David C. Lathbury, Ph.D., FRSC
PROFESSIONAL EXPERIENCE
AMRI
Albany, New York 12203
2010-April 2014

Vice President
Chemical Development
The Vice President, Chemical Development is the leader of all project groups and
is responsible for: (i) leading productive experimental programs, (ii) effectively
communicating results and issues within the projects and management and client
organizations, (iii) identifying and developing new business opportunities, (iv)
initiating and leading proprietary research activities within the organization, as
appropriate and (v) the operations of the GMP laboratories.
AstraZeneca Process R&D (PR&D)
Loughborough, UK
1998-2010

Director of Process Chemistry
Main accountabilities are leadership and scientific development of the process
chemistry function including resource management, recruitment and staff
development. Was actively involved in setting global PR&D strategy in several key
areas including Discovery/PR&D interface and outsourcing.
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David C. Lathbury, Ph.D.
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Smithkline Beecham Pharmaceuticals
Tonbridge, UK and Philadelphia, PA 19101
1993-1998

Team Leader
Supervised a team of 6 chemists and 2 analysts working on a range of
development candidates. Work encompassed the full range of process
development, from initial route selection through scale up and tech transfer.
Lead TT activities on 2 projects into full scale production. Was also responsible
for establishing the large scale preparative HPLC facility at Tonbridge as well as
coordinating graduate and Ph.D. recruitment activities.
1991-1993
Principle Investigator
MTM Fine Chemicals
Kirkby , Liverpool, UK
1989-1991

Laboratory Head
Supervised a team of 12 chemists working on the optimisation of processes for
supplying intermediates to the pharmaceutical and agrochemical industries. The
role involved scientific leadership and staff development as well as some
commercial activities and hands-on pilot plant experience.
Shell Research
Sittingbourne, Kent, UK
1986-1989

Agrochemical Discovery and Process Development
Initial work in Herbicide discovery lead to 2 field trial candidates. Followed the
compounds into process development and devised and scaled up processes to
supply multi-kilogram amounts of both candidates.
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David C. Lathbury, Ph.D.
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Bath University
Claverton Down, Bath BA2 7AY
1984-1986

Postdoctoral Position with Professor Tim Gallagher
The synthetic applications of Amino-Allene cyclisation reactions (see publications
list).
Cornell University
Ithaca, NY 14850
1983-1984

Postdoctoral Research with Professor John McMurry
Synthetic applications of zero valent Titanium mediated,carbonyl coupling
reactions.
EDUCATION
1983
Southampton University, Southampton UK
Ph.D., Synthetic Organic Chemistry
Thesis Title: “New Methodology Using Nitrile Oxide/Alkene Cycloadditions and Synthetic Approaches to Strychnos Alkaloids.”
1980
Southampton University, Southampton UK
BSc., Chemistry
AWARDS/ ACHEIVEMENTS
Chair, Gordon Research Conference, Heterocyclic compounