Joseph P. McElroy
Work
The Ohio State University
Center for Biostatistics
2012 Kenny Road
Columbus, OH 43221
Tel: (614) 293-9220
Email:
Joseph.McElroy@osumc.edu
Education
PostdoctoralFellow2011-Current
The Ohio State University
Comprehensive Cancer Center
PostdoctoralResearcher2005-2011
University of California, San Francisco, CA
Department of Neurology
Multiple Sclerosis Genetics
Ph.D. July 2005
Iowa State University, Ames, Iowa
Department of Animal Science
Major: Interdepartmental Genetics
(Specialty: Statistical, Quantitative, and Molecular
Genetics)
Co-Major Professors: Jack. C. M. Dekkers, Susan J. Lamont
Thesis: Mapping QTL for Economic Traits in Chickens.
B.S. May 1998
University of Rio Grande, Rio Grande, Ohio
Majors: Math, Biology; Minors: Chemistry, Physics
Employment
The Ohio State University Center for Biostatistics – Columbus, OH. June 2011 to
present
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Biostatistical Scientist
The Ohio State University Comprehensive Cancer Center – Columbus OH. June 2011
to present
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Postdoctoral fellow with Gustavo Leone. Conduct genomic analyses to
identify cancer related networks and pathways.
University of California, SF – San Francisco, California. October 2005 to May 2011
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Postdoctoral researcher with Dr. Jorge Oksenberg. Utilize genomic analyses
to identify genetic factors affecting multiple sclerosis susceptibility and
severity.
Iowa State University - Ames, Iowa.
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Graduate Research Assistant (August 1998 - July 2005). Conduct poultry
breeding and genome-wide genetic analyses utilizing both quantitative,
statistical, and molecular genetics principals and tools, while working toward
Doctor of Philosophy degree. Dissertation: Mapping quantitative trait loci for
economic traits in chickens.
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Teaching Assistant (Jan 2002 - May 2002). Undergraduate Animal Breeding,
AnSci 352. Enrollment: 25 students. Responsibilities: presenting material,
instructing lab, grading homework
Research Interests
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DNA/RNA sequence analysis
Genome-wide association, CNV, and RNA expression analyses
Experience
Analyses
 Genome-wide association (SNPs, microsatellites, CNVs)
o Data management
o File formatting
o Chip/array QC
o Genotyping QC
o Model development
o Analysis
o Multiple testing correction
o Bioinformatics
o Biological interpretation
o Summary of results (presentation, lay summary, manuscript, tele/video
conference)
 Copy number variation (whole genome)
 DNA sequence
 RNA expression (whole genome)
 Protein expression
 Pathway/Network analyses of genome-wide data and results
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Allele specific expression (whole genome, microarray based)
eQTL/genetical genomics
Candidate gene analysis
Quantitative trait loci analysis (whole genome)
Marker assisted selection
Survival analysis (disease and censored traits)
Line Cross QTL
MAS
Programs
 R/Bioconductor (SNP, CNV, RNA whole genome analyses, data QC)
 Ingenuity Pathway Analysis
 Plink (genome-wide analyses, genetic analyses, data QC)
 JMP Genomics (statistical and genetic analyses, including genome-wide
analyses, data QC)
 Nexus (genome-wide copy number analysis from Biodiscovery)
 Affymetrix Genotyping Console (genotype calling, chip based QC for
genome-wide data)
 Illumina BeadStudio (genotype calling, chip based QC for genome-wide data)
 Haploview (linkage disequilibrium analysis)
 Cytoscape (network analysis of genome-wide SNP, protein, and RNA data)
 Standard MS Windows and Linux programs (data management, displaying
results of analyses, presentations, etc.)
 MS-Dos (batch running of genomic analysis programs)
 Bourne Again Shell (BASH) (batch running of genomic analysis programs,
data management)
Microarray platforms
 Affymetrix
 Illumina
 Agilent
Awards and Honors
T32 fellow in Cancer Genetics, 2011-Present
National MS Society Postdoctoral Research Fellowship, 2008-2010
Professional Advancement Grant, 2003
USDA National Needs International Study and Research Graduate Fellowship, 2002
President- Animal Breeding and Genetics Graduate Student Organization, 2000-2001
USDA Food and Agricultural Sciences National Needs Graduate Fellowship, 1998-2002
Activities
San Carlos Tennis Club, San Carlos CA, 2009-2010
Animal Breeding and Genetics Graduate Student Organization, Iowa State University,
1998-2005.
ISU Boxing Club, Iowa State University 2000-2005 (president, 2002-2003)
Member, American Mensa, 1999-present
Professional Development
Short Courses
Applied Survival Analysis. The Ohio State University, Columbus, OH, 2011.
