EDUCATIONAL ESTABLISHMENT “VITEBSK STATE ORDER OF PEOPLES’ FRIENDSHIP MEDICAL UNIVERSITY” DEPARTMENT OF PHTHISIOPULMONOLOGY «APPROVED» Vice-rector of Educational Work and Foreign Affairs, Professor _______________ N.Yu.Konevalova «___» June 2011 Reg.No.____________________ ________________________Phthisiopulmonology_______________________ (Name of a discipline) WORKING PROGRAM ____1-790101____ (Speciality code) General Medicine____________ (Name of a discipline) 2011 COMPOSERS: A.M.Budritsky, the Head of Phthisiopulmonology Department of VSMU, PhD, Associate Professor READERS: T.I.Dmitrachenko, the Head of Infectious Diseases Department of VSMU, ScD, Professor S.B.Volf, the Head of Department of Grodno State Medical University, PhD, Associate Professor RECOMMENDED TO BE APPROVED: By Phthisiopulmonology Department (Protocol № 15, dated 06.06.2011) Central Scientific-Methods Council of Educational Establishment “Vitebsk State Medical University” (Protocol № ___, dated «___» _______ 2011) Responsible for edition: A.M.Budritsky Responsible for publication: A.M.Budritsky 1 EXPLANATORY NOTE GOALS AND OBJECTIVES OF THE DISCIPLINE AND ITS PLACE IN EDUCATIONAL PROCESS The main purpose of the course “Phthisiopulmonology” is preparing of students in the field of tuberculosis as infectious disease and of another pulmonary pathology. The objectives of Phthisiopulmonology studying are defined in accordance with educational program: definition of the discipline subject; lighting epidemiology, microbiology, pathological anatomy, pathogenesis and immunology of tuberculosis at the present stage; study of the basic methods of radiation diagnosis, lung and blood circulation function, tuberculin and laboratory diagnosis of tuberculosis; study clinical forms of primary and secondary pulmonary tuberculosis including combined with dust related occupational lung diseases, diabetes, COPD, gastric ulcer and duodenal ulcer, alcoholism, mental illness, lung cancer and other diseases; study of basic principles and methods of treatment TB patients, including emergency care for acute complications and conditions in tuberculosis - hemoptysis, pulmonary hemorrhage, spontaneous pneumothorax; study of the structure, objectives, TB facilities and organization of their work on the prevention of tuberculosis. The list of preceding tuberculosis disciplines: Microbiology with Virology and Immunology, General and Clinical Pharmacology, Pathological Anatomy and Histology, Pathological Physiology, Radiological Diagnosis and Oncology, Neurology and Neurosurgery, Propedeutics of Internal Diseases, Internal Diseases /Pulmonology/; Social Hygiene, Organization of Management and Health Economics. 2 SAMPLE THEME PLAN XI-XII semester Number of classroom hours Name of theme 1. Epidemiology of tuberculosis in different countries. General principles for identification, diagnosis and treatment of TB patients in accordance with WHO recommendations Lecture Laboratory Lecture № 1, 2 hours PLAN of practical classes on Phthisiopulmonology for the 6-year overseas students of Overseas students Training Faculty Name of theme 1. Epidemiological situation of tuberculosis in different countries of the world. DOTS strategy. 2. Radiographic methods for diagnosis of tuberculosis. Solid and sampling methods of the population examination. 3. Early detection of tuberculosis in children by tuberculin diagnostics. Primary tuberculosis in children. 4. Secondary tuberculosis: focal, infiltrative, disseminated, tuberculosis pleurisy, tuberculous meningitis. Differential diagnosis. Treatment. Number of classroom hours Practical Lectures Practical class № 1, 6 hours Practical class № 2, 6 hours Practical class № 3, 6 hours Practical class № 4, 6 hours 3 5. The course and clinical manifestations of chronic and complicated forms of secondary pulmonary tuberculosis with collapse peculiarities. TB detection peculiarities in persons with high risk disease (COPD, diabetes, peptic ulcer disease, pneumoconiosis, chronic alcoholism, pregnancy, AIDS). 6. Emergency care for complications of tuberculosis. Basic principles of treatment and chemotherapy of patients with pulmonary tuberculosis in the WHO recommendations. Selection of persons for surgical treatment. 