Seznam vědeckých a odborných prací, učebnic a učebních textů:
a. Kapitoly v monografiích
1. HOZÁK P., ZATSEPINA O.V. and LIKOVSKÝ Z. Nucleolar changes in hypotonic
treatment and the possibility of isolation of nucleolar fibrillar complexes. Nuclear Structure
and Function, Harris J.R., and Zbarsky I.B., New York: Eds., Plenum Press, 1990. 197202 s
2. COOK P.R., DOLLE A., HASSAN A.B., HOZAK P. and JACKSON D.A. The role of the
nucleoskeleton in RNA metabolism. In: Nucleic Acids and Molecular Biology, Vol. 7, ed.
by F. Eckstein and D.M.J. Lilley, Springer-Verlag, Berlin - Heidelberg, 1993. 226-237 s
3. WACHTLER F., MOSGOELLER W., SCHOEFER C., SYLVESTER J., HOZAK P.,
DERENZINI M. and STAHL A. Ribosomal genes and nucleolar morphology. In:
Chromosomes Today, Vol. 11, Sumner A.T. and Chandley A.C. Eds., Chapman & Hall,
London, 1993. 63-77 s
4. HOZAK P., JACKSON D.A. and COOK P.R. Role of nuclear structure in DNA replication.
In: Eukaryotic DNA Replication - Frontiers in Molecular Biology. J.J. Blow, Ed., Oxford:
Oxford University Press, Chapter 5, 1996. 124-142 s
b. Původní vědecké práce
1. HOZAK, P., ZATSEPINA, O., VASILYEVA, I. and CHENTSOV, Y. An electron
microscopic study of nucleolus-organizing regions at some stages of the cell cycle (G0
period, G2 period, mitosis). Biol Cell, 1986, 57, 197-205.
IF 1.829
2. ZATSEPINA, O., HOZAK, P., BABADJANYAN, D. and CHENTSOV, Y. Quantitative
ultrastructural study of nucleolus-organizing regions at some stages of the cell cycle (G0
period, G2 period, mitosis). Biol Cell, 1988, 62, 211-218.
IF 1.829
3. HOZAK, P., NOVAK, J. T. and SMETANA, K. Three-dimensional reconstructions of
nucleolus-organizing regions in PHA-stimulated human lymphocytes. Biol Cell, 1989, 66,
225-233.
IF 1.829
4. HOZAK, P., ZATSEPINA, O. V. and LIKOVSKY, Z. In situ separation of nucleolar
components by hypotonic treatment of cells. Biol Cell, 1990, 68, 167-170.
IF 1.829
5. BEHALOVA, B., HOZAK, P., BLAHOVA, M. and SILLINGER, V. Effect of nitrogen
limitation and sporulation on sterol and lipid formation in Saccharomyces cerevisiae. Folia
Microbiol (Praha), 1992, 37, 442-449.
IF 0.776
6. HOZAK, P., GERAUD, G. and HERNANDEZ-VERDUN, D. Revealing nucleolar
architecture by low ionic strength treatment. Exp Cell Res, 1992, 203, 128-133.
IF 5.096
-1-
7. HOZAK, P., ROUSSEL, P. and HERNANDEZ-VERDUN, D. Procedures for specific
detection of silver-stained nucleolar proteins on western blots. J Histochem Cytochem,
1992, 40, 1089-1096.
IF 2.718
8. HOZAK, P., HASSAN, A. B., JACKSON, D. A. and COOK, P. R. Visualization of
replication factories attached to nucleoskeleton. Cell, 1993, 73, 361-373.
IF 29.219
9. HOZAK, P., SCHOFER, C., SYLVESTER, J. and WACHTLER, F. A study on nucleolar
DNA: isolation of DNA from fibrillar components and ultrastructural localization of different
DNA probes. J Cell Sci, 1993, 104 ( Pt 4), 1199-1205.
IF 6.213
10. HOZAK, P., JACKSON, D. A. and COOK, P. R. Replication factories and nuclear bodies:
the ultrastructural characterization of replication sites during the cell cycle. J Cell Sci,
1994, 107 ( Pt 8), 2191-2202.
