Jizhong Lou
Curriculum Vitae
Jizhong Lou, Ph. D
Personal Information
 Address:
Institute of Biophysics, Chinese Academy of Sciences
15 Datun Rd. Chaoyang District
Beijing 100101, China
Tel: 86-10-64888183
 E-mail: jlou@ibp.ac.cn
 Date and place of birth: May 11, 1975; Suihua, Heilongjiang province, China
 Citizenship: China
 Marital status: Married
 Sex: Male
Educational Background:

Ph. D., Physics, 2000, Institute of Theoretical Physics, Chinese Academy of Sciences,
Beijing, China

M. A., Physics, 1997, Peking University, Beijing, China

B. S., Physics, 1994, Jilin University, Changchun, China
Employment History:

Oct. 2009 – present, Professor, Institute of Biophysics, Chinese Academy of Sciences

Sept. 2005 – Sept. 2009, Research Scientist II, Parker H. Petit Institute for Bioengineering
and Bioscience, Georgia Institute of Technology, Atlanta, Georgia

Oct. 2001 – Aug. 2005, Postdoctoral Fellow, Parker H. Petit Institute for Bioengineering
and Bioscience, Georgia Institute of Technology, Atlanta, Georgia

Oct. 2000 – Sept. 2001, Postdoctoral Fellow, Department of Physics, University of Nevada
Las Vegas, Las Vegas, Nevada
Research Interests:
My research focuses on the studies of the structure-function relationship of proteins and
other biomacromolecules. I utilize computational, experimental and theoretical approaches
to determine 1) how conformations of biomolecules are regulated by external stimuli such as
force and flow, 2) the mechanism of conformation changes at the atomic level, and 3) how
biological functions are affected by these conformational changes.
Publications
A: Peer reviewed articles
1. Liu W, Shang Y, Zeng Y, Liu C, Li Y, Zhai L, Wang P, Lou J, Xu P, Ye Y, Li W. Dimeric
Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin
chains. EMBO J. 2014 Jan 1;33(1):46-61.
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Jizhong Lou
Curriculum Vitae
2. Wang J, Xing X, Fang X, Zhou C, Huang F, Wu Z, Lou J*, and Liang W*, Cationic amphiphilic
drugs self-assemble to the core-shell interface of PEGylated phospholipid micelles and stabilize
micellar structure, Philos Trans A Math Phys Eng Sci. 2013 Sep 2;371(2000):20120309.
3. Sun W, Zhu YJ, Wang Z, Zhong Q, Gao F, Lou J, Gong W, and Xu W. Crystal structure of the
yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations., Nat
Commun. 4:2135 2013.
4. #Lee CY, #Lou J, Wen KK, McKane M, Eskin SG, Ono S, Chien S, Rubenstein PA, Zhu C,
McIntire LV., Actin depolymerization under force is governed by lysine 113:glutamic acid
195-mediated catch-slip bonds, Proc Natl Acad Sci U S A. 110(13):5022-7, 2013. (# These
authors contributed equally)
5. Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L,
Sun F, and Fan Z., Identification of SERPINB1 as a physiological inhibitor of human granzyme
H., J Immunol. 190(3):1319-30, 2013.
6. Zhang Y., and Lou J.*, The Ca2+ Influence on Calmodulin Unfolding Pathway: A Steered
Molecular Dynamics Simulation Study. PLoS ONE 7(11):e49013, 2012. (*corresponding
author)
7. Chen W, Lou J., Evans E. A., and Zhu C., Observing force-regulated conformational changes
and ligand dissociation from a single integrin on living cells. J Cell Biol., 199(3):497-512, 2012.
8. Zhang D, Liu G, Xue J, Lou J, Nierhaus KH, Gong W, and Qin Y., Common chaperone activity
in the G-domain of trGTPase protects L11-L12 interaction on the ribosome. Nucleic Acids Res.
40(21):10851-65, 2012.
9. #Yu C., #Lou J., Wu J., Pan L., Feng W., and Zhang M., Membrane-induced Lever Arm
Expansion Allows Myosin VI to Walk with Large and Variable Step Sizes. J Biol Chem 287 (42):
35021-35, 2012. (# These authors contributed equally)
10. Bai M., Pang X, Lou J., Zhou Q., Zhang K., Ma J., Li J., Sun F., and Hsu V. W., Molecular
elucidation of regulated cargo binding by ACAP1. J Biol Chem, 287(34):28675-85, 2012.
