endocrine atul

OCTADECAFLUOROOCTANE

RTECS NUMBER : RG9701000

CHEMICAL NAME : Octane, octadecafluoro-

CAS REGISTRY NUMBER : 307-34-6

BEILSTEIN REFERENCE NO. : 1717142

REFERENCE : 4-01-00-00418 (Beilstein Handbook Reference)

LAST UPDATED : 199803

DATA ITEMS CITED : 2

MOLECULAR FORMULA : C8-F18

MOLECULAR WEIGHT : 438.08

SYNONYMS/TRADE NAMES :

* Eftop EF-L 100

* Octadecafluorooctane

* Perfluorooctane

* n-Perfluorooctane

*** HEALTH HAZARD DATA ***

** ACUTE TOXICITY DATA **

TYPE OF TEST : LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE : Intravenous

SPECIES OBSERVED : Rodent - mouse

DOSE/DURATION : 240 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

MIVRA6 Microvascular Research. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1968- Volume(issue)/page/year: 8,320,1974

*** STATUS IN U.S. ***

EPA TSCA Section 8(b) CHEMICAL INVENTORY

OCTADECANOL (1-)


CHEMICAL NAME : 1-Octadecanol






MOLECULAR FORMULA : C18-H38-O


WISWESSER LINE NOTATION : Q18

COMPOUND DESCRIPTOR : Tumorigen

Primary Irritant


* Adol 68

* Alfol 18

* Atalco S

* CO-1895

* CO-1897

* Crodacol-S

* Decyl octyl alcohol

* Dytol E-46

* Lorol 28

* Octadecanol

* n-Octadecanol

* Octadecyl alcohol

* n-Octadecyl alcohol

* Polaax

* Sipol S

* Siponol S

* Stearol

* Stearyl alcohol

* Steraffine

* USP XIII stearyl alcohol


** SKIN/EYE IRRITATION DATA **

TYPE OF TEST : Standard Draize test

ROUTE OF EXPOSURE : Administration onto the skin

SPECIES OBSERVED : Rodent - rabbit

DOSE/DURATION : 500 mg/24H

REACTION SEVERITY : Mild

REFERENCE :

JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,

Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.

Discontinued.

Volume(issue)/page/year: 4(5),1,1985


ROUTE OF EXPOSURE : Administration into the eye




REFERENCE :



Discontinued.




ROUTE OF EXPOSURE : Oral

SPECIES OBSERVED : Rodent - rat

DOSE/DURATION : 20 gm/kg

TOXIC EFFECTS :


REFERENCE :

37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed.,

Grayson,

M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978

Volume(issue)/page/year: 1,722,1978

** TUMORIGENIC DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE : Implant



TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Kidney, Ureter, Bladder - tumors

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

26,105,1966

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - 80705

No. of Facilities: 3948 (estimated)

No. of Industries: 37

No. of Occupations: 44

No. of Employees: 60590 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - 80705





No. of Female Employees: 181509 (estimated)



EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999

OCTADECYLAMINE


CHEMICAL NAME : Octadecylamine






MOLECULAR FORMULA : C18-H39-N


WISWESSER LINE NOTATION : Z18

COMPOUND DESCRIPTOR : Primary Irritant


* Adogenen 142

* Alamine 7

* Alamine 7D

* Amine AB

* 1-Aminooctadecane

* Armeen 18

* Armeen 18D

* Armofilm

* Crodamine 1.18D

* Farmin 80

* Kemamine P990

* Monooctadecylamine

* Nissan amine AB

* n-Octadecylamine

* 1-Octadecylamine

* Oktadecylamin

* Stearamine

* Stearylamine

* n-Stearylamine







REACTION SEVERITY : Moderate

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,

Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:

-,439,1986






TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O

Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-






TOXIC EFFECTS :


REFERENCE :





ROUTE OF EXPOSURE : Intraperitoneal



TOXIC EFFECTS :


REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161)

Formerly U.S. Clearinghouse for Scientific & Technical Information.

Volume(issue)/page/year: AD691-490

** OTHER MULTIPLE DOSE TOXICITY DATA **




DOSE/DURATION : 313 gm/kg/30W-C

TOXIC EFFECTS :

Related to Chronic Data - death

REFERENCE :



Discontinued.




















OCTADECYLTRIMETHYLAMMONIUM CHLORIDE

RTECS NUMBER : BT1750000

CHEMICAL NAME : Ammonium, trimethyloctadecyl-, chloride


OTHER CAS REGISTRY NOS. : 60976-70-7



MOLECULAR FORMULA : C21-H46-N.Cl


WISWESSER LINE NOTATION : 18K1&1&1 &Q &G


* Aliquat 7

* Arquad 18

* Arquad 18-50

* Cation AB

* Monostearyl trimethyl ammonium chloride

* Nissan cation AB

* Octadecyltrimethylammonium chloride

* Quaternium-10

* Stac

* Stearyltrimethylammonium chloride

* Trimethyloctadecylammonium chloride

* Trimethylstearylammonium chloride







TOXIC EFFECTS :


Behavioral - ataxia

Gastrointestinal - hypermotility, diarrhea

REFERENCE :

ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic

Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,

Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:

(103),37,1985





TOXIC EFFECTS :


Skin and Appendages - dermatitis, allergic (after systemic exposure)

Skin and Appendages - hair

REFERENCE :

ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic

Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,

Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year:

(103),37,1985

TYPE OF TEST : LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE : Unreported



TOXIC EFFECTS :


REFERENCE :

ATMPA2 Annals of Tropical Medicine and Parasitology. (Grune & Stratton,

Inc., POB 6280, Duluth, MN 55806) V.1- 1907-

Volume(issue)/page/year:

32,177,1938




OCTADIENE (1,7-)


CHEMICAL NAME : 1,7-Octadiene






MOLECULAR FORMULA : C8-H14


WISWESSER LINE NOTATION : 1U6U1






DOSE/DURATION : 19700 uL/kg

TOXIC EFFECTS :


REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf

Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:

30,470,1969

TYPE OF TEST : LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE : Inhalation


DOSE/DURATION : 8000 ppm/4H

TOXIC EFFECTS :


REFERENCE :



30,470,1969





TOXIC EFFECTS :


REFERENCE :



30,470,1969



OCTANE


CHEMICAL NAME : Octane




MOLECULAR FORMULA : C8-H18


WISWESSER LINE NOTATION : 8H


* n-Octane

* Octane

* Oktan

* Oktanen

* Ottani



TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill



DOSE/DURATION : 118 gm/m3/4H

TOXIC EFFECTS :


REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and

Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)

V.1-36, 1957-1992. For publisher information, see MTPEEI






TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :

APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)

V.1-59,

1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:

37,56,1975





DOSE/DURATION : 5 mg/kg/7D-I

TOXIC EFFECTS :

Liver - changes in liver weight

Biochemical - Enzyme inhibition, induction, or change in blood or tissue

levels - phosphatases


levels - other oxidoreductases

REFERENCE :

ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,

Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 22,271,1980

*** REVIEWS ***

ACGIH TLV-STEL 1750 mg/m3 (375 ppm)

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices

(BEIs) booklet issues by American Conference of Governmental Industrial

Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:

TLV/BEI,1997

ACGIH TLV-TWA 1400 mg/m3 (300 ppm)




TLV/BEI,1997

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD-air:TWA 400 ppm (1900 mg/m3)




3,191,1971

OSHA PEL (Gen Indu):8H TWA 500 ppm (2350 mg/m3)

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,

Supt.

of Documents, Washington, DC 20402) Volume(issue)/page/year:

29,1910.1000,1994

OSHA PEL (Construc):8H TWA 400 ppm (1900 mg/m3)


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 400 ppm (1900 mg/m3)


Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 500 ppm (2350 mg/m3)


Supt.


