WATER
RTECS NUMBER : ZC0110000
CHEMICAL NAME : Water
CAS REGISTRY NUMBER : 7732-18-5
LAST UPDATED : 199710
DATA ITEMS CITED : 20
MOLECULAR FORMULA : H2-O
MOLECULAR WEIGHT : 18.02
WISWESSER LINE NOTATION : QH
COMPOUND DESCRIPTOR : Mutagen
Human
SYNONYMS/TRADE NAMES :
* Dihydrogen oxide
* Distilled water
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - infant
DOSE/DURATION : 333 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB
560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year:
54,551,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 42.86 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle contraction or spasticity
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 29,135,1926
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Rectal
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 180 gm/kg/28H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - nausea or vomiting
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
104,1569,1935

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >90 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 190 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD628-313
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MIVRA6 Microvascular Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1968- Volume(issue)/page/year: 8,320,1974
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 629 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 29,135,1926
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 320 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 29,135,1926
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 368 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 29,135,1926
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 13 gm/kg
TOXIC EFFECTS :
Blood - other hemolysis with or without anemia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 29,135,1926
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Rectal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 450 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - muscle contraction or spasticity
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
104,1569,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 429 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 29,135,1926
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3502 gm/kg/2W-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 29,135,1926
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1000
No. of Facilities: 436805 (estimated)
No. of Industries: 561
No. of Occupations: 294
No. of Employees: 7313166 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1000
No. of Facilities: 313467 (estimated)
No. of Industries: 500
No. of Occupations: 324
No. of Employees: 8785413 (estimated)
No. of Female Employees: 3032116 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8787;8EHQ-0892-8800
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999