ULTIMATE ALOE® - Page 1 of 11 ULTIMATE ALOE® FIVE REASONS TO CHOOSE ULTIMATE ALOE® 1. PURE WHOLE LEAF ALOE VERA LINNE GEL 2. 100% STABILIZED – ALL NATURAL 3. ALOIN FREE 4. POLYSACCHARIDE RICH 5. CONTAINS MORE ACTIVE COMPONENTS THAN ALOE GEL Instructions: SHAKE WELL BEFORE USE. Drink 2-4 ounces per day or as desired as a dietary supplement. Can be mixed with other beverages. Tastes best cold. Store unopened bottle at room temperature (60°-80°F). Refrigerate after opening. Ultimate Aloe® Ingredients: Whole leaf Aloe Vera Linne gel, purified water, ascorbic acid, sodium benzoate, potassium sorbate, citric acid, malic acid and carmel. Cranberry Apple Ultimate Aloe® Ingredients: Whole leaf Aloe Vera Linne gel, purified water, ascorbic acid, natural cranberry flavor, fructose, natural apple flavor, sodium benzoate, potassium sorbate, citric acid, and malic acid. Strawberry-Kiwi Ultimate Aloe® Ingredients: Whole leaf Aloe Vera concentrate, purified water, fructose, natural strawberry-kiwi flavor, ascorbic acid, sodium benzoate, and potassium sorbate added to enhance freshness. ULTIMATE ALOE® - Page 2 of 11 Frequently Asked Questions (FAQ’s) 1. What is the active ingredient content? The active ingredient content is a minimum of 220 mg per liter. 2. How much Aloe Vera is in Ultimate Aloe®? There is a minimum of 100 mg Aloe Vera per ounce. 3. What is the polysaccharide content? The polysaccharide content is a minimum of 2000 mg per liter. 4. What is the number of active ingredients? There are approximately 175 active ingredients in the Ultimate Aloe®. 5. What is the amount of triglycerides in Ultimate Aloe®? Ultimate Aloe® contains 28-44 mg per 3.36 ounces. 6. How many calories per serving? Per bottle? There are approximately 2 calories per serving with approximately 16 servings per bottle, which would be 32 calories per bottle. 7. How much potassium does Ultimate Aloe® contain? There is about 4-5 mg of potassium per liter. 8. What is the shelf life of Ultimate Aloe®? If un-refrigerated and unopened, Ultimate Aloe® will last approximately one year. 9. Is Ultimate Aloe® FDA approved? No. Ultimate Aloe® is classified as a vegetable drink and is not regulated by the FDA. It follows all of the guidelines the FDA sets forth for juice production. 10. Is Ultimate Aloe® safe for diabetics? Some research has shown Aloe to be helpful in both controlling diabetes and aiding healing of diabetes-induced injuries. If there is any doubt, consult a physician. If a diabetic wants to try the Ultimate Aloe® after you have cautioned him, recommend that he use the regular flavor. Cranberry Apple has added sugar. Some feel Ultimate Aloe® helps to burn excess sugar and helps the body to use insulin more efficiently. 11. What kind of problems might Ultimate Aloe® help? Ultimate Aloe® has been said to help with allergies, abrasions, arthritis, burns, blisters, colds, headaches, hemorrhoids, inflammation, lupus, multiple sclerosis, nausea, psoriasis, poison ivy, stings, tendonitis, ulcers, varicose veins, acne, indigestion, insomnia, anemia and gingivitis. 12. What does MPS mean? MPS is the abbreviation for “Methanol Precipitable Solids”, and refers to a test to determine the amount of total solids contained in a solution – in other words, the total active ingredients. Aloe contains numerous polysaccharides, including mucopolysaccharides. ULTIMATE ALOE® - Page 3 of 11 13. Is Ultimate Aloe® cold-processed? According to our manufacturer – NO, it is pasteurized. Pasteurization is the process by which the product is rid of bacteria to prevent contamination and spoilage. In fact, several studies show that the active ingredients can be enhanced by heating. 14. How can Ultimate Aloe® be 150%? 100% Aloe juice is referred to by the Aloe industry as 1X or 1.0. It is also the percent of total solids, which is normally between 0.75-0.92% while the rest is water (99.25-99.08%). 150% Aloe is 50% stronger (contains 50% more solids – 1.125-1.38%). It is therefore referred to as 150% or 1.5X. Ultimate Aloe® is actually 150%+, since it contains a minimum of 1.50% solids. 15. What is the concentration of Aloe in the different flavors? All flavors are 150%. 