41,50-204.50,1994

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-AUSTRALIA:TWA 300 ppm (1450 mg/m3);STEL 375 ppm (1800 mg/m3) JAN 1993

OEL-AUSTRIA: MAK 300 ppm (1400 mg/m3), JAN1999

OEL-BELGIUM:TWA 300 ppm (1400 mg/m3);STEL 375 ppm (1750 mg/m3) JAN 1993

OEL-DENMARK: TWA 200 ppm (935 mg/m3), JAN1999

OEL-FINLAND:TWA 300 ppm (1400 mg/m3);STEL 375 ppm (1750 mg/m3) JAN 1993

OEL-GERMANY:TWA 500 ppm (2350 mg/m3) JAN 1993

OEL-HUNGARY:TWA 500 mg/m3;STEL 1500 mg/m3 JAN 1993

OEL-JAPAN:TWA 300 ppm (1400 mg/m3) JAN 1993

OEL-THE NETHERLANDS:TWA 300 ppm (1450 mg/m3) JAN 1993

OEL-POLAND: MAC(TWA) 1000 mg/m3, MAC(STEL) 1800 mg/m3, JAN1999

OEL-THE PHILIPPINES:TWA 500 ppm (2350 mg/m3) JAN 1993

OEL-RUSSIA:TWA 300 ppm JAN 1993

OEL-SWEDEN:TWA 200 ppm (900 mg/m3);STEL 300 ppm (1400 mg/m3) JAN 1993

OEL-SWITZERLAND:TWA 300 ppm (1400 mg/m3);STEL 600 ppm JAN 1993

OEL-TURKEY:TWA 400 ppm (1900 mg/m3) JAN 1993

OEL-UNITED KINGDOM:TWA 300 ppm (1450 mg/m3);STEL 375 ppm JAN 1993

OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV

OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV


NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :

NIOSH REL TO OCTANE-air:10H TWA 75 ppm;CL 385 ppm/15M

REFERENCE :

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of

Health, Education, and Welfare, Reports and Memoranda.

Volume(issue)/page/year: DHHS #92-100,1992

















EPA TSCA Section 8(d) unpublished health/safety studies


NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500

NIOSH Analytical Method, 1996: Volatile organic compound, 2549

OCTANOIC ACID

RTECS NUMBER : RH0175000

CHEMICAL NAME : Octanoic acid






MOLECULAR FORMULA : C8-H16-O2


WISWESSER LINE NOTATION : QV7

COMPOUND DESCRIPTOR : Mutagen

Primary Irritant


* Hexacid 898

* C-8 acid

* Caprylic acid

* n-Caprylic acid

* neo-Fat 8

* 1-Heptanecarboxylic acid

* Kyselina kaprylova

* Octic acid

* n-Octoic acid

* n-Octylic acid








REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.

For

publisher information, see FCTOD7. Volume(issue)/page/year: 19,237,1981






TOXIC EFFECTS :



REFERENCE :


For






TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

REFERENCE :


V.1-59,


18,141,1961




DOSE/DURATION : >5 gm/kg

TOXIC EFFECTS :


REFERENCE :


For


** MUTATION DATA **

TYPE OF TEST : Sex chromosome loss and nondisjunction

TEST SYSTEM : Yeast - Saccharomyces cerevisiae

DOSE/DURATION : 5 ppm

REFERENCE :

ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of

Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-


TYPE OF TEST : Mutation test systems - not otherwise specified

TEST SYSTEM : Non-mammalian species Cells - not otherwise specified

DOSE/DURATION : 10 mmol/L

REFERENCE :

CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44

Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:

40,1,1973

TYPE OF TEST : Cytogenetic analysis

TEST SYSTEM : Non-mammalian species Cells - not otherwise specified


REFERENCE :

CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44


40,1,1973

*** REVIEWS ***

TOXICOLOGY REVIEW

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,

1955-60.

For publisher information, see AEHLAU. Volume(issue)/page/year:

21,100,1960




















OCTANOL (1-)


CHEMICAL NAME : Octyl alcohol






WISWESSER LINE NOTATION : Q8


Natural Product

Primary Irritant


* Alcohol C-8

* Alfol 8

* Caprylic alcohol

* Dytol M-83

* EPAL 8

* Heptyl carbinol

* 1-Hydroxyoctane

* Lorol 20

* n-Octanol

* 1-Octanol

* Octilin

* Octyl alcohol, normal-primary

* n-Octyl alcohol

* Primary octyl alcohol

* Sipol L8








REFERENCE :


For






DOSE/DURATION : >3200 mg/kg

TOXIC EFFECTS :


REFERENCE :


For





DOSE/DURATION : 5600 mg/m3/4H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea

or bronchi

Lungs, Thorax, or Respiration - chronic pulmonary edema

Blood - hemorrhage

REFERENCE :

EPASR* United States Environmental Protection Agency, Office of

Pesticides

and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,

SW,

Washington, DC 20460) History unknown. Volume(issue)/page/year:

8EHQ-1088-0762





TOXIC EFFECTS :


REFERENCE :

HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.

(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:

31(1-3),310,1966





TOXIC EFFECTS :


REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.

(Heymans

Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-

1898- Volume(issue)/page/year: 135,330,1962



SPECIES OBSERVED : Rodent - guinea pig


TOXIC EFFECTS :


REFERENCE :


For



ROUTE OF EXPOSURE : Parenteral

SPECIES OBSERVED : Amphibian - frog


TOXIC EFFECTS :

Peripheral Nerve and Sensation - spastic paralysis with or without sensory

change


REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.

(Heymans

Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-




SPECIES OBSERVED : Mammal - species unspecified


TOXIC EFFECTS :


REFERENCE :




** MUTATION DATA **

TYPE OF TEST : Sex chromosome loss and nondisjunction

TEST SYSTEM : Rodent - hamster Lung

DOSE/DURATION : 800 umol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE

Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year:

182,135,1987


EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of

Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:

54,7740,1989


OEL-RUSSIA:STEL 10 mg/m3 JAN 1993




















OCTANOL (2-)


CHEMICAL NAME : 2-Octanol







* Capryl alcohol





SPECIES OBSERVED : Mammal - species unspecified


TOXIC EFFECTS :


REFERENCE :























OCTANONE (2-)


CHEMICAL NAME : 2-Octanone








WISWESSER LINE NOTATION : 6V1

COMPOUND DESCRIPTOR : Drug

Reproductive Effector

Primary Irritant


* Hexyl methyl ketone

* n-Hexyl methyl ketone

* Methyl hexyl ketone

* 2-Oxooctane








REFERENCE :


For







TOXIC EFFECTS :


REFERENCE :

KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)

Volume(issue)/page/year: #901875




DOSE/DURATION : >2132 ppm/6H

TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,

Clayton,

G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.

Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.

Volume(issue)/page/year: 2C,4765,1982





TOXIC EFFECTS :


REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE


30,13,1986





TOXIC EFFECTS :


REFERENCE :

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed.,

Clayton,

G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.

Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.

Volume(issue)/page/year: 2C,4765,1982





TOXIC EFFECTS :


REFERENCE :

JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,

Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,

DC

20037) V.6- 1963- Volume(issue)/page/year: 19,1257,1976





TOXIC EFFECTS :


REFERENCE :



** REPRODUCTIVE DATA **




DOSE : 1 gm/kg

SEX/DURATION : female 1-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant

per # sperm positive females; # females pregnant per # females mated)

REFERENCE :

JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,

Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,

DC



OEL-RUSSIA:STEL 200 mg/m3 JAN 1993




NOES Hazard Code - X5067










OCTANOYL CHLORIDE


CHEMICAL NAME : Octanoyl chloride






MOLECULAR FORMULA : C8-H15-Cl-O




* Caprylic acid chloride

* Capryloyl chloride

* Caprylyl chloride

* Octanoic acid chloride

* Octanoic chloride


** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Salmonella typhimurium

DOSE/DURATION : 666 ug/plate

REFERENCE :

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41

E.