IF 6.213
11. HOZAK, P. and COOK, P. R. Replication factories. Trends Cell Biol, 1994, 4, 48-52.
IF 18.135
12. HOZAK, P., COOK, P. R., SCHOFER, C., MOSGOLLER, W. and WACHTLER, F. Site of
transcription of ribosomal RNA and intranucleolar structure in HeLa cells. J Cell Sci, 1994,
107 ( Pt 2), 639-648.
IF 6.213
13. HOZAK, P. Catching RNA polymerase I in Flagranti: ribosomal genes are transcribed in
the dense fibrillar component of the nucleolus. Exp Cell Res, 1995, 216, 285-289.
IF 5.096
14. HOZAK, P., SASSEVILLE, A. M., RAYMOND, Y. and COOK, P. R. Lamin proteins form
an internal nucleoskeleton as well as a peripheral lamina in human cells. J Cell Sci, 1995,
108, 635-644.
IF 6.213
15. HUGHES, T. A., POMBO, A., MCMANUS, J., HOZAK, P., JACKSON, D. A. and COOK,
P. R. On the structure of replication and transcription factories. J Cell Sci Suppl, 1995, 19,
59-65.
IF 6.213
16. HOZAK, P. The nucleoskeleton and attached activities. Exp Cell Res, 1996, 229, 267271.
IF 5.096
17. KANKA, J., HOZAK, P., HEYMAN, Y., CHESNE, P., DEGROLARD, J., RENARD, J. P.
and FLECHON, J. E. Transcriptional activity and nucleolar ultrastructure of embryonic
rabbit nuclei after transplantation to enucleated oocytes. Mol Reprod Dev, 1996, 43, 135144.
IF 2.296
18. MOSGOELLER, W., STEINER, M., HOZAK, P., PENNER, E. and WESIERSKA-GADEK,
J. Nuclear architecture and ultrastructural distribution of poly(ADP-ribosyl)transferase, a
multifunctional enzyme. J Cell Sci, 1996, 109 ( Pt 2), 409-418.
IF 6.910
-2-
19. WEIPOLTSHAMMER, K., SCHOFER, C., WACHTLER, F. and HOZAK, P. The
transcription unit of ribosomal genes is attached to the nuclear skeleton. Exp Cell Res,
1996, 227, 374-379.
IF 4.007
20. GEUSSOVA, G., PEKNICOVA, J., CAPKOVA, J., KALAB, P., MOOS, J.,
PHILIMONENKO, V. V. and HOZAK, P. Monoclonal antibodies to canine intra-acrosomal
sperm proteins recognizing acrosomal status during capacitation and acrosome reaction.
Andrologia, 1997, 29, 261-268.
IF 0.732
21. NOWAK, G., PESTIC-DRAGOVICH, L., HOZAK, P., PHILIMONENKO, A., SIMERLY, C.,
SCHATTEN, G. and DE LANEROLLE, P. Evidence for the presence of myosin I in the
nucleus. J Biol Chem, 1997, 272, 17176-17181.
IF 7.258
22. MOOS, J., PEKNICOVA, J., GEUSSOVA, G., PHILIMONENKO, V. and HOZAK, P.
Association of protein kinase A type I with detergent-resistant structures of mammalian
sperm cells. Mol Reprod Dev, 1998, 50, 79-85.
IF 2.296
23. SMETANA, K., JIRASKOVA, I., SEDLACKOVA, M., DVORAK, R., SPATOVA, M. and
HOZAK, P. Preferential silver reaction of nucleolar regions adjacent to fibrillar centers in
ring shaped nucleoli of leukemic lymphocytes. Acta Histochem, 1998, 100, 257-270.
IF 0.865
24. WEIPOLTSHAMMER, K., SCHOFER, C., ALMEDER, M., PHILIMONENKO, V. V., FREI,
K., WACHTLER, F. and HOZAK, P. Intranuclear anchoring of repetitive DNA sequences:
centromeres, telomeres, and ribosomal DNA. J Cell Biol, 1999, 147, 1409-1418.