Design and Economics of Animal Breeding Strategies Short Course. Iowa State
University, Ames, IA. 2003.
Markov Chain Monte Carlo methods for Quantitative Geneticists Short Course. Iowa
State University, Ames, IA. June 2000.
Conference Participation
Conference on New Statistical Methods for Next Generation Sequencing Data
Analysis. Iowa State University. May 11, 2012.
Statistical Analyses for Next Generation Sequencing, Birmingham, AL. 2011.
NMSS Tykeson Fellows Conference. San Antonio, TX. 2010.
NMSS Tykeson Fellows Conference. Chicago, IL. 2008.
Genomics of Common Diseases. Broad Institute. Boston, MA. 2008.
Fishman Symposium UCSF, San Francisco, CA. 2007.
Poultry Science Association, Annual Meeting. Madison, WI. 2003.
John M. Airy Beef Cattle Symposium, Visions for Genetics and Breeding, Johnston, IA.
2003.
American Society of Animal Science, Midwest Section meeting. Des Moines, IA, 2003.
Poultry Breeders of American National Breeders Roundtable. St. Louis, MO, 2001, 2002,
2003, 2004.
Seventh World Congress on Genetics Applied to Livestock Production, Montpellier,
France, 2002.
American Society of Animal Science, Midwest Section meeting. Des Moines, IA, 2000,
2002, 2002.
Plant and Animal Genome VIII. San Diego, CA. 2000.
From Jay L. Lush to Genomics: Visions for Animal Breeding and Genetics. Ames, IA,
1999.
Publications
Refereed Articles
Meng, Wei; McElroy, Joseph; Volinia, Stefano; Palatini, Jeff; Warner, Sarah; Ayers,
Leona; Palanichamy, Kamalakannan; Chakravarti, Arnab; Lautenschlaeger, Tim.
Comparison of MicroRNA deep sequencing of matched formalin-fixed paraffinembedded and fresh frozen cancer tissues. Plos One. Under Revision.
J. P. McElroy, L. Krupp, B. Johnson, J. McCauley, Z. Qi, S. Caillier, P. A. Gourraud, J.
Yu, L. Nathanson, A. Belman, S. Hauser, E. Waubant, D. Hedges, J. Oksenberg. 2012
Copy Number Variation in Pediatric Multiple Sclerosis. Mult. Scler. Dec. 13 [Epub ahead
of print]
McElroy, J. P., Noriko Isobe, Pierre-Antoine F.D. Gourraud, Stacy J. Caillier, Takuya
Matsushita, Tatsuo Kohriyama, Katsuichi Miyamoto, Yuji Nakatsuji, Tetsuro Miki,
Stephen L. Hauser, Jorge R. Oksenberg, and Jun-ichi Kira. 2011. SNP Based Analysis of
the HLA Locus in Japanese Multiple Sclerosis Patients. Genes. Immun. 12(7):523-30.
Gelfand, J. M., B. A. Cree, J. P. McElroy, J. R. Oksenberg, E. Mowry, S. L. Hauser, A.
J. Green. 2011. Vitamin D in African-Americans with Multiple Sclerosis. Neurology
76(21):1824-30.
Gourraud, P. A., J. P. McElroy, S. J. Caillier, B. A. Johnson, A. Santaniello, S. L.
Hauser, J. R. Oksenberg. 2011. Aggregation of MS genetic risk variants in multiple and
single case families. Ann. Neurol 69(1):65-74.
McElroy, J. P. and J. R. Oksenberg. Multiple Sclerosis Genetics 2010. Neurol. Clinics.
29(2):219-31.
Cree, B. A. C., J. D. Rioux, J. L. McCauley, P. A. F. D. Gourraud, P. Goyette, J. P.
McElroy, P. De Jager, A. Santaniello, T. J. Vyse, P. K. Gregersen, D. Mirel, D. A.
Hafler, J. L. Haines, M. A. Pericak-Vance, A. Compston, S. J. Sawcer, J. R. Oksenerg, S.
L. Hauser, IMAGEN, IMSGC. 2010. A Major Histocompatibility Class I Locus
Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01.
Plos One 5: e11296.
McElroy, J. P., B. A. C. Cree, S. J. Caillier, P. K. Gregersen, J. Herbert, O. A. Khan, J.
Freudenberg, A. Lee, S. L. Bridges, Jr., S. L. Hauser, J. R. Oksenberg, and P. A.
Gourraud. 2010. Refining the association of MHC with multiple sclerosis in African
Americans. Hum. Mol. Genet. 19 (15): 3080-8.
Baranzini S. E., J. Mudge, J. C. van Velkinburgh, P. Khankhanian, I. Khrebtukova, N. A.