11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:

19(Suppl 21),2,1992



OCTOPAMINE HYDROCHLORIDE

RTECS NUMBER : DN7365000

CHEMICAL NAME : Benzyl alcohol, alpha-(aminomethyl)-p-hydroxy-,

hydrochloride




MOLECULAR FORMULA : C8-H11-N-O2.Cl-H


WISWESSER LINE NOTATION : Z1YQR DQ &GH



* Benzenemethanol, alpha-(aminomethyl)-4-hydroxy-, hydrochloride

* 1-(4-Hydroxyphenyl)-2-aminoethanol hydrochloride

* Octopamine hydrochloride







TOXIC EFFECTS :


REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,

Japan) Volume(issue)/page/year: 6,159,1982





TOXIC EFFECTS :


Behavioral - tremor

Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :

YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,

Tokyo,

Japan) V.1- 1950- Volume(issue)/page/year: 25,1083,1974


ROUTE OF EXPOSURE : Subcutaneous



TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :


Tokyo,






TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :


Tokyo,






TOXIC EFFECTS :


Behavioral - tremor


REFERENCE :


Tokyo,






DOSE/DURATION : 24 gm/kg/30D-I

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes

Nutritional and Gross Metabolic - weight loss or decreased weight gain


REFERENCE :


Tokyo,





DOSE/DURATION : 72800 mg/kg/26W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - other changes


REFERENCE :


Tokyo,





DOSE/DURATION : 6 gm/kg/30D-I

TOXIC EFFECTS :

Brain and Coverings - other degenerative changes



REFERENCE :


Tokyo,






TOXIC EFFECTS :



REFERENCE :


Tokyo,


OCTYL ALDEHYDE


CHEMICAL NAME : 1-Octanal








WISWESSER LINE NOTATION : VH7

COMPOUND DESCRIPTOR : Natural Product

Primary Irritant


* Aldehyde C-8

* C-8 aldehyde

* Caprylic aldehyde

* Octanal

* Octanaldehyde

* n-Octyl aldehyde








REFERENCE :


For





DOSE/DURATION : 100 mg


REFERENCE :


For















OCTYLAMINE


CHEMICAL NAME : 1-Octanamine






MOLECULAR FORMULA : C8-H19-N


WISWESSER LINE NOTATION : Z8



* 1-Aminooctane

* Armeen 8

* Armeen 8D

* Caprylamine

* Caprylylamine

* Octylamine

* n-Octylamine







REACTION SEVERITY : Severe

REFERENCE :


Pesticides


SW,


8EHQ-1085-0569






TOXIC EFFECTS :


REFERENCE :


Pesticides


SW,


8EHQ-1085-0569





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)

V.1-33, 1946-68. For publisher information, see BJPCBM.






TOXIC EFFECTS :



REFERENCE :


Pesticides


SW,


8EHQ-1085-0569




NOHS Hazard Code - M3277









OCTYLPHENOL (TERT,4-)

RTECS NUMBER : SM9625000

CHEMICAL NAME : Phenol, p-(1,1,3,3-tetramethylbutyl)-








WISWESSER LINE NOTATION : QR DX1&1&1X1&1&1



Primary Irritant


* p-tert-Octylphenol

* p-terc.Oktylfenol

* Phenol, p-(tert-octyl)-

* 4-(1,1,3,3-Tetramethylbutyl)phenol








REFERENCE :



-,228,1986




DOSE/DURATION : 50 ug/24H


REFERENCE :



-,228,1986






TOXIC EFFECTS :



Liver - other changes

REFERENCE :

KCRZAE Kauchuk i Rezina. Crude and Vulcanized Rubber. (V/O

Mezhdunarodnaya

Kniga, 113095 Moscow, USSR) V.11- 1937- Volume(issue)/page/year:

26(9),28,1967





TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay)



REFERENCE :

KCRZAE Kauchuk i Rezina. Crude and Vulcanized Rubber. (V/O

Mezhdunarodnaya

Kniga, 113095 Moscow, USSR) V.11- 1937- Volume(issue)/page/year:

26(9),28,1967





TOXIC EFFECTS :


REFERENCE :



Volume(issue)/page/year: OTS0527972






TOXIC EFFECTS :


REFERENCE :



Volume(issue)/page/year: OTS0527972






TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Skin and Appendages - tumors

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:

19,413,1959





DOSE : 14 ug/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - delayed effects

REFERENCE :

TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co.,

POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year:

14,239,1998




DOSE : 140 ug/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - delayed effects

REFERENCE :



14,239,1998














OKADAIC ACID

RTECS NUMBER : AA8227800

CHEMICAL NAME : Acanthifolicin, 9,10-deepithio-9,10-didehydro-







Mutagen

Natural Product


* 9,10-Deepithio-9,10-didehydroacanthifolicin

* Okadaic acid






DOSE/DURATION : 192 ug/kg

TOXIC EFFECTS :


REFERENCE :

JACSAT Journal of the American Chemical Society. (American Chemical

Soc.,

Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC







TOXIC EFFECTS :



REFERENCE :

JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV,

POB

211, 1000 AE Amsterdam, Netherlands) V.76- 1985-


** MUTATION DATA **

TYPE OF TEST : Sister chromatid exchange

TEST SYSTEM : Human Lymphocyte


REFERENCE :



289,275,1993


TEST SYSTEM : Human Ovary


REFERENCE :



289,275,1993

TYPE OF TEST : Mutation in mammalian somatic cells


DOSE/DURATION : 10 ug/L

REFERENCE :



250,375,1991

OLEIC ACID


CHEMICAL NAME : 9-Octadecenoic acid, (Z)-








WISWESSER LINE NOTATION : QV8U9 -C


Mutagen

Primary Irritant


* Acide oleique

* Emersol 210

* Emersol 213

* Emersol 6321

* Emersol 233LL

* Emersol 221 low titer white oleic acid

* Emersol 220 white oleic acid

* Glycon RO

* Glycon WO

* Groco 2

* Groco 4

* Groco 6

* Groco 5L

* HY-Phi 1055

* HY-Phi 1088

* HY-Phi 2066

* HY-Phi 2088

* HY-Phi 2102

* Industrene 105

* Industrene 205

* Industrene 206

* cis-delta(sup 9)-Octadecenoic acid

* cis-Octadec-9-enoic acid

* cis-9-Octadecenoic acid

* 9-Octadecenoic acid, cis-

* Oleic acid

* Oleinic acid

* Pamolyn

* Tego-oleic 130

* Vopcolene 27

* Wecoline OO

* Wochem No. 320





SPECIES OBSERVED : Human

DOSE/DURATION : 15 mg/3D (Intermittent)


REFERENCE :

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"

Drill,

V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977

Volume(issue)/page/year: -,127,1977

TYPE OF TEST : Open irritation test





REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury

Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/29/1963






REFERENCE :



Discontinued.







TOXIC EFFECTS :


REFERENCE :

UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury

Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/29/1963





TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema


REFERENCE :

AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal

Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1-

1925-






TOXIC EFFECTS :


REFERENCE :

YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,

2-12-15

Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-






TOXIC EFFECTS :


REFERENCE :


V.1-59,


18,141,1961






TOXIC EFFECTS :


Tumorigenic - tumors at site of application

REFERENCE :

CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses

Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-


** MUTATION DATA **


TEST SYSTEM : Yeast - Saccharomyces cerevisiae

DOSE/DURATION : 100 mg/L

REFERENCE :

NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ

08736)

V.1- 1869- Volume(issue)/page/year: 294,263,1981

TYPE OF TEST : Unscheduled DNA synthesis

ROUTE OF EXPOSURE : Rectal

TEST SYSTEM : Rodent - mouse


REFERENCE :

CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.

Ireland

Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:

23,253,1984


TEST SYSTEM : Rodent - hamster Fibroblast


REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,

Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-






54,7740,1989




















OLEIC ACID SODIUM

RTECS NUMBER : RK1200000

CHEMICAL NAME : Oleic acid, sodium salt




MOLECULAR FORMULA : C18-H33-O2.Na


WISWESSER LINE NOTATION : QV8U9 &-NA-


Human


* Eunatrol

* Olate flakes

* Sodium oleate





SPECIES OBSERVED : Human - woman


TOXIC EFFECTS :

Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)

Lungs, Thorax, or Respiration - respiratory obstruction

REFERENCE :

JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270

Madison Ave., New York, NY 10016) V.19- 1982-


36,587,1998





TOXIC EFFECTS :


REFERENCE :

RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry.

