Table S1. Population- and family-based association studies of bipolar disorder and the BDNF Val66Met polymorphism
Number of
Study
Diagnostic
Val Allele
Study
Ethnicity
Cases/Controls
Odds Ratio (95% CI) d P value e
Design a
Criteria b
Frequency c
or Families
European/European
descent:
Sklar 2002
FAM
USA (Hopkins)
RDC
136
0.83
1.56 (1.01-2.40)
0.042
Sklar 2002*
FAM
USA (NIMH)
RDC
189
0.80
1.27 (0.89-1.81)
0.18
Sklar 2002
FAM
British Caucasian
DSM-IV
145
0.83
1.19 (0.74-1.90)
0.47
Geller 2004
FAM
USA
DSM-IV
53
0.79
2.33 (1.07-5.09)
0.014
Oswald 2004
CC
Belgian
DSM-IV
108/158
0.79
0.89 (0.59-1.35)
0.94
Skibinska 2004
CC
Polish
DSM-IV
352/375
0.82
1.13 (0.86-1.49)
0.41
Lohoff 2005*
CC
USA
DSM-IV
621/998
0.79
1.22 (1.02-1.47)
0.028
Neves-Pereira 2005 CC
Scottish
DSM-IV
263/350
0.78
1.07 (0.81-1.41)
0.54
Schumacher 2005
CC
German
DSM-IV
281/1097
0.81
1.01 (0.80-1.28)
0.92
Green 2006
CC
British Caucasian
DSM-IV
962/2100
0.81
1.06 (0.92-1.22)
0.39
†
Muller 2006
FAM
Canadian
DSM-IV
312
0.77
1.63 (1.21-2.19)
0.001
WTCCC 2007**
CC
British
RDC
1866/2932
0.80
1.11 (0.97-1.19)
0.17
Sklar 2008
CC
American+British
DSM-IV+RDC 1461/2008
0.83
0.97 (0.85-1.10)
0.61
Asian:
Nakata 2003
CC
Japanese
DSM-IV
130/190
0.58
1.02 (0.74-1.41)
0.94
Kunugi 2004
CC
Japanese
DSM-IV
519/588
0.60
0.98 (0.83-1.16)
0.83
Hong 2004
CC
Chinese
DSM-IV
108/392
0.52
1.12 (0.83-1.52)
0.49
Tang 2008
CC
Chinese
DSM-IV
197/208
0.56
1.18 (0.88-1.56)
0.285
Other:
Kremeyer 2006
FAM
Columbian
DIGS
212
0.70
1.40 (0.79-2.49)
0.001
* Overlapping samples obtained from the NIMH Bipolar Disorder Genetics Consortium.
** Partly overlapping sample with Green et al. 2006 and Neves-Pereira et al. 2005.
† Same patient sample reported by Neves-Pereira et al. 2002, from which the Val66Met allele frequency was obtained.
a CC = population-based case-control study; FAM = family-based study.
b RDC = Research Diagnostic Criteria (Spitzer et al. 1978); DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, 4 th edition (American
Psychiatric Association 1994); DIGS = Diagnostic Interview for Genetic Studies (Nurnberger et al. 1994).
c Frequency of the ancestral Val allele calculated from controls (for CC studies) or parents (for FAM studies).
d Pooled odds ratios and 95% confidence intervals for the Val allele versus the Met allele calculated from data reported in each study according to
the DerSimonian-Laird random-effects model (DerSimonian and Laird 1986; Mantel and Haenszel 1959).
e Two-tailed P values reported in each study.
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