研究業績
2005 年
1. Kosugi N, Ebihara Y, Nakahata T, Saisho H, Asano S, Tojo A: CD34+CD7+ leukemic progenitor cells
may be involved in maintenance and clonal evolution of chronic myeloid leukemia. Clin Cancer Res.
11:505-11, 2005
2004 年
1. Tsuchimoto D, Tojo A, Asano S: A mechanism of transcriptional regulation of the CSF-1 gene
by interferon-gamma. Immunol Invest. 33:397-405, 2004
2. Cho SG, Shuto Y, Soda Y, Nakazaki Y, Izawa K, Uchimaru K, Takahashi S, Tani K, Tojo A, Asano S:
Anti-NK cell treatment induces stable mixed chimerism in MHC-mismatched, T-cell depleted,
nonmyeloablative bone marrow transplantation. Exp Hematol. 32:1246-54, 2004
3. Tani K, Azuma M, Nakazaki Y, Oyaizu N, Hase H, Ohata J, Takahashi K, OiwaMonna M, Hanazawa K,
Wakumoto Y, Kawai K, Noguchi M, Soda Y, Kunisaki K, Watari K, Takahashi S, Machida U, Satoh N,
Tojo A, Maekawa T, Eriguchi M, Tomikawa S, Tahara H, Inoue Y, Yoshikawa H, Yamada Y, Iwamoto A,
Hamada H, Yamashita N, Okumura K, Kakizoe T, Akaza H, Fujime M, Clift S, Ando D, Mulligan R,
Asano S: Phase I Study of Autologous Tumor Vaccines Transduced with the GM-CSF Gene in Four
Patients with Stage IV Renal Cell Cancer in Japan: Clinical and Immunological Findings. Mol Ther.
10:799-816, 2004
4. Izawa K, Tani K, Nakazaki Y, Hibino H, Sugiyama H, Kawasaki A, Sasaki E, Nishioka C, Ishii H, Soda
Y, Yagita H, Tanioka Y, Tojo A, Asano S: Hematopoietic ativity of common marmoset CD34+ cells by a
novel monoclonal antibody MA24. Exp Hematol. 32:843-51, 2004
5. Harata M, Soda Y, Tani K, Ooi J, Takizawa T, Chen M, Bai Y, Izawa K, Kobayashi S, Tomonari A,
Nagamura F, Takahashi S, Uchimaru K, Iseki T, Tsuji T, Takahashi TA, Sugita K, Nakazawa S, Tojo A,
Maruyama K, Asano S: CD19-targeting liposomes containing imatinib efficiently kill Philadelphia
chromosome-positive acute lymphoblastic leukemia cells. Blood. 104:1442-9, 2004
6. Soda Y, Tani K, Bai Y, Saiki M, Chen M, Izawa K, Kobayashi S, Takahashi S, Uchimaru K, Kuwabara T,
Warashina M, Tanabe T, Miyoshi H, Sugita K, Nakazawa S, Tojo A, Taira K, Asano S: A novel
maxizyme vector targeting a bcr-abl fusion gene induced specific cell death in Philadelphia
chromosome-positive acute lymphoblastic leukemia. Blood. 104:356-63, 2004
7. Oshima Y, Tojo A, Fujimua A, Niho Y, Asano S: Potent receptor-mediated cytotoxicity of granulocyte
colony-stimulating factor-Pseudomonas exotoxin A fusion protein against myeloid leukemia cells.
Biochem Biophys Res Commun. 319:582-9, 2004
8
Morishita M, Uchimaru K, Sato K, Yamashita S, Kanematsu T, Yamashita N, Thyroglobulin-pulsed
human monocyte-derived dendritic cells induce CD4+T cell activation. Int J Mol Med. 13:33-9, 2004
9
Kobayashi S, Kaneko Y, Seino K, Yamada Y, Motohashi Y, Koike J, Sugaya K, Kuriyama T, Asano S,
Tsuda T, Wakao H, Harada M, Kojo S, Nakayama T, Taniguchi M. Impaired IFN-γ production of Vα24
NKT cells in non-remitting sarcoidosis. Int Immunol. 16:215-22, 2004
2003 年
1.
