CONTROL OF BASAL METABOLIC RATE BY THE THYROID GLAND
Thyroid Receptors and Actions
Signalling in Health and Disease HT 2011; helen.christian@dpag.ox.ac.uk
Thyroid hormone control of thermogenesis
Silva, JE (2006) Thermogenic mechanisms and their hormonal regulation. Physiol Rev 435-464
Very good review of thyroid and other hormonal control of thermogenesis, good starting point
Haber et al (1988) Time course of Na/K transport and other metabolic responses to thyroid
hormone. Endocrinology 123:238-247
and
Simonides WS et al (1990) Thyroid hormone affects Ca-ATPase mRNA in SR. FEBS Lett
274:73-76
McDonough et al (1988) Am J Physiol 254:C323-9 T3 regulation of Na+-K+ATPase
Bianco AC et al (1987) Intracellular conversion of thyroxine is required for optimal thermogenic
function of brown adipose tissue. J Clin Invest 79:295-300
Branco et al (1999) 3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal
sympathetic activity Am J Physiol. 276(1 Pt 1):E179-87.
Thomas et al (2008) Bile Acids and the Membrane Bile Acid Receptor TGR5—Connecting
Nutrition and Metabolism Thyroid 18(2): 167-174
Knockout mouse models that explore role of thyroid axis in control of BMR/thermogenesis
Brown et al (2000) J Clin Invest 106:73-79 RXR deficiency gives thyroid hormone resistance
Shibusawa et al (2003) Thyroid hormone action in the absence of DNA binding. J Clin Invest
112:588.
Golozoubova et al (2004) Depressed thermogenesis in mice devoid of all hormone-binding TH
receptors. Mol Endocrinol 18:384-401
Marrif H et al (2005) Temperature homeostasis in transgenic mice lacking TRalpha gene.
Endocrinology 146:2872-2884
Gong et al (2000) Lack of obesity and normal response to fasting and thyroid hormone in mice
lacking uncoupling protein 3. J Biol Chem 275:16251-16257
and
Vidal-Puig et al (2000) Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol
Chem 275:16258-16266
De Jesus LQ et al (2001) The type 2 deiodinase is essential for adaptive thermogenesis in brown
adipose tissue. J Clin Invest 108:1379-1385
O’Shea et al (2002) Thyroid hormone receptor knockout mice. J Endocrinol 175:553-570.
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Thyroid hormone control of food intake
Kong et al (2004) Triiodothyronine Stimulates Food Intake via the Hypothalamic Ventromedial
Nucleus Independent of Changes in Energy Expenditure Endocrinology 145: 5252-5258
Reinehr (2010) Obesity and thyroid function. Mol Cell Endocrinol 316: 165-71
Thyroid receptors
Forrest et al (1996) Rec Prog Horm Res 51:1-22 Genetic analysis of T receptors in development
& disease
Dace et al (2000) PNAS 97:8985-8990 Hormone binding induces proteosome degradation of T
receptors
Schapira et al (2003) Discovery thyroid hormone receptor antagonists. PNAS 100:7354-7359
Zhang et al (2000) Annu Rev Physiol 62:439-466 Mechanism of action of thyroid hormones.
Review
Liu & Brent (2010) Thyroid hormone crosstalk with nuclear receptor signaling in metabolic
regulation. Trends Endocrinol Metab 21:166-73
Rapid, ‘non-genomic’ thyroid hormone effects
Davis et al (2008) Mechanisms of non-genomic actions of thyroid hormone.
Neuroendocrinology 29:211-218
Frontiers in
Bergh et al (2005) Integrin contains a cell-surface receptor site for thyroid hormone that is
linked to MAP kinase and induction of angiogenesis. Endocrinology 146:2864-2871
Also see Commentary relating to this article in the same issue p2861 by S Incerpi, Thyroid
hormones: rapid reply by surface delivery only’
Thyroid hormone transport by MCT8
Visser et al (2007) Thyroid hormone transport in and out of cells. Trends Endocrin Metabolism
19:50-56
This group have written many reviews of the discovery of MCT8 and thyroid hormone transport,
any are good reads
Are there BMR problems in the MCT8 KO????CHECK
Brown adipose tissue in humans
Commentary in Nature:
Three articles in New England J Med
Commentary in Endocrinology:
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