7. Working in dispensary department. Outpatient reception of patients. Methods of tuberculosis prevention in children, teenagers and adults. Credit-test on Phthisiopulmonology. Practical class № 5, 6 hours Practical class № 6, 6 hours Practical class № 7, 6 hours NOTE: according to the curriculum 6 hours practical training out of 42 is reserved for independent practice of skills under the guidance of a teacher on the following topics: 1. Making a case report, demonstration of a TB patient at clinical conferences, rounds. 2. Making a referral to TB specialist with details of compulsory diagnostic minimum (CDM) for tuberculosis with setting of presumptive diagnosis according to clinical classification. At the last practical class a credit test on the discipline with situational clinic problems solving and radiographs reading is held. 4 CONTENT OF THE DISCIPLINE Epidemiology of tuberculosis in various countries of the world. General principles of detection, diagnosis and treatment of tuberculosis patients in accordance with WHO recommendations. Prevalence of tuberculosis in countries with different economic levels. Infection, incidence, morbidity and mortality from tuberculosis in different age groups. Strategy of DOTS. Current state and prospects of tuberculosis control. State System of TB control in the Republic of Belarus. Basic methods of radiological diagnosis of pulmonary tuberculosis. The advantage of X-ray and rentgenocomputing research methods in tuberculosis clinic. Segmental structure of lungs in X-ray image in frontal and lateral views. Description of pathological shadow-formation in lungs on basic radiological signs. Continuous and differential (selective) prevention roentgenofluorographic survey. Indications for continuous professional survey of population taking into account epidemiological situation in a region. Diagnostic roentgenofluorographic population survey for tuberculosis for cause, multiplicity of studies, rationale for. The definition of “compulsory contingents”, frequency of their examination. High-risk groups (“threatened contingents”) for tuberculosis. Social groups of risk, health risk factors, epidemiological risk factors, multiplicity of “threatened contingents” survey. Indications and technique of supplementary examination of persons with radiographically identified changes in lungs. Flyuoroteka, shelf-life of rentgendocuments in a clinic. Early detection of tuberculosis by tuberculin diagnosis in children. Objectives of tuberculin diagnosis in mass screening of population and in clinical practice. Types of tuberculin tests. Tuberculin types: CCA, PAP-A; pharmaceutical form, storage conditions. Methodology of a single intracutaneous Mantoux test with 2 TE PPD-L in standard dilution version. Mantoux test results evaluation. The concept of hyperergic, normergic, doubtful and anergic reactions. Indications for use of diagnostic Koch tests with subcutaneous injection of different doses / 20.50 or 100 TE / tuberculin. Evaluation of common, focal and injective reactions at subcutaneous injection of tuberculin. Primary tuberculosis in children. Primary tuberculosis, definition. Primary infection, importance of tuberculin tests in the identification of "conversion". Pathogenesis of primary tuberculosis in children and adolescents. Peculiarities of primary period of tuberculosis infection: the notion of latent microbism and development of hypersensitivity of delayed type (HSDT). Nature of functional abnormalities, clinical manifestations and morphological reactions occurring during primary infection (nonspecific, paraspecific and specific). Main differentia of secondary tuberculosis primary forms. Importance of chemoprophylaxis in primary tuberculosis prevention. Secondary tuberculosis. Focal pulmonary tuberculosis. Definition of focal pulmonary tuberculosis clinical form. Pathomorphological and radiological variants of focal pulmonary tu5 berculosis. Making diagnosis according to clinical classification. Prevalence of focal tuberculosis and its proportion among other clinical forms of secondary tuberculosis. Sources of infection and pathogenesis of soft-focal and fibro-focal tuberculosis of lungs. Clinical symptoms and objective examination of a patient data in soft-focal and fibro-focal pulmonary tuberculosis. "Masks" of focal tuberculosis of