BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Knight-Scott, Jack
Senior MRI Research Associate
eRA COMMONS USER NAME (credential, e.g., agency login)
JK9CNIH
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Eastern Kentucky University
University of Kentucky
Eastern Kentucky University
Medical College of Wisconsin
University of Virginia
BS
BSEE
MS
PhD
PostDoc
05/1986
05/1986
05/1989
01/1997
1996-1999
Physics
Electrical
Nuclear Physics
Biophysics
Radiology- MRI
.
A. Personal Statement
Over the years, I have focused on technology development in spectroscopy as my personal experience was
that the majority of clinical spectroscopy techniques did not yet have the level of sophistication and flexibility
necessary for stable clinical applications. To this end, much of my research interest has been in developing
new techniques, and refining and testing existing spectroscopic techniques. However, several years ago I
reached the conclusion that the best clinical application of in vivo 1H-MRS lies in metabolomic profiling, and so
began to refocus my research towards achieving similar ultra-short echo time (UTE) capabilities in clinical
spectroscopy as was then possible in high-field animal studies. UTE sequences provide the maximum
metabolic information, thus enhancing the possibility of establishing unique metabolic profile for different
diseases, pathologies, and tissue status. Through partnering with Siemens Medical Systems, I have been able
to refine a UTE technique that has been in development for the past five years. The uniqueness of this
technique is that it is currently the only existing UTE sequence that takes advantage of the high SNR offered
by phased-array technology presently available on all clinical 3.0-T MRI systems today (Wijtenburg and KnightScott, JMRI, In Press, and Wijtenburg and Kngiht-Scott, MRI, In Press).
The focus of the current proposal is to explore the relationship between developmental-related changes in
neurochemicals and cognitive development in children, with a long-term goal of applying the information to the
study of neurodevelopmental disorders. To accomplish this, I have assembled an experienced team of
pediatric clinicians/researchers: Susan Palasis, MD, is a pediatric neuroradiologist who uses proton magnetic
resonance spectroscopy clinically on a weekly basis; and Grace Fong, PhD, is a pediatric neuropsychologist
with experience in functional MRI studies. We are first focusing on reading ability as a model of cognitive
development because: 1) the specific brain regions involved are well-established, and 2) reading ability and
skill are strong developmental processes with strong age delineation, particularly at the younger ages. This
study is particularly unique in that it will represent one of the first to employ an ultra-short echo time (UTE)
spectroscopic technique in a clinical study. Also by specifically focusing on development itself, this work can be
ground breaking in demonstrating detectable metabolic correlates of neurodevelopment in the adolescent
brain. Due to our unique combination of capability, technology, and personnel, Children’s Healthcare of Atlanta
is probably one of the few sites in the United States with the means to implement this study.
B. Positions and Honors.
Positions and Employment
1986-1987
Inspection/Test Engineer, Texas Instruments, Dallas, Texas.
1987-1989
Research and Teaching Assistant, Eastern Kentucky University, Richmond, Kentucky.
1989
Test Engineer, GTE TestMark Labs, Lexington, Kentucky.
1989-1991
Visiting Instructor, Eastern Kentucky University, Richmond, Kentucky.
1991-1996
1996-1999
1999-2006
2006-present
Research Assistant, Medical College of Wisconsin, Milwaukee, Wisconsin.
Instructor of Research in Radiology, University of Virginia, Charlottesville, Virginia.
Assistant Professor of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
MRI Research Scientist in Radiology, Children’s Healthcare of Atlanta, Atlanta, Georgia.
Other Experience and Professional Memberships
United States Army Reserves. Honorable Discharge in 1989. Rank: Sergeant
International Society for Magnetic Resonance in Medicine (ISMRM)
American Association for the Advancement of Science (AAAS)
Organization for Human Brain Mapping (OHBM)
Honors
2006
1999
1996-97,99
1995
1992-1996
1991-1992
1987-1989
1984-1986
1982
ISMRM Poster Award Finalist
The Kerrie Exely Hinckley Memorial Award
ISMRM Student Stipend
Medical College of Wisconsin Student Travel Award
National Cancer Institute Minority Research Supplement
Medical College of Wisconsin Graduate Student Fellowship
Eastern Kentucky University Graduate Student Fellowship
ALCOA Minority Scholarship
Allen Foundation Pre-Engineering Scholarship
C. Selected Publications
Original Articles (limited to 15):
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Knight-Scott J, Li S-J. Effect of long TE on T1 measurement in STEAM progressive saturation
experiment. J Magn Reson. 1997. 126:266-69.
