Last data updates: 06 January 2011
Tang, X.Q., Wang, Y., Huang, Z.H., Han, J.S. and Wan, Y. (2004), Adenovirus-mediated delivery
of GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with
spinal cord injury. Neuroreport, 15 (3), 425-429.
Document type: Article Language: English Cited references: 15 Time cited: 13 Times self cited: 0
Abstract: The aim of the present study was to assess the effect of glial cell line-derived neurotrophic
factor (GDNF) delivery mediated by a recombinant adenovirus (AdCMVgdnf or AdCMVlacZ) on
the functional recovery and central neuronal atrophy in adult rats with spinal cord injury. Bilateral
electrolytic lesions were made in the corticospinal tracts at the T10 vertebral level in a rat model.
AdCMVgdnf or AdCMVlacZ was injected at the lesion site immediately after operation. After 2-3
weeks the neurological score and the inclined plane angle were significantly higher and the soma
size of corticospinal motoneurons was larger in the AdCMVgdnf group compared with the
AdCMVlacZ group. These results demonstrated that adenovirus-mediated delivery of GDNF could
prevent the retrograde atrophy of corticospinal motoneurons and improve the motor function in rats
with spinal cord injury.
Author Keywords: adenovirus; corticospinal motoneuron; GDNF; gene therapy; spinal cord injury
Keywords Plus: Neurotrophic Factor; Gene-Expression; Survival; Transplants; Motoneurons; Pcr
Reprint Address: Wan, Y (reprint author), Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Neurosci Res
Inst, 38 Xueyuan Rd, Beijing 100083, Peoples R China
Addresses:
1. Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Neurosci Res Inst, Beijing 100083, Peoples R China
E-mail Addresses: ywan@bjmu.edu.cn
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