IF 12.880
25. PESTIC-DRAGOVICH, L., STOJILJKOVIC, L., PHILIMONENKO, A. A., NOWAK, G., KE,
Y., SETTLAGE, R. E., SHABANOWITZ, J., HUNT, D. F., HOZAK, P. and DE
LANEROLLE, P. A myosin I isoform in the nucleus. Science, 2000, 290, 337-341.
IF 23.329
26. PHILIMONENKO, A. A., JANACEK, J. and HOZAK, P. Statistical evaluation of
colocalization patterns in immunogold labeling experiments. J Struct Biol, 2000, 132, 201210.
IF 3.671
27. MOSGOELLER, W., SCHOFER, C., STEINER, M., SYLVESTER, J. E. and HOZAK, P.
Arrangement of ribosomal genes in nucleolar domains revealed by detection of
"Christmas tree" components. Histochem Cell Biol, 2001, 116, 495-505.
IF 2.477
28. PEKNICOVA, J., KUBATOVA, A., SULIMENKO, V., DRABEROVA, E., VIKLICKY, V.,
HOZAK, P. and DRABER, P. Differential subcellular distribution of tubulin epitopes in
boar spermatozoa: recognition of class III beta-tubulin epitope in sperm tail. Biol Reprod,
2001, 65, 672-679.
IF 3.508
29. PHILIMONENKO, V. V., FLECHON, J. E. and HOZAK, P. The nucleoskeleton: a
permanent structure of cell nuclei regardless of their transcriptional activity. Exp Cell Res,
2001, 264, 201-210.
-3-
IF 5.096
30. RICHTEROVA, Z., LIEBL, D., HORAK, M., PALKOVA, Z., STOKROVA, J., HOZAK, P.,
KORB, J. and FORSTOVA, J. Caveolae are involved in the trafficking of mouse
polyomavirus virions and artificial VP1 pseudocapsids toward cell nuclei. J Virol, 2001, 75,
10880-10891.
IF 5.398
31. SUTOVSKY, P., MOTLIK, J., NEUBER, E., PAVLOK, A., SCHATTEN, G., PALECEK, J.,
HYTTEL, P., ADEBAYO, O. T., ADWAN, K., ALBERIO, R., BAGIS, H., BATAINEH, Z.,
BJERREGAARD, B., BODO, S., BRYJA, V., CARRINGTON, M., COUF, M., DE LA
FUENTE, R., DIBLIK, J., ESNER, M., FOREJT, J., FULKA, J., JR., GEUSSOVA, G.,
GJORRET, J. O., LIBIK, M., HAMPL, A., HASSANE, M. S., HOUSHMAND, M., HOZAK,
P., JEZOVA, M., KANIA, G., KANKA, J., KANDIL, O. M., KISHIMOTO, T., KLIMA, J.,
KOHOUTEK, J., KOPSKA, T., KUBELKA, M., LAPATHITIS, G., LAURINCIK, J.,
LEFEVRE, B., MIHALIK, J., NOVAKOVA, M., OKO, R., OMELKA, R., OWINY, D.,
PACHERNIK, J., PACHOLIKOVA, J., PEKNICOVA, J., PESTY, A., PONYA, Z.,
PRECLIKOVA, H., SLOSKOVA, A., SVOBODA, P., STREJCEK, F., TOTH, S., TEPLA,
O., VALDIVIA, M., VODICKA, P. and ZUDOVA, D. Accumulation of the proteolytic marker
peptide ubiquitin in the trophoblast of mammalian blastocysts. Cloning Stem Cells, 2001,
3, 157-161.
IF neuveden
32. FUCHSOVA, B. and HOZAK, P. The localization of nuclear DNA helicase II in different
nuclear compartments is linked to transcription. Exp Cell Res, 2002, 279, 260-270.
IF 5.096
33. FUCHSOVA, B., NOVAK, P., KAFKOVA, J. and HOZAK, P. Nuclear DNA helicase II is
recruited to IFN-alpha-activated transcription sites at PML nuclear bodies. J Cell Biol,
2002, 158, 463-473.
IF 12.915
34. IBEN, S., TSCHOCHNER, H., BIER, M., HOOGSTRATEN, D., HOZAK, P., EGLY, J. M.
and GRUMMT, I. TFIIH plays an essential role in RNA polymerase I transcription. Cell,
2002, 109, 297-306.
