The Flipnob Clan Remember, to get ANY points you need to put effort into this. I will not consider your extra credit unless it is neatly done and shows that you learned in the process. Do it well or do not do it at all. A. Using the information below, make a pedigree chart for the Flipnob family. This is the story of Grandma and Grandpa Flipnob, and their clan! They were married way back in 1933, and have been just like newlyweds ever since. From their union, 4 individuals were created. Elizabeth, the eldest, was born in 1935. Fred soon followed in 1936. In 1939 Michelle was brought into this world. Mickey (a surprise to the whole family was the baby of the family, not being born until 1950. Elizabeth fell in love at a young age, and wed her high school sweetheart, David, in 1954. From this marriage, two bundles of joy came about (at the same time): John and Sonny - 1955 (twins)! It took Fred a little longer to find his soul mate. Finally in 1970, Fred found the woman of his dreams, Wilma, and they were married. Since they married so late in life, they only brought one new person into this world: Barney – 1972 Michelle was a hard-working woman, and never found time in her schedule for love. She led a very productive and fulfilling life, but she never did marry and have children. Mickey was a wild one!! After a long string of girlfriends, he finally chose Monica to spend the rest of his life with. They were wed in 1975 and brought two girls into this world: Krista – 1977 Janet - 1979 B. Dominant/Recessive Inheritance - Freckles (Having freckles is dominant, not having freckles is recessive) Now that you have your pedigree chart together, lightly shade the appropriate circles and squares for individuals with freckles, from the information below. Grandpa Flipnob did not have freckles, but his beautiful bride did. Fred and Michelle were the only two of their siblings to have freckles. Of the grandchildren, the twins did not have freckles, and neither did Barney, but the two girls did. Determine the genotypes of all individuals in this pedigree chart for freckles, by doing the following: 1.) Assign two recessive genes to any direct relative on the pedigree whose symbol is not shaded. Small letters are written below the person’s symbol. Spouses are unknown at this time. 2.) Assign one dominant gene to any relative on the pedigree whose symbol is shaded. A capital letter is written below the person’s symbol. 3.) Use the information given to you to determine the second alleles for each person with the dominant phenotype. Leave a “?” for alleles you cannot determine with certainty. Chart everyone’s genotype. You should be able to figure out the spouses at this time. 4.) From your results, what is Grandpa’s genotype? What must be the genotypes of their children? What are the genotypes of their grandchildren? 4.) Write a paragraph that explains who in the family definitely has freckles, may have freckles, or does not have freckles. Explain how you know. C. Sex-Linked Inheritance - Colorblindness (Being colorblind is a recessive trait, but it is also sexlinked. That means that it is carried on the X chromosome—and men only need to get one recessive allele—Xc. As always, women need to get two recessive alleles—XcXc. The dominant allele is XC.) To complete this section, you need to code a new characteristic--colorblindness. Do this by cross-hatching the shaded/unshaded circles/boxes. From there, you should be able to determine the genotypes of most of the family by following the above directions for freckles. Write their genotypes either underneath or next to their genotype for freckles. Write another paragraph as above. Neither Grandma or Grandpa Flipnob are colorblind. All of their children have normal color vision, except Mickey. Of the grandchildren, the twins both inherited colorblindness, as did their cousins, Barney and Janet. Are there any other colorblind members of the clan???? Pedigree Extra Credit Project Earning Points: Complete the attached activities about pedigrees. Carefully follow the directions and use the provided information to produce complete pedigrees and predict affected family members. Do not just do the work and turn it in. You should create a report. You may cut and paste the provided pedigree charts or redraw them. If you create a poster, it cannot be larger than 12x18. If it is I will return it ungraded. Use of color and creativity will add points only if the project is neat, complete, and shows strong content. The goal is for you to learn how to use pedigrees to predict gene carriers and to demonstrate that you understand them and can analyze them. This is due Monday, April 1 when you enter the room. No late work is accepted. Background Information: All living things have a pedigree. A pedigree is a diagram that shows the occurrence and appearance of a particular genetic trait as it is passed from one generation to the next in a given family. From this information, along with an understanding of inheritance, genotypes of individuals can often be determined. Although there is some variation in shading and coding, pedigrees are generally done the same way. Before you begin to complete a pedigree, always look at how it is currently coded and how you will continue to code it. Sometimes multiple genes are coded and so different shading is required. Hemophelia