lungs. Infiltrative pulmonary tuberculosis. Definition of infiltrative tuberculosis as clinical form of secondary tuberculosis. Prevalence and proportion in morbidity structure among other clinical forms of pulmonary tuberculosis. Pathogenesis and pathomorphology of infiltrative tuberculosis. Radiographic types of infiltrative tuberculosis: broncholobular, rounded, cloud-like, periscituritis, lobitis. Miliary tuberculosis, subacute and chronic disseminated pulmonary tuberculosis. Definition of clinical form. Making diagnosis according to clinical classification. Pathogenesis of hematogenic, lymphogenic and bronchogenic dissemination of tuberculosis mycobacteria: sources of tuberculosis infection, weakening of natural resistance of organism, mycobacteria tuberculosis pathways in a body. Peculiarities of miliary tuberculosis X-ray diagnosis. Clinical picture, diagnosis and treatment of disseminated pulmonary tuberculosis different variants. Caseous pneumonia. Caseous pneumonia as one of acute extensive forms of pulmonary tuberculosis. Pathogenesis of primary and secondary caseous pneumonia. Clinical-radiographic and pathomorphological versions of caseous pneumonia. Clinical picture, diagnosis, differential diagnosis of acute purulent destruction of lungs. Tuberculous pleurisy. Tuberculous pleurisy as clinical form of pulmonary tuberculosis. Pathogenesis of pleurisies of tuberculous etiology, morphological changes of pleura in different types of tuberculous pleurisy. Classification of tuberculous pleurisy. Phases of development exudative pleurisy. Clinical and radiographic diagnosis of various kinds of tuberculous pleurisy. Examination, palpation, percussion and auscultation results in exudative pleurisy. Indications for puncture and evacuation of pleural fluid, methods of their realization. Cytological diagnosis of pleural fluid, difference of serous exudate from transudate. Treatment of patients with exudative tuberculous pleurisy. Outcomes of exudative pleurisy and prognosis. Tuberculosis of the meninges (meningitis). Pathogenesis and pathomorphological variants of tuberculous meningitis. Periods of course and clinical picture of tuberculous meningitis (generalized and neurological symptoms). Nature of cerebrospinal fluid laboratory study in tuberculous meningitis (color, pressure, loss of membrane, levels of protein, sugar, chlorides, cytosis and ratio of blood elements in a smear of liquor sediment, reaction of Pandy and Nonne-Apelt, detection of tuberculosis mycobacteria). Differential diagnosis of tuberculous meningitis, differential signs from serous, virus, purulent meningitis. peculiarities of treatment and outcome of tuberculous meningitis. Cavernous pulmonary tuberculosis. Pathogenesis of cavernous form of tuberculosis. Destruction and cavernous tuberculosis formation reasons. Morphological signs of various forms of tuberculosis and cavernous forms decomposition 6 phases: caverns types depending on morphological structure of the wall. Clinical symptoms of destruction in a lung and cavernous form of tuberculosis. Radiographic signs distinguishing cavernous tuberculosis from other forms of tuberculosis in the phase of disintegration and fibro-cavernous tuberculosis . Differential diagnosis of cavernous tuberculosis from congenital and parasitic cysts, empty lung abscess, decaying of malignant tumors. Fibro-cavernous pulmonary tuberculosis. Making diagnosis according to clinical classification. Formation reasons and pathogenesis of fibro-cavernous tuberculosis. Morphological signs of fibrous caverna. Clinical variants of fibrocavernous pulmonary tuberculosis course. Radiographic signs of fibro-cavernous tuberculosis. Complications of fibrous-cavernous tuberculosis, exacerbation and progression reasons. Methods of patients with fibro-cavernous pulmonary tuberculosis treatment. Outcomes in fibro-cavernous tuberculosis and prognosis. Cirrhotic pulmonary tuberculosis. Definition of cirrhotic pulmonary tuberculosis as a clinical form of pulmonary tuberculosis. The principal difference of cirrhotic pulmonary tuberculosis from cirrhosis of a lung. Reasons of cirrhotic tuberculosis formation, pathogenesis. Morphology of cirrhotic pulmonary tuberculosis. Main clinical symptoms and radiological signs in cirrhotic pulmonary