Curriculum Vitae
Name:
Born:
E-mail:
Anita Solhaug
12.06.74, Tønsberg, Norway
anita.solhaug@vetinst.no
Education/Jobs:
2008-per date Post.Doc in toxicology. Norwegian Veterinary Institute, Oslo. Project:
Toxicological characterization of selected secondary fungal metabolites in Norwegian grain.
Included 4 months in Dr. James Peska`s lab at Michigan State University, USA (2009) and 1
week in Dr. Dominique Lagadic-Gossman`s lab in Rennes, France (2011).
2008, 2009: (7 months total) Guest researcher at Nordic Institute of Dental Materials (NIOM),
Haslum, Norway. Project: Biological effects of leachables from polymer based restorative
materials.
2005-2008. Post.Doc in cell biology. University Hospital, Oslo, Norway. Project: Cellular
responses to targeted genomic sequence modification using single-stranded oligonucleotides and zincfinger nucleases.
2000-2005: Dr.Scient in toxicology. Norwegian Institute of Public Health, Oslo, Norway.
Thesis: Mechanisms involved in PAH-/CP-PAH-induced apoptosis.
1998-2000: Cand.Scient in biotechnology; NTNU, Trondheim, Norway. Thesis:
Phospholipase A2s role and regulation in IL-1-/TNF- induced activation of transcription
factor NF-B
1995-1998 Cand.Mag in biotechnology; University in Trondheim (AVH)/Norwegian
University of Science and Technology (NTNU), Trondheim, Norway.
1994-1995 Biology and chemistry; Sogn & Fjordane University College, Sogndal, Norway
Supervisor and other academicals activities:
Co-supervisor for an apprentice (2001-2003), joint responsibility for work tasks to an
engineer (2001-2003), joint responsibility for organising of semester tasks for students from
UiO (2001-2004), joint supervisor for two master students in toxicology from UiO 2009-2011
and 2011-2013. Secretary of the local division of Norwegian Biochemical Society (NBS),
Biochemical interest group BIG, (2002-2003). Board member in Norwegian flow cytometri
association 2009- per date. Attendance of several national and international meetings with
poster presentation (Society of Toxicology, Nashville, USA, 2002; Apoptosis, Luxembourg,
2003; NBS winter meeting, Norway 1999 and 2003; NordTox, Norway 2001, Gordon
conference, mycotoxins and phycotoxins 2009 NH, USA). Attendance at FEBS-EMBO
advanced lecture course in Molecular Mechanisms in Signal Transduction, Greece, 18-29
2003 and Gordon conference Satelite workshop; Early warning and integrated management of
natural toxin events, ME, USA 2009.
Publications:
1.
Ansteinson V1; Solhaug A1; Samuelsen J.T; Holme JA; Dahl J.E. DNA damage, cellcycle arrest and apoptosis induced in BEAS-2B cells by 2-hydroxyethyl methacrylate
(HEMA). Mutat Res. 2011. In press. 1Both authors contributed equally to this work
2.
Landvik, N. E.; Arlt, V. M.; Nagy, E.; Solhaug, A.; Tekpli, X.; Schmeiser, H. H.;
Refsnes, M.; Phillips, D. H.; Lagadic-Gossmann, D.; Holme, J. A. 3-Nitrobenzanthrone and
3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells. Mutat.
Res. 2010, 684 (1-2), 11-23.
3.
Rakkestad, K. E.; Skaar, I.; Ansteinsson, V. E.; Solhaug, A.; Holme, J. A.; Pestka, J.
J.; Samuelsen, J. T.; Dahlman, H. J.; Hongslo, J. K.; Becher, R. DNA damage and DNA
damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys
chartarum or Aspergillus versicolor or to T-2 toxin. Toxicol. Sci. 2010, 115 (1), 140-155.
4.
Asare, N.; Tekpli, X.; Rissel, M.; Solhaug, A.; Landvik, N.; Lecureur, V.; Podechard,
N.; Brunborg, G.; Lag, M.; Lagadic-Gossmann, D.; Holme, J. A. Signalling pathways
involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death
in Hepa1c1c7 cells. Mutagenesis 2009, 24 (6), 481-493.
5.
Olsen PA.1, Solhaug A1., Booth JA., Gelazauskaite M., Krauss S. Cellular responses
to targeted genomic sequence modification using single-stranded oligonucleotides and zincfinger nucleases. DNA repair. Dec 2008. 1Both authors contributed equally to this work
6.
Laurence Huc, Xavier Tekpli, Jørn A. Holme, Mary Rissel, Anita Solhaug, Claire
Gardyn, Gwénaelle Le Moigne, Morgane Gorria, Marie-Terese Dimanche-Boitrel and
Dominique Lagadic-Grossman. c-Jun NH2-terminal kinase-related Na+/H+ exchanger
isoform 1 activation controls hexokinase II expression in B[a]P-induced apoptosis. Cancer
Research. 2007 Feb 15; 67 (4) :1696-705.
7.
Jørn A. Holme, Morgane Gorria, Volker M. Arlt, Steinar Øvrebø, Anita Solhaug,
Xavier Tekpli, Nina E. Landvik, Laurence Huc, Olivier Fardel, Dominique LagadicGossmann. Different mechanisms involved in apoptosis following exposure to
benzo[a]pyrene in F258 and Hepa1c1c7 cells. Chem Biol Interact. 2007 Jan 17
8.
Nina E. Landvik, Morgane Gorria, Volker M. Arlt, Nana Asare, Anita Solhaug,
Dominique Lagadic-Gossmann, Jørn A. Holme. Effects of nitrated-polycyclic aromatic
hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis:
Possible implications for their mutagenic and carcinogenic effects. Toxicology. 2007 Mar
7;231(2-3):159-74.
9.
Laurence Huc, Mary Rissel, Anita Solhaug, Xavier Tekpli, Morgane Gorria, Alicia
Torriglia, Jørn A. Holme, Marie-Terese Dimanche-Boitrel and Dominique LagadicGrossman. Multiple Apoptotic Pathways Induced by p53-Dependent Acidification in
Benzo[a]pyrene-Exposed Hepatic F258 Cells. Journal of cellular physiology. 2006. 208:527–
537.
10.
Solhaug A, Øvrebø S, Steen Mollerup, Låg M, Schwarze PE, Nesnow S and Holme
JA. Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of
cell signaling inhibitors and apoptotic effects of B[a]P metabolites. Chem Biol Interact. 2005
Jan 15;151(2):101-19.
11.
Solhaug A, Refsnes M and Holme JA. The role of cell signalling involved in
induction of apoptosis by benzo[a]pyrene and cyclopenta[c,d]pyrene in Hepa1c1c7 cells. J
Cell Biochem. 2004 Dec 15;93(6):1143-54.
12.
Solhaug A, Refsnes M, Låg M, Schwarze PE, Husøy T and Holme JA. Polycyclic
aromatic hydrocarbons induce both apoptotic as well as anti-apoptotic signals in Hepa1c1c7
cells. Carcinogenesis. 2004 May;25(5):809-19
13.
Anthonsen MW, Andersen S, Solhaug A, Johansen B. Atypical lambda/iota PKC
conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s
regulating NF-kappa B activation in response to tumor necrosis factor-alpha and interleukin1beta. J Biol Chem. 2001 Sep 21;276(38):35344-51.
14.
Anthonsen MW, Solhaug A, Johansen B. Functional coupling between secretory and
cytosolic phospholipase A2 modulates tumor necrosis factor-alpha- and interleukin-1betainduced NF-kappa B activation. J Biol Chem. 2001 Aug 10;276(32):30527-36.