DR DAVID J ATHERTON: PRINCIPAL PUBLICATIONS Books: Atherton David J Your child with eczema – a guide for parents London: Heinemann Medical 1984 Atherton David J Eczema in Childhood - The Facts Oxford: Oxford Medical Publ 1994 Chapters in Books: Atherton DJ, Wells RS. Inherited disorders. In: Topics in Paediatric Dermatology. Ed Verbov J. London: Heinemann, 1979: 1-20 Levinsky RJ, Paganelli R, Roberton RM, Atherton DJ. Food antigen absorption and immune complex formation in normal and atopic subjects. In: The Mucosal Immune System. Martinus Nighoff. 1981: 154-72 Levinsky RJ, Paganelli R, Roberton RM, Atherton DJ. Handling of food antigens and their complexes in healthy and allergic individuals. In: Immunological Aspects of Infant Feeding. Ed. Wilkinson AW. Plenum Press. 1981: 2330 Atherton DJ. Atopic eczema. In: Food Allergy. Eds. Brostoff J, Challacombe S. Clinics in Immunology and Allergy 1982; 2(1): 77-100 Atherton DJ. Immunological aspects of skin disease. In: Paediatric Immunology. Eds. Soothill JF, Hayward AR, Wood CBS. Oxford: Blackwell 1983: 393-426 Atherton DJ, Wells RS. Etretinate in the ichthyosiform erythrodermas. In: Retinoid Therapy. Eds. Cunliffe WJ, Miller AJ. Lancaster: MTP Press 1984: 63-71 Horton JJ, Atherton DJ. Razoxane. In: Psoriasis. Eds. Roenigk JR, Maibach HI. New York: Marcel Dekker 1985: 457-63 Pike MG, Atherton DJ. Recent advances in the treatment of atopic eczema. In: Progress in Child Health: Vol. 2, Ed. Macfarlane JA. Edinburgh: Churchill Livingstone 1985: 13-28 Atherton DJ, Rook A. Naevi and other developmental defects. In: A Textbook of Dermatology. Eds. Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL. Oxford: Blackwell 1986: 167-227 Atherton DJ, Rook A. The newborn. In: A Textbook of Dermatology. Eds. Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL. Oxford: Blackwell 1986: 229-64 Pike M, Atherton DJ. Atopic eczema. In: Food Allergy and Intolerance. Eds. Brostoff J, Challacombe SJ. London: Bailliere Tindall 1986: 583-601 Atherton DJ. Dermatological emergencies. In: Paediatric Emergencies. Ed. Black JA. London: Butterworth 1987: 503-18 Atherton DJ. Food allergy and atopic eczema. In: Food Intolerance. Ed. Dobbing J. London: Bailliere Tindall 1987: 74-83 Atherton DJ. Zinc deficiency In: Handbook of Experimental Pharmacology Vol 87/II: Pharmacology of the Skin. Eds. Greaves MW & Schuster Berlin Heidelberg: Springer-Verlag, 1989: 553-60 Atherton DJ Skin manifestations of food allergy In: Food Intolerance in Infancy, Ed. Hamburger RN. New York: Raven Press 1989: 145-54 Atherton DJ Counselling in epidermolysis bullosa In: Epidermolysis Bullosa, eds Priestley G, Tidman M, Weiss J, Eady R. Crowthorne: DEBRA 1990: 13-7 Atherton DJ Management of the neonate with epidermolysis bullosa In: Epidermolysis Bullosa, eds Priestley G, Tidman M, Weiss J, Eady R. Crowthorne: DEBRA 1990: 33-6 Atherton DJ Systemic therapy of epidermolysis bullosa In: Epidermolysis Bullosa, eds Priestley G, Tidman M, Weiss J, Eady R. Crowthorne: DEBRA 1990: 168-72 Atherton DJ. The neonate. In: Textbook of Dermatology. Eds. Champion RH, Burton JL, Ebling FJG. Oxford: Blackwell Scientific 1992: 381-444 2 Atherton DJ. Naevi and other developmental defects. In: Textbook of Dermatology. Eds. Champion RH, Burton JL, Ebling FJG. Oxford: Blackwell Scientific 1992: 445-526 Atherton DJ. The role of food in atopic dermatitis. In: Paediatric Dermatology: Controversies and Current Concepts, ed. C. Gelmetti, New York: DM Medical Publ. 1994: 14-29 Atherton DJ. The management of anogenital papillomavirus infections. In: Paediatric Dermatology: Controversies and Current Concepts, ed. C. Gelmetti, New York: DM Medical Publ. 1994: 99-128 Atherton DJ Epidermolysis bullosa. In: Inherited Skin Disorders. ed Harper J, Oxford: Butterworth Heinemann, 1996: 53-68 Atherton DJ. Naevi and other developmental defects. In: Textbook of Dermatology. Eds Champion RH et al. Oxford: Blackwell Science. 6th edition 1998: pp 449-518 Atherton DJ. The neonate. In: Textbook of Dermatology. Eds Champion R et al. Oxford: Blackwell Science. 