tuberculosis. Differential diagnostics of cirrhotic tuberculosis from cirrhotic non-specific changes in lungs. Pulmonary tuberculosis in combination with other diseases: Tuberculosis in elderly peorsons. Tuberculosis and AIDS. Tuberculosis and maternity. Pulmonary tuberculosis in combination with other diseases (COPD, diabetes, peptic ulcer disease, silicosis, chronic alcoholism). Emergency in pulmonary tuberculosis complications. Pulmonary hemoptysis and pulmonary hemorrhage, pathogenesis. Pathomorphological processes in vessels and tissue surrounding a vessel, channels of blood penetration into bronchi lumen - diapedetic or erosive, initiating agents. Clinical picture of pulmonary hemorrhage and hemoptysis, differences between them. Spontaneous / pathological / pneumothorax, etiology, mechanism of nascency. Pathogenesis of spontaneous pneumothorax in pulmonary tuberculosis, development causes and initiating agents. Types of spontaneous pneumothorax / closed, open, valvular/. Clinical picture of spontaneous pneumothorax depending on a type of pneumothorax, volume of inlet air into pleural cavity, its ingress speed and nature of sensitivity to the complications. Principles and methods of tuberculous patients treatment. Anti-TB preparations, international and national classification according to their effectiveness degree. Vitally important or essential (main), and reserve preparations for tuberculous patients chemotherapy. Basic principles of tuberculosis treatment. Basic principles of chemotherapy (the notion of "regime of chemotherapy"). Improved methods of tuberculous patients chemotherapy in WHO recommendations. Side effects of antituberculosis preparations, classification, clinical manifestations, diagnosis. General principles of prevention and ways of antituberculosis preparations side effects elimination. Methods of pathogenetic treatment of patients with tuber7 culosis. The notion of collapse therapy, main indications and contraindications for curative application of IP and PP. Selection of persons for surgical treatment. Types of surgical interventions in pulmonary tuberculosis, indications and their limitations. Working in a dispensary room. TB dispensaries: types, structure, objectives and organization of work. System of TB service organization in the Republic of Belarus and other countries near and far abroad. Anti-tuberculosis dispensaries. Types of dispensary establishments, structure. Tuberculosis dispensary tasks and organization of its work with other medical institutions of general medical system. Outpatient reception. Grouping TB establishments contingents, treatment and surveillance organization. TB service in polyclinic. Organization of preventive population-based surveys for tuberculosis, their value for annual health examinations of population. Methods of risk-group patients examination for tuberculosis. Indications for sending them to a TB specialist. TB activity of specialized medical and rehabilitation expert committee / MEDNC/. Temporary incapacity for tuberculosis, terms, indications for referral to MEDNC. Methods of tuberculosis prevention. Specific prevention of tuberculosis. Definition of tuberculosis BCG vaccine. Types of tuberculosis BCG vaccine, the release form and storage conditions. The purpose of vaccination and revaccination of children and adults. Indications and contraindications for vaccination of newborns. Peculiarities of vaccination in preterm infants as well as children who was not vaccinated at maternity hospital because of medical contraindications and must be vaccinated in children's polyclinics. Technique of vaccination. Chemoprophylaxis of tuberculosis. The purpose of chemoprophylaxis of tuberculosis. The concept of primary, secondary and anti-relapsing chemoprophylaxis of tuberculosis. Methods of chemoprophylaxis. Contingents of different age groups in need for specific chemoprophylaxis. Sanitary prophylaxis of tuberculosis. Detection of tuberculosis infection nidus. Characteristic of tuberculosis infection nidus on the degree of epidemiological risk. 8 4 42 6 5 - 7 8 TM* Form of achievement control controlled independent work 6 Literature 2 3 2 Phthisiopulmonology (44 hours) 1.1 The 6 course of Medical Faculty 1.1.1 Work in the broncho- 2 logical room and aerosol therapy