生化暨分子生物
科
師資陣容
教師姓名
English Name
職稱
Title
畢業學校
School
學位
Degree
畢業年次
Year of graduation
研究領域
Research Topic
近五年發表
吳明道
實驗室分機
5176
實驗室位置
第一醫學大樓 9 樓
Albert M. Wu
教授
Professor
（一）國立台灣大學
（二）美國紐約醫學院
（一）National Taiwan University
（二）New York Medical college, USA
（一）理學士
（二）博士
（一）B.S.
（二）Ph.D
（一）1965
（二）1975
（一）1965
（二）1975
1. 複雜性碳水化合物
2. 凝集素學
3. 醣類分子免疫學
4. 醣類生物學
1. Complex Carbohydrates
2. Lectinology
3. Glyco-molecular Immunology
4. Glycobiology
1.
Wu AM, Carbohydrate structural units in glycosphingolipids as receptors for
Gal and GalNAc reactive lectins. Neurochem. Res. 27(7-8):593-600, 2002,
Review.
2.
Wu AM, Wu JH, Tsai MS, Liu JH, Andre S, Wasano K, Kaltner H, Gabius
HJ, Fine specificity of domain-I of recombinant tandem-repeat-type
galectin-4 from rat gastrointestinal tract (G4-N). Biochem. J. 367(Pt
3):653-64, 2002.
3.
Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S,
Wu AM, Gilboa-Garber N, Imberty A, Structural basis for
oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs
of cystic fibrosis patients. Nat Struct Biol. 9(12):918-21, 2002.
4.
Wu AM, Wu JH, Lin LH, Lin SH, Liu JH, Binding profile of Artocarpus
integrifolia agglutinin (Jacalin).Life Sci. 72(20):2285-302, 2003.
5.
Wu AM, Wu JH, Herp A, Liu JH, Effect of polyvalencies of glycotopes on
the binding of a lectin from the edible mushroom, Agaricus bisporus.
Biochem. J. 371(Pt 2):311-20, 2003.
6.
Wu AM, Carbohydrate structural units in glycoproteins and polysaccharides
as important ligands for Gal and GalNAc reactive lectins. J. Biomed. Sci.
10(6 Pt 2):676-88, 2003, Review.
7.
Wu AM, Wu JH, Liu JH, Singh T, Recognition profile of Bauhinia purpurea
agglutinin (BPA). Life Sci. 74(14):1763-79, 2004.
8.
Wu AM, Wu JH, Liu JH, Singh T, Andre S, Kaltner H, Gabius HJ, Effects of
polyvalency of glycotopes and natural modifications of human blood group
ABH/Lewis sugars at the Galbeta1-terminated core saccharides on the
binding of domain-I of recombinant tandem-repeat-type galectin-4 from rat
gastrointestinal tract (G4-N). Biochimie. 86(4-5):317-26, 2004.
9.
Wu AM, Wu JH, Singh T, Liu JH, Herp A, Lectinochemical studies on the
affinity of Anguilla anguilla agglutinin for mammalian glycotopes. Life Sci.
75(9):1085-103, 2004.
10. Wu AM, Wu JH, Singh T, Chu KC, Peumans WJ, Rouge P, Van Damme EJ,
A novel lectin (Morniga M) from mulberry (Morus nigra) bark recognizes
oligomannosyl residues in N-glycans. J. Biomed. Sci. 11(6):874-85, 2004.
11. Wu AM, Polyvalent GalNAcalpha1 → Ser/Thr (Tn) and Galbeta1 →
3GalNAcalpha1→Ser/Thr (T alpha) as the most potent recognition factors
involved in Maclura pomifera agglutinin-glycan interactions. J. Biomed.
Sci. 12(1):135-52, 2005.
12. Wu AM, Wu JH, Kuo HW, Herp A, Further characterization of the binding
properties of two monoclonal antibodies recognizing human Tn red blood
cells. J. Biomed. Sci. 12(1):153-66, 2005.
13. Wu AM, Lectinochemical studies on the glyco-recognition factors of a Tn
(GalNAcalpha1→Ser/Thr) specific lectin isolated from the seeds of Salvia
sclarea. J. Biomed. Sci. 12(1):167-84, 2005.