6th edition 1998: pp 519-616 Atherton DJ Epidermolysis bullosa In: Textbook of Pediatric Dermatology eds Harper J, Oranje A, Prose N, 1 st Ed, Oxford, Blackwell Science, 2000: 1075-100 Atherton DJ. An orthodox practitioner’s view of Chinese medicine. In: The Way Forward For Chinese Medicine. Eds Chan K, Lee H. London: Taylor & Francis 1st ed 2002: pp397-411 Gan C, Atherton DJ. Treatment in childhood In: Handbook of Systemic Drug Treatment in Dermatology. Ed. Wakelin SH London: Manson 1st ed 2002: pp223-32 Atherton DJ, Gennery AR, Cant AJ. The Neonate. In: Rook’s Textbook of Dermatology 7 th ed. Eds Burns T, Breathnach S, Cox N, Griffiths C. Oxford: Blackwell Science 2004: pp14.1-87 Atherton DJ, Moss C. Naevi and other developmental defects. In: Rook’s Textbook of Dermatology 7th ed. Eds Burns T, Breathnach S, Cox N, Griffiths C. Oxford: Blackwell Science 2004: pp15.1-113 3 Atherton DJ, Mellerio JE, Denyer JE Epidermolysis bullosa In: Textbook of Pediatric Dermatology eds Harper J, Oranje A, Prose N, 2nd Ed, Oxford, Blackwell Science, 2005: pp1217-1303 Irvine A, Lomas D, Atherton D, Harper J. Dermatology. In: The Great Ormond Street Handbook of Paediatrics and Child Health Eds Strobel S, Marks SD, Smith PK, El Habbal MH, Spitz L. London: Manson 2007, p131-59 Sidwell RU, Atherton DJ Dermatology. In: Easy Paediatrics, eds. Sidwell RU, Thomson MA. London: Hodder & Stoughton. 2011, p287-308 Peer-reviewed papers: Atherton DJ, Sewell M, Soothill JF, Wells RS, Chilvers CED. A double blind controlled cross-over trial of an antigen avoidance diet in atopic eczema. Lancet 1978; i: 401-3 Milla PJ, Atherton DJ, Leonard JV, Wolff OH, Lake BD. Disordered intestinal function in glycogen storage disease. J. Inher. Metab. Disease 1978; 1: 155-7 Atherton DJ, Wells RS. Genital Crohn's disease in a six-year old boy. Brit. Med. J. 1978; 1: 552 Atherton DJ, Muller DPR, Aggett PJ, Harries JT. A defect in zinc uptake by jejunal biopsies in acrodermatitis enteropathica. Clin. Science 1979; 56: 505-7 Atherton DJ, Wells RS, Laurent MR, Williams YF. Razoxane for psoriasis. Brit. J. Dermatol. 1980; 102: 307-17 Aggett PJ, Atherton DJ, Moore J, Davey J, Delves HT, Harries JT. Symptomatic zinc deficiency in a breast-fed preterm infant. Arch. Dis. Child. 1980; 55: 547-50 Atherton DJ, Pitcher D, MacDonald DM, Wells RS. A syndrome of various cutaneous pigmented lesions, myxoid neurofibromata and atrial myxoma - the NAME syndrome. Brit. J. Dermatol. 1980; 103: 421-9 Atherton DJ, Hall M. Focal dermal hypoplasia. Clin. Exp. Dermatol. 1980; 5: 249-52 Atherton DJ, Wells RS. 4 Confluent and reticulate papillomatosis. Clin. Exp. Dermatol. 1980; 5: 465-9 Paganelli R, Levinsky RJ, Atherton DJ. Detection of specific antigen within circulating immune complexes. Validation of the assay and its application to food antigen-antibody complexes found in healthy and in foodallergic subjects. Clin. Exp. Immunol. 1981; 46: 44-53 Aggett PJ, Delves HT, Thorn JM, Atherton DJ, Harries JT, Bangham AD. The therapeutic effect of amphotericin in acrodermatitis enteropathica: hypothesis and implications. Eur. J. Paediat. 1981; 137: 23-5 Atherton DJ. Razoxane. Clin. Exp. Dermatol. 1981; 6: 647-50 Atherton DJ, Wells RS. Juvenile elastoma and osteopoikilosis: the Buschke-Ollendorf syndrome. Clin. Exp. Dermatol. 1982; 7: 109-13 Atherton DJ, Soothill JF, Elvidge MJ. A controlled trial of oral sodium cromoglycate in atopic eczema. Brit. J. Dermatol. 1982; 106: 681-6 Jorizzo JF, Atherton DJ, Crounse RG, Wells RS. Ichthyosis, brittle hair, impaired intelligence, decreased fertility and short stature (IBIDS syndrome). Brit. J. Dermatol. 1982; 106: 705-10 Butler M, Atherton DJ, Levinsky RJ. Quantitative and functional deficit of suppressor T cells in children with atopic eczema. Clin. Exp. Immunol. 1982; 50: 92-8 Paganelli R, Atherton DJ, Levinsky RJ. Differences between normal and milk allergic subjects in their immune responses after milk ingestion. Arch. Dis. Child. 1983; 58: 201-6 Broadbent V, Pritchard J, Davies EG, Levinsky RJ, Heaf D, Atherton DJ, Pincott JR, Tucker S. Spontaneous remission of multisystem histiocytosis X. Lancet 1984; i: 253-4 Lovell CR, Atherton DJ. Infantile gluteal granulomata. Clin. Exp. Dermatol. 1984; 9: 522-5 5 Heddle RJ, Soothill JF, Bulpitt CJ, Atherton DJ. Combined oral and nasal beclomethasone dipropionate in children with atopic eczema: a randomised controlled trial. Brit. Med. J. 1984; 289: 651-4 Tidman MJ, Atherton DJ, Eady RAJ. Squamous cell carcinoma as a complication of dystrophic epidermolysis bullosa. J. Roy. Soc. Med. 1984; 77 Suppl 4: 37-9 Bromberg JEC, Creutzberg CL, Atherton DJ. Sweat production from children's feet. Clin. Exp. Dermatol. 1985; 10: 229-32 Bye AME, Goodfellow A, Atherton DJ. Transient zinc deficiency in a full-term breast-fed infant of normal birth weight. Pediat. Dermatol. 1985; 2: 308-11 Salih MAM, Lake BD, ElHag MA, Atherton DJ. Lethal epidermolytic epidermolysis bullosa: a new autosomal recessive type of epidermolysis bullosa. Brit. J. Dermatol. 