy 18. Interpersonal psychotherapy 19. IPT 20. 15 OR 16 OR 17 OR 18 OR 19 21. 7 AND 14 AND 20 22. “Adolescent”[MeSH] 23. “Aged”[MeSH] 24. 22 OR 23 25. (21) NOT 24 Limits English, Dutch, Adult: 19-44 years, Middle Aged: 45-64 years, Publication Date from 1970/01/01 to 2012/08/01 Search String (with limitations): (#21) NOT #24 AND (("1970/01/01"[PDAT] : "2012/08/01"[PDAT]) AND (Dutch[lang] OR English[lang]) AND ("adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms])) Overall results: 2469 1 PsycINFO 21-08-2012 Concept ‘depression’ 1. exp Major Depression/ 2. exp Postpartum Depression/ 3. Dysthymi*.af. 4. 1 or 2 or 3 Concept ‘effectiveness’ 5. exp Treatment Effectiveness Evaluation/ 6. exp Mental Health Program Evaluation/ 7. exp Psychotherapeutic Processes/ 8. exp Treatment/ 9. exp Treatment Outcomes/ 10. exp Psychotherapeutic Outcomes/ 11. exp Clinical Trials/ 12. 5 or 6 or 7 or 8 or 9 or 10 or 11 Concept ‘IPT’ 13. exp Interpersonal Psychotherapy/ 14. interpersonal therapy.af. 15. interpersonal psychotherapy.af. 16. IPT.af. 17. 13 or 14 or 15 or 16 18. 4 AND 12 AND 17 Limits Publication Year from: 1970-Current; Age Groups: Adulthood (18 yrs & older), Young Adulthood (18-29 yrs), Thirties (30-39 yrs), Middle Age (40-64 yrs); Languages: English, Dutch Results after limitations: 993 Overall results after deleting duplicates: 3329 Additional file 2 – Checklist The Delphi List 1. Was a method of randomization performed? 2. Was the treatment allocation concealed? 3. Were the groups similar at baseline regarding the most important prognostic indicators? 4. Were the eligibility criteria specified? 5. Was the outcome assessor blinded? 6. Were point estimates and measures of variability presented for the primary outcome measures? 7. Did the analysis include an intention-to-treat analysis? 2 Risk of bias tool 1. Random sequence generation (selection bias) 2. Blinding of outcome assessment (detection bias) 3. Incomplete outcome data (attrition bias) 4. Selective reporting (reporting bias) Additional file 3 – List of excluded studies Excluded studies with reason for exclusion Study Ablon, et al., 2002 Agosti, et al., 1997 Barber, et al., 1996 Blanco, et al., 2001 Blom, et al., 2010 Blom, et al., 1996 Blom, et al., 2007 Bressi, et al., 2010 Brown, et al., 1996 Brown, et al., 1999 Browne, et al., 2002 Bulmash, et al., 2009 Carter, et al., 2011 Cascalenda, et al., 2002 Coulehan, et al., 1997 Croghan, et al., 1999 Cuijpers, Dekker, et al., 2009 Cuijpers, et al., 2005 Cuijpers, et al., 2011 Cuijpers, Van Straten, Bohlmeijer, et al., 2010 Cuijpers, Van Straten, Hollon, et al., 2010 Cuijpers, Van Straten, Schuurmans, et al., 2010 Cuijpers, Van Straten, Van Oppen, et al., 2008 Cuijpers, Van Straten, et al., 2009 Cuijpers, Van Straten, Warmerdam, et al., 2008 De Maat, et al., 2007 De Mello, et al., 2005 De Mello, et al., 2001 Dorrepaal, et al., 1998 Dunner, 2001 Elkin, et al., 1995 Frank, et al., 1990 Frank, et al., 2000 Godfrin, et al., 2010 Guidi, et al., 2011 Hollon, et al., 2005 Hollon, et al., 2010 Imber, et al., 1990 Jakobsen, et al., 2011 Kim, 2003 Reason for exclusion Based on other study Based on other study Based on other study No research data Based on other study No comparison in the study Based on other study Not IPT as described in eligibility criteria Based on other study Based on other study Wrong diagnosis Wrong aim of the study Based on other study Review and/or meta-analysis Based on other study Not IPT as described in eligibility criteria Review and/or meta-analysis Not IPT as described in eligibility criteria Review and/or meta-analysis Review and/or meta-analysis Review and/or meta-analysis Review and/or meta-analysis Review and/or meta-analysis Review and/or meta-analysis No research data Review and/or meta-analysis Review and/or meta-analysis Not IPT as described in eligibility criteria Review and/or meta-analysis No research data Based on other study Not IPT as described in eligibility criteria Wrong aim of the study Not IPT as described in eligibility criteria Review and/or meta-analysis Review and/or meta-analysis Review and/or meta-analysis Based on other study Review and/or meta-analysis Based on other study 3 Kingston, et al., 2007 Kotova, 2005 Kriston, et al., 2010 Kushner, et al., 2009 Lave, et al., 1998 Markowitz, 1994 Markowitz, 1996 Markowitz, et al., 2005 Miller, et al., 1996 Pampallona, et al., 2004 Reinceke, et al., 2000 Reynolds, et al., 1996 Schene, et al., 2007 Schulberg, et al., 1997 Schulberg, et al., 1995 Segal, et al., 2001 Shea, et al., 1992 Svanborg, et al., 2008 Thase, et al., 1997 Van Roijen, et al., 2006 Watkins, et al., 2003 Weissman, 2007 Not IPT as described in eligibility criteria Review and/or meta-analysis Protocol for a study Wrong aim of the study Based on other study Wrong diagnosis Wrong diagnosis Wrong diagnosis No research data Review and/or meta-analysis No research data Based on other study Not IPT as described in eligibility criteria Not IPT as described in eligibility criteria Wrong aim of the study Based on other study Based on other study Wrong diagnosis Review and/or meta-analysis Not IPT as described in eligibility criteria Based on other study Review and/or meta-analysis 4