room. Methods of pathological material getting for BC laboratory detection. Work in a clinical department. Supervision of patients. Evaluation of clinical and laboratory data in supervised patients, substantiation of clinical diagnosis, preparation of clinical observations journals. Work in the clinical and bacteriological laboratories. Mastering the techniques of microscopy and familiarization with the methods of bacteriological investigations for detection of tuberculosis mycobacterium. Classifica- practical (seminar) classes laboratory classes Number of auditorium hours A class material support (visual methodical aids, etc) 1 I. Name of division, theme, class; list of studied questions lectures No of division, class theme TEACHING DISCIPLINE CARD [1] essay [3] [5] [11] 9 tion of tuberculous infection nidus and measures for their improvement. Definition of bacillary criteria in TB patients. Massiveness of bacterioexcretion. 1.1.2 Work in a clinical department. Supervision of patients, performance of scheduled medical manipulations by supervised patients. Paperwork. Work in X-ray room in a dispensary. Radiographic methods of tuberculosis diagnosis. Xray computer test (RCT) of chest organs, computer tomography examination. Technique of radiographic changes in lungs description, making radiological conclusions. Radiographs with various forms of pulmonary tuberculosis reading, improvement of practical skills. Work in fluorography room in a dispensary. Importance and technique of fluorographic examination for the early detection of tuberculosis and other pathological changes of chest. Reading of fluorogram. 1.1.3 Supervision of patients. Achievement control on the topic: "Early detection of tuberculosis by 6 Light stand “Clinical forms of pulmonary TB” [1] [3] [9] [11] Demonstration of a patient on clinic conference 6 Light stand “Clinical forms [1] essay [3] [5] [11] 10 tuberculin diagnostics. Clinical classification of tuberculosis. Peculiarities of pulmonary tuberculosis and extrapulmonary forms of primary tuberculosis (TB of peripheral, mesenteric lymph nodes, tuberculous meningitis) manifistarion. Work in a children room: mastering the technique of tuberculin test setting. Reading and evaluation of Mantoux, Koch tuberculin skin test in patients under treatment. Tuberculin skin test setting for students. 1.1.4 Achievement control on the topic: “Peculiarities of manifestation and course of limited "small" forms and acute forms of tuberculosis.” Supervision of patients, improvement of practical skills. Clinical analysis of patients with focal and infiltrative forms of tuberculosis, tuberculous pleurisy, miliary and subacute disseminated pulmonary tuberculosis, caseous pneumonia. Reading of radiograms, tomograms. Differential diagnosis. Prophylaxis of transition from acute forms of tuberculosis to chronic. of pulmonary TB” 6 TM [1] [3] [9] [11] 11 1.1.5 Achievement control on the topic: " Course and clinical manifestations peculiarities of chronic (chronic disseminated, fibrous-cavernous, cirrhotic) and complicated forms of secondary pulmonary tuberculosis with collapse, seeding, bronchi tuberculosis, colorectal and peritoneum tuberculosis. Differential diagnosis. Supervision of patients. Peculiarities of TB detection in high-risk persons (with COPD, diabetes, peptic ulcer disease, pneumoconiosis, chronic alcoholism, pregnancy, AIDS). Clinical analysis of patients on the class topic. 1.1.6 Achievement control on the topic: "Emergency in tuberculosis complications (hemoptysis, pulmonary hemorrhage, spontaneous pneumothorax), improvement of practical skills. AntiTB preparations, grouping in dependence on efficiency degree. Basic principles of treatment and chemotherapy of pulmonary tuberculosis patients. Supervision of patients. Schemes of tuberculosis patients chemotherapy in accordance with therapeutic categories of WHO recommendations. 6 pneumothorax apparatus, roentgen computer apparatus [1] [3] [9] [11] 6 TM [1] [3] [9] [11] 12 Methods of TB patients intensive treatment (intravenous introduction, intratracheally infusion of preparations and in aerosols, artificial pneumothorax, pneumoperitonium, patients selection for surgical treatment. 