IF 29.219
35. PHILIMONENKO, V. V., JANACEK, J. and HOZAK, P. LR White is preferable to Unicryl
for immunogold detection of fixation-sensitive nuclear antigens. Eur J Histochem, 2002,
46, 359-364.
IF 0.959
36. JIRASEK, T., HOZAK, P. and MANDYS, V. Different patterns of chromogranin A and
Leu-7 (CD57) expression in gastrointestinal carcinoids: immunohistochemical and
confocal laser scanning microscopy study. Neoplasma, 2003, 50, 1-7.
IF 0.637
37. BARAN, V., PAVLOK, A., BJERREGAARD, B., WRENZYCKI, C., HERMANN, D.,
PHILIMONENKO, V. V., LAPATHITIS, G., HOZAK, P., NIEMANN, H. and MOTLIK, J.
Immunolocalization of upstream binding factor and pocket protein p130 during final
stages of bovine oocyte growth. Biol Reprod, 2004, 70, 877-886.
IF 3.550
38. BJERREGAARD, B., WRENZYCKI, C., PHILIMONENKO, V. V., HOZAK, P., LAURINCIK,
J., NIEMANN, H., MOTLIK, J. and MADDOX-HYTTEL, P. Regulation of ribosomal RNA
-4-
synthesis during the final phases of porcine oocyte growth. Biol Reprod, 2004, 70, 925935.
IF 3.550
39. CHOVANEC, M., SMETANA, K., JR., PURKRABKOVA, T., HOLIKOVA, Z.,
DVORANKOVA, B., ANDRE, S., PYTLIK, R., HOZAK, P., PLZAK, J., SEDO, A., VACIK,
J. and GABIUS, H. Detection of cell type and marker specificity of nuclear binding sites
for anionic carbohydrate ligands. Biotech Histochem, 2004, 79, 139-150.
IF 0.484
40. DEGROUARD, J., HOZAK, P., HEYMAN, Y. and FLECHON, J. E. Nucleoskeleton of
early bovine embryos and differentiated somatic cells: an ultrastructural and
immunocytochemical comparison. Histochem Cell Biol, 2004, 121, 441-451.
IF 2.594
41. HOFMANN, W. A., STOJILJKOVIC, L., FUCHSOVA, B., VARGAS, G. M.,
MAVROMMATIS, E., PHILIMONENKO, V., KYSELA, K., GOODRICH, J. A., LESSARD,
J. L., HOPE, T. J., HOZAK, P. and DE LANEROLLE, P. Actin is part of pre-initiation
complexes and is necessary for transcription by RNA polymerase II. Nat Cell Biol, 2004,
6, 1094-1101.
IF 20.649
42. LIBUSOVA, L., SULIMENKO, T., SULIMENKO, V., HOZAK, P. and DRABER, P. gammaTubulin in Leishmania: cell cycle-dependent changes in subcellular localization and
heterogeneity of its isoforms. Exp Cell Res, 2004, 295, 375-386.
IF 4.007
43. MULLEROVA, J. and HOZAK, P. Use of recombinant congenic strains in mapping
disease-modifying genes. News Physiol Sci, 2004, 19, 105-109.
IF 3.306
44. PHILIMONENKO, V. V., ZHAO, J., IBEN, S., DINGOVA, H., KYSELA, K., KAHLE, M.,
ZENTGRAF, H., HOFMANN, W. A., DE LANEROLLE, P., HOZAK, P. and GRUMMT, I.
Nuclear actin and myosin I are required for RNA polymerase I transcription. Nat Cell Biol,
2004, 6, 1165-1172.
IF 20.649
45. PHILIMONENKO, A. A., JACKSON, D. A., HODNY, Z., JANACEK, J., COOK, P. R. and
HOZAK, P. Dynamics of DNA replication: an ultrastructural study. J Struct Biol, 2004, 148,
279-289.
IF 3.132
46. SCHOFER, C., JANACEK, J., WEIPOLTSHAMMER, K., POURANI, J. and HOZAK, P.
Mapping of cellular compartments based on ultrastructural immunogold labeling. J Struct
Biol, 2004, 147, 128-135.
