CHEMICAL SAFETY PLAN FOR LABORATORIES
CALIFORNIA STATE POLYTECHNIC UNIVERSITY
POMONA
ENVIRONMENTAL HEALTH AND SAFETY DEPARTMENT
Revised: August 15, 2012
California State Polytechnic University, Pomona
Chemical Safety Plan for Laboratories
Table of Contents
1. AUTHORITY ............................................................................................................................. 1
2. BACKGROUND ......................................................................................................................... 1
3. UNIVERSITY POLICY ............................................................................................................ 2
4. SCOPE AND APPLICATION .................................................................................................. 2
5. OBJECTIVES ........................................................................................................................... 2
6. RESPONSIBILITIES ................................................................................................................ 3
7. ELEMENTS OF THE CHEMICAL SAFETY PLAN FOR LABORATORIES ................. 9
8. STANDARD OPERATING PROCEDURES ....................................................................... 10
9. CRITERIA FOR DETERMINING WHICH CONTROL MEASURES SHALL BE
IMPLEMENTED ......................................................................................................................... 12
1O. MANAGEMENT OF CONTROL MEASURES AND PROTECTIVE EQUIPMENT . 15
11. PRIOR APPROVAL FOR HAZARDOUS OPERATIONS .............................................. 18
12. WORK WITH PARTICULARLY HAZARDOUS CHEMICALS ................................... 21
13. ENVIRONMENTAL MONITORING & EMPLOYEE EXPOSURE ASSESSMENT .. 23
14. EMPLOYEE INFORMATION AND TRAINING ............................................................. 23
15. MEDICAL MONITORING .................................................................................................. 25
16. RECORD KEEPING ............................................................................................................. 26
California State Polytechnic University, Pomona
Chemical Safety Plan for Laboratories
Table of Appendices
Appendix A
Occupational Exposure to Hazardous Chemicals in Laboratories
California Code of Regulations, Title 8, Section 5191……………….28
Appendix B
Laboratory Safety Inspection Checklist ..…………………………….38
Appendix C
Hazard Communication Program Summary………………………….46
Appendix D
Training Documentation Form……………………………………….48
Appendix E
Chemical Donation Procedure……………………………………….50
Appendix F
Chemical Donation Form…………………………………………….52
Appendix G
Standard Operating Procedures and Prior Approval Form …….…….55
Appendix H
Permissible Exposure Limits for Chemical Contaminants
California Code of Regulations, Title 8, Section 5155, Table AC-1...60
Appendix I
Signs and Symptoms of Select Agents and Toxins Used in
Laboratories………………………………………………………….89
Appendix J
Risk Assessment of Work with Toxin and
Determination of Personal Protective Equipment………...………….91
Appendix K
Certification of Annual Review of
Chemical Safety Plan for Laboratories……………………………….93
CALIFORNIA STATE POLYTECHNIC UNIVERSITY, POMONA
CHEMICAL SAFETY PLAN FOR LABORATORIES
1.
AUTHORITY
This Chemical Safety Plan for Laboratories (CSPL) fulfills the requirement of Title 8, California
Code of Regulation, Section 5191. The title of that regulation is “Occupational Exposures to
Hazardous Chemicals in Laboratories” (see Appendix A). The Regulatory Agency responsible
for this regulation is the California Department of Industrial Relations, Division of Occupational
Safety and Health (Cal/OSHA).
2.
BACKGROUND
It is the University's intent that careful attention be given to the health and safety of all
employees and students, and that protection of the environment be maintained. To achieve these
goals, this Chemical Safety Plan for Laboratories provides policies and procedures which are to
be applied in both teaching laboratories and research laboratories.
Also, the CSPL is the University's document which addresses the State of California regulation
concerning exposure to hazardous chemicals in laboratories (Title 8, California Code of
Regulations, Section 5191). This regulation states, for example, in Section 5191(c):
For laboratory uses of Cal/OSHA regulated substances, the employer
shall ensure that laboratory employees' exposures to such substances do
not exceed the exposure limits specified in Title 8, California Code of
Regulations, Group 16, Section 5139 et seq., of the General Industrial
Safety Orders.
The regulation perhaps is best known for its requirement that "all employers engaged in the
laboratory use of hazardous chemicals... shall develop and carry out the provisions of a written
Chemical Hygiene Plan...." (8 CCR 5191(a)(1) and (e)(1)). The Plan must be "capable of
protecting employees from health hazards associated with hazardous chemicals in that
laboratory." (Section 5191(e)(1)(A))
It should be noted that although the term "Chemical Hygiene Plan" is utilized in the regulation,
this term is not used at this University. Instead, it is the Chemical Safety Plan for Laboratories
(CSPL) which is the document fulfilling all requirements specified in the regulation under the
topic "Chemical Hygiene Plan." In addition, the University's CSPL provides comprehensive
coverage of the entire regulation (Section 5191), including several requirements which are not
actually within the Chemical Hygiene Plan subsections of the regulation.
Finally, this CSPL recognizes that effective health and safety practices are closely linked to
chemical management practices which provide maximum protection for the environment.
1
3.
UNIVERSITY POLICY
It is the policy of this University that campus laboratory environments where chemicals are used
and stored, shall be maintained in such a manner that there shall not be adverse health and safety
hazards for University employees, students and visitors. The health and safety of the campus
community shall be given priority during all phases of daily activities. The University also
supports and promotes procedures designed to reduce the impact on the environment of any
hazardous materials used on the campus. To accomplish these goals, the following steps shall be
taken:
4.
A.
The University shall provide facilities and equipment that meet the requirements of
current federal, state and local safety and environmental regulations.
B.
The University shall promulgate written procedures, standards and management plans
which ensure not only compliance with government regulations but also achievement of
University health, safety and environmental goals.
C.
All faculty and staff shall ensure that--within the areas under their control--safe and
healthful conditions are provided and appropriate safety practices are followed. All
members of the campus community shall cooperate fully with all aspects of the various
campus health, safety and environmental programs.
D.
All faculty and staff shall follow established procedures for disposal of chemical,
infectious and radioactive waste, and shall be vigilant in seeking opportunities to reduce
the amount of chemical waste generated in laboratories.
E.
The procedures outlined in this CSPL shall be continuing efforts, not merely short-term
activities.
SCOPE AND APPLICATION
The provisions of this Chemical Safety Plan for Laboratories apply to all personnel who work in
laboratory environments. The provisions of this Plan apply to, but are not necessarily limited to:
faculty; principal investigators; laboratory and stockroom technicians; technical assistants;
student employees; building service engineers; and building trades and maintenance staff.
Although Title 8, CCR 5191 legally applies only to employees, it is the policy of the University
that any student who is present in a laboratory where hazardous chemicals are in use shall receive
appropriate protection from the chemicals and shall be given appropriate training. This includes
students enrolled in a laboratory class, students providing voluntary unpaid assistance to a
faculty or staff member, and students in a laboratory because of a club or other co-curricular
activity.
5.
OBJECTIVES
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The objective of the CSPL is to maintain at lowest possible levels the exposure of employees and
students to hazardous chemicals and to provide guidelines that promote the safe use and storage
of chemicals in laboratories. The CSPL will also serve to establish an effective system for
implementing the following provisions:
A.
Employee and student exposures to hazardous chemicals shall be below the established
Cal/OSHA Permissible Exposure Levels.
B.
The CSPL shall be readily available to all employees and students.
C.
The CSPL shall be reviewed annually.
D.
There shall be regular laboratory inspections and regular maintenance of laboratory
equipment.
E.
There shall be additional controls and employee protection when work with particularly
hazardous chemicals is undertaken.
F.
There shall be an effective employee medical monitoring program.
G.
The responsibility of the Principal Investigators and Laboratory Instructors for
implementation of the CSPL in their laboratories shall be clearly specified.
H.
The responsibility of the Lead Technicians for implementation of the CSPL in the work
areas under their control shall be clearly specified.
I.
There shall be effective health and safety information and training for employees
and students, and appropriate training records shall be maintained.
6.
RESPONSIBILITIES
A.
University Administration
The campus President has ultimate responsibility for establishing and maintaining
effective policies regarding health and safety within the institution. The activities and
responsibilities of the Environmental Health and Safety Programs are thereby established
under the final authority of the President. Departmental managers are responsible for the
implementation of Environmental Health and Safety Programs and shall provide
continuing support.
3
B.
Deans, Directors, Department Chairs, Department Heads
It is the responsibility of the Deans, Directors, Department Chairs, and Department
Heads to develop departmental procedures to ensure effective compliance with the CSPL
and other university health and safety policies as they relate to operations within their
departments. Specifically, these individuals will:
1.
Identify and appoint a Department Safety Coordinator (DSC).
2.
Identify all laboratories in the department.
3.
Identify the Principal Investigators or Course Instructors who are responsible for
each laboratory.
4.
Identify Lead Technicians who are responsible for chemical storage and
handling functions in locations outside the physical boundaries of the actual
teaching and research laboratories.
5.
Ensure that Principle Investigators, Course Instructors and Lead Technicians
have received and completed the required Hazard Communications Training and
the appropriate CSPL Training. The latter shall include requirements for
compliance, elements of the CSPL and specifics regarding the content, methods
and documentation of training to be provided to other employees and to students.
6.
Review the departmental program quarterly, including:
a.
inspection checklists;
b.
accident reports;
c.
Chemical Safety Committee recommendations;
d.
training records;
e.
fiscal prioritization.
7.
Provide avenue for fiscal requests.
8.
Ensure that all chemical inventory procedures are followed.
9.
Provide access to Material Safety Data Sheets (MSDSs) when requested.
10.
Assist Principle Investigators or Course Instructors in identifying laboratory
hazards.
11.
Assist Lead Technicians in identifying hazards in stockrooms or other locations
under their control where chemicals are stored or handled outside the physical
boundaries of the actual teaching and research laboratories.
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12.
C.
Review all Requests for Prior Approval and grant approval when appropriate.
Maintain related records.
Environmental Health and Safety Department (EH&S).
It is the responsibility of EH&S to develop and maintain the CSPL and to monitor
compliance. Further responsibilities are outlined below:
D.
1.
Provide consultation to administrative personnel, Deans, Directors, Department
Chairs, Department Heads and Safety Coordinators regarding program
compliance. Consult and advise on issues of: hazard identification and
evaluation; correction of unsafe conditions; procedures for obtaining fiscal
resources; determining and implementing control measures; employee
information and training programs; and employee medical monitoring.
2.
Provide centralized monitoring of campus-wide chemical safety activities on a
consultative basis.
3.
Maintain centralized copies of records and program documentation.
4.
Maintain current information on legal requirements concerning regulated
substances.
5.
Seek ways to improve the CSPL.
6.
Verify that appropriate audits are conducted. Review and evaluate the
effectiveness of the CSPL and update if necessary.
7.
Designate an EH&S staff member to serve as Chemical Safety Officer.
Chemical Safety Committee
The Chemical Safety Committee shall function as a cooperative effort between colleges
for information dissemination and to ensure that the CSPL procedures are followed. The
Committee shall include a member of the Environmental Health and Safety (EH&S)
Department who will serve as the committee Chairperson. Department Safety
Coordinators appointed to the committee by each department’s Chairperson will makeup the body of the Chemical Safety Committee and will sit as department
representatives. The Committee will support the CSPL with the following
responsibilities:
1.
Submit and prepare agenda items to be discussed at committee meetings.
2.
Assist in dissemination of information and regulatory updates.
3.
Provide recommendations to assist in the evaluation of safety suggestions.
4.
See that appropriate surveys, inventories and training records are maintained.
5
E.
5.
Assist departments in developing procedures and policies for operational use
when necessary.
6.
Review and evaluate various departmental safety concerns and regulatory
deficiencies.
7.
As a committee, collectively prioritize resource allocation to fulfill the safety
needs of the various departments.
8.
Submit these resource prioritization’s through the appropriate channels to ensure
resource allocation.
9.
Seek ways to improve the CSPL.
10.
Meet at least once each quarter or as requested by the CSC Chairperson.
Department Safety Coordinators (DSC)
DSCs are those persons appointed by the Department Chairs or Department Heads to
ensure compliance with regulatory guidelines and CSPL procedures. Responsibilities for
the DSC’s include but are not limited to the following:
1.
Department representative on the Chemical Safety Committee.
2.
Liaison with the EH&S office.
3.
Assist the departments in development and implementation of EH&S programs.
4.
Primary resource person for aiding EH&S activities.
5.
Attend established EH&S Train-the-Trainer Programs.
6.
Ensure that all department surveys and chemical inventories are completed and
returned to the EH&S office in the requested time frame.
7.
Ensure that all copies of the MSDS and training records are forwarded to the
EH&S office for centralized record keeping.
8.
Ensure that all markings, labeling and identifications per regulatory requirements
are in place.
9.
Assist and expedite correction of identified deficiencies.
10.
Ensure that all regulatory information is disseminated.
11.
Provide access to all department employees for safety concerns without fear of
reprisal.
12.
Prepare written reports and recommendations towards improving compliance
with EH&S programs.
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F.
13.
Maintain an up-to-date listing of all Principal Investigators and Course
Instructors who have been designated for laboratory use of chemicals.
14.
Maintain an up-to-date listing of all lead technicians who have been given
responsibility for chemical storage and handling functions in locations outside
the physical boundaries of the actual teaching and research laboratories.
15.
Review and maintain a file of SOPs created in the Department.
16.
Identify and make available SOPs which are appropriate for use as generic SOPs
within the Department.
Principal Investigators (PIs) and Course Instructors
Principal Investigators and Course Instructors are faculty or staff who are responsible for
particular laboratory or research areas. PIs and Course Instructors will have the
following responsibilities:
G.
1.
Implement the CSPL in laboratory areas under their control.
2.
Identify potential laboratory hazards.
3.
Develop site-specific Standard Operating Procedures.
4.
Provide employee training at initial assignment and prior to new exposure
situations.
5.
Maintain training records.
6.
Supervise employees and students to ensure that laboratory safety procedures are
being followed.
7.
Identify materials considered particularly hazardous (including "select
carcinogens," reproductive toxins, and substances which have a high degree of
acute toxicity). Establish designated areas when appropriate. (For definition of
"high degree of acute toxicity," see below, Section 11(A)(5)).
8.
Obtain prior approval from Department Chair for work with particularly
hazardous substances and for work involving any of the other unusual situations
listed in Section 11(A).
9.
Define special circumstances under which employees under their supervision
must request approval before engaging in a given work activity.
Lead Technicians
Lead Technicians are employees who have primary responsibility for certain chemical
storage or handling areas. Lead Technicians will have the following responsibilities:
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H.
1.
Implement the CSPL in areas under their control.
2.
Identify potential chemical hazards.
3.
Develop site-specific Standard Operating Procedures
4.
Provide employee training at initial assignment and prior to new exposure
situations.
5.
Maintain training records.
6.
Supervise employees and students to ensure that laboratory safety procedures are
being followed.
7.
Identify materials considered particularly hazardous (including "select
carcinogens," reproductive toxins, and substances which have a high degree of
acute toxicity). Establish designated areas when appropriate. (For definition of
"high degree of acute toxicity," see below, Section 11(A)(5)).
8.
Obtain prior approval from Department Chair for work with particularly
hazardous substances and for work involving any of the other unusual situations
listed in Section 11(A).
9.
Define special circumstances under which employees under their control must
request approval before engaging in a given work activity.
Laboratory Workers (Instructional Support Technicians, Student Assistants, other
employees)
Any employee who works in a laboratory environment is responsible for the following:
1.
Plan and conduct each operation in accordance with chemical safety procedures
and in accordance with site-specific Standard Operating Procedures.
2.
Use good safety judgment at all times.
3.
Understand and comply with all EH&S programs. Report any significant
problems arising from the implementation of the Standard Operating Procedures
(SOPs), to the PI, Course Instructor or Lead Technician.
8
I.
4.
Report and document all facts pertaining to every accident or "near miss."
Report any action or condition that may exist that could result in an accident.
5.
Attend scheduled education and training sessions.
6.
Ask questions of the PI, Course Instructor or Lead Technician when there is
concern about an unknown or a potentially hazardous situations.
7.
Understand the function and proper use of all personal protective equipment
(PPE). Wear appropriate PPE when required or necessary.
8.
Contact the PI, Course Instructor, Lead Technician and/or EH&S if any of the
above procedures are not clearly understood.
Students
Students are expected to always adhere to safe and healthful work practices defined by
written and oral campus and departmental safety and health guidelines. They must also
report to a responsible party any laboratory hazard that becomes known to them. Failure
to do so will result in the initiation of disciplinary measures.
7.
ELEMENTS OF THE CHEMICAL SAFETY PLAN FOR LABORATORIES
This Chemical Safety Plan for Laboratories addresses the following elements:
A.
Standard Operating Procedures (SOPs) relevant to safety and health which are to be
followed when laboratory work involves the use of hazardous chemicals.
B.
Criteria to be used to determine what control measures are appropriate in order to reduce
employee exposure to hazardous chemicals, particularly chemicals that are extremely
hazardous.
C.
A requirement that fume hoods comply with existing regulations, and that specific
measures be taken to ensure proper and adequate performance of all protective
equipment.
D.
Specification of the circumstances under which a particular laboratory operation,
procedure, or activity will require prior approval from the PI, Course Instructor or Lead
Technician before implementation.
E.
Specification of the circumstances under which a PI, Course Instructor or Lead
Technician must obtain prior approval from the department prior to implementation of a
particular laboratory operation, procedure, or activity.
F.
Personnel responsible for implementation of the CSPL.
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8.
G.
Provisions for work with particularly hazardous substances. These include “select
carcinogens,” reproductive toxins, and substances which have a high degree of acute
toxicity.
H.
Provisions for employee information and training.
STANDARD OPERATING PROCEDURES
A.
Basic Chemical Safety Procedures for Laboratories
The following mandatory safety procedures shall apply in all laboratories where work
with chemicals is conducted. The procedures/rules shall also apply in all chemical
storage/handling areas associated with a university teaching or research laboratory:
1.
Do not taste chemicals or intentionally smell them.
2.
Do not eat, drink, smoke, chew gum or apply cosmetics.
3.
Do not use mouth suction for pipeting or starting a siphon.
4.
Minimize all chemical exposure. Even for substances of no known significant
hazard, exposure should be minimized.
5.
Avoid horseplay or practical jokes which might startle, distract or confuse
another worker.
6.
Wear appropriate eye protection.
7.
Do not wear sandals or open toed shoes.
8.
Use a lab coat or apron to cover legs if you are wearing shorts or a skirt.
9.
Do not store food or beverages in refrigerators or cabinets which are used for
chemicals or laboratory supplies.
10.
Properly secure long hair and loose clothing.
11.
Wear appropriate gloves when the potential for contact with toxic materials
exists.
12.
All aisles and hallways must be kept clear of furniture or other obstructions.
There must be unimpeded access to exits and safety equipment at all times.
13.
When inserting glass tubing into stoppers, lubricate the tubing and protect hands
with a towel or with leather gloves.
10
B.
14.
Check equipment before use, and do not use damaged equipment.
15.
Stored chemicals shall be examined periodically (at least every 6 months) for
replacement, deterioration, container integrity and condition of the label.
16.
Wash hands thoroughly with soap and water after working with chemicals.
17.
Familiarize yourself with the location of safety equipment.
18.
All hazardous chemicals or other hazardous substances shall be transported in
secondary containment that is sufficient to contain any leaks or spills. The use
of a cart for this purpose is standard practice.
Laboratory-Specific Standard Operating Procedures
Principal Investigators, Course Instructors, and Lead Technicians shall evaluate the
chemicals and procedures used in the areas under their control. Based on this evaluation
they shall create a written Standard Operating Procedure which shall be attached to and
become a part of the CSPL for their laboratory. The SOP shall:
1
Provide a clear description of the chemicals that will be used and the procedures
that will be followed.
2.
Provide a logical sequence for workers to follow.
3.
Describe the steps to be taken to minimize the exposure of laboratory workers to
hazardous chemicals. Discuss engineering controls and personal protective
equipment.
4.
Indicate any procedures which require prior approval from the Principal
Investigator.
5.
Describe, where appropriate, special precautions to be used to deal with
particularly hazardous substances.
6.
Take into account the background and experience of the workers who will
conduct a laboratory procedure. Although Departments are encouraged to
develop generic SOPs for certain simple processes, a Principal Investigator,
Course Instructor or Lead Technician may need to provide additional
information in a SOP if workers lack sufficient experience with laboratory
chemicals.
7.
The SOP, together with a copy of the CSPL, shall be readily available in the
applicable laboratory or stock room.
8.
A copy of the SOP shall be provided to the Department Safety Coordinator prior
to the start of the procedure.
