Miriam L Wahl, PhD
5 Briarfield Court ~ Durham NC 27713
Cell: 443-676-7498 Home: 919-294-9243
Miriam.Wahl@gmail.com
RESEARCHER/EDUCATOR
Teaching ~ Scientific Research ~ Medical Writing/Editing ~ Experimental Design
Teacher and researcher with extensive experience in teaching of high school students, undergraduates,
graduate students, and medical students. Strengths include cell and molecular biology, biochemistry,
physics, chemistry, and pathology, fluorescence microscopy. Twenty seven years of research
experience, author of 45 peer-reviewed manuscripts.
TEACHING EXPERIENCE
THE CALVERTON SCHOOL-Huntingtown, MD 2011-2012
Full Time Faculty
 Teaching 3 sections of 10th grade Chemistry and one section of AP Biology
UNIVERSITY OF BALTIMORE, Division of Liberal Studies - Baltimore, MD 2010-11
Adjunct Faculty, Chemistry
 Teaching two sections/classes of a chemistry course that includes environmental issues,
biochemistry of the human body, drugs, and nutrition
 Development of powerpoint presentations, take home and in class exams, writing assignments
ITT TECHNICAL INSTITUTE, Division of General Studies - Owings Mills, MD 2010-11
Adjunct Professor
 Teaching 3 classes per week-problem solving; a combination of mathematics and physics
ADVANCED LEANER’S INC and UNIVERSITY INSTRUCTORS – Durham, NC and Baltimore, MD 2009-2010
Tutor
 High school biology, chemistry, and physics
 Elementary school math and reading
JOHNS HOPKINS UNIVERSITY, Baltimore, MD 2010
Microscopy Specialist
 Teaching, training, and assisting graduate students and post-doctoral fellows with
microscopy needs
 Troubleshooting in the principles of confocal and light microscopy, tissue culture,
research development
DUKE UNIVERSITY, Durham, NC 2002 – 2007
Assistant Professor – PATHOLOGY & RADIATION ONCOLOGY,
Hired as an Assistant Professor on the tenure track.
 Developed and presented lectures to classes of 12-30 MD/PhD students and postdoctoral fellows.
 Led seminar and workshops
 Led students in researching, presenting, and reviewing papers; including coaching with
respect to learning skills to evaluate the literature.
 Presented annually at Grand Rounds.
 Developed and delivered presentations at NIH study sections, NIH site visits and
reverse site visits, both live and via video teleconference.
Miriam L Wahl, PhD
5 Briarfield Court ~ Durham NC 27713
Cell: 443-676-7498 Home: 919-294-9243
Miriam.Wahl@gmail.com
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Lecture on pH regulation in tumor microenvironment and fluorescence techniques in
molecular aspects of disease for graduate students and MD/PhD students.
Served as Course Coordinator for one year, running the course on molecular aspects of
disease for graduate students; lectured on pH regulation in the tumor
microenvironment, cystic fibrosis, and fluorescence techniques.
THOMAS JEFFERSON UNIVERSITY, Philadelphia, PA , 1998 – 2002
Research Assistant Professor – BIOCHEMISTRY & MOLECULAR PHARMACOLOGY
Lectured graduate students on fluorescence techniques in “Protein structure and function” run
by Dr. Allen Zeiger.
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Lectured graduate students on role of extracellular matrix proteins in tumor biology in
“Extracellular matrix proteins” course run by Dr. Barbara Schick.
Conducted seminars/group discussions with medical students in first year biochemistry
course.
Developed and presented lectures to diverse students including residents and fellows
of Departments of Radiation Biology and Radiation Physics in “Apoptosis-mediated
mechanisms and their role in Radiation Response”.
EDUCATION
Bachelor of Science (BS) Biochemistry 1976 –1980
UNIVERSITY OF TORONTO, Toronto, Ontario, Canada.
Master of Science (MS) Pathology 1982 – 1984
UNIVERSITY OF TORONTO, Toronto, Ontario, Canada.
