BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Dipanjan Pan, Ph.D.
Research Instructor of Medicine
eRA COMMONS USER NAME
DIPANJANPAN
EDUCATION / TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Vidyasagar University, WB, India
Vidyasagar University, WB, India
Indian Institute of Technology, Kharagpur, India
Postdoctoral Research Associate, Washington
University in Saint Louis, MO
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
B.S.
1995
Chemistry
M.S.
1997
Organic Chemistry
Ph.D.
2002
Synthetic Chemistry
2002-2005
Polymer Chemistry,
Nano-materials,
Molecular Imaging, Drug
Delivery
Postdoctoral
Research
Associate
A. POSITIONS AND HONORS
Research and Professional Experience:
1998-2000 Junior Research Scholar, Indian Institute of Technology, Kharagpur, India
2000-2002 Senior Research Scholar, Indian Institute of Technology, Kharagpur, India
2002-2005 Postdoctoral Research Associate, Washington University in Saint Louis, MO
2005-2006 IP Analyst, General Electric (GE) Global Research, Biosciences, Bangalore
2006 Diploma on Patent literature searching and litigation aspects, Won, Central Board of GO, Hague,
Netherlands
2006-2007 Postdoctoral Research Associate, Washington University School of Medicine
2007Research Instructor of Medicine, Washington University School of Medicine
Selected Honors and Fellowship Awards:
(1) Corporate Awards: Management Award: 2006; GE Global Research, JFWTC; (2) CSIR, India senior
research fellowship: 2001-2002; (3) Graduate Aptitude Tests in Engineering (GATE): 1997; (4) Indian Institute
of Technology Junior Research Fellowship: 1998-2001; (5) University endowment medals for ‘The Best
Student of the Year’ 1997; (6) University gold medal: 1997 (Master of Science in Organic Chemistry); (7)
University silver medal: 1995 (Bachelor of Science in Chemistry)
US Pending Patents:
Becker ML, Fang H, Li X, Pan D, Rossin R, Sun X, Taylor JS, Turner JL, Welch MJ, Wooley KL. Cell
permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids ("PNAs") with uniquely
expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer.
Washington University. US Pat No. 2006159619
B. SELECTED PEER-REVIEWED PUBLICATIONS
Ray JK, Pan D, Raj S, Fun HK: 7-Methoxy-2 methylnaptho[1,2-b]thiophene. Acta Crystallographica 1999;
C55:1849-1850.
Kar GK, Haldar MK, Gupta S, Pan D, Ray JK: Studies on cavity shaped polycyclic thiaarenes: short and
efficient synthesis of 2,12 dimethylanthra[1,2-b][8,7- b]bisthiophene and anthra[1,2-b]thiophene. J. Ind. Chem.
Soc. 1999; 76:569-573. (Special commemorative issue)
Pan D, Ray JK: Regioselective alkylation of polycyclic thiophene derivatives by butyllithium and alkylhalide.
Synthetic Communications 2000; 30:3569-3573.
Pan D, Roy BC, Kar GK, Ray JK: Highly site selective alkylation reaction of bent aza heterocycles by
alkyllithium and alkyl halides. J. Chem.Soc. Perkin Trans 1 2000; 2171-2173.
Usman A, Razak IA, Chantopromma S, Fun HK, Pan D, Ray JK: 10-Fluoro-6,7-dihydro-5H
benzo[6,7]cyclohepta[1,2-b]quinoline. Acta Crystallographica 2001; E57 (1):o844.
Usman A, Razak IA, Chantopromma S, Fun HK, Pan D, Ray JK: 4,4-Bis (5-carbomethoxy-2-thienyl)phenyl
sulphide. Acta Crystallographica 2001; E57 (1):o842.
Ray JK, Gupta S, Pan D, Kar GK: Molecular Recognition: Studies on the synthesis of some bis
thiophenecarboxamide derivatives as ditopic receptor to long chain dicarboxylic acids. Tetrahedron 2001;
57:7213-7219.
Pan D, Kar GK, Ray JK, Lin JM, Amin S, Fun HK: Studies on cavity shaped polycyclic fluoro azaarenes:
Synthesis of trans-9- fluoro-3,4-dihydroxy 3,4- dihydrobenz[c]acridine and trans- 11-fluoro-3,4- dihydroxy 3,4
dihydrobenz[c]acridine as potential proximate carcinogenic metabolite of fluorobenz[c]acridine. J. Chem. Soc.
