The 14th SCBA International Symposium Program Date: July 18-22, 2013 Venue: Wanda Hilton Hotel, Xi’an, China Thursday, July 18th, All Day Registration (The Hilton Xi’an Hotel) Friday, July 19th, Morning 1. Opening Ceremony (Chair: Zhi-Nan Chen) 08:30-09:20 Welcome Speeches Opening Remarks 2. Keynote Lecture I (Chairs: Xiao-Fan Wang, Zhi-Nan Chen) 09:20-10:00 Zhu Chen, Shanghai Ruijin Hospital, Shanghai, China From Cure of Leukemia to Universal Coverage 3. Presidential Award Lecture (Chairs: Xiao-Fan Wang, Zhi-Nan Chen) 10:10-10:50 Xiaodong Wang, National Institute of Biological Sciences, Beijing, China Biochemical Pathway of Programmed Necrosis 10:50-11:00 Tea Break 4. Plenary Lecture I (Medicine & Health: Molecular Medicine), 11:00-12:00 (Chairs: Jim Hu, Xin-Hua Feng) 11:00-11:20 Yang Shi, Harvard Medical School and Boston Children’s Hospital, Boston, USA A Histone Methylation Network Regulates Epigenetic Inheritance 11:20-11:40 Xuetao Cao, Chinese Academy of Medical Sciences, Beijing, China TBA 11:40-12:00 Feng Shao, National Institute of Biological Sciences & Howard Hughes Medical Institute, Beijing, China Biochemical Dissection of Bacterial Virulence & Macrophage Innate Immunity Friday, July 19th, Afternoon 5. Keynote Lecture II, 13:30-14:10 (Chairs: Xuetao Cao, Yang Shi) 13:30-14:10 Jules Hoffmann, National Center of Scientific Research (CNRS), Strasbourg, France Innate Immunity: From Flies To Humans 6. Plenary Lecture II (Medicine & Health: Stem Cell & Epigenetics), 14:10-17:10 (Chairs: Xuetao Cao, Yang Shi) 14:10-14:30 14:30-14:50 14:50-15:10 15:10-15:30 15:30-15:40 Haifan Lin, Yale University, New Haven, USA A Major Epigenetic Programming Mechanism Guided by piRNAs Qi Zhou, Institute of Zoology, Chinese Academy of Sciences, Beijing, China Cell Fate Determination and Regulation – the Hope of Medical Revolution Jinsong Li, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China Generation of Mammalian Haploid Embryonic Stem Cells Yibin Kang, Princeton University, Princeton, USA Tumor-Stromal Interactions in Breast Cancer Bone Metastasis Tea Break 7. Plenary Lecture III (Agriculture & Plant Sciences), 15:40-17:00 (Chairs: Xiaoya Chen, Qifa Zhang) 15:40-16:00 Xinnian Dong, Duke University & Howard Hughes Medical Institute, Durham, USA Dynamic Regulation of Plant Immune Response 16:00-16:20 Jiayang Li, Institute of Genetics & Developmental Biology, Chinese Academy of Sciences, Beijing, China The Role of Phytohormones in Regulation of Plant Architecture 16:20-16:40 Jiankang Zhu, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China An ABA Mimicking Ligand that Reduces Water Loss and Promotes Drought Resistance in Plants 16:40-17:00 Qifa Zhang, Huazhong Agricultural University, Wuhan, China Understanding Reproductive Isolation Based on the Rice Model 8. Banquet, 17:40-19:30 Saturday, July 20th, Morning 1、 Life Achievement Award Lecture, 08:15-08:50 (Chairs: TC Wu, Richard Zhao) 08:15-08:50 Sophia & Ming-Jer Tsai, Baylor College of Medicine, Houston, USA The Role of COUP-TFII in Development and Diseases 2、 Plenary Lecture IV (Medicine & Health), 09:00-11:00 (Chairs: Yigong Shi, Xifeng Wu) 08:50-09:10 Xinyuan Liu , Zhejiang Science and Technology University, Hangzhou, China TBA 09:10-09:30 Zhinan Chen, The Fourth Military Medical University, Xi’an, China TBA 09:30-09:50 Xifeng Wu, M.D. Anderson Cancer Center, Houston, USA Health Screening Cohort: A New Avenue for Risk Prediction, Prevention, and Early Detection Research 09:50-10:10 Yinghao Sun, The Second Military Medical University, Shanghai, 10:10-10:20 10:20-10:40 10:40-11:00 China TBA Tea Break Shumin Duan, Zhejiang University, Hangzhou, China Purine-mediated Signaling in Glial Cells Ning Yan, Tsinghua