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C.
Standard Operating Procedures for Botulinum Neurotoxin are included in the Biosafety
Plan for Clostridium botulinum & Botulinum Neorotoxin.
D.
Sources of Information
A number of sources of information are available for individuals who are preparing
SOPs:
9.
1.
The publication Prudent Practices in the Laboratory (1995) contains 88
Laboratory Chemical Safety Summaries for chemicals ranging from
acetaldehyde and acetic acid to trimethylaluminum and trimethyltin chloride.
The Chemical Safety Summaries include information concerning toxicity,
reactivity, incompatibility, storage, handling, accidents, disposal, etc.
2.
Howard Hughes Medical Institute (http://www.hhmi.org).
3.
The Cal Poly Standard Operating Procedures and Prior Approval Form may be
used as a template (see Appendix G).
4.
The American Chemical Society (http://portal.acs.org)
CRITERIA FOR DETERMINING WHICH CONTROL MEASURES SHALL BE
IMPLEMENTED
A.
Recognition of Potential Hazards
Principal Investigators, Course Instructors and Lead Technicians are responsible for
recognizing potential hazards in work areas under their jurisdiction. This requires
familiarity with the processes and work operations involved, maintenance of an
inventory of the chemicals associated with those processes, and periodic review of the
different research or instructional activities in a work area. Consideration shall be given
to the level of expertise of the individuals working in any area and the level of training
they have received. The basic chemical safety rules required as a Standard Operating
Procedure in all laboratories and storage/handling areas (see above, Section 8(A)) serve
to provide a measure of health and safety protection. However, Principal Investigators,
Course Instructors and Lead Technicians must continually review the types of hazards
created by the chemicals being used and make determinations as to the effectiveness of
existing control measures.
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B.
Hazard Identification
In order to be able to assess hazards, a good system of records is needed to provide
information about all chemicals. Key elements in the system are the following:
1.
Labeling
Principal Investigators, Course Instructors and Lead Technicians will ensure that
labels on newly received containers of hazardous chemicals are not removed or
defaced and that all primary and secondary containers meet the minimum
requirements for labeling as discussed in the Cal Poly Pomona manual
“Employee's Guide To Container Labels.”
2.
Chemical Inventory and Material Safety Data Sheets (MSDSs)
Principal Investigators, Course Instructors and Lead Technicians will be
responsible for maintaining a complete chemical inventory and a file of Material
Safety Data Sheets. MSDSs will be made available to any employee upon
submittal of the Cal Poly MSDS Employee Request Form.
3.
Hazardous Chemicals Produced in the Laboratory
a.
If the chemical composition is known and the chemical is produced
exclusively for the laboratory of origin, the Principal Investigator,
Course Instructor or Lead Technician shall determine if it is hazardous
as defined in Appendix A. If it is a hazardous chemical, the PI, Course
Instructor or Lead Technician shall provide and document training.
b.
If the chemical produced is a by-product with an unknown composition,
the PI, Course Instructor or Lead Technician shall assume that the
substance is a hazardous chemical and shall implement the applicable
sections of the CSPL.
c.
Any chemical substance produced in a chemical laboratory may not be
transferred to a user outside the Department, unless special procedures
are followed. Contact EH&S for assistance in this matter.
d.
Laboratory-prepared solutions of hazardous chemicals must be labeled
with the identity of the chemical and an appropriate health and physical
hazard warning. The identification used shall permit cross-referencing
to the laboratory's MSDS collection.
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C.
Evaluation of Potential Hazards
Departments, in conjunction with Environmental Health and Safety, shall perform
evaluations of the degree of risk arising from exposure to chemical, physical and
biological agents. Risk evaluation involves making judgments based on observations and
detailed measurements of the potential exposure to these agents. Risk evaluation also
involves determining:
D.
E.
1.
Toxicity level and quantity of chemical agents.
2.
Routes of entry.
3.
Possibility of reaction with another agent (either chemical or physical).
4.
Length or duration of exposure.
5.
Airborne concentration levels of air contaminants arising from a process or work
operation.
6.
Effectiveness of any control measures used.
Exposure Control
1.
Exposure levels to hazardous materials shall be kept below the established
Action Levels. In the absence of Action Levels, exposure shall not exceed the
Permissible Exposure Level (PEL). Action level criteria are also provided on the
PEL list. MSDS’s and the Environmental Health and Safety Department can
also provide this information.
2.
Exposure control measures shall be employed by departments to eliminate or
reduce to the lowest practical level, employee exposure to airborne
contaminants. This may be done by one or more of the following types of
control measures.
Types of Control Measures
The following are the three types of mandated control measures. Departments, in
cooperation with the Environmental Health and Safety Department, shall establish
effective and practical exposure control methods based on departmental needs and
regulatory mandates.
1.
Engineering Controls - Methods of controlling employee exposures by reducing
the quantity of contaminants released into the workroom environment (e.g., fume
hoods, glove boxes, local exhaust systems), or by modifying the source (using a
substitute which is less hazardous).
2.
Administrative Controls - Methods of controlling employee exposures to
contaminants by job rotation, work assignment or time periods away from the
contaminant.
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3.
F.
Personal Protective Equipment (PPE) - Includes respirators and other protective
equipment or devices. PPE shall only be considered as a secondary alternative to
the use of engineering and administrative controls.
Selection
Departments, with the assistance of EH&S, shall always attempt to first design safety
into a potentially hazardous process. Only when engineering controls are determined to
be ineffective or impractical shall administrative controls be considered. The use of
Personal Protective Equipment (PPE) to achieve exposure levels below PELs shall be
considered only when all other options have been found to be ineffective or impractical.
G.
Review and Updating
The level of severity of hazards and potential hazards typically changes over time. For
this reason, departments shall continually review, evaluate and update health hazard
control measures.
10.
MANAGEMENT OF CONTROL MEASURES AND PROTECTIVE EQUIPMENT
A.
General Laboratory Ventilation
1.
The University shall provide general chemical laboratory ventilation systems
which are managed to achieve the following:
a.
Compliance with the American Society of Heating Refrigeration and Air
Conditioning Engineers (ASHRAE) Handbook of Fundamental
Guidelines, the Uniform Building Code, and Title 8, California Code of
Regulations, Section 5142.
b.
The system operates continuously during working hours.
c.
The system provides a source of air for breathing and for input to local
ventilation devices.
d.
The general ventilation system is not relied on for protection from toxic
substances released into the laboratory.
e.
Laboratory air is continually replaced, thus preventing a build-up of
toxic or odoriferous air concentrations during the work day. The system
shall provide six (6) to twelve (12) room air changes per hour.
f.
Air pressure in chemical laboratories is negative with respect to the rest
of the building.
15
B.
C.
g.
Air flow is directed into the laboratories from non-laboratory areas. All
air from chemical laboratories is directed out to the exterior of the
building.
h.
Systems are inspected at least annually. Problems found during these
inspections shall be corrected within a reasonable time.
2.
General ventilation shall only be used as method for control of airborne toxic
substances when local exhaust systems are impractical.
3.
General ventilation rates within a given workplace shall be calculated based on
the types and location of air supply vents, location of people in the room, and
relative toxicity of the vapor(s).
Local Exhaust Ventilation
1.
The University shall only use local exhaust ventilation systems when every
effort has been made to control the contaminant by isolation, a change in the
process, or by substitution of a less harmful substance.
2.
Laboratory apparatus that may discharge dangerous levels of toxic vapors, such
as vacuum pump exhausts, gas chromatograph exit ports, and distillation
columns, shall vent to an exhaust device such as a snorkel.
3.
Local exhaust systems shall be utilized for control if:
a.
The contaminant in the atmosphere constitutes a health, fire, or
explosion hazard.
b.
Regulations require local exhaust ventilation for a particular process.
c.
Emission sources are large, few and fixed, or widely dispersed.
d.
Emission sources are near the employee breathing zone.
e.
Emission rates vary widely by time.
Laboratory Fume Hoods
1.
General Guideline for Fume Hood Operation
a.
Fume hood exhaust fans should be kept on at all times when an
experiment is in progress.
b.
All work should be performed by reaching under the sash and keeping
the glass between the worker and the chemical.
c.
Place chemical sources at least 6 inches behind the face of the hood.
16
2.
D.
E.
d.
In order to ensure that air flows easily around all instruments, apparatus
should be separated and elevated.
e.
People should not walk rapidly past a fume hood, as this may create
cross draft.
f.
Fume hoods should have a continuous monitoring device which can be
checked every time the hood is used.
g.
Fumes hoods should not be used for storage of chemicals.
Testing
a.
Fume Hoods shall be tested annually.
b.
In general, the face velocity of a fume hood shall be maintained between
100 and 120 feet per minute.
c.
Proper flow shall be checked using smoke tubes or fog generators.
Flammable Solvent Hazard Control
1.
Departments shall provide for safe handling of flammable liquids, regardless of
the quantities involved. Problems associated with each flammable liquid shall be
analyzed to determine the extent of flammability and health hazards so that
appropriate control measures can be taken.
2.
To control these hazards, departments shall consider the characteristics of the
specific substance in use, the amounts of vapor involved, potential ignition
sources, the kinds of operations, unsafe temperatures, ventilation and type of
building construction.
3.
Departments shall determine the necessity of safeguarding electrical equipment;
ventilation requirements; the need for eliminating sparks, open flames and other
sources of ignition; safe material handling procedures; proper grounding
procedures; and other factors promoting the maintenance of a safe work
environment.
4.
Flammable liquids shall be stored in flammable cabinets when not in use and
always at the end of a work day.
5.
Departments shall obtain and use proper safety devices to protect workers from
the possible hazards associated with flammable liquids.
Emergency Eyewashes and Safety Showers
1.
Location
17
2.
3.
11.
a.
Emergency eyewash facilities and safety showers shall be installed in
easily accessible locations that require no more than 10 seconds for the
injured person to reach.
b.
If both an eyewash and shower are needed, they shall be located so that
an individual can use both at the same time.
c.
The area around the eyewash and shower equipment shall be maintained
free of items which could obstruct their use.
Performance
a.
The control valve shall be designed so that the water flow remains on
without requiring the use of the operator's hands, and so that the valve
remains activated until intentionally shut off,
b.
Personal eyewash units shall deliver tempered clean potable water or an
approved eye-flushing solution for a minimum of 15 minutes
continuously.
Maintenance
a.
Eyewash and shower equipment shall be activated by Department Safety
Coordinator or designee at least monthly to flush the line and to verify
proper operation.
b.
Other units shall be maintained in accordance with the manufacturers
instructions.
PRIOR APPROVAL FOR HAZARDOUS OPERATIONS
A.
Prior Approval by the Department Chairperson or Department Head.
Occasionally, a particular laboratory operation, procedure, or activity will require prior
approval. The Principal Investigator, Course Instructor or Lead Technician shall obtain
approval from the Department Chairperson or Department Head. The following are
examples of circumstances that will require such approval. Circumstances are not
limited to these examples:
1.
When the likelihood of exceeding the Action levels or PEL is suspected, or is
indicated during the Evaluation of Potential Hazards process (see above, Section
9(c)).
2.
Whenever work will be performed outside the normal operating hours of the
laboratory.
3.
Whenever experiments will involve one person working alone. If an experiment
is known to be hazardous, it may not be conducted by one person working alone;
18
however, permission may be granted for less dangerous work, provided a
Principal Investigator establishes procedures for the lone worker to be checked
on periodically.
4.
Whenever operations with hazardous chemicals will take place when no one is
present. For such operations, appropriate signs must be posted and laboratory
lights must be left on. Precautions must be taken to ensure that no hazardous
chemicals will be released if utility service should fail.
5.
Whenever an experiment involves a highly toxic substance. A "highly toxic
substance" is defined as one which falls into any of the following categories:
a.
A substance that has a median lethal dose (LD50) of 50 milligrams or
less per kilogram of body weight when administered orally to albino rats
weighing between 200 and 300 grams each.
b.
A substance that has a median lethal dose (LD50) of 200 milligrams or
less per kilogram of body weight when administered by continuous
contact for 24 hours (or less if death occurs within 24 hours) with the
bare skin of albino rabbits weighing between two and three kilograms
each.
A substance that has a median lethal concentration (LC50) in air of 200
parts per million by volume or less of gas or vapor, or 2 milligrams per
liter or less of mist, fume, or dust, when administered by continuous
inhalation for one hour (or less if death occurs within one hour) to albino
rats weighing between 200 and 300 grams each. (8 CCR, Appendix to
Section 5194)
c.
B.
Approval Procedure
1.
The request for approval shall be made by submitting a proposal to the
Department Chair/Head for review with a copy to EH&S. A Department may
elect to have a preliminary review carried out by the DSC who will forward the
request to the Chair.
2.
The proposal shall include the following:
a.
Description of the project, process or test.
b.
Hazardous materials that will be used (MSDSs for each material).
19
C.
c.
Specification of the safety precautions to be used at each step of the
process.
d.
Possible exposure hazards.
e.
Control measures utilized (engineering, administrative or personal
protective equipment)
f.
Flow sheet of the process showing the substances and equipment that
will be used.
g.
The proposed handling procedure of the products, by-products, and
waste material.
h.
Location and expected duration of the project, process or test.
3.
The request shall be made using the Prior Approval Form (Appendix G);
additional pages may be attached if necessary.
4.
If the required description of Standard Operating Procedures (see above, Section
8) has already been prepared, that document may contain most of the information
needed in the application for prior approval.
5.
If the project or process is approved, a copy of the Prior Approval Form
containing the signature of the Chair shall be kept in the applicable laboratory
together with the CSPL and the SOP.
6.
If the project or process is approved, the project requester and Department
Chair/Head shall meet to ensure that all hazards, prescribed safety procedures
and control measures of the project are known. The project requester and/or PI
shall ensure workplace controls are in place prior to starting a new procedure. If
there is a potential for an employee exposure, monitoring shall be conducted in
the beginning phases of the new procedure to ensure exposures are below PELs.
Employee exposure monitoring data will be performed by EH&S and made
readily available to the employees being monitored.
7.
Prior approval by the Chair is granted for a maximum of 3 months (90 days).
Prior Approval to Be Obtained from the Principal Investigator, Course Instructor or Lead
Technician
In preparing Standard Operating Procedures, Principal Investigators, Course Instructors
and Lead Technicians shall specify any circumstances under which the workers they are
supervising must obtain prior approval.
20
D.
Departmental Review of an Existing Program
In order that appropriate departmental review of on-going programs may occur,
notification in writing to the Department Chairperson or Department Head shall be made
concerning any newly identified or suspected hazards. Laboratory related injuries or
illnesses are also reportable. Follow notification procedures described on the hazard
communications poster, and send copies to EH&S. The following are situations where
Departmental review shall be conducted:
12.
1.
Whenever there is a change in toxicological data (resulting in an increased
hazard potential).
2.
When an injury or illness has occurred as a result of a new process, product, or
procedure, or due to an exposure to a hazardous chemical.
3.
When faculty, staff or others have been accidentally exposed to a hazardous
chemical, or otherwise suspect ineffective or inappropriate safeguards.
4.
Whenever an existing (previously unidentified) hazard is discovered or
suspected.
WORK WITH PARTICULARLY HAZARDOUS CHEMICALS
Departments shall follow special procedures when performing laboratory work with particularly
hazardous substances, including “select carcinogens,” reproductive toxins, and substances which
have a high degree of acute toxicity. (Special control measures are also in place on this campus
for radioactive materials; these are found in the Radiation Safety Manual, California State
Polytechnic University, Pomona) Work with particularly hazardous chemicals requires that the
following provisions be considered and included where appropriate:
A.
Careful planning shall precede any work with high toxicity substances.
1.
A determination shall be made as to special requirements, such as training or
documentation, that may be required by state or federal regulations.
2.
The experiment plan shall be reviewed by experienced personnel.
3.
Consideration shall be given to reducing risk by substitution of a less toxic
substance and by using the smallest amount of a substance that is practical.
4.
Planning shall include methods for managing a substance throughout its entire
life cycle, from acquisition and storage through eventual safe disposal.
21
B.
Designated areas shall be established, and work with highly toxic chemicals shall be
restricted to these areas.
1.
These areas must be a restricted access hood, glove box, or portion of a
laboratory designated for use of the particularly hazardous substances.
2.
Designated areas shall be clearly indicated by signage, and the boundaries of
such areas shall be clearly marked.
3.
Access to these areas shall be allowed only to persons who are directly involved
in the laboratory work and who have been informed of the special precautions
required. Only those persons with demonstrated knowledge and ability to work
with particularly hazardous substances shall work with chemicals in the
designated area.
C.
Containment devices, such as fume hoods or glove boxes, shall be used when handling
particularly hazardous chemicals which are volatile; when procedures involve
manipulations that may result in the generation of an aerosol or airborne dust; and with
any manipulation, handling, or reaction that may result in the uncontrollable release of
the substance.
D.
Special consideration shall be given to planning for accidents and spills. Emergency
response procedures may be the last line of defense when working with highly toxic
chemicals.
1.
Laboratory workers should be trained in the use of spill control and emergency
response kits.
2.
Emergency response kits should not be stored within the immediate area where a
highly toxic substance is being handled. Otherwise, the equipment could be
inaccessible or contaminated in case of an accident.
3.
Prior to the start of an experiment, the contents of the emergency response kit
should be verified.
E.
Decontamination procedures shall be designed based on laboratory circumstances.
F.
Removal of contaminated wastes shall involve approved safety procedure.
22
13.
ENVIRONMENTAL MONITORING AND EMPLOYEE EXPOSURE ASSESSMENT
A.
Environmental Monitoring
Regular monitoring of airborne chemical concentrations is not usually justified or
practical in laboratories because chemicals are used for short periods of time and in
small quantities. However, monitoring may be appropriate when testing or redesigning
hoods or other ventilation devices, or when a highly toxic or hazardous substance is
stored or used regularly.
B.
14.
Exposure Assessment
1.
Monitoring needs will be identified by the department during laboratory safety
inspections or when a Request for Prior Approval is received from a Principal
Investigator or Laboratory Instructor. In addition, if there is a risk or concern of
potential employee overexposure, departments will evaluate potential exposures
on a case by case basis.
2.
When an exposure risk is identified or suspected, notification shall be made to
the Environmental Health and Safety Department which will employ
appropriately approved industrial hygiene practices and procedures to assess the
level of airborne chemical concentrations.
EMPLOYEE INFORMATION AND TRAINING
A.
Frequency of Training
Employees shall be informed and trained on the hazards of chemicals present in the work
area. Such information shall be provided at the time of an employee's initial assignment
to a work area where hazardous chemicals are present, prior to starting a new assignment
involving previously unused hazardous chemicals, or when work is commenced in an
unfamiliar laboratory environment or with unfamiliar procedures.
B.
Employee Information
Employees shall be informed of the following:
1.
The contents of the CSPL and its appendices, which shall be made available to
all employees.
2.
The location and availability of the CSPL.
a.
Master copies of the CSPL will be kept by the Deans, Directors,
Department Chairs and Department Heads responsible for laboratory
areas, and at EH&S.
23
C.
b.
The CSPL will be available for review during normal work hours, and
additional copies may be distributed to employees as appropriate.
c.
A copy of the CSPL shall be kept in each laboratory or stock room
together with the SOP for that laboratory. In teaching the case of
laboratories, the CSPL may be kept in the Department office.
3.
The contents of Title 8 of the California Code of Regulations, Section 5191.
4.
The exposure limits for Cal/OSHA regulated substances, or the recommended
exposure limits for other hazardous chemicals where there is no applicable
Cal/OSHA regulation. The following reference sources can be used to obtain
this information:
a.
Cal/OSHA Airborne Contaminants (see Appendix H).
b.
American Conference of Governmental Industrial Hygienists, Threshold
Limit Values {ACGIH, TLVs} (Contact Environmental Health & Safety
for access to a copy of this publication).
c.
Material Safety Data Sheets (Obtain directly from Manufacurer or
Contact Environmental Health & Safety).
d.
Environmental Health and Safety Department.
5.
Signs and symptoms associated with exposures to hazardous chemicals used in
the laboratory. This information can be found in the MSDSs for the chemical(s)
in use. Additionally, the Signs and symptoms associated with exposures to some
select agents and Toxins are available in Appendix J of this plan.
6.
The location and availability of known reference materials on the hazards, safe
handling, storage and disposal of hazardous chemicals, including, but not limited
to, MSDSs received from the chemical supplier.
Employee Training
Employee Training should be initiated at the time of an employee's initial assignment to
a work area where hazardous chemicals are present, and prior to an assignment which
involves a new type of chemical exposure. Employee training shall include:
1.