(New

York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:

2,327,1970





TOXIC EFFECTS :


REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams

&

Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-






54,7740,1989










NOES Hazard Code - M0760








OLIVE OIL

RTECS NUMBER : RK4300000

CHEMICAL NAME : Olive oil





Natural Product

Primary Irritant






DOSE/DURATION : 300 mg/3D (Intermittent)


REFERENCE :

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"

Drill,

V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977

Volume(issue)/page/year: -,127,1977



SPECIES OBSERVED : Human - man



REFERENCE :

CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,

IL

60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979






REFERENCE :


IL







REFERENCE :


IL







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

KEKHB8 Kanagawa-ken Eisei Kenkyusho Kenkyu Hokoku. Bulletin of Kanagawa

Prefectural Public Health Laboratories. (Kanagawa-ken Eisei Kenkyusho,

52-2, Nakao-cho, Asahi-ku, Yokohama 241, Japan) No.1- 1971-

Volume(issue)/page/year: (3),19,1973

















EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; E coli polA

with S9




OMEPRAZOLE

RTECS NUMBER : DD9087000

CHEMICAL NAME : 1H-Benzimidazole,

5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)met

hyl)sulfinyl)-




MOLECULAR FORMULA : C17-H19-N3-O3-S



Mutagen


Human


* Antra

* Audazol

* AULCER

* Belmazol

* Ceprandal

* Elgam

* Emeproton

* Gastrimut

* H 168/68

* Indurgan

* Losec

*

5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimid

azole

* Miol

* Mopral

* Omapren

* Omepral

* Omeprazole

* Ompanyt

* Parizac

* Pepticum

* Prilosec

* Prysma

* Sanamidol

* Secrepina

* Ulceral

* Ulcsep

* Ulcometion

* Zimor






DOSE/DURATION : 4400 ug/kg/11D-I

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), diffuse

Liver - jaundice, other or unclassified

Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :

AJGAAR American Journal of Gastroenterology. (American College of

Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21-






TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,

acute tubular necrosis)

Blood - normocytic anemia

Nutritional and Gross Metabolic - body temperature increase

REFERENCE :

PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd.,

POB

88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 74,416,1998




DOSE/DURATION : 800 ug/kg/2D-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - pleural effusion

Lungs, Thorax, or Respiration - cough

Immunological Including Allergic - other immediate (humoral): urticaria,

allergic rhinitis, serum sickness

REFERENCE :

PHPYDQ Pharmacotherapy (Carlisle, MA). (Pharmacotherapy Pub., Inc., 112

School St., Carlisle, MA 01741) V.1- 1981- Volume(issue)/page/year:

14,119,1993





TOXIC EFFECTS :

Blood - eosinophilia

Kidney, Ureter, Bladder - interstitial nephritis

Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :

AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave.,

New

York, NY 10022) V.1- 1946- Volume(issue)/page/year: 95,248,1993





TOXIC EFFECTS :

Musculoskeletal - joints

Biochemical - Metabolism (Intermediary) - effect on inflammation or

mediation of inflammation

REFERENCE :

LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-






TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - ptosis

Behavioral - changes in motor activity (specific assay)

Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,

Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 36,369,1988





TOXIC EFFECTS :



Lungs, Thorax, or Respiration - dyspnea

REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :







TOXIC EFFECTS :



Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :







TOXIC EFFECTS :




REFERENCE :







TOXIC EFFECTS :


REFERENCE :

SJGSB8 Scandinavian Journal of Gastroenterology, Supplement. (Columbia

University Press, POB 258, Irvington-on-Hudson, NY 10533) No.1- 1968-






DOSE : 8320 mg/kg


lactating female 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight

gain)

REFERENCE :






DOSE : 3520 mg/kg


TOXIC EFFECTS :


REFERENCE :



** MUTATION DATA **

TYPE OF TEST : DNA damage


TEST SYSTEM : Rodent - rat


REFERENCE :



368,1,1996





REFERENCE :



262,73,1991

ORANGE G SODIUM

RTECS NUMBER : QJ6500000

CHEMICAL NAME : 1,3-Naphthalenedisulfonic acid,

7-hydroxy-8-(phenylazo)-, disodium salt




MOLECULAR FORMULA : C16-H10-N2-O7-S2.2Na



Mutagen



* Acidal Fast Orange

* Acid Fast Orange EGG

* Acid Fast Orange G

* Acid Leather Orange KG

* Acid Leather Orange PGW

* Acid Light Orange G

* Acid Light Orange J

* Acid Light Orange JA Export

* Acid Light Orange SX

* Acid Orange 10

* Acid Orange G

* Acid Orange 2G

* Acid Orange GG

* Acilan Orange GX

* Apocid Orange 2G

* Atul Acid Crystal Orange G

* Brasilan Orange 2G

* Bucacid Fast Orange G

* Calcocid Fast Light Orange 2G

* Certicol Orange GS

* Cetil Light Orange GG

* C.I. 27

* C.I. 16230

* C.I. Acid Orange 10

* C.I. Acid Orange 10, disodium salt

* C.I. Food Orange 4

* Colacid Orange G

* Crystal Orange 2G

* D&C Orange No. 3

* Eniacid Light Orange G

* Erio Fast Orange AS

* Fast Light Orange GA

* Fast Light Orange GA-CF

* Hexacol Orange GG Crystals

* Hidacid Fast Orange G

* Hidacid Fast Orange 2G

* Hispacid Fast Orange 2G

* 7-Hydroxy-8-(phenylazo)-1,3-naphthalenedisulfonic acid, disodium salt

* 7-Hydroxy-8-(phenylazo)-1,3-naphthalenedisulphonic acid, disodium salt

* Java Orange 2G

* Kiton Fast Orange G

* Ink Orange JSN

* Intracid Fast Orange G

* Naphthalene Fast Orange 2G

* Naphthalene Fast Orange 2GS

* Naphthalene Orange Solide GG

* NCI-C53838

* Neklacid Fast Light Orange GG

* Neklacid Fast Orange 2G

* Orange #10

* 1370 Orange

* Orange BPC

* Orange 2G

* Orange G (biological stain)

* Orange G BPC

* Orange G DYE

* Orange GG

* Orange G (indicator)

* Orange GMP

* Oranz G

* Oranz GG

* Oranz kysela 10

* Oranz potravinarska 4

* 1-Phenylazo-2-naphthol-6,8-disulfonic acid, disodium salt

* 1-Phenylazo-2-naphthol-6,8-disulphonic acid, disodium salt

* Schultz No. 39

* Solar Light Orange GX

* Standacol Orange G

* Straight Orange G

* Sulfacid Light Orange J

* Tertracid Light Orange G

* Unitertracid Light Orange G

* Vondacid Light Orange 2G

* Wool Orange G

* Wool Orange 2G

* Xylene Fast Orange G






DOSE/DURATION : 26250 mg/kg/15W-C

TOXIC EFFECTS :

Liver - changes in liver weight

Endocrine - changes in spleen weight


REFERENCE :


For






TOXIC EFFECTS :

Blood - changes in spleen

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research

Triangle Park, NC 27709) No.206- Volume(issue)/page/year:

NTP-TR-211,1987





TOXIC EFFECTS :

Blood - changes in spleen

REFERENCE :



NTP-TR-211,1987



SPECIES OBSERVED : Mammal - pig


TOXIC EFFECTS :

Endocrine - changes in spleen weight


Blood - other changes

REFERENCE :


For





SPECIES OBSERVED : Mammal - pig

DOSE : 28 gm/kg

SEX/DURATION : male 16 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :


For


** MUTATION DATA **

TYPE OF TEST : Phage inhibition capacity

TEST SYSTEM : Bacteria - Escherichia coli


REFERENCE :

MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see

EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-


TYPE OF TEST : Specific locus test

TEST SYSTEM : Rodent - mouse Lymphocyte

DOSE/DURATION : 1 gm/L

REFERENCE :


E.


17,196,1991


TEST SYSTEM : Rodent - hamster Ovary


REFERENCE :


E.