Miller, L. Zhang, A. D. Farmer, C. J. Bell, R. W. Kim, G. D. May, J. E. Woodward, S. J.
Caillier, J. P. McElroy, R. Gomez, M. J. Pando, L. E. Clendenen, E. E. Ganusova, F. D.
Schilkey, T. Ramaraj, O. A. Khan, J. J. Huntley, S. Luo, P. Y. Kwok, T. D. Wu, G. P.
Schroth, J. R. Oksenberg, S. L. Hauser, and S. F. Kingsmore. 2010. Genome, epigenome
and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature 464:
1351-1356.
McElroy, J. P., M. R. Nelson, S. J. Caillier, and J. R. Oksenberg. 2009. Copy number
variation in African Americans. BMC Genet. 10:15.
McElroy, J. P., and J. R. Oksenberg. 2008. Multiple sclerosis genetics. Curr. Top.
Microbiol. Immunol. 318:45-72.
McElroy, J. P., W. Zhang, K. J. Koehler, S. J. Lamont, and J. C. M. Dekkers. 2006.
Comparison of methods for analysis of selective genotyping survival data. Genetics,
Selection, and Evolution 38(6):637-655.
McElroy, J. P., J.-J. Kim, D. E. Harry, S. Brown, J. C. M. Dekkers, and S. J. Lamont.
2006. Identification of trait loci affecting white meat percent and other growth and
carcass traits in commercial broiler chickens. Poultry Science 85:593–605.
McElroy, J. P., J. C. M. Dekkers, J. E. Fulton, N. P. O'Sullivan, M. Soller, E. Lipkin, W.
Zhang, K. J. Koehler, S. J. Lamont, and H. H. Cheng. 2005. Microsatellite markers
associated with resistance to Marek’s disease in layer chickens. Poultry Science
84:1678–1688.
McElroy, J. P., D. E. Harry, J. C. M. Dekkers, and S. J. Lamont. Molecular markers
associated with growth and carcass traits in meat-type chickens. Proc. 7th World
Congress on Genetics Applied to Livestock Production. Montpelier, France. 2002. Aug.
19-23.
Abstracts
McElroy, J. P., and J. R. Oksenberg. Genetic analysis of multiple sclerosis susceptibility
in African Americans. NMSS Tykeson Fellows Conference. San Antonio, TX. 2010.
McElroy, J. P., S. L. Hauser, B. A. C. Cree, and J. R. Oksenberg. Genome-wide scan
for multiple sclerosis in African Americans. First NMSS Tykeson Fellows Conference.
Chicago, IL. 2008.
McElroy, J. P., S. L. Hauser, and J. R. Oksenberg. Genomic Copy Number Variation in
Multiple Sclerosis. Fishman Symposium UCSF, San Francisco, CA. 2007.
McElroy, J. P., S. Baranzini, and J. R. Oksenberg. Genetic control of differential
transcription between females and males. UCSF Neurology MS Conference. 2006.
McElroy, J. P., J. C. M. Dekkers, J. E. Fulton, N. P. O'Sullivan, M. Soller, E.
Lipkin, W. Zhang, K. J. Koehler, S. J. Lamont, and H. H. Cheng. Microsatellite markers
associated with Marek’s disease survival in commercial layer chickens. The Third
International Symposium on Genetics of Animal Health. 2005.
McElroy, J. P., W. Zhang, K. J. Koehler, S. J. Lamont, and J. C. M. Dekkers.
Comparison of Cox, Weibull, and Linear Regression Models to Detect Marker
Associations with Survival Traits using Full and Selective Genotyping. Plant and Animal
Genome XIII, 2005.
McElroy, J. P., H. H. Cheng, J. Fulton, M. Soller, E. Lipkin, J. C. M. Dekkers,
and S. J. Lamont. Markers Associated with Marek’s Disease Survival in Commercial
Layers. Poultry Science Association 92nd Annual Meeting. P.24, #99.
McElroy, J. P., S. J. Lamont, and J. C. M. Dekkers. Marker Linkage Analysis of
Selective Genotyping Survival Data. The John M. Airy Beef Cattle Symposium: Visions
for Genetics and Breeding. p. 133, #7.
McElroy, J. P., H. Zhou, J. C. M. Dekkers, and S. J. Lamont. Accuracy of DNA Pooling
to Estimate Microsatellite Allele Frequency. J. Anim. Sci. 78, Suppl. 1: 77.
Current Topics of Research
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Genetic Cross-species Ortholog Translation
Weighted Pathway Analysis
Protein Array Binding Analysis
DNA/RNA Sequence Analysis
SNP Imputation
C. elegans RNAi Analysis
Cluster Analysis
Copy Number Variation Analysis
miRNA Seq Analysis