Methods and observations that may be used to detect the presence or release of a
hazardous chemical (i.e. continuous monitoring devices, visual appearance or
odor of hazardous chemicals, etc.). These methods and observations are listed
below:
Methods and Observation to Detect the Presence of a Spill or
Release of Botulinum Toxin
 The presence of broken containers.
 The presence of overturned containers with missing lids
24




15.
The presence of a somewhat reflective clear film on cabinets,
counters or other equipment, etc.
The presence of a rotten garbage smell which is a description of the
odor of Clostridium Botulinum bacteria which may be presence in
some samples of Botulinum.
The presence of any strange or unusual odor.
The presence of a color or odor matching the information for a
particular hazardous substance (Refer to Material Safety Date
Sheet).
2.
The physical and health hazards of chemicals in the work area.
3.
The methods of protection from potential hazards, including specific University,
campus, or departmental procedures that have been implemented to protect
employees from exposure to hazardous chemicals (i.e. appropriate work
practices, emergency procedures, personal protective equipment, etc.).
4.
The Standard Operating Procedures which have been developed for the
particular laboratory in which the employee will be working.
5.
Whenever employees are trained, records shall be kept to document that this
training has occurred. The Training Documentation Form (Appendix D) shall be
used for this purpose.
MEDICAL MONITORING
A.
The University Medical Monitoring Program is designed to assist in the maintenance of
employee health and to ascertain the effectiveness of hazard control methods. Certain
laboratory workers who work with hazardous chemicals shall be provided an opportunity
to receive medical consultation and examination. Employees who meet specific criteria
shall be provided with appropriate medical consultation and exams at no cost to the
employees, without loss of pay, and at a reasonable time and place. The circumstances
under which medical consultation for an employee may be appropriate include the
following:
1.
Whenever an employee develops signs or symptoms associated with a hazardous
chemical to which the employee may have been exposed in the laboratory.
2.
Whenever exposure monitoring reveals an exposure level above the action level
(or in the absence of an action level, the exposure limit) for a Cal/OSHA
regulated substance for which there are exposure monitoring and medical
surveillance requirements. In such circumstances, medical surveillance shall be
established for the affected employee as prescribed by the particular standard.
3.
Whenever an event takes place in the work area, such as a spill, leak, explosion
or other occurrence resulting in the likelihood of a hazardous exposure. In such
circumstances, consultation with a physician shall be for the purpose of
determining the need for a medical examination.
25
B.
Information Provided to Physician
The following information shall be provided to the physician:
C.
1.
The identity of the hazardous chemical(s) to which the employee may have been
exposed.
2.
A copy of the MSDS for the chemical to which the employee may have been
exposed.
3.
A description of the conditions under which the exposure occurred, including
quantitative exposure data, if available.
4.
A description of the signs and symptoms of exposure that the employee is
experiencing, if any.
Physician's Written Opinion
1.
2.
16.
A written report from the physician to whom the employee was referred, must be
provided to the of Environmental Health and Safety Department. The report
shall include the following:
a.
Any recommendation for further medical follow-up.
b.
The results of the medical examination and any associated tests, if
requested by the employee.
c.
Any medical condition which may be revealed in the course of the
examination which may place the employee at increased risk as a result
of exposure to a hazardous chemical found in the workplace.
d.
A statement that the employee has been informed by the physician of the
results of the consultation or medical examination and any medical
condition that may require further examination or treatment.
The written opinion shall not reveal any specific findings or diagnoses unrelated
to the hazardous exposure.
RECORD KEEPING
A.
Records related to occupational injuries and illnesses, exposure monitoring, inspections
and other activities and incidents relevant to occupational health and safety shall be kept
by EH&S and individual departments. Detailed responsibilities and procedures are
contained in the University IIPP Policy.
B.
Where medical monitoring is required, individual medical surveillance records shall be
kept by EH&S and are subject to strict privacy regulations. Access to these records by
26
departmental committees, designated PIs, course instructors, or anyone else other than
the employee can only be done with a written approval by the employee. Written record
access approvals are subject to verification prior to release of documents. Employees
requesting copies of these records must provide appropriate identification.
27
APPENDIX A
Occupational Exposure to Hazardous Chemicals in Laboratories
California Code of Regulations, Title 8, Section 5191
28
§5191.
Title 8, CCR
Occupational Exposure to Hazardous Chemicals in Laboratories
(a) Scope and application.
(1) This section shall apply to all employers engaged in the laboratory use of hazardous
chemicals as defined below.
(2) Where this section applies, it shall supersede, for laboratories, the requirements of Title 8 of
the California Code of Regulations Section 5190 and Article 110, Regulated Carcinogens of the General
Industry Safety Orders, except as follows:
(A) The requirement to limit employee exposure to the specific exposure limit.
(B) When that particular regulation states otherwise, as in the case of Section 5209(c)(6).
(C) Prohibition or prevention of eye and skin contact where specified by any health regulation
shall be observed.
(D) Where the action level (or in the absence of an action level, the exposure limit) is exceeded
for a regulated substance with exposure monitoring and medical surveillance requirements.
(E) The "report of use" requirements of Article 110, (Section 5200 et. seq.) Regulated
Carcinogens regulations.
(F) Section 5217 shall apply to anatomy, histology and pathology laboratories.
(3) This regulation shall not apply to:
(A) Uses of hazardous chemicals which do not meet the definition of laboratory use, and in such
cases, the employer shall comply with the relevant regulations in Title 8, California Code of Regulations,
even if such use occurs in a laboratory.
(B) Laboratory uses of hazardous chemicals which provide no potential for employee exposure.
Examples of such conditions might include:
1. Procedures using chemically-impregnated test media such as Dip-and-Read tests where a
reagent strip is dipped into the specimen to be tested and the results are interpreted by comparing the
color reaction to a color chart supplied by the manufacturer of the test strip; and
2. Commercially prepared kits such as those used in performing pregnancy tests in which all of
the reagents needed to conduct the test are contained in the kit.
(b) Definitions
Action level. A concentration designated in Title 8, California Code of Regulations for a specific
substance, calculated as an eight (8)-hour time weighted average, which initiates certain required
activities such as exposure monitoring and medical surveillance.
Carcinogen (see "select carcinogen").
Chemical Hygiene Officer. An employee who is designated by the employer, and who is qualified by
training or experience, to provide technical guidance in the development and implementation of the
provisions of the Chemical Hygiene Plan. This definition is not intended to place limitations on the
position description or job classification that the designated individual shall hold within the employer's
organizational structure.
29
§5191.
Title 8, CCR
Chemical Hygiene Plan. A written program developed and implemented by the employer which sets forth
procedures, equipment, personal protective equipment and work practices that
(1) are capable of protecting employees from the health hazards presented by hazardous
chemicals used in that particular work place and
(2) meets the requirements of subsection 5191(e).
Chief. The Chief of the Division of Occupational Safety and Health.
Combustible liquid. Any liquid having a flash point at or above 100 o F (37.8 o C), but below 200 o F
(93.3 o C) except any mixture having components with flash points of 200 o F (93.3 o C), or higher, the
total volume of which make up 99 percent or more of the total volume of the mixture.
Compressed gas.
(1) A gas or mixture of gases having, in a container, an absolute pressure exceeding 40 psi at 70o
o
F (21.1 C); or
(2) A gas or mixture of gases having, in a container, an absolute pressure exceeding 104 psi at
o
130 F (54.4o C) regardless of the pressure at 70o F (21.1o C); or
(3) A liquid having a vapor pressure exceeding 40 psi at 100o F (37.8o C) as determined by
ASTM D-323-72.
Designated area. An area which may be used for work with "select carcinogens," reproductive toxins or
substances which have a high degree of acute toxicity. A designated area may be the entire laboratory, an
area of a laboratory or a device such as a laboratory hood.
Emergency. Any occurrence such as, but not limited to, equipment failure, rupture of containers or
failure of control equipment which results in an uncontrolled release of a hazardous chemical into the
workplace.
Employee. An individual employed in a laboratory workplace who may be exposed to hazardous
chemicals in the course of his or her assignments.
Explosive. A chemical that causes a sudden, almost instantaneous release of pressure, gas, and heat when
subjected to sudden shock, pressure, or high temperature.
Flammable. A chemical that falls into one of the following categories:
(1) "Aerosol, flammable" means an aerosol that, when tested by the method described in 16 CFR
1500.45, yields a flame projection exceeding 18 inches at full valve opening, or a flashback (a flame
extending back to the valve) at any degree of valve opening;
(2) "Gas, flammable" means:
(A) A gas that, at ambient temperature and pressure, forms a flammable mixture with air at a
concentration of 13 percent by volume or less; or
(B) A gas that, at ambient temperature and pressure, forms a range of flammable mixtures with
air greater than 12 percent by volume, regardless of the lower explosive limit.
(3) "Liquid, flammable" means any liquid having a flash point below 100o F (37.8o C), except
any mixture having components with flash points of 100o F (37.8o C) or higher, the total of which make
up 99 percent or more of the total volume of the mixture.
30
§5191.
Title 8, CCR
(4) "Solid, flammable" means a solid, other than a blasting agent or explosive as defined in 29
CFR 1910.109(a), that is liable to cause fire through friction, absorption of moisture, spontaneous
chemical change, or retained heat from manufacturing or processing, or which can be ignited readily and
when ignited burns so vigorously and persistently as to create a serious hazard. A chemical shall be
considered to be a flammable solid if, when tested by the method described in 16 CFR 1500.44, it ignites
and burns with a self-sustained flame at a rate greater than one-tenth of an inch per second along its
major axis.
Flashpoint. The minimum temperature at which a liquid gives off a vapor in sufficient concentration to
ignite when tested as follows:
(1) Tagliabue Closed Tester (See American National Standard Method of Test for Flash Point by
Tag Closed Tester, Z11.24 - 1979 (ASTM D 56-79) - for liquids with a viscosity of less than 45 Saybolt
Universal Seconds (SUS) at 100 o F (37.8 o C), or that do not contain suspended solids, and do not have
a tendency to form a surface film under test; or
(2) Pensky-Martens Closed Tester (see American National Standard Method of Test for Flash
Point by Pensky-Martens closed tester), Z11.7 - 1979 (ASTM D 93-79) for liquids with a viscosity equal
to or greater than 45 SUS at 100 o F (37.8 o C), or that contain suspended solids, or that have a tendency
to form a surface film under test; or
(3) Setaflash Closed Tester (see American National Standard Method of Test for Flash Point by
Setaflash Closed Tester (ASTM D 3278-78)). Organic peroxides, which undergo auto-accelerating
thermal decomposition, are excluded from any of the flash point determination methods specified above.
Hazardous chemical. A chemical for which there is statistically significant evidence based on at least one
study conducted in accordance with established scientific principles that acute or chronic health effects
may occur in exposed employees. The term "health hazard" includes chemicals which are carcinogens,
toxic or highly toxic agents, reproductive toxins, irritants, corrosives, sensitizers, hepatotoxins,
nephrotoxins, neurotoxins, agents which act on the hematopoietic systems, and agents which damage the
lungs, skin, eyes, or mucous membranes. Appendices A and B of the Hazard Communication Standard
(Section 5194) provide further guidance in defining the scope of health hazards and determining whether
or not a chemical is to be considered hazardous for purposes of this regulation.
Laboratory. A facility where the "laboratory use of hazardous chemicals" occurs. It is a workplace where
relatively small quantities of hazardous chemicals are used on a non-production basis.
Laboratory scale. Work with substances in which the containers used for reactions, transfers, and other
handling of substances are designed to be easily and safely manipulated by one person. "Laboratory
scale" excludes those workplaces whose function is to produce commercial quantities of materials.
Laboratory-type hood. A device located in a laboratory, enclosed on five sides with a movable sash or
fixed partial enclosure on the remaining side; constructed and maintained to draw air from the laboratory
and to prevent or minimize the escape of air contaminants
31
§5191.
Title 8, CCR
into the laboratory; and allows chemical manipulations to be conducted in the enclosure without insertion
of any portion of the employee's body other than hands and arms.
Walk-in hoods with adjustable sashes meet the above definition provided that the sashes are adjusted
during use so that the airflow and the exhaust of air contaminants are not compromised and employees do
not work inside the enclosure during the release of airborne hazardous chemicals.
Laboratory use of hazardous chemicals. Handling or use of such chemicals in which all of the following
conditions are met:
(1) Chemical manipulations are carried out on a "laboratory scale";
(2) Multiple chemical procedures or chemicals are used;
(3) The procedures involved are not part of a production process, nor in any way simulate a
production process; and
(4) "Protective laboratory practices and equipment" are available and in common use industry-wide
to minimize the potential for employee exposure to hazardous chemicals.
Medical consultation. A consultation which takes place between an employee and a licensed physician
for the purpose of determining what medical examinations or procedures, if any, are appropriate in cases
where a significant exposure to a hazardous chemical may have taken place.
Organic peroxide. An organic compound that contains the bivalent -o-o- structure and which may be
considered to be a structural derivative of hydrogen peroxide where one or both of the hydrogen atoms
has been replaced by an organic radical.
Oxidizer. A chemical other than a blasting agent or explosive as defined in Section 5237(a), that initiates
or promotes combustion in other materials, thereby causing fire either of itself or through the release of
oxygen or other gases.
Physical hazard. A chemical for which there is scientifically valid evidence that it is a combustible liquid,
a compressed gas, explosive, flammable, an organic peroxide, an oxidizer, pyrophoric, unstable (reactive)
or water-reactive.
Protective laboratory practices and equipment. Those laboratory procedures, practices and equipment
accepted by laboratory health and safety experts as effective, or that the employer can show to be
effective, in minimizing the potential for employee exposure to hazardous chemicals.
Reproductive toxins. Chemicals which affect the reproductive capabilities including chromosomal
damage (mutations) and effects on fetuses (teratogenesis).
Select carcinogen. Any substance which meets one of the following criteria:
(1) It is regulated by Cal/OSHA as a carcinogen; or
(2) It is listed under the category, "known to be carcinogens," in the Annual Report on
Carcinogens published by the National Toxicology Program (NTP) (1985 edition); or
(3) It is listed under Group 1 ("carcinogenic to humans") by the International Agency for
Research on Cancer Monographs (IARC) (Volumes 1-48 and Supplements 1-8); or
32
§5191.
Title 8, CCR
(4) It is listed in either Group 2A or 2B by IARC or under the category, "reasonably anticipated
to be carcinogens" by NTP, and causes statistically significant tumor incidence in experimental animals
in accordance with any of the following criteria:
(A) After inhalation exposure of 6-7 hours per day, 5 days per week, for a significant portion of a
lifetime to dosages of less than 10 mg/m 3 ;
(B) After repeated skin application of less than 300 mg/kg of body weight per week; or
(C) After oral dosages of less than 50 mg/kg of body weight per day.
Unstable (reactive). A chemical which is the pure state, or as produced or transported, will vigorously
polymerize, decompose, condense, or will become self-reactive under conditions of shocks, pressure or
temperature.
Water-reactive. A chemical that reacts with water to release a gas that is either flammable or presents a
health hazard.
(c) Exposure limits. For laboratory uses of Cal/OSHA regulated substances, the employer shall
ensure that laboratory employees' exposures to such substances do not exceed the exposure limits
specified in Title 8, California Code of Regulations, Group 16, Section 5139 et seq., of the General
Industry Safety Orders.
(d) Employee exposure determination
(1) Initial monitoring. The employer shall measure the employee's exposure to any substance
regulated by a standard which requires monitoring if there is reason to believe that exposure levels for
that substance exceed the action level (or in the absence of an action level, the exposure limit). The
person supervising, directing or evaluating the monitoring shall be competent in industrial hygiene
practice.
(2) Periodic monitoring. If the initial monitoring prescribed by subsection 5191(d)(1) discloses
employee exposure over the action level (or in the absence of an action level, the exposure limit), the
employer shall immediately comply with the exposure monitoring provisions of the relevant regulation.
(3) Termination of monitoring. Monitoring may be terminated in accordance with the relevant
regulation.
(4) Employee notification of monitoring results. The employer shall, within 15 working days
after the receipt of any monitoring results, notify the employee of these results in writing either
individually or by posting results in an appropriate location that is accessible to employees.
(e) Chemical hygiene plan.
(1) Where hazardous chemicals as defined by this regulation are used in the workplace, the
employer shall develop and carry out the provisions of a written Chemical Hygiene Plan which is:
(A) Capable of protecting employees from health hazards associated with hazardous chemicals in
that laboratory and
(B) Capable of keeping exposures below the limits specified in subsection 5191(c).
(2) The Chemical Hygiene Plan shall be readily available to employees. employee
representatives and, upon request, to the Chief.
33
§5191.
Title 8, CCR
(3) The Chemical Hygiene Plan shall include each of the following elements and shall indicate
specific measures that the employer will take to ensure laboratory employee protection;
(A) Standard operating procedures relevant to safety and health considerations to be followed
when laboratory work involves the use of hazardous chemicals:
(B) Criteria that the employer will use to determine and implement control measures to reduce
employee exposure to hazardous chemicals including engineering controls, the use of personal protective
equipment and hygiene practices; particular attention shall be given to the selection of control measures
for chemicals that are known to be extremely hazardous;
(C) A requirement that fume hoods comply with Section 5154.1, that all protective equipment
shall function properly and that specific measures shall be taken to ensure proper and adequate
performance of such equipment;
(D) Provisions for employee information and training as prescribed in subsection 5191(f);
(E) The circumstances under which a particular laboratory operation, procedure or activity shall
require prior approval from the employer or the employer's designee before implementation;
(F) Provisions for medical consultation and medical examinations in accordance with subsection
5191(g);
(G) Designation of personnel responsible for implementation of the Chemical Hygiene Plan
including the assignment of a Chemical Hygiene officer and, if appropriate, establishment of a Chemical
Hygiene Committee; and
(H) Provisions for additional employee protection for work with particularly hazardous
substances. These include "select carcinogens," reproductive toxins and substances which have a high
degree of acute toxicity. Specific consideration shall be given to the following provisions which shall be
included where appropriate;
1. Establishment of a designated area;
2. Use of containment devices such as fume hoods or glove boxes;
3. Procedures for safe removal of contaminated waste; and
4. Decontamination procedures.
(4) The employer shall review and evaluate the effectiveness of the Chemical Hygiene Plan at
least annually and update it as necessary.
Appendix A of this section is non-mandatory but provides guidance to assist employers in the
development of the Chemical Hygiene Plan.
(f) Employee information and training.
(1) The employer shall provide employees with information and training to ensure that they are
apprised of the hazards of chemicals present in their work area. Information and training may relate to an
entire class of hazardous substances to the extent appropriate.
(2) Such information shall be provided at the time of an employee's initial assignment to a work
area where hazardous chemicals are present and prior to
34
§5191.
Title 8, CCR
assignments involving new exposure situations. The frequency of refresher information and training shall
be determined by the employer.
(3) Information. Employees shall be informed of:
(A) The contents of this regulation and its appendices which shall be available to employees;
(B) The location and availability of the employer's Chemical Hygiene Plan;
(C) The exposure limits for Cal/OSHA regulated substances or recommended exposure limits for
other hazardous chemicals where there is no applicable Cal/OSHA regulation;
(D) Signs and symptoms associated with exposures to hazardous chemicals used in the
laboratory; and
(E) The location and availability of known reference material on the hazards, safe handling,
storage and disposal of hazardous chemicals found in the laboratory including, but not limited to,
Material Safety Data Sheets received from the chemical supplier.
(4) Training.
(A) Employee training shall include;
1. Methods and observations that may be used to detect the presence or release of a hazardous
chemical (such as monitoring conducted by the employer, continuous monitoring devices, visual
appearance or odor of hazardous chemicals when being released, etc.);
2. The physical and health hazards of chemicals in the work area; and
3. The measures employees can take to protect themselves from these hazards, including specific
procedures the employer has implemented to protect employees from exposure to hazardous chemicals,
such as appropriate work practices, emergency procedures, and personal protective equipment to be used.
(B) The employee shall be trained on the applicable details of the employer's written Chemical
Hygiene Plan.
(g) Medical consultation and medical examinations.
(1) The employer shall provide all employees who work with hazardous chemicals an
opportunity to receive medical attention, including any follow-up examinations which the examining
physician determines to be necessary, under the following circumstances;
(A) Whenever an employee develops signs or symptoms associated with a hazardous chemical to
which the employee may have been exposed in the laboratory, the employee shall be provided an
opportunity to receive an appropriate medical examination.
(B) Where exposure monitoring reveals an exposure level above the action level (or in the
absence of an action level, the exposure limit) for a Cal/OSHA regulated substance for which there are
exposure monitoring and medical surveillance requirements, medical surveillance shall be established for
the affected employee as prescribed by the particular standard.