1.1.7 Work in a dispensary (outpatient) department. Outpatient reception of patients. Choosing rational methods of tuberculosis patients treatment in outpatient setting. WHO recommendations for outpatient treatment. Methods of tuberculosis prevention in children, adolescents and adults (social, sanitary and specific prevention, vaccination and revaccination, chemoprophylaxis). Importance of health education in anti-tuberculosis efforts. Test on Phthisiopulmonology. Clinical situation tasks. Reading roentgenograms with a conclusion. Assessment of basic practical skills. Interview on program questions of phthisiology. 6 TM [1] Credit test [3] [9] [11] 6-year students of Overseas Students Training Faculty have credit test on the discipline on the last practical class. INFORMATIONAL-METHODICAL PART 13 Basic Literature: Samtsov V.S., Gorbach I.N. “Lecture course on Phthisiology”, Vitebsk, 2001. 2. Samtsov V.S., Volosevich G.V., Gorbach I.N., Romanovsky R.V. “Phthisiopulmonology”, Vitebsk, 2001. 3. Perelman M.I., Koryakin V.A., Bogodelnikova I.V. “Phthisiology”, the 3rd revised and enlarged edition. Moscow, “Meditsina”, 2004, 518 p. 4. Perelman M.I., Koryakin V.A. “Phthisiology” /textbook/. M., 1996. 5. Perelman M.I., Koryakin V.A., Protopopova N.M. “Tuberculosis” /textbook/. M., 1990. 6. Lomako M.N., Sudnik S.I., Sobol S.A. “Guide on Phthisiology”. Minsk, 1991. 7. Samtsov V.S. Study-guide on Phthisiopulmonology for independent preparing to practical classes on Tuberculosis for 4-year medical students of Medical University. Vitebsk, 2006, p.64. 8. Samtsov V.S. Course-book for independent preparing to practical plasses on Tuberculosis for 4-year overseas medical students of Medical University. Vitebsk, 1995. 9. Samtsov V.S., Gorbach I.N., Romanovsky R.V. Study-guide on Phthisiopulmonology for independent preparing to practical classes on Tuberculosis for 6-year medical students of Medical University. Vitebsk, 2006, p.40. 10. Gurevich G.L., Skryagina E.M., Kalechits O.M. Clinical guide on tuberculosis treatment. Minsk, Belsense, 2009, 125p. 1. Additional Literature 1. 2. 3. 4. 5. 6. 7. Tuberculosis of respiratory organs. Guide for physicians. Under editorship of Khomenko A.G., 1988. Tuberculosis. Guide on internal diseases. Under editorship of Khomenko A.G., 1996. Vizel A.A., Guryleva M.A. Tuberculosis (etiology, pathogenesis, clinical forms, diagnostics, treatment). M., 1999. Vasilyev N.A. Tuberculosis (Study guide). M., 1990. Sarcoidosis. Under editorship of Khomenko A.G., Shvaiger O., M., 1982. Bogadelnikova I.V., Perelman M.I. Antibacterial therapy of pulmonary tuberculosis. M., Universum Publishing, 1997. The Order of Ministry of Health of the Republic of Belarus № 143 dated 28.07.1992 “About improvement of antituberculosis service in the Republic of Belarus and measures of its improvement”. 14 The Order of Ministry of Health of the Republic of Belarus № 266 dated 06.12.1996 “About additional measures on strengthening of antituberculsis activity”. 9. The Order of Ministry of Health of the Republic of Belarus № 106 dated 04.07.2002 “About improvement of dispensary observation and tuberculosis patients detection in the Republic of Belarus”. 10. Kroftan D., Horn N., Miller F. Clinical picture of tuberculosis (translation from English). Under editorship of Khomenko A.G., M., 1996. 11. Tuberculosis treatment/Regulations for National programs/.WHO, Geneva. 8. Visual aids: color table on clinical forms of tuberculosis, tables on classification of tuberculosis clinical forms, antituberculosis preparations, mandatory and threatened contingent in investigation for tuberculosis, as well as differential diagnosis and collapse therapy; a light stand “Clinical forms of respiratory organs tuberculosis”; training models on respiratory system; thematic sets of training radiograms with various forms of tuberculosis and other pulmonary pathology; personal computers in the department and university computer labs; training tests on the discipline with the standard of answers; training clinical tasks with the standard of answers; negatoscopes, fluoroscopes, flexible bronchoscopes, pneumothorax apparatus; roentgen computer apparatus (RIC) for chest study; tele-video equipment, devices and diagnostic equipment of functional divisions of regional tuberculous dispensary. PROGRAM QUESTIONS to credit test on Phthisiopulmonology for 6-year students of Overseas Students Training Faculty 1. Epidemiology of tuberculosis in developed and developing countries. 