THESIS: GLUTATHIONE METABOLISM IN HEPATOCYTE NODULES DURING HEPATOCARCINOGENESIS
Advisor: Emmanuel Farber, MD, PhD, and Chair of the Department of Pathology.
Doctor of Philosophy (PhD) Molecular Genetics, Biochemistry, and Microbiology 1985 – 1990
UNIVERSITY OF CINCINNATI, Cincinnati, OH.
DISSERTATION: INTRACELLULAR FREE CALCIUM SIGNALING IN THE CELL CYCLE
Published seven manuscripts
Advisor: Eric I Gruenstein, PhD, Professor
Selected Professional Honors
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Travel Award, Annual Radiation Research Society Meeting, Chicago, IL, 1996
Invited Speaker, The Tumor Microenvironment, Stanford University International Workshop: An
important paradigm in cancer etiology and treatment, Martha’s Vineyard, MA, 1997
Fundraising Committee, Planning Committee, & Guest Speaker, Annual Meeting, American Society
for Photobiology, Snowbird, UT, 1998
Invited Speaker, The Tumor Microenvironment Stanford University International Workshop: An
Miriam L Wahl, PhD
5 Briarfield Court ~ Durham NC 27713
Cell: 443-676-7498 Home: 919-294-9243
Miriam.Wahl@gmail.com
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important paradigm in cancer etiology and treatment; Atlanta, GA, April 19-21, 2001
Invited Speaker, Radiation Research Society 48th Annual Meeting, San Juan, PR, 2001
Invited Speaker, International Meeting, Angiogenesis, Basic Science and Clinical Relevance, Crete,
Greece, June 26-July 2, 2001
Guest Speaker, The Tumor Microenvironment M.D. Anderson Cancer Center / U of Texas 10th
Annual Radiation Workshop. Biology and Clinical Implications, Round Top, TX, April 25-28, 2002.
Invitee, Gordon Conference in Radiation Oncology, Ventura, CA, January 26-31, 2003.
Member, Duke University Pathology Graduate Faculty, October 2003-Present.
Member, Duke Comprehensive Cancer Center, November 2003-Present .
Founding Member, Society for Melanoma Research, 2003.
Invited Speaker, FASEB Transport ATPase Conference, Ectopic localization of mitochondrial ATP
synthase, a target for anti-angiogenesis intervention? Saxtons River, VT, July 16-21, 2005.
Invited Speaker, The Tumor Microenvironment 10th International Workshop, Three new therapeutic
targets revealed by experimentation at low tumor-like extracellular pH, Boston, MA, Sept 2006.
Invited, Medical Scientist Training Program Research Symposium Durham, NC, March 2007.
FDA Invited Speaker, White Oak Seminar Series, Silver Spring, MD, April 11, 2007; was awarded a
commemorative plaque at lecture.
Congressional Liaison, American Society of Cell Biology, 1997-Present.
Reviewer of manuscripts for Cancer Research, Molecular Cancer Therapeutics, and the International
Journal of Hyperthermia.
Member, American Medical Writers Association, 2008.
Invited Speaker, Office of the Medical Examiner, December 8, 2008; New York, New York.
Invited Speaker, at the first (unofficial) meeting of The International Society for Proton Dynamics in
Cancer, Madrid, Spain, April 27-28, 2009.
Invited Speaker, at the first official annual meeting of the International Society for Proton Dynamics in
Cancer, Rome, Italy, Sept 27-8, 2010.
RESEARCH EXPERIENCE
THOMAS JEFFERSON UNIVERSITY, Philadelphia, PA 1993 – 1997
Post-Doctoral Fellow –BIOCHEMISTRY
Conducted research on measurement of intracellular pH in tumor cells, brought techniques
from the spectrophotometer to the microscope stage to perform experiments on cells attached
to physiological tumor matrix proteins.