(C) Whenever an event takes place in the work area such as a spill, leak, explosion or other
occurrence resulting in the likelihood of a hazardous exposure, the affected employee shall be provided
an opportunity for a medical consultation. Such consultation shall be for the purpose of determining the
need for a medical examination.
35
§5191.
Title 8, CCR
(2) All medical examinations and consultations shall be performed by or under the direct
supervision of a licensed physician and shall be provided without cost to the employee, without loss of
pay and at a reasonable time and place.
(3) Information provided to the physician. The employer shall provide the following information
to the physician;
(A) The identity of the hazardous chemical(s) to which the employee may have been exposed;
(B) A description of the conditions under which the exposure occurred including quantitative
exposure data, if available; and
(C) A description of the signs and symptoms of exposure that the employee is experiencing, if
any.
(4) Physician's written opinion.
(A) For examination or consultation required under this standard, the employer shall obtain a
written opinion from the examining physician which shall include the following;
1. Any recommendation for further medical follow-up;
2. The results of the medical examination and any associated tests, if requested by the employee;
3. Any medical condition which may be revealed in the course of the examination which may
place the employee at increased risk as a result of exposure to a hazardous chemical found in the
workplace; and
4. A statement that the employee has been informed by the physician of the results of the
consultation or medical examination and any medical condition that may require further examination or
treatment.
(B) The written opinion shall not reveal specific findings of diagnoses unrelated to occupational
exposure.
(h) Hazard identification.
(1) With respect to labels and material safety data sheets;
(A) Employers shall ensure that labels on incoming containers of hazardous chemicals are not
removed or defaced.
(B) Employers shall maintain in the workplace any material safety data sheets that are received
with incoming shipments of hazardous chemicals, and ensure that they are readily accessible to
laboratory employees during each work shift when they are in their work area(s).
(2) The following provisions shall apply to chemical substances developed in the laboratory;
(A) If the composition of the chemical substance which is produced exclusively for the
laboratory's use is known, the employer shall determine if it is a hazardous chemical as defined in
subsection 5191(b). If the chemical is determined to be hazardous, the employer shall provide appropriate
training as required under subsection 5191(f).
(B) If the chemical produced is a byproduct whose composition is not known, the employer shall
assume that the substance is hazardous and shall implement subsection 5191(e).
36
§5191.
Title 8, CCR
(C) If the chemical substance is produced for commercial purposes by another user outside of the
laboratory, the employer shall comply with the Hazard Communication Standard (Section 5194)
including the requirements for preparation of material safety data sheets and labeling.
(i) Use of respirators.
Where the use of respirators is necessary to maintain exposure below permissible exposure
limits, the employer shall provide, at no cost to the employee, the proper respiratory equipment.
Respirators shall be selected and used in accordance with the requirements of Section 5144.
(j) Record keeping.
(1) The employer shall establish and maintain for each employee an accurate record of any
measurements taken to monitor employee exposures and any medical consultation and examinations
including tests or written opinions required by this regulation.
(2) The employer shall ensure that such records are kept, transferred, and made available in
accordance with Section 3204.
(k) Dates
(1) Employers shall have developed and implemented a written Chemical Hygiene Plan no later
than October 31, 1991.
(2) Subsection (a) (2) shall not take effect until the employer has developed and implemented a
written Chemical Hygiene Plan.
( l ) Appendices. The information contained in the appendices is not intended, by itself, to create any
additional obligations not otherwise imposed or to detract from any existing obligation.
Note: Authority cited: Sections 142.3 and 9020, Labor Code. Reference: Sections 142.3, 9004(d), 9009
and 9020, Labor Code.
History
1. New section filed 3-25-91; operative 4-24-91 (Register 91, No. 17).
2. Editorial correction of printing errors (Register 92, No. 33).
3. Change without regulatory effect amending Appendix B subsections (b)1. and (c)1. filed 12-28-92
pursuant to section 100, title 1, California Code of Regulations (Register 93, No. 1).
37
APPENDIX B
Laboratory Safety Inspection Checklist
38
LABORATORY SAFETY INSPECTION CHECKLIST
Page 1
This form is consistent with current governmental regulations. However, the regulations are subject to
interpretation by individual inspectors. This form shall be used as a guideline for performing a laboratory
inspection; it is not intended to bring a lab into full compliance.
The design of the form is to identify areas that need improvement with respect to regulatory compliance. “Y”
answers indicate a satisfactory situation, while “N” indicates an area that needs improvement. These areas can
then be prioritized in order of severity. “N/A” indicates a not applicable situation.
Building
#:________
Room #:______
Date:____________
Principal
Investigator:___________________________
Time:_______
Department:__________________________
Survey Conducted By:______________________________________________________________
Y - Satisfactory
Y
N
N - Needs Improvement
N/A - Not Applicable
N/A
HAZARDOUS MATERIALS
1. DOCUMENT AVAILABILITY
a. Chemical inventory is complete, current and readily accessible to employees at a central location.
Location: ______________________________________
b. MSDSs are on file in department and readily accessible to employees.
Location:_______________________________________
c. The CSPL is readily available in the laboratory, and the Standard Operating Procedures for this
specific laboratory are attached.
d. In the case of teaching laboratories, the CSPL and SOPs are filed in the department office.
e. If applicable, a current Prior Approval Form signed by the Department Chairperson is readily
available in the laboratory.
2. LABELING
a. Containers of stock solutions properly identified (e.g. buffers labeled and marked with the words
"buffer").
b. Original product names (or full chemical names) and hazards (health and physical hazards)
clearly identified on labels. This includes those in fume hoods and bio-safety cabinets.
c. Containers of non-hazardous substances (e.g., water) labeled explicitly to avoid confusion.
d. Synthesized, unnamed chemicals labeled by their reactants and possible products (or by a useful
generic description) and with their probable hazards (health and physical hazards).
e. All containers such as vats and storage tanks labeled as to their contents.
3. CONTROL
a. Designated area established for the use of particularly hazard substances, including "select
carcinogens," reproductive toxins and substances which have a high degree of acute toxicity. .
b. Incompatible chemicals segregated by chemical physical class.
c. Infectious waste placed in closed, leak-proof containers, bags or puncture-resistant holders with
proper labels.
d. Containers of peroxide-forming chemicals are dated upon receipt and disposed of within
manufacturer's suggested expiration dates (shelf life).
39
e. Secondary containment provided, as required.
40
LABORATORY SAFETY INSPECTION CHECKLIST
Page 2
N - Needs Improvement
N/A - Not Applicable
Y - Satisfactory
Y
N
N/A
HAZARDOUS MATERIALS (cont’d)
3. CONTROL (cont'd)
f. All chemical containers capped and sealed, except when actively adding or removing materials
from them.
g. No disposal of chemicals by evaporation into a fume hood.
4. STORAGE OF FLAMMABLE /COMBUSTIBLE LIQUIDS
a. Liquids not dispensed from gravity-fed or bottom-dispensing containers (use lid-mounted
pumps).
b. Approved containers and tanks used for the storage and handling of flammable and combustible
liquids.
c. Flammable liquid storage cabinet(s) used and adequate for needs
d. Flammable liquids in quantities in excess of 10 gallons are stored in a flammable liquid storage
cabinet with self-closing door.
e. All flammable liquid cabinets are free of combustible materials (cardboard, paper, etc.)
f. Approved metal safety cans are limited to 5 gallons maximum.
g. Flammable liquids in excess of one day's operational supply kept in approved flammable
cabinets.
h. Storage areas for hazardous substances are properly segregated to ensure that incompatible
chemicals are not kept together (e.g., corrosives not stored with flammables).
i. Bulk drums of flammable liquids grounded and bonded to containers during dispensing.
j. All flammable liquids kept in closed containers when not in use (e.g. parts cleaning tanks, pans).
k. Storage rooms for flammable and combustible liquids have explosion-proof lights.
l. Storage rooms for flammable and combustible liquids have mechanical or gravity ventilation.
m. Fire separators placed between containers of combustibles or flammables, when stacked one
upon another, to assure their support and stability.
n. Ether and other highly-flammable liquids are stored away from sources of heat and ignition.
HAZARDOUS WASTE
1. CONTAINMENT AND STORAGE
a. Waste is contained according to the campus hazardous waste management Policy and Procedures
Manual.
b. Specific storage containers provided for (check applicable categories):
chemical wastes ( ); recyclable solvents ( ); radioactive waste ( ); bio-hazardous wastes ( ); sharps
( ); mixed wastes ( ).
c. Waste containers are sturdy, routinely inspected for leaks, compatible with the waste, and kept
closed when hazardous waste is not being added or removed.
d. Incompatible wastes are not stored together.
e. Not stored for more than 90 days from the initial date of accumulation.
f.. Records kept of waste pick-up requests, including date contacted and date picked up.
2. CHEMICAL WASTE LABELING
a. Containers are labeled with the initial date of accumulation, with the words "Hazardous Waste,"
with the waste's physical state and hazard class (e.g. flammable), with full product names, with
appropriate percentages, and with the EH&S tracking number.
b. EH&S waste tracking forms are available and used on all hazardous waste containers.
c. Synthesized, unnamed chemical wastes labeled by their reactants and possible products (or by a
useful generic description) and with their probable hazards (physical and health hazards).
41
LABORATORY SAFETY INSPECTION CHECKLIST
Page 3
Y - Satisfactory
Y
N
N - Needs Improvement
N/A - Not Applicable
N/A
HAZARDOUS WASTE (cont’d)
3. BIOHAZARDOUS WASTES
a. Contained in red bags that are labeled as bio-hazardous waste.
b. Syringes/needles and other sharps disposed of in sharps containers and emptied regularly
(weekly).
c. All infectious waste bags are red in color.
d. Animal carcasses and/or infectious tissues are properly contained and disposed of.
HEALTH AND SAFETY TRAINING
1. TRAINING OCCURS:
a. When an employee or student first begins work.
b. When an employee or student is given a new assignment for which training has not previously
been received.
c. Whenever new hazards are introduced into the workplace by new substances, processes or
equipment.
d. Whenever the supervisor is made aware of a new or previously unrecognized hazard.
2.
a.
b.
c.
d.
e.
EMPLOYEES TRAINED ON:
The University's Hazard Communication Program.
The University's Chemical Safety Plan for Laboratories.
The applicable laboratory-specific Standard Operating Procedures.
Any supplemental procedures listed on a Prior Approval Form for this laboratory.
Information concerning safety administration, programs, and procedures applicable to the
college, department or building.
f. Employees are periodically instructed in the use of fire extinguishers.
RECORD KEEPING
a. Records of employee and student participation in safety and health training are maintained (retain
records for duration of employment).
b. Documentation is complete for safety training classes and other training situations (e.g. one-onone).
c. Documentation of safety inspections and corrections maintained.
d. Carcinogen use reports filed with Cal/OSHA as required.
e. Chemical Safety Committee meeting records maintained.
f. A file of departmental Standard Operating Procedures is maintained by the DSC.
g. A central departmental file is maintained for Prior Approval Forms signed by Chairperson.
42
LABORATORY SAFETY INSPECTION CHECKLIST
Page 4
Y - Satisfactory
Y
N
N - Needs Improvement
N/A - Not Applicable
N/A
HEALTH AND SAFETY EQUIPMENT
1. SAFETY SHOWERS AND EYE WASHES
a. Approved safety showers and eye washes provided within the work area for immediate use
(within 10-15 seconds of exposure) and with access to them unobstructed.
b. Safety showers and eye washes are unobstructed.
c. Safety showers and eye washes are inspected and maintained regularly to ensure proper
operation.
2.
a.
b.
c.
d.
LABORATORY FUME HOODS
Certified (air flow check) within the last year.
Air flow indicator present and operating properly.
Storage within the hood minimized and containers kept sealed.
Front sash is lowered to appropriate level when hood is in use (sticker is in place to indicate sash
height).
3. BIOLOGICAL SAFETY CABINETS (e.g., Laminar flow hoods)
a. Tested and certified within last year.
b. Proper type of work being conducted in cabinet.
4. COMPRESSED GAS CYLINDER SAFETY
a. Cylinders protected from external heat sources and stored in well-protected, well-vented, dry
locations away from highly combustible materials.
b. Storage space will not be damaged by passing or falling objects and not subject to tampering by
unauthorized persons.
c. Secured to a structural component of the building with chains at 2/3 and l/3 of the cylinder
height.
d. Protective caps in place while the cylinders are not in use or connected for use.
e. Only chemically compatible cylinders stored together.
f. Cylinder contents adequately identified on a label that can easily be seen.
5. HOUSEKEEPING AND MISCELLANEOUS LABORATORY SAFETY
a. Damaged or malfunctioning equipment is tagged out of service.
b. All work areas (bench tops, office/desk areas) are kept clean and organized and environment
maintained to eliminate harmful exposures or unsafe conditions.
c. Vacuum lines are equipped with traps designed specifically to accumulate/filter the hazardous
materials being evacuated.
d. All vacuum pump belts adequately protected by a rigid belt guard or housing.
e. Extension cords not used as permanent wiring and no equipment has frayed electrical cords.
f. High voltage equipment (greater than 600 V) labeled, grounded, and insulated.
43
LABORATORY SAFETY INSPECTION CHECKLIST
Page 5
Y - Satisfactory
Y
N
N - Needs Improvement
N/A - Not Applicable
N/A
HEALTH AND SAFETY EQUIPMENT (cont’d)
6. PERSONAL PROTECTIVE EQUIPMENT (PPE) USED AND REQUIRED IN LAB
(Check applicable categories)
( ) Safety glasses/goggles/face shields ( ) Lab coats/aprons
( ) Respiratory protection
( ) No open-toe footwear
a.
b.
c.
d.
( ) Gloves
( ) PPE for radiological work
When not in use, is personal protective equipment properly maintained/stored?
Are areas requiring use of protective equipment adequately posted and enforced?
Respiratory protection use conforms to the university "Respiratory Protection Program".
Respirators are stored in a way that avoids exposure to excessive heat, dust and chemicals.
EMERGENCY PREPAREDNESS
1.
a.
b.
c.
d.
e.
BASIC EARTHQUAKE SAFETY
Shelves have lips or other seismic restraints.
Cabinets and bookshelves are secured to walls.
Computers secured to desks, bench tops.
Overhead storage is minimized and restrained from falling.
Emergency action and fire prevention plans available.
2. CONTINGENCY PLANNING AND EMERGENCY PROCEDURES
a. Chemical spill kit/cleanup materials provided.
b. Training in spill clean-up procedures provided and documented.
3.
a.
b.
c.
FIRST AID MATERIALS
kept in adequate supply.
kept in sanitary and usable condition.
are made readily available.
4. FIRE PREVENTION AND ELECTRICAL SAFETY
a. Appropriate fire extinguisher available (unobstructed) within 75 feet and inspected within the last
year.
b. Fire extinguishers mounted and clearly visible.
c. 18 inch vertical clearance maintained from sprinkler heads (e.g., over shelves or equipment).
5.
a.
b.
c.
EXITS AND WIDTH OF EXITS
Exits and aisles are clear and free of potential obstructions in case of emergency.
Exit signs are posted to clearly indicate exits.
Width of exit aisles and pathways not less than 28 inches.
44
LABORATORY SAFETY INSPECTION CHECKLIST
Page 6
Y - Satisfactory
Y
N
N - Needs Improvement
N/A - Not Applicable
N/A
EMERGENCY PREPAREDNESS (cont’d)
6.
a.
b.
c.
d.
ELECTRICAL
At least 30 inches of clearance in front of electrical panels/breaker boxes.
Electric hand tools are properly grounded/double insulated.
Electric cords are insulated and free from damage/fraying.
Circuit breaker panels are free of combustible materials.
EMPLOYEE EXPOSURE
a. Employee exposure to chemicals is monitored and kept within acceptable levels (below regulated
limits).
45
APPENDIX C
Hazard Communication Program Summary
46
HAZARD COMMUNICATION PROGRAM SUMMARY
The information below provides a summary of the provisions under the Hazard Communication Program
(HCP). For specific details concerning the HCP refer to the Cal Poly Hazard Communication Program
Manual.
Departments shall ensure that each employee receives information and training on hazardous substances in
his/her work area at the time of initial assignment, whenever a new potential hazard is introduced into the
work area, or when an employee is given a new job or task assignment for which no previous training has
been provided. The Environmental Health and Safety Department will provide general Hazard
Communication Training.
Departments shall furnish employees with general information about the purpose of an MSDS as well as
specific information concerning the contents of the MSDS for any hazardous substance to which the
employees are exposed.
When training employees who may be exposed to hazardous substances, the department shall ensure that
each of the following hazard communication training requirements are covered:
a.
b.
c.
d.
Each department shall ensure the following information is explained as outlined in the
MSDS:
1.
Any health hazards associated with the use of this substance or mixture;
2.
Proper precautions for handling, necessary personal protective equipment, and
other safety precautions necessary to minimize or prevent exposure to the
hazardous substance;
3.
Emergency procedures for fire, spills, disposal, and first aid. The information may
relate to an entire class of hazardous substances to the extent appropriate and
related to the job.
4.
Significant revisions in the MSDS shall be provided to all employees.
Each department shall inform employees of their right:
1.
To personally receive information regarding hazardous substances to which they
may be exposed;
2.
For their physician or collective bargaining agent to receive such information;
3.
To be protected from dismissal or other discrimination due to the employee's
exercise of their rights afforded by this law.
Departments shall ensure employees are informed of:
1.
Requirements of the HCP;
2.
Any operations in their work area where hazardous substances are present;
3.
Location and availability of the written HCP.
Departments shall ensure that employees are trained in:
1.
Methods and observations that may be used to detect the presence or release of
hazardous substances in the work area.
2.
Physical and health hazards of the substances in the work area and the measures
they can take to protect themselves from these hazard; These measures shall
include specific procedures the department has implemented to protect employees
from exposure to hazardous substances.
3.
Details of the HCP including an explanation of the labeling system, the MSDS, and
how employees can obtain and use the appropriate hazard information.
47
APPENDIX D
Training Documentation Form
48
TRAINING DOCUMENTATION FORM
Name of Trainer:_________________________________ Dept._____________ Date:___________
Subjects Covered:_________________________________________________________________
_______________________________________________________________________________
_______________________________________________________________________________
Type of Training: ______________________ Initial____ Refresher____ Total Time: ______hours
Handouts Provided:________________________________________________________________
ATTENDEES
Print Name
Signature
Distribution of Copies: Department Office, DSC, EH&S, Training Provider
49
APPENDIX E
Chemical Donation Procedure
50
CHEMICAL DONATION PROCEDURE
Due to regulatory requirements and escalating disposal costs, this procedure for chemical
donations applies to all Departments which accept chemical donations regulated by Federal,
State, and local agencies. The Environmental Health and Safety Department will assist in the
donation process by providing information on legal requirements and estimates of potential costs
associated with proposed donations.
The following are the procedures to be followed:
1.
Donations of hazardous chemicals must receive clearance in advance by the Dean or
Director, Manager, and the Environmental Health and Safety Department (see attached
form).
2.
All chemicals accepted must be in sealed, unopened, undamaged, and properly labeled
original containers (manufacturer’s label is usually the best certification that the contents
are accurately identified).
3.
Material Safety Data Sheets (MSDSs) must be obtained for all donated materials before
the materials are brought onto campus. The MSDS must be provided to the
Environmental Health and Safety Department as part of the approval process.
4.
Delivery of the donations must adhere to all DOT regulations relating to the
transportation of hazardous materials (which include chemical materials). If the donation
quantities are large amounts (5 gal. or more) or if they are “extremely hazardous,”
radioactive, or FDA regulated substances, special transportation, packaging, or labeling
may be required. The EH&S Department must be contacted prior to pickup/delivery of
any donated chemicals, without exception.
5.
Complete inventories of all materials received shall be provided to the EH&S Department
to insure campus inventory update requirements in accordance with Business Plan
regulations (Chapter 6.95, California Health and Safety Code). Inventories must be
provided as part of the approval process in advance of taking possession of the donated
materials.
6.
Certain donated chemicals and regulated materials may be subject to special disposal
requirements or limitations which may result in costly disposal fees.
7.
The following Chemical Donation Form and abbreviations must be used when accepting or
donating chemicals.
51
APPENDIX F
Chemical Donation Form
52
CHEMICAL DONATION FORM
Abbreviations
The abbreviations presented below must be used on the Chemical Donation Form. All mixtures must
identify the chemical compounds in the mixture and the corresponding concentrations. Examples are
provided on the first few lines on the attached Form.