1985; 113: 135-43 Pike MG, Heddle RJ, Boulton P, Turner MW, Atherton DJ. Increased intestinal permeability in atopic eczema. J. Invest. Dermatol. 1986: 86: 101-4 Jenkins HR, Walker-Smith JA, Atherton DJ. Protein-losing enteropathy in atopic dermatitis. Pediatr. Dermatol. 1986; 3: 125-9 Pike MG, Baraitser M, Dinwiddie R, Atherton DJ. A distinctive type of hypohidrotic ectodermal dysplasia featuring hypothyroidism. J. Pediatr. 1986; 108: 109-11 Wong E, Holden CA, Broadbent V, Atherton DJ. Histiocytosis X presenting as intertrigo and responding to topical nitrogen mustard. Clin. Exp. Dermatol. 1986; 11: 183-7 Zachary CB, Atherton DJ. Hyper-IgE syndrome. Clin. Exp. Dermatol. 1986; 11: 403-8 Lansdown R, Atherton DJ, Dale A, Sproston S, Lloyd J. Practical and psychological problems for parents of children with epidermolysis bullosa. Child Care, Health and Development 1986; 12: 251-6 Rebello T, Atherton DJ, Holden C. The effects of oral zinc administration on sebum free fatty acids in acne vulgaris. Acta Dermatol. Venereol. (Stockh) 1986; 66: 305-11 6 Glover MT, Peters AM, Atherton DJ. Surveillance for skeletal toxicity of children treated with etretinate. Brit. J. Dermatol. 1987; 116: 609-14 Davies H, Atherton DJ. Acute laryngeal obstruction in junctional epidermolysis bullosa. Pediatr. Dermatol. 1987; 4: 98-101 Glover MT, Atherton DJ. Congenital infection with Herpes simplex virus type I. Pediatr. Dermatol. 1987: 4: 336-40 Glover MT, Atherton DJ, Levinsky RJ. The syndrome of erythroderma, failure to thrive and diarrhoea in infancy: a manifestation of immunodeficiency. Pediatrics 1988; 81: 66-72 Glover MT, Atherton DJ. Transient zinc deficiency in two full-term breast-fed siblings associated with low maternal breast milk zinc concentration. Pediatr. Dermatol. 1988; 5: 10-3 Atherton DJ, Carabott F, Glover MT, Hawk JM. The role of psoralen photochemotherapy (PUVA) in the treatment of severe atopic eczema in adolescents. Brit. J. Dermatol. 1988; 118: 791-5 Kalter DC, Griffiths WA, Atherton DJ Linear and whorled nevoid hypermelanosis. J. Am. Acad. Dermatol. 1988; 19: 1037-44 Pike MG, King GS, Pettit BR, Leonard JV, Atherton DJ Lactulose in trimethylaminuria, the fish-odour syndrome Helv. paediat. Acta. 1988; 43: 345-8 Pike MG, Hammerton M, Edge J, Atherton DJ, Grant DB A family with X-linked ichthyosis and hypogonadism Eur. J. Pediatr. 1989; 148: 442-4 Atherton DJ, Botcherby PK, Francis AJ, Smith NP, Wells RS, Giannelli F. Familial keratoses of actinic distribution associated with internal malignancy and cellular hypersensitivity to UVA. Brit. J. Dermatol. 1989; 120: 671-81 Pike MG, Riches P, Atherton DJ. Fecal alpha-1 antitrypsin concentration and gastrointestinal permeability to oligosaccharides in atopic dermatitis. Pediatr. Dermatol. 1989; 6: 10-2 Atherton DJ, Kahana M, Russell-Jones R 7 Naevoid psoriasis Brit. J. Dermatol. 1989; 120: 837-41 Clayton PT, Kalter DC, Atherton DJ, Besley GTN, Broadhead DM. Peroxisomal enzyme deficiency in X-linked dominant Conradi-Hunermann syndrome J. Inher. Metab. Dis. 1989; 12 Suppl 2: 358-60 Kalter DC, Atherton DJ, Clayton PT X-linked dominant Conradi-Hunermann syndrome presenting as congenital erythroderma J. Am. Acad. Dermatol. 1989; 21: 248-56 Pike MG, Chang CL, Atherton DJ, Carpenter RG, Preece MA. Growth in atopic eczema: a controlled study by questionnaire. Arch. Dis. Child. 1989; 64: 1566-9 Glover MT, Brett EM, Atherton DJ. Hypomelanosis of Ito: the spectrum of the disease in 19 patients J. Pediatr. 1989; 115: 75-80 Glover MT, Malone M, Atherton DJ. Michelin-tire baby syndrome resulting from diffuse smooth muscle hamartoma. Pediatr. Dermatol. 1989; 6: 329-31 Pike MG, Carter CM, Boulton P, Turner MW, Soothill JF, Atherton DJ. Few-food diets in the treatment of atopic eczema Arch. Dis. Child. 1990; 64: 1691-8 Atherton DJ, Sutton C, Jones BM Mutilating palmoplantar keratoderma with periorificial keratotic plaques - Olmsted's syndrome Brit. J. Dermatol. 1990; 122: 245-52 50 Bunker CB, Atherton D, Gray OP, Tsioupra K, Delhanty JDA, Dowd PM. Familial Raynaud's phenomenon and localised scleroderma associated with essential telangiectasia and cytogenetic abnormalities. J. Roy. Soc. Med. 1990; 83: 531-2 Jardine D, Atherton DJ, Trompeter RS. Sclerema neonatorum and subcutaneous fat necrosis of the newborn in the same infant. Eur. J. Pediatr. 