2. System of TB service organization in different countries. 3. Clinical diagnostics of pulmonary tuberculosis. (Characteristics of intoxication syndrome and “thoracic” complaints). 4. Organization and technique of bacteriological diagnostics of tuberculosis. 5. Antiepidemic actions in tuberculosis infection nidus. 6. Methods of tuberculosis detection in children and adolescents. 7. Organization and technique of timeous pulmonary tuberculosis detection in adults. 8. Importance and information value of different methods of X-ray diagnostics in pulmonary tuberculosis. 9. Clinical classification of tuberculosis in the countries of CIS. 10.Tuberculosis risk-groups and prophylactic measures for them. 11.Tuberculosis prevention in children and adults. 12.Tuberculosis dispensary groups in the countries of CIS. Primary registration of patients according to the WHO recommendations. 15 13. Focal pulmonary tuberculosis and its differential diagnostics. 14. Infiltrative pulmonary tuberculosis and its differential diagnostics. 15. Disseminative tuberculosis and its differential diagnostics. 16. Pulmonary tuberculoma and its differential diagnostics. 17. Cavernous tuberculosis and its differential diagnostics. 18. Fibrous-cavernous pulmonary tuberculosis and its differential diagnostics. 19. Tuberculous pleurisy and its differential diagnostics. 20. Primary tuberculous complex and its differential diagnostics. 21. Tuberculosis of intrathoracic lymph nodes and its differential diagnostics. 22. Course peculiarities and prognosis in acute-evolving pulmonary tuberculosis forms. 23. Primary tuberculosis course peculiarities in children and adults. 24.Tuberculous meningitis and its differential diagnostics. 25. Standard chemotherapy scheme of previously untreated tuberculous patients – I and III categories (according to WHO experts’ recommendations). 26. Standard chemotherapy scheme of patients with recrudescence and backsets of tuberculosis and previously treated ineffectively – II category (according to WHO experts’ recommendations). 27.Patients dividing into categories in dependence on character and course of tuberculous process with prescription of polychemotherapy definite condition (according to WHO experts’ recommendations). 28.Standard scheme of chemotherapy of the I medical category patients according to WHO recommendations. 29. Standard scheme of chemotherapy of the II medical category patients according to WHO recommendations. 30. Standard scheme of chemotherapy of the IV medical category patients according to WHO recommendations. 31. Standard scheme of chemotherapy of the III medical category patients according to WHO recommendations. 32. International antituberculous program “DOTS” recommended by WHO. 33. Methods of chemo preparations application control in out-patient conditions. 34. Emergency in pulmonary hemorrhage. 35. Emergency in spontaneous pneumathorax. Oral examination cards on Sate Examination “Internal Diseases” will include the following questions on Phthisiopulmonology. 16 PROGRAM QUESTIONS ON PHTHISIOPULMONOLOGY on State Examination “Internal Diseases” for 6-year students of Overseas Students Training Faculty 1. Organization and technique of timeous pulmonary tuberculosis detection in adults. 2. Organization and technique of bacteriological diagnostics of tuberculosis. 3. Compulsory diagnostic minimum of a patient with suspected tuberculosis examination when directed to dispensary. 4. Primary forms of pulmonary tuberculosis, differential diagnostics. 5. Disseminative and milliard pulmonary tuberculosis, differential diagnostics. 6. Focal pulmonary tuberculosis, its differential diagnostics. 7. Infiltrative pulmonary tuberculosis, differential diagnostics. 8. Acute-evolving pulmonary tuberculosis forms, prognosis, differential diagnostics. 9. Tuberculous meningitis, differential diagnostics. 10. Pulmonary tuberculoma, differential diagnostics. 11. Cavernous tuberculosis, differential diagnostics. 12. Fibrous-cavernous pulmonary tuberculosis, differential diagnostics. 13. Tuberculous pleurisy, differential diagnostics. 14. Sarcoidosis of respiratory system, diagnostics. Lefgren syndrome. 