PALMER W. TAYLOR, Curriculum Vitae
University of California, San Diego, Department of Pharmacology, 9500 Gilman Drive, La Jolla, CA
92093-0636 (858) 534-1366, Fax: (858) 534-8248, E-mail: pwtaylor@ucsd.edu
Personal Data:
Born October 3, 1938
Married Susan Serota Taylor, three children
Education:
B. S., University of Wisconsin, 1960 - Pharmacy
Ph.D., University of Wisconsin, 1964 - Physical Pharmacy
Honors:
High Honors - University of Wisconsin
Rennebohm Award in Teaching
Rho Chi
Phi Kappa Phi
Phi Eta Sigma
Borden Award
Phi Lambda Upsilon Award in Pharmaceutical Chemistry
Kaiser Permanente Award for Basic Science Teaching - UCSD School of Medicine, 1975,
1977, 1980, 1983, 1984
Professional Experience:
Research Associate, Pharmacology-Toxicology Associate Program, Laboratory of Chemical Pharmacology,
1965-1968, Supervisor: E.O. Titus
NIH Fellowship - Medical Research Council, Molecular Pharmacology Unit, Cambridge, England, 1968-1970
Supervisor: A.S.V. Burgen, FRS, CBE
Continuation of NIH Fellowship, Max Planck Institut fur Physikalsche Chemie, Gottingen, Germany, 1970
Supervisors: Professors M. Eigen and E. Grell
Assistant Professor, Division of Pharmacology, Department of Medicine, UCSD, 1971-1974
Associate Professor, Division of Pharmacology, Department of Medicine, University of California, San Diego,
1974-1978
Professor, Division of Pharmacology, Department of Medicine, UCSD 1978-87
Head, Division of Pharmacology, Department of Medicine, University of California, San Diego, 1979-1987
Professor and Chairman, Department of Pharmacology, 1987-2003
Sandra & Monroe Trout Endowed Chair in Pharmacology, 1994 – present
Dean, Skaggs School of Pharmacy and Pharmaceutical Sciences, 2002 – present
Associate Vice Chancellor for Health Sciences, 2002 – present
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Member, NIH Pharmacology Study Section, 1974-1978
Member, Multiple Sclerosis Society Study Section on Chemotherapeutic Agents, 1974-1986
Co-Chairman, NIH-NIGMS Conference on Membrane Receptors and Diseases, Bethesda, Maryland, 1978
Invited Participant U.S.-Peoples Republic of China - National Academy of Sciences Pharmacology Symposium,
1979
Co-Chair, ASPET Symposium on Application of Molecular Pharmacology to Therapeutic Considerations: A
Bridge between the Molecule and Man; April, 1980
Member, Pharmacological Sciences Review Committee, National Institutes of Health, 1980-1985.
Visiting Fellow, Darwin College, University of Cambridge, 1980-1981
Fogarty Fellow, University of Cambridge, 1980-1981
Sterling Drug Company Visiting Professor, University of Michigan, 1985
Board of Publications Trustees, American Society for Pharmacology and Experimental Therapeutics, 19821985; 1985-1988
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Councillor, American Society for Pharmacology & Experimental Therapeutics, 1987-1990
National Advisory Council, National Institutes of General Medical Sciences, 1988-1992
Advisory Committee to the Director of NIH, NIGMS Representative, 1990-1991
Vice Chair and Chair, Gordon Conference on Molecular Pharmacology, 1987 and 1989
Chair, ASPET Graduate Student Convocation, Montreal, 1988
Krantz Memorial Lecturer, University of Maryland, 1989
Sterling Drug Visiting Professor, University of Oregon, 1990
Congressional Task Force Member on Environmental Health Sciences, 1991
Harold C. Hodge Lecturer, University of Rochester Medical Center, 1992
Plenary Speaker, 33rd Oholo Conference, Israel, 1992
President Elect, American Society for Pharmacology & Experimental Therapeutics, 1994-1995
President, American Society for Pharmacology & Experimental Therapeutics, 1995-1996
Honorary Member, American Society for Clinical Investigation, 1996-Present
Federation of Experimental Biologists (FASEB) Board, 1995-1999
FASEB Industrial Academic Liaison, 1995-1997
FASEB Executive Committee, 1996-1997
Delegate, International Union of Pharmacology, 1995 - 1999
Pharmacological Sciences Review Committee, Burroughs/Wellcome Fund, 1995-2001, (Chair, 1997-1999)
FASEB Public Affairs Executive Committee, 1998- 2000
Delegate, Council of Academic Societies, American Association of Medical Colleges, 1998
Elected, Institute of Medicine, National Academy of Sciences, 1998
NIGMS Merit Award, 1999-2009
Board of Trustees, Gordon Research Conferences, 2000-present
Visiting Professor and Lecturer, College de France, 6/99 - 7/99
Tyler Lecture Series, Purdue University, 11/99
NINDS SNRP Program Advisory Board, 2000-present
FASEB Finance Committee, 2000-present
Elected to Honorary Membership, Croatian-Slovenian Biochemical Society, 2001
Rene Couteaux Lecture – XI International Symposium on Cholinergic Mechanisms, 2002
Torald Sollmann Award in Pharmacology, 2003
Perugia University 700 Year Award for Research in the Cholinesterases, Perugia, Italy, 2004
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Associate Editor, Molecular Pharmacology, 1971-1975; 2000 – present
Co-editor with W.B. Pratt. Principles of Drug Action, 3rd Edition, 1990
Co-editor with A.G. Gilman, T.W. Rall and A.S. Nies. Goodman and Gilman's Pharmacological Basis
of Therapeutics, 8th Edition, 1990
Co-editor with G.V.R. Born, P. Cuatrecasas, D. Ganten, K. Starke Handbook of Experimental Pharmacology –
1998-2003
Editorial Board, Journal of Biological Chemistry, 1981-1986; 1992-1998
Editorial Board, Molecular Pharmacology, 1983-present
Editorial Board, Trends in Pharmacological Sciences, 1983-1990
Consulting Editor, Journal of Clinical Investigation, 1992-1998
Editorial Board, Journal of Molecular Medicine, 1995-present
Editorial Board, Pharmaceutical News, 1997-2004
Founding Editorial Executive Committee, Molecular Interventions, 2000-2005
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American Society for Pharmacology and Experimental Therapeutics
American Society for Biochemistry and Molecular Biology
AAMPS, American Association for Medical School Pharmacology
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BIBLIOGRAPHY
Original Contributions
1.
Wurster, D.E. and Taylor, P.W. Dissolution Rates. J. Pharm. Sci. 54:169-175 (1965).
2.
Wurster, D.E. and Taylor, P.W. Dissolution Kinetics of Certain Crystalline Forms of Prednisolone I. J.
Pharm. Sci. 54:670-676 (1965).
3.
Taylor, P.W. and Wurster, D.E. Dissolution Kinetics of Certain Crystalline Forms of Prednisolone II.
J. Pharm. Sci. 54:1654-1658 (1965).
4.
Sjoqvist, F., Titus, E., Michaelson, I.A., Taylor, P.W. and Richardson, K.C. Uptake and Metabolism of
d, 1-Norepinephrine-7H3 in Tissues of Immunosympathectomized Mice and Rats. Life Sci. 4:11251133 (1965).
5.
Taylor, P.W., Chidsey, C.A., Richardson, K.C., Cooper, T. and Michaelson, I.A. Subcellular
Distribution of Norepinephrine in the Normal and Surgically Denervated Cat Heart. Biochem. Pharm.
15:681 (1966).
6.
Sjoqvist, F., Taylor, P.W. and Titus, E. The Effect of Immunosympathectomy on the Retention and
Metabolism of Noradrenaline. Acta Physiol. Scand. 69:13-22 (1967).
7.
Taylor, P.W., Richardson, K.C., Roddy, P.M. and Titus, E. A New Effect of Reserpine: Accumulation
of Glycoprotein in the Submaxillary Gland. J. Pharmacol. 156:483-491 (1967).
8.
Michaelson, I.A., Taylor, P.W. and Titus, E. Uptake and Metabolism of dI-Norepinephrine by
Subcellular Particles of Rat Heart. J. Pharmacol. 160:277-291 (1968).
9.
Taylor, P.W., King, R.W. and Burgen, A.S.V. Kinetics of Complex Formation between Human
Carbonic Anhydrase and Aromatic Sulfonamides. Biochemistry 9:2638-2645 (1970).
10.
Taylor, P.W., King, R.W. and Burgen, A.S.V. The Influence of pH on the Kinetics of Complex
Formation between Aromatic Sulfonamides and Human Carbonic Anhydrase. Biochemistry 9:38943902 (1970).
11.
Taylor, P.W. and Burgen, A.S.V. Kinetics of Carbonic Anhydrase-Inhibitor Complex Formation. A
Comparison of Anion- and Sulfonamide-Binding Mechanisms. Biochemistry 10:3859-3866 (1971).
12.
Taylor, P.W., Feeney, J.F. and Burgen, A.S.V. Investigation of the Mechanism of Ligand Binding with
Cobalt (II) Human Carbonic Anhydrase by 1H and 19F Nuclear Magnetic Resonance Spectroscopy.
Biochemistry 10:3866-3875 (1971).
13.
Taylor, P.W., Jones, J.W. and Jacobs, N.M. Acetylcholinesterase from Torpedo: Characterization on an
Enzyme Species Isolated by Lytic Procedures. Mol. Pharmacol, 10:78-92 (1974).
14.
Taylor, P.W., Jacobs, N.M. Interaction Between Bis-Quaternary Ammonium Ligands and
Acetylcholinesterase - Complex Formation Studies by Fluorescence Quenching. Mol. Pharmacol.
10:93-108 (1974).
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15.
Taylor, P., Rademacher, J., Lwebuga-Mukasa, J., and Lappi, S. Propidium - A Fluorescence Probe for
a Peripheral Anionic Site on Acetylcholinesterase. Mol. Pharmacol. 10:703-708 (1974).
16.
Taylor, P. and Lappi, S. Interaction of Fluorescence Probes with Acetylcholinesterase; The Site and
Specificity of Propidium Binding. Biochemistry 14:1989-1997 (1975).
17.
Flanagan, S., Taylor, P. and Barondes, S. Affinity Partitioning of Acetylcholine Receptor Enriched
Membranes and Their Purification. Nature (London), 254:441-443 (1975).
18.
Flanagan, S., Barondes, S. and Taylor, P. Affinity Partitioning of Membranes: Cholinergic Receptor
Containing Membranes from Torpedo californica. J. Biol. Chem. 251:858-865 (1976).
19.
Lwebuga-Mukasa, J., Lappi, S. and Taylor, P. Molecular Forms of Acetylcholinesterase from Torpedo
californica: Their Relationship to Synaptic Membranes. Biochemistry 15:1425-1434 (1976).
20.
Lwebuga-Mukasa, J., Harper, E. and Taylor, P. Collagenase Enzymes from Clostridium: Characterization of Individual Enzymes. Biochemistry 15:4736-4741 (1976).
21.
Wee, V.T., Sinha, B.K., Taylor, P. and Chignell, C.F. Interaction of Spin-Labeled Bisquaternary
Ammonium Ligands with Acetylcholinesterase. Mol. Pharmacol. 12:667-677 (1976).
22.
Weiland, G., Georgia, B., Wee, V., Chignell, C.F. and Taylor, P. Ligand Interactions with Cholinergic
Receptor Enriched Membranes from Torpedo: Influence of Agonist Exposure on Receptor Properties.
Mol. Pharmacol. 12:1091-1105 (1976).
23.
Weiland, G., Georgia, B., Lappi, S., Chignell, C.F. and Taylor, P. Kinetics of Agonist Mediated
Transitions in State of the Cholinergic Receptor. J. Biol. Chem. 252:7648-7656 (1977).
24.
Berman, H.A. and Taylor, P. A Fluorescent Phosphonate Label for Serine Hydrolases, Pyrenebutyl
Methylphosphonofluoridate: Reaction with Acetylcholinesterase. Biochemistry 17:1704-1713 (1978).
25.
Weiland, G. and Taylor, P. Ligand Specificity of State Transitions in the Cholinergic Receptor:
Behavior of Agonists and Antagonists. Mol. Pharmacol. 15:197-212 (1979).
26.
Weiland, G., Frisman, D. and Taylor, P. Affinity Labeling of the Subunits of the Membrane Associated
Cholinergic Receptor. Mol. Pharmacol., 15:213-226 (1979).