THE WISTAR INSTITUTE, Philadelphia, PA 1997 – 1998
Post-Doctoral Fellow – STRUCTURAL BIOLOGY
Conducted research in cellular and structural biology as part of a melanoma program project headed
by Dr. Meenhard Herlyn, president of the Society for Melanoma Research.
THOMAS JEFFERSON UNIVERSITY, Philadelphia, PA 1998 – 2002
Research Assistant Professor – BIOCHEMISTRY & MOLECULAR PHARMACOLOGY
Miriam L Wahl, PhD
5 Briarfield Court ~ Durham NC 27713
Cell: 443-676-7498 Home: 919-294-9243
Miriam.Wahl@gmail.com
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Worked under the direction of Charles S. Owen, PhD, and independently, and as part of a program
project team headed by Dennis B. Leeper on enhancement of radiation and hyperthermia therapy
with acidification.
Played active role in early research and development to take intracellular pH measurement from
suspended cells to attached cells, under physiological conditions of temperature and substrate
proteins, and performed calculation of intracellular pH from whole spectrum fluorescence
measurements with original computer software.
Supervised post-doctoral students, graduate students, undergraduates and technicians.
SELECTED ACCOMPLISHMENTS:
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Developed an original and exceptionally accurate technique for measurement of intracellular ion
concentrations using dual wavelength fluorescent indicator dyes.
Identified the first 2 of 5 transporters that affect intracellular pH in tumor tissue.
Using this approach and testing inhibitors of intracellular pH regulation, discovered how cells in
tumor microenvironment maintain their intracellular pH in the viable range.
DUKE UNIVERSITY, Durham, NC 2002 – 2007
Assistant Professor – PATHOLOGY & RADIATION / ONCOLOGY
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Collaborated with Drs. Mark W. Dewhirst, Salvatore V. Pizzo, David J. Adams, O. Michael Colvin,
Susan Ludeman, Susan Kreissman, and Maureanne Hoffman, from an independent laboratory at
Duke University as part of program project team in a neuroblastoma project.
Continued research that began in Philadelphia with the program project team headed by Dennis B.
Leeper as a sub-contract.
Managed all aspects of laboratory operations while leading research projects in original and assisted
numerous students and technicians with cell biology and tissue culture problems.
Conceptualized, designed, and developed novel experimental assays.
Trained and supervised post-doctoral fellows, graduate students, and laboratory technicians in
measurement of intracellular ion concentrations using my own (self-designed) original equipment
and computer software, traditional techniques, and teaching of sterile technique.
Lead project meetings and staff discussions, brainstorming innovative methods to achieve results.
Obtain fluorescent signals from inside cells, using original software to calculate intracellular pH and
free calcium concentrations, and subsequently evaluate and analyze data.
Authored grants and manuscripts; reported research results in peer-reviewed and non-peer
reviewed forums.
Leveraged original data in grant applications for NIH and other funding.
Reviewed and presented progress reports and performance reviews on students and staff.
EDUCATION & TRAINING SYSTEMS INTERNATIONAL, Chapel Hill, NC 2008
Medical Writer/Editor
Wrote and edited materials to train pharmaceutical representatives who need to understand medical
diseases and the available means to treat them.
Miriam L Wahl, PhD
5 Briarfield Court ~ Durham NC 27713
Cell: 443-676-7498 Home: 919-294-9243
Miriam.Wahl@gmail.com
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Clients included all of the major US pharmaceutical companies and writing was about a diverse set
of diseases.
Extensive interaction with layout, quality control, project leaders, project managers, and clients.
OFFICE OF THE CHIEF MEDICAL EXAMINER FOR NORTH CAROLINA, Chapel Hill, NC 2008
Toxicology trainee – using specimens delivered from autopsy 
Accession of post-mortem specimens
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Chain of custody procedures, standard operating procedures, protocol refinement
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Analyses of blood, urine, serum, vitreous, plasma, and tissue homogenates for the following:
1) Ethanol, methanol, acetone, and propanol. These volatiles are analyzed using headspace gas
chromatography (GC) with flame ionization detection.