14,165,1989



DOSE/DURATION : 20 umol/L/5H (Continuous)

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For

publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979

*** REVIEWS ***

IARC Cancer Review:Animal Inadequate Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)


IARC Cancer Review:Human No Adequate Data

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of

Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY

12210)


IARC Cancer Review:Group 3

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979-


7,56,1987

















EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine

reversion-Ames test


NTP Carcinogenesis Studies (feed);no evidence:mouse,rat



NTP-TR-211,1987

ORANGE II

RTECS NUMBER : DB7084000

CHEMICAL NAME : Benzenesulfonic acid,

4-((2-hydroxy-1-naphthalenyl)azo)-, monosodium salt


OTHER CAS REGISTRY NOS. : 75025-97-7



MOLECULAR FORMULA : C16-H12-N2-O4-S.Na





* Acid Leather Orange Extra

* Acid Leather Orange Extra G

* Acid Leather Orange Extra PRW

* Acid Orange

* Acid Orange 7

* Acid Orange A

* Acid Orange II

* Acilan Orange II

* Airedale Orange II

* Amacid Orange Y

* Atul Acid Orange II

* Betanaphthol Orange

* Brasilan Orange A

* Bucacid Orange A

* Calcocid Orange Y

* Certiqual Orange II

* C.I. 15510

* C.I. Acid Orange 7

* C.I. Acid Orange 7, monosodium salt

* Colacid Orange

* Curol Orange

* D and C Orange No. 4

* Diacid Orange II

* Erio Orange II

* Fenazo Orange

* Hidacid Orange II

* Hispacid Orange AF

* p-((2-Hydroxy-1-naphthyl)azo)benzenesulfonic acid sodium salt

* Java Orange II

* Kiton Orange II

* Kromon Lake Orange Toner

* Lake Orange A

* Lake Orange II YS

* Leather Orange Extra

* Lurazol Orange E

* Lutetia Orange 3JR

* Mandarin G

* Naphthalene Lake Orange G

* Naphthalene Orange G

* Naphthol Orange

* beta-Naphthol orange

* 2-Naphthol Orange II

* beta-Naphthyl orange

* Naphtocard Orange II

* Neklacid Orange II

* No. 177 Orange Lake

* Nubilon Orange R

* 11550 Orange

* Orange Extra N

* Orange Extra P

* Orange II

* Orange IIC

* Orange II For Lakes

* Orange IIP

* Orange IIS

* Orange Iism

* Orange II Special For Lacquer

* Orange No. 205

* Orange 2 sodium salt

* Orange Toner GRT

* Orange Y

* Orange YA

* Orange YZ

* Oranz kysela 7

* Peeracid Orange II

* Perca Orange GR

* Persian Orange

* Persian Orange Lake

* Persian Orange X

* Pure Orange II S

* Rifa Acid Orange II

* Sanyo Gum Orange A

* Solar Orange

* Special Orange GR

* Special Orange H

* Symuler Orange Lake 43

* Symulon Acid Orange II

* Tangarine Lake X-917

* Tertracid Orange II

* Tropaeolin ooo

* Tropaeolin ooo 2

* Vondacid Orange II

* Wool Orange A







TOXIC EFFECTS :


Blood - pigmented or nucleated red blood cells

Blood - changes in erythrocyte (RBC) count

REFERENCE :

IJEBA6 Indian Journal of Experimental Biology. (Publications &

Information

Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-






TOXIC EFFECTS :


Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :



8,63,1992





DOSE : 150 gm/kg

SEX/DURATION : male 43 week(s) pre-mating

TOXIC EFFECTS :


REFERENCE :


Information




ROUTE OF EXPOSURE : Intratesticular


DOSE : 10 mg/kg

SEX/DURATION : male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,

sperm morphology, motility, and count)


REFERENCE :


Information



** MUTATION DATA **



DOSE/DURATION : 12 nmol/L

REFERENCE :



249,265,1991

















EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine

reversion-Ames test



ORNITHINE HYDROCHLORIDE (L-)

RTECS NUMBER : RM2985000

CHEMICAL NAME : Ornithine, monohydrochloride, L-




MOLECULAR FORMULA : C5-H12-N2-O2.Cl-H


WISWESSER LINE NOTATION : Z3YZVQ &GH -L



* L-Ornithine hydrochloride

* L-Ornithine monohydrochloride







TOXIC EFFECTS :


Behavioral - ataxia


REFERENCE :

JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical

Assoc.,

2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-













OROTIC ACID ANHYDROUS

RTECS NUMBER : RM3180000

CHEMICAL NAME : Orotic acid




MOLECULAR FORMULA : C5-H4-N2-O4


WISWESSER LINE NOTATION : T6MVMVJ FVQ


Mutagen


* Animal galactose factor

* 6-Carboxyuracil

* Orodin

* Orotonin

* Orotsaure

* Oroturic

* Orotyl

* 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-

* 6-Uracilcarboxylic acid

* Whey factor







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :



** MUTATION DATA **



DOSE/DURATION : 1 gm/L

REFERENCE :

ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH,

Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-


TYPE OF TEST : Morphological transformation



DOSE/DURATION : 25200 mg/kg/6W

REFERENCE :




TYPE OF TEST : DNA inhibition



DOSE/DURATION : 14 gm/kg/14D (Continuous)

REFERENCE :





TEST SYSTEM : Rodent - rat Liver


REFERENCE :






OSMIUM

RTECS NUMBER : RN1100000

CHEMICAL NAME : Osmium




MOLECULAR FORMULA : Os


WISWESSER LINE NOTATION : OS


* Metallic osmium





SPECIES OBSERVED : Mammal - dog


TOXIC EFFECTS :



Gastrointestinal - nausea or vomiting

REFERENCE :

SMSJAR Scottish Medical and Surgical Journal. (Edinburgh, Scotland) For

publisher information, see SMDJAK. Volume(issue)/page/year: 26,131,1826












OSMIUM TETROXIDE


CHEMICAL NAME : Osmium tetroxide




MOLECULAR FORMULA : O4-Os


WISWESSER LINE NOTATION : OS O4


Mutagen


Human


* Osmic acid

* Osmium tetroxide

* RCRA waste number P087



TYPE OF TEST : TCLo - Lowest published toxic concentration



DOSE/DURATION : 133 ug/m3

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation

Sense Organs and Special Senses (Eye) - effect, not otherwise specified

Lungs, Thorax, or Respiration - structural or functional change in trachea

or bronchi

REFERENCE :

BJIMAG British Journal of Industrial Medicine. (British Medical Journal,

Box 560B, Kennebunkport, ME 04046) V.1- 1944-


3,183,1946





TOXIC EFFECTS :


REFERENCE :

SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon

Rd.,

San Romon, CA 94583) Volume(issue)/page/year: -,8,1961





TOXIC EFFECTS :


REFERENCE :


Rd.,






TOXIC EFFECTS :


REFERENCE :


Rd.,






TOXIC EFFECTS :


REFERENCE :


Rd.,






TOXIC EFFECTS :


REFERENCE :


Rd.,





DOSE/DURATION : 1316 mg/m3/30M

TOXIC EFFECTS :

Behavioral - coma


Kidney, Ureter, Bladder - other changes

REFERENCE :

JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35.

For

publisher information, see AEHLAU. Volume(issue)/page/year: 15,136,1933



ROUTE OF EXPOSURE : Intratesticular


DOSE : 20336 ug/kg


TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic

material,



REFERENCE :

JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book

Depot,

POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-





DOSE : 20336 ug/kg


TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,



REFERENCE :


Depot,



** MUTATION DATA **

TYPE OF TEST : DNA repair

TEST SYSTEM : Bacteria - Bacillus subtilis


REFERENCE :



77,109,1980


TEST SYSTEM : Rodent - hamster Embryo


REFERENCE :



131,173,1984

*** REVIEWS ***

ACGIH TLV-STEL 0.0047 mg/m3 (0.0006 ppm)




TLV/BEI,1997

ACGIH TLV-TWA 0.0016 mg/m3 (0.0002 ppm)




TLV/BEI,1997


MSHA STANDARD-air:TWA 0.002 mg/m3




3,192,1971

OSHA PEL (Gen Indu):8H TWA 0.002 mg(Os)/m3


Supt.


