Forging a New Periodic Table Using Nanostructures Researchers in nanotechnology and its application have developed a completely new set of building blocks. These blocks are based on nanoparticles and DNA. They can use these new tools to build structures in the same way nature does. These new structures can be built from the particle level. Instead of taking what nature gives us, researchers can build new and useful structures. They will be able to control every property of the new material. People have always had a vision of building a new material from the particle level. They have wanted to shape matter from the most basic beginnings and control its architecture as it grows upwards. Researchers have shown this can be done. Using nanoparticles and DNA researchers built more than 200 different crystal structures with 17 different particle arrangements. Some of the lattice types can be found in nature, but many were new structures that have no naturally occurring mineral counterpart. Researchers can make new materials and arrangements of particles by controlling the size, shape, type and location of nanoparticles within a given particle lattice. They have developed a set of design rules that allow them to control almost every property of a material. New materials developed using his method could help improve the efficiency of optics, electronics and energy storage technologies. These same 1 nanoparticle building blocks have already found wide-spread commercial applications in biology and medicine as diagnostic probes for markers of disease. The present advances in nanoparticles allow researchers to build structures in a new way. Now, researchers start with a nanoparticle, which could be gold, silver, platinum or a quantum dot, for example. The core material is selected depending on what physical properties the final structure should have. They then attach hundreds of strands of DNA (oligonucleotides) to the particle. These small bits of nucleic acids can be manufactured with any user-specified sequence. The DNA sequence and length determine how bonds form between nanoparticles. The DNA guide the formation of specific crystal lattices. This constitutes a completely new class of building blocks in materials science that gives researchers a type of programmability that is extraordinarily versatile and powerful. The process gives nanotechnologists for the first time the ability to tailor properties of materials in a highly programmable way from the bottom up. 2