XXXIII International Conference on Plasma Physics and CF, February 13 – 17, 2006, Zvenigorod
MATERIALS WITH ANTIMICROBIAL ACTIVITY ON THE BASE OF
NANOSTRUCTURED POLYMERS.
Elinson V.M., *Erastova E.I., Lyamin A.N., Stenin S.S., *Hovanskaya T.P.
“MATI”- Russian Governmental Technological university named by K.E. Tsiolkovsky,
Moscow, Russia, e-mail: vm_e@mail.ru
*
Moscow scientific and research institute named by P.A. Hertzen, Moscow, Russia,
e-mail: mnioi@mail.ru
Last year investigations demonstrated the important and constantly increasing role of synthetic
nanobiomaterials, in particular materials with nanostructured surfaces (NSS). The perspectives for
application of materials with NSS in medicine and biotechnology are connected with the creation
of medicines for external application , in particular transdermal forms, which are absorbed through
the skin, for creation matrixes for internal delivery; with creation of matrixes and substrates for
cultural technique, biocatalysts etc., and other materials and wares possessing antimicrobial
activity, for example, active filters for purification of water and air, packaging materials for
medical and food application, inhibitors for food and parfume industry, etc.
In the present work results of research of the processes for manufacturing NSS on polymeric
materials, their surface characteristics and possibilities for using them. The PET and nuclear track
membraines on this base ( PET TM) with the pore diameter 0,2 µm were chosen as the initial
polymeric materials for study. NSS on PET and PET TM have been formed by treatment of initial
surface by ions of chemically active and noble gases ( tetrafluormethan, argon and air mixture) and
modification of the obtained relief by means of the deposition of carbon films with the thickness
50-120 nm from directed plasma flows of hydrocarbon vapours. Study of the surface by the atomic
force microscope has shown that the carbon film deposition on the treated surface at small
thicknesses has smoothed the relief and at higher thicknesses of carbon films the heght of the
features of microrelief became to increase. The influence of the parameters of pretreatment
processes has been demonstrated. The dependences for the roughness and specific surface of PET
and PET TM on the carbon film thickness were also obtained as for pretreatment by argon ions as
well as by ions of air mixture. It was also established that these dependences were in good
correlation with the measured values of wetting angles.
Application method was used for the study of antimicrobial activity in relation to grampositive
(Staphylococcus aureus АТСС 29213) and gramnegative ( Escherichia coli АТСС 54383 and
Pseudomonas aeruginosa АТСС 27853) microorganisms, as well as in relation to funguses of the
type Candida albicans ( clinical identified stamm ). The correlation of the obtained results with
the surface characteristics of nanostructured materials has been established. Possible mechanisms
of antimicrobial activity are discribed.
References.
[1]. .M.Elinson, V.V.Sleptsov, V.V.Potraysay, A.N. Laymin . Biomedical Properties of
Nanostructured Surfaces Formed by Ion-Plasma Methods. // Nanostructured Thin Films and
Nanodispersion Strengthen Coatings, 307-319. A.A.Voevodin and al.(eds) / 2004 Kluwer
Academic Publishers. Printed in Netherlands.
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