2) Carbon monoxide levels (% COHb) using a CO-Oximeter and using palladium.
3) Organic base drug screen (includes numerous legal and illegal drugs using GS/MS.
4) Acidic and Neutral Drug detection by gas chromatography.
5) Enzyme Immuno Assay using a Microgenics MGC0240 Chemical Analyzer and software.
PUBLICATIONS & PRESENTATIONS
PEER REVIEWED PUBLICATIONS [NOTE: Early articles published under former name of Ahluwalia]:
1. Eriksson L, Ahluwalia M, Spiewak J, Lee G, Sarma DSR, Roomed MW, Farber E (1982)
Hepatocyte Nodules in Liver Carcinogenesis. Environmental Health Perspectives 49:171-174.
2. Roberts E, Ahluwalia MB, Lee G, Chan C, Sarma DSR, Farber E (1983) Resistance to
Hepatotoxins Acquired by Hepatocytes During Liver Regeneration. Cancer Res 43:28-34.
3. Ahluwalia MB, Rotstein J, Tatematsu M, Roomi MW, Farber E (1983) Failure of Glutathione
to Prevent Liver Cancer Development in Rats Initiated with Diethylnitrosamine in the
Resistant Hepatocyte Model. Carcinogenesis 4:119-121.
4. Ghoshal AK, Ahluwalia M, Farber E (1985) The Rapid Induction of Liver Cell Death in Rats
Fed a Choline-deficient Methionine-low Diet. Am J of Pathology 113:309-314.
5. Moslen MT, Ahluwalia MB, Farber E (1985) 1,-2-Dibromoethane Initiation of Hepatic
Nodules in Sprague-Dawley Rats Selected with Solt-Farber System. Archives of Toxicology
58:118-119.
6. Ghoshal A, Roomi MW, Ahluwalia M, Simmonds W, Rushmore TH, Farber E, and Ghoshal AK
(1988) Glutathione and Enzymes Related to Free Radical Metabolism in Liver of Rats Fed A
Choline-devoid Low-Methionine Diet. Cancer Letters 41:53-62.
7. Lin P, Ahluwalia M, and Gruenstein E (1988) Regulation of Conductive Cl- Transport in
Human Fibroblasts. American J of Physiology 255:C552-C558.
8. Johnson, CL, Johnson, CG, Bazan, E, Garver, D, Gruenstein, E, and Ahluwalia, M (1990)
Histamine H1 Receptors in Human Fibroblasts: Stimulation of Intracellular Calcium.
American Journal of Physiology 258:C533-C543.
9. Lin P, Ahluwalia M, and Gruenstein E (1990) Regulation of Cl-/Anion exchange pathway by
intracellular pH in human fibroblasts. American J of Physiology 258:C132-C139.
10. Wahl M, Lucherini M, and Gruenstein E (1990) Intracellular Ca2+i measurement using Indo-1
in substrate-attached cells: advantages and special considerations. Cell Calcium 11:487-500.
11. Wahl M, Sleight R, and Gruenstein E (1992) Association of cytoplasmic free Ca2+i gradients
with subcellular organelles. J of Cellular Physiology 150: 593-602.
12. Wahl M, and Gruenstein E (1993) Intracellular free Ca2+ in the cell cycle in human
fibroblasts: transitions between G1 and G0 and progression into S Phase. Molecular Biology
Miriam L Wahl, PhD
5 Briarfield Court ~ Durham NC 27713
Cell: 443-676-7498 Home: 919-294-9243
Miriam.Wahl@gmail.com
of the Cell 4:293-302.
13. Owen CS, Wahl ML, Leeper DB, Perry HD, Bobyock SB, Russell M, Woodward, W (1995)
Accurate Whole Spectrum Measurements of Intracellular pH and [Na+]. J of Fluorescence
5:329-335.
14. Coss RA, Messinger JA, Wahl ML, Wachsberger, PR, Leeper, DB, and Owen, CS (1997)
Bicarbonate-dependent proton extrusion in CHO cells adapted to growth at pH 6.7.