27.
Sine, S.M. and Taylor, P. Functional Consequences of Agonist-mediated State Transitions in the
Cholinergic Receptor. J. Biol. Chem. 254:3315-3325 (1979).
28.
Bolger, M.B. and Taylor, P. Kinetics of Association Between Bisquaternary Ammonium Ligands and
Acetylcholinesterase. Evidence for Two Conformational States of the Enzymes from Stopped-Flow
Measurements of Fluorescence. Biochemistry 18:3622-3629 (1979).
29.
Epstein, D., Berman, H.A. and Taylor, P. Ligand-Induced Conformational Changes in
Acetylcholinesterase Investigated With Fluorescent Phosphonates. Biochemistry 18:4749-4754 (1979).
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30.
Berman, H.A., Yguerabide, J. and Taylor, P. Fluorescence Energy Transfer on Acetylcholinesterase:
Spatial Relationship between Peripheral Site and Active Center. Biochemistry 19:2226-2235 (1980).
31.
Sine, S.M. and Taylor, P. The Relationship between Agonist Occupation and the Permeability
Response of the Cholinergic Receptor Revealed by Bound Cobra -Toxin. J. Biol. Chem. 255:1014410156 (1980).
32.
Sine, S.M. and Taylor, P. Relationship between Reversible Antagonist Occupancy and the Functional
Capacity of the Acetylcholine Receptor. J. Biol. Chem. 256:6692-6699 (1981).
33.
Berman, H.A., Becktel, W. and Taylor, P. Spectroscopic Studies on Acetylcholinesterase: Influence of
Peripheral Site Occupation on Active Center Conformation. Biochemistry 20:4803-4810 (1981).
34.
Johnson, D.A. and Taylor, P. Site-Specific Fluorescein-Labeled Cobra -Toxin Biochemical and
Spectroscopic Characterization. J. Biol. Chem. 257:5632-5639 (1982).
35.
Sine, S.M. and Taylor, P. Local Anesthetics and Histrionicotoxin are Allosteric Inhibitors of the
Acetylcholine. J. Biol. Chem. 257:8106-8114 (1982).
36.
Lee, S.L., Heinemann, S. and Taylor, P. Structure of the Asymmetric Forms of Torpedo
Acetylcholinesterase I. Analysis of Subunit Composition. J. Biol. Chem. 257:12283-12291 (1982).
37.
Lee, S.L. and Taylor, P. Structural Characterization of the Asymmetric (17+13) Species of
Acetylcholinesterase from Torpedo. J. Biol. Chem. 257:12292-12301 (1982).
38.
Lee, S.L., Camp, S.J. and Taylor, P. Characterization of a Hydrophobic, Dimeric Form of
Acetylcholinesterase from Torpedo. J. Biol. Chem. 257:12302-12309 (1982).
39.
Brown, R.D. and Taylor, P. The Influence of Antibiotics on Agonist Occupation and Functional State
of the Nicotinic Acetylcholine Receptor. Mol. Pharmacol. 23:8-16 (1982).
40.
Hughes, R.J., Boyle, M.D., Brown, R.D., Taylor, P. and Insel, P.A. Characterization of Coexisting 1
and ß2-Adrenergic Receptors on a Cloned Muscle Cell Line BC3H-1. Mol. Pharmacol. 22:258-266
(1982).
41.
Doctor, B.P., Camp, S., Gentry, M.K., Taylor, S.S. and Taylor, P. Antigenic and Structural Differences
in the Catalytic Subunits of the Molecular Forms of Acetylcholinesterase. Proc. Natl. Acad. Sci. USA
80:5767-5771 (1983).
42.
Cheung, A., Johnson, D.A. and Taylor, P. Kinetics of Interaction of N-Fluorescein IsothiocyanateLysine-23-Cobra -Toxin with the Acetylcholine Receptor. Biophys. J. 45:447-454 (1984).
43.
Culver, P., Fenical, W. and Taylor, P. Lophotoxin Irreversibly Inactivates the Nicotinic Acetylcholine
Receptor by Preferential Association at One of the Two Primary Agonist Sites. J. Biol. Chem.
259:3763-3770 (1984).
44.
Bolger, M.B., Dionne, V., Chrivia, J., Johnson, D.A. and Taylor, P. Interaction of a Fluorescent
Acyldicholine with the Nicotinic Acetylcholine Receptor and Acetylcholinesterase. Mol. Pharmacol.
26:57-69 (1984).
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45.
Johnson, D.A., Voet, J. and Taylor, P. Fluorescence Energy Transfer between Cobra -Toxin
Molecules Bound to the Acetylcholine Receptor. J. Biol. Chem. 259:5717-5725 (1984).
46.
Brown, R.D., Berger, K. and Taylor, P. Alpha1-adrenergic Receptor Activation Mobilizes Cellular
Calcium in a Muscle Cell Line. J. Biol. Chem. 259: 7554-7562 (1984).
47.
Amitai, G., Brown, R.D. and Taylor, P. The Relationship between Alpha1- adrenergic Receptor
Occupation and the Mobilization of Intracellular Calcium. J. Biol. Chem. 12519-12527 (1984).
48.
Ambler, S.K., Brown, R.D. and Taylor, P. The Relationship Between Phosphatidylinositol Metabolism
and Mobilization of Intercellular Calcium Elicited by 1-Adrenergic Receptor Stimulation in BC3H-1
Muscle Cells. Mol. Pharmacol. 26:405-413 (1984).
49.
Manavalan, P., Taylor, P. and Johnson, W.C. Circular Dichroism Studies of Acetylcholinesterase
Conformation: Comparison of the 11 S and 5.6 S species and the differences induced by inhibitory
ligands. Biochem. Biophys. Acta 829:365-370 (1985).
50.
MacPhee-Quigley, K., Taylor, P. and Taylor, S. Primary Structures of the Catalytic Subunits from Two
Molecular Forms of Acetylcholinesterase: A comparison of NH2-terminal and active center sequences.
J. Biol. Chem. 260:12185-12189 (1985).
51.
Culver, P., Burch, M., Potenza, C., Wasserman, L., Fenical, W. and Taylor, P. Structure-Activity
Relationships for the Irreversible Blockade of Nicotinic Receptor Agonist Sites by Lophotoxin and
Congeneric Diterpene Lactones. Mol. Pharmacol. 28:436-444 (1985).
52.
Berman, H.A., Yguerabide, J. and Taylor, P. Flexibility of the Molecular Forms of Acetylcholinesterase
Measured with Steady State and Time Correlated Fluorescence Polarization. Biochemistry 24:71407147 (1985).
53.
Schumacher, M., Camp, S., Maulet, Y., Newton, M., MacPhee-Quigley, K., Taylor, S.S., Friedmann, T.
and Taylor, P. Primary Structure of Torpedo californica Acetylcholinesterase Deduced from its cDNA
Sequence. Nature 319:407-409 (1986).
54.
Ambler, S.K. and Taylor, P. Mobilization of Intracellular Calcium by 1-Adrenergic Receptor
Activation in Muscle Cell Monolayers. J. Biol. Chem. 261:5866-5871 (1986).
55.
Palma, A., Herz, J., Wang, H. and Taylor, P. Association of a Spin-Labeled Local Anesthetic with the
Allosterically Coupled Noncompetitive Inhibitor Site on the Acetylcholine Receptor. Mol. Pharmacol.
30:243-251 (1986).
56.
MacPhee-Quigley, K., Vedvick, T., Taylor, P. and Taylor, S.
Acetylcholinesterase. J. Biol. Chem. 261:13565-13570 (1986).
57.
Edery, H., Geyer, M., Taylor, P. and Berman, H.A. Target Sites for Anticholinesterases on the Ventral
Surface of the Medulla Oblongata: Hypotension Elicited by Organophosphorus Agents. J. Auton.
Pharmac. 6:195-209 (1986).
58.
Herz, J.M., Johnson, D.A. and Taylor, P.
Profile of Disulfide Bonds on
Interaction of Noncompetitive Inhibitors with the
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Acetylcholine Receptor: The Site Specificty and Spectroscopic Properties of Ethidium Binding. J. Biol.
Chem. 262:7238-7247 (1987).
59.
Berman, M.A., Decker, M.M., Nowak, M.W., Leonard, K.J., McCauley, M., Baker, W.M. and Taylor,
P. Site Selectivity of Fluorescent Bisquaternary Phenanthridium Ligands for Acetylcholinesterase. Mol.
Pharmacol. 31:610-616 (1987).
60.
Ambler, S.K., Thompson, B., Solski, P.A., Brown, J.H. and Taylor, P. Receptor-Mediated Inositol
Phosphate Formation in Relation to Calcium Mobilization: A Comparison of Two Cell Lines. Mol.
Pharmacol. 32:376-383 (1987).
61.
Brown, R.D., Berger, K.D. and Taylor, P. The Relationship Between 1-Adrenergic Receptor
Occupancy and Response in BC3H-1 Muscle Cells. Mol. Pharmacol. 32:43-52 (1987).
62.
Johnson, D.A., Brown, R.D., Andreason, G., Herz, J., Berman, H.A. and Taylor, P. Decidium: A Novel
Fluorescent Probe of the Agonist/Antagonist and Noncompetitive Inhibitor Sites on the Nicotinic
Acetylcholine Receptor. J. Biol. Chem. 262:14022-14029 (1987).
63.
Aslanian, D., Grof, P., Negrerie, M., Balkanski, M. and Taylor, P. Raman Spectroscopic Study on the
Conformation of 11 S Form Acetylcholinesterase from Torpedo Californica. FEBS Letter 219:202-206
(1987).
64.
Gibney, G., Quigley, K.M., Thompson, B., Vedvick, T., Low, M.G., Taylor, S.S. and Taylor, P.
Divergence in Primary Structure Between the Molecular Forms of Acetylcholinesterase. J. Biol. Chem.
263:1140-1145 (1988).
65.
Ambler, S.K., Poenie, M., Tsien, R.Y. and Taylor, P. Agonist-Stimulated Oscillations and Cycling of
Intracellular Free Calcium in Individual Cultured Muscle Cells. J. Biol. Chem. 263:1952-1959 (1988).
66.
Traynor, A.E., Harris, A.L., Thompson, B.L., Taylor, P. and Sklar, L.A. An Inositol Tetrakisphosphatecontaining Phospholipid in Activated Neutrophils. Nature 334:353-356 (1988).
67.
Schumacher, M., Maulet, Y., Camp S. and Taylor, P. Multiple Messenger RNA Species Give Rise to
the Structural Diversity in Acetylcholinesterase. J. Biol. Chem. 263:18979-18987 (1988).
68.
Abramson, S., Culver, P., Li, Y., Kline, T., Gutman, L., Guest, P. and Taylor, P. Lophotoxin and
Related Coral Toxins Covalently Label the -Subunit of the Nicotinic Acetylcholine Receptor. J. Biol.
Chem. 263:18568-18573 (1988).
69.
Ambler, S.K. and Taylor, P. Release of Nonmitochondrial Sequestered Ca2+ from Permeabilized
Muscle Cells in Culture. Mol. Pharmacol. 35:369-374 (1989).
70.
Traynor-Kaplan, A.E., Harris, A.L., Thompson, B.L., Taylor, P. and Sklar, L.A. Transient Increase in
Phosphatidylinositol 3,4-Bisphosphate and Phosphatidylinositol Trisphosphate During Activation of
Human Neutrophils. J. Biol. Chem. 264:15668-15673 (1989).
71.
Abramson, S.N., Ellisman, M.H., Deernick, T.J., Maulet, Y., Gentry, M.K., Doctor, B.P. and Taylor, P.
Differences in Structure and Distribution of the Molecular Forms of Acetylcholinesterase. J. Cell Biol.
108:2301-2311 (1989).
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72.
Abramson, S.N., Li, Y., Culver, P. and Taylor, P. An Analog of Lophotoxin Reacts Covalently with
Tyr190 in the -Subunit of the Nicotinic Acetylcholine Receptor. J. Biol. Chem. 264:12666-12672
(1989).
73.
Abramson, S.N., Radic, Z., Manker, D., Faulkner, D.J. and Taylor, P. Onchidal: A Naturally Occurring
Irreversibe Inhibitor of Acetylcholinesterase with a Novel Mechanism of Action. Mol. Pharmacol.
36:349-354 (1989).
74.
Herz, J., Johnson, D.A. and Taylor, P. Distance Between the Agonist and Non-Competitive Inhibitor
Sites on the Nicotinic Acetylcholine Receptor. J. Biol. Chem. 264:12439-12448 (1989).