Perkin Trans 1 2001; 19:2470-2475.
Pan D, Mal SK, Kar GK, Ray JK: Highly chemoselective method for the synthesis of 4-hydroxy-4allylcyclohexa-2,5-dienone derivatives by indium-mediated allylation protocol. Tetrahedron 2002; 58:28472852.
Ray JK, Roy BC, Pan D, Canle LM, Santaballa JA, Mahia J: 14-n-Butyldibenz[a,h]acridine. Acta
Crystallographica 2003; E59 (4):o514-o516.
Mahato TK, Pan D, Mal SK, Ray JK: Chlorine directed formylation of chloro indanones under Vilsmier-Haack
reaction condition. J. Ind. Chem. Soc. 2003; 80: 969. (special commemorative issue)
Pan D, Kar GK, Ray JK: Indium mediated allylation of beta-chlorovinylaldehydes: a facile one-pot synthesis of
1- chlorohexa-1,5- diene-3-ol derivatives. Synthetic Communications 2003; 3:1- 9.
Pan D, Turner JL, Wooley KL: Folic acid conjugated nanostructured materials designed for cancer cell
targeting. Chemical Communications 2003; 19:2400. (Also highlighted as HOT ARTICLE) (COVER ARTICLE)
Becker ML, Remsen EE, Pan D, Wooley KL: Peptide Derivatized Shell Crosslinked (SCK) Nanoparticles. 1)
Synthesis and Characterization. Bioconjugate Chemistry 2004; 15:699. (COVER ARTICLE-Highlighted)
Brahma S, Pan D, Ray JK: Molecular recognition: studies on the synthesis of methylene pivotal bis-thio
carboxamide derivatives as ditopic receptor for suberic acid. Supramolecular Chemistry 2004; 16:447.
Pan D, Turner JL, Wooley KL: Shell crosslinked nanoparticles designed to target angiogenic blood vessels via
avß3 receptor-ligand interactions. Macromolecules 2004; 37:7109.
Rossin R, Pan D, Qi K, Turner JL, Welch MJ, Wooley KL: 64Cu-labeled folate-conjugated shell cross-linked
nanoparticles for tumor imaging and radiotherapy: synthesis, radio labeling and biological evaluation. J Nucl.
Med. 2005; 46:1210.
Turner JL, Pan D, Plummer R, Chen Z, Whittaker AK, Wooley KL: Synthesis of Gadolinium Labeled Shell
Crosslinked Nanoparticle for Magnetic Resonance Imaging Applications. Adv. Func. Mat. 2005; 15:1248.
C. RESEARCH SUPPORT
Ongoing Research Support
U54 CA119342 (Wickline)
9/30/2005-8/31/2010
National Institutes of Health
The Siteman Center of Cancer Nanotechnology Excellence at Washington University
Project 1 - Neovascular-Directed Nanoparticles for Detection, Characterization and Treatment of
Neoplasia with MRI (Lanza)
The subject of this proposal is the application of a novel paramagnetic site-targeted contrast
"platform technology" for sensitive and specific imaging of molecular epitopes expressed on tumor
neovasculature alone and in combination with the local delivery of chemotherapeutic agents to these
sites.
Role: Researcher
Pending
R01 NS059302 (Lanza)
4/1/2007-3/31/2012
National Institutes of Health
Fibrin-Specific Thrombolytic Nanoparticles for Acute Stroke
The goal of this project is to develop and evaluate fibrin-targeted thrombolytic nanoparticles for
treatment of acute stroke.
Role: Researcher
Completed Research Support
N01-CO-27103 Karen L Wooley (PI)
3/1/2002-6/30/2004
National Cancer Institute
Department of Chemistry at Washington University
Nanoscale Bioconjugates as Passive and Active Detection, Diagnosis and Treatment Systems
The subject of this proposal was the development of polymeric nanoparticle based multi-component
recognition units that will harness the information generated from the human genome project to prepare
devices that can be produced with a few building blocks by an automated process for cancer-specific mRNA
targeting and imaging, and thus, early detection and diagnosis.
Role: Researcher