Program Director/Principal Investigator (Last, First, Middle)
: Zhang, Jie
NAME
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
Jie Zhang
POSITION TITLE
Assistant Professor eRA COMMONS USER NAME (credential, e.g., agency login)
JSZHANG79
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)
INSTITUTION AND LOCATION
Sichuan University, Chengdu, Sichuan, China
University of Kentucky, Lexington, KY
University of Alabama at Birmingham,
Birmingham, AL
DEGREE
(if applicable)
BA
MPH
PhD
MM/YY
08/2002
05/2005
05/2010
FIELD OF STUDY
Medical English
Epidemiology
Epidemiology
NOTE: The Biographical Sketch may not exceed four pages. Follow the formats and instructions below.
A. Personal Statement
I received a doctoral degree in epidemiology from the University of Alabama at Birmingham and completed postdoctoral training in pharmacoepidemiology at the same institution. Most of my research has focused on outcomes in patients with rheumatic diseases using observational data. During my post-doctoral training, I have developed a strong interest in the utilization of administrative claims data for clinical research. These data contains valuable information for each patient-doctor encounter for tens of thousands of patients and are powerful tools to answer many of the research questions related to the use, safety and effectiveness of medications. I am particularly interested in methods to use such data for pharmacoepidemiologic research.
B. Positions and Honors
ASBMR President’s Poster Competition Award, American Society for Bone and Mineral Research Annual
Meeting, San Diego, US (2011)
Promising Investigator Award, University of Kentucky, (2005, one award per year for all MPH graduates)
Epidemiology Departmental Award, University of Kentucky, (2005, one award per Department)
C. Selected Peer-reviewed Publications (ordered on relevance to the proposed research)
Zhang J, Xie F, Delzell E, Chen L, Winthrop K, Lewis JD, Saag KS, Baddley J, Curtis JR. Association between vaccination for herpes zoster and risk of herpes zoster infection among older patients with selected immune-mediated diseases. JAMA . 2012 Jul 4; 308(1): 43-9.
Zhang J , Delzell E, Xie F, Baddley J, Spettell C, McMahan R, Fernandes J, Chen L, Winthrop K, Curtis JR.
The Use, Safety and Effectiveness of Herpes Zoster Vaccination in Individuals with Inflammatory and
Autoimmune Diseases. Arthritis Therapy and Research , 2011 Oct 24;13(5):R174 .
PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page

Program Director/Principal Investigator (Last, First, Middle)
: Zhang, Jie
Moreland LW, O’Dell JR, Paulus HE, Curtis JR, Bathon JM, St.Clair EW, Bridges L, Jr., Zhang J, McVie T,
Howard G, van der Heijde D, Cofield SS. A Randomized Comparative Effectiveness Study of Oral Triple
Therapy versus Etanercept plus Methotrexate in Early, Aggressive Rheumatoid Arthritis. Arthritis and
Rheumatism, 2012 Apr 16 [Epub ahead of print] .
Saag KG, Mohr PE, Esmail L, Wright NC, Curtis JR, Cutter G, Delzell E, Gary LC, Lewis CE, Harrington TM,
Jester P, Karkare S, Kilgore ML, Moloney R, Mudano AS, Oliveira A, Singh J, Warriner A, Zhang J , Berger M,
Cummings SR, Pace W, Solomon DH, Wallace R, Tunis SR. Improving the Efficiency and Effectiveness of
Pragmatic Clinical Trials in Older Adults . Contemp Clin Trial, 2012 Nov;33(6):1211-6.
Zhang J, Delzell E, Zhao H, Laster A, Saag KG, Kilgore ML, Morrisey MA, Wright NC, Yun H, Curtis JR. DXA
Utilization among Medicare Beneficiaries in the Wake of Reimbursement Changes. Journal of Bone and
Mineral Research, 2012 Apr; 27(4):858-64.
Wright NC , Curtis JR , Saag KG , Smith WK, Kilgore ML, Morrisey MA, Yun H, Zhang J , Delzell E. Recent
Trends in Hip Fracture Rates by Race/Ethnicity among Older US Adults.
J Bone Miner Res.
2012 Jun 12.
[Epub ahead of print]
Zhang J , Shan Y, Reed G, Kremer J, Greenberg J, Baumgartner S, Curtis JR. Thresholds in Disease Activity for Switching Biologics in RA Patients: Experience from a Large United States Cohort. Arthritis Care and
Research , 2011 Dec;63(12):1672-9.
Zhang J , Redden D, McGwin G, Callahan LF, Smith EA, Alarcón GS, Moreland LW, van der Heijde DM,
Brown E, Arnett DK, Mikuls TR, and Bridges L for the CLEAR Investigators. Generalized Bone Loss as a
Predictor of 3-Year Radiographic Damage in African American Patients with Recent-Onset Rheumatoid
Arthritis. Arthritis & Rheumatism , 2010 Aug;62(8):2219-26.