Unit Values
L - liters
ml - milliliters
gal - gallons
cf - cubic feet
g - grams
oz - ounces
kg - kilograms
lb - pounds
Container Type
C - Can
CY - Cylinder
DM - Metal Drum
DF - Fiber/Plastic Drum
CM - Metal Box/Container
CF - Fiber/Plastic Box /Container
CW - Wood Box/Container
BA - Bag
BG - Bottle Glass
BF - Bottle Fiber/Plastic
53
Physical
State
G - Gas
L - Liquid
S - Solid
DOT Classification
(Hazard Class- list all that apply)
Class-1 Explosives
Class-2 Compressed Gasses
Class-3 Flammable liquids
Class-4 Flammable Solids
Class-5 Oxidizers
Class-6 Poisons
Class-7 Radioactive Material
Class-8 Corrosive Material
Class-9 Misc. Dangerous Material
CHEMICAL DONATION FORM
Name:________________________________
Date:_____________
Time:_____________
Location
003-201
Chemical Name
Hydrofluoric Acid
044-002
003-132
Nitrox
Borax (Soap)
Department:____________________________
Building:__________
Room:____________
Aisle:_____________
Shelf:_____________
Concentration
Mixture (%)
97
Oxygen 35
Nitrogen 65
25
Container
Type
BG
Container
Quantity
2
Units Per
Container
2.5 L
Total Units
3L
Ph
CY
CF
2
3
80 cf
1.5 lb.
160 cf
3.5 lb.
* Location - Building and Room Number
Proposed Method of
Shipment/Delivery:___________________________________________________________________________________
__________________________________________________________________________________________________
_____________________________________________________________________________________________
 Reviewed by DSC
Department Safety Coordinator:_____________________________________________________
 Approve
 Disapprove
Department Chair/Manager:__________________________________________________
 Approve
 Disapprove
Dean/Director:____________________________________________________________
 Approve
 Disapprove
EH&S Office:_____________________________________________________________
Comments:_________________________________________________________________________________________
__________________________________________________________________________________________________
_____________________________________________________________________________________________
54
APPENDIX G
Standard Operating Procedures & Prior Approval Form
55
Standard Operating Procedures & Prior Approval Form
(page 1 of 3)
INSTRUCTIONS: COMPLETE THIS PAGE AND PART I AND/OR PART II, AS APPLICABLE
Indicate with a check () which of the following apply:
[ ] SOP Submission Only- prior approval from Department Chair is not required for this experiment.
[ ] Both SOP Submission and Application for Prior Approval- complete both Parts I & II of this form.
[ ] Prior Approval Only- SOP is already on file (complete Part II and attach a copy of the SOP).
Prepared by: ______________________________________ Dept.______________ Date: _________
Check () One: [ ] Principal Investigator;
[ ] Course Instructor;
[ ] Lead Technician
Name of the Specific Experiment or Process: _____________________________________________
For instructional laboratory: Title of Course ____________________________________________
For research laboratory: Name of Research Project _______________________________________
Laboratory Location: Bldg. ____________;
Room _______
If applicable: Location in Room: ______________________________________________________
(in situations where the same room is divided into several research areas)
If applicable: Day of week _________________ ; time of day ___________
(in situations where the same work area is utilized by another instructor or investigator at another time)
Distribution:
a. If submitting only a Standard Operating Procedures Form:
Send original to DSC with copy to Department Office; keep a copy in the room where the
experiment or process will take place.
b. If this submission contains an Application for Prior Approval:
Submit all paperwork to Dept. Chair (or, depending on department policy, to the DSC for
preliminary review); after approval, keep a copy with the Chair's signature in the laboratory.
Training and Documentation:
Principal investigators, course instructors and lead technicians must ensure that SOPs and any additional
precautions listed on an Application for Prior Approval have been explained to and understood by the
workers/students under their control. Maintain written documentation showing that this training has
taken place.
Department Tracking Information: ____________________________________
EH&S Tracking Information: _______________________________________
56
PART I:
STANDARD OPERATING PROCEDURES
(SOP&PA page 2 of 3)
List the hazardous chemical(s) which will be used and the class* of each chemical. Include information
about hazardous byproducts: ___________________________________________________________
____________________________________________________________________________________
____________________________________________________________________________________
Describe the process: __________________________________________________________________
____________________________________________________________________________________
____________________________________________________________________________________
____________________________________________________________________________________
Describe the methods laboratory workers shall use to minimize the health and safety risks associated
with the hazardous chemicals. (circle all that apply and add details as necessary)
a. personal protective equipment: goggles - face shield - gloves - protective apparel - shoes - respirator
b. engineering controls: fume hood - snorkel - glove box
____________________________________________________________________________________
____________________________________________________________________________________
Indicate any special chemical storage procedures:____________________________________________
____________________________________________________________________________________
List equipment which will be available in case of a spill or accident(circle all that apply and add details
as necessary): Eyewash - shower - fire extinguisher - spill control materials - first aid kit
____________________________________________________________________________________
Describe emergency procedures for spills or accidents: _______________________________________
____________________________________________________________________________________
____________________________________________________________________________________
Discuss steps you will take to minimize the amount of waste created: ____________________________
____________________________________________________________________________________
____________________________________________________________________________________
Discuss waste disposal: ________________________________________________________________
____________________________________________________________________________________
Is prior approval to be obtained by laboratory workers who are assisting on the project? YES - NO
If "YES," please provide details in the following questions:
a. Indicate whether prior approval is required for the experiment as a whole: YES - NO
b. Indicate whether prior approval is required for certain aspects of the experiment or in certain
circumstances: YES - NO If yes, give details ___________________________________________
c. If answer to either (a) or (b) is "yes," who is authorized to give prior approval (check one)?
[ ] person listed in at top of page one; or [ ] another person (specify) __________________________
* SUGGESTED ABBREVIATIONS OF HAZARD CLASSES: Explosion- E; Compressed Gas- CG; Flammable- F;
Oxidizer- Ox; Toxic- T; Infectious- I; Radioactive- RA; Corrosive- C
57
PART II:
PRIOR APPROVAL FROM DEPARTMENT CHAIR
(SOP&PA page 3 of 3)
(submit this section only when there are special circumstances which require prior approval)
REASON PRIOR APPROVAL IS REQUIRED (check () all that apply):
[ ] A. Work will take place outside normal operating hours.
[ ] B. Experiments will involve one person working alone. (Note: such permission is seldom granted.)
[ ] C. Experiments will be running at times when nobody is present in the laboratory.
[ ] D. Experiment involves the use of a particularly hazardous substance.
If you have checked A, B, or C:
Describe special precautions which will be taken:
____________________________________________
____________________________________________________________________________________
____________________________________________________________________________________
____________________________________________________________________________________
____________________________________________________________________________________
If you have checked box D (Particularly Hazardous Substances), discuss all of the following:
a. Describe the establishment of a designated area: ___________________________________________
____________________________________________________________________________________
____________________________________________________________________________________
____________________________________________________________________________________
b. Describe special decontamination procedures: ____________________________________________
___________________________________________________________________________________
___________________________________________________________________________________
c. Describe procedure to handle particularly hazardous waste: __________________________________
___________________________________________________________________________________
___________________________________________________________________________________
SIGNATURE OF APPLICANT __________________________________ Date ____________
---------------------------------------------------------------------Preliminary Review by Dept. Safety Coordinator (optional, depending on department policy):
Comments:___________________________________________________________________
Signature of DSC _____________________________________ Date ___________
Action by Dept. Chair: Approve [ ]
Deny [ ]
Comments:_____________________________
__________________________________________________________________________________
Signature of Dept. Chair ______________________________________ Date ___________
Approval expires on:_____________________ (approvals granted for maximum of three
months)
58
Distribution: Dept. Chair will sign and send copies to the DSC, EH&S, and applicant.
59
APPENDIX H
Permissible Exposure Limits for Chemical Contaminants
California Code of Regulations, Title 8, Section 5155, Table AC-1
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
Ceiling(g)
75070
Acetaldehyde
25
45
C
64197
Acetic acid
10
25
40 ppm
108247
Acetic Anhydride
5
20
C
67641
Acetone
500
1200
75868
Acetone cyanohydrin as CN
4.7
5
Acetonitrile
40
70
Acetophenone
10
49
1
14
0.1
0.25
75058
S
98862
53963
S
74862
540590
2-Acetylaminofluorene; N-fluoren-2-yl
acetamide; see Section 5209
Acetylene
79345
50782
107028
S
Acrolein
79061
S
Acrylamide
79107
S
Acrylic acid
107131
S
Acrylonitrile; see Section 5213
124049
S
Adiponitrile
309002
S
107186
S
Aldrin; 1,2,3,4,10,10-hexachloro1,4,4a,5,8,8a-hexahydro-endo-1,2-exo-5,8dimethanonaphthalene
Allyl alcohol
15
37
750
1780
60
105
10
C
5
--
Adipic acid
111693
STEL (o)
mg/M3(f)
(h)
Acetylene dichloride; see 1,2Dichloroethylene
Acetylene tetrabromide:1,1,2,2tetrabromoethane
Acetylene tetrachloride; see 1,1,2,2Tetrachloroethane
Acetylsalicylic acid (Aspirin)
79276
3000 ppm
STEL (o)
ppm(e)
C
0.03
2
5.9
2
4.5
2
8.8
--
5
--
0.25
0.5
1.25
4
Allyl chloride
1
3
2
6
Allyl glycidyl ether; AGE
5
22
10
44
2179591
Allyl propyl disulfide
2
12
3
18
1344281
Alumina; see Particulates not otherwise
regulated
Aluminum, alkyls (not otherwise classified)
--
2
Aluminum soluble salts
--
2
Aluminum metal and oxide Total dust
--
Aluminum metal and oxide Respirable
fraction(n)
Aluminum pyro powders
---
5
Aluminum welding fumes
--
5
107051
106923
S
60
10
5(n)
Name(c)
PEL (d)
ppm(e)
300925
Aluminum distearate
--
10
7047849
Aluminum stearate
--
10
637127
Aluminum tristearate
--
10
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
1300738
92671
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
35
27
4-Aminodiphenyl; see Section 5209
2-Aminoethanol; see Ethanolamine
91598
504290
2-Aminonapthalene; see betaNaphthylamine, Section 5209
2-Aminopyridine
61825
Amitrole
7664417
Ammonia
S
0.5
--
2
0.2
25
18
Ammonium perfluorooctanoate
--
0.1
12125029
Ammonium chloride fume
--
10
1002897
Ammonium stearate
--
10
7773060
Ammonium sulfamate Total dust
--
10
7773060
Ammonium sulfamate Respirable fraction(n)
--
5
620111
3-Amyl acetate; See Pentyl acetate
628637
n-Amyl acetate; See Pentyl acetate
626380
sec-Amyl acetate (all isomers and mixtures);
See Pentyl acetate
tert-Amyl acetate; See Pentyl acetate
625161
62533
S
Aniline
29191524
S
Anisidine (ortho and para isomers)
86884
7440371
7440382
2
7.6
0.1
0.5
Antimony and compounds, as Sb
--
0.5
ANTU; 1-(1-naphthyl)-2-thiourea; Bantu;
Rattrack
Argon
--
0.3
Arsenic and inorganic arsenic compounds;
see also Section 5214
Arsenic, organic compounds, as As
--
0.2
Arsine; AsH3
Asbestos (including actinolite, amosite
anthophyllite, chrysotile, crocidolite, and
tremolite); see Section 5208
Asphalt (petroleum) fumes
0.1 f/cc
Atrazine
--
5
Azinphos methyl; o,o-dimethyl S-(4-oxo1,2,3-benzotriazin-3(4H)-ylmethyl)
phosphorodithioate
2,2'-Azobisisobutyronitrile decomposition
product, see Tetramethyl succinonitrile
Barium, soluble compounds, as Ba
--
0.2
1912249
86500
S
3333526
S
7440393
0.05
--
0.2
5
--
0.5
17804352
Barium sulfate; see Particulates not
otherwise regulated
Benomyl Total dust
--
10
17804352
Benomyl Respirable fraction(n)
--
5
7727437
S
20
0.01
1332-21-4
8052424
--
(h)
7784421
71432
Ceiling(g)
Aminodimethylbenzene; see Xylidene
S
141435
3825261
PEL (d)
mg/M3(f)
Benzene; see also Section 5218
1
61
5
--
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
92875
S
71432
Benzidine; 4,4'-diaminobiphenyl, see Section
5209
Benzol; see Benzene
106514
D-Benzoquinone; see Quinone
98884
Benzoyl chloride
94360
Benzoyl peroxide; dibenzoyl peroxide
140114
Benzyl acetate
100447
benzyl chloride; alpha-chlorotoluene
7440417
Beryllium, and beryllium compounds as Be
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
0.2
1.1
10
61
1
5
--
Ceiling(g)
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
C
5
--
0.0002
0.025mg/M
--
3
92524
Biphenyl; diphenyl; phenylbenzene
542881
Bis(chloromethyl) ether, see bisChloromethyl ether, Section 5209
Bis (Dimethylaminoethyl) ether (DMAEE)
3033623
S
0.2
1.5
0.05
0.328
1304821
Bismuth telluride Total dust
--
10
1304821
Bismuth telluride Respirable fraction(n)
--
5
Bismuth telluride (selenium-doped)
--
5
Borates, tetra, sodium salts Anhydrous
--
5
Borates, tetra, sodium salts Decahydrate
--
5
Borates, tetra, sodium salts Pentahydrate
--
5
1303862
Boron oxide
--
10
10294334
Boron tribromide
1
7637072
Boron trifluoride
314409
Bromacil
7726956
7789302
74975
Bromochloromethane; see
Chlorobromethane
Bromoethane; see Ethyl bromide
74964
75252
S
10
C
1
3
C
1
10
Bromine
0.1
0.7
Bromine pentafluoride
0.1
0.7
0.5
5
Bromoform; tribromomethane
74839
Bromomethane, see Methyl bromide
75638
106990
Bromotrifluoromethane; see
Trifluorobromomethane
1,3-Butadiene (see also section 5201)
106978
Butane
109795
1-Butanethiol; see Butyl mercaptan
71363
1-Butanol; see n-Butyl alcohol
78933
2-Butanone; see Methyl ethyl ketone
111762
20
97
n-Butyl acetate
150
710
105464
sec-Butyl acetate
200
950
540885
tert-Butyl acetate
200
950
141322
Butyl acrylate
2
11
S
2-Butoxyethanol (EGBE)
2.2
1,900
123864
71363
S
1
800
50
150
78922
n-Butyl alcohol; 1-butanol
sec-Butyl alcohol
100
305
75650
tert-Butyl alcohol
100
300
62
0.15
0.983
5
11
200
950
150
450
C
C
109739
S
Butylamine
1189851
S
tert-Butyl chromate; di-tert-butyl chromate,
as CrO3 (see also Sections 1532.2, 5206 &
8359)
5
--
63
15
C
0.1
C
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
1189851
S
1189851
S
tert-Butyl chromate; di-tert-butyl as Cr (see
also Sections 1532.2, 5206 & 8359)
tert-Butyl chromate; di-tert-butyl
2426086
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
25
138227
5
25
109795
n-Butyl mercaptan
0.5
1.5
o-sec-Butylphenol
5
30
S
p-tert-Butyltoluene
7440439
--
0.005
--
0.005
--
0.005
156627
Cadmium metal dust, as Cd (see also
Sections 1532 & 5207)
Cadmium, soluble salts, as Cd (see also
Sections 1532 & 5207)
Cadmium oxide fume, as Cd (see also
Sections 1532 & 5207 )
Calcium arsenate; see Arsenic,inorganic
(see also Section 5214)
Calcium carbonate; see Particulates not
otherwise regulated
Calcium cyanamide
--
0.5
1305620
Calcium hydroxide
--
5
1305788
Calcium oxide
--
2
1344952
Calcium silicate; see Particulates not
otherwise regulated
Calcium silicate (synthetic): see Particulates
not otherwise regulated
Calcium stearate
--
10
76222
Calcium sulfate; see Particulates not
otherwise regulated
Camphor (synthetic)
--
2
105602
Caprolactam dust
--
1
7778441
471341
1592230
7778189
105602
2425061
1
5
--
0.1
133062
Captan
--
5
63252
Carbaryl; 1-naphthyl N-methylcarbamate
--
5
1563662
Carbofuran
--
0.1
1333864
Carbon black
--
3.5
75150
Carbon dioxide
S
Carbon disulfide
5,000
9,000
4
12
30 ppm
200 ppm
630080
Carbon monoxide
25
29
558134
Carbon tetrabromide