IF 3.132
47. BARAN, V., KOVAROVA, H., KLIMA, J., HOZAK, P. and MOTLIK, J. Re-localization of
nuclear DNA helicase II during the growth period of bovine oocytes. Histochem Cell Biol,
2005, 1-10.
IF 2.594
48. CEBECAUER, M., GUILLAUME, P., HOZAK, P., MARK, S., EVERETT, H., SCHNEIDER,
P. and LUESCHER, I. F. Soluble MHC-peptide complexes induce rapid death of CD8+
CTL. J Immunol, 2005, 174, 6809-6819.
-5-
IF 6.486
49. FELTL, D., ZAVADOVA, E., PALA, M. and HOZAK, P. The dynamics of plasma
transforming growth factor beta 1 (TGF-beta1) level during radiotherapy with or without
simultaneous chemotherapy in advanced head and neck cancer. Oral Oncol, 2005, 41,
208-213.
IF 2.000
50. FELTL, D., ZAVADOVA, E., PALA, M. and HOZAK, P. Post-treatment plasma
transforming growth factor beta 1 (TGF-beta1) level predicts for late morbidity in patients
with advanced head and neck cancer. Neoplasma, 2005, 52, 393-397.
IF 0.822
51. HOZAK, P. and FAKAN, S. Functional structure of the cell nucleus. Histochem Cell Biol,
2005, 1-2.
IF 2.594
52. KYSELA, K., PHILIMONENKO, A. A., PHILIMONENKO, V. V., JANACEK, J., KAHLE, M.
and HOZAK, P. Nuclear distribution of actin and myosin I depends on transcriptional
activity of the cell. Histochem Cell Biol, 2005, 124, 347-358.
IF 2.594
53. LIBUSOVA, L., SULIMENKO, T., SULIMENKO, V., JANISCH, R., HOZAK, P. and
DRABER, P. Distinct localization of a beta-tubulin epitope in the Tetrahymena
thermophila and Paramecium caudatum cortex. Protoplasma, 2005, 225, 157-167.
IF 1.625
54. PEKNICOVA, J., CHLADEK, D. and HOZAK, P. Monoclonal antibodies against sperm
intra-acrosomal antigens as markers for male infertility diagnostics and estimation of
spermatogenesis. Am J Reprod Immunol, 2005, 53, 42-49.
IF 1.808
55. PHILIMONENKO, A. A., HODNY, Z., JACKSON, D. A. and HOZAK, P. The
microarchitecture of DNA replication domains. Histochem Cell Biol, 2005, 1-15.
IF 2.594
56. POKORNA, D., CEROVSKA, N., SMAHEL, M., MORAVEC, T., LUDVIKOVA, V.,
MACKOVA, J., SYNKOVA, H., DUSKOVA, M., HOZAK, P. and VELEMINSKY, J. DNA
vaccines based on chimeric potyvirus-like particles carrying HPV16 E7 peptide (aa 4460). Oncol Rep, 2005, 14, 1045-1053.
IF 1.356
57. BARAN V., KOVAROVA H., KLIMA J., HOZAK P., MOTLIK J. Re-localization of nuclear
DNA helicase II during the growth period of bovine oocytes. Histochem Cell Biol, 2006,
125, 155-164
IF bude publikován v roce 2007
58. HOZAK P., FAKAN S. Functional structure of the cell nucleus. Histochem Cell Biol, 2006,
125, 1-2
IF bude publikován v roce 2007
59. NOVAKOVA Z., MAN P., NOVAK P., HOZAK P., HODNY Z. Separation of nuclear
protein complexes by blue native polyacrylamide gel electrophoresis. Electrophoresis,
2006, 27, 1 - 11
IF bude publikován v roce 2007
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c. Učebnice a učební texty
1. Kolektiv autorů; editor J. Jonák, Molekulární biologie a genetika VIII. (kapitola o
buněčném jádře). Praha: Nakl. Akademie věd České republiky, Ústav molekulární
genetiky, 1998. ISBN: 80-902588-0-8
2. Spolupřekladatel učebnice: Alberts a kol, „Základy buněčné biologie“. Praha: Espero
Publishing, 2001. ISBN: 80-902906-0-4
d. Vybrané přednášky typu „invited speaker“
Dept. of Zoology, University of Oxford, U.K
Inst. of Histology and Embryology, University of Vienna, Austria
J. Monod Institute, CNRS, Paris, France
Paterson Symposium, Paterson Inst. for Cancer Research, Manchester, U.K.
