Ocular and Systemic diseases associated with pain in and around the eye Hadley Saitowitz, OD Case 1: A 70-year-old white male presents with double vision and pain of 2-day duration. Clinical evaluation reveals a right upper lid ptosis, mid dilated pupil and down and out presentation in primary gaze. Diagnosis: Pupil involved third nerve palsy Case 2: A 45-year-old male presents with pain on side of face of 1-day duration with left sided numbness. Clinical evaluation reveals a right upper lid ptosis, miotic pupil greater in dim illumination. Diagnosis: Carotid dissection Case 3: A 75 year old white female presents with 2 day onset of pain on left forehead with radiation to temporal and occipital lobe. Clinical evaluation reveals a vesicular skin eruption in the region of frontal lobe, with a red eye. Diagnosis: Herpes Zoster Virus Case 4: A 76-year-old white male presents with a headache of 3-day duration, with tenderness and swelling in the region of his temporal lobe. He also reports a transient visual loss, which occurred that day which prompted his visit. Diagnosis: Temporal Arteritis Case 5: A 25-year-old white female presents with blurred vision and pain on eye movements of 1-week duration. Clinical evaluation reveals a positive relative afferent papillary defect, red desaturation greater on the affected side and reduced color vision. Diagnosis: Optic Neuritis Case 6: A 60-year-old white female presented with focal tenderness and swelling in her right peri-orbital region. She reports pain with eye movements. Her medical history is notable for recurrent sinus infections. Diagnosis: Preseptal cellulitis secondary to sinusitis. Case 7: A 55-year-old white male presents with a painful left eye of 2 days duration. One week prior to this he had been seen in the emergency room with a metallic foreign body, which had been removed without complication. His previous ocular history was notable for bilateral lasik, 6 years ago. Clinical evaluation revealed a diffuse stromal haze with mild injection. Diagnosis: Diffuse Lamellar Keratitis Case 8: A 30-year-old white female with a history of contact lens wear presents with pain, photophobia and reduced vision since removing her lenses the previous night. Clinical examination reveals a large epithelial defect with sodium flourescein staining. Diagnosis: Contact lens related corneal abrasion Case 9: A 40-year-old white male presents with pain, photophobia and reduced visual acuity on awakening this morning. He has a history of 30 day extended wear contact lenses, which were last replaced 10 days ago. Clinical examination reveals a central epithelial defect with underlying infiltrate and anterior chamber reaction. Diagnosis: Microbial keratitis Case 10: A 77-year-old white male presents with a painful right eye of 1-day duration. His previous ocular history is notable for filtering surgery for uncontrolled glaucoma. Clinical evaluation reveals a thin microcystic bleb with injection and positive seidel sign. Diagnosis: Blebitis Case 11: A 25-year-old white male presents with pain in his right eye on awakening. He reported a history of kerataconus and wears piggyback contact lenses. Clinical evaluation revealed central corneal edema with a raised nodule and overlying punctate staining. Diagnosis: Corneal Hydrops Case 12: A 40-year-old white male presents with pain, photophobia and blurred vision of 5 days duration. Clinical evaluation reveals circumlimbal injection, grade 2 cells and flare. Diagnosis: Anterior Uveitis