16. Why is Carmel added to the Regular flavor? The Carmel is added to the product to obtain the dark brownish color. 17. Why are Sodium Benzoate and Potassium Sorbate in the Aloe Juices? Small amounts are added as preservatives. 18. Why does the taste vary? The taste will vary from lot to lot due to the seasonal time of harvest. The sun and the amount of water the plants receive are directly responsible for the ripeness of the plants. Just as with any vegetable, you will have a different taste depending upon the growing process. 19. The label on the bottles include something called malic acid. Why is that added? The malic acid was added to further promote freshness and aid in the adjusting of the pH level. 20. On the label there is Linne gel? What is it? Linne is the name of the person given credit for categorizing plants and animals. Aloe is the genus and vera is the species. The type of aloe in our product is Aloe barbadensis Miller. Miller described and categorized the plant we know as Aloe vera. QUALITY OF ULTIMATE ALOE® Our manufacturer harvests and processes Aloe Vera according to guidelines of time, temperature and sanitation. A patent is pending on this Aloe process. Strict, sanitary manufacturing practices use specific time and temperature guidelines to preserve the natural properties of the Aloe Vera plant. The quality of Ultimate Aloe® is tested through quality control parameters including various devices for analyzing chemical and physical characteristics, and in-vitro assays for monitoring biological activity. Our manufacturer is the only supplier with a full range of biological, chemical and medicinal R&D capabilities. Superior products deliver high quality with added benefits to the consumer – and consumers expect a more effective and consistent product they can depend on time after time. ULTIMATE ALOE® - Page 4 of 11 Aloe Vera leaves are normally sensitive to subfreezing temperatures after several hours. Since occasional arctic cold fronts move down through Southern Texas, weather can be a ruinous factor to an Aloe Vera processing schedule. With that in mind, our manufacturer thought it prudent to grow a large, additional supply of Aloe Vera leaves further south in Mexico. The Harvest Aloe is harvested by pulling back on the green leaf and cutting at the white base. Approximately three of the outermost mature leaves are cut from each plant. Leaves are gathered in boxes which are transported immediately to the production facility. Back at the building, production employees feed incoming harvested leaves into the primary washer located just outside the production room. The production room has a stainless steel conveyor system that quickly moves harvested leaves from the primary wash tank outside through a small opening in the wall into the room. The conveyors propel leaves to the mechanical leaf washer, then to the cutting area, and finally through the gel expulsion machines. The production room is kept in an ultra-sanitary state, even when not in use. Employees are required to go through a process of sanitation every time they enter the room and the entire area is thoroughly cleaned after each production run. Once the gel is expelled from the leaves, it is pumped through a de-pulping machine. The pure Aloe gel is then moved through a chilling system designed to bring the temperature of the gel down to 37 degrees Fahrenheit. The chilled gel is stored in an insulated tank, ready to be pumped into a transport tanker for delivery to the processing facility. It is important to use Aloe Vera that has been processed in a manner to stabilize the Aloe and stop the enzymes from continuing to break down the polysaccharides. This normally has to be done in the first 4-6 hours after severing the leaf from the mother plant. By doing so we preserve the bio-active content of the Aloe, which we have found to be the 50-100,000 molecular weight (mw or dalton) polysaccharides. Most processors fail to do this and end up with 5-50,000 daltons which has much less bio-active capability (shown in immune restoration and cell proliferation studies). ULTIMATE ALOE® - Page 5 of 