Licensing Opportunity
from the University of Rhode Island
Nanofibrous Biocomposite Prosthetic Vascular Graft
Description of Invention: The present invention provides a bioactive, small-diameter (typically less
than 6 mm in internal diameter) vascular graft prosthesis, and is a textile conduit preferably manufactured
using a novel electrospinning perfusion methodology. One preferred embodiment is a nanofibrous
biocomposite textile conduit which comprises a prepared liquid admixture of polyester (Dacron), a biodurable
implantable synthetic polymer, and Type IV collagen, an extracellular matrix protein. This prepared admixture
and blending of diverse fibrous matter is utilized in a novel electrospinning perfusion process to form a smalldiameter (less than 6 mm) fabricated textile conduit, a discrete article of manufacture, which then serves as
an antecedent tangible workpiece for a subsequently-made prosthetic vascular graft construct.
Potential Areas of Application:
1) The present invention is concerned generally with vascular prostheses; and is particularly directed to
the manufacture and use in-vivo of a nanofibrous vascular prosthesis (especially having channels
less than 6 mm internal diameter size) that is capable of emulating the biological and physical
properties of the native blood vessel wall.
Main Advantages of Invention:
1) A first aspect provides a fabricated textile conduit useful as a tangible workpiece for the manufacture
of a prosthetic vascular graft construct
2) A second aspect of the present invention is a prosthetic vascular graft construct useful as a synthetic
blood vessel in-vivo
3) A third aspect includes a method for making a fabricated textile conduit useful as an antecedent
workpiece for the manufacture of a prosthetic vascular graft construct
Lead Inventor:
Matthew Phaneuf et al
Status:
US patent application 11/211,935 filed August 25, 2005 issued as US 7,413,575 on August 19, 2008
Nanofibrous Biocomposite USPTO Website Link
Publications (with links):
Category: Biological, Pharmaceutical, Life Sciences
Licensing Status:
Available for licensing
Reference #:04-0820
Please contact David R. Sadowski or Raymond Walsh - Division of Research & Economic Development, University of Rhode Island,
75 Lower College Rd. Suite 001, Kingston, RI 02881; 401-874-4807 or Fax 401-874-7832
http://www.uri.edu/research/tro/executive/sadowski.html
Rev. 01-14-10