75.
Ludgate, M., Dong, Q., Dreyfus, P.A., Zakat, H., Taylor, P., Vassart, G. and Soreq, H. Definition at a
Molecular Level of a Thyroglobulin-Acetylcholinesterase Shared Epitope: Study of the
Pathophysiological Significance in Patients with Graves' Ophthalmopathy. Autoimmunity 3:167-176
(1989).
76.
Fibroulet, A., Reiger, F., Goudou, D., Amitai, G. and Taylor, P. Interaction of an Organophosphate with
a Peripheral Site on Acetylcholinesterase. Biochemistry 29:914-920 (1990).
77.
Maulet, Y., Camp, S., Gibney, G., Rachinsky, T., Ekström, T. and Taylor, P. Single Gene Encodes
Glycophospholipid-Anchored and Asymmetric Acetylcholinesterase Forms: Alternative Coding Exons
Contain Inverted Repeat Sequences. Neuron 4:289-301 (1990).
78.
Gibney, G.G. and Taylor, P. Biosynthesis of Torpedo Acetylcholinesterase in Mammalian Cells.
Functional Expression and Mutagenesis of the Glycophospholipid-Anchored Form. J. Biol. Chem.
265:12576-12583 (1990).
79.
Gibney, G.G., Camp, S., Dionne, M., Quigley, K.-M. and Taylor, P. Mutagenesis of Essential
Functional Residues in Acetylcholinesterase. Proc. Natl. Acad. Sci. (USA) 87:7546-7550 (1990).
80.
Ogert, R.A., Gentry, M.K., Richardson, E.C., Deal, C.D., Abramson, S.N., Alving, C.R., Taylor, P. and
Doctor, B.P. Studies on the Topography of the Catalytic Site of Acetylcholinesterase Using Polyclonal
and Monoclonal Antibodies. J. Neurochem. 55:756-763 (1990).
81.
Rachinsky, T.L., Camp, S., Li, Y., Ekström, T.J., Newton, M. and Taylor, P. Molecular Cloning of
Murine Acetylcholinesterase: Tissue Distribution of Alternatively Spliced mRNA Species. Neuron
5:317-327 (1990).
82.
Radic, Z., Reiner, E. and Taylor, P. Role of the Peripheral Anionic Site on Acetylcholinesterase:
Inhibition by Substrates and Coumarin Derivatives. Mol. Pharm. 39:98-104 (1991).
83.
Abramson, S.N., Trischman, J.A., Tapiolas, D.M., Herold, E.E., Fenical, W. and Taylor, P.
Structure/Activity and Molecular Modeling Studies of the Lophotoxin Family of Irreversible Nicotinic
Receptor Antagonists. J. Med. Chem. 34:1798-1804 (1991).
84.
Li, Y., Camp, S., Rachinsky, T.L., Getman, D. and Taylor, P. Gene Structure of Mammalian
Acetylcholinesterase. Alternative Exons Dictate Tissue Specific Expression. J. Biol. Chem.
266:23083-23090 (1991).
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85.
Aslanian, D., Grof, P., Bon, S., Masson, P., Negrerie, M., Chatel, J.M., Balkanski, M., Taylor, P. and
Massoulié, J. A Comparative Raman Spectroscopic Study of Cholinesterases. Biochimie 73:1375-1386
(1991).
86.
Getman, D., Eubanks, J.H., Camp, S., Evans, G.A. and Taylor, P. The Human Gene Encoding
Acetylcholinesterase is Located on the Long Arm of Chromosome 7. Amer. J. Human Genetics 51:170177 (1992).
87.
Radic, Z., Gibney, G., McPhee-Quigley, K., Kawamoto, S., Bongiorno, C. and Taylor, P. Expression of
Recombinant Acetylcholinesterase in Baculovirus Systems: Kinetic Properties of Glutamate 199
mutants. Biochemistry 31:9760-9767 (1992).
88.
Rachinsky, T., Crenshaw III, E.B. and Taylor, P. Assignment of the Gene for Acetylcholinesterase to
Distal Mouse Chromosome 5. Genomics 14:511-514 (1992).
89.
Ekström, T.J., Klump, W., Getman, D., Karin, M. and Taylor, P. Promoter Elements and
Transcriptional Regulation of the Acetylcholinesterase Gene. DNA and Cell Biol. 12:63-72 (1993).
90.
Li, Y., Camp, S., Rachinsky, T., Bongiorno, C. and Taylor, P. Promoter Elements and Transcriptional
Control of the Mouse Acetylcholinesterase Gene. J. Biol. Chem. 268:3563-3572 (1993).
91.
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92.
Li, Y., Camp, S., and Taylor, P. Tissue Specific Expression and Alternative mRNA Processing of the
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93.
Hutchinson, D.V., Walls, T.J., Nakano, S., Camp, S., Taylor, P., Harper, C.B., Groover, V., Peterson,
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94.
Fuentes, M.E. and Taylor, P. Control of Acetylcholinesterase Gene Expression During Myogenesis.
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95.
Wasserman, L., Doctor, B.P., Gentry, M.K. and Taylor, P. Epitope Mapping of Form-Specific and
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96.
Radic, Z., Pickering, N., Vellom, D.C., Camp, S. and Taylor, P. Three Distinct Domains in the
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97.
Saxena, A., Doctor, B.P., Maxwell, D.M., Lenz, D.E., Radic, Z. and Taylor, P. The Role of Glutamate
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98.
Rothman, A., Wolner, B., Button, D. and Taylor, P. Immediate-early Gene Expression in Response to
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99.
Khan, I.M., Taylor, P. and Yaksh, T.L. Cardiovascular and Behavioral Responses to Nicotinic Agents
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100. Khan, I.M., Yaksh, T.L. and Taylor, P. Ligand Specificity of Nicotinic Acetylcholine Receptors in Rat
Spinal Cord: Studies with Nicotine and Cytisine. J. Pharmacol. Exp. Ther. 270:159-166 (1994).
101. Radic, Z., Duran, R., Vellom, D.C., Li, Y., Cervenansky, C. and Taylor, P. Site of Fasciculin Interaction
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102. Button, D., Rothman, A., Bongiorno, C., Kupperman, E., Wolner, B. and Taylor, P. Agonist-selective
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103. Kreienkamp, H.-J., Sine, S.M., Maeda, R.K. and Taylor, P. Glycosylation Sites Selectively Interfere with
-Toxin Binding to the Nicotinic Acetylcholine Receptor. J. Biol. Chem. 269:8108-8114 (1994).
104. Sine, S.M., Quiram, P., Papanikolaou, F., Kreienkamp, H-J. and Taylor, P. Conserved Tyrosines in the
Alpha Subunit of the Nicotinic Acetylcholine Receptor Stabilize Quaternary Ammonium Groups of
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105. Saxena, A., Qian, N., Kovach, I.M., Kozikozoski, A.P., Pang, Y.P., Vellom, D.C., Radic, Z., Quinn, D.,
Taylor, P. and Doctor, B.P. Identification of Amino Acid Residues Involved in the Binding of HuperzineA to Cholinesterases. Protein Science 3:1770-1778 (1994).
106. Khan, I.M., Printz, M.P., Yaksh, T.L. and Taylor, P. Augmented Responses to Intrathecal Nicotinic
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107.
Khan, I.M., Taylor, P. and Yaksh, T.L. Stimulatory Pathways and Sites of Action of Intrathecally
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108.
Luo, Z., Fuentes, M.E. and Taylor, P. Regulation of Acetylcholinesterase mRNA Stability by Calcium
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109.
Camp, S., Bon, S., Li, Y., Getman, D.K., Engel, A.G., Massouliè, J. and Taylor, P. Patients with
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110.
Mutero, A., Camp, S. and Taylor, P. Promoter Elements of the Mouse Acetylcholinesterase Gene:
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111.
Keller, S.H., Kreienkamp, H.-J., Kawanishi, C. and Taylor, P. Molecular Determinants Conferring Toxin Resistance in Recombinant-DNA Derived Acetylcholine Receptors. J. Biol. Chem. 270:41654171 (1995).
112.
Kreienkamp. H.-J., Maeda, R.K., Sine, S.M. and Taylor, P. Intersubunit Contacts Governing Assembly
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113.
Ashani, Y., Radic, Z., Tsigelny, I., Vellom, D.C., Pickering, N.A., Quinn, D.M., Doctor, B.P. and
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Acetylcholinesterase by Mono- and Bisquaternary Oximes. J. Biol. Chem. 270:6370-6380 (1995).
114.
Van den Born, H.K.L., Radic, Z., Marchot, P., Taylor, P. and Tsigelny, I. Theoretical Analysis of the
Structure of the Peptide Fasciculin and its Docking to Acetylcholinesterase. Protein Science 4:703-715
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115.
Radic, Z., Quinn, D.M., Vellom, D.C., Camp, S. and Taylor, P.
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116.
Sine, S.M., Kreienkamp, H.-J., Bren, N., Maeda, R.M. and Taylor, P. Molecular Dissection of Subunit
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117.
Getman, D.K., Mutero, A., Inoue, K. and Taylor, P. Transcription Factor Repression and Activation of
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118.
Hosea, N.A., Berman, H.A. and Taylor, P. Specificity and Orientation of Trigonal Carboxyl Esters and
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119.
Bourne, Y., Taylor, P. and Marchot, P. Acetylcholinesterase Inhibition by Fasciculin: Crystal Structure
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120.
Taylor, P., Radic, Z., Hosea, N.A., Camp, S., Marchot, P. and Berman, H.A. Structural bases for the
specificity of cholinesterase catalysis and inhibition. Tolicology Letters 82/83:453-458 (1995).
121.
Coleman, B.A. and Taylor, P. Regulation of Acetylcholinesterase Expression During Neuronal
Differentiation. J. Biol. Chem. 271:4410-4416 (1996).
122.
Marchot, P., Ravelli, R.B.G., Raves, M.L., Bourne, Y., Vellom, D.C., Kanter, J., Camp, S., Sussman,
J.L. and Taylor, P. Soluble Monomeric Acetylcholinesterase from Mouse: Expression, Purification, and
Crystallization in Complex with Fasciculin. Protein Science 5:672-679 (1996).
123.
Luo, Z.D., Pincon-Raymond, M. and Taylor, P. Acetylcholinesterase and Nicotinic Acetylcholine
Receptor Expression Diverge in Muscular Dysgenic Mice Lacking the L-type Calcium Channel. J.
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124.
Khan, I.M., Marsala, M., Printz, M.P., Taylor, P. and Yaksh, T.L. Intrathecal Nicotinic Agonist-Elicited
Release of Excitatory Amino Acids as Measured by in vivo Spinal Microdialysis in Rats. J. Pharmacol.
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125.
Hosea, N.A., Radic, Z., Tsigelny, I., Berman, H.A., Quinn, D.M. and Taylor, P. Aspartate 74 as a
Primary Determinant in Acetylcholinesterase Governing Specificity to Cationic Organophosphates.
Biochemistry 35:10995-11004 (1996).
126.
Keller, S.H., Lindstrom, J. and Taylor, P. Involvement of the Chaperone Protein Calnexin and the
Acetylcholine Receptor -Subunit In the Assembly and Cell Surface Expression of the Receptor. J.
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127.
Sugiyama, N., Boyd, A.E. and Taylor, P.
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Acetylcholine Receptor Contributing to Subunit Assembly and Ligand Binding.
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Khan, I.M., Youngblood, K.L., Printz, M.P., Yaksh, T.L. and Taylor, P. Spinal Nicotinic Receptor
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129.
Marchot, P., Prowse, C.N., Kanter, J. Camp, S., Ackermann, E., Radic, Z., Bougis, P.E. and Taylor, P.
Expression and Activity of Mutants of Fasciculin, a Peptidic Acetylcholinesterase Inhibitor from
Mamba Venom. J. Biol. Chem., 272:3502-3510 (1997).
130.
Khan, I.M., Yaksh, T.L. and Taylor, P. Epibatidine Binding Sites and Activity in the Spinal Cord.
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131.
Tsigelny, I., Sugiyama, N., Sine, S.M. and Taylor, P. A Model of the Nicotinic Receptor Extracellular
Domain Based on Sequence Identity and Residue Location. Biophys. J., 73:52-66 (1997).
132.
Saxena, A., Maxwell, D., Quinn, D.M., Radic, Z. Taylor, P. and Doctor, B.P. Mutant
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133.
