Pediatric Hematopathology Rotation - Goals and Objectives Pediatric Hematopathology Goals The overall goals of this rotation are for the fellow to: 1. Develop a rational and systematic approach to the morphological interpretation and diagnosis of pediatric hematopathology specimens including peripheral blood, bone marrow aspirates and biopsies, lymph node biopsies, and related hematology surgical pathology specimens. (medical knowledge, patient care, systems-based practice, interpersonal and communication skills, practice-based learning and improvement) 2. Correlate clinical information with morphological interpretation to formulate a differential diagnosis of pediatric hematopathology specimens. (medical knowledge, patient care, systems-based practice) 3. Integrate morphological interpretation with data from immunophenotyping, cytogenetics, and molecular diagnostics to help diagnose and accurately classify pediatric hematopoietic neoplasms (medical knowledge, patient care, systems-based practice, interpersonal and communication skill) Specific Objectives After completing this rotation, the fellow will be able to: 1. Diagnose and classify acute leukemia in pediatric patients. (medical knowledge, patient care, systems-based practice) 2. Diagnose and classify malignant lymphoma in pediatric patients. (medical knowledge, patient care, systems-based practice) 3. Describe and interpret specialized flow cytometry panels for pediatric cases of leukemia and lymphoma. (medical knowledge, patient care, systems-based practice, interpersonal and communication skills) 4. Describe and interpret specialized molecular diagnostic tests for pediatric cases of leukemia and lymphoma. (medical knowledge, patient care, systems-based practice, interpersonal and communication skills) 5. List and interpret cytochemical stains used in the diagnosis of pediatric cases of acute leukemia. (medical knowledge, patient care, systems-based practice) 6. List and interpret immunohistochemical stains used in the diagnosis of pediatric cases of malignant lymphoma and acute leukemia. (medical knowledge, patient care, systemsbased practice) 7. Correlate cytogenetic abnormalities with prognosis in pediatric acute leukemia. (medical knowledge, patient care, systems-based practice) Pediatric Hematopathology Rotation - Goals and Objectives 8. Explain the use of gene expression microarrays to classify pediatric acute leukemia and to determine prognosis. (medical knowledge, patient care, systems-based practice, practiced-based learning and improvement) 9. List the indications for bone marrow transplantation in pediatric patients. (medical knowledge, patient care, systems-based practice) 10. Interpret post-transplantation bone marrow specimens for engraftment and the presence of minimal disease using morphology, cytogenetics, and molecular diagnosis. (medical knowledge, patient care, systems-based practice)