1990; 150: 125-6 Mullett F, Atherton DJ Physiotherapy for epidermolysis bullosa Physiotherapy 1990; 76: 660-2 Salob SP, Atherton DJ, Kiely EM. Thoracic endoscopic sympathectomy for palmar hyperhidrosis in an adolescent female. J. Roy. Soc. Med. 1991; 84: 114-5 8 Glover MT, Lake BD, Harper J, Atherton DJ Infantile systemic hyalinosis: newly recognised disorder of collagen ? Pediatrics 1991; 87: 227-34 Clayton PT, Bridges NA, Atherton DJ, Milla PJ, Malone M, Bender DA. Pellagra with colitis due to a defect in tryptophan metabolism. Eur. J. Pediatr. 1991; 150: 498-502 Sheehan MP, Atherton DJ, Broadbent V, Pritchard J. Topical nitrogen mustard: an effective treatment for cutaneous Langerhans cell histiocytosis. J. Pediatr. 1991; 119: 317-21 Glover MT, Catterall MD, Atherton DJ. Subcutaneous fat necrosis in two infants after hypothermic cardiac surgery. Pediatr. Dermatol. 1991; 8: 210-2 Sheehan M, Atherton DJ. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. Brit. J. Dermatol. 1992; 126: 179-84 Salob SP, Webb DKH, Atherton DJ. A child with xeroderma pigmentosum and bone marrow failure. Brit. J. Dermatol. 1992; 126: 372-4 Glover MT, Atherton DJ A double-blind controlled trial of hyposensitization to Dermatophagoides pteronyssinus in children with atopic eczema. Clin. Exp. Allergy 1992; 22: 440-6 Sheehan MP, Rustin MHA, Atherton DJ, Buckley C, Harris DJ, Brostoff J, Ostlere L, Dawson A. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis: results of a double-blind placebo-controlled study. Lancet 1992; 340: 13-7 Glover MT, Lake BD, Atherton DJ. Clinical, histologic and ultrastructural findings in two cases of infantile systemic hyalinosis. Pediatr. Dermatol. 1992; 9: 255-8 Paige DG, Judge MR, Shaw DG, Atherton DJ, Harper JI. Bone changes and their significance in children with ichthyosis on long-term etretinate therapy. Brit. J. Dermatol. 1992; 127: 387-91 Traupe H, Muller D, Atherton D, Kalter DC, Cremers FPM, van Oost BA, Ropers H-H. Exclusion mapping of the X-linked dominant chondrodysplasia punctata/ ichthyosis/ cataract/ short stature (Happle) syndrome: possible involvement of an unstable premutation. 9 Hum. Genet. 1992; 89: 659-65 Leake J, Sheehan MP, Rampling D, Ramani P, Atherton DJ. Angiosarcoma complicating xeroderma pigmentosum Histopathol. 1992; 21: 179-81 Handfield-Jones S, Atherton DJ, Black MM, Hashimoto K, McKee PH. Juvenile colloid milium: clinical, histological and ultrastructural features. J Cutan Pathol 1992; 19: 434-8 Caffarelli C, Cavagni G, Menzies IS, Bertolini P, Atherton DJ. Elimination diet and intestinal permeability in atopic eczema: a preliminary study. Clin. Exp. Allergy 1993; 23: 28-31 Salob SP, Atherton DJ. The prevalence of respiratory symptoms in children with atopic dermatitis attending pediatric dermatology clinics. Pediatrics 1993; 91: 8-12 Salob SP, Laverty A, Atherton DJ. Bronchial hyperresponsiveness in children with atopic dermatitis. Pediatrics 1993; 91: 13-6 Sheehan MP, Atherton DJ, Norris P, Hawk J Oral psoralen photochemotherapy in severe childhood atopic eczema: an update. Brit. J. Dermatol. 1993; 129: 431-6 Sokel B, Christie D, Kent A, Lansdown R, Atherton D, Glover M, Knibbs J. A comparison of hypnotherapy and biofeedback in the treatment of childhood atopic eczema. Contemporary Hypnosis 1993; 10: 145-54 Coleman R, Malone M, Handfield Jones S, Goodwin P, Rees J, Atherton DJ, Harper JI. Waxy keratoses of childhood. Clin. Exp. Dermatol 1994; 19: 173-6 Sheehan MP, Atherton DJ. One-year follow-up of children treated with traditional Chinese medicinal herbs for atopic eczema. Brit. J. Dermatol. 1994; 130: 488-93 Phillips RJ, Atherton DJ, Gibbs ML, Strobel S, Lake BD. Laryngo-onycho-cutaneous syndrome: an inherited epithelial defect. Arch. Dis. Child. 1994; 70: 319-26 Judge MR, Atherton DJ, Salvayre R, Hilaire N, Levade T, Johnston DI, Winchester B, Lake BD. Neutral lipid storage disease: case report and lipid studies. 10 Brit. J. Dermatol. 1994; 130: 507-10 Ostlere LS, Harris D, Stevens HP, Dillon MJ, Atherton D, van Someren V Rustin MHA. Chronic rash associated with congenital rubella. J. Roy. Soc. Med. 1994; 87: 242-3 Williams HC, Burney PGJ, Hay RJ, Archer CB, Shipley MJ, Hunter JJA, Bingham EA, Finlay AY, Pembroke AC, Graham-Brown RAC, Atherton DJ, Lewis-Jones MS, Holden CA, Harper JI, Champion RH, Poyner TF, Launer J, David TJ. The UK Working Party's diagnostic criteria for atopic dermatitis: I. Derivation of a minimum set of discriminators for atopic dermatitis. Brit. J. Dermatol. 1994; 131: 383-96 Jenkins RE, Kurwa AR, Atherton DJ, Black MM. Neonatal lupus erythematosus Clin. Exp. Dermatol. 