Radic, Z., Kirchhoff, P., Quinn, D.M., McCammon, J.A. and Taylor, P. Electrostatic Influence on the
Kinetics of Ligand Binding to Acetylcholinesterase: Distinctions Between Active Center Ligands and
Fasciculin. J. Biol. Chem., 272:23265-23277 (1997).
134.
Ackermann, E.J. and Taylor, P. Non-Identity of the -Neurotoxin Binding Sites on the Nicotinic
Acetylcholine Receptor Revealed by Modification of the -Neurotoxin and Receptor Structures.
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135.
Sugiyama, N., Marchot, P., Kawanishi, C., Osaka, H., Molles, B., Sine, S.M., and Taylor, P. Residues
at the Subunit Interfaces of the Nicotinic Acetylcholine Receptor that Contribute to -Conotoxin M1
Binding. Mol. Pharmacol., 53:787-794 (1998).
136.
Ackermann, E.J., Ang, E.T.H., Kanter, J., Tsigelny, I. and Taylor, P. Identification of Pairwise
Interactions in the -Neurotoxin-Nicotinic Acetylcholine Receptor Complex Through Double Mutant
Cycles. J. Biol. Chem., 273:10958-10964 (1998).
137.
Osaka, H., Sugiyama, H., and Taylor, P. Distinctions in Agonist and Antagonist Specificity Conferred
by Anionic Residues of the Nicotinic Acetylcholine Receptor. J. Biol. Chem., 273:12758-12765 (1998).
138.
Keller, S., Lindstrom, J.M. and Taylor, P. Inhibition of Glucose Trimming with Castanospermine
Reduces Calnexin Association and Promotes Proteasome Degradation of the -Subunit of the Nicotinic
Acetylcholine Receptor. J. Biol. Chem., 273:17064-17072 (1998).
139.
Tara, S., Elcock, A.H., Kirchhoff, P.D., Briggs, J.M., Radic, Z., Taylor, P. and McCammon, J.A. Rapid
Binding of a Cationic Active Site Inhibitor to Wild Type and Mutant Mouse Acetylcholinesterase:
Brownian Dynamics Simulation Including Diffusion in the Active Site Gorge. Biopolymers, 46:465474 (1998).
140.
Luo, Z..D., Camp, S., Mutero, A. and Taylor, P. Splicing of 5-Introns Dictates Alternative Splice
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Selection of Acetylcholinesterase Pre-mRNA and Specific Expression During Myogenesis. J. Biol.
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141.
Khan, I.M., Buerkle, H., Taylor, P. and Yaksh, T.L. Nociceptive and antinociceptive responses to
intrathecally administered nicotinic agonists. Neuropharmacology, 37:1515-1525 (1998).
142.
Bourne, Y., Taylor, P., Bougis, P.E. and Marchot, P. Crystal Structure of Mouse Acetylcholinesterase:
A Peripheral Site-Occluding Loop in a Tetrameric Assembly. J. Biol. Chem., 274:2963-2970 (1999).
143.
Osaka, H., Malany, S., Kanter, J.R., Sine, S.M. and Taylor, P. Subunit Interface Selectivity of the Neurotoxins for the Nicotinic Acetylcholine Receptor. J. Biol. Chem., 274:9581-9586 (1999).
144.
Luo, C., Saxena, A., Smith, M., Garcia, G., Radic, Z., Taylor, P. and Doctor, B.P. Phosphoryl Oxime
Inhibition of Acetylcholinesterase during Oxime Reactivation Is Prevented by Edrophonium.
Biochemistry, 38:9937-9947 (1999).
145.
Luo, Z.D., Wang, Y., Werlen, G., Camp, S., Chien, K.R. and Taylor, P. Calcineurin Enhances
Acetylcholinesterase mRNA Stability During C2-C12 Muscle Cell Differentiation. Mol. Pharmacol.,
56:886-894 (1999).
146.
Tsigelny, I., Shindyalov, I.N., Bourne, P.E., Sudhof, T.C. and Taylor, P. Common EF-Hand Motifs in
Cholinesterases and Neuroligins Suggest a Role for Ca2+ Binding in Cell Surface Associations. Protein
Sci., 9:180-185 (2000).
147.
Osaka, H., Malany, S., Molles, B.E., Sine, S.M. and Taylor, P. Pairwise Electrostatic Interactions
Between -neurotoxins and , , and  Subunits of the Nicotinic Acetylcholine Receptor. J. Biol.
Chem., 275:5478-5484 (2000).
148.
Wong, L., Radic, Z., Bruggeman, R.J.M., Hosea, N., Berman, H.A. and Taylor, P. Mechanism of
Oxime Reactivation of Acetylcholinesterase Analyzed by Chirality and Mutagenesis. Biochemistry, 39:
5750-5757 (2000).
149.
Boyd, A.E., Marnett, A.B., Wong, L. and Taylor, P. Probing the Active Center Gorge on
Acetylcholinesterase by Fluorophores Linked to Substituted Cysteines. J. Biol. Chem., 275:2240122408 (2000).
150.
Xie, W., Stribley, J.A., Chatonnet, A., Wilder, P.J., Rizzino, A., McComb, R.D., Taylor, P., Hinrichs,
S.H. and Lockridge, O. Postnatal Developmental Delay and supersensitivity to organophosphate in
gene-targeted mice lacking acetylcholinesterase. J. Pharmacol. Exp. Ther., 293:896-902 (2000).
151.
Malany, S., Sawai, M., Sikorski, R.S., Seravalli, J., Quinn, D., Radic, Z., Taylor, P., Kronman, C.,
Velan, B., and Shafferman, A. Transition State Structure and Rate Determination for the Acylation
Stage of Acetylcholinesterase Catalyzed Hydrolysis of (Acetylthio)choline. J. Am. Chem. Soc.,
122:2981-2987 (2000).
152.
Quinn, D.M., Feaster, S.R., Nair, H.K., Baker, N.A., Radic', Z and Taylor, P. Delineation and
Decomposition of Energies Involved in Quaternary Ammonium Binding in the Active Site of
Acetylcholinesterase. J. Amer. Chem. Soc., 122:2975-2980 (2000).
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153.
Kraut, D., Goff, H., Pai, R.K., Hosea, N.A., Silman, I., Sussman, J., Taylor, P., and Voet, J. Inactivation
Studies of Acetylcholinesterase with Phenylmethylsulfonyl Fluoride. Mol. Pharm., 57: 1243-1248
(2000).
154.
Malany, S., Osaka, H., Sine, S.M. and Taylor, P. Orientation of -Neurotoxin at the Subunit Interfaces
of the Nicotinic Acetylcholine Receptor. Biochemistry, 39:15388-15398 (2000).
155.
Saltmarsh, J.R., Boyd, A.E., Rodriguez, O.P., Radic, Z., Taylor, P. and Thompson, C.M. Synthesis of
Fluorescent Probes Directed to the Active Site Gorge of Acetylcholinesterase. Bioorganic and
Medicinal Chemistry Letters, N14:1523-1626 (2000).
156.
Radic, Z. and Taylor, P. Interaction Kinetics of Reversible Inhibitors and Substrates with
Acetylcholinesterase and Its Fasciculin 2 Complex. J. Biol. Chem., 276:4622-4633 (2001).
157.
Keller, S.H., Lindstrom, J., Ellisman, M. and Taylor, P. Adjacent Basic Amino Acid Residues
Recognized by the COP1 Complex and Ubiquitination Govern Endoplasmic Reticulum to Cell
Surface Trafficking of the Nicotinic Acetylcholine Receptor Alpha Subunit. J. Biol. Chem., 276:
18384-18391 (2001).
158.
Khan, I.M., Stanislaus, S., Zhang, L., Taylor, P. and Yaksh, T. A-85830 and Epibatidine Each Interact
with Disparate Spinal Nicotinic Receptor Subtypes to Achieve Analgesia and Nociception. J.
Pharmacol. Exp. Ther., 297:230-239 (2001).
159.
Shi, J., Boyd, A.E., Radic, Z. and Taylor, P. Reversibly Bound and Covalently Attached Ligands Induce
Conformational Changes in the Omega Loop, Cys 69-Cys96, of Mouse Acetylcholinesterase. J. Biol.
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160.
Khan, I.M., Stanislaus, S., Zhang, L., Vaughn, D., Printz, M.P., Yaksh, T.L. and Taylor, P. Spinal
Nicotinic Receptor Activity in a Genetic Model of Hypertension. Clin. Exper. Hyper., 23:555-568
(2001).
161.
Molles, B.E., Rezai, P., Kline, E., McArdle, J., Sine, S.M. and Taylor, P. Identification of Residues at
the α and ε Subunit Interfaces Mediating Species Selectivity of Waglerin-1 for Nicotinic Acetylcholine
Receptors. J. Biol. Chem., 277:5433-5440 (2002).
162.
Lewis, W.G., Green, L.G., Grynszpan, F., Radic, Z., Carlier, P.R., Taylor, P., Finn, M.G. and Sharpless,
K.B. Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of
a Femtomolar Inhibitor from an Array of Building Blocks. Angew. Chem., 41:1053-1057 (2002).
163.
Molles, B.E., Tsigelny, I., Nguyen, P.D., Gao, S.X., Sine, S.M. and Taylor, P. Residues in the  Subunit
of the Nicotinic Acetylcholine Receptor Interact to Confer Selectivity of Waglerin 1 for the - Subunit
Interface Site. Biochemistry, 41:7895-7906 (2002).
164.
Shi, J., Radic, Z. and Taylor, P. Inhibitors of Different Structure Induce Distinguishing Conformations
in the Omega Loop, Cys 69-Cys 96, of Mouse Acetylcholinesterase. J. Biol. Chem. 277:43301-43308
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165.
Khan, I.M., Singletary, E., Alemayehu, A., Stanislaus, S., Printz, M.P., Yaksh, T.L. and Taylor, P.
Nicotinic Receptor Gene Cluster on Rat Chromosome 8 in Nociceptive and Blood Pressure
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Hyperresponsiveness. Physiological Genomics, 11:65-72 (2002).
166.
Hansen, S.B., Radic, Z., Talley, T.T., Molles, B.E., Deernick, T., Tsigelny, I. and Taylor, P. Tryptophan
Fluorescence Reveals Conformational Changes in the Acetylcholine Binding Protein. J. Biol. Chem.
277:41299-41302 (2002).
167.
Bourne, Y., Taylor, P., Radic, Z. and Marchot, P. Structural Insights into Ligand Interactions at the
Acetylcholinesterase Peripheral Anionic Site. The EMBO J., 22:1-12 (2003).
168.
Gao, F., Bren, N., Little, A., Wang, H-L, Hansen, S.B., Talley, T.T., Taylor, P., and Sine, S.M.
Curariform Antagonists Bind in Different Orientations to Acetylcholine-binding Protein. J. Biol.
Chem., 278:23020-23026 (2003).
169.
Shi, J., Tai, K., McCammon, J.A., Taylor, P. and Johnson, D.A. Nanosecond Dynamics of the
Mouse Acetylcholinesterase Cys69-Cys96 Omega Loop. J. Biol. Chem., 278:30905-30911 (2003).
170.
Kovarik, Z., Radic, Z., Berman, H.A., Simeon-Rudolf, V., Reiner, E. and Taylor, P.
Acetylcholinesterase Active Centre and Gorge Conformations Analysed by Combinatorial Mutations
and Enantiomeric Phosphonates. Biochem. J., 373:33-40 (2003).
171.
Luo, C., Leader, H., Radic Z., Maxwell, D.M., Taylor, P., Doctor, B.P. and Saxena, A. Two Possible
Orientations of the HI-6 Molecule in the Reactivation of Organophosphate-Inhibited
Acetylcholinesterase. Biochem. Pharmacol., 66:387-392 (2003).
172.
Jennings, L.L., Malecki, M., Komives, E.A. and Taylor, P. Direct Analysis of the Kinetic Profiles of
Organophosphate-Acetylcholinesterase Adducts by MALDI-TOF Mass Spectrometry. Biochemistry,
42:11083-11091 (2003).
173.
Khan, I., Osaka, H., Stanislaus, S., Calvo, R.M., Deernick, T., Yaksh, T.L. and Taylor, P. Nicotinic
Acetylcholine Receptor Distribution in Relation to Spinal Neurotransmission Pathways. J. Comp.
Neurol., 467:44-59 (2003).
174.