University, Beijing, China Structural Investigation of Voltage-gated Na+ Channels 3、 KT Jeang Memorial Lectures,11:00-11:40 (Chairs: Zhiming Zheng, Dihua Yu) 11:00-11:20 Wei Yang, National Institutes of Health, Bethesda, USA Catalysis of a Chemical Bond Formation at Atomic Resolution and Real Time 11:20-11:40 Wenhui Li, National Institute of Biological Sciences, Beijing, China Reveal a Major Secret of HBV Infection: NTCP is a Functional Receptor for Hepatitis B and D Virus 4、 Junior Investigator Award Lecture, 11:40-12:00 (Chairs: Zhiming Zheng, Dihua Yu) 11:40-12:00 Hui-Kuan Lin, M.D. Anderson Cancer Center, Houston, USA Targeting Ubiquitination Pathways for Cancer Therapy Saturday, July 20th, Afternoon 1. Concurrent Sessions,13:30-15:00 Program Kuan-Teh Jeang Memorial Symposium on Virus-Host Interaction CBA Symposium: New Strategies and Novel Platforms for Drug Discovery and Development Novel Strategies for Subunit Vaccines Development Stress and Epigenetics of Plants Nuclear receptors: from Basic Science to Diseases Tumor Immune Environment Session Chairs Chou-Zen (Joe) Giam and Zhi-Ming Zheng Yingxian Xiao, Jian Ni, Dajun Yang, Patrick Y. Lu, Ping Chen, Richard Zhao Ting-Fang Wang/ Chih-Hsiang Leng Jian-Kang Zhu Ming-Jer Tsai/ Yunbo Shi Weiping Zou/ Li-Hua Chen Location Hanzhong Room Xianyang Room Yan’an Room Yulin Room A Yulin Room B Shenmu VIP Room 2. Concurrent Sessions,15:00-16:30 Program Kuan-Teh Jeang Memorial Symposium on Molecular Mechanisms of Host-Pathogen Interaction and Their Implications in Therapeutic Approaches Symposium: New Strategies and Novel Platforms for Drug Discovery and Development Vaccine Technology Crop Polyploidy and Genome Evolution Gene Regulation and RNA Processing Cancer Metabolism and Therapeutics Session Chairs Peter Sun/ Wei Yang Yingxian Xiao, Jian Ni, Dajun Yang, Patrick Y. Lu, Ping Chen, Richard Zhao Pele Chong/ R Holland Cheng Qixin Sun/Liu Bao Soo-Chen Cheng Hsing-Jien Kung/ Zhimin Lu Location Hanzhong Room Xianyang Room Yan’an Room Yulin Room A Yulin Room B Shenmu VIP Room 3. Concurrent Sessions,16:30-18:00 Program HIV and Host Factor Interactions Symposium: New Strategies and Novel Platforms for Drug Discovery and Development Regulation of Immune Responses Session Chairs Li Wu Yingxian Xiao, Jian Ni, Dajun Yang, Patrick Y. Lu, Ping Chen, Richard Zhao Bing Su/Chen Dong Plant Innate Immune System and Disease Resistance Gene Regulation and RNA Biology Zuhua He/ Jianmin Zhou Burton B Yang/ Chun Peng Prostate Cancer Perspectives Sophia Tsai/ Jianming Xu 4. To Visit Tang Paradise,18:10-21:30 Location Hanzhong Room Xianyang Room Yan’an Room Yulin Room A Yulin Room B Shenmu VIP Room Sunday, July 21st, Morning 1. Concurrent Sessions,08:00-09:30 Program Kuan-Teh Jeang Memorial Symposium on Pathogenesis of Emerging Viral Pathogens Genomic and Epigenomic Instability: Causes and Survival Mechanisms Structural and Chemical Biology of Signaling Proteins and Virulent Factors New Insights on Epigenetic Modification, Inflammation and Metabolic Diseases Mechanobiology Posttranslational Regulation and Cellular Signaling in Cancer and Therapeutics Session Chairs Li-Min Huang/ Sui-Yuan Chang Binghui Shen/ Guang Peng Zhong-Yin Zhang Chuxia Deng/ Min You Choy Leong HEW/ Boon Chuan Low Shi-Yuan Cheng/ Zhimin Lu Location Hanzhong Room Xianyang Room Yan’an Room Yulin Room A Yulin Room B Shenmu VIP Room 2. Concurrent Sessions,09:30-11:00 Program Pathogenesis of Emerging Bacterial Pathogens DNA Repair and Genome Instability Research in China Molecular Mechanism Underlying Tumor Aggressiveness and Response to Anti-Cancer Therapy Immunometabolism in Diseases Bionanomotors for the Transportation of Macromolecules in Cells Breast Cancer Development