Zhang J , González L, Roseman JM, Vilá LM, Reveille JD, and Alarcón GS. Predictors of the Rate of Change in Disease Activity over Time in LUMINA, a Multiethnic US Cohort of Patients with Systemic Lupus
Erythematosus: LUMINA LXX. Lupus, 2010; 19(6): 727-33.
Pons-Estel GJ, Alarcón GS, González LA, Zhang J, Vilá LM, Reveille JD, McGwin G Jr; Lumina Study Group.
Possible protective effect of hydroxychloroquine on delaying the occurrence of integument damage in lupus:
LXXI, data from a multiethnic cohort. Arthritis Care Res (Hoboken), 2010 Mar; 62(3): 393-400.
González L, Pons-Estel G, Zhang J , McGwin G Jr, Roseman J, Reveille J, Vilá L, Alarcón G, Study Group L .
Effect of Age, Menopause and Cyclophosphamide Use on Damage Accrual in Systemic Lupus Erythematosus
Patients from LUMINA, a Multiethnic US Cohort. Lupus , 2009; 18(2): 184-186
Danila MI, Pons-Estel GJ, Zhang J , Vilá LM, Reveille JD, Alarcón GS. Renal Damage is the Most Important
Predictor of Mortality within the Damage Index: Data from LUMINA, a Multiethnic US Cohort.
Rheumatology
(Oxford) , 2009; 48(5): 542-5
Pons-Estel GJ, Alarcón GS, McGwin G Jr, Danila MI, Zhang J , Bastian HM, Reveille JD, Vilá LM; Lumina
Study Group. Protective Effect of Hydroxychloroquine on Renal Damage in Patients with Lupus Nephritis: Data from LUMINA, a Multiethnic U.S. Cohort.
Arthritis & Rheumatism (Arthritis Care & Research) , 2009; 6(6): 830-9
Pons-Estel GJ, González LA, Zhang J , Burgos PI, Reveille JD, Vilá LM, Alarcón GS. Predictors of
Cardiovascular Damage in Patients in Systemic Lupus Erythematosus: Data from LUMINA, a Multiethnic US
Cohort.
Rheumatology (Oxford) , 2009; 48(7): 817-22
González L, Pons-Estel G, Zhang J , Vilá L, Reveille J, Alarcón G; for the LUMINA study group. Time to
Neuropsychiatric Damage Occurrence in LUMINA: A Multiethnic Lupus Cohort. Lupus, 2009;18(9):822-830
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Program Director/Principal Investigator (Last, First, Middle)
: Zhang, Jie
Zhang J , McGwin G Jr. Association of statin use with the risk of developing diabetic retinopathy. Archives of
Ophthalmology , 2007; 125(8): 1096-9.
Durán S, Apte M, Alarcón GS, Marion MC, Edberg JC, Kimberly RP,
Zhang J , Langefeld CD,
Vilá LM, Reveille
JD; Lumina Study Group. Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort. Arthritis Rheum , 2008; 59(9):1332-40
D. Research Support
Ongoing
R01HS018517 (Curtis) 07/12 –
Agency for Healthcare Research and Quality (AHRQ)
Longitudinal Comparative Effectiveness & Safety of Biologics in Autoimmunity
The purpose of this project is to gain improved understanding of comparative effectiveness by evaluating clinical data from a prospective cohort study and through an analysis of national Medicare data from 2006-11.
Cardiovascular Diseases in Patients with Rheumatoid Arthritis (Curtis) 07/12 –
Genentech, Inc.
This study will examine the relative contributions of seropositivity, CRP, and hyperlipidemia on cardiovascular risk in RA populations, and examine the effect of pharmacologic treatments on CV risk.
Completed
T32 HS019463-01 (Saag) 07/10 –
Agency for Healthcare Research and Quality (AHRQ)
UAB T32 in Comparative Effectiveness Research
The goal of this project is to build upon the momentum of our ongoing Comparative Effectiveness Research
(CER) and training and to expand our training capacity and vibrant intellectual milieu for CER at UAB.
Validation of Claims-based Algorithms (Delzell) 11/10 – 03/11
Amgen, Inc.
The goals of the project were to built to claims-based algorithm to identify incident vertebral fractures and fractures associated with excessive level of trauma.
Osteoporosis and Related Fracture among Older Americans (Delzell) 06/10 – 12/12
Amgen, Inc.
The study evaluates the health and economic burdens of osteoporosis and related fractures, as well as utilization, effectiveness, and safety of osteoporosis medications, among older Americans, using data on
Medicare and Medicaid beneficiaries from CMS.
PHS 398/2590 (Rev. 06/09) Page 3 Continuation Format Page