0.1
1.4
Carbon tetrachloride
2
12.6
56235
S
75445
9004346
21351791
200 ppm
3
10
40
30,000
54,000
12
36
0.3
4
10
63
5
15
Carbonyl chloride; see Phosgene
353504
120809
120
--
20
Captafol
124389
20
6.1
--
Caprolactam vapor
S
STEL (o)
mg/M3(f)
135
98511
1306190
STEL (o)
ppm(e)
0.005
n-Butyl glycidyl ether; BGE; 1-butoxy-2,3epoxypropane
n-Butyl lactate
89725
Ceiling(g)
S
Carbonyl fluoride
2
5
Catechol; pyrocatechol
5
20
Cellulose (paper fiber); see Particulates not
otherwise regulated
Cesium hydroxide
2
64
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
PEL (d)
ppm(e)
57749
S
--
0.5
8001352
S
Chlordane; 1,2,4,5,6,7,8,8-octachloro3a,4,7,7a-tetrahydro-4,7-methanoindane
Chlorinated camphene; toxaphene
--
0.5
Chlorinated diphenyl oxide
--
PEL (d)
mg/M3(f)
Ceiling(g)
--
Chlorine
0.5
1.5
10049044
Chlorine dioxide
0.1
0.3
7790912
Chlorine trifluoride
0.1
0.4
C
107200
Chloroacetaldehyde
1
3
C
C
S
Chloroacetone
1
3.8
0.05
0.3
S
alpha-Chloroacetophenone;phenacyl
chloride
Chloroacetyl chloride
0.05
0.2
Chlorobenzene; monochlorobenzene
10
46
532274
79049
108907
2698411
S
74975
126998
S
75456
o-Chlorobenzylidene malononitrile; OCBM
0.05
0.4
Chlorobromomethane; bromochloromethane
200
1,050
1,000
3,500
Chlorodifluoromethane; Fluorocarbon 22
S
Chlorodiphenyl (42% chlorine)
--
1
11097691
S
Chlorodiphenyl (54% chlorine)
--
0.5
75003
1-Chloro-2,3-epoxypropane; see
Epichlorohydrin
Chloroethane; see Ethyl chloride
107073
2-Chloroethanol; see Ethylene chlorohydrin
75014
67663
Chloroethylene, see Vinyl chloride, Section
5210
Chloroform; trichloromethane
74873
Chloromethane, see Methyl chloride
107302
600259
Chloromethyl methyl ether; see Methyl
chloromethyl ether, Section 5209
bis-Chloromethyl ether, see also Section
5209
1-Chloro-4-nitrobenzene; see pNitrochlorobenzene
1-Chloro-1-nitropropane
76153
Chloropentafluoroethane
542881
100005
76062
2
9.78
0.001
0.005
2
10
1,000
6,320
Chloropicrin; trichloronitromethane
0.1
0.7
126998
S
Chloroprene; 2-chloro-1,3-butadiene
10
36
598787
S
2-Chloropropionic acid
0.1
0.44
o-Chlorostyrene
50
285
S
o-Chlorotoluene
50
250
S
2-Chloro-6-(trichloromethyl)pyridine; see
Nitrapyrin
Chlorpyrifos
2039874
95498
1929824
2921882
7440473
1
1
3
0.3
0.9
0.15
0.69
75
428
C
2-Chloro-1,3-butadiene; see Chloroprene
53469219
106898
STEL (o)
mg/M3(f)
0.5
7782505
78955
STEL (o)
ppm(e)
--
0.2
Chromite ore processing (chromate), as Cr
(see also Sections 1532.2, 5206 & 8359)
Chromium metal
--
0.005
--
0.5
Chromium (II) compounds, as Cr
--
0.5
65
Name(c)
PEL (d)
ppm(e)
Chromium (III) compounds, as Cr
--
0.5
--
0.005
14977618
Chromium (VI) compounds, as Cr (see also
Sections 1532.2, 5206 & 8359)
Chromyl chloride
2971906
Clopidol Total dust
--
10
Clopidol Respirable fraction
--
5
Coal (Bituminous) dust <5% quartz,
respirable fraction(n)
Coal (Bituminous) dust >5% quartz,
respirable fraction(n)
Coal tar pitch volatiles(i)
--
2
--
0.1
--
0.2
Cobalt, metal fume and dust, as Co
--
0.02
Cobalt carbonyl, as Co
--
0.1
Cobalt hydrocarbonyl, as Co
--
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
7440484
16842038
PEL (d)
mg/M3(f)
0.025
0.1
Copper salts, dusts and mists, as Cu
--
1
Corundum, see Particulates not otherwise
regulated
Cotton dust, see also Section 5190
--
Cresol (all isomers)
123739,
4170303
299865
S
Crotonaldehyde; beta-methylacrolein
98828
S
S
0.3
--
Cumene; isopropylbenzene
5
50
245
Cyanamide
--
2
Cyanide, as CN
--
5
Cyanogen
10
20
506774
Cyanogen chloride
0.3
0.6
Cyclohexane
300
1,050
108930
S
Cyclohexanol
50
200
108941
S
Cyclohexanone
25
100
300
1,015
110838
Cyclohexene
108918
S
Cyclohexylamine
121824
S
542927
Cyclonite; RDX;
cyclotrimethylenetrinitramine
Cyclopentadiene
287923
Cyclopentane
13121705
Cyhexatin; tricyclohexyltin hydroxide
94757
2,4-D;2,4-dichlorophenoxyacetic acid
--
10
S
DDT; 1,1,1-trichloro-2,2-bis-(pchlorophenyl)ethane
DDVP, see Dichlorvos
--
1
17702419
S
Decaborane
0.05
0.3
8065483
S
Demeton; a mixture of o,o-diethyl o2(ethylthio)ethyl phosphorothloate and o,o'diethyl S-2(ethylthio)ethyl phosphorothioate
Diacetone alcohol; 4-hydroxy-4-methyl-2pentanone
0.01
0.1
50
240
50293
62737
123422
0.9
22
460195
110827
0.15
1(j)
5
Crufomate
420042
0.1mg/M3
0.1
--
S
STEL (o)
mg/M3(f)
0.15
Copper metal fume, as Cu
1319773
STEL (o)
ppm(e)
0.15
Coke oven emissions, see Section 5211
7440508
Ceiling(g)
10
--
C
40
1.5
75
200
600
1,720
5
66
107153
1,2-Diaminoethane; see Ethylenediamine
Diatomacous earth; see Silica-amorphous
333415
S
Diazinon; o,o-diethyl o-(2-isopropyl-6-methyl4-pyrimidinyl) phosphorothioate
--
67
0.1
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
334883
Diazomethane
94360
Dibenzoyl peroxide; see Benzoyl peroxide
19287457
Diborane
2528361
S
96128
75616
106934
S
102818
S
84742
Dibutyl phthalate
S
106467
91941
S
764410
S
0.1
0.3
3.5
0.001
0.01
2
14
1
5
--
0.4
C
25
150
50 ppm
p-Dichlorobenzene; 1,4-dichlorobenzene
10
60
200 ppm
3,3'-Dichlorobenzidine; 4,4'-diamino-3,3'dichlorobiphenyl; see Section 5209
1,4 -Dichloro-2-butene
0.005
0.025
1000
4950
1,3-Dichloro-5,5-dimethyl hydantoin
75343
1,1-Dichloroethane
107062
1,2-Dichloroethane, see Ethylene dichloride
75354
1,1-Dichloroethylene; see Vinylidene
chloride
1,2-Dichloroethylene; acetylene dichloride
--
Dichloroethyl ether; bis(2-chloroethyl) ether
0.2
100
400
200
790
5
30
10
42
75434
Dichlorofluoromethane; Fluorocarbon 21
75092
Dichloromethane; see Methylene chloride
594729
1,1-Dichloro-1-nitroethane
2
10
78875
1,2-Dichloropropane; see Propylene
dichloride
Dichloropropene
1
5
75990
2,2-Dichloropropionic acid
1
6
76142
1,2-Dichlorotetrafluoroethane; Fluorocarbon
114
Dichlorvos (DDVP); 2,2-dichlorovinyl
dimethyl phosphate
Dicrotophos
1,000
7,000
0.1
1
542756
S
62737
S
141662
S
5124301
--
0.25
77736
Dicyclohexylmethane-4,4'-diisocyanate; see
Methylene bis-(4-cyclohexylisocyanate)
Dicyclopentadiene
102545
Dicyclopentadienyl iron Total dust
--
10
102545
Dicyclopentadienyl iron Respirable
fraction(n)
Dieldrin; 1,2,3,4,10,10-hexachloro-6,7epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endoexo-5,8-dimethanonaphthalene
Diethanolamine
--
5
--
0.25
60571
S
111422
S
5
0.46
68
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
2
10
110
675
5
0.1
Dichlorodifluoromethane
S
0.1
o-Dichlorobenzene
118525
111444
0.4
Ceiling(g)
Dichloroacetylene
75718
540590
0.2
1,2-Dibromo-3-chloropropane; DBCP; see
Section 5212
Dibromodifluoromethane; see
Difluorodibromomethane
1,2-Dibromomethane; see Ethylene
dibromide, Section 5219
2-N-Dibutylaminoethanol
Dibutyl phosphate
95501
PEL (d)
mg/M3(f)
Dibutyl phenyl phosphate
107664
7572294
PEL (d)
ppm(e)
30
2
6200 ppm
--
0.4
10
60
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
109897
S
112367
S
111966
100378
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
Diethylamine
5
15
Diethylene glycol diethyl ether,Ethyl diglyme
5
33
S
Diethylene glycol dimethyl ether, Diglyme
1
5.5
S
2-(Diethylamino) ethanol
2
9.6
1
4
200
705
123911
111400
S
Diethylenetriamine
Diethyl ether; see Ethyl ether
298044
96220
Di-(2-ethylhexyl) phthalate; see Di-sec-octyl
phthalate
Diethyl ketone
84662
Diethyl phthalate
75616
Difluorodibromomethane;
dibromodifluoromethane
Diglycidyl ether; DGE; bis(2,3-epoxypropyl)
ether
p-Dihydroxybenzene; see Hydroquinone
100
860
0.1
0.5
Diisobutyl ketone; 2,6-dimethyl-4-heptanone
25
150
5
20
2238075
123319
108838
S
108203
--
Diisopropylamine
Dimethylacetamide
Dimethylamine
60117
4-Dimethylaminoazobenzene, see Section
5209
Dimethylaminobenzene; see Xylidene
1300738
1057
S
N,N-Dimethylaniline; dimethylphenylamine
35
5
9.2
15
27.6
5
25
10
50
1.5
6.4
108849
1,3-Dimethylbutyl acetate; see sec-Hexyl
acetate
o,o-Dimethyl o-(1,2-dibromo-2,2dichloroethyl) phosphate; see Naled
Dimethylethoxysilane
0.5
2.1
S
Dimethylformamide; DMF
10
30
S
2,6-Dimethyl-4-heptanone; see Diisobutyl
ketone
1,1-Dimethylhydrazine
0.01
0.025
300765
14857342
108838
67641
Dimethyl ketone; see Acetone
62759
N,N-Dimethylnitrosamine; see NNitrosodimethylamine, Section 5209
Dimethyl phthalate
131113
77781
300
10
Dimethylbenzene; see Xylene
57147
27
5
1330207
68122
5
C
Dimethoxymethane; see Methylal
S
124403
121697
STEL (o)
mg/M3(f)
Diisopropyl ether; see Isopryl ether
109875
127195
STEL (o)
ppm(e)
1,4-Diethylene dioxide; see p-Dioxane
60297
108189
Ceiling(g)
S
148016
--
Dimethyl sulfate; methyl sulfate
5
0.1
Dinitolmide; 3,5-Dinitro-o-toluamide
--
0.5
5
528290,
S
Dinitrobenzene (all (isomers)
0.15
1
99650,
S
Dinitrobenzene ortho and meta isomers
0.15
1
100254
S
Dinitrobenzene para isomers
0.15
1
534521
S
4,6-Dinitro-o-cresol; 2-methyl-4,6dinitrophenol
--
69
0.2
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
PEL (d)
ppm(e)
25321146
S
2,4-Dinitrotoluene
--
123911
S
78342
S
p-Dioxane, tech. grade; 1,4dioxacyclohexane; 1,4-diethylene dioxide
Dioxathion
92524
Diphenyl; see Biphenyl
122394
Diphenylamine; N-phenylaniline
101688
Diphenylmethane diisocyanate; see
PEL (d)
mg/M3(f)
Ceiling(g)
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
150
900
6
15
0.15
25
90
--
0.2
--
10
Methylene bis(phenylisocyanate)
123193
34590948
Dipropyl ketone
S
85007
Dipropylene glycol methyl ether
50
235
100
600
Diquat; 1,1'-ethylene-2,2'-dipyridinium
dibromide Total dust
Diquat; 1,1'-ethylene-2,2'-dipyridinium
dibromide Respirable fraction(n)
Di-sec-octyl phthalate; bis(2 ethylhexyl)
phthalate
Disulfiram
--
0.5
--
5
--
2
--
0.1
128370
Disulfoton; o,o-diethyl S-2-(ethylthio)ethyl
phosphorodithioate
2,6-Di-tert-butyl-p-cresol
--
10
330541
Diuron
--
10
68122
DMF; see Dimethylformamide
57147
DMH; see 1,1-Dimethylhydrazine
1321740
Divinyl benzene
85007
117817
97778
298044
S
12415348
115297
S
72208
S
13838169
10
Dust, nuisance dust and particulates, see
Particulates not otherwise regulated
Emery; see Particulates not otherwise
regulated
Endosulfan; 6,7,8,9,10,10-hexachloro1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3benzodioxathiepin-3-oxide 8dimethanonaphthalene
Endrin; 1,2,3,4,10,10-hexachloro-6,7-epoxy1,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo5,
Enflurane
106898
S
Epichlorohydrin; 1-chloro-2,3-epoxypropane
2104645
S
75569
EPN; o-ethyl o-(p-nitrophenyl)
phenylphosphonothioate
1,2-Epoxypropane; see Propylene oxide
556525
2,3-Epoxypropanol; see Glycidol
74840
Ethane
75081
Ethanethiol; see Ethyl mercaptan
64175
Ethanol; see Ethyl alcohol
141435
Ethanolamine; 2-aminoethanol
50
--
0.1
--
0.1
2
15
0.05
0.19
--
0.1
(h)
--
3
--
8
563122
S
Ethion
110805
S
2-Ethoxyethanol
5
18
111159
S
2-Ethoxyethyl acetate
5
27
70
--
0.4
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
141786
140885
S
64175
75047
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
Ethyl acetate
400
1,400
Ethyl acrylate
5
20
1,000
1,900
Ethyl alcohol; ethanol
S
541855
Ethylamine
Ethyl sec-amyl ketone; 5-methyl-3heptanone
Ethylbenzene
100414
74964
Name(c)
S
106354
Ethyl bromide
9.2
130
100
435
5
22
50
230
Ethyl chloride; chloroethane
100
264
7085850
Ethyl cyanoacrylate
0.2
1.02
673923
Ethyl tert-butyl ether
74851
Ethylene
75003
107073
Ethyl butyl ketone; 3-heptanone
5
25
S
S
107153
106934
Ethylene chlorohydrin; 2-chloroethanol
Ethylenediamine; 1,2-diaminoethane
107062
Ethylene dibromide; 1,2-dibromoethane, see
Section 5219
Ethylene dichloride; 1,2-dichloroethane
107211
Ethylene glycol (vapor)
S
629141
S
110714
S
628966
S
110805
S
109864
S
110496
S
151564
S
Ethylene glycol diethyl ether, 1,2diethoxyethane
Ethylene glycol dimethyl ether,1,2dimethoxyethane, Glyme
Ethylene glycol dinitrate
100
125
545
75
345
2
8
5
18
21
--
1
3
10
25
0.13
1
C
200 ppm
1
4
40
100
5
24
1
3.7
C
C
--
0.1
1
2
5
Ethyl ether
400
1,200
500
Ethyl formate
100
300
109944
75343
Ethylidene chloride; see 1,1-Dichloroethane
16219753
Ethylidene norbornene
75081
Ethyl mercaptan; ethanethiol
5
25
0.5
1
5
23
1500
C
Ethyl methyl ketone; see Methyl ethyl ketone
S
N-Ethylmorpholine; 4-ethyl-1,4tetrahydrooxazine
Ethyl silicate; tetraethyl silicate
S
Fenamiphos
78104
115902
55389
25
1
60297
22224926
STEL (o)
mg/M3(f)
0.5
Ethylene oxide; see Section 5220
78933
STEL (o)
ppm(e)
C
(k)
Ethylene glycol monoethyl ether, see 2Ethoxyethanol
Ethylene glycol monomethyl ether, see 2Methoxyethanol
Ethylene glycol monomethyl ether acetate;
see 2-Methoxyethyl acetat
Ethyleneimine; see also Section 5209
75218
100743
5
(h)
Ceiling(g)
S
10
85
0.1
Fensulfothion
--
0.1
Fenthion
--
0.2
14484641
Ferbam; ferric N,N-dimethylthiocarbamate
--
10
12604589
Ferrovanadium dust
--
1
71
--
3
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
14808607
Name(c)
PEL (d)
ppm(e)
7782414
Fluorine
75694
75434
Fluorocarbon 11; see
Trichlorofluoromethane
Fluorocarbon 12; see
Dichlorodifluoromethane
Fluorocarbon 21; see Dichlorofluoromethane
75456
Fluorocarbon 22; see Chlorodifluoromethane
76120
Fluorocarbon 112; see 1,1,2,2-Tetrachloro1,2-difluoroethane
Fluorocarbon 113; see 1,1,2-Trichloro-1,2,2trifluoroethane
Fluorocarbon 114; see 1,2Dichlorotetrafluoroethane
Fluorotrichloromethane; see
Trichlorofluoromethane
Fonofos
75718
76131
75694
S
50000
--
S
0.2
--
0.1
0.75
--
2
Formamide
10
18
Formic acid
5
9
98011
S
Furfural
2
8
98000
S
Furfuryl alcohol
10
19
40
15
60
500
1500
500
2000
Gasoline
300
900
7782652
Germanium tetrahydride
0.2
0.6
0.2
10
Glass, fibrous
111308
Glutaraldehyde (t)
1.0
f/cc(q)
0.05
56815
123944
Glycerin mist; see Particulates not otherwise
regulated
Glyceryl stearate
--
556525
Glycidol; 2,3-epoxy-1-propanol
111762
Glycol monobutyl ether; see 2-Butoxyethanol
110805
Glycol monoethyl ether; see 2-Ethoxyethanol
109864
Glycol monoethyl ether; see 2Methoxyethanol
Grain dust (oat, wheat, barley)
7782425
Graphite, natural respirable dust
2
--
10
2.5
--
10
Graphite, synthetic Respirable fraction(n)
--
5
7440586
Gypsum; Calcium sulfate dihydrate; see
Particulates not otherwise regulated
Hafnium
--
151677
Halothane
822060
HDI; see Hexamethylene diisocyanate
7440597
S
C(u)
6.1
Graphite, synthetic Total dust
13397245
--
10
8006619
142825
STEL (o)
mg/M3(f)
2.5
0.1
Formaldehyde, see Section 5217
64186
76448
STEL (o)
ppm(e)
0.5(s)
Fluorides, as F
75127
Ceiling(g)
Fibrous glass, see Glass
Flour dust
944229
PEL (d)
mg/M3(f)
0.5
2
Helium
(h)
Heptachlor; 1,4,5,6,7,8,8-hepta-chloro3a,4,7,7a-tetrahydro-4,7-methanoindene
n-Heptane
--
-0.05
400
72
16
1,600
118741
S
Hexachlorobenzene
87683
S
Hexachlorobutadiene
--
0.002
0.02
73
0.24
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
77474
Name(c)
PEL (d)
mg/M3(f)
0.01
0.11
Hexachlorocyclopentadiene
67721
S
Hexachloroethane; perchloroethane
1335871
S
Hexachloronaphthalene
684162
S
Hexafluoroacetone; 1,1,1,3,3,3-hexafluoro-2propanone
Hexamethylene diisocyanate; HDI
S
n-Hexane
822060
110543
PEL (d)
ppm(e)
1
0.1
0.7
0.005
0.034
180
500
1800
124094
1,6-Hexanediamine
0.5
2.3
591786
2-Hexanone; see Methyl butyl ketone
592416
1-Hexene
50
180
108101
Hexone; see Methyl isobutyl ketone
108849
sec-Hexyl acetate; 4-methyl-2-pentyl
acetate; 1,3-dimethyl-butyl acetate
Hexylene glycol
50
300
S
Hydrazine
10035106
Hydrobromic acid; see Hydrogen bromide
7647010
Hydrochloric acid; see Hydrogen chloride
74908
Hydrocyanic acid; see Hydrogen cyanide
7664393
Hydrofluoric acid; see Hydrogen fluoride
1333740
Hydrogen
61788327
Hydrogenated terphenyls
10035106
7647010
74908
S
25
125
0.01
0.013
(h)
5
Hydrogen bromide
3
10
C
Hydrogen chloride; muriatic acid
5
7
C
4.7
5
C
Hydrogen fluoride, as F
3
2.5
7722841
Hydrogen peroxide, as H2O2
1
1.4
7783075
Hydrogen selenide, as Se
0.05
0.2
7783064
Hydrogen sulfide
10
14
123319
Hydroquinone; 1,4-benezendiol
S
--
2-Hydroxypropyl acrylate
0.5
3
Indene
10
48
7440746
Indium
--
Indium compounds
-0.1
1
75478
Iodoform
0.6
10
4098719
IPDI; see Isophorone diisocyanate
1309371
Iron oxide fume
13463406
Iron pentacarbonyl, as Fe
123513
--
21
0.2
1.6
125
450
C
5
0.1
--
0.8
1
100
74
15
0.1
Iodine
Isoamyl acetate; 3-methylbutyl acetate; see
Pentyl acetate
Isoamyl alcohol; 3-methylbutanol
50 ppm
--
0.1
7553562
123922
6
2
95136
Iron salts, soluble, as Fe
3600
--
7664393
999611
1000
C
0.5
Hydrogen cyanide
STEL (o)
mg/M3(f)
0.2
Hexane, other isomers
302012
STEL (o)
ppm(e)
10
--
50
107415
Ceiling(g)
360
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
110190
Isobutyl acetate; 2-methylpropyl acetate
78831
Isobutyl alcohol; 2-methylpropanol
26675467
Isoflurane
26952216
S
Isooctyl alcohol
S
Isophorone; 3,5,5-trimethyl-2-cyclohexene-1one
Isophorone diisocyanate; IPDI
78591
4098719
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
150
700
50
150
2
15
50
270
4
23
Ceiling(g)
STEL (o)
ppm(e)
0.005
0.045
109591
Isopropoxyethanol
25
105
108214
Isopropyl acetate
250
950
310
1185
67630
Isopropyl alcohol
400
980
500
1225
75310
Isopropylamine
5
12
10
24
75
360
1.5
3
768525
S
N-isopropylaniline
108203
Isopropyl ether; diisopropyl ether
4016142
Isopropyl glycidyl ether; IGE; 1,2-epoxy-3isopropoxypropane
Kaolin; (respirable dust containing no
asbestos and <1% crystaline silica)
Ketene; ethenone
1332587
463514
2
10
250
1,050
50
240
--
0.02
STEL (o)
mg/M3(f)
--
2
0.5
0.9
Lead arsenate, see Sections 5214 and 5198
7758976
78002
Lead chromate, as Pb (see also Section
5198, 1532.1, 1532.2, 5206 & 8359)
Lead chromate, as Cr (see also Section
5198, 1532.1, 1532.2, 5206 & 8359)
Lead (metallic) and inorganic compounds,
dust and fume, as Pb (see also Section
5198 )
Lead tetraethyl, see Tetraethyl lead
75741
Lead tetramethyl, see Tetramethyl lead
1317653
Limestone; calcium carbonate; see
Particulates not otherwise regulated
Lindane; 1,2,3,4,5,6-hexachlorocyclohexane,
gamma isomer
Lithium hydride
7758976
58899
S
7580678
--