11. Xiang X., Lee C.-Y., Li T., Chen W., Lou J.*, and Zhu, C.*, Structural basis and kinetics of
force-induced conformational changes of an <alpha>A domain-containing integrin. PLoS ONE
6(11): e27946, 2011. (* corresponding author)
12. Zhou Q., Zhai Y., Lou, J., Liu M., Pang X., and Sun F., Thiabendazole inhibits uniquinone
reduction activity of mitochondrial respiratory complex II via a water molecule mediated
binding feature, Protein Cell 2(7):531-542, 2011.
13. Huang Q.S., Lou J.*, Wu J. H., and Zhu C., Conformational transitions of glycoprotein Ibalpha
mutants in flow molecular dynamics simulation, Cell. Mol. Bioeng. 4(3):495-504, 2011. (*
corresponding author)
14. Chen W., Lou J., Hsin J., Schulten K., Harvey S. C., and Zhu C., Molecular dynamics
simulations of forced unbending of integrin αVβ3. PLoS Comput. Biol. 7(2):e1001086, 2011.
15. Chen W., Lou J., and Zhu C., Forcing switch from short- to intermediate- and long-lived states
of the αA domain generates LFA-1/ICAM-1 catch bond, J. Biol Chem. 285(46):35967-78
(2010).
16. Chen W., Lou J., and Zhu C., Simulated Thermal Unfolding of the von Willebrand Factor A
Domains, Cellular and Molecular Bioengineering, 3(2):117-127 (2010).
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Jizhong Lou
Curriculum Vitae
17. Chen W., Lou J., and Zhu C., Molecular Dynamics Simulated Unfolding of von Willebrand
Factor A Domains by Force, Cellular and Molecular Bioengineering, 2(1):75-86 (2009).
18. #Yago T., #Lou J., #Wu T., Yang J., Miner J. J., Coburn L., Lopez J. A., Cruz M. A., Dong J.-F.,
McIntire L. V., McEver R. P., and Zhu C., Platelet glycoprotein Ibα forms catch bonds with WT
VWF but not with type 2B von Willebrand Disease VWF, J. Clin. Invest., 118:3195-3207
(2008). (# These authors contributed equally)
19. Lou J., and Zhu C., Flow induces loop to β-hairpin transition on the β-switch of platelet
glycoprotein Ibα, Proc. Natl. Acad. Sci. USA, 105:13847-13852 (2008).
20. Chen Z., Lou J., Zhu C., and Schulten K., Flow Induced Structural Transition in the β-switch
Region of Glycoprotein Ib, Biophys J., 95:1303-1313 (2008).
21. Zhu C., Yago T., Lou J., Zarnitsyna V. I., and McEver R. P., Mechanisms for flow-enhanced cell
adhesion, Ann. Biomed. Eng., 36(4):604-621 (2008).
22. Lou J., Yago T., McEver R.P., and Zhu C., The sliding-rebinding mechanism for catch bonds,
Jap. J. Appl. Phys. 46 (8B): 5528-5535 (2007).
23. Lou J., and Zhu C., A structure-based sliding-rebinding mechanism for catch bonds, Biophys J.,
92:1471-85 (2007).
24. #Lou J.,#Yago T., #Klopocki A. G., Metha P., Chen W., Zarnitsyna V. I., Bovin N. V., Zhu C.,
and McEver R. P., Flow-enhanced adhesion regulated by a selectin interdomain hinge, J. Cell
Biol., 174:1107-1117 (2006). ( # These authors contributed equally)
25. Zhu C., Lou J., McEver R. P., Catch Bonds: Physical Models, Structural Bases, Biological
Functions, and Rheological Relevance, Biorheology 42, 443-462 (2005).
26. Marshall B. T., Sarangapani K. K., Lou J., McEver R. P., and Zhu C., Force history dependence
of receptor-ligand dissociation, Biophys J. 88, 1458 (2005).
27. Lou J., Chen C., and Wang X., Field-induced midgap edge excitations in quantum spin chains,
Phys. Rev. B 73, 092407 (2006).
28. Zhao J., Wang X., Xiang T., Su Z.-B., Yu L., Lou J., and Chen C., Antiferromagnetic
Heisenberg ladders in staggered magnetic field, Phys. Rev. B 73, 012411 (2006).
29. Ye F., Wang, B.-S., Lou J., and Su Z.-B., Correlation effects for semiconducting single-wall
carbon nanotubes: A density matrix renormalization group study, Phys. Rev. B 72, 233409
(2005).
30. Lou J., Chen C., Zhao J., Wang X., Xiang T., Su Z.-B., and Yu L., Midgap states in
antiferromagnetic Heisenberg chains with a staggered field, Physical Review Letters 2005, 94
(21): Art. No. 217207.
31. Gu B., Lou J., Qin S., and Xiang T., Exciton excitations in a one-dimensional band insulator