Nagamura F, Takahashi T, Takeuchi M, Iseki T, Ooi J, Tomonari A, Uchimaru K, Takahashi S, Tojo A,
Tani K, Asano S: Effect of cyclophosphamide on serum cyclosporine levels at the conditioning of
hematopoietic stem cell transplantation. Bone Marrow Transplant. 32:1051-8, 2003
2.
Zheng Y, Watanabe N, Nagamura-Inoue T, Igura K, Nagayama H, Tojo A, Tanosaki R, Takaue Y,
Okamoto S, Takahashi T.A: Ex vivo manipulation of umbilical cord-derived hematopoietic
stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of
homing-essential molecules to increase their transmigratory potential. Exp Hematol. 31:1237-46, 2003
3.
Bai Y, Soda Y, Izawa K, Tanabe T, Kang X, Tojo A, Hoshino H, Miyoshi H, Asano S, Tani K: Effective
transduction and stable transgene expression in human blood cells by a third-generation lentiviral
vector. Gene Therapy. 10:1446-57. 2003
4.
Nagayama H, Sato K, Morishita M, Uchimaru K, Oyaizu N, Inazawa T, Yamasaki T, Enomoto M,
Nakaoka T, Nakamura T, Maekawa T, Yamamoto A, Shimada S, Saida T, Kawakami Y, Asano S, Tani
K, Takahashi TA, Yamashita N:
Results of phase I clinical study using autologous tumor-lysate
pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients
combined with low dose interleukin-2. Melanoma Res. 13:1-10, 2003
5.
Takahashi S, Mok H, Parrott MB, Marini FC, Andreef M, Brenner MK, Barry MA. Selection of
chronic lymphocytic leukemia (CLL) binding peptides.
6.
Cancer Res. 63:5213-7, 2003
Oshima K, Kawasaki H, Soda Y, Tani K, Asano S, Taira K: Maxizyme and small hairpin-type RNAs
that are driven by a tRNA promoter specifically cleaves a chimeric gene associated with leukemia in
vitro and in vivo. Cancer Res. 63:6809-14, 2003
7.
Biagi E, Yvon E, Dotti G, Amrolia PJ, Takahashi S, DeSombre C, Popat U, MD, Rice L, Marini F,
Andreeff M, Brenner MK, Rousseau RF. Induction of Functional Human CD40 Ligand (hCD40L)
Expression on B-Chronic Lymphocytic Leukemia Cells. Hum Gene Ther. 14:545-59, 2003.
2002 年
1.
Iijima Y, Okuda K, Tojo A, Tri NK, Setoyama M, Sakaki Y, Asano S, Tokunaga K, Kruh GD, Sato Y:
Transformation of Ba/F3 cells and Rat-1 cells by ETV6/ARG. Oncogene. 21:4374-83, 2002
2.
Motohashi S, Kobayashi S, Ito T, Magara KK, Mikuni O, Kamada N, Iizasa T, Nakayama T,
Fujisawa T, Taniguchi M: Preserved interferon- production of circulating V24 NKT cells in
primary lung cancer. Int J Cancer. 102:159-65, 2002
3.
Ohata J, Sakurai J, Saito K, Tani K, Asano S, Azuma M: Differential graft-versus-leukemia effect by
CD28 and CD40 co-stimulatory blockade after graft-versus-host disease prophylaxis.
Clin Exp
Immunol. 129: 61-8, 2002
2001 年
1.
Hibino H, Tani K, Sugiyama H, Suzuki S, Wu M-S, Izawa K, Hase H, Nakazaki Y, Tanabe T, Ooi J,
Iseki T, Tojo A, Saitoh I, Tanioka Y, Asano S: Haematopoietic progenitor cells from the common
marmoset as targets of gene transduction by retroviral and adenoviral vectors. Eur J Haematol. 66:
272-80, 2001
2.