International J of Hyperthermia 13:325-326.
15. Wahl ML, Leeper DB, and Owen CS (1997) Effects of 42C hyperthermia on intracellular pH
in ovarian carcinoma cells during acute acidification or chronic exposure to low
extracellular pH. International J of Radiation Oncology, Biology, and Physics 39:205-212.
16. Owen CS, Pooler PM, Wahl ML, Bobyock SB, Coss RA, and Leeper DB (1998) Altered
proton extrusion in cells adapted to growth at low extracellular pH. J of Cellular Physiology
173:397-405.
17. Pooler PM, Wahl ML, Rabinowitz AB, Owen CS (1998) pH Measurement: A comparison of
results using glass electrodes vs. solid-state electrodes as a function solution composition.
Analytical Biochemistry 256:238-240.
18. Wahl ML, Pooler PM, Leeper DB, Briand PB, Owen CS (2000) Intracellular pH regulation in a
non-malignant and a derived malignant breast cell line. J of Cell. Physiology 183:373-380.
19. Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, and Leeper DB (2001) Met-iodobenzylguanidine plus glucose inhibits respiration and induces acidification in human melanoma
cells adapted to growth at low pH. Cancer Res 61:5630-5635.
20. Wachsberger PR, Burd R, Wahl ML, and Leeper DB (2001) Betulinic Acid sensitization of low
pH adapted melanoma cells to hyperthermia. International J of Hyperthermia 18: 153-164.
21. Wahl ML and Grant DS (2002) Effects of microenvironmental extracellular pH and
extracellular matrix proteins on angiostatin’s activity and on intracellular pH. General
Pharmacology (Vascular Research) 35:277-285.
22. Moser TL, Stack MS, Wahl ML, and Pizzo SV (2002) The mechanism of action of Angiostatin:
Can you teach an old dog new tricks? Thrombosis and Haemostasis 87:394-401.
23. Han J-S, Storck CW, Wachsberger PW, Wahl ML, Leeper DB, Berd D and Coss RA (2002)
Acute acidification increases nuclear associated protein levels in human melanoma cells
during 42C hyperthermia and enhances cell killing. Int J of Hyperthermia 18:404-415.
24. Halaban R, Patton R, Cheng E, Svedine S, Trobetta ES, Wahl ML, and Hebert DN (2002)
Tumor induced acidification suppresses catalytic activity and ER to Golgi transport of
tyrosinase. J of Biological Chemistry 277:14821-14828.
25. Wahl ML, Owen CS, and Grant DS (2002) Angiostatin induces intracellular acidosis and
anoikis in endothelial cells at a tumor-like low pH. Endothelium 9:205-216.
26. Wahl ML, Owen JA, Burd R, Rodeck U, Herlands R, Nogami S, Berd R, Leeper DB and Owen
CS (2002) Regulation of intracellular pH in human melanoma cell lines: potential
therapeutic implications. Molecular Cancer Therapeutics 1:617-628.
27. Rouan F, Lo CW, Fertala A, Wahl M, Jost M, Rodeck U, Uitto J, and Richard G (2003)
Divergent effects of two sequence variants of GJB3 (G12D and R32W) on the function of
connexin 31 in vitro. Experimental Dermatology 12:191-197.
28. Burd R, Lavorgna SN, Daskalakis C, Wachsberger PR, Wahl ML, Biaglow JE, Stevens, C, and
Leeper DB (2003) Tumor oxygenation and acidification are increased in melanoma after
exposure to meta-iodo-benzylguanidine and hyperglycemia. Radiation Res 59:328-335.
29. Wachsberger PR, Burd R, Bhala A, Bobyock SB, Wahl ML, Owen CS, Rifat SB and Leeper
Miriam L Wahl, PhD
5 Briarfield Court ~ Durham NC 27713
Cell: 443-676-7498 Home: 919-294-9243
Miriam.Wahl@gmail.com
DB (2003) Quercetin sensitizes cells in a tumor-like low pH environment to hyperthermia.