with Hubbard interactions, CHINESE PHYSICS LETTERS 21 (3): 530-533 MAR 2004.
32. Lou J., Qin S., and Chen C., String Order in Half-Integer-Spin Antiferromagnetic Heisenberg
Chains, Phys. Rev. Lett. 91, 087204 (2003).
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Jizhong Lou
Curriculum Vitae
33. Lou J., Qin S., Xiang T., Chen C., Tian G.-S. and Su Z.-B., Transition from band insulator to
Mott insulator in one dimension: Critical behavior and phase diagram, Phys. Rev. B 68, 045110
(2003).
34. Qin S., Lou J., Sun L., and Chen C., Nonlocal Topological Order in Antiferromagnetic
Heisenberg Chains, Phys. Rev. Lett. 90, 067202 (2003).
35. Lou J., Qin S., Ng T.-K., and Su Z.-B., Topological effects in short antiferromagnetic
Heisenberg chains, Phys. Rev. B 65, 104401 (2002).
36. Lou J., Qin S., Chen C., Su Z.-B., and Yu L., Field-induced gap in the spin-1/2
antiferromagnetic Heisenberg chain: A density-matrix renormalization-group study, Phys. Rev.
B 65, 064420 (2002).
37. Lou J., Chen C., and Qin S., Low-energy properties and magnetization plateaus in a two-leg
mixed spin ladder, Phys. Rev. B 64, 144403 (2001).
38. Liu Y., Chen Y., Lou J., Qin S., and Chen H., Magnetization of a gapped spin 1/2
antiferromagnetic ising chain near the critical external field, COMMUN THEOR PHYS 36, 733
(2001).
39. Xiang T., Lou J., and Su Z.-B., Two-dimensional algorithm of the density-matrix
renormalization group, Phys. Rev. B 64, 104414 (2001).
40. Qin S., and Lou J., Memory, time and technique aspects of density matrix renormalization
group method, COMMUN THEOR PHYS 36, 635 (2001).
41. Lou J., Xaing T. and Su Z.-B., Thermodynamics of the Bilinear-Biquadratic Spin-One
Heisenberg Chain, Phys. Rev. Lett. 85, 2380-2383 (2000).
42. Lou J., Qin S., and Su Z.-B., Magnetization of the S=2 antiferromagnetic Heisenberg chain near
the critical magnetic field, Phys. Rev. B 62, 13832-13835 (2000).
43. Lou J., Dai J., Qin S., Su Z.-B., and Yu L., Logarithmic corrections to the ground state energy
of finite spin-1/2 antiferromagnetic chains due to ferromagnetic end bonds, Phys. Rev. B 62,
8600-8603 (200).
44. Lou J., Qin S., Ng T.-K., Su Z.-B., and Affleck I., Finite-size spectrum, magnon interactions,
and magnetization of S=1 Heisenberg spin chains, Phys. Rev. B 62, 3786-3794 (2000).
45. Ng T.-K., Lou J., and Su Z.-B., Effects of substituting the rare-earth ion R by nonmagnetic
impurities in R2BaNiO5: Theory and numerical density-matrix renormalization-group results,
Phys. Rev. B 61, 11487-11491 (2000).
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Jizhong Lou
Curriculum Vitae
46. Lou J., Dai X., Qin S., Su Z.-B., and Yu L., Heisenberg spin-1 chain in a staggered magnetic
field:A DMRG study, Phys. Rev. B 60, 52-55 (1999).
47. Lou J., Qin S., Su Z.-B., and Yu L., Bond-versus-site doping models for the off-chain-doped
Haldane-gap system Y2BaNiO5, Phys. Rev. B 58, 12672-12675 (1998).
48. Lou J., Qin D.-H., Ding Y.-B., and Chao K.-T., C(b)over-bar system: Mass spectra and decays,
COMMUN THEOR PHYS 30, 93 (1998).
49. Wu L.-A., Lou J., and Jing X.-G., Quantum rotational band formulas from a 2-parameter
potential and the microscopic explanation from the fermion dynamical symmetry model, PHYS
REV C 51, 2998 (1995).
B: Conference proceedings/Book chapters
50. Lou J., Zhu C., Yago T. and McEver R. P., A Sliding-Rebinding Mechanism for Catch Bonds,
in Biomechanics at Micro- and Nanoscale Levels, Vol III, edited by Hiroshi Wada, World
Scientific Publishing Co. 2007.
51. Qin S., Lou J., Su Z.-B., and Yu L., Strongly Correlated Complex Systems in Density Matrix
Renormalizaiton: A New Numerical Method in Physics, Lecture Notes in Physics, vol. 528,
edited by I. Peschel, X. Wang, M. Kaulke and K. Hallberg. Springer-Verlag, Berlin, 1999,
p.271.
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