11 THE BENEFITS OF WHOLE LEAF ALOE VERA Ultimate Aloe® has the maximum amount of desired components. It contains 150% or more of the IASC (INTERNATIONAL ALOE SCIENCE COUNCIL) requirement of 100% Aloe vera in polysaccharides, glycoproteins, urea nitrogen, creatine, potassium, calcium, magnesium, zinc, phosphorus, iron, choline, sodium, alkaline phosphates, SGO transaminase, SGP transaminase, lactic dehydrogenase, amylase, lipase, mono and polyunsaturated fatty acids, amino acids, saponins, sterols, and biogenic stimulators. The Ultimate Aloe® manufacturer selectively removes undesirable components such as aloin and other anthraquinones (Aloin: 1ppm or less). This was confirmed by an independent university laboratory. The Ultimate Aloe® taste has improved. Method used to concentrate product eliminates over 95% of Aloe’s bitter taste resulting in improved flavor. Natural cranberry, apple and strawberry flavors have been added to make the product taste great. Children as well as adults will find the flavors enjoyable. A higher concentration of healing factors (components believed to be responsible of immune stimulation) is part of the improved benefits. Ultimate Aloe® contains 3 times more polymers than Aloe gel and fifty percent (50%) more active components than required to achieve maximum benefit when consumed as directed. The concentration of Ultimate Aloe® makes retail cost approximately one-half that of most health food store products. ULTIMATE ALOE® - Page 6 of 11 Aloe Vera – Medicine Plant Background The idea that Aloe vera is an effective treatment for a broad spectrum of skin conditions is as old as the Pyramids. It was first described in the Papyrus Ebers, an Egyptian medical book written between 1553-50 B.C.E. The ground whole leaf of the plant has been used as a medicinal agent or cosmetic ingredient for thousands of years. There are two forms of extracts derived from the Aloe vera plant. The first being a clear mucilaginous gel which is collected from the cells in the leaf parenchyma. This gel can be used either fresh or stabilized. The second is the juice, a colorless or milky substance, is collected by allowing the plant to drain. If you look at the history of Aloe as a topical treatment or cosmetic ingredient, there are three types of evidence which has been used to support its value, including testimonials, medical research and chemical analysis. Reports show that as early as the 1930’s the gel was used in successful treatment of X-ray and radium burns. Studies were also done on its effectiveness for thermal burns. However, the reports of these experiments and the numerous favorable case histories did not give conclusive evidence, and have subsequently been challenged. Usually the results were described as favorable but the work was viewed as poor experimental design or a small sample test. Many individuals apply the gel to minor cuts, abrasions, and burns. Most of the modern research has focused on Aloe vera’s ability to alleviate, heal, and eliminate skin diseases, disorders, and injuries. These outcomes are supported by over 1000 modern clinical studies conducted by medical professionals that report dramatic results. According to a 1982 study conducted at the University of Chicago Burn Center, the results in the treatment of burn patients attributed to Aloe vera are so miraculous as to seem more like myth than fact. Hundreds of chemical reports show that Aloe contains vitamins, minerals, amino acids, enzymes, and a large number of medicinal compounds. Some reports identify individual and multiple compounds found in the plant as the healing agents. According to Wendell Winters of the University of Texas Health Science Center at San Antonio there are at least 140 healing agents. Although the FDA has reviewed data from testimonies, clinical studies, and chemical analyses, it is their official opinion that this information does not prove that Aloe vera has any great value as a skin treatment. Most health food stores display the product on their shelves. The product is used in a wide variety of applications such as: as a laxative, as a treatment of irritable bowel