Henchman, R.H., Wang, H-L., Sine, S.M., Taylor, P. and McCammon, J.A. Asymmetric Structural
Motions of the Homomeric Alpha7 Nicotinic Receptor Ligand Binding Domain Revealed by Molecular
Dynamics Simulation. Biophys. J., 85:3007-3018 (2003).
175.
Comoletti, D., Flynn, R., Jennings, L.L., Chubykin, A., Matsumura, T., Hasegawa, H., Sudhof, T.C. and
Taylor, P. Characterization of the Interaction of a Recombinant Soluble Neuroligin-1 with neurexin1beta. J. Biol. Chem., 278:50497-50505 (2003).
176.
George, K.M., Schule, T., Sandoval, L.E., Jennings, L.L., Taylor, P. and Thompson, C.M.
Differentiation Between Acetylcholinesterase and the Organophosphate-inhibited Form Using
Antibodies and the Correlation of Antibody Recognition with Reactivation Mechanism and Rate. J.
Biol. Chem., 278:45512-45518 (2003).
177.
Saxena, A., Fedorko, J.M., Vinayaka, C.R., Medhekar, R., Radic, Z., Taylor, P., Lockridge, O. and
Doctor, B.P. Aromatic Amino-Acid Residues at the Active and Peripheral Anionic Sites Control the
Binding of E2020 (Aricept) to Cholinesterases. Eur. J. Biochem., 270:4447-4458 (2003).
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178.
Hoffman, R.C., Jennings, L.L., Tsigelny, I., Comoletti, D., Flynn, R.E., Sudhof, T.C. and Taylor, P.
Structural Characterization of Recombinant Soluble Rat Neuroligin 1: Mapping of Secondary Structure
and Glycosylation by Mass Spectrometry. Biochemistry, 43:1496-1506 (2004).
179.
Boyd, A.E., Dunlop, C.S., Wong, L., Radic, Z., Taylor, P. and Johnson, D.A. Nanosecond Dynamics of
Acetylcholinesterase Near the Active Center Gorge. J. Biol. Chem., 279:26612-26618 (2004).
180.
Kovarik, Z., Radic, Z., Berman, H.A., Simeon-Rudolf, V., Reiner, E. and Taylor, P. Mutant
Cholinesterases Possessing Enhanced Capacity for Reactivation of Their Phosphonylated Conjugates.
Biochemistry, 43:3222-3229 (2004).
181.
Bourne, Y., Kolb, H.C., Radic Z., Sharpless, K.B., Taylor, P. and Marchot, P. Freeze-frame Inhibitor
Captures Acetylcholinesterase in a Unique Conformation. Proc. Natl. Acad. Sci., 101:1449-1454
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182.
Comoletti, D., De Jaco, A., Jennings, L.L., Flynn, R.E., Gaietta, G., Tsigelny, I., Ellisman, M.H. and
Taylor, P. The Arg451Cys-Neuroligin-3 Mutation Associated with Autism Reveals a Defect in Protein
Processing. J. Neurosci., 24:4889-4893 (2004).
183.
Taylor, P., Hansen, S.B., Talley, T.T., Hibbs, R.E. and Radic, Z. Contemporary Paradigms for
Cholinergic Ligand Design Guided by Biological Structure. Bioorg. Med. Chem. Lett., 14:1875-1877
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184.
Hibbs, R.E., Talley, T.T. and Taylor, P. Acrylodan-conjugated Cysteine Side Chains Reveal
Conformational State and Ligand Site Locations of the Acetylcholine-binding Protein. J. Biol. Chem.,
279:28483-28491 (2004).
185.
Hansen, S.B., Talley, T.T., Radic, Z. and Taylor, P. Structural and Ligand Recognition Characteristics
of an Acetylcholine-binding Protein from Aplysia californica. J. Biol. Chem., 279:24197-24202 (2004).
186.
Bouzat, C., Gumilar, F., Spitzmaul, G., Wang, H-L., Rayes, D., Hansen, S.B., Taylor, P. and Sine, S.M.
Coupling of Agonist Binding to Channel Gating in an ACh-Binding Protein Linked to an Ion Channel.
Nature, 430:896-900 (2004).
187.
Manetsch, R., Krasinski, A., Radic, Z., Raushel, J., Taylor, P., Sharpless, K.B. and Kolb, H.C. In Situ
Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications. J. Amer. Chem. Soc.
126:12809-12818 (2004).
188.
Khan, I., Wennerholm, M., Singletary, E., Polston, K., Zhang, L., Deerinck, T., Yaksh, T.L. and Taylor,
P. Ablation of Primary Afferent Terminals Reduces Nicotinic Receptor Expression and the Nociceptive
Responses to Nicotinic Agonists in the Spinal Cord. J. Neurocytol., 33:543-556 (2004).
189.
Zhang, D., Suen, J., Zhang, Y., Song, Y., Radic, Z., Taylor, P., Holst, M.J., Bajaj, C., Baker, N.A. and
McCammon, J.A. Tetrameric Mouse Acetylcholinesterase: Continuum Diffusion Rate Calculations by
Solving the Steady-State Smoluchowski Equation Using Finite Element Methods. Biophysical Journal,
88:1659-1665 (2005).
190.
Gao, F., Bren, N., Burghardt, T.P., Hansen, S., Henchman, R.H., Taylor, P., McCammon, J.A. and Sine,
S.M. Agonist-mediated Conformational Changes in Acetylcholine-binding Protein Revealed by
16
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Simulation and Intrinsic Tryptophan Fluorescence. J. Biol. Chem., 280:8443-8451 (2005).
191.
Henchman, R.H., Wang, H-L., Sine, S.M., Taylor, P. and McCammon, J.A. Ligand-Induced
Conformational Change in the α7 Nicotinic Receptor Ligand Binding Domain. Biophysical Journal,
88:2564-2576 (2005).
192.
Chubykin, A.A., Liu, X., Comoletti, D., Tsigelny, I., Taylor, P. and Südhof, T.C. Dissection of
Synapse Induction by Neuroligins: Effect of a Neuroligin Mutation Associated with Autism. J. Biol.
Chem., 280:22365-22374 (2005).
193.
Bourne, Y., Talley, T.T., Hansen, S.B., Taylor, P. and Marchot, P. Crystal Structure of a Cbtx–AChBP
Complex Reveals Essential Interactions Between Snake -Neurotoxins and Nicotinic Receptors. The
EMBO Journal, 24:1512-1522 (2005).
194.
Krasinski, A., Radic, Z., Manetsch, R., Raushel, J., Taylor, P., Sharpless, K.B. and Kolb, H.C. In Situ
Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase
Inhibitors. J. Amer. Chem. Soc., 127:6686-6692 (2005).
195.
Boucard, A.A., Chubykin, A.A., Comoletti, D., Taylor, P. and Südhof, T.C. A Splice-Code for TransSynaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to - and -Neurexins. Neuron, In Press
(2005).
196.
Hansen, S.B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P. and Bourne, Y. Structures of
Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces
and conformations. The EMBO J., In Press (2005).
197.
Comoletti, D., Flynn, R.E., Boucard, A.A., Jennings, L.L., Shi, J., Tsigelny, I., Newlin, H.R., Südhof,
T.C. and Taylor, P. Gene Selection, Alternative Splicing, and Post-Translational Processing of
Neuroligin Regulate Selectivity for -Neurexins. Submitted to J. Biol. Chem. (2005).
198.
Gao, F., Mer, G., Tonelli, M., Hansen, S.B., Burghardt, T.P., Taylor, P. and Sine, S.M. Solution NMR
Demonstrates Agonist-mediated Conformational Change of the C-loop in Acetylcholine Binding
Protein. Submitted (2005).
Invited Contributions
1.
Taylor, P.W. Fast Reactions - Flow and Relaxation Methods; Chapter 10 in: Chignell, C.F. ed.,
Methods in Pharmacology, Vol. 2, Appleton-Century- Crofts, NY pp. 351-380 (1972).
2.
Taylor, P.W. Ligand Interactions with Carbonic Anhydrase: An Investigation of Mechanism using
Magnetic Resonance Relaxation and Rapid-Reaction Methods, J. Pharm. Sci. 64:501-508 (1975).
3.
Taylor, P. Rapid Reaction Methods and Their Use in Pharmacologic Systems, Symposium on Physical
Methods in Pharmacology, Proceedings 6th International Congress in Pharmacology, Helsinki,
Finland. July (1976).
4.
Taylor, P., Lwebuga-Mukasa, J., Berman, H. and Lappi, S. Spectroscopic Studies of Ligand Interactions
with Acetylcholinesterase, Proc. Int. Conference of Cholinesterases and Cholinergic Receptors, Split,
Yugoslavia, Croatia Chemica Acta 47:251-263 (1976).
17
02/12/16 6:15 PM
5.
Flanagan, S.D., Taylor, P. and Barondes, S.H. Purification of Acetylcholine Receptor Enriched
Membranes by the Use of Affinity Partitioning. Proc. Int. Conference of Cholinesterases and
Cholinergic Receptors, Split, Yugoslavia, Croatica Chemica Acta 47:449-458 (1976).
6.
Flanagan, S., Barondes, S.H. and Taylor, P. Affinity Partitioning of Receptor Rich Membrane Fractions
and Their Purification, Proc. of the Conference on Cell Surface Receptors, Bellagio, Italy, R. Bradshaw,
W.A. Frazier, R.C. Merell, D.J. Cottliet and R.A. Hogue-Angeletti, Eds., Plenum pp. 371-385 (1977).
7.
Taylor, P., Lwebuga-Mukasa, J., Lappi, S. and Berman, H.A. Structure of Acetylcholinesterase: Its
Relationship to the Postsynaptic Membrane, In: Cholinergic Mechanisms and Psychopharmacology,
D.J. Jenden, Ed. Plenum, New York pp. 239-251 (1977).
8.
Taylor, P. Regulation of Postsynaptic Sensitivity in Cholinergic Synapses, J. Daly, B. Hofer and R.K.
Dismukes, Editors, Neurosciences Res. Prog. Bull. 18:3, 361-368 (1980).
9.
Taylor, P. Anticholinesterase Drugs, In: Pharmacological Basis of Therapeutics, 6th Ed. (L.S.
Goodman, A. Gilman, A.G. Gilman, Eds.) Chpt. 10, Macmillan, New York, pp. 100-119 (1980).
10.
Taylor, P. Neuromuscular Blocking Agents, In: Pharmacological Basis of Therapeutics, 6th Ed. (L.S.
Goodman, A. Gilman, A.G. Gilman, Eds.) Chpt. 7, Macmillan, New York, pp. 220-234 (1980).
11.
Taylor, P. Ganglionic Stimulating and Blocking Agents, In: Pharmacological Basis of Therapeutics,
6th Ed. (L.S. Goodman, A. Gilman, A.G. Gilman, Eds.) Chpt. 11, Macmillan, New York, pp. 211-219
(1980).
12.
Taylor, P. Cholinergic Agonists, In: Pharmacological Basis of Therapeutics, 6th Ed. (L.S. Goodman, A.
Gilman, A.G. Gilman, Eds.) Chpt. 6, Macmillan, New York, pp. 91-99 (1980).
13.
Taylor, P. Weiland, G., Chignell, C.F. and Brown, R.D. Cholinergic Receptor State Transitions and
Local Anesthetic Action, In: Molecular Mechanisms of Anesthesia, B.R. Fink, Ed. Raven Press, NY,
175-188 (1980).
14.
Taylor, P. and Sine, S.M. The Relationship between Ligand Occupation and Activation of the Nicotinic
Cholinergic Receptor, Proceedings of the Second Nobel Conference - Chemical Transmission - 75
years, Academic Press, London (1981), Chpt. 31, pp. 347-359.
15.
Taylor, P. and Bartfai, T. Chairmen's Overview, Modulation and Transduction of Receptor Mediated
Signals: Proceedings Second Nobel Conference - Chemical Neurotransmission, Academic Press,
London, Chapter 38, pp. 425-428 (1981).
16.
Taylor, P. Drug Receptors: Considerations of their Functional Properties in Disease and
Pharmacologic Intervention, In: Current Concepts for Physicians - Therapeutic Principles, K.L.
Melmon, ed., Elsevier, pp 121-138 (1982).
17.
Taylor, P. and Sine, S.M. Ligand Occupation and the Functional States of the Nicotinic Cholinergic
Receptor, Trends in Pharmacological Sciences 3:197-201 (1982).
18.
Taylor, P. and Sine, S.M.