International J of Hyperthermia, 19:507-519.
30. Coss RA, Storck CW, Daskalakis C, Berd D, and Wahl ML (2003) Intracellular Acidification Abrogates the Heat Shock Response and Compromises Survival of Human
Melanoma Cells. Molecular Cancer Therapeutics 2: 383-388.
31. Wahl ML, Moser TL and Pizzo SV (2004) Angiostatin and Anti-Angiogenic Therapy in Human
Disease. Recent Progress in Hormone Research Chapter 5, pg. 73-104.
32. Coss RA, Storck CS, Wachsberger PR, Reilly J, Leeper DB, Berd D, and Wahl ML (2004) Acute
extracellular acidification reduces intracellular pH; 42C induction of heat shock proteins
and clonal survival of human melanoma cells at pH 6.7. International J of Hyperthermia
20:93-106.
33. Burwick N and Wahl ML, Capaldi RA, Kenan DJ, and Pizzo SV (2005) An inhibitor of the F1
sub-unit of ATP Synthase (IF1) modulates the activity of angiostatin on the endothelial cell
surface. J of Biological Chemistry 280:1740-1745.
34. Adams DJ, Wahl ML, Flowers JL, Sen B, Colvin M, Dewhirst MW, Manikumar G, Wani MC
(2005) Camptothecin analogs with enhanced activity against human breast cancer cells:
impact of the tumor pH gradient Cancer Chemotherapy and Pharmacology July 5, 1-10.
35. Wahl ML, Kenan DJ, Gonzalez-Gronow M, and Pizzo SV (2005) Angiostatin’s molecular
mechanism: aspects of specificity and regulation elucidated. J of Cellular Biochemistry
96:242-261 (invited review).
36. Kenan DJ and Wahl ML (2005) Ectopic localization of ATP Synthase: A target for antiangiogenesis intervention? J of Bioenergetics and Biomembranes 37:461-465.
37. Fang J, Quinones QJ, Holman TL, Morowitz M, Wang Q, Zhao H, Sivo F, Maris JM, and Wahl
ML (2006) The H+-linked Monocarboxylate Transporter (MCT1/SLC16A1): A potential
therapeutic target for high-risk neuroblastoma. Molecular Pharmacology 70:1-8.
38. Chi SL, Wahl ML, Mowery YM, Shan S, Mukhopadhyay S, Hildebrand S, Kenan DJ, Lipes,
BD, Johnson CE, Marusich MF, Capaldi RA, Dewhirst MW, and Pizzo SV (2007)
Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1Fo ATP
synthase. Cancer Research 67:1-9
39. Sonveaux P, Vegran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ,
Kennedy KM, Diepart C, Jordan BF, Kelley MJ, Gallez B, Wahl ML, Feron O, Dewhirst
MW (2008) Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in
mice. J of Clinical Investigation 118:3835-7.
40. Harguindey S, Arranz JL, Wahl ML, Orive G, and Reshkin SJ (2009) Proton transport
Inhibitors as Potentially Selective Anticancer Drugs. Anticancer Research 29: 3-12.
41. Rauch C, Blanchard A, Wood E, Dillon E, Wahl ML, Harguindey S (2009) Cell Membranes,
Cytosolic pH, and Drug Transport in Cancer and MDR: Physics, Biochemistry, and
Molecular Biology. In: Multiple Drug Resistance (Chapter 3). Agoston Meszaros
and Gusztav Balogh (eds). Nova Science Publishers, Inc.
42. Huber V, De Milito A, Harguindey S, Reshkin SJ, Wahl ML, Rauch C, Chiesi A,
Pouyssegur J, Gatenby RA, Rivoltini L, and Fais S. (2010) Proton Dynamics in Cancer,
J of Translational Medicine 8:57-60.