29,1910.1000,1994

OSHA PEL (Construc):8H TWA 0.002 mg(Os)/m3


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 0.002 mg(Os)/m3


Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 0.002 mg(Os)/m3


Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 0.0002 ppm (0.002 mg/m3) JAN 1993

OEL-AUSTRIA: MAK 0.0002 ppm (0.002 mg/m3), JAN1999

OEL-AUSTRALIA:TWA 0.0002 ppm (0.002 mg/m3);STEL 0.0006 ppm JAN 1993

OEL-BELGIUM:TWA 0.0002 ppm (0.0016 mg/m3);STEL 0.0006 ppm JAN 1993

OEL-DENMARK: TWA 0.0002 ppm (0.002 mg/m3), JAN1999

OEL-FINLAND:TWA 0.0002 mg/m3;STEL 0.002 mg/m3 JAN 1993

OEL-GERMANY:TWA 0.0002 ppm (0.002 mg/m3) JAN 1993

OEL-HUNGARY:TWA 0.002 mg/m3;STEL 0.003 mg/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 0.0002 ppm (0.002 mg/m3) JAN 1993

OEL-THE PHILIPPINES:TWA 0.002 mg/m3 JAN 1993

OEL-SWITZERLAND:TWA 0.0002 ppm (0.002 mg/m3);STEL 0.0004 ppm JAN 1993

OEL-UNITED KINGDOM:TWA 0.0002 ppm (0.002 mg/m3);STEL 0.0006 ppm (0.006

mg/m3) JAN 1993





NIOSH REL TO OSMIUM TETROXIDE-air:10H TWA 0.0002 ppm;STEL 0.0006 ppm

REFERENCE :



















EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal


On EPA IRIS database

OUABAIN


CHEMICAL NAME : Ouabain octahydrate




MOLECULAR FORMULA : C29-H44-O12.8H2-O


WISWESSER LINE NOTATION : L E5 B666TJ A1Q CQ E1 IQ MQ QQ F- DT5OV EHJ& OO-

BT6OTJ CQ DQ EQ F1 &QH 8








TOXIC EFFECTS :

Cardiac - arrhythmias (including changes in conduction)

REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :

JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland


39,161,1993

OXALIC ACID ANHYDROUS

RTECS NUMBER : RO2450000

CHEMICAL NAME : Oxalic acid








WISWESSER LINE NOTATION : QVVQ

COMPOUND DESCRIPTOR : Reproductive Effector

Human

Primary Irritant


* Acide oxalique

* Acido ossalico

* Aktisal

* Aquisal

* Ethanedioic acid

* Ethanedionic acid

* Kyselina stavelova

* NCI-C55209

* Oxaalzuur

* Oxalic acid

* Oxalsaeure








REFERENCE :



-,311,1986




DOSE/DURATION : 250 ug/24H


REFERENCE :



-,311,1986

TYPE OF TEST : Rinsed with water



DOSE/DURATION : 100 mg/4S


REFERENCE :

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell

House,

Fairview Park, Elmsford, NY 10523) V.20- 1982-


20,573,1982






TOXIC EFFECTS :

Gastrointestinal - changes in structure or function of esophagus


Gastrointestinal - other changes

REFERENCE :


Tokyo,






TOXIC EFFECTS :


REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:

42,417,1977





TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,

Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 62,203,1990





TOXIC EFFECTS :


REFERENCE :

HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."

(Leipzig,

Ger. Dem. Rep.) Volume(issue)/page/year: 4,1377,1935



SPECIES OBSERVED : Mammal - cat


TOXIC EFFECTS :


REFERENCE :


(Leipzig,




SPECIES OBSERVED : Amphibian - frog


TOXIC EFFECTS :


REFERENCE :


(Leipzig,






DOSE/DURATION : 175 gm/kg/70D-C

TOXIC EFFECTS :

Endocrine - changes in thyroid weight

Musculoskeletal - other changes


REFERENCE :



48,409,1979





DOSE : 8400 mg/kg


female 7 day(s) pre-mating - 21 day(s) after

conception

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

e.g., stunted fetus)

REFERENCE :



Volume(issue)/page/year: PB86-167053

*** REVIEWS ***

ACGIH TLV-STEL 2 mg/m3




TLV/BEI,1997

ACGIH TLV-TWA 1 mg/m3




TLV/BEI,1997

TOXICOLOGY REVIEW

FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub

lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973





54,7740,1989

MSHA STANDARD-air:TWA 1 mg/m3




3,193,1971

OSHA PEL (Gen Indu):8H TWA 1 mg/m3


Supt.


29,1910.1000,1994

OSHA PEL (Construc):8H TWA 1 mg/m3


Supt.


29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 1 mg/m3


Supt.


29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 1 mg/m3


Supt.


41,50-204.50,1994


OEL-ARAB Republic of Egypt:TWA 1 mg/m3 JAN 1993

OEL-AUSTRIA: MAK 1 mg/m3, JAN1999

OEL-AUSTRALIA:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993

OEL-BELGIUM:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993

OEL-DENMARK: TWA 1 mg/m3, JAN1999

OEL-FINLAND:TWA 1 mg/m3;STEL 3 mg/m3 JAN 1993

OEL-THE NETHERLANDS:TWA 1 mg/m3 JAN 1993

OEL-THE PHILIPPINES:TWA 1 mg/m3 JAN 1993

OEL-SWITZERLAND:TWA 1 mg/m3 JAN 1993

OEL-POLAND: MAC(TWA) 1 mg/m3, MAC(STEL) 2 mg/m3, JAN1999

OEL-UNITED KINGDOM:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993

OEL-SWEDEN: NGV 1 mg/m3, KTV 2 mg/m3, JAN1999





NIOSH REL TO OXALIC ACID-air:10H TWA 1 mg/m3;STEL 2 mg/m3

REFERENCE :





















OXALIC ACID DIAMIDE


CHEMICAL NAME : Oxamide






WISWESSER LINE NOTATION : ZVVZ



* Amid kyseliny stavelove

* Diaminoglyoxal

* Ethanediamide

* Formimidic acid, 1-carbamoyl-

* Oxalamide

* Oxalic acid diamide

* Oxamid

* Oxamimidic acid








REFERENCE :



-,339,1986


TYPE OF TEST : LD - Lethal dose




TOXIC EFFECTS :


REFERENCE :

NCNSA6 National Academy of Sciences, National Research Council,

Chemical-Biological Coordination Center, Review. (Washington, DC)




OXALIC ACID DIAMMONIUM


CHEMICAL NAME : Oxalic acid, diammonium salt




MOLECULAR FORMULA : C2-H2-O4.2H3-N



* Ammonium oxalate

* Ethanedioic acid diammonium salt





54,7740,1989


















OXALYL CHLORIDE

RTECS NUMBER : KI2950000

CHEMICAL NAME : Ethanedioyl dichloride






MOLECULAR FORMULA : C2-Cl2-O2



* Ethanedioyl chloride

* Oxalic acid chloride

* Oxalic acid dichloride

* Oxalic dichloride

* Oxaloyl chloride

* Oxalyl chloride

* Oxalyl dichloride







TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - corneal damage


Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :



56,74,1995



OXAZOLIDONE (2-)

RTECS NUMBER : RQ2450000

CHEMICAL NAME : 2-Oxazolidinone






MOLECULAR FORMULA : C3-H5-N-O2


WISWESSER LINE NOTATION : T5MVOTJ



* Carbamic acid, (2-hydroxyethyl)-, gamma-lactone

* Oxazolidone







TOXIC EFFECTS :



REFERENCE :

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,



2,168,1959





TOXIC EFFECTS :



REFERENCE :

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,



2,168,1959

OXIBENDAZOLE

RTECS NUMBER : FD0835000

CHEMICAL NAME : Carbamic acid, (5-propoxy-1H-benzimidazol-2-yl)-,

methyl ester






WISWESSER LINE NOTATION : T56 BM DNJ CMVO1 GO3


Mutagen



* 2-Benzimidazolecarbamic acid, 5-propoxy-, methyl ester

* Loditac

* Methyl 5-n-propoxy-2-benzimidazole carbamate

* OBDZ

* Oxibendazole

* 5-Propoxy-2-benzimidazolecarbamic acid methyl ester

* N-(Propoxy-5, benzimidazolyl)-2, carbamate de methyle

* N-(2-(5-Propoxybenzimidazolyl)) methyl carbamate

* SKF 30310







TOXIC EFFECTS :


REFERENCE :

AJVRAH American Journal of Veterinary Research. (American Veterinary

Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-






DOSE : 30 mg/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :







DOSE : 100 mg/kg


TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or

resorbed implants per total number of implants)

REFERENCE :







DOSE : 300 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - sex ratio

REFERENCE :







DOSE : 900 mg/kg


TOXIC EFFECTS :



REFERENCE :

RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year

Book

Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824-




SPECIES OBSERVED : Mammal - domestic

DOSE : 90 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :

RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year

Book

Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824-


** MUTATION DATA **


TEST SYSTEM : Human Leukocyte


REFERENCE :

THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,

France) V.1- 1946- Volume(issue)/page/year: 31,505,1976


TEST SYSTEM : Human Cells - not otherwise specified


REFERENCE :

THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,

France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

OXO TEMPO (4-)

RTECS NUMBER : TN9200000

CHEMICAL NAME : Piperidinooxy, 2,2,6,6-tetramethyl-4-oxo-









* Tempone

* 2,2,6,6-Tetramethyl-4-oxo-piperidin-1-oxyl


** MUTATION DATA **


TEST SYSTEM : Rodent - hamster Fibroblast


REFERENCE :

NTRSDC Nutrition Research. (Pergamon Press Inc., Maxwell House, Fairview

Park, Elmsford, NY 10523) V.1- 1981- Volume(issue)/page/year:

4,989,1984



OXOLINIC ACID

RTECS NUMBER : JI5075000

CHEMICAL NAME : 1,3-Dioxolo(4,5-g)quinoline-7-carboxylic acid,

5-ethyl-5,8-dihydro-8-oxo-







WISWESSER LINE NOTATION : T C566 DO FO JN MV EHJ J2 LVQ

COMPOUND DESCRIPTOR : Agricultural Chemical

Tumorigen

Drug

Mutagen


* Dioxacin

* Emyrenil

* 1-Ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylic acid

* 5-Ethyl-5,8-dihydro-8-oxo-1,3-dioxolo(4,5-g)quinoline-7-carboxylic acid

* 1-Ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylic acid

* Gramurin

* Nidantin

* NSC-110364

* Ossian

* Oxoboi

* Oxolinic acid

* Pietil

* Prodoxol

* S-0208

* Starner

* Uritrate

* Uro-alvar

* Urotrate

* Uroxol

* Ultibid

* W 4565







TOXIC EFFECTS :


REFERENCE :



18,185,1971





TOXIC EFFECTS :


REFERENCE :

JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc.,

1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For

publisher information, see AGJAEP. Volume(issue)/page/year: (55),21,1989





TOXIC EFFECTS :


REFERENCE :



18,185,1971





TOXIC EFFECTS :


REFERENCE :

USXXAM United States Patent Document. (U.S. Patent Office, Box 9,

Washington, DC 20231) Volume(issue)/page/year: #4292317





TOXIC EFFECTS :


REFERENCE :

AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)

1961-70. For publisher information, see AMACCQ.


-,475,1967



SPECIES OBSERVED : Rodent - hamster


TOXIC EFFECTS :


REFERENCE :

AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)

1961-70. For publisher information, see AMACCQ.


-,475,1967






TOXIC EFFECTS :

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)


levels - dehydrogenases


levels - other transferases

REFERENCE :

TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,

101479,

Russia) History Unknown Volume(issue)/page/year: (3),34,1997





DOSE/DURATION : 43800 mg/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria

Reproductive - Tumorigenic effects - testicular tumors

REFERENCE :

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell

House,



32,397,1994

** MUTATION DATA **

TYPE OF TEST : Mutation in microorganisms

TEST SYSTEM : Bacteria - Salmonella typhimurium


REFERENCE :



248,135,1991




REFERENCE :

AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for

Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972-





REFERENCE :







REFERENCE :

EJBCAI European Journal of Biochemistry. (Springer-Verlag New York,

Inc.,

Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967-





REFERENCE :



248,135,1991

TYPE OF TEST : DNA repair



REFERENCE :




TYPE OF TEST : DNA damage




REFERENCE :

MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,

Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:

3,397,1988




REFERENCE :



243,213,1990

OXYGEN

RTECS NUMBER : RS2060000

CHEMICAL NAME : Oxygen




MOLECULAR FORMULA : O2


WISWESSER LINE NOTATION : .O2



Human






DOSE/DURATION : 100 pph/14H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - cough


REFERENCE :

JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.

Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:

128,710,1945





DOSE : 12 pph/10M

SEX/DURATION : female 26-39 week(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - cardiovascular

(circulatory) system

REFERENCE :

AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,

11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-





DOSE : 10 pph/12H

SEX/DURATION : female 22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - respiratory system

REFERENCE :

AJPHAP American Journal of Physiology. (American Physiological Soc.,

9650

Rockville Pike, Bethesda, MD 20814) V.1- 1898-


257,L221,1989




DOSE : 10 pph/9H


TOXIC EFFECTS :


Reproductive - Effects on Newborn - physical

REFERENCE :

AJPHAP American Journal of Physiology. (American Physiological Soc.,

9650

Rockville Pike, Bethesda, MD 20814) V.1- 1898-


257,L221,1989




DOSE : 10 pph/24H


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - skin and skin

appendages

REFERENCE :

NDKIA2 Kankyo Igaku Kenkyusho Nenpo (Nagoya Daigaku). Annual Report of the

Research Institute of Environmental Medicine, Nagoya University. (Nagoya

Daigaku Kankyo Igaku Kenkyusho, Furo-cho, Chikosa-ku, Nagoya 464, Japan)


** MUTATION DATA **



DOSE/DURATION : 40 pph/4D

REFERENCE :

HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center,

44


74,438,1986



DOSE/DURATION : 20 pph/3D (Continuous)

REFERENCE :



219,17,1989



DOSE/DURATION : 80 pph

REFERENCE :



57,27,1978




REFERENCE :



219,17,1989



DOSE/DURATION : 95 pph/24H

REFERENCE :



57,27,1978


TEST SYSTEM : Bird - chicken Embryo


REFERENCE :

ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York,

NY


*** REVIEWS ***

TOXICOLOGY REVIEW

FEPRA7 Federation Proceedings, Federation of American Societies for

Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.


TOXICOLOGY REVIEW

CEFYAD Ceskoslovenska Fysiologie. (Academia, Vodickova 40, 112 29 Prague

1,

Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 23,513,1974

TOXICOLOGY REVIEW

PTPBD7 Pharmacology and Therapeutics, Part B: General and Systematic

Pharmacology. (Oxford, UK) V.1-3, 1975-78. For publisher information, see

PHTHDT. Volume(issue)/page/year: 1,731,1975

TOXICOLOGY REVIEW

32RWA4 "Free Radicals in Biology," Pryor, W.A., ed., V.1- , New York,

Academic Press, Inc., 1976- Volume(issue)/page/year: 1,239,1976

TOXICOLOGY REVIEW

ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,

2350

Virginia Ave., Hagerstown, MD 21740) V.1- 1940-


37,210,1972

















EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation




NIOSH Analytical Method, 1994: Oxygen, 6601

OXYLTETRAMETHYL PIPERIDINE (2,2,6,6-)

RTECS NUMBER : TN8991900

CHEMICAL NAME : Piperidinooxy, 2,2,6,6-tetramethyl-





MOLECULAR FORMULA : C9-H18-N-O




* 1-Piperidinyloxy, 2,2,6,6-tetramethyl-

* Tanan

* Tanane

* Tempo

* Tetramethylpiperidine nitroxide

* 2,2,6,6-Tetramethylpiperidine-1-oxyl

* Tetramethylpiperidinooxy

* 2,2,6,6-Tetramethylpiperidinooxy

* 2,2,6,6-Tetramethylpiperidinooxyl

* 2,2,6,6-Tetramethylpiperidinyloxy

* 2,2,6,6-Tetramethyl-1-piperidinyloxy

* 2,2,6,6-Tetramethylpiperidoxyl








REFERENCE :


Pesticides


SW,


8EHQ-0786-0607S






REFERENCE :


Pesticides


SW,


8EHQ-0786-0607S





DOSE/DURATION : 4500 mg/m3/2H

TOXIC EFFECTS :


REFERENCE :