Ligand Occupation and the Functional Response of the Nicotinic
18
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Acetylcholine Receptor, In: Towards the Understanding of Receptors, Vol. II (J.W. Lamble, Ed.)
Elsevier, 125-133 (1982).
19.
Taylor, P., Johnson, D.A., and Brown, R.D. The Linkage between Ligand/ Occupation and Response of
the Nicotinic Acetylcholine Receptor, In: Advances in Membranes and Transport, Vol. 8 (A. Kleinzeller
and B.R. Martin, Eds.) Academic Press, Chapter 15, pp. 407-443 (1983).
20.
Taylor, P., Culver, P., Sine, S.M. and Johnson, D.A., The Coupling between Ligand Occupation and
Response of the Nicotinic Acetylcholine Receptor: Correlations with Receptor Structure, In: Mechanism
of Drug Action (T.P. Singer, T.E. Mansour and R.H. Ondarza, eds.) Academic Press, Orlando, pp. 9-27
(1983).
21.
Sine, S.M. and Taylor, P. Examination of Ligand Occupation and the Permeability Response of the
Nicotinic Acetylcholine Receptor on Intact Cells, In: Investigation of Membrane-Located Receptors (E.
Reid, G.M.W. Cook and D.J. Morre, eds.) Vol. 13, Methodological Surveys in Biochemistry and
Analysis. Plenum, pp. 369-380 (1984).
22.
Taylor, P., Camp, S., Lee, S., Amitai, G., Taylor, S. and Doctor, B.P., Molecular Aspects of the
Biosynthesis and Disposition of the Multiple Forms of Acetylcholinesterase, In: Cholinesterases,
Fundamental and Applied Aspects (M. Brzin, T. Kiauta and E.A. Barnard, eds.) Walter de Gruyter and
Co., Berlin, pp. 145-154 (1984).
23.
Taylor, P. Foreword Chapter, In: Receptors: Again (A. Abbott and J.W. Lamble, Eds.) Elsevier (1984).
24.
Cong, Z., Brown, R.D. and Taylor, P. Actions of Membrane-Active Drugs on Agonist Occupation and
the Functional State of the Nicotinic Acetylcholine Receptor. Acta Pharmacologica Sinica 6:231-236
(1985).
25.
Taylor, P. Anticholinesterase Agents, Chapter 6, Ligand Specificity of State Transitions in the
Cholinergic Receptor:Behavior of Agonists and Antagonists. In: Goodman and Gilman's The
Pharmacological Basis of Therapeutics, 7th ed. (A.G. Gilman, ed.) Macmillan, New York, pp. 110-129
(1985).
26.
Taylor, P. Neuromuscular Blocking Agents, Chapter 11, In: Goodman and Gilman's The
Pharmacological Basis of Therapeutics, 7th ed. (A.G. Gilman, ed.) Macmillan, New York, pp. 222-235
(1985).
27.
Taylor, P. Cholinergic Agonists, Chapter 5, In: Goodman and Gilman's The Pharmacological Basis of
Therapeutics, 7th ed. (A.G. Gilman, ed.) Macmillan, New York, pp. 100-109 (1985).
28.
Taylor, P. Ganglionic Stimulating and Blocking Agents, Chapter 10, In: Goodman and Gilman's The
Pharmacological Basis of Therapeutics, 7th ed. (AG Gilman, ed.) Macmillan, NY, pp. 215-221 (1985).
29.
Weiner, N. and Taylor, P. Neurohumoral Transmission: The Autonomic Nervous System and Somatic
Motor System, Chapter 4, In: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 7th
ed. (A.G. Gilman, ed.) Macmillan, New York, pp. 66-100 (1985).
30.
Taylor, P. Are Neuromuscular Blocking Agents More Efficacious in Pairs. Invited Editorial View,
Anesthesiology 63:1-3 (1985).
19
02/12/16 6:15 PM
31.
Taylor, P., Culver, P., Brown, R.D., Herz, J. and Johnson, D.A. An Approach to Anesthetic Action
from Studies of Acetylcholine Receptor Function, In: Molecular Mechanisms of Anesthesia Vol. III
(K.W. Miller and S. Roth, eds.) Plenum, pp. 99-110 (1986).
32.
MacPhee-Quigley, K., Vedvick, T.S., Taylor, P. and Taylor, S.S. Active Site and Other Sequence Data
from Torpedo californica Acetylcholinesterase, In: Modern Methods in Protein Chemistry (J. L'Italien,
ed.) Plenum Press, (1986).
33.
Schumacher, M., Camp, S., Maulet, Y., Newton, M., MacPhee-Quigley, K., Taylor, S.S., Friedmann, T.,
and Taylor, P. Primary Structure of Torpedo californica Deduced from its cDNA Sequence. Fed.
Proc., 45:2976-2980 (1986).
34.
Taylor, P., Schumacher, M., Maulet, Y. and Newton, M. A Molecular Perspective on the
Polymorphism of Acetylcholinesterase Structure. Trends in Pharmacological Sciences 7:321-324
(1986).
35.
Taylor, P., Herz, J., Johnson, D.A. and Brown, R.D. Topography of the Acetylcholine Receptor
Revealed by Fluorescence Energy Transfer, In: Nicotine Acetylcholine Receptor Structure and Function
(A. Maelicke, ed.), Springer-Verlag, pp. 61-75 (1986).
36.
Taylor, P. Functional Interdependence of Acetylcholinesterase and the Acetylcholine Receptor, In:
FESN Discussions in Neurosciences - Neurotransmitters, Vol. III, P. Magistretti, J. Morrison and T.
Reisine, eds. Geneva, pp. 29-34 (1986).
37.
Taylor, P., Schumacher, M., MacPhee-Quigley, K., Friedmann, T. and Taylor, S.S. The Primary
Structure of Acetylcholinesterase: Relationship to Function and Cellular Disposition. Trends in
Neuroscience 10:93-96 (1987).
38.
Friboulet, A., Gordon, D., Taylor, P. and Reiger, F. Evidence for the Interaction of Acetylcholinesterase
Inhibitors with "Catalytic" and "Extra-Catalytic" Sites on the Insolubilized Enzyme, In: Model Systems
in Neurotoxicity: Alternative Approaches to Animal Testing, Progress in Clinical and Biological
Research, 253:277-286 A. Shahar and A.M. Goldberg, Eds. (Liss, New York) (1987).
39.
Taylor, P., Culver, P., Abramson, S., Wasserman, L., Kline, T., and Fenical, W. Use of Selective
Toxins to Examine Acetylcholine Receptor Structure. In: Biomedical Importance of Marine Organism.
D.G. Fantin, ed. Memoirs California Acad. of Sci. 13: 109-114 (1988).
40.
Taylor, P. and Brown, J.H. Acetylcholine, Chapter 10 In: Basic Neurochemistry: Molecular, Cellular
and Medical Aspects, 4th Ed., Siegel, G.J., Albers, R.W., and Molinoff, P.B., Editors, Chapter 10,
Raven Press, N.Y., pp. 203-232 (1989).
41.
Taylor, P., Schumacher, M., Gibney, G., Maulet, Y. and Quigley, K. Molecular Studies of
Acetylcholinesterase Structure. Fernströ Symposium Series. L.C. Sellin, R. Libelius and S. Thesleff,
Editors, Elsevier, Amsterdam, Vol. 13., pp. 301-310 (1989).
42.
Ludgate, M., Dong, Q., Dreyfus, P.A., Zakut, M., Taylor, P., Vassart, G. and Soreq, H. Definition at the
Molecular Level of a Thyroglobulin-acetylcholinesterase Shared Epitope: Study of its Pathophysiological Significance in Patients with Graves Opthalmopathy. Autoimmunity 3:167-176 (1989).
20
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43.
Taylor, P. and Insel, P.A. Molecular Basis of Drug Action, Chapter 2 In: Principles of Drug Action. 3rd
Edition. W.B. Pratt and P. Taylor eds. Churchill Livingstone, New York, pp. 103-200 (1990).
44.
Taylor, P. and Insel, P.A. Molecular Basis of Pharmacological Specificity, Chapter 1 In: Principles of
Drug Action, 3rd Edition, W.B. Pratt & P. Taylor, eds., Churchill-Livingstone, Inc., New York, pp. 1102 (1990).
45.
Taylor, P. Acetylcholinesterase Agents, Chapter 7 In: Goodman & Gilman's The Pharmacological
Basis of Therapeutics, A.G. Gilman, T.W. Rall, A.S. Nies and P. Taylor, Eds., Pergamon Press, N.Y.,
pp. 131-149 (1990).
46.
Taylor, P. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia, Chapter 9 In:
Goodman & Gilman's The Pharmacological Basis of Therapeutics, A.G. Gilman, T.W. Rall, A.S. Nies
and P. Taylor, Eds., Pergamon Press, N.Y., pp. 166-186 (1990).
47.
Taylor, P. Cholinergic Agonists. In: Goodman & Gilman's The Pharmacological Basis of
Therapeutics, Chapter 6, A.G. Gilman, T.W. Rall, A.S. Nies and P. Taylor, Eds., Pergamon Press, N.Y.,
pp. 122-130 (1990).
48.
Lefkowitz, R.J., Hoffman, B.B. and P. Taylor, P. The Autonomic and Somatic Motor Nervous Systems,
Chapter 4 In: Goodman and Gilman's The Pharmacological Basis of Therapeutics, A.G. Gilman, T.
Rall, A.S. Nies and P. Taylor, Eds., Pergamon Press, N.Y., pp. 84-121 (1990).
49.
Taylor, P., Traynor-Kaplan, A., Ambler, S.K., Thompson, B., Poenie, M., Tsien, R.Y. and Sklar, L.
Fingerprinting of Ligand Mediated Cellular Activation: Relationships Between Inositol Phosphates,
Phosphatidyl Inositols, Intracellular Calcium and Cell Function. In: Calcium Channel Modulators in
Heart and Smooth Muscle, S. Abraham and G. Amitai, Eds., VCH Weinheim, Germany, pp. 43-45
(1990).
50.
Reece, J., Brown, R.D., Cain, C., Amitai, G., Segall, Y. and Taylor, P. Purification and Labeling of the
1-Adrenergic Receptor. In: Calcium Channel Modulators in Heart and Smooth Muscle, S. Abraham
and G. Amitai, Eds., VCH Weinheim, Germany, pp. 125-138 (1990).
51.
Abramson, S.N. and Taylor, P. Identification of Nicotinic Receptor Acetylcholine Binding Subunits
(Letter). Trends in Neuroscience, 13:92 (1990).
52.
Tao, T.-W., Leu, S.-L., Taylor, P. and Kriss, J.P. Reactivity to Thyroglobulin and Acetylcholinesterase.
Acta Endocrinologica 121:(Suppl.2) pp. 46-50 (1990).
53.
Taylor, P., Gibney, G., Camp, S., Maulet, Y., Ekström, T., Rachinsky, T. and Li, Y. Features of
Acetylcholinesterase Structure and Gene Expression Emerging from Recent Recombinant DNA Studies.
Proc. Third Int. Conference on Cholinesterases, J. Massoulie, J.P. Toutant, D. Quinn and B.P. Doctor,
eds., ACS Books, Washington, D.C., pp. 179-185 (1991).
54.
Taylor, P., Abramson, S.N., Johnson, D.A., Valenzuela, C.F. and Herz, J. Distinctions in Ligand
Binding Sites on the Nicotinic Acetylcholine Receptor. In: Molecular and Cellular Mechanisms of
Alcohol and Anesthetics, E. Robin, K.W. Miller and S.H. Roth, eds. Annals New York Academy of
Sciences, 625:568-587 (1991).
21
02/12/16 6:15 PM
55.
Taylor, P. Cholinesterases. Minireview, J. Biol. Chem., 266:4025-4028 (1991).
56.
Taylor, P., Li, Y., Camp, S., Rachinsky, T.L. and Getman, D. Acetylcholinesterase Gene Expression
and Organization. In: Current Research in Alzheimer Therapy. Giacobini, E. and Becker, R. (eds)
Birkhäuser, Boston, pp. 53-62 (1991).
57.
Abramson, S.N., Fenical, W. and Taylor, P. The Lophotoxins: Irreversible Active Site Directed
Inhibitors of Nicotinic Acetylcholine Receptors. Current Trends Review, Drug Development Research,
24:297-312 (1991).
58.