syndrome, to relieve digestive conditions resulting from inflammation and even to promote healthier skin. The public is using Aloe vera to self-medicate or complement existing medical treatment of these conditions. Testimonials talk about how the yellow juice softens skin, eliminates pain and the long term damage of sunburn, fades age spots, speeds the healing of burns, skin ulcers, boils, and many other severe skin injuries, controls dermatitis and a myriad of other skin diseases. ULTIMATE ALOE® - Page 7 of 11 Aloe as a Cosmetic Ingredient Aloe growers and manufacturers, in association with the IASC and its predecessor, the National Aloe Science Council (NASC), have worked wince the early 80’s to develop inspection procedures and chemical tests that could be used by the FDA to assure consumers that all Aloe products live up to the claims on their labels. Despite these efforts, little progress has been made. Currently there is very little government interest in the Aloe industry. The industry is virtually unregulated. Aloe does not look, taste, or smell like water. It is yellow or reddish yellow in color, has a sharp or bitter taste, and a mile onion or garlic like odor. To see for yourself, obtain an Aloe leaf, macerate the whole leaf in a blender and look at the results. This is fresh, pure whole leaf Aloe. The best way to help determine whether or not your purchase is real is to become familiar with the taste, color, smell, and the benefits of fresh Aloe. WHY WHOLE LEAF Modern chemical analysis of Aloe leaves shows that the active agents that are responsible for the plants widely celebrated healing properties are concentrated in the green skin (rind) and yellow sap (latex) which is found just under the skin. The same and many other studies show that the get (thick center of the leaf) should be included in all Aloe products because it acts as a buffering agent to soothe and cool body tissue. The juice of Aloe contains at least 99.1% water which means that the polysaccharides (acemannan and other polypeptides), glycoproteins, and other components constitute less than 1% of the juice. To date, over 200 active components have been identified including antiinflammatory fatty acids, antiseptic, analgesic, and immune-stimulating compounds. Therefore, we know that the amazing benefits of Aloe are produced by relatively small amounts of many components, acting together synergistically to produce benefits that no single agent can produce alone. ALOIN-FREE WHOLE LEAF ALOE Fresh whole leaf Aloe vera juice contains aloin, a very powerful laxative, which must be eliminated from the juice if it is to be used safely as an ingredient in topical products or as a health drink. Aloin is a compound which is produced from e-modin and glucose. When whole leaf Aloe is pasteurized and the aloin is eliminated, the juice is safe for both topical and internal use. 100% STABILIZED FOR MAXIMUM EFFECTIVENESS The Aloe vera plant is classified as a vegetable and like all plant products the juice must be preserved or it will rapidly decompose when the leaves are processed. Therefore, preservatives are added during processing to retard the growth of micro-organisms. Potassium sorbate (from Mountain Ash trees) and sodium benzoate (from benzoin gum) are used in minute quantities as preservatives, and ascorbic and citric acid (from citrus) as antioxidants to stabilize and provide pH balance. ULTIMATE ALOE® - Page 8 of 11 Nutritional Value of Aloe vera Chemical analysis shows that Aloe vera contains vitamins, minerals, triglycerides, carbohydrates, amino acids, enzymes, and of course, water. The vitamins found in Aloe include B-complex, B1, B2, B3 and B12, choline, folic acid, vitamin C, and beta-carotene (a precursor to vitamin A) – all of which are vital to general good health in body systems and some of which are vital for the formation of certain enzymes. Minerals: Aloe has been shown to contain as many as 13 of the 17 minerals needed for good nutrition. Minerals found in Aloe include calcium, magnesium, potassium, chloride, iron, zinc, manganese, copper, chromium, sulfur, aluminum, strontium, boron, silicon, lithium, phosphorus, nickel