Knight-Scott J. Application of multiple inversion recovery for suppression of macromolecule
resonances in short echo time 1H NMR spectroscopy of human brain. J Magn Reson. 1999. 140: 22834.
Keilholz-George SD, Knight-Scott J, Berr SS. A theoretical analysis of the effect of imperfect slice
profiles on tagging schemes for pulsed arterial spin labeling MRI. Magn Reson Med. 2001. 46: 141-48.
Keilholz-George SD, Knight-Scott J, Christopher JM, Mai VM, Berr SS. Gravity-dependent perfusion
of the lung demonstrated with the FAIRER arterial spin tagging method. Magn Reson Imag. 2001. 19:
929-35.
Knight-Scott J, Keilholz-George S, Mai VM, Christopher JM. Temporal dynamics of blood flow effects
in half-fourier fast spin echo 1H magnetic resonance imaging of the human lungs. J Magn Reson Imag.
2001. 14: 411-18.
Knight-Scott J, Farace E, Simnad VI, Siragy HM, Manning CA. Constrained modeling for
spectroscopic measurement of bi-exponential spin-lattice relaxation of water in vivo. Magn Reson Imag
Knight-Scott J, Haley AP, Rossmiller SR, Farace E, Mai VM, Christopher JM, Manning CA, Simnad
VI, Siragy HM. Molality as a unit of measure for expressing 1H MRS brain metabolite concentrations in
vivo. Magn Reson Imag. 2003. 21:787-797.
Haley AP, Knight-Scott J, Fuchs KL, Simnad VI, Manning CA. Shortening of hippocampal T2
relaxation time in Alzheimer's disease: A 1H magnetic resonance spectroscopy study. Neuroscience
Letter. 2004. 362:167-170.
Knight-Scott J, Dunham SA, Shanbhag DD. Increasing the speed of relaxometry-based
compartmental analysis experiments in STEAM spectroscopy. J Magn Reson. 2005. 173:169-174.
Knight-Scott J, Shanbhag DD, Dunham SA. A phase rotation scheme for achieving very short echo
times with localized stimulated echo spectroscopy. Magn Reson Imag. 2005. 23: 871-876.
11.
12.
13.
14.
Haley AP, Knight-Scott J, Simnad VI, Manning CA. Increased glucose concentration in the
hippocampus in early Alzheimer’s disease following oral glucose ingestion. Magn Reson Imag. 2006.
24: 715-720.
Shanbhag DD, Altes TA, Miller GW, Mata JA, Knight-Scott J. Q-space analysis of lung morphometry
in vivo with hyperpolarized 3He spectroscopy. J Magn Reson Imag. 2006. 24: 84-94.
Wijtenburg SA, Knight-Scott J. Reconstructing Very Short TE Phase Rotation Spectral Data Collected
with Multi-Channel Phased-Array Coils at 3-T. Magn Reson Imag. 2011. In Press.
Wijtenburg SA, Knight-Scott J. A Very Short Echo Time Improves the Precision of Glutamate
Detection at 3T in 1H Magnetic Resonance Spectroscopy. J Magn Reson Imag. 2011. In Press
D. Research Support.
Current Research:
2009-present Jack Knight-Scott, Ph.D, PI. Department of Radiology, Children’s Healthcare of Atlanta.
The Expert Spectroscopy System. Sponsor: Siemens Medical Systems, Erlangen, Germany.
Completed Research:
2004-07
Carol Manning, Ph.D, PI. Department of Neurology, University of Virginia Health System.
Changes in Brain Biochemical Activity and Cognition in Mild Cognitive Impairment. Sponsor:
University of Virginia Institute on Aging.
Co-investigator: Jack Knight-Scott, Ph.D.
2005-06
Jack Knight-Scott, Ph.D, PI. Department of Biomedical Engineering, University of Virginia
Health System. Quantitation of age-related changes in cerebral water content. Sponsor:
University of Virginia Institute on Aging.
2008-10
Jack Knight-Scott, Ph.D, PI. Department of Radiology, Children’s Healthcare of Atlanta.
In Vivo Identification of Neural Progenitor Cells and Related Neurogenesis in the Pediatric
Brain. Sponsor: Children’s Healthcare of Atlanta Radiology Research Fund.
2009-11
Jack Knight-Scott, Ph.D, PI. Department of Radiology, Children’s Healthcare of Atlanta.
Phase Rotation of Radiofrequency Pulses in Super-Short Echo Time Spectroscopy: Improving
Localization in the Frontal Lobe. Sponsor: Siemens Medical Systems, Erlangen, Germany.