Page 1 Intraoperative TEE Evaluation of Ischemic/Functional Mitral Regurgitation Stanton Shernan, MD, FAHA, FASE Professor of Anaesthesia President, National Board of Echocardiography Director of Cardiac Anesthesia Brigham and Women’s Hospital Department of Anesthesiology, Perioperative and Pain Medicine Harvard Medical School While structural, degenerative disease of the mitral valve remains the most common etiology of surgically treated mitral regurgitation (MR) in the US, patients with functional MR due to ischemia or global left remodeling remains an important cardiac surgical population. Ischemic mitral regurgitation (IMR) is defined as mitral valve (MV) incompetence that occurs directly as a result of coronary artery disease (CAD), and not an intrinsic pathological process. Mechanisms for the development of IMR are dynamic, complex and multifactorial (1). Hypokinesia of left ventricle (LV) segments at the base of the papillary muscle may be more responsible than papillary muscle dysfunction alone for causing retraction of MV leaflets toward the apex and subsequent incomplete leaflet coaptation. Asymmetric MV annular dilatation can also interfere with normal leaflet coaptation and cause IMR. Furthermore, increased LV sphericity has been associated with IMR due to incomplete mitral leaflet coaptation assessed as an increased tenting area between the MV leaflets and annulus. A comprehensive pre-cardiopulmonary bypass (CPB) echocardiographic interrogation of IMR begins with a thorough two-dimensional (2D) evaluation to discern the specific mechanism. The degree of leaflet motion restriction, annular dimensions, distance between leaflet coaptation points and septum, anterior and posterior leaflet heights, assessment of regional and global LV function, and localization of regurgitant jet and severity of MV incompetence should all be assessed. In addition, any echocardiographically identifiable risk factors for repair failure should also be identified (2-4). Further delineation of MV pathology and mechanisms associated with IMR may be obtained using 3-D reconstruction or real-time 3D echocardiography (5-10). The Page 2 pre-CPB intraoperative echocardiographic evaluation of IMR must take into consideration the effect of general anesthesia and positive pressure ventilation on the severity of MV incompetence. Other hemodynamic factors including alterations in preload, acute myocardial ischemia, as well as heart rate and rhythm may also be responsible for the dynamic nature of IMR. Ideally, efforts should be made to optimize myocardial performance by administering volume, vasconstrictors, inotropes or even dobutamine stress echocardiography, before a definitive diagnosis which can impact surgical decision-making, can be ascertained (11-13). The initial post-CPB TEE exam is essential in helping to determine MV competency, and begins with an understanding of the surgical procedure that was performed. The almost universally reported benefits of MV repair using an undersized annuloplasty ring support the utility of this technique in the vast majority of patients with IMR. Percutaneous transvenous annuloplasty devices placed in the coronary sinus have also been utilized to reduce the anteriorposterior mitral annulus dimension, improve leaflet co-aptation and reduce IMR severity (14). Furthermore, novel surgical approaches including external LV remodeling by infarct plication (15), external repositioning of the papillary muscles (16), basal chordal cutting (17), and the use of three-dimensional, asymmetrically shaped geometric annular rings (18) have been proposed as potentially more effective strategies to treat IMR. While acute MR present in the immediate post-CPB period may be associated with perivalvular leaks or residual leaflet malcoaptation, the mechanism of recurrent and persistent functional IMR in the chronic phase after surgical annuloplasty may be due to augmented and progressive posterior leaflet tethering (19); anterior leaflet tethering (20), continued left ventricular remodeling (21), as well as other mechanisms. Significant mitral stenosis following MV repair surgery is much less common than persistent MR, and can be more challenging to diagnose. (23-25) Page 3 References 1. Levine RA.Circ.2005;112:745-58 2. Ayanwu A. JASE 2009;22:1265-1268 3. Penicka M. Circ 2009;120:1474-1481 4. Kongsaerepong V.. AJC 2006;98:504-508 5. Abraham T.AJC 1997; 80:1577-1582 6. Jassar A. ATS 2011;91:165-171 7. Vergnat M. ATS 2011; 157-64 8. Watanabe JASE 2006;19:71-75 9. Watanabe. Circ 2005;112:I-458 10. Mahmood F. ATS 2010;90:1212-1220 11. Shiran A. JASE 2007;6:690-7 12. Matyal R. JCVA 2009 ;4 :555-557 13. Banks D. JCVA 2009;4:558-560 14. Webb JG.Circ. 2006;113:851-55 15. Liel-Cohen N, Circ 2000; 101:2756-27636 16. Hung J. Circ 2002; 106:2594-26007 17. Messas E. Circ 2001;104:1958-19638 18. Votta E. ATS 2007;84:92-1019 19. Kuwahara E. Circ 2006;114 (Suppl I):I529-34 20. Lee A. Circ 2009;119:2606-2614 21. Magne J. JASE 2009;22:1256-1564 22. Maslow A, J Cardiothorac Vasc Anesth 2011;25:221-228 23. Poh K. Int J Cardiol 2006;108:177-180, 24. Riegel A, PLOS One 2011;6:e26559