and sodium. All these minerals are vital in the growth process and essential for the function of all body systems. Triglycerides: Triglycerides include fats, oil, and waxes. They carry the fat soluble vitamins, supply the fatty acids essential for growth and general health of all body tissue and help supply energy. Carbohydrates: Carbohydrates assist in digestion and assimilation of nutrients in food and supply energy for muscular exertion. They also control protein breakdown, the distribution of sodium, potassium, chloride, and water for electrolyte balance. Identified carbohydrates include glucose, mannose and acemannan. Amino Acids: Aloe vera juice contains twenty of the twenty-two amino acids known to be needed for good nutrition; nine of these are essential and must be supplied from an outside source because the body cannot manufacture its own. The other thirteen can be synthesized by the body from the essential nine. Aloe has been shown to contain all of the essential nine. The complete list of amino acids know to exist in Aloe include lysine, histidine, arginine, aspartic acid, asparagine, threonine, serine, glutamine, hydroproline, proline, glycine, alanine, cystine, valine, methionine, isoleucine, leucine, tyrosine, glutamic acid, and phenylalanine. Enzymes: Without enzymes, the chemical reaction of vitamins, minerals, and hormones cannot take place. They also aid in reducing indigestion and inflammation of ulcers. Enzymes present in Aloe include: alkaline phosphates, SGO transaminase, SGP transaminase, lactic dehydrogenase, amylase, lipase, oxidase, peroxidase, catalase, bradykinase, gamma transaminase, carboxypeptidase, and cellulase. Biogenic agents: Aloe contains 6 or more biogenic agents to stimulate new cell growth. They include cinnaminic and salicylic acids. Water: Water is the major component of Aloe vera gel (the clear inner part of the leaf). When the fiber or pulp is removed from the gel, what remains is approximately 99 per cent water. Water is the universal solvent and is responsible for the transfer of nutrients throughout the body. ULTIMATE ALOE® - Page 9 of 11 CHEMISTRY – THE KEY TO UNDERSTANDING Aloe vera works because the green skin of the plant produces and the sap stores at least 6 antiseptic agents: lupeol, salicylic acid, urea nitrogen, cinnamonic acid, phenol, and sulfur. All of these substances are clinically recognized for their ability to eliminate infection because they kill or control micro-organisms including fungi, bacteria, and viruses. In addition, the plant also produces at least 23 proteins, (polypeptides) and at least 4 mannan sugars which regulate cell growth and stimulate the immune system (biogenic stimulators). These agents greatly increase the skin’s own defenses against infections by improving immune function. Polypeptides and mannans are the building blocks for new, healthy cells. They are more abundant in young skin cells. As aging occurs, the amount of polypeptides and mannans in the cell diminishes. Topical application of an Aloe product helps provide ample concentrations of these agents for the proper formation of healthy cells. Polypeptides and mannans are two of the reasons Aloe helps to heal skin injuries with reduced scarring. The skin and yellow sap (latex) of the Aloe vera plan contain at least 3 anti-inflammatory fatty acids (HDL cholesterol, campesterol, and beta-sitosterol). They represent cortisone-like compounds which make Aloe extremely effective in treating the inflammation associated with burns, cuts, abrasions and skin diseases, as well as a treatment for ulcers of all kinds. The presence of beta-sitosterol explains why topical Aloe vera is effective in skin allergies and irritations, and why it helps to balance out the HDL and LDL cholesterol in the skin. Aloe’s betasitosterol also acts as a vasodilator to increase circulation on the surface of the skin. Cholesterol, campesterol, and beta-sitosterol are plant sterols that are responsible for Aloe’s effectiveness as an excellent moisturizer. Traumatic acid and allantoin (FDA approved for minor skin problems) are also found in the skin and sap, are