Gordon Research Conference "Biological Structure&Gene Expression", Newport,RI,USA
Eurem, Dublin, Irsko
Nobel Symposium, Stockholm, Sweden
Eurem, Cancun, Mexiko
Research Institute of Tumor Biology, Heidelberg, Germany
4th Multinational Congress on Electron Microscopy, Veszprém, Hungary
University of Madrid, Spain
University of Istanbul, Turkey
Windows to a Zygote, UNESCO Course, Praha
5th Multinational Congress on Electron Microscopy, Lecce, Italy
The Dynamic Nucleus, Imperial College, London, UK
15th International Congress on Electron Microscopy, Durban, South Africa
7th Multinational Congress on Microscopy, Portoroz, Slovenia
University of Pavia
Biocenter Vienna
2nd Croatian Congress on Microscopy, Topusko, Chorvatsko
10th International Microscopy Congress, Sapporo, Japonsko
e. Disertační a habilitační práce
1. Disertační práce k získání CSc. - 1997: Závislost ultrastruktury a prostorového
uspořádání nukleolárních organizátorů na transkripční aktivitě, ČSAV/UK v Praze
2. Disertační práce k získání DrSc. 2001 – Funkční mikroarchitektura buněčného jádra,
AV ČR
3. Habilitační práce – 2002: Funkční mikroarchitektura buněčného jádra, UK v Praze
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l.
Účast na řešení grantů
Řešitel úspěšně zakončených projektů:
3. Nukleoskelet a replikační tělíska. GA AV ČR, A539402, (1994-1996)
4. Molecular structure of replication factories. The Wellcome Trust, (1995-1998)
5. Funkční mikroarchitektura nukleoskeletu. GA AV ČR, A5039701, (1997-2001)
6. Intranukleární pohyb a genová exprese. GA ČR, 304/98/1035, (1998-2000)
7. Identification of nuclear structures involved in gene expression. Spolupráce s prof.
Wachtlerem, Vídeňská universita, AKTION, (1998-2000)
8. Characterization of a putative nuclear myosin I. Spolupráce s Prof. deLanerolle,
University of Illinois at Chicago. NSF USA, (1998-2000)
9. Epigenetic gene-position effects in gene expression of tumor cells. Spolupráce s Prof.
Mosgoellerem, Vídeňská universita. AKTION, (2001-2002).
10. Characterization of nuclear myosin I. Spolupráce s Prof. deLanerolle, University of
Illinois at Chicago. NSF USA, (2001-2003)
11. Zřízení praktik buněčné a molekulární biologie na 3. LF UK, FRVŠ, 2002
12. Molekulární anatomie struktur řídících jadernou kompartmentalizaci. GA AV ČR,
IAA5039202, (2001-2005)
13. Charakterizace jaderného myosinu I. GA ČR, 304/01/0661, (2001-2003)
Řešitel/koordináter běžících projektů:
14. Funkce jaderného myosinu v genové expresi. GA ČR 2004/04/0108, (2004-2006)
15. Control of stress and interferon-regulated gene expression by transcription factors,
histone modification and nuclear compartmentalization. European Science
Foundation/Grant Agency of the Czech Republic, DYN/04/E002 (2005-2007)
16. Molekulární biologie diferencující se buňky. PhD programový grant GA ČR,
204/05/H023, (2005-2008)
17. Centrum funkční organizace buňky. MŠMT, LC 545, (2005-2009)
18. Fluorescenční mikroskopie v biologickém a lékařském výzkumu. MŠMT, LC0603,
(2006-2010)
Doc. RNDr. Pavel Hozák, DrSc.
V Praze dne 8.6.2006
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