1994; 19: 409-11 Dunnill MGS, Richards AJ, Milana G, Mollica F, Atherton D, Winship I, Farrall M, Al-Imara L, Eady RA, Pope FM. Genetic linkage to the type VII collagen gene (COL7A1) in 26 families with generalised recessive dystrophic epidermolysis bullosa and anchoring fibril abnormalities. J Med Genet 1994; 31: 745-8 Latchman Y, Whittle B, Rustin M, Atherton DJ, Brostoff J. The efficacy of traditional Chinese herbal therapy in atopic eczema. Int Arch Allergy Clin Immunol 1994; 104: 222-6 Latchman Y, Bungy GA, Atherton DJ, Rustin M, Brostoff J. Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes. Brit. J. Dermatol. 1995; 132: 592-8 Sheehan MP, Stevens H, Ostlere LS, Atherton DJ, Rustin MHA. Follow-up of adult patients with atopic eczema treated with Chinese herbal therapy for 1 year. Clin. Exp. Dermatol. 1995; 20: 136-40 Dunnill MGS, Rodeck CH, Richards AJ, Atherton D, Lake BD, Petrou M, Eady RA, Pope FM. Use of type VII collagen gene (COL7A1) markers in prenatal diagnosis of recessive dystrophic epidermolysis bullosa. J Med Genet 1995; 32: 749-50 Dawson HA, Atherton DJ. Mayou B. A prospective study of large congenital melanocytic naevi: progress report and evaluation after six years. Brit. J. Dermatol 1996; 134; 617-23 11 Haynes L, Atherton DJ, Ade-Ajayi N, Wheeler R, Kiely EM. Gastrostomy and growth in dystrophic epidermolysis bullosa. Brit J Dermatol 1996; 134: 872-9 Lacour M, Mehta-Nikhar B, Atherton DJ, Harper JI. An appraisal of acitretin therapy in children with inherited disorders of keratinization. Brit. J. Dermatol. 1996; 134: 1023-9 Melville C, Atherton D, Burch M, Cohn A, Sullivan I. Fatal cardiomyopathy in dystrophic epidermolysis bullosa. Brit. J. Dermatol. 1996; 135: 603-6 Vancheeswaran R, Black CM, David J, Hasson N, Harper J, Atherton D, Trevidi P, Woo P. Childhood-onset scleroderma; is is different from adult-onset disease? Arthr Rheum 1996; 39: 1041-9 McGrath JA, Dunnill MGS, Christiano AM, Lake BD, Atherton DJ, Rodeck CH, Pope FM, Eady RAJ, Uitto J. First trimester DNA-based exclusion of recessive dystrophic epidermolysis bullosa from chorionic villus sampling. Brit J Dermatol. 1996; 134: 734-9 Haynes L, Atherton D, Clayden G. Constipation in epidermolysis bullosa: successful treatment with a liquid fiber-containing formula. Pediatr Dermatol 1997; 14: 393-6 Caffarelli C, Cavagni G, Deriu FM, Zanotti P, Atherton DJ Gastro-intestinal symptoms in children with atopic eczema. Arch Dis Child 1998; 78: 230-4 Mellerio JE, Denyer JE, Atherton DJ, Eady RA, McGrath JA. Prognostic implications of determining 180kDa bullous pemphigoid antigen (BPAG2) gene/protein pathology in neonatal junctional epidermolysis bullosa. Brit J Dermatol 1998; 138: 661-6 Mellerio JE, Eady RAJ, Atherton DJ, Lake BD, McGrath JA. E210K mutation in the gene encoding the 3 chain of laminin 5 (LAMB3) is predictive of a phenotype of generalised atrophic benign epidermolysis bullosa. Brit J Dermatol 1998; 139: 325-31 Mellerio JE, Eady RAJ, Atherton DJ, Lake BD, McGrath JA. E210K mutation in the gene encoding the 3 chain of laminin 5 (LAMB3) is predictive of a phenotype of generalised atrophic benign epidermolysis bullosa. Brit J Dermatol 1998; 139: 325-31 Tong L, Hodgkins PR, Denyer J, Brosnahan D, Harper J, Russell-Eggitt I, Taylor DSI, Atherton D. The eye in epidermolysis bullosa. Brit J Ophthalmol 1999; 83: 323-6 12 Slaney SF, Hall CM, Atherton DJ, Winter RM. A new syndrome of spondyloepimetaphyseal dysplasia, and hypogammaglobulinaemia. Clin Dysmorphol 1999; 8: 79-85 Mellerio JE, Ashton GHS, Mohammedi R, Lyon CC, Kirby B, Harman KE, Salas-Alanis JC, Atherton DJ, Harrison PV, Griffiths WAD, Black MM, Eady RAJ, McGrath JA. Epidermolysis bullosa pruriginosa: allelic heterogeneity of type VII collagen gene (COL7A1) mutations. J Invest Dermatol 1999: 112: 984-7 Woolons A, Darley CR, Bhogal BS, Black MM, Atherton DJ Childhood dermatitis herpetiformis Clin Exp Dermatol 1999; 24: 283-5 Mellerio JE, Ashton GH, Mohammedi R, Lyon CC, Kirby B, Harman KE, Salas-Alanis JC, Atherton DJ, Harrison PV, Griffiths WA, Black MM, Eady RA, McGrath JA. Allelic heterogeneity of dominant and recessive COL7A1 mutations underlying epidermolysis bullosa pruriginosa:. J Invest Dermatol 1999; 112: 984-7 Grundy RG, Martinez A, Kempski H, Malone M, Atherton D. Spontaneous remission of congenital leukaemia: a case for conservative treatment. J. Pediatr Hematol Oncol 2000; 22: 252-5 Lees M, Taylor D, Atherton D, Reardon W. Oculo-ectodermal syndrome: report of two further cases. Am J Med Genet 2000; 91: 391-5 Hilhorst-Hofstee Y, Shah N, Atherton D, Harper JI, Milla P, Winter RM. Radial aplasia, poikiloderma and auto-immune enterocolitis - a new syndrome or a severe form of Rothmund-Thomson syndrome? Clin