15. Emergency in pulmonary hemorrhage. 16. Early detection of tuberculosis in risk groups, preventive measures. 17. Detection and prophylaxis of tuberculosis in elderly people. 17 PROTOCOL OF APPROVAL OF THE DISCIPLINE EDUCATIONAL PROGRAM “Phthisiology” as a special discipline is not basic among clinic subjects and therefore when mastering knowledge of previous discipline is necessary. However, interaction with concerned clinical departments is performed in accordance with cross-cutting integrate program. There are Protocols of educational programs approval with basic clinical departments. Name of Department of interacdiscipline tion Phthisio- Anatomy Department pulmonology Phthisiopulmonology Neurology with Medical Generics and Neurosurgery Department Suggestions in order of educational material presentation 1. At Anatomy Department studying of the structure, lungs and pleura topography is conducted on system principle from a perspective of their functional anatomy taking into account phthisiopulmonology clinic needs, showing studied organs in anatomical specimens and radiograms. 2. At the Department of Phthisiopulmonology to demonstrate anatomical structures while examining and treating patients, applying modern anatomical terminology for designation of organs. 1. At the Department of Neurology a plan of neurological examination of patients with meningeal syndrome and syndrome of intracranial hypertension, the method of lumbar puncture with studying of cerebrospinal fluid laboratory parameters are practiced. Differential diagnosis of infectious and infectious-allergic diseases of the nervous system. 2. At the Department of Phthisiopulmonology practiced questions pathogenesis of Decision taken Protocol № __ dated __.06.2009 of a decision taken by Anatomy Department Protocol № __ dated __.06.2009 18 Phthisiopulmonology Oncology and Radial Diagnostics Department Phthisiopulmonology General and Clinical Pharmacology Department tuberculous meningitis and central nervous system, clinical pictures, course peculiarities, diagnosis and treatment techniques and outcomes of the disease are practiced. 1. At the Department of Oncology and Radiation Diagnostics methods of radiation diagnosis of respiratory diseases, radiation anatomy of lungs in the norm with lobar and segmental structure, description scheme of pathological shadows on lungs radiograph, acquaintance with radiation pattern of the most common lesions of lungs are practiced. 2. At the Department of Phthisiopulmonology questions of radiation diagnosis of different clinical forms and variants of pulmonary tuberculosis in dynamic observation in progression or reverse the development process to recovery with formation of any residual post-tuberculous changes are studied 1. At the Department of Pharmacology questions of general characteristics and classification of anti-TB drugs, the main pharmacological properties of each, pharmakinetics of drugs, side effects are presented. 2. At the Department of Phthisiopulmonology practiced the basic principles and patterns of combined chemotherapy of different therapeutic categories patients with the definition of treatment courses duration according to WHO Protocol № __ dated __.06.2009 Protocol № __ dated __.06.2009 19 recommendations, as well as questions of prevention and ways to manage side effects when using anti-TB drugs are practiced AMENDMENTS AND ADDITIONS to the educational program on Phthisiopulmonology for 6-year students of Overseas Students Training Faculty of VSMU № Amendments and additions Reason 20 In connection with the Order of the Council of Ministers of the Republic of Belarus "About State program "Tuberculosis" for 2005-2009" a working program on Phthisiopulmonology for 6-year students of Overseas Students Training Faculty must include the main objectives, tasks of the program and main expected results for its implementation. The educational program was reconsidered and approved on the meeting of the Department of Phthisiology (Protocol №__, dated «___» _______.2011) (the name of department) Head of the Department 21 PhD, associate professor (degree, title) ____________ (signature) A.M.Budritsky (print name) APPROVE Dean of the Faculty MD, professor (degree, title) ____________ (signature) V.M.Semyonov (print name) 22