Taylor, P., Abramson, S., Fenical, W. and Faulkner, D.J. Marine Toxins that Affect Cholinergic
Neurotransmission, In: Marine Pharmacology: Prospects for the 1990's, R.S. Jacobs and M.
deCarvalho, ed. California Sea Grant College, NOAA, La Jolla, CA, (1992).
59.
Getman, D. and Taylor, P. Structure and Organization of the Acetylcholinesterase Gene Locus Implications for Alzheimer's Disease. Bulletin of Clinical Neurosciences 4:65-72 (1992).
60.
Massoulie, J., Sussman, J., Doctor, B.P., Soreq, H., Velan, B., Cygler, M., Rotundo, R., Shafferman, A.,
Silman, I. and Taylor, P. Recommendations for Nomenclature on Cholinesterases. Proc. 36th Oholo
Conference, A. Shafferman & B. Velan, eds., Plenum, N.Y., pp. 285-288 (1992).
61.
Taylor, P. Impact of Recombinant DNA Technology and Protein Structure Determination on Past and
Future Studies on Acetylcholinesterase, Plenary Lecture, Proceedings 36th Oholo Conference, A.
Shafferman & B. Velan, eds., Plenum Press, N.Y., pp.1-15 (1992).
62.
Taylor, P., Li, Y., Camp, S., Radic, Z., Getman, D., Rachinsky, T.L., Ekström, T.L., Fuentes, M.E.,
Kawamoto, S., Vellom, D.C. and Pickering, N.A. Acetylcholinesterase: Regulation of Expression of its
Gene and Modification of Enzyme Structure. Proceedings 4th Yokohama International Medical
Seminar, Yokohama Medical Bulletin, 43: 146-157 (1992).
63.
Taylor, P. Cholinesterases. In: Cytoskeletal and Structural Proteins. Pollard, T., Cleveland, D., Franke,
W., Kreis, T., Reichardt, L., Geiger, B. and Vale, R. eds. Sambrock and Tooze Publishers, pp. 30-32
(1993).
64.
Taylor, P., Li, Y., Camp, S., Rachinsky, T.L., Ekstrom, T., Getman, D., Fuentes, M.E., Vellom, D.C.
and Radic, Z. Structure and Regulation of Expression of the Acetylcholinesterase Gene. Chem. Biol.
Interactions 87:199-207 (1993).
65.
Hutchison, D.O., Engel, A.G., Walls, T.J., Nakano, S., Camp, S., Taylor, P., Harper, C.M., Brengman,
J.M. The Spectrum of Congenital End-plate Acetylcholinesterase Deficiency. Ann. N.Y. Acad. Sci. 681:
469-486 (1993).
66.
Taylor, P. and Brown, J.H. Acetylcholine. In: Basic Neurochemistry: Molecular, Cellular and Medical
Aspects. 5th Ed., Siegel, G.J., Albers, R.W. and Molinoff, P.B., Editors, Chapter 10, Raven Press, N.Y.,
pp. 231-260 (1993).
67.
Taylor, P. and Radic, Z. The Cholinesterases: From Genes to Proteins. Ann. Rev. Pharmacol. 34:281320 (1994).
22
02/12/16 6:15 PM
68.
Taylor, P., Radic, Z., Kreienkamp, H-J., Maeda, R., Luo, Z., Fuentes, M.E., Vellom, D. and Pickering,
N. Gene Expression and Ligand Specificity of Acetylcholinesterase and the Nicotinic Receptor: A Tale
of Distinction at Two Cholinergic Sites, Biochemical Journal (Transactions). 22:740-745 (1994).
69.
Taylor, P., Ross, E.M., Sigler, P.B. and Sykes, B.D. Foundations and Future of Molecular
Pharmacology. In: Pharmacological Sciences: Perspectives for Research and Therapy in the Late
1990's. Edited by A.C. Cuello and B. Collier, Birkhauser Verlag, Basel, Switzerland. pp. 59-66 (1995).
70.
Taylor, P., Radic, Z., Kreienkamp, H.-J., Luo, Z. and Camp, S. Gene Expression and Ligand Specificity
in the Cholinergic Synapse: A Comparison Between Acetylcholinesterase and the Nicotinic
Acetylcholine Receptor. In: Enzymes of the Cholinesterase Family. (D. Quinn, B.P. Doctor and P.
Taylor, Eds.) Plenum Press, N.Y., 15-22 (1995).
71.
Radic, Z., Quinn, D.M. and Vellom, D.C. Amino Acid Residues in Acetylcholinesterase Which
Influence Fasciculin Inhibition. In: Enzymes of the Cholinesterase Family. (D. Quinn, B.P. Doctor
and P. Taylor, Eds.) Plenum Press, N.Y., 183-188 (1995).
72.
Marchot, P., Camp. S., Radic, Z., Bougis, P.E. and Taylor, P. Structural Determinants of Fasciculin
Specificity for Acetylcholinesterase. In: Enzymes of the Cholinesterase Family. (D. Quinn, B.P.
Doctor and P. Taylor, Eds.) Plenum Press, N.Y., 197-202 (1995).
73.
Quinn, D.M., Seravalli, J., Nair, H.K., Medhekar, R., Husseini, B., Radic, Z., Vellom, D.C., Hosea,
N.A. and Taylor, P. The Function of Electrostatics in Acetylcholinesterase Catalysis. In: Enzymes of the
Cholinesterase Family (D. Quinn, B.P. Doctor and P. Taylor, eds.) Plenum Press, N.Y., pp.203-206
(1995).
74.
Ashani, Y., Radic, Z., Tsigelny, I., Vellom, D.C., Hosea, N.A., Quinn, D.M., Doctor, B.P. and Taylor, P.
Amino Acids that Control Mono- and Bisquaternary Oxime-Induced Reactivation of O-Ethyl
Methylphosphonylated Cholinesterase. In: Enzymes of the Cholinesterase Family (D. Quinn, B.P.
Doctor, and P. Taylor, eds.) Plenum Press, N.Y., pp.133-140 (1995).
75.
Taylor, P., Radic, Z., Hosea, N.A., Camp, S., Marchot, P. and Berman, H.A. Structural Bases for the
Specificity of Cholinesterase Catalysis and Inhibition. In: Toxicology Letters. 82/83, 453-458 (1995).
76.
Taylor, P., Acetylcholinesterase. In: Encyclopedia of Neuroscience. Vol. I, G. Adelwein and B.M.
Smith, eds., Elsevier, Amsterdam, p. 11-13, (1996).
77.
Hoffman, B.B., Lefkowitz, R.J., and Taylor, P. Neurohumoral Transmission: The Autonomic and
Somatic Motor Nervous Systems. In: Goodman & Gilman's The Pharmacological Basis of
Therapeutics, 9th ed. (Hardman, J.L. and Limbird, L.E., eds.) Chapter 6, pp 105-139 (1996).
78.
Brown, J.H. and Taylor P. Muscarinic Receptor Agonists and Antagonists. In: Goodman & Gilman's
The Pharmacological Basis of Therapeutics. (Hardman, J.L. and Limbird, L.E., eds.) Chapter 7, pp 141160, McGraw-Hill, New York (1996).
79.
Taylor P. Anticholinesterase Agents. In: Goodman & Gilman's The Pharmacological Basis of
Therapeutics. (Hardman, J.L. and Limbird, L.E., eds.) Chapter 8, pp 161-176, McGraw-Hill, NY
(1996).
23
02/12/16 6:15 PM
80.
Taylor, P. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia. In: Goodman &
Gilman's The Pharmacological Basis of Therapeutics. (Hardman, J.L. and Limbird, L.E., eds.) Chapter
9, pp 177-198, McGraw-Hill, New York (1996).
81.
Taylor, P., Hosea, N.A., Tsigelny, I., Radic, Z. and Berman, H.A. Determining Ligand Orientation and
Transphosphonylation Mechanisms on Acetylcholinesterase by Rp, Sp Enantiomer Selectivity and SiteSpecific Mutagenesis. Enantiomer, 2:249-260 (1997).
82.
Taylor, P., Ross, E.M., Sternweis, P.C., Neubig, R.R. and McCammon, J.A. Colloquium on Signaling
and Molecular Structure in Pharmacology. Mol. Pharmacol., 52:1-5 (1997).
83.
Taylor, P. Metrifonate: A viewpoint Drugs and Aging, 11:497-498 (1997).
84.
Bourne, Y., Taylor, P. and Marchot, P. Acetylcholinesterase, A Recombinant, Monomeric
(mouse)/Fasciculin 2 (mamba) Complex. In: Macromolecular Structures, 1996 Part 1 (W.
Hendrickson, ed.,) Current Biology Ltd. (1998).
85.
Marchot, P., Bourne, Y., Prowse, C.N. Bougis, P.E. and Taylor, P. Inhibition of Mouse
Acetylcholinesterase by Fasciculin: Crystal Structure of the Complex and Mutagenesis of Fasciculin.
Toxicon., 36:1613-1622 (1998).
86.
Taylor, P. Development of Acetylcholinesterase Inhibitors in the Therapy of Alzheimer's Disease, Ann.
Neurol., 51:S30-S35 (1998).
87.
Limbird, L.E. and Taylor, P. Endocrine Disruptors Signal the Need for Receptor Models and
Mechanisms to Inform Policy, Cell 93:157-164 (1998).
88.
Camp, S. and Taylor, P. Intronic Elements Appear Essential for the Differentiation-Specific Expression
of Acetylcholinesterase in C2C12 Myotubes. In: Structure and Function of Cholinesterases and Related
Proteins, Edited by B.P. Doctor, P. Taylor, D.M. Quinn, R.L. Rotundo and M.K. Gentry, Plenum Press,
NY, pp. 51-57 (1998).
89.
Malany, S., Sikorski, R.S., Seravalli, J., Medhekar, R., Quinn, D.M., Radic, Z., Taylor, P., and Velan, B.
Structure of the Acylation Transition State for Acetylcholinesterase Catalysis. In: Structure and
Function of Cholinesterases and Related Proteins, Edited by B.P. Doctor, P. Taylor, D.M. Quinn, R.L.
Rotundo and M.K. Gentry , Plenum Press, NY, pp. 197-202 (1998).
90.
Radic, Z. and Taylor, P. The Effect of Peripheral Site Ligands on the Reaction Kinetics of Phosphyl and
Carboxyl Esters with Acetylcholinesterase. In: Structure and Function of Cholinesterases and Related
Proteins, Edited by B.P. Doctor, P. Taylor, D.M. Quinn, R.L. Rotundo and M.K. Gentry, Plenum Press,
NY, pp. 211-214 (1998).
91.
Bourne, Y., Taylor, P., Kanter, J., Bougis, P.E., and Marchot, P. Crystal Structure of Mouse
Acetylcholinesterase. In: Structure and Function of Cholinesterases and Related Proteins, Edited by B.P.
Doctor, P. Taylor, D.M. Quinn, R.L. Rotundo and M.K. Gentry, Plenum Press, NY, pp. 315-322 (1998)
92.
Marchot, P., Bourne, Y., Prowse, C., Kanter, J., Eads, J., Bougis, P., and Taylor, P. Fasciculin
Inhibition of Mouse Acetylcholinesterase. In: Structure and Function of Cholinesterases and Related
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Proteins, Edited by B.P. Doctor, P. Taylor, D.M. Quinn, R.L. Rotundo and M.K. Gentry, Plenum Press,
NY, pp. 331-335 (1998).
93.
Tsigelny, I., Matsumura, T., Sudhof, T., and P. Taylor. Metal Binding Motifs in Cholinesterases and
Neuroligins. . In: Structure and Function of Cholinesterases and Related Proteins, Edited by B.P.
Doctor, P. Taylor, D.M. Quinn, R.L. Rotundo and M.K. Gentry, Plenum Press, NY, pp. 407-412 (1998).
94.
Taylor, P., Osaka, H., Molles, B.E., Sugiyama, N., Marchot, P., Malany, S., McArdle, J.J., Sine, S.M.
and Tsigelny, I. Toxins Selective for Subunit Interfaces as Probes of Nicotinic Acetylcholine Receptor
Structure. J. Physiol. 92:79-83 (1998).
95.
Taylor, P. and Brown, J.H. Acetylcholine. In: Basic Neurochemistry: Molecular, Cellular and Medical
Aspects, 1998 (Siegel, G.J., Agranoff, B.S., Albers, R.W., Fisher, S.K. and Uhler, M.D., eds.,) 6th Ed.,
Lippincott-Raven Philadelphia, pp. 213-242 (1998).
96.