Dysmorphol 2000; 9: 79-85 Martinez AE, Atherton DJ. High-dose systemic corticosteroids can arrest recurrences of severe mucocutaneous erythema multiforme. Pediatr Dermatol 2000; 17: 87-90 Hoeger PH, Nanduri VR, Harper JI, Atherton DJ, Pritchard J. Long-term follow-up of topical nitrogen mustine treatment for cutaneous Langerhans cell histiocytosis Arch Dis Child 2000; 82: 483-7 Sidwell RU, Yates R, Atherton D Dilated cardiomyopathy in dystrophic epidermolysis bullosa. Arch Dis Child 2000; 83: 59-63 Caffarelli C, Deriu FM, Terzi V, Perrone F, De Angelis G, Atherton DJ. Gastro-intestinal symptoms in patients with asthma. Arch Dis Cild 2000; 82: 131-5 13 Shemanko CS, Horn HM, Keohane SG, Hepburn N, Kerr AI, Atherton DJ, Tidman MJ, Lane EB. Laryngeal involvement in the Dowling-Meara variant of epidermolysis bullosa simplex with keratin mutations of severely disruptive potential. Brit J Dermatol 2000; 142: 315-20 Kinsler VA, Aylett SE, Coley SC, Chong WK, Atherton DJ. Central nervous system imaging and congenital melanocytic naevi. Arch Dis Child 2001; 84: 152-5 Bleck O. Ashton GH. Mallipeddi R. South AP. Whittock NV. McLean WH. Atherton DJ. McGrath JA. Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica. Arch Dermatol Res. 2001; 293:392-6 McGrath JA, Duijf PHG, Doetsch V, Irvine AD, de Waal R, Vanmolkot KRJ, Wessagowit V, Kelly A, Atherton DJ, Griffiths WAD, Orlow S, van Haeringen A, Ausems MGEM, Yang A, McKeon F, Bamshad MA, Brunner HG, Hamel BCJ, van Bokhoven H. Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. Hum Mol Genet 2001; 10: 221-9 Latchman YE. Xu XJ. Poulter LW. Rustin MHA. Atherton DJ. Brostoff J Chinese medical herbs in the treatment of atopic dermatitis Allergy & Clin Immunol Int. 2002; 14: 4-9. Murphy L-A, Atherton D A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression Brit J Dermatol 2002; 147: 308-15 Chan MKH, Tucker AT, Madden S, Golding CEM, Atherton DJ, Dillon MJ. Erythromelalgia: an epithelial disorder responsive to nitroprusside. Arch Dis Child 2002; 87: 229-30 Terron-Kwiatkowski A, Paller AS, Compton J, Atherton DJ, McLean WHI, Irvine AD. Two cases of primarily palmoplantar keratoderma associated with novel mutations in keratin 1. J Invest Dermatol 2002; 119: 966-71 Martini G, Murray KJ, Howell KJ, Harper J, Atherton D, Woo P, Zulian F, Black CM. Juvenile onset localized scleroderma activity detection by infrared thermography. Rheumatology 2002; 41: 1178-82 Evans AV, Atherton DJ. Recalcitrant ulcers in necrobiosis lipoidica diabeticorum healed by topical granulocytemacrophage colony-stimulating factor. Brit J Dermatol 2002; 147: 1023-5 Fox AT, Alderdice FA, Atherton D 14 Are Children with Dystrophic Recessive Epidermolysis Bullosa of Low Birthweight? Pediatr Dermatol 2003; 20:303-306. Murphy L-A, Atherton DJ Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency. Pediatr Dermatol 2003; 20: 931-4 Siegel DH. Ashton GH. Penagos HG. Lee JV. Feiler HS. Wilhelmsen KC. South AP. Smith FJ. Prescott AR. Wessagowit V. Oyama N. Akiyama M. Al Aboud D. Al Aboud K. Al Githami A. Al Hawsawi K. Al Ismaily A. Al-Suwaid R. Atherton DJ. Caputo R. Fine JD. Frieden IJ. Fuchs E. Haber RM. Harada T. Kitajima Y. Mallory SB. Ogawa H. Sahin S. Shimizu H. Suga Y. Tadini G. Tsuchiya K. Wiebe CB. Wojnarowska F. Zaghloul AB. Hamada T. Mallipeddi R. Eady RA. McLean WH. McGrath JA. Epstein EH. Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellularmatrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet. 2003; 73:174-87 McLean WHI, Irvine WD, Hamill KJ, Whittock NV, Coleman CM, Mellerio JE, Ashton GS, Dopping-Hepenstal PJH, Eady RAJ, Jamil T, Phillips5, Shabbir SG, Haroon TS, Khurshid K, Moore JE, Page B, Darling J, Atherton DJ, Munro CS, Smith FJD, McGrath JA. An unusual N-terminal deletion of the laminin 3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome. Hum Mol Genet 2003; 12: 2395-409 Hanks S, Adams S, Douglas J, Arbour L, Atherton DJ, Balci S, Bode H, Campbell ME, Feingold M, Keser G, Kleijer W, Mancini G, McGrath JA, Muntoni F, Nanda A, Teare MD, Warman M, Pope FM, Superti-Furga A, Futreal PA, Rahman N. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet 2003; 73: 791-800. Ashton GHS. McLean WHI. South AP. Oyama N. Smith FJD. Al-Suwaid R. Ismaily AA. Atherton DJ. Harwood CA. Leigh IM. Moss C. Didona B. Zambruno G. Patrizi A. Eady RAJ. McGrath JA. Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome. J Invest Dermatol 2004; 122: 78-83 Terron-Kwiatkowski A, Terrinoni A, Didona B, Atherton DJ, Irvine AD, McLean WHI. Atypical epidermolytic palmoplantar keratoderma presentation associated with a mutation in the keratin 1 gene. Brit J Dermatol 2004; 150: 1093-103 Murphy LA, Atherton DJ Porokeratotic eccrine and ostial dermal duct naevus Clin Exp Dermatol 2004; 29: 333-4 15 Juvenile xanthogranuloma with presumed involvement of the optic disc and retina. Hildebrand GD, Timms C, Thompson DA, Atherton DJ, Malone M, Levitt G, Laidlaw DAH, Russell-Eggitt I, Taylor DSI. Arch Opthalmol 2004; 122: 1551-5 Wain EM, Orchard GE, Mayou S, Atherton DJ, Misch KJ, Russell-Jones R. Mycosis fungoides with a CD56+ immunophenotype J Am Acad Dermatol 2005; 53: 158-63 Chew AL, Chan I, McGrath JA, Atherton D Infantile acquired zinc deficiency resembling acrodermatitis enteropathica Clin Exp Dermatol 2005; 30: 594-5 Kinsler VA, Hawk J, Atherton DJ. Diffuse cutaneous mastocytosis treated with psoralen photochemotherapy: case report and review of the literature. Brit J Dermatol 2005; 152: 179-80 Ozanic-Bulic S, Fassihi H, Mellerio JE, McGrath JA, Atherton DJ. Thalidomide in the management of epidermolysis bullosa pruriginosa. Brit J Dermatol 2005; 152: 1332-4 Tejani Z, Batra P, Mason C, Atherton D Focal dermal hypoplasia: oral and dental findings J Clin Pediatr Dent 2005; 30: 67-72 The value of MRI in a patient with occult spinal dysraphism Perera GK, Atherton D Pediatr Dermatol 2006; 23: 24–6. Phillips PS, Amonoo-Kuofi K, Hore ID, Atherton DJ, Albert DM Successful treatment of laryngeal stenosis in laryngo-onycho-cutaneous syndrome with topical mitomycin C. Pediatr Dermatol 2006; 23: 75–7. Complete maternal isodisomy of chromosome 3 in a child with recessive dystrophic epidermolysis bullosa but no other phenotypic abnormalities. Fassihi H, Lu L, Wessagowit V, Ozoemena LC, Jones CA, Dopping-Hepenstal PJ, Foster L, Atherton DJ, Mellerio JE, McGrath JA. J Invest Dermatol 2006; 126: 2039-43 Bone mineralization in children with epidermolysis bullosa. Fewtrell MS, Allgrove J, Gordon I, Brain C, Atherton D, Harper J, Mellerio JE, Martinez AE. Br J Dermatol 2006;154: 959-62 Clinical resolution of a neonatally eroded giant congenital melanocytic naevus. Gass JK, Grant JW, Hall PN, Atherton DJ, Burrows NP. Pediatr Dermatol 2006; 23: 567-70 16 Chan SMH, Dillon MJ, Duffy PG. Atherton D Nephro-urological complications of epidermolysis bullosa in paediatric patients Brit J Dermatol 2007; 156: 143-7 Mazereeuw-Hautier J, Wilson LC, Mohammed S, Smallwood D , Shackleton S, Atherton DJ, Harper JI. Hutchinson-Gilford progeria Syndrome: Clinical findings in three patients carrying the G608G mutation in LMNA and review of the literature. Brit J Dermatol 2007; 156: 1308-14 Ponnampalan J, Nicholson, Atherton D Leptomeningeal melanoma and multiple cutaneous melanocytic naevi. Brit J Dermatol 2007; 157: 397-8 Mazereeuw-Hautier J, Bitoun E, Chevrant-Breton J, Man SY, Bodemer C, Prins C, Saurat JH, Atherton D, Harper JI, Kelsell DP, Hovnanian A Keratitis-ichthyosis-deafness syndrome: disease expression and spectrum of connexion 26 (GJB2) mutations in 14 patients. Brit J Dermatol 2007; 156: 1015-9 Kinsler VA, Chong WK, Aylett SE, Atherton DJ Complications of congenital melanocytic naevi in children: analysis of 16 years’ experience and clinical practice. Brit J Dermatol 2008; 159: 907-14 Zinelli C, Caffarelli C, Strid J, Jaffe A, Atherton DJ Measurement of nitric oxide and 8-isoprostane in exhaled breath of children with atopic eczema. Clin Exp Dermatol 2009; 34: 607-12 Ramesh R, De Silva B, Atherton DJ. Congenital tufted angioma with persistent low-grade coagulopathy. Clin Exp Dermatol 2009; 34: 766-8 Kinsler VA, Birley J, Atherton DJ Great Ormond Street Hospital for Children Registry for Congenital Melanocytic naevi: prospective study 1988. Part 1: Epidemiology, Phenotype and Outcomes. Brit J Dermatol 2009; 160: 143-50 Kinsler VA, Birley J, Atherton DJ Great Ormond Street Hospital for Children Registry for Congenital Melanocytic naevi: prospective study 1988. Part 2: Evaluation of treatments. Brit J Dermatol 2009; 160: 387-92 Natkunarajah J, Atherton D, Emslie F, Mansour S, Mortimer P. Treatment with carbamazepine and gabapentin of a patient with primary erythermalgia (erythromelalgia) identified to have a mutation in the SC9A gene, encoding voltage-gated sodium channel. Clin Exp Dermatol 2009; 34: 640-2 17 Paul SP, Vamvakiti E, Atherton DJ, Candy DC. Acrodermatitis enteropathica variant with borderline plasma zinc concentrations. J Pediatr Gastroenterol Nutr 2011; 52: 630 Weibel L, Laguda B, Atherton D, Harper JI. Misdiagnosis and delay in referral of children with localized scleroderma. Brit J Dermatol. 