First Four-Way Meeting on “Bird Flu”: Palestinians, Jordanians, Israelis, and Egyptians Coordinate on Avian Influenza Risk Israeli, Jordanian, Egyptian, and Palestinian health and veterinary officials met in Istanbul December 11-14, 2005, and discussed a framework for regional cooperation to prepare for the possibility of a deadly influenza pandemic. They agreed to develop recommendations for cooperation and coordination on disease surveillance, risk communication, vaccination, training, research, and the movement of people and goods before and during a “bird flu” outbreak. While there have been Israeli-Jordanian and Israeli-Palestinian meetings since the “bird flu” made headlines in the Mediterranean region in early October, this was the first meeting in which experts from all four nations participated. These experts met under the umbrella of the Middle East Consortium on Infectious Disease Surveillance (MECIDS). The goals of MECIDS are to improve the ability of nations in the Middle East to respond to outbreaks of disease and to build mutual trust through trans-border cooperation. It was founded by Search for Common Ground, a global conflict-transformation organization, and the NTI Global Health and Security Initiative, which focuses on strengthening global disease surveillance, early detection and rapid response. The meeting featured experts from the various disciplines required to respond to influenza outbreaks, such as epidemiology, hospital administration, laboratory testing, and veterinary services. They discussed objectives and actions for the pandemic phases defined by the World Health Organization (WHO), and across categories also defined by the WHO, namely: 1. Planning and coordination 2. Situation monitoring and assessment 3. Prevention and containment 4. Health system response 5. Communications They agreed on a program of activities that they could undertake, as well as some recommendations they could pass to the decision-makers in their countries, to cooperate, coordinate, and assist each other in these different areas. Together, these constitute a “Framework for Regional Influenza Preparedness.” National Plans Presented At the conference, countries presented their national pandemic influenza preparedness plans. Following World Health Organization recommendations, all four have formed national coordinating committees. Presentations on the plans can be viewed at www.mecids.net. Expert Presentations World-renowned influenza expert Robert Webster of St. Jude’s Children’s Research Hospital presented an in-depth discussion of the nature of avian influenza and suggested that the development of a vaccine should be the highest priority of health officials. The head of Malaysia’s Epidemic Intelligence Service described her country’s experience with avian influenza, and a representative of the WHO Global Influenza Programme spoke about international planning efforts. Finally, representatives of ProMed-Mail, the Global Public Health Intelligence Network (GPHIN), IBM, and the Cooperative Monitoring Center @ Amman elaborated several possible ways to use telecommunications technology to enhance disease surveillance. Their presentations can be viewed at www.mecids.net. Framework for Regional Influenza Preparedness Planning and Coordination: The many subjects that arose require further elaboration and ongoing cooperation. The participating nations will meet monthly at the King Hussein/Allenby Bridge border crossing point to manage the emerging situation and work in depth on agreed-upon subjects. A proposed schedule for the meetings is as follows: January: February: March: April: June: July: August: MECIDS strategy and fundraising Risk Communication Disease Surveillance Avian Vaccine Policy Movement Issues Training Applied Research Surveillance Meeting participants discussed several aspects of disease surveillance, focusing on the types of information needed and the information flow within and among countries. To facilitate the rapid sharing of data about suspected avian and pandemic influenza cases, they recommended that nations take the following steps: Write common epidemiological investigation guidelines. Create common reporting form. Agree on common case definition. Conduct survey of laboratory capacity. Agree on who, what, where, when, why, and how for reporting both suspected and confirmed cases to each other. Meet with representatives of IBM to discuss upgrading cross-border communications technologies. Prevention and Containment: The primary subject discussed in the category of prevention and containment was the movement of people and goods among the territories of the participating nations. Their intermingled populations, combined with the unresolved political and security conflicts among them, create a special set of problems. The group identified the following issues: Access between the West Bank and Gaza. The number of West Bank checkpoints. The Allenby/King Hussein Bridge border crossing. The movement of goods. Animals Foodstuffs. Airports. Access to hospitals. Communication The participants agreed on objectives for risk communication about an influenza outbreak. • To cooperate in preparing a regional communication plan for pandemic influenza • To harmonize national public health messages in the region • To coordinate local plans ensuring that they do not contain major contradictory messages to the public • To assist each other in developing risk communication materials • To explain differences in public health actions in the countries of the region Training The participants agreed to pursue a comprehensive series of training courses on both avian influenza and pandemic influenza. The trainings would cover different processes related to influenza surveillance and response and would be geared toward specific target audiences, as follows: Process Surveillance Laboratories Clinics General hospitals Management Target population: Avian Influenza Agriculture: veterinaries MOH: PH physicians and nurses Human; Veterinary Physicians and nurses Target population: Pandemic Influenza MOH: PH physicians and nurses Physicians and nurses Infection control specialist Senior health care officers in community clinics, general hospitals and the ministry of health Physicians and nurses Infection control specialist Senior health care officers in community clinics, general hospitals and the ministry of health Human; Physicians and nurses Risk communication Healthcare professionals who are experts in the subject (preferably a mix of academicians, hospitals well known experts, etc) Healthcare professionals who are experts in the subject (preferably a mix of academicians, hospitals well known experts, etc) Tabletop exercise Healthcare system; Country level; Region level 5 Healthcare professionals per country Healthcare system; Country level; Region level 5 Healthcare professionals per country Train the trainer Participants also planned to look for established educational materials regarding avian and pandemic influenza that have been developed by other agencies, such as the United States Centers for Disease Control and Prevention, the European Centre for Disease Control, the WHO, and other national health ministries. They agreed that Search for Common Ground should send a letter to these agencies requesting material, which they will then adapt to the needs of the Middle East. Israeli experts proposed that a pandemic influenza training CD and video they developed be translated into Arabic and shared with their Palestinian and Jordanian colleagues. The Cooperative Monitoring Center @ Amman offered to host a training session and to put educational material on the MECIDS web site. Research Participants at the meeting discussed possible research strategies regarding avian influenza and agreed that training and research should be integrated. Topics for joint applied research in the region to support preparedness against influenza pandemic (discussed and agreed upon at the meeting in Istanbul, December 2005) 1. Assessment and monitoring of the risk of exposure to avian flu strains using the model of serotype H9N2 Cross-sectional serological studies to determine the prevalence rates of H9N2 among subjects with occupational exposure to avian flu strains (poultry farmers, veterinarians etc.) Follow-up studies with baseline collected sera and periodical additional sampling to monitor the extent of exposure to H9N2 and other avian flu serotypes. (identify new subjects who show seroconversion in a "high risk cohort" under serologic surveillance) 2. Assessment of potential cross-protection conferred by serotype H9N2 against infection caused by serotype H5N1 3. Comparative molecular characterization of H9N2 isolates from Israel, Jordan and Palestinian Authority. Evaluation of the extent of genetic polymorphism among the regional isolates in comparison with H9N2 strains isolated all over the world. Conclusion: Participants praised the unique opportunity offered by the meeting. They were enthusiastic about continuing to work together.