0.02
--
0.005
--
0.05
--
0.5
--
L.P.G.; liquefied petroleum gas
0.025
1,000
1,800
4485125
Lithium stearate
--
10
13717005
1309484
Magnesite; magnesium carbonate; see
Particulates not otherwise regulated
Magnesium oxide fume, as Mg
--
10
557040
Magnesium stearate
--
10
Malathion; o,o-dimethyl S-1(1,2dicarboethyoxyethyl) phosphorodithioate
Maleic anhydride; cis-butenedioic anhydride
--
10
Manganese and compounds, as Mn
--
0.2
Manganese fume, as Mn
--
0.2
Manganese, cyclopentadienyl-tricarbonyl, a
Mn
Manganese tetroxide
--
0.1
--
0.2
121755
S
108316
7439965
12079651
S
0.1
Marble; calcium carbonate; see Particulates
not otherwise regulated
75
0.4
--
3
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
101779
S
MDA; see 4,4'-Methylene dianiline
101688
7439976
S
7439976
S
Mercury alkyls, as Hg
Mesitylene; see 1,3,5-Trimethylbenzene
141797
Mesityl oxide; 4-methyl-3-pentene-2-one
S
Methane
74931
Methanethiol; see Methyl mercaptan
--
0.025
--
0.01
15
20
(h)
0.04 mg/M3
--
STEL (o)
mg/M3(f)
0.1
0.03
mg/M3
C
25
100
250
760
1250
2250
250
325
15
19
70
Methanol; see Methyl alcohol
Methomyl
--
2.5
--
10
S
Methoxychlor; 1,1,1-trichloro-2,2-bis(pmethoxyphenyl)ethane
2-Methoxyethanol
5
16
2-Methoxyethyl acetate
5
24
76380
Methoxyflurane
2
13
150765
4-Methoxyphenol
79209
Methyl acetate
200
610
74997
Methyl acetylene; propyne
1,000
1,650
Methyl acetylene-propadiene mixture; MAPP
1,000
1,800
10
35
1
3
1,000
3,100
200
260
96333
S
Methyl acrylate
126987
S
alpha-Methylacrylonitrile
624419
--
5
2-Methylbutyl acetate; see Pentyl acetate
109875
Methylal; dimethoxymethane
S
Methyl alcohol; methanol
74895
Methylamine
5
6.4
108112
Methyl amyl alcohol; see Methyl isobutyl
carbinol
Methyl n-amyl ketone; 2-heptanone
50
235
N-Methylaniline; monomethylaniline
0.5
2
110430
100618
STEL (o)
ppm(e)
--
110496
67561
Ceiling(g)
60
S
72435
109864
0.01
Methacrylic acid
74828
67561
--
Mercury, metallic and inorganic compounds
as Hg
Mercury aryl compounds as Hg
108678
16752775
PEL (d)
mg/M3(f)
MDI; see Methylene bis(phenylisocyanate)
S
7439976
79414
PEL (d)
ppm(e)
S
95534
1000 ppm
o-Methylaniline; see o-Toluidine
74839
S
Methyl bromide
1
3.88
591786
S
Methyl butyl ketone; 2-hexanone
5
20
74873
Methyl chloride
71556
Methyl chloroform; 1,1,1-trichloroethane
107302
Methyl chloromethyl ether; see Section 5209
75058
Methyl cyanide; see Acetonitrile
137053
108872
25639423
Methylcyclohexanol (meta- and para-isomer
mixture)
20 ppm
50
105
300 ppm
100
210
350
1900
800 ppm
450
2450
Methyl 2-cyanoacrylate
0.2
0.908
Methylcyclohexane
400
1,600
50
235
76
4
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
583608
S
o-Methylcyclohexanone
12108133
S
8022002
S
101144
S
1338234
2-Methylcyclopentadienyl manganese
tricarbonyl, as Mn
Methyl demeton; a mixture of o,o-dimethyl o(2-(ethylthio)ethyl) phosphorothioate and
o,o-dimethyl S-(2-(ethylthio)-ethyl)
phosphorothioate
4,4'-Methylene bis(2-chloroaniline), see also
Section 5215
Methylene bis(4-cyclohexylisocyanate);
hydrogenated MDI
Methylene bis(phenylisocyanate); MDI;
diphenylmethane diisocyanate
Methylene chloride; dichloromethane (see
also section 5202)
4,4'-Methylene dianiline; MDA (see also
Sections 1535 and 5200 )
Methyl ethyl ketone; MEK; 2-butanone; ethyl
methyl ketone
Methyl ethyl ketone peroxide
0.2
1.5
107313
Methyl formate
100
250
0.01
0.019
5124301
101688
75092
101779
S
78933
60344
S
Methyl hydrazine; monomethyl hydrazine
74884
S
Methyl iodide
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
50
230
--
0.2
--
0.5
--
0.01
Ceiling(g)
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
75
345
0.005
0.054
0.005
0.051
25
87
125
435
0.01
0.08
0.1
0.8
200
590
300
885
150
375
C
2
10
Methyl isoamyl ketone
50
234
S
Methyl isobutyl carbinol; 4-methyl-2pentanol; methyl amyl alcohol
Methyl isobutyl ketone; Hexone
25
100
40
165
50
205
75
300
S
Methyl isocyanate
0.02
0.05
563804
Methyl isopropyl ketone
200
705
74931
Methyl mercaptan
0.5
1
80626
50
205
100
410
107879
Methyl methacrylate; methyl 2-methyl-2propenoate
Methyl parathion; o,o-dimethyl o-(pnitrophenyl) phosphorothioate
Methyl propyl ketone; 2-pentanone
200
700
250
875
681845
Methyl silicate; tetramethyl silicate
1
6
98839
50
240
100
485
77781
alpha-Methylstyrene; 1-methyl-1phenylethene
Methyl sulfate; see Dimethyl sulfate
1634044
Methyl tert-butyl ether; MTBE
40
144
21087649
Metribuzin
0.01
0.1
0.03
0.3
110123
108112
108101
624839
298000
7786347
7439987
7439987
S
S
--
0.2
--
Mevinphos; 2-carbomethoxyl-1-propen-2-yl
dimethyl phosphate
Mica, see Silicates
Mineral wool fiber; see Particulates not
otherwise regulated
Molybdenum, insoluble compounds, as Mo
Total dust
Molybdenum, insoluble compounds, as Mo
Respirable fraction (n)
Molybdenum, soluble compounds, as Mo
--
10
--
3
--
77
5
0.5(n)
Name(c)
PEL (d)
ppm(e)
6923224
Monocrotophos
--
100618
Monomethylaniline; see N-Methylaniline
60344
Monomethylhydrazine; see Methyl hydrazine
Chemical
Abstracts
Registry
Number
(a)
110918
Skin(b)
S
PEL (d)
mg/M3(f)
Morpholine; tetrahydro-4H-1, 4-oxazine
20
70
100
400
10
50
0.01
0.085
0.001
0.007
Muriatic acid; see Hydrogen chloride
8030317
Naphtha, coal tar
91203
Naphthalene
134327
25551284
alpha-Naphthylamine; 1-naphthylamine, see
Section 5209
beta-Naphthylamine; 2-naphthylamine, see
Section 5209
1-Naphthyl N-methylcarbamate; see
Carbaryl
Naphthalene diisocyanate; NDI
7440019
Neon
13463393
Nickel carbonyl; Ni (CO)4
7440020
Nickel metal, as Ni
--
Nickel, insoluble compounds, as Ni
--
1
Nickel, soluble compounds, as Ni
--
0.1
63252
54115
S
Nicotine; 1-methyl-2-(3-pyridyl)-pyrrolidine
0.075
10
1929824
Nitrapyrin Respirable fraction(n)
--
5
7697372
Nitric acid
10102439
Nitric oxide; NO
p-Nitroaniline
S
Nitrobenzene
100005
S
2
5
25
30
--
5
0.1
0.64
92933
p-Nitrochlorobenzene; 1-chloro-4nitrobenzene
4-Nitrodiphenyl, see Section 5209
79243
Nitroethane
100
310
7727379
Nitrogen
10102440
Nitrogen dioxide
7783542
Nitrogen tetroxide; N2O4; see Nitrogen
dioxide
Nitrogen trifluoride
S
(h)
Nitromethane
108032
10
4
10
1
1.8
C
29
(k)
--
2
5
1-Nitropropane
25
90
79469
2-Nitropropane
10
35
62759
N-Nitrosodimethylamine, see Section 5209
1321126,
S
Nitrotoluene
2
11
99081,
S
Nitrotoluene
2
11
88722,
S
Nitrotoluene
2
11
99990
S
Nitrotoluene
2
11
76062
75
--
Nitroglycerin
75525
15
3
1
55630
105
0.5
--
S
30
1
Nitrapyrin Total dust
98953
STEL (o)
mg/M3(f)
(h)
1929824
100016
STEL (o)
ppm(e)
0.25
7647010
91598
Ceiling(g)
Nitrotrichloromethane; see Chloropicrin
78
0.1
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
10024972
Nitrous oxide
111842
Nonane
2234131
Nuisance particulates, see Particulates not
otherwise regulated Total dust
Nuisance particulates, see Particulates not
otherwise regulated Respirable fraction(n)
Octachloronaphthalene
S
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
50
90
200
1,050
--
10
--
5
--
0.1
111659
Octane
8012951
Oil (mineral) mist, particulate
20816120
Oil (vegetable) mists (except castor, cashew
nut or similar irritant oils); see Nuisance
particulates
Organic arsenic compounds; see Arsenic,
organic
Osmium tetroxide, as Os
144627
Oxalic acid
7783417
Oxygen difluoride
10028156
Ozone
8002742
Paraffin wax fume
--
2
S
Paraquat, total particulates
--
0.5
S
Paraquat, respirable sizes
--
S
Parathion; o,o-diethyl o-(p-nitrophenyl)
phosphorothioate
Particulates not otherwise regulated Total
dust
Particulates not otherwise regulated
Respirable fraction(n)
Particulate polycyclic; aromatic
hydrocarbons (PPAH) see Coal tar pitch
volatiles
PCB; see Chlorodiphenyl
--
0.1
--
10
--
5
1910425,
2074502
1910425,
2074502
56382
87865
S
19624227
300
STEL (o)
ppm(e)
--
1,450
STEL (o)
mg/M3(f)
0.3
375
1800
0.0006
0.006
(5)(l)
--
0.0002
0.002
--
1
0.05
0.1
0.1
0.2
--
2
C
0.3
0.6
0.015
0.03
100
532
100
685
6
28
0.1(n)
PCP; see Pentachlorophenol
Pentaborane
0.005
0.01
1321648
S
Pentachloronaphthalene
--
0.5
87865
S
Pentachlorophenol; PCP
--
0.5
115775
Ceiling(g)
109660
Pentaerythritol; tetrakis(hydroxymethyl)methane; tetramethylolmethane; see Particulates not
otherwise regulated
Pentane
107879
2-Pentanone; see Methyl propyl ketone
628637, 626380,
123922, 625161,
620111, 624419
67721
Pentyl acetate
127184
594423
600
1,800
50
266
Perchloroethylene
25
170
0.1
0.8
7616946
Perchloromethyl mercaptan;
trichloromethanethiol
Perchloryl fluoride; C1O3F
3
14
382218
Perfluoroisobutylene
0.01
0.082
Perchloroethane; see Hexachloroethane
79
300 ppm
C
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
PEL (d)
ppm(e)
Perlite Total dust
--
Perlite Respirable fraction(n)
--
PEL (d)
mg/M3(f)
Phenol
92842
S
Phenothiazine; dibenzothiazine
--
5
106503
S
p-Phenylenediamine
--
0.1
100425
5
S
100630
S
108985
638211
1
7
Phenyl glycidyl ether, PGE;1,2-epoxy-3phenoxypropane
Phenylhydrazine
0.1
0.6
5
20
Phenyl mercaptan
0.5
2
0.05
0.25
Phenylphosphine
75445
Phorate; o,o-diethyl S(ethylthio)methylphosphorodithioate
Phosgene; carbonyl chloride; COCl2
7803512
Phosphine; PH3
7664382
Phosphoric acid
--
1
7723140
Phosphorus, yellow
--
0.1
10025873
Phosphorus oxychloride
10026138
Phosphorus pentachloride
1314803
Phosphorus pentasulfide; P2S5
7719122
Phosphorus trichloride
85449
Phthalic anhydride
626175
m-Phthalodinitrile
--
5
1918021
Picloram Total dust
--
10
S
Picloram Respirable fraction(n)
--
5
Picric acid; 2,4,6-trinitrophenol
--
0.1
1918021
88891
S
--
45
0.1
0.4
0.3
0.4
0.1
0.6
0.1
1
0.2
1.5
1
6
--
--
Pindone; 2-pivalyl-1, 3-indandione
Piperazine dihydrochloride
--
5
26499650
Plaster of Paris; calcium sulfate
hemihydrate; see Particulates not otherwise
regulated
Platinum, metal
--
1
Platinum, soluble salts, as Pt
--
0.002
--
--
1310583
--
2
593293
Potassium stearate
--
10
74986
Propane
S
(m)
1000
Propargyl alcohol; 2-propyn-1-o1
1800 (h)
1
2
57578
beta-Propiolactone, see Section 5209
0.5
1.5
79094
Propionic acid
10
30
80
3
0.5
Polychlorobiphenyls, see Chlorodiphenyl
C
1
3
--
0.1
Polytetrafluoroethylene, decomposition
products
Portland Cement; see Particulates not
otherwise regulated
Potassium hydroxide; caustic potash
0.2
1
1
142643
7440064
C
0.05
83261
107197
10
19
Phenylethylene; see Styrene
122601
298022
STEL (o)
mg/M3(f)
5
S
Phenyl ether, vapor
STEL (o)
ppm(e)
10
108952
101848
Ceiling(g)
3
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
114261
PEL (d)
ppm(e)
Propoxur; 2-isopropoxyphenyl Nmethylcarbamate
n-Propyl acetate
109604
71238
Name(c)
S
115071
Ceiling(g)
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
840
250
1050
500
250
625
110
510
0.5
200
n-Propyl alcohol
200
Propylene
78875
PEL (d)
mg/M3(f)
(h)
75
350
6423434
S
Propylene glycol dinitrate; PGDN
0.05
0.3
107982
S
Propylene glycol monomethyl ether
100
360
150
540
108656
S
Propylene glycol monomethyl ether acetate
100
541
150
811
75558
S
Propyleneimine; 2-methylaziridine
2
5
75569
Propylene oxide; 1,2-epoxy-propane
2
4.75
627134
n-Propyl nitrate
25
107
40
170
74997
Propyne; see Methylacetylene
8003347
Pyrethrum
110861
Pyridine
5
15
106514
Quinone
0.1
0.4
121824
RDX; see Cyclonite
108463
Resorcinol
20
90
7440166
Rhodium, metal
--
0.1
7440166
Rhodium, metal Insoluble compounds, as
Rh
Rhodium, metal Soluble salts, as Rh
--
0.1
--
0.001
Ronnel; o,o-dimethyl o-(2,4,5trichlorophenyl) phosphorothioite
Rosin core solder, pyrolysis products, as
formaldehyde
Rotenone, commercial
--
10
--
0.1
--
5
7440166
299843
83794
1309371
Propylene dichloride; 1,2-dichloropropane
--
--
5
10
Rouge; see Particulates not otherwise
regulated
Rubber solvent (Naphtha)
400
Selenium compounds, as Se
--
45
1,600
0.2
7783791
Selenium hexafluoride
136787
--
10
--
5
--
6
--
3
--
6
14464461
Sesone; sodium 2,4-dichlorophenoxyethylsulfate Total dust
Sesone; sodium 2,4-dichlorophenoxyethylsulfate Respirable fraction(n)
Silica, amorphous Diatomaceous earth Total
dust
Silica, amorphous Diatomaceous earth
Respirable fraction(n)
Silica, amorphous Diatomaceous earth
Precipitated and gel
Silica, crystalline Cristobalite, respirable dust
--
0.05
14808607
Silica, crystalline Quartz, respirable dust
--
0.1
14808607
Silica, crystalline Quartz, total dust
--
0.3
60676860
Silica, crystalline Silica, fused, respirable
dust
Silica, crystalline Tridymite, respirable dust
--
0.1
--
0.05
61790532
61790532
61790532
15468323
0.05
81
0.4
Name(c)
PEL (d)
ppm(e)
Silica, crystalline Tripoli, respirable dust
--
0.1
--
3
--
6
--
3
--
2
--
2
7803625
Silicates (<1% crystalline silica) Mica
(respirable dust)
Silicates (<1% crystalline silica) Soapstone,
total dust
Silicates (<1% crystalline silica) Soapstone,
respirable dust
Silicates (<1% crystalline silica) Talc
(containing asbestos); see Section 5208
Silicates (<1% crystalline silica) Talc
(containing no asbestos fibers), respirable
dust
Tremolite (containing no asbestos fibers),
respirable dust
Silicon; see Particulates not otherwise
regulated
Silicon carbide; SiC; see Particulates not
otherwise regulated
Silicon tetrahydride; silane
7440224
Silver metal, as Ag
--
0.01
Silver, soluble compounds, as Ag
--
0.01
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
1317959
PEL (d)
mg/M3(f)
Ceiling(g)
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
Silicates (<1% crystalline silica)
12001262
14807966
7440213
409212
5
7
Soapstone, see Silicates
26628228
S
Sodium azide
0.1
0.3
7631905
Sodium bisulfite
--
5
136787
Sodium 2,4-dichlorophenoxyethyl sulfate;
see Sesone
Sodium fluoroacetate
--
0.05
1310732
Sodium hydroxide; caustic soda
--
2
7681574
Sodium metabisulfite
--
5
822162
Sodium stearate
--
10
9005258
7789062
Starch; see Particulates not otherwise
regulated
Strontium chromate, as Cr (see also
Sections 1532.2, 5206 & 8359)
Stearates; see specific compound
--
0.0005
7803523
Stibine; SbH3
8052413
Stoddard solvent
57249
Strychnine
62748
100425
S
S
9014011
100
--
Styrene (monomer); phenylethylene
74222972
S
Sulfur dioxide
2551624
Sulfur hexafluoride
7664939
Sulfuric acid
0.15
0.5
525
215
500 ppm
100
425
0.00006(r
--
)
--
3.5
Sulfotep; tetraethyl dithionopyrophosphate
7446095
-C
0.15
50
Subtilisins (as pure crystalline proteolytic
enzymes)
Sucrose; see Particulates not otherwise
regulated
Sulfometuron methyl
57501
3689245
0.1
C
0.2
--
82
2
5
1,000
6,000
1
5
--
10
3
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
Ceiling(g)
10025679
Sulfur monochloride; S2Cl2
1
6
C
5714227
Sulfur pentafluoride; S2F10
0.01
0.1
C
7783600
Sulfur tetrafluoride
0.1
0.4
C
2699798
Sulfuryl fluoride; SO2F2
5
20
35400432
Sulprofos
93765
2,4,5-T;2,4,5-trichlorophenoxyacetic acid
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
10
40
250
735
1
--
10
Talc; see Silicates
7440257
Tantalum metal dust, as Ta
--
5
1314610
Tantalum oxide dust, as Ta
--
5
78308
TCP; see Triorthocresyl phosphate
584849
TDI; see Toluene-2,4-diisocyanate
3689245
S
TEDP; see Sulfotep
Tellurium and compounds, as Te
--
0.1
7783804
Tellurium hexafluoride
3383968
Temephos; o,o,o' ,o'-tetramethyl o,o'-thiodip-phenylene phosphorothioate Total dust
Temephos; o,o,o' ,o'-tetramethyl o,o'-thiodip-phenylene phosphorothioate Respirable
fraction(n)
TEPP; tetraethyl pyrophosphate;
--
10
--
5
Terephthalic acid
--
107493
S
100210
79276
76119
76120
79345
S
127184
56235
1335882
0.5
1,1,2,2-Tetrabromoethane; see Acetylene
tetrabromide
1,1,1,2-Tetrachloro-2,2-difluoroethane
500
4170
500
4,170
1
7
1,1,2,2-Tetrachloro-1,2-difluoroethane;
fluorocarbon 112
1,1,2,2-Tetrachloroethane; acetylene
tetrachloride
Tetrachloroethylene; see Perchloroethylene
5
--
2
S
--
0.075
C
Tetraethyl pyrophosphate; see TEPP
Tetrahydrofuran
S
Tetramethyl lead; tetramethylplumbane, as
Pb
Tetramethylolmethane; see Pentaerythritol
S
137268
Tetramethyl succinonitrile (decomposition
product of 2,2'-azobisisobutyronitrile)
Tetramethyl thiuram disulfide, see Thiram
509148
Tetranitromethane
115775
7722885
479458
10
Terphenyls
Tetraethyl dithionopyrophosphate; see
Sulfotep
Tetraethyl lead; tetraethylplumbane, as Pb
109999
3333526
0.05
S
107493
75741
0.004
0.2
Tetrachloromethane; see Carbon
tetrachloride
Tetrachloronaphthalene
3689245
78002
0.02
S
200
--
590
0.075
0.5
3
0.005
0.04
Tetrasodium pyrophosphate
--
5
Tetryl; 2,4,6-trinitrophenylmethylnitramine
--
1.5
83
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
PEL (d)
ppm(e)
S
Thallium, soluble compounds, as Tl
--
0.1
4,4'-Thiobis(6-tert-butyl-m-cresol) Total dust
--
10
4,4'-Thiobis(6-tert-butyl-m-cresol) Respirable
fraction(n)
Thioglycolic acid
--
5
109999
S
1
3.8
1
5
7719097
Thionyl chloride
137268
Thiram; bis(dimethylthiocarbamoyl) disulfide
--
5
Tin, organic compounds, as Sn
--
0.1
Tin, tin oxide and inorganic compounds,
except SnH4, as Sn
Titanium dioxide, as Ti; see Particulates not
otherwise regulated
TMTD; see Thiram
--
2
S
21651194
13463677
137268
118967
108883
Ceiling(g)
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
THF; see Tetrahydrofuran
96695
68111
PEL (d)
mg/M3(f)
C
--
0.2
TNT; see 2,4,6-Trinitrotoluene
S
584849
Toluene; toluol
Toluene-2,4-diisocyanate; TDI
50
188
500 ppm
150
560
0.02 ppm
0.02
0.15
100
537
1250
9500
0.005
0.04
108441
S
m-Toluidine
2
9
95534
S
o-Toluidine; o-methylaniline
2
9
106490
S
p-Toluidine
2
9
0.2
2.5
8001352
Toxaphene; see Chlorinated camphene
115866
TPP; see Triphenyl phosphate
Tremolite, nonasbestiform; see Silicates
75252
Tribromomethane; see Bromoform
126738
Tributyl phosphate
76039
Trichloroacetic acid
1
5
120821
1,2,4-Trichlorobenzene
5
40
50293
1,1,1,-Trichloro-2,2-bis(pchlorophenyl)ethane; see DDT
1,1,1-Trichloroethane; see Methyl chloroform
71556
79005
1,1,2-Trichloroethane
10
45
79016
Trichloroethylene; trichloroethene
25
135
75694