43. Huber, V, De Milito, A, Harguindey, S, Reshkin, SJ, Wahl, ML, Rauch, C, Chiesi, A,
Pouyssegur, J, Gatenby, RA, Pérez-Sayáns M, Cacabelos, R, Arranz JL, Rivoltini L,
Fais S (2010) Manifesto cientifico de la Soceidad Internacional para el Estudio de la
Dinámica de Protones en al Cáncer (ISPDC). Gen-T June 2010 pg. 75-80.
44. Milosavljevic, N, Blanchard, A, Wahl, ML, Harguindey, S, Poet, M, Counillon, L, Rauch, C
(2011) Teaching Old Dogs New Tricks: Membrane Biophysical Properties in Drug
Delivery and Resistance. Recent Patents on Cancer Drug Discovery 334-346.
Miriam L Wahl, PhD
5 Briarfield Court ~ Durham NC 27713
Cell: 443-676-7498 Home: 919-294-9243
Miriam.Wahl@gmail.com
NON PEER-REVIEWED PUBLICATIONS:
1. Wahl ML, Book Review: “Protein Kinase C”, The Physiologist, 38: 43, 1995.
2. Wahl ML, Glutathione and Related Enzymes in Early Putative Preneoplastic Hepatocyte Nodules, in
The Molecular Pathology of Disease. 1997; eds. Robert Kisilevsky, Russell M. Lebovitz, Robert E. Lee,
and Michael W. Lieberman.
http://www.bcm.tmc.edu/pathology/Dept/researchs/lieberman/festschrift/fest.html .
3. Leeper DB, Bobyock SB, Bhala A, Wahl ML and Owen CS (1996). The Effect of the Stilbene, DIDS, on
the Thermal Response of Cell Adapted to Growth at Low pHe. Proceedings 7th International Congress
of Hyperthermic Oncology, Tor Vergata, Rome, Italy. Franconi, C, Arcangeli, G, and Cavaliere, R (Eds),
Vol. II, p. 704-6.
4. Owen CS, Wahl, ML, Bobyock SB, and Leeper DB (1996) Intracellular pH during 42C hyperthermia
and/or exposure to DIDS in cells acutely or chronically exposed to low medium pH. Proceedings of
the 7th International Congress of Hyperthermic Oncology, Tor Vergata, Rome, Italy, Franconi, C,
Arcangeli, G, and Cavaliere, R (Eds) Vol. II, p 709-10.
5. Wahl ML, Pooler PM, Owen CS, Coss RA, Iliakis G, Glickson J, and Leeper DB (1998) Reversal of
hyperthermia resistance by inhibitors of pH regulation in human melanoma cells. Photochemistry
and Photobiology, 67: 44S-45S.
ORAL PRESENTATIONS:
1. Inhibition of intracellular pH regulation in human melanoma cells as a function of
microenvironmental pH. ML Wahl. Second Annual Tumor Microenvironment Workshop, Martha’s
Vineyard. Sponsored by Stanford University, April 1998.
2. Reversal of hyperthermia resistance by inhibitors of pH regulation in human melanoma cells. ML
Wahl, PM Pooler, CS Owen, RA Coss, G Iliakis, J Glickson, and DB Leeper. Annual Meeting, American
Society for Photobiology, Snowbird, Utah, July 11-15, 1998. Invited guest speaker and fund raising
and planning committee member.
3. The study of low pH adaptation of tumor cells and its ramifications for therapy. ML Wahl, RA Coss,
DB Leeper, and CS Owen. 4th Annual Meeting of the Cell Proliferation Society. Baltimore, MD March
1999.
4. The study of low pH adaptation of tumor cells and its ramifications for therapy. ML Wahl, CS Owen.
North American Hyperthermia Society. Philadelphia, PA 1999. Invited speaker and Co-Chair of
symposium.
5. Effects of adaptation to growth at low pH on intracellular pH in human melanoma cells acutely
acidified and/or heated to 42C. ML Wahl, CS Owen, RA Coss, and DB Leeper. North America
Hyperthermia Society, Philadelphia, PA 1999. Invited guest speaker and Co-Chair of a symposium.