14. Singh T, Chatterjee U, Wu JH, Chatterjee BP, Wu AM, Carbohydrate
recognition factors of a Talpha (Galbeta1→3GalNAcalpha1→Ser/Thr) and
Tn (GalNAcalpha1→Ser/Thr) specific lectin isolated from the seeds of
Artocarpus lakoocha. Glycobiology. 15(1):67-78, 2005.
近五年發表
15. Wu AM, Wu JH, Singh T, Hwang PY, Tsai MS, Herp A, Lectinochemical
studies on the binding properties of a toxic lectin (ricin) isolated from the
seeds of Ricinus communis. Chang Gung Med. J. 28(8):530-42, 2005.
16. Singh T, Wu JH, Peumans WJ, Rouge P, Van Damme EJ, Alvarez RA, Blixt
O, Wu AM, Carbohydrate specificity of an insecticidal lectin isolated from
the leaves of Glechoma hederacea (ground ivy) towards mammalian
glycoconjugates. Biochem. J. 393(Pt 1):331-41, 2006.
17. Wu JH, Singh T, Herp A, Wu AM, Carbohydrate recognition factors of the
lectin domains present in the Ricinus communis toxic protein (ricin).
Biochimie. 88(2):201-17, 2006.
18. Wu AM, Wu JH, Singh T, Lai LJ, Yang Z, Herp A, Recognition factors of
Ricinus communis agglutinin 1 (RCA(1)).Mol. Immunol. 43(10):1700-15,
2006.
19. Wu WC, Lai CC, Liu JH, Singh T, Li LM, Peumans WJ, Van Damme EJ,
Wu AM, Differential binding to glycotopes among the layers of three
mammalian retinal neurons by man-containing N-linked glycan, T(alpha)
(Galbeta1-3GalNAcalpha1-), Tn (GalNAcalpha1-Ser/Thr) and I (beta)/II
(beta) (Galbeta1-3/4GlcNAcbeta-) reactive lectins. Neurochem. Res.
31(5):619-28, 2006.
20. Wu AM, Singh T, Wu JH, Lensch M, Andre S, Gabius HJ, Interaction
profile of galectin-5 with free saccharides and mammalian glycoproteins:
probing its fine specificity and the effect of naturally clustered ligand
presentation. Glycobiology. 16(6):524-37, 2006.
21. Wu AM, Wu JH, Singh T, Liu JH, Tsai MS, Gilboa-Garber N, Interactions
of the fucose-specific Pseudomonas aeruginosa lectin, PA-IIL, with
mammalian glycoconjugates bearing polyvalent Lewis(a) and ABH blood
group glycotopes. Biochimie. 88(10):1479-92, 2006.
22. Singh T, Wu JH, Peumans WJ, Rouge P, Van Damme EJ, Wu AM,
Recognition profile of Morus nigra agglutinin (Morniga G) expressed by
monomeric ligands, simple clusters and mammalian polyvalent glycotopes.
Mol. Immunol. 44(4):451-62, 2007.
23. Wu AM, Singh T, Liu JH, Krzeminski M, Russwurm R, Siebert HC, Bonvin
AM, Andre S, Gabius HJ, Activity-structure correlations in divergent lectin
evolution: fine specificity of chicken galectin CG-14 and computational
analysis of flexible ligand docking for CG-14 and the closely related CG-16.
Glycobiology. 17(2):165-84, 2007.
近五年發表
24. Wu AM, Wu JH, Tsai MS, Yang Z, Sharon N, Herp A, Differential affinities
of Erythrina cristagalli lectin (ECL) toward monosaccharides and
polyvalent mammalian structural units. Glycoconjugate J. (accepted), 2007.
25. Wu AM, Khoo KH, Yu SY, Yang Z, Kannagi R, Watkins WM, Glycomic
Mapping of Pseudomucinous Human Ovarian Cyst Glycoproteins:
Identification of Lewis and Sialyl Lewis Glycotopes. Proteomics (accepted),
2007.
26. Yu SY, Khoo KH, Yang Z , Herp A, Wu AM, Glycomic Mapping of O- and
N-linked Glycans from Major Rat Sublingual Mucin. Glycoconjugate J.
(accepted), 2007.