PRESS RELEASE / PRESSEINFORMATION
December 8, 2015
Instantly see the true nature with HyVolution for confocal microscopy
Leica TCS SP8 with HyVolution for greatest fidelity in multicolor confocal imaging
Mannheim, Germany. Leica Microsystems launches the HyVolution true confocal super-resolution
technology for the Leica TCS SP8 confocal microscope platform, extending its imaging portfolio in the
sub-diffraction regime. HyVolution allows researchers to achieve everything at the same time: They can
resolve structures down to 140 nm with multiple colors, with high imaging speed, and high signal-to-noise
ratio. HyVolution can be ordered with every new Leica TCS SP8 and is also available as an upgrade to
existing Leica TCS SP8 platforms.
“HyVolution is high-fidelity imaging for every sample and every experiment. When studying rapid
dynamics of living cells, researchers do not have to make a trade-off between high resolution, imaging
speed and the number of colors they want to acquire. For the first time, these parameters are available
with maximum efficiency at the same time in a confocal microscope. This opens new areas for
researchers,” says Markus Lusser, President of Leica Microsystems.
“Functional annotations of the genome require a deep insight into signaling networks. This often demands
sub 200 nm resolution with multiple dye emissions. HyVolution bridges the gap between classic confocal
imaging and STED super-resolution below 30 nm,” explains Dr. Bernd Sägmüller, Director Confocal
Laser Scanning Microscopy at Leica Microsystems. “HyVolution offers users multicolor super-resolution
down to 140 nm with a confocal microscope at an affordable price.”
HyVolution is based on combinations of the unique Leica HyD hybrid detectors, a workflow-oriented
software wizard, best-in-class Huygens deconvolution software embedded via a direct interface in the
Leica Application Suite X (LAS X) control software and CUDA GPU-accelerated computing. Researchers
benefit from HyVolution by imaging fast dynamic processes and capturing multiple colors simultaneously
with the spectral detection system of the Leica TCS SP8 and still achieve 140 nm resolution.
HyVolution technology was previewed at the annual meeting of the Society for Neuroscience (SfN) 2015
in Chicago, Illinois, October 17-21. Visitors could also see the integrated light sheet microscope Leica
TCS SP8 DLS, the Leica TCS SP8 STED 3X super-resolution microscope with an upright microscope
stand, and the Leica TCS SP8 MP multiphoton microscope.
Claudia Müller / Anja Schué· Tel. +49 6441 29-2630 / -2201· corporate.communications@leica-microsystems.com
Leica Microsystems GmbH · Ernst-Leitz-Straße 17–37 · D-35578 Wetzlar · www.leica-microsystems.com
PRESS RELEASE / PRESSEINFORMATION
Caption:
Instantly see the true nature. Left:
The ring structure of the basal
bodies of cilia in Paramecium are
easily resolved with HyVolution on
a Leica TCS SP8, but not with
traditional
Sample
confocal
courtesy
imaging.
of
Anne
Aubusson-Fleury, CNRS, Gif-surYvette, France. Right: HyVolution
resolves a nanoruler such as DNA
origami that has a defined 140 nm
fluorophore spacing.
More information about HyVolution: www.leica-microsystems.com/pr_hyvolution
An image gallery with HyVolution images: www.leica-microsystems.com/sciencelab_hyvolution
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About Leica Microsystems
Leica Microsystems develops and manufactures microscopes and scientific instruments for the analysis
of microstructures and nanostructures. Ever since the company started as a family business in the
nineteenth century, its instruments have been widely recognized for their optical precision and innovative
technology. It is one of the market leaders in compound and stereo microscopy, digital microscopy,
confocal laser scanning microscopy with related imaging systems, electron microscopy sample
preparation, and surgical microscopes.
Leica Microsystems has seven major plants and product development sites around the world. The
company is represented in over 100 countries, has sales and service organizations in 20 countries, and
an international network of distribution partners. Its headquarters are located in Wetzlar, Germany.
Claudia Müller / Anja Schué· Tel. +49 6441 29-2630 / -2201· corporate.communications@leica-microsystems.com
Leica Microsystems GmbH · Ernst-Leitz-Straße 17–37 · D-35578 Wetzlar · www.leica-microsystems.com