6. Acute acidification enhances the effect of angiostatin on intracellular pH and lethality in aortic ring
sprouts. ML Wahl, CS Owen, AR Page, ML Zahachewsky, AP Dicker, DB Leeper, DS Grant. Radiation
Research Society/North American Hyperthermia Society meeting, San Juan, Puerto Rico, 2001
Invited Speaker and Symposium Chair.
7. Melanoma cells exhibit an unusual proton transport phenotype particularly at low extracellular pH.
ML Wahl, JA Owen, AR Page, CM Fleming, R Herlands, SS Nogami, K Fulcher, DB Leeper, CS Owen.
7th International Tumor Microenvironment Workshop Atlanta, GA, April 19-21, 2001.
8. Intracellular pH regulation in tumor cells and endothelial cells during angiogenesis: implications for
therapy. ML Wahl. The 10th Annual Radiation Workshop, Round Top, TX, April 25-28, 2002.
9. Regulation of intracellular pH by the monocarboxylic acid transporters in human melanoma cells:
therapeutic implications. DB Leeper, ML Wahl, RA Coss, R Burd, CS Owen, CW Storck. First
International Congress on Stress Responses in Biology and Medicine Quebec City, Quebec, CA.
Miriam L Wahl, PhD
5 Briarfield Court ~ Durham NC 27713
Cell: 443-676-7498 Home: 919-294-9243
Miriam.Wahl@gmail.com
September 10-14, 2003.
10. Angiostatin and Kringle 5 interact with adhesion complexes of the human microvascular
endothelial cells, and alter the phosphorylation of focal adhesion kinase and the cytoskeletal
organization. TA Kalfa, ML Wahl, SV Pizzo, and Yi Zheng. American Society of Pediatric
Hematology-Oncology PAS. 17th Annual Meeting April 29-May 2, 2004; San Francisco, CA.
11. Kringle 5 and angiostatin regulate actin cytoskeleton and focal adhesion of the human
microvascular endothelial cells. TA Kalfa, ML Wahl, SV Pizzo, Y Zheng. The 27th Annual Meeting of
the National Sickle Cell Disease Program, April 18-21, 2004, Los Angeles, California.
12. Ectopic localization of mitochondrial ATP Synthase: A target for anti-angiogenesis intervention? ML
Wahl. FASEB Transport ATPase conference July 16-21, 2005; Vermont Academy, Saxtons River, VT.
13. Resveratrol and Piceatannol: Angiostatin Mimetic Anti-Angiogenic Activity Mediated by ATP
Synthase. TL Holman, RY Strydom, RB Anderson, M Gonzalez-Gronow, DJ Kenan, SV Pizzo, ML
Wahl. Radiation Research/American Society Radiation Oncology Nov 6-9, 2006 Philadelphia, PA.
14. Three new therapeutic targets revealed by experimentation at low tumor-like Extracellular pH. ML
Wahl Invited speaker, The Tumor Microenvironment. 10th International Workshop Sept 15-17
2006, Boston, MA.
15. Targeting Acid Export in Cancer Treatment. ML Wahl. White Oak Seminar Series in Silver Spring
MD. Invited speaker at the FDA April 11, 2007.
16. Targeting Acid Export in Cancer Treatment. ML Wahl. Proton transport and its inhibition in the
etiopathogenesis, diagnosis and treatment of cancer. Invited speaker at International Symposium,
Madrid, Spain April 28-9, 2009.
PROFESSIONAL
Founding Member
Member
Reviewer
Founding Member
Member
Member
Member
Congressional Liaison
Member
Member
Member
ASSOCIATIONS
International Society for Proton Dynamics in Cancer
American Medical Writers Association
For the journals of the Am Assoc for Cancer Research
Society for Melanoma Research
Duke Comprehensive Cancer Center
Duke University Pathology Graduate Faculty
American Association for the Advancement of Science
American Society for Cell Biology
Radiation Research Society
American Association for Cancer Research
American Society for Cell Biology
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