Pesticides


SW,


8EHQ-0786-0607S





TOXIC EFFECTS :


REFERENCE :


Pesticides


SW,


8EHQ-0786-0607S



OXYTETRACYCLINE HYDROCHLORIDE

RTECS NUMBER : QI8225000

CHEMICAL NAME : 2-Naphthacenecarboxamide,

4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,

6,10,12,12a- hexahydroxy-6-methyl-1,11-dioxo-,

monohydrochloride




MOLECULAR FORMULA : C22-H24-N2-O9.Cl-H


WISWESSER LINE NOTATION : L E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 KQ

MQ

M1 RQ &GH


Drug

Mutagen


Human


* Aquacycline

* Biosolvomycin

* Engemycin

* Hydrocyclin

* 5-Hydroxytetracycline hydrochloride

* Liquamycin injectable

* Mepatar

* NSC 9169

* Otetryn

* Oxlopar

* Oxyject 100

* Oxytetracycline hydrochloride

* Oxytetrin

* Terramycin hydrochloride

* Tetran hydrochloride

* TM 5







TOXIC EFFECTS :


REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,

Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-






TOXIC EFFECTS :


REFERENCE :


&







TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :








TOXIC EFFECTS :


REFERENCE :

85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds.,

Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,490,1967





TOXIC EFFECTS :

Peripheral Nerve and Sensation - flaccid paralysis without anesthesia

(usually neuromuscular blockage)



REFERENCE :








TOXIC EFFECTS :

Behavioral - tremor


Behavioral - excitement

REFERENCE :


&







DOSE/DURATION : 1802 gm/kg/2Y

TOXIC EFFECTS :


Endocrine - tumors

REFERENCE :



NTP-TR-315,1987





DOSE : 20 mg/kg

SEX/DURATION : female 20 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

REFERENCE :

GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc.,

79

Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year:

26,177,1988




DOSE : 11250 mg/kg


TOXIC EFFECTS :





REFERENCE :







DOSE : 12 gm/kg


TOXIC EFFECTS :



REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.

First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,

see TOSCF2 Volume(issue)/page/year: 7,434,1986




DOSE : 21 gm/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :







DOSE : 900 mg/kg


TOXIC EFFECTS :

Reproductive - Effects on Newborn - viability index (e.g., # alive at day

4

per # born alive)


gain)

REFERENCE :

CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses

Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-


** MUTATION DATA **

TYPE OF TEST : DNA adduct



REFERENCE :

BIORAK Biochemistry (English Translation). Translation of BIOHAO.

(Plenum

Pub. Corp., 233 Spring St., New York, NY 10013) V.21- 1956-



TEST SYSTEM : Microorganism - not otherwise specified


REFERENCE :


(Plenum




TEST SYSTEM : Microorganism - not otherwise specified


REFERENCE :


(Plenum



TYPE OF TEST : Micronucleus test


TEST SYSTEM : Rodent - mouse

DOSE/DURATION : 100 mg/kg/24H (Intermittent)

REFERENCE :



117,193,1983

TYPE OF TEST : Specific locus test

TEST SYSTEM : Rodent - mouse Lymphocyte


REFERENCE :


E.


17,196,1991


TEST SYSTEM : Mammal - species unspecified Lymphocyte


REFERENCE :


(Plenum




TEST SYSTEM : Mammal - species unspecified Lymphocyte


REFERENCE :


(Plenum







54,7740,1989


















NTP Carcinogenesis Studies (feed);equivocal evidence:rat



NTP-TR-315,1987

NTP Carcinogenesis Studies (feed);no evidence:mouse



NTP-TR-315,1987

OXYTOCIN

RTECS NUMBER : RS7534000

CHEMICAL NAME : Oxytocin





MOLECULAR FORMULA : C43-H66-N12-O12-S2




Human

Hormone


* Atonin O

* Di-sipidin

* Endopituitrina

* alpha-Hypophamine

* Nobitocin S

* Orasthin

* Oxetakain

* Oxystin

* Partocon

* Pitocin

* Piton S

* Posterior pituitary extract

* Presoxin

* Synpitan

* Synthetic oxytocin

* Syntocin

* Syntocinon

* Syntocinone

* Utedrin

* Uteracon






DOSE/DURATION : >20520 ug/kg

TOXIC EFFECTS :


REFERENCE :


Japan) Volume(issue)/page/year: -,230,1990




DOSE/DURATION : >20520 ug/kg

TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







TOXIC EFFECTS :


REFERENCE :







DOSE : 82 ng/kg


TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - blood and lymphatic

systems (including spleen and marrow)

REFERENCE :

ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB

560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year:

54,400,1979




DOSE : 5760 uL/kg


TOXIC EFFECTS :


Reproductive - Specific Developmental Abnormalities - hepatobiliary system

Reproductive - Effects on Newborn - viability index (e.g., # alive at day

4

per # born alive)

REFERENCE :

PPATDQ Pediatric Pathology. (Hemisphere Publishing Corp., c/o Taylor &

Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1-

1983-





DOSE : 20 ug/kg


TOXIC EFFECTS :


gain)

REFERENCE :






DOSE : 650 ng/kg


TOXIC EFFECTS :

Reproductive - Maternal Effects - parturition

REFERENCE :






DOSE : 30000 iu/kg

SEX/DURATION : female 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders


REFERENCE :

ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E,

DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year:

125,109,1991




DOSE : 277 ng/kg


TOXIC EFFECTS :


REFERENCE :






DOSE : 10 units/kg


TOXIC EFFECTS :


REFERENCE :

JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland


23,27,1988




DOSE : 175 ug/kg


TOXIC EFFECTS :


Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-





DOSE : 175 ug/kg


lactating female 21 day(s) post-birth

TOXIC EFFECTS :


gain)

REFERENCE :

JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,

Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-





DOSE : 500 ug/kg


TOXIC EFFECTS :


gain)

Reproductive - Effects on Newborn - physical

REFERENCE :

NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell

House,



15,383,1993




DOSE : 500 ng/kg


TOXIC EFFECTS :


Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :






DOSE : 80 ug/kg


TOXIC EFFECTS :


REFERENCE :

BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd.,

Houndmills,

Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-


36,188P,1969




DOSE : 80 ug/kg


TOXIC EFFECTS :


REFERENCE :

BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd.,

Houndmills,

Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-


36,188P,1969




DOSE : 80 ug/kg


TOXIC EFFECTS :


REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine.

(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-

1903/04-



ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Primate - monkey

DOSE : 900 ug/kg


TOXIC EFFECTS :


REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)

V.1-





DOSE : 300 mg/kg


TOXIC EFFECTS :



REFERENCE :

CEFYAD Ceskoslovenska Fysiologie. (Academia, Vodickova 40, 112 29 Prague

1,

Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 38,278,1989




DOSE : 150 ng/kg


TOXIC EFFECTS :

Reproductive - Fertility - mating performance (e.g. # sperm positive females

per # females mated; # copulations per # estrus cycles)

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E.

Preston

St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:

73,433,1963




DOSE : 2400 ng/kg


TOXIC EFFECTS :


REFERENCE :

ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica,

Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948-




SPECIES OBSERVED : Rodent - hamster

DOSE : 24 ug/kg

SEX/DURATION : lactating female 1 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Maternal Effects - postpartum

REFERENCE :


Depot,





SPECIES OBSERVED : Mammal - domestic

DOSE : 1613 mg/kg

SEX/DURATION : female 18-19 week(s) after conception

TOXIC EFFECTS :


Reproductive - Effects on Embryo or Fetus - other effects to embryo

Reproductive - Specific Developmental Abnormalities - blood and lymphatic

systems (including spleen and marrow)

REFERENCE :

AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,

11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-



ROUTE OF EXPOSURE : Intramuscular

SPECIES OBSERVED : Mammal - cattle

DOSE : 50 ug/kg


TOXIC EFFECTS :


REFERENCE :

BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue,

Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year:

146,577,1990



SPECIES OBSERVED : Mammal - cattle

DOSE : 54 ng/kg


TOXIC EFFECTS :


Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :


Depot,












endocrine atul

Related documents

Products

Support

endocrine atul

Related documents

Add this document to collection(s)

Add this document to saved

Suggest us how to improve StudyLib