2011; 165: 1308-13 - Kinsler V, Abu-Amero S, Budd P, Jackson I, Ring S, Northstone K, Atherton D, Bulstrode N, Stanier P, Hennekam R, Sebire N, Moore G, Healy E. Study of congenital melanocytic naevi reveals a role for melanocortin-1-receptor genotype in human fetal growth. J. Invest. Dermatol. 2012; 132: 2026-32 Waelchli R, Aylett SE, Atherton D, Thompson D, Chong WK, Kinsler VA. Classification of neurological abnormalities in children with congenital melanocytic naevi identifies MRI as the best predictor of clinical outcome. Br J Dermatol 2015; 1173: 739-50 150 In Press Thomas AC, Zeng Z, Rivière J-B, O’Shaughnessy R, Al-Olabi L, St-Onge J, Atherton DJ, Aubert H, Barbarot S, Bourrat E, Chiaverini C, Chong WK, Duffourd Y, Glover M, Groesser L, Hadj-Rabia S, Hamm H, Happle R, Khan I, Lacour J-P, Waelchli R5, Wobser M, Vabres P, Patton EE and Kinsler VA Mosaic activating mutations in GNA11 and GNAQ are associated with phakomatosis pigmentovascularis and extensive dermal melanocytosis J. Invest. Dermatol. 2015 18 Reviews and editorials: Atherton DJ. Joseph Towne: wax modeller extraordinary. J. Am. Acad. Dermatol. 1980; 55: 547-50 Atherton DJ. Dietary antigen avoidance in the treatment of atopic eczema. Acta Dermatovener. (Stockh) 1980; suppl 92: 99-102 Atherton DJ. Allergy and atopic eczema I. Clin. Exp. Dermatol. 1981; 6: 191-203 Atherton DJ. Allergy and atopic eczema II. Clin. Exp. Dermatol. 1981; 6: 317-25 Atherton DJ, Marshall WC Eczema herpeticum. Practitioner 1982; 226: 970-3 Barnetson RStC, Atherton DJ. Clinical aspects of the endogenous eczemas. Medicine 1983; 23: 1255-66 Atherton DJ. The role of foods in atopic eczema. Clin. Exp. Dermatol. 1983; 8: 227-32 Atherton DJ. Breast feeding and atopic eczema: Editorial Brit. Med. J. 1983; 287: 775-6 Atherton DJ Skin disorders and food allergy. J. Roy. Soc. Med. 1985; 77 Suppl 5: 7-10 Atherton DJ. Diagnosis and management of skin disorders caused by food allergy. Annls. Allergy 1984; 53: 623-6 Atherton DJ. Significance of food hypersensitivity in children with atopic eczema. Pediatr. Dermatol. 1986; 3: 161-3 Novelli VM, Atherton DJ, Marshall WC. Eczema herpeticum Clin. Pediatr. 1988; 27: 231-3 19 Atherton DJ Diet and atopic eczema Clin. Allergy 1988; 18: 215-28 Atherton DJ Role of diet in treating atopic eczema: elimination diets can be helpful. Brit. Med. J. 1988; 297: 1458-60 Atherton DJ. Corticosteroids for erythema multiforme ? Pediatr. Dermatol. 1989; 6: 246-9 Temple IK, Macdowall P, Baraitser M, Atherton DJ Focal dermal hypoplasia J. Med. Genet. 1990; 27: 180-7 Atherton DJ. The role of house dust mites in the etiology of atopic dermatitis. Eur. J. Pediatr. Dermatol. 1991; 1: 41-4 Atherton DJ Atopic disease and food allergy. Clin. Exp. Allergy 1991; 21: 649-50 Aylett SE, Atherton DJ, Preece MA. The treatment of difficult atopic dermatitis in childhood with beclomethasone dipropionate. Acta Dermatol. Venereol. (Stockh). 1992; suppl. 176: 123-5 Allman S, Haynes L, Mackinnon P, Atherton DJ. Nutrition in dystrophic epidermolysis bullosa. Pediatr. Dermatol. 1992; 9: 231-8 Atherton DJ, Sheehan MP, Rustin MHA, Whittle B, Guy G. Treatment of atopic eczema with traditional Chinese medicinal plants. Pediatr. Dermatol. 1992; 9: 373-5 Atherton DJ Towards the safer use of traditional remedies (Editorial) Brit. Med. J. 1994; 308: 673-4 Atherton DJ Phototherapy for children Pediatr Dermatol 1996; 13: 415-26 Atherton DJ Management of infantile haemangiomas Hong Kong Journal of Paediatrics 1998; 3: 89-102 20 Atherton DJ, Cox I, Hann I. Intravenous iron (III) hydroxide-sucrose complex for anaemia in epidermolysis bullosa. Brit J Dermatol 1999; 140: 773 Atherton DJ The aetiology and management of irritant diaper dermatitis J Europ Acad Dermatol Venereol 2001; 15 Suppl 1: 1-4 Atherton David J Topical corticosteroids in atopic dermatitis (Editorial) Brit Med J 2003; 327: 942-3 Atherton DJ, Mills K. What can be done to keep babies’ skin healthy? Midwives 2004; 7: 288-90 Atherton DJ. A review of the pathophysiology, prevention and treatment of irritant diaper dermatitis. Curr Med Res Opin 2004; 20: 645-9 Atherton D. Maintaining healthy skin in infancy using prevention of irritant napkin dermatitis as a model. Community Practitioner 2005; 78: 255-7 Atherton DJ Infantile haemangiomas Early Human Development 2006; 82: 789-95 Atherton DJ A review of the pathophysiology, prevention and treatment of irritant diaper dermatitis. Curr Med Res Opin 2004; 20: 645-9 150 peer-reviewed papers 32 editorials and reviews 32 chapters 2 books 21 22