Session Chairs Cheng-Hsun Chiu/Jin-Town Wang Guo-Min Li/ Xingzhi Xu Jian Jian Li/ Xinbin Chen Location Hanzhong Room Xianyang Room Li-Na Wei/ Chih-Hao Lee Peixuan Guo/ Carlos Montemagno Yi Li/Zhixiong Xiao Yulin Room A Yulin Room B Shenmu VIP Room Session Chairs Han-Chung Wu/ Wan Wan Lin Location Hanzhong Room Yan’an Room 3. Concurrent Sessions,11:00-12:30 Program Pathogenesis and Therapy of Flavivirus Understanding Genomic Instability in the Age of Genomics Zebrafish for Regeneration Study and Drug Development The Cellular and Molecular Basis for Repair and Regeneration Nanotheranostics Plant Reproduction Junjie Chen/ Lee Zou Bon-chu Chung/ Anming Meng Wei Li/ Xiao-Jing Wang Xiaoyuan Chen/Feng Cao Dabin Zhang/ Xingwang Deng (Shawn) Xianyang Room Yan’an Room Yulin Room A Yulin Room B Shenmu VIP Room 4. Concurrent Sessions:Rheumatology and Clinical Immunology,08:30-12:00 Sunday, July 21st, Afternoon 1. Concurrent Sessions,13:30-15:00 Program TGF-beta Signaling and Beyond Hepatitis C Virus and Host Interactions The Fly Brain: Circuits and Behavior Stem Cell Induction and Differentiation Autophagy in Development and Disease I The DNA Damage Response and Cancer Session Chairs Ye-Guang Chen/ Xin-Hua Feng J. H. James Ou/ Guangxiang George Luo Y. Henry Sun/Aike Guo Zhenkun Lou/ Zhiyuan Shen Location Hanzhong Room Xianyang Room Yan’an Room Yulin Room A Yulin Room B Shenmu VIP Room Session Chairs Bangyan Stiles/ Hua Yu Qigui Yu/ Johnny He Location Hanzhong Room Xianyang Room Sheng Ding/ Ting Xie Qing Zhong 2. Concurrent Sessions,15:00-16:30 Program Liver Disease and Cancer HIV/AIDS: Pathogenesis and Strategies for an HIV/AIDS Cure New Treatment Strategies in Neurodegenerative and Neurological Diseases Stem Cells, Reprogramming, Cell Therapy Autophagy in Diseases and Development II Mechanisms of Therapeutic Resistance in Cancer Xiaoming Ou/ Junming Wang Lei Xiao/Xin Chen Yu Li Yun Qiu/ Zhou Songyang Yan’an Room Yulin Room A Yulin Room B Shenmu VIP Room 3. Concurrent Sessions,16:30-18:00 Program New Frontier in Cancer Metastasis Session Chairs Dihua Yu/ Yibin Kang Innate Immune Signaling and Rongfu Wang/ Immunotherapy Hua Yu Gene Therapy: a Frontier of Genomics Xiao Xiao and Personalized Medicine Stem Cell and Neuroscience Duanqing Pei/ Xiaoqun Wang Nutraceutical and Other Novel Tianru Jin/ Therapeutic Approaches for Metabolic Wenhuan Lin Disorders Regulation of Cancer Cell Zhije Chang/ Proliferation and Tumorigenesis Eugene Chin Location Hanzhong Room Xianyang Room Yan’an Room Yulin Room A Yulin Room B Shenmu VIP Room 4. Concurrent Sessions:Rheumatology and Clinical Immunology,13:30-16:00 Monday, July 22nd, Morning 1. Plenary Lecture V (Medicine & Health: From Bench to Bedside), 08:30-11:20 (Chairs: Mien-Chie Hung, Xiaodong Wang) 08:30-08:50 Yigong Shi, Tsinghua University, Beijing, China A Tale of TALE 08:50-09:10 Chuan He, University of Chicago, Chicago, USA Reversible RNA Methylation in Regulating Protein Expression 09:10-09:30 Soo-Chen Cheng, Academia Sinica, Taipei Spliceosome Dynamics in the Catalytic Steps of RNA Splicing 09:30-09:50 Tak W. Mak, University of Toronto, Ontario, Canada TBA 09:50-10:00 Tea Break 10:00-10:20 Jude Samulski, University of North Carolina, USA 10:20-10:40 10:40-11:00 11:00-11:20 11:20-11:40 TBA Zhijian Chen, University of Texas Southwestern Medical Center & Howard Hughes Medical Institute, Dallas, USA Innate Immune Sensing and Signaling of Cytosolic DNA Yongzhang Luo, Tsinghua University, Beijing, China Fu Gao, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China TBA Yong Hei, Global Development Department of Amgen, Shanghai, China TBA 2. Closing Ceremony (Chair: Xiao-Fan Wang) 11:40-12:00 Abstract/poster award presentation Closing remarks