Standard Operating Procedures Laboratory SpecificChemical: Lithium hydroxide Please fill out the form completely. Print a copy and insert into your Laboratory Safety Manual and Chemical Hygiene Plan. Refer to instructions for assistance. _____________________________________________________________________________ Department:__ Chemistry_________ Date when SOP was written: _ 11/27/2012 _ Date when SOP was approved by the lab supervisor: _1/13/2013__________________ Principal Investigator: __ Richmond Sarpong __________ Internal Laboratory Safety Coordinator/Lab Manager: ____ Rebecca Murphy ________________ Laboratory Phone: _ 510-643-2485 __ Office Phone: __ 510-643-6312 ____ Emergency Contact: ___ Richmond Sarpong 626-644-2407 __________ (Name and Phone Number) Location(s) covered by this SOP: _ Latimer 834, 836, 837, 838, 839, 842, 844, 847, 849, 907 __ (Building/Room Number) _____________________________________________________________________________ Type of SOP: Process Hazardous Chemical Hazardous Class Purpose Lithium hydroxide is an inorganic compound with the formula LiOH. It is a white hygroscopic crystalline material. It is soluble in water and slightly soluble in ethanol. It is available commercially in anhydrous form and as the monohydrate (LiOH.H2O), both of which are strong bases. Lithium hydroxide is mainly consumed for the production of lithium greases. It is used as a heat transfer medium and as a storage-battery electrolyte. It is also used in ceramics and some Portland cement formulations. Lithium hydroxide (isotopically enriched in lithium-7) is used to alkalize the reactor coolant in pressurized water reactors for corrosion control. Physical & Chemical Properties/Definition of Chemical Group CAS# 1310-65-2 Class: Hazardous Chemical, Corrosive Molecular Formula: LiOH Form (Physical State): Solid white powder or pellets (often found in aqueous solution) Boiling Point: N/A SOP Template developed by The UC Center for Laboratory Safety 1 1/11/2013 Melting point: 450°C (842°F) Potential Hazards/Toxicity Very hazardous in case of skin contact, eye contact, ingestion, and/or inhalation. Corrosive to eyes and skin. The amount of tissue damage depends on length of contact. Eye contact can result in corneal damage or blindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking, unconsciousness or death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Acute toxicity Oral LD50 [mouse] 363 mg/kg Oral LD50 [rat] 210 mg/kg Dust LC50 [rat] 960 mg/m3 4 hours Engineering Controls NOTE: Specific information on engineering controls is to be added to the Protocol/Procedure section. Work with lithium hydroxide should be conducted in a fume hood unless other controls are designated in the Protocol/Procedure section. Sash height should be kept low to avoid escaping fumes and provide a physical barrier. Consider using a face shield when handling the pure material. Personal Protective Equipment (PPE) NOTE: Specific information on PPE selection is to be added to the Protocol/Procedure section. Respiratory protection . NOTE: Lab personnel intending to use/wear a respirator mask must be trained and fit-tested by EH&S. This is a regulatory requirement. Respirators should be used only under any of the following circumstances: As a last line of defense (i.e., after engineering and administrative controls have been exhausted). When Permissible Exposure Limit (PEL) has exceeded or when there is a possibility that PEL will be exceeded. Regulations require the use of a respirator. An employer requires the use of a respirator. There is potential for harmful exposure due to an atmospheric contaminant (in the absence of PEL) As PPE in the event of a chemical spill clean-up process Hand protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Type of gloves recommended for potassium hydroxide: standard nitrile. SOP Template developed by The UC Center for Laboratory Safety 2 1/11/2013 For handling concentrated solutions of potassium hydroxide, thicker nitrile gloves or doublegloving is recommended. NOTE: Lab-specific and chemical-specific information on glove selection may be included in the Protocol/Procedure section. Refer to glove selection from the link below: For glove selection, go to: http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-andusage.html. Eye protection Safety glasses with side shields or tightly fitting safety goggles. Use face shield (8-inch minimum) when appropriate. Use equipment for eye protection tested and approved under appropriate government standards such as ANSI Z87.1, NIOSH (US) or EN 166(EU). Skin and body protection Long pants, closed-toed and closed-heeled shoes, cotton-based clothing/attire, and apron/lab coat of a chemically inert material must be worn for protecting against chemical hazards. Hygiene measures Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling. First Aid Procedures Notify supervisor and EH&S immediately. Follow up with a call to 510-642-9090 to report the incident. If inhaled Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. In case of skin contact Take off contaminated clothing immediately. Wash off with soap and plenty of water for 15 minutes. Take victim immediately to hospital. Consult a physician immediately. In case of eye contact Check for and remove any contact lenses. Rinse thoroughly with plenty of water for at least 15 minutes using an emergency eyewash station, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Continue to wash eyes during transport to the hospital. If swallowed Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician immediately. Special Handling and Storage Requirements NOTE: Specific information on handling and storage is to be added to the Protocol/Procedure section. SOP Template developed by The UC Center for Laboratory Safety 3 1/11/2013 Working alone Certain extremely hazardous operations should not be performed if the PI or Lab Safety Contact(s) are not present. Never work alone with extremely hazardous materials/operations. See the Protocol/Procedure section below for specific prohibitions (if any) on working alone. Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. A fume hood should be used when handling lithium hydroxide powder and when preparing solutions of lithium hydroxide. Always add lithium hydroxide to water while stirring; never the reverse. Provide adequate cooling capacity (e.g ice bath) when preparing concentrated solutions of lithium hydroxide as it reacts exothermically with water. Conditions for safe storage Lithium hydroxide is hygroscopic; store in a cool, dry area with the container tightly closed to minimize absorption of water from the air. Store in a secondary container with other bases segregated away from acids, flammables, and oxidizers. Cabinets where significant quantities of lithium hydroxide and/or other acids and bases are stored must be labeled with the hazard warning “Corrosive.” All corrosives greater than or equal to 1M in concentration must be stored in secondary containment at all times. Spill and Accident Procedure Chemical Spill Dial 911 and 510-642-9090 Spill – Help contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. Eliminate sources of ignition if the chemical is flammable. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.). Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up. Large (>1 L) – Dial 911 and EH&S at 510-642-9090 for assistance. Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S immediately. Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by using an emergency eyewash station and forcibly holding the eye open. Seek medical attention immediately. Notify supervisor and EH&S immediately. Medical Emergency Dial 911 and 510-642-9090 Life Threatening Emergency, After Hours, Weekends And Holidays – Dial 911 or go to the nearest Occupational Health Facility or emergency room if it is after hours. Note: All serious injuries must be reported to EH&S within 8 hours at 510-642-9090 SOP Template developed by The UC Center for Laboratory Safety 4 1/11/2013 Non-Life Threatening Emergency– Go to the Occupational Health Facility (OHF). At all other times report to the emergency room. Note: All serious injuries must be reported to EH&S at within 8 hours at 510-642-9090. Needle stick/puncture exposure (as applicable to chemical handling procedure)– Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse. At all other times report to the emergency room. Note: All needle stick/puncture exposures must be reported to EH&S within 8 hours at 510-642-9090. Decontamination/Waste Disposal Procedure Instruments (carefully) and benches contaminated with lithium hydroxide should be decontaminated with soap and water. All lithium hydroxide waste and contaminated disposables should be disposed of as hazardous waste according the guidelines below. General hazardous waste disposal guidelines: Label Waste • Label all containers with the label provided at http://ehs.berkeley.edu/hm/279-new-hazardous-waste-program-hwp.html. See the EH&S Fact Sheet, “Hazardous Waste Management” for general instructions on procedures for disposing of hazardous waste. Dispose of Waste • Dispose of regularly generated chemical waste within 6 months. • Call EH&S for questions. Safety Data Sheet (SDS) Location SDS can be accessed online at http://ucmsds.com Protocol/Procedure for Lithium Hydroxide Preparation Reactivity/ Stability: Lithium hydroxide solution neutralizes acids exothermically to form salts plus water. Reacts with certain metals (such as aluminum and zinc) to form oxides or hydroxides of the metal and generate gaseous hydrogen. Conditions to Avoid: Avoid moisture, air. Incompatibilities/Materials to Avoid: strong acids, carbon dioxide. When not in use, keep container tightly closed in a dry and well-ventilated place. Store and transport THF containers in secondary containment (for example polyethylene bottle carrier). Know the location of the nearest fire extinguisher, eyewash, and safety shower before beginning work. SOP Template developed by The UC Center for Laboratory Safety 5 1/11/2013 Lab-specific Information All work for this procedure is to take place in the designated fume hood. Wear proper PPE. Keep Lithium hydroxide e containers tightly closed in a dry and well-ventilated place away from incompatible substances. Procedure/Use Scale Using lithium hydroxide as a reagent in a chemical reaction Up to 100 g PI approval required for larger amounts. Engineering Controls/Equipmen t All work dealing with solid lithium hydroxide should be conducted on a clean benchtop in a chemical fume hood. PPE (eye, face, gloves, clothing) Procedure Steps and Precautions Eye protection: Wear tight-fitting safety goggles or safety glasses with side shields. Consider a face shield when handling the pure material. Measure out the desired quantity of lithium hydroxide by transferring the white solid to a tarred plastic weigh boat positioned on a balance using a metal spatula. Solutions of lithium hydroxide in organic solvents should be handled in a ventilated fume hood. Face protection: Wear a face shield when not protected by a lab hood sash. Add the lithium hydroxide slowly to the desired reaction vessel in a fume hood. Slow addition avoids the generation of excess heat. Gloves: Wear reusable rubber, nitrile, or neoprene gloves. Clothing: Wear apron/lab coat of chemically inert material, full length pants or equivalent; and close-toed closed heeled shoes. Dilute any lithium hydroxide that was spilled during the above processes with copious amounts of water and use paper towels to soak up the resulting solution. Dispose of any paper towels in a chemically contaminated waste container. NOTE Any deviation from this SOP requires approval from PI. Documentation of Training (signature of all users is required) Prior to conducting any work with lithium hydroxide, designated personnel must provide training to his/her laboratory personnel specific to the hazards involved in working with the specific chemical(s) used, work area decontamination, and emergency procedures. SOP Template developed by The UC Center for Laboratory Safety 6 1/11/2013 The Principal Investigator must provide his/her laboratory personnel with a copy of this SOP and a copy of the SDS provided by the manufacturer. I have read and understand the content of this SOP: Name Signature Initials Click here to enter text. Identification Date Click here to enter a date. 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