Taylor, P. Cholinesterases. In: Guidebook to the Extracellular Matrix and Adhesion Proteins, 2nd Ed.,
(Kries, T. and Vale, R., eds.,) Oxford, pp. 377-379 (1999).
97.
Taylor, P., Wong, L., Radic, Z., Tsigelny, I., Hosea, N.A. and Berman, H.A. Analysis of
Cholinesterase Inactivation and Reactivation by Systematic Structural Modification and Enantiomeric
Selectivity. Proc. Third. Int. Meeting on Esterases Reacting with Organophosphorus Compounds,
Chem. Biol. Int., 119-120:3-15 (1999).
98.
Radic, Z. and Taylor, P. The Influence of Peripheral Site Ligands on the Reaction of Symmetric and
Chiral Organophosphates with Wild Type and Mutant Acetylcholinesterases. Proc. Third Int. Meeting
on Esterases Reacting with Organophosphorus Compounds. Chem. Biol. Int., 119-120:111-118 (1999).
99.
Luo, C., Saxena, A., Ashani, Y., Leader, H., Radic, Z., Taylor, P. and Doctor, B.P. Role of
Edrophonium in Prevention of the Re-Inhibition of Acetylcholinesterase by Phosphorylated Oxime. In:
Proc. Third Meeting on Esterases Reacting with Organophosphorus Compounds, Chem. Biol. Int.,
Elsevier, 119-120, pp. 129-136 (1999).
100.
Xie, W., Wilder, P.J., Stribley, J., Chatonnet, A., Rizzino, A., Taylor, P., Hinrichs, S.H. and Lockridge,
O. Knockout of One Acetylcholinesterase Allele in the Mouse. Chem.-Biol. Int. 119-120:289-299
(1999).
101.
Keller, S. and Taylor, P. Determinants Responsible for Assembly of the Nicotinic Acetylcholine
Receptor. J. Gen. Physiol. (Invited Perspectives) 113:1-6 (1999).
102.
Lukas, R., Changeux, J-P, Novere, N., Albuquerque, E., Balfour, D., Bertrand, D., Chiappinelli, V.,
Clarke, B., Collins, A., Dani, J., Grady, S., Kellar, K., Lindstrom, J., Marks, M., Quik, M., Taylor, P.,
Wonnacott, S. International Union of Pharmacology. XX. Current Status of the Nomenclature for
Nicotinic Acetylcholine Receptors and Their Subunits. Pharmacological Reviews, 51:396-401 (1999).
103.
Taylor, P., Osaka, H., Molles, B. and Malany, S. Contributions of the Nicotinic Receptor from Muscle
to Defining the Structural and Functional Properties of Ligand-Gated Ion Channels. Chapter 2 In:
Neuronal Nicotinic Receptors , F. Clementi, C. Gotti and D. Formaseri, eds. Handbook of Experimental
Pharmacology, Springer-Verlag, pp. 79-100 (2000).
25
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104.
Taylor, P., Luo, Z.D., and S. Camp. The Genes Encoding the Cholinesterases: Structure, Evolutionary
Relationships and Regulation of their Expression. In: Cholinesterases and Cholinesterase Inhibitors
(Chapter 5), E. Giacobini (ed), Martin Dunitz, London, pp. 63-80 (2000).
105.
Radic Z., Kovarik, Z., Wong, L., Bruggemann, R.J.M., Hosea, N., Berman, H.A. and Taylor, P.
Mechanism of Oxime Reactivation of Phosphonylated Acetylcholinesterase Analyzed by Chirality
and Mutagenesis. Bioscience Reviews, pp. 56-65 (2000).
106.
Hoffman, B. and Taylor, P. Neurotransmission: The Autonomic and Somatic Motor Systems. In:
Goodman & Gilman’s The Pharmacological Basis of Therapeutics 10th Edition, Chapter 6. (J.G.
Hardman and L.E. Limbird, eds.) McGraw-Hill, New York. pp. 115-154 (2001).
107.
Brown, J.H. and Taylor, P. Muscarinic Receptor Agonists and Antagonists. In: Goodman & Gilman's
The Pharmacological Basis of Therapeutics 10th Edition, Chapter 7. (J.G. Hardman and L.E.
Limbird, eds.) McGraw-Hill, New York. pp. 155-174 (2001).
108.
Taylor, P. Anticholinesterase Agents. In: Goodman Gilman's The Pharmacological Basis of
Therapeutics 10th Edition, Chapter 8. (J.G. Hardman and L.E. Limbird, eds.) McGraw-Hill, New
York. pp. 175-192 (2001).
109.
Taylor, P. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia. In: Goodman &
Gilman's The Pharmacological Basis of Therapeutics 10th Edition, Chapter 9. (J.G. Hardman and
L.E. Limbird, eds.) McGraw-Hill, New York. pp. 193-214 (2001).
110.
Radic, Z. and Taylor, P. Peripheral Site Ligands Accelerate Inhibition of Acetylcholinesterase by
Neutral Organophosphates. J. Appl. Toxicol., 21:S13-S14 (2001).
111.
Taylor, P., Molles, B., Malany, S. and Osaka, H. Toxins as Probes for Structure and Specificity of
Synaptic Target Proteins. In: Perspectives in Molecular Toxinology, A. Menez, editor, J.W. Wiley,
New York, pp. 271-281 (2002).
112.
Satoh, T., Taylor, P., Bosron, W.F., Sanghani, S.P., Hosokawa, M. and La Du, B.N. Symposium
Article: Current Progress on Esterases: From Molecular Structure To Function. Drug Metabolism
and Disposition, 30:488-493 (2002).
113.
Molles, B. and Taylor, P. Structure and Function of the Waglerins, Peptide Toxins from the Venom
of Wagler’s Pit Viper, Tropidolaemus Wagleri. Toxicon Reviews, 21: 273-292 (2002).
114.
Taylor, P. René Couteaux Lecture: Ligand Recognition in the Cholinergic Nervous System Analysed by
Structural Templates and Protein Dynamics. In: Cholinergic Mechanisms: Function and Dysfunction,
Silman, I., Soreq, H., Anglister, L., Michaelson, D. and Fisher, A., eds., Taylor and Francis, New York,
pp.81-86 (2004).
115.
Radic, Z., Kim, E. and Taylor, P. Intrinsic Trytophan Fluorescence of Cholinesterases: Direct,
Nonperturbing Monitoring of Enzyme-Ligand Interactions. In: Cholinergic Mechanisms: Function and
Dysfunction, Silman, I., Soreq, H., Anglister, L., Michaelson, D. and Fisher, A., eds., Taylor and
Francis, New York, pp.171-175 (2004).
116.
Comoletti, D., Flynn, R., Jennings, L.L., Hoffman, R., Marchot, P., Bourne, Y., Sudhof, T. and Taylor,
26
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P. Interaction of Recombinant Soluble Neuroligin-1 With Neurexin-1-β. In: Cholinergic Mechanisms:
Function and Dysfunction, Silman, I., Soreq, H., Anglister, L., Michaelson, D. and Fisher, A., eds.,
Taylor and Francis, New York, pp.523-525 (2004).
117.
Kovarik, Z., Radic, Z., Berman, H.A. and Taylor, P. Phosphonylation of Acetylcholinesterase and the
Propensity for Reactivation Analysed by Chilarity and Mutagenesis. In: Cholinergic Mechanisms:
Function and Dysfunction, Silman, I., Soreq, H., Anglister, L., Michaelson, D. and Fisher, A., eds.,
Taylor and Francis, New York, pp.611-612 (2004).
118.
Luo, C., Leader, H., Radic, Z., Maxwell, D.M., Taylor, P., Doctor, B.P. and Saxena, A. Two Possible
Orientations of the HI-6 molecule in the Reactivation of Organophosphate-Inhibited
Acetylcholinesterase. In: Cholinergic Mechanisms: Function and Dysfunction, Silman, I., Soreq, H.,
Anglister, L., Michaelson, D. and Fisher, A., eds., Taylor and Francis, New York, pp.627-630 (2004).
119.
Shi, J., Radic, Z., Boyd, A.E., Johnson, D.A. and Taylor, P. Ligand-Induced Conformational Changes
in the Omega Loop of Acetylcholinesterase Revealed by Fluorescence Spectroscopy. In: Cholinergic
Mechanisms: Function and Dysfunction, Silman, I., Soreq, H., Anglister, L., Michaelson, D. and
Fisher, A., eds., Taylor and Francis, New York, pp.695-696 (2004).
120.
Camp, S., Zhang, L., Marquez, M. and Taylor, P. Knockout Mice with Deletions of Alternatively
Spliced Exons of Acetylcholinesterase. VII International Meeting on Cholinesterase, Pucon – Chile.
Inestrosa, N.C. and Campos, E.O., eds., Cholinesterases in the Second Millennium: Biomolecular and
Pathological Aspects pp. 43-47 (2004).
121.
Taylor, P., Shi, J., Radic, Z., Boyd, A.E. and Johnson, D.A. Spectroscopic Approaches to the Study
of Acetylcholinesterase Structure and Function. Cholinesterases in the Second Millennium:
Biomolecular and Pathological Aspects pp. 177-180 (2004).
122.
Radic, Z., Kim, E. and Taylor, P. Monitoring Cholinesterase – Ligand Interactions. Cholinesterase in
the Second Millennium: Biomolecular and Pathological Aspects pp. 201-206 (2004).
123.
Kovarik, Z., Wong, L., Radic, Z. and Taylor, P. Phosphorylation of Mouse Cholinesterases and
Mutants by DDVP and Reactivation of Conjugates by HI-6 and 2-PAM. Cholinesterases in the
Second Millennium: Biomolecular and Pathological Aspects pp. 219-221 (2004).
124.
Shi, J., Radic, Z., Johnson, D.A. and Taylor, P. Analysis of Acetylcholinesterase Structure and
Dynamics by Steady State and Time-resolved Fluorescence. Cholinesterases in the Second
Millennium: Biomolecular and Pathological Aspects pp. 225-227 (2004).
125.
Jennings, L.L., Komives, E.A. and Taylor, P. Organophosphate Modifications of Mouse
Acetylcholinesterase: Detection of Exposure by MALDI-TOF Mass Spectrometry. Cholinesterases in
the Second Millennium: Biomolecular and Pathological Aspects pp. 265-268 (2004).
121.
Taylor, P. Acetylcholinesterase. Encyclopedia of Neuroscience. G. Adelman and B.H. Smith, eds.
3rd Edition on CD-ROM (2004).
122.
Kovarik, Z., Radic, Z. and Taylor, P. Site-directed mutagenesis of acetylcholinesterase – a tool for
studying structure/function relationship. Periodicum biologorium 106:289-294 (2004).
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123.
Taylor, P. and Brown, J.H. Acetylcholine. In: Basic Neurochemistry: Molecular, Cellular and Medical
Aspects 7th Edition, Chapter 11. (Siegel, G.J., Albers, R.W., Fisher, S., Brady, S.T., and Price, D.L.,
eds.) Lippincott-Raven Philadelphia. In Press (2005).
124.
Camp, S., Zhang, L., Marquez, M., de la Torre, B., Long, J.M., Bucht, G. and Taylor, P.
Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of
selected exon and regulatory region deletion. VIII International Meeting on Cholinesterase. ChemBiol. Interactions, In Press (2005).
125.
Kovarik, Z., Radic, Z., Berman, H.A., Simeon-Rudolf, V., Reiner, E. and Taylor, P. Reactivation of
Phosphonylated Acetylcholinesterase Analyzed by Chilarity and Mutagenesis. VIIIth International
Symposium on Protection against Chemical and Biological Warfare Agents, Gothenburg, Sweden. In
Press (2005).
126.
Taylor, P. and Brown, J.H. Muscarinic Agonists and Antagonists. In: Goodman Gilman's The
Pharmacological Basis of Therapeutics 11th Edition, Chapter 7. (L.L. Brunton, ed.) McGraw-Hill,
New York. Pp. 183-200 (2005).
127.
Taylor, P. Acetylcholinesterase Agents. In: Goodman Gilman's The Pharmacological Basis of
Therapeutics 11th Edition, Chapter 8. (L.L. Brunton, ed.) McGraw-Hill, New York. Pp. 201-216
(2005).
128.
Taylor, P. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia. In: Goodman
Gilman's The Pharmacological Basis of Therapeutics 11th Edition, Chapter 9. (L.L. Brunton, ed.)
McGraw-Hill, New York. Pp. 217-236 (2005).
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