Rousseau RF, Hirschmann-Jax C, Takahashi S, Brenner MK. Cancer vaccine. Hematology/Oncology
Clinics of North America. 154:741-73, 2001.
3.
Dotti G, Savoldo B, Takahashi S, Goltsova T, Rill D, Rooney C, Brennser M: Adenovector induced
expression of human-CD40L by multiple myeloma cells: a model for immunotherapy. Exp Hematol.
29:952–61, 2001.
4.
Takahashi S, Yotnda P, Rousseau RF, Mei Z, Smith S, Rill D, Youne A, Brenner MK: Transgenic
expression of CD40L and Interleukin–2 induces an autologous anti-tumor immune response in patients
with non-Hodgkin lymphoma. Cancer Gene Ther. 8:378-87, 2001.
5.
Takahashi S, Rousseau RF, Yotnda P, Mei Z, Dotti G, Rill D, Hurwitz R, Marini F, Andreeff M, Brenner
MK. Autologous antileukemic immune responses induced by chronic lymphocytic leukemia B cells
expressing the CD40 ligand and interleukin-2 transgenes. Hum Gene Ther. 12:659-70, 2001.
2000 年
1.
Wu M-S, Tani K, Sugiyama H, Hibino H, Izawa K, Tanabe T, Nakazaki Y, Ishii H, Ohashi J, Hohjoh H,
Iseki T, Tojo A, Nakamura Y, Tanioka Y, Tokunaga K, Asano S: MHC (Major Histocompatibility
Complex)-DRB Genes and polymorphisms in common marmoset. J Mol Evol. 51:214-22, 2000
2.
Watari K, Tojo A, Nagamura-Inoue T, Matsuoka M, Irie S, Tani K, Yamada Y, and Asano S:
Hyperfunction of neutrophils in a BCR/ABL-negative chronic myeloid leukemia: A case report with in
vitro studies. Cancer. 89:551-6, 2000
3.
Hase H, Tani K, Nagayama H, Watari K, Takahashi S, Ooi J, Shirafuji N, Iseki T, Nakazaki Y,
Yamashita T, Nakamura T, Masunaga A, Maekawa T, Tojo A, Asano S: TCR-V repertoire analysis
with RT-PCR was useful for the early detection of pulmonary relapsed T cell lymphoma after
autologous peripheral blood stem cell transplantation. Am J Hematol. 64:124-7, 2000
4.
Machida U, Tojo A, Takahashi S, Iseki T, Ooi J, Nagayama H, Shirafuji N, Mori S-I, Wada Y, Ogami
K, Yamada Y, Sakamaki H, Maekawa T, Tani K, Asano S: The effect of G-CSF administration in
healthy donors before bone marow harvesting. Br J Haematol. 108:747-53, 2000
5.
Kosugi N, Tojo A, Shinzaki H, Nagamura-Inoue T, Asano S: The preferential expression of CD34 and
CD7 in myeloid blast crisis in chronic myeloid leukemia. Blood. 95:2188-9, 2000
6.
Watari K, Tojo A, Nagamura-Inoue T, Nagamura F, Takeshita A, Fukushima T, Motoji T, Tani K, Asano
S: Identification of a melanoma antigen, PRAME, as a BCR-ABL-inducible gene. FEBS Letters.
466:367-71, 2000
7.
Oshima Y, Tojo A, Niho Y, Asano S: Biological activity of human granulocyte colony-stimulating
factor with a modified C-terminus. Biochem Biophys Res Commun. 267:924-7, 2000
8.
Tanabe T, Kuwabara T, Warashima M, Tani K, Taira K, Asano S: Oncogene inactivation in a mouse
model: tissue invasion by leukemic cells is stalled by loading them with a designer ribozyme. Nature.
406:473-4, 2000
9.
Soda Y, Jinno A, Tanaka Y, Akagi T, Shimotohno K, Hoshino H: Rapid tumor formation and
development of neutropenia and splenomegaly in nude mice transplanted with human cells expressing
human T cell leukemia virus type I or Tax1. Leukemia. 14:1467-76, 2000