would healing agents. Lupeol, salicylic acid, and plant magnesium are highly effective analgesics which explains why Aloe is a topical painkiller. Aloe contains at least three cancer fighting compounds. Lectins induce systemic anti-tumor immunity. Aloe-emodin and Aloe mannans have been shown to control many types of skin cancers. Aloe also contains small amounts of PABA (para-amino benzoic acid), a natural sunscreen, which lessens the likelihood of sun-induced damage. Aloe’s acemannan has been FDA approved for AIDS treatment trials in a Canadian double-blind, placebo controlled study. Injectable acemmanan has been approved by the USDA as a veterinary treatment for fibro sarcoma. ULTIMATE ALOE® - Page 10 of 11 L K References to Support Ultimate Aloe® as a Dietary Supplement Agarwal, O.P. Prevention of Atheromatous Heart Disease. Angiology: The Journal of Vascular Diseases. 36 (8), 485-92, 1985. Ashleye, A.D. Applying heat during processing of the commercial Aloe vera gel. Erde International 1, 40-44, 1083. Bland, J., Effect of orally consumed Aloe vera juice on gastro-intestinal function in normal humans. Linus Pauling Institute of Science and Medicine, Palo Alto, AC, 1985. Boggs, U. and Zessin G.: On the Preparation of Aloe Extract With a Suggestion for DAB 7. Pharmazie 21 (9), 547-550, Sept., 1966. Cobble, H.H. U.S.Patent #3,892,853. Stabilized Aloe Vera Gel and Preparation of Same, July 1, 1975. Cole, H.N. and Cole, K.K., Aloe Vera in Oriental Dermatology. Arch. Dermat. And Sympt, Vol. 47, PP. 250, 1943. Collins, E.E. and Collins, C. Roentgen Dermatitis Treated with Fresh Whole Leaf of Aloe Vera, Am. J. Roentgenol. Vol. 33, 396-397, 1935. Cope, O. The Burn Problem. U.S. Office of Scientific Research, Vol. 1, 1948. Crewe, J.E. Aloes in the Treatment of Burns and Scalds, Minn. Med., Vol. 22, 538-539, Aug. 1938. Farkas, A. Polysaccharide Product Derived from the Juice of the Aloe Plant and Methods for Preparing Same; U.S. Patent #3,362,951; Jan. 9, 1968. Fly, L.B., Kiem, I. Tests of Aloe vera for Antibiotic Activity; Economic Botany, Vol. 14, pps 4649, 1963. Fujita, K., Teradaira, R. and Nagatsu, T. Bradykinase Activity of Aloe Extract, Biochemical Pharmacology, 25 (2), pp. 205, Jan. 1976. Gjerstad, G. An appraisal of the Aloe vera juice; College of Pharmacy, University of Texas, Austin. Vol. 84: pps. 43-46, 1969. Gjerstad, G and Riner, T.D. Current Status of Aloe as a Cure-All. Am. J. of Pharm, 140 (2): 5864, 1968. Hartwell, J.L. Plants used against cancer. A survey. Lloydia, 34 (2) 204-255, June 1971. Kahlon, J.B. et al. In vitro evaluation of the synergistic antiviral effects of acemannan in combination with azedothymidine and acyclovir. Molecular Biotherapy, Vol 3, 214-223, Dec., 1991. ULTIMATE ALOE® - Page 11 of 11 Kemp, M.C. et al. In vitro evaluation of the anti-viral effects of acemannan on the replication and pathogenesis of HIV-1 and other enveloped viruses: modification of the processing of glycoprotein precursors. Abstract 84, The Third International Conference on Antiviral Research. April 22-27, 1990. Northway, R.B. Experimental use of Aloe vera extract in clinical practice. Veterinary Medicine/Small Animal Clinician 70, 89, 1975. Pulse, T.L. and Uhlig, Elizabeth. A significant Improvement in a Clinical Pilot Study Utilizing Nutritional Supplements, Essential Fatty Acids and Stabilized Aloe vera Juice in 29 HIV Seropositive ARC and AIDS Patients. Study abstract, Nov, 1989. Robson, M.C., J.P. Heggers, W.J. Hagstrom. Myth, magic, witchcraft, or fact? Aloe vera revisited. American Burn Association Abstracts 31, 65-66, 1980. Rubel, B.L. Possible mechanisms of the healing actions of Aloe gel. Cosmetics and Toiletries 98, 109-114, 1983. Sakai, R., Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet. Japanese Journal of Cancer Research 80: 513-520, 1989. Sheets, M.A. et al. Studies of the effect of acemannon on retrovirus infections: clinical stabilization of feline leukemia virus-infected cats. Veterinary Microbiology 3: 41-45, 1991. Winters, W.D., R. Benavides, W.J. Clause. Effects of Aloe extracts on human; Normal and tumor cells in vitro. Economic Botany 35, 89-95, 1981.