Trichlorofluoromethane; Fluorocarbon 11
1,000
5,600
67663
Trichloromethane; see Chloroform
594423
Trichloromethanethiol; see Perchloromethyl
mercaptan
Trichloronaphthalene
1321659
S
S
76062
Trichloronitromethane; see Chloropicrin
93765
96184
2,4,5-Trichlorophenoxyacetic acid see 2,4,5T
1,2,3-Trichloropropane
76131
1,1,2-Trichloro-1,2,2- trifluoroethane
78308
13121705
Tricresyl phosphate; see Triorthocresyl
phosphate
Tricyclohexyltin hydroxide; see Cyhexatin
102716
Triethanolamine
121448
S
--
10
60
1000
7600
C
2000 ppm
5
1
84
300 ppm
5
--
Triethylamine
C
4.1
C
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
Name(c)
112492
S
Triethylene glycol dimethyl ether, Triglyme
75638
Trifluorobromomethane
2451629
1,3,5-Triglycidyl-s-triazinetrione
552307
Trimellitic anhydride
75503
Trimethylamine
PEL (d)
ppm(e)
PEL (d)
mg/M3(f)
5
36
1,000
6,100
Ceiling(g)
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
15
36
0.005
Trimethylbenzene, all isomers
0.005
0.04
5
12
25
125
2
10
121459
Trimethyl phosphate
88891
2,4,6-Trinitrophenol; see Picric acid
479458
--
0.5
C
118967
S
2,4,6-Trinitrophenylmethyl nitramine; see
Tetryl
2,4,6-Trinitrotoluene; TNT
78308
S
Triorthocresyl phosphate
--
0.1
Triphenylamine
--
5
Triphenyl phosphate; TPP
--
3
Tungsten metal, as W
--
5
Tungsten, insoluble compounds, as W
--
5
--
10
Tungsten, soluble compounds, as W
--
1
--
3
--
0.6
603349
115866
S
7440337
8006642
Turpentine
100
Uranium (natural), insoluble compounds, as
U
Uranium (natural), soluble compounds, as U
110623
S
108054
100425
Vinylbenzene; see Styrene
593602
0.05
50
Vanadium pentoxide (V2O5), respirable dust
and fume
VC; see Vinyl chloride, Section 5210
Vegetable oil mists (except castor, cashew
nut or similar irritant oils); see Particulates
not otherwise regulated
Vinyl acetate
0.2
--
Valeraldehyde
1314621
75014
--
560
175
0.05(n)
--
10
30
20
Vinyl bromide; bromoethylene
5
75014
S
Vinyl chloride, see Section 5210
1
107131
S
Vinyl cyanide, see Acrylonitrile, Section 5213
100403
S
4-Vinyl cyclohexene
0.1
0.4
106876
S
Vinyl cyclohexene dioxide
0.1
0.57
75354
Vinylidene chloride; 1,1-dichloroethylene
75387
Vinylidene fluoride
25013154
Vinyltoluene
8030306
VM & P (Varnish Makers and Painters)
Naphtha
Warfarin; 3-(alpha-acetonyl-benzyl)-4hydroxycoumarin
Welding fumes; total particulates (see also
individual constituents)
Wood dust All soft and hard woods, except
Western red cedar
Wood dust, Western red cedar--
81812
85
1
4
100
262
50
240
300
1,350
--
0.1
--
5
--
5
--
2.5
--
15
45
400
1800
10
Chemical
Abstracts
Registry
Number
(a)
Skin(b)
1330207
Name(c)
PEL (d)
mg/M3(f)
100
435
300 ppm
0.1
C
Xylene; xylol; dimethylbenzene
1477550
S
m-Xylene-a,a'-diamine
1300738
S
Xylidine; aminodimethylbenzene
-0.5
Yttrium compounds, as Y
--
Zinc chloride fume
--
1
13530659
Zinc chromate, as Cr (see also Sections
1532.2, 5206 & 8359)
Zinc chromate hydroxide, as Cr (see also
Sections 1532.2, 5206 & 8359)
Zinc oxide fume
--
0.005
--
0.005
--
5
--
0.005
1314132
11103869
557051
37300235
Zinc oxide dust, see Particulates not
otherwise regulated
Zinc potassium chromate, as Cr (see also
Sections 1532.2, 5206 & 8359)
Zinc stearate
Zinc yellow, as Cr (see also Sections
1532.2, 5206 & 8359)
Zirconium compounds, as Zr
STEL (o)
ppm(e)
STEL (o)
mg/M3(f)
150
655
2.5
7646857
15930946
Ceiling(g)
PEL (d)
ppm(e)
1
--
10
--
0.005
--
5
--
2
--
10
--
10
Footnotes to Table AC-1
(a) The Chemical Abstracts Service Registry Number is a designation used to identify a specific compound or substance regardless of the
naming system; these numbers were obtained from the Desk Top Analysis Tool for the Common Data Base and from the Chemical Abstracts
Indexes.
(b) Refer to section 5155(d) for the significance of the Skin notation.
(c) Trade Names Removed from Table AC-1.
Trade Name Chemical/Generic Name
Abate
Ammate
Aqualin
Arasan
Azodrin
Baygon
Bidrin
Butyl Cellosolve
Cellosolve
Cellosolve Acetate
Compound 1080
Coyden
Crag Herbicide
Cythion
Dasanit
Delnav
Dibrom
Difolatan
Disyston
see
see
see
see
see
see
see
see
see
see
see
see
see
see
see
see
see
see
see
Temephos
Ammonium Sulfamate
Acrolein
Thiram
Moncrotophos
Propoxur
Dicrotophos
2-Butoxyethanol
2-Ethoxyethanol
2-Ethoxyethyl acetate
Sodium Fluoracetate
Clopidol
Sesone
Malathion
Fensulfothion
Dioxathion
Naled
Captafol
Disulfoton
86
Dowtherm A
Dursban
Dyfonate
Fermate
Freons
Furadan
Guthion
Korlan
Lannate
Mariate
MLT
Moxie
Nialate
Nankor
Phosdrin
Pival
Plictran
Santobrite
Sevin
Systox
Teflon
Thimet
Thiodan
Tordon
Trolene
Vapona
Weedone 638
Zoalene
see Phenylether and
Biphenyl
see Chloropyrifos
see Fonofos
see Ferbam
see Fluorocarbons
see Carbofuran
see Azinphos Methyl
see Ronnel
see Methomyl
see Methoxychlor
see Malathion
see Methoxychlor
see Ethion
see Ronnel
see Mevinphos
see Pindone
see Cyhexatin
see Pentachlorophenol
see Carbaryl
see Demeton
see Polytetrafluoroethylene
see Phorate
see Endosulfan
see Picloram
see Ronnel
see Dichlorvos
see 2, 4-D
see Dinitolmide
(d) For the definition and the application of the Permissible Exposure Limit (PEL), refer to section 5155(b) and (c)(1).
(e) Parts of gas or vapor per million parts of air by volume at 25oC and 760mm Hg pressure.
(f) Milligrams of substance per cubic meter of air at 25oC and 760mm Hg pressure.
(g) Refer to section 5155(b) and (c)(3) for the significance of the Ceiling notation. A "C" notation in this column means the values given in the
PEL columns are ceiling values. A numerical entry in this column represents a ceiling value in addition to the TWA values.
(h) A number of gases and vapors, when present in high concentrations, act primarily as asphyxiants without other adverse effects. A
concentration limit is not included for each material because the limiting factor is the available oxygen. (Several of these materials present fire
or explosion hazards.)
(i) Coal tar pitch volatiles (benzene or cyclohexane-soluble fraction) include fused polycyclic hydrocarbons (some of which are known
carcinogens) which volatilize from the distillation residues of coal, petroleum (excluding asphalt), wood, and other organic matter. Asphalt
(CAS 8052-42-4, and CAS 64742-93-4) is not covered under the "coal tar pitch volatiles" standard.
(j) This standard applies to the cotton waste processing operations of waste recycling (sorting, blending, cleaning, and willowing) and
garnetting. It does not apply to cotton gins, cottonseed oil industry, or operations covered by section 5190.
(k) A PEL of 0.05 ppm shall apply to exposures involying a mixture of ethylene glycol dinitrate and nitroglycerin.
(l) As sampled by method that does not collect vapor.
(m) Thermal decomposition of the fluorocarbon chain in air leads to the formation of oxidized products containing carbon, fluorine and
oxygen. An index of exposure to these products is possible through their alkaline hydrolysis followed by a quantitative determination of
fluoride content. No particular concentration limit is specified pending evaluation of the toxicity of the products but concentrations should be
kept below the sensitivity of the analytical method.
87
(n) The concentration and percentage of the particulate used for this limit are determined from the fraction passing a size selector with the
following characteristics:
Aerodynamic Diameter
in Micrometers
(unit density sphere)
≤2
2.5
3.5
5
10
Source: American Conference of Governmental Industrial Hygienists TLV Committee 1968 Proceedings.
(o) Refer to sections 5155(b) and (c)(2) for the definition and application of the Short Term Exposure Limit (STEL).
(p) (Reserved)
(q) Fibers per cubic centimeter of air at 25oC and 760mm Hg pressure. To be considered a fiber for this limit the glass particle must be longer
than 5µm, have a length to diameter ratio of three or more, and have a diameter less than 3µm. The National Institute for Occupational Safety
and Health (NIOSH), Method 7400, Issue 2, August 15, 1994, which is hereby incorporated by reference, shall be used for measuring
airborne fiber concentrations.
(r) Compliance with the subtilisins PEL is assessed by sampling with a high volume sampler (600-800 liters per minute) for at least 60
minutes.
(s) The concentration and percentage of the particulate used for this limit are determined from the fraction passing a size selector with the
following characteristics:
Aerodynamic Diameter
in Micrometers
(unit density sphere)
0
1
2
5
10
20
30
40
50
100
(t) Glutaraldehyde can cause occupational asthma and skin sensitization responses such as contact dermatitis. Exposure related symptoms
may include one or more of the following: shortness of breath, chest tightness, wheeze, cough, skin rash, hives, and irritation of the nose,
throat, skin or eye. Hazard communication training required by sections 5191 or 5194 shall address these health hazards and symptoms
along with the measures taken by the employer to evaluate and control exposures that can include medical evaluations, exposure monitoring,
ventilation systems, work practices, and personal protective equipment. The communication system required by section 3203 shall inform
employees where to report possible health symptoms and where to ask questions, report concerns, and receive information about the
employer’s evaluation and control measures.
(u) The Ceiling Limit of 0.05 ppm will take effect July 6, 2008. Until that time the following be in effect: PEL 0.05 ppm (8-hour time-weighted
average) Ceiling Limit 0.2 ppm.
NOTE: Authority cited: Section 142.3, Labor Code. Reference: Sections 142.3 and 144.6, Labor Code.
88
APPENDIX I
Signs and Symptoms of Select Agents and Toxins Used in Laboratories
(Extracted form Bioterrorism Response Card Published by New York State Department of Health May 2003)
Disease
Incubation
Period
1-7 days
(possibly up to
days)
Early Symptoms
Treatment
Prophylaxis
Non-specific: fever,
malaise, cough,
dyspnea, headache,
vomiting, abdominal
and chest pain.
Ciprofloxacin or
doxycycline, with or
without vaccination. If
susceptible, PCN or
amoxicillin should be
considered.
Cutaneous
Anthrax
1-12 days
Painless or pruritic
papule
Botulism
(Includes
Clostridium
Boulinum and
Botulinum
Toxin)
Foodborne: 1272 hours range,
2 hours – 8
days
Inhalational:
12-80 hours
Usually none. If
foodborne, possibly
nausea, vomiting,
abdominal cramps or
diarrhea.
Brucellosis
Very variable,
5-60 days
Fever (often
intermittent),
headache, chills,
heavy sweats,
arthralgias.
Equine
Encephaltides
(Eastern,
Western,
Venezuelan)
2-6 days,
Venezuelan 515 days, others
Pneumonic
Plague (Yersinia
pestis infection)
1-6 days
Non-specific: Sudden
onset o malaise,
fever, rigors, severe
headache,
photophobia,
myalgias of legs and
back.
Non-specific: high
fever, cough, chills,
dyspnea, headache,
hemoptysis, nausea,
vomiting, diarrhea.
Ciprofloxacin; doxycycline
Combination therapy of
ciprofloxacin or
doxycycline, plus one or
two other antimicrobials
should be considered with
inhalation anthrax. PCN
should be considered if
strain is susceptible.
Ciprofloxacin; doxycycline
Combination therapy of
ciprofloxacin or
doxycycline, plus one or
two other antimicrobials
should be considered with
inhalation anthrax. PCN
should be considered if
strain is susceptible.
Supportive care –
ventilation may be
necessary. Trivalent
equine antitoxin
(serotypes A, B, E –
available from CDC)
should be administered
immediately following
clinical diagnosis.
Doxycycline plus
streptomycin or rifampin.
Alternatives: ofloxacin
plus rifampin; doxycycline
plus gentamicin;
TMP/SMX plus
gentamicin.
Supportive care –
analgesics,
anticonvulsants as
needed.
Streptomycin; gentamicin.
Alternatives: doxycycline;
tetracycline; ciprofloxacin;
and chloramphenicol.
Tetracycline;
doxycycline;
ciprofloxacin
Inhalational
Anthrax
89
Ciprofloxacin or
doxycycline, with or
without vaccination. If
susceptible, PCN or
amoxicillin should be
considered.
None
Doxycycline plus
streptomycin or
rifampin
None
Signs and Symptoms of Select Agents and Toxins Used in Laboratories
(Extracted form Bioterrorism Response Card Published by New York State Department of Health May 2003)
Disease
Incubation
Period
10-40 days
Early Symptoms
Treatment
Prophylaxis
Fever, headache,
chills, heavy sweats,
arthralgias.
Tetracycline; doxycycline
Ricin (toxin from
castor bean oil)
18-24 hours
Smallpox
12 days;
range: 7-17
days
Supportive care.
Treatment for pulmonary
edema. Gastric
decontamination if toxin is
ingested.
Supportive care. Cidofovir
shown to be effective in
vitro.
Staphylococcal
enterotoxin B
3-12 hours for
inhalation.
Minutes to
hours for
ingestion.
Tularemia
(Francisella
tularensis
infection)
3-5 days;
range: 1-14
days
Viral
hemorrhagic
fevers (Ebola,
arenavirus,
filoviruses)
2-21 days;
varies among
viruses
Inhalation: fever,
weakness, cough,
hypothermia,
hypotension, cardiac
collapse.
Non-specific: fever,
malaise, headache,
prostration, rigors,
vomiting, severe
backache.
Inhalation: Fever,
chills, headache,
myalgias, cough,
nausea. Short
incubation and rapid
onset suggestive of
chemical agent.
Non-specific: fever,
fatigue, chills, cough,
malaise, body aches,
headache, chest
discomfort, GI
symptoms.
Fever, myalgias,
petechiae, easy
bleeding, red itchy
eyes, hematemesis.
Tetracycline;
doxycycline (may
delay but not prevent
illness).
None
Q fever (Coxiella
burnetii
infection)
90
Supportive care.
Vaccination given
within 3-4 days of
exposure can prevent
or decrease the
severity of disease.
None
Streptomycin; gentamicin.
Alternative: ciprofloxacin
Tetracycline;
doxycycline;
ciprofloxacin
Supportive care. Ribavirin
may be effective for
Lassa fever, CongoCrimean hemorrhagic
fever, Rift Valley fever.
Ribavirin may be
effective for Lassa
fever, CongoCrimean hemorrhagic
fever, Rift Valley
fever.
APPENDIX J
Risk Assessment of Work with Toxin and Determination of Personal Protective Equipment
(Revised 04/21/2011)
Description of agents:
Botulinum toxin, described as Level II agents (non-airborne). Dr. Lin is listed as the “Principal Investigator.”
Risk Assessment of Toxin
The following table lists the probability of exposure occurrence, consequences of exposure, and recommended protective
measures. The probability of exposure occurrence is rated as low, moderate or high based on the use and probability of the
exposure occurring. The consequences of exposure are rated as low, moderate or high based on the following:



Low level means the exposure identified would have little or no probability for harm.
Moderate level means the exposure identified may have some probability for harm.
High level means the exposure identified is likely to cause harm.
Any use with any of the following ratings for the probability of exposure occurrence and consequences of exposure was
considered significant and recommended protective measures are listed:




Moderate Probability of Exposure and Moderate Consequence of Exposure
High Probability of Exposure and Moderate Consequence of Exposure
Moderate Probability of Exposure and High Consequence of Exposure
High Probability of Exposure and High Consequence of Exposure
The recommended protective measures are determined based on the risk assessment of how the toxin is used. It should be
noted that probability and consequences may vary due to the type of use of the toxin.
Use
Agent Specific Risk Assessment: Botulinum Toxin
□ Low risk includes agents that are handled in a
diagnostic, nonpropagative manner (e.g., single
specimen, no culture).
□ Moderate risk includes agents that are handled in a
diagnostic, propagative manner. This level includes
only the amounts necessary for experiments at hand
(e.g., specimen cultured for diagnostic purposes or
produced only in amounts required for the research
or experiments being conducted).
□ High risk includes agents that are handled in large or
highly pure quantities such as liters or grams. It
would also include those agents and toxins used in
restricted experiments or experiments that may
increase virulence, and also includes high-risk use
(e.g., centrifugation).
Amount of Toxin Used Relative to Lethal Dose (LD):
May Exceed LD
Physical state of the toxin (solution or dry form):
Solution
Probability of
Exposure
Occurrence
Moderate
Consequences of
Exposure
Low
High
Low
High
91
High
Recommended
Protective
Measures
Use Biosafety
Level 2 practices
including the use
of a Biosafety
Cabinet for
manipulations of
the liquid.
Volume of the Material Manipulated: Microliters
methodology
Low
Moderate
Aerosolization of Toxin Given Physical State and
Volume Used
Is Controlled generation of aerosols Used for Testing:
No
Are Pressurized Containers Used: No
Is the Toxin Injected (e.g. Into Animals): Yes
Low
Moderate
Low
High
Low
High
High
High
Is Glass Used to Store or Handle the Toxin: Yes,
Hungate Culture Tubes Only
Moderate
High
Decontamination of Non-Disposable Laboratory Coats
prior to sending out for laundry.
High
Moderate
92
Train individuals
on animal
injection
techniques with
non-toxic
materials and
demonstrate
proficiency prior
to actual work.
Include broken
glassware clean
up procedures in
SOPs and
Biosafety Plan.
Consider
replacement of
glass Hungate
Tubes with
plastic.
Non-Disposable
laboratory coats
will be soaked in
500 ppm bleach
for a minimum of
20 minutes.
APPENDIX K
California State Polytechnic University, Pomona
Certification of Annual Review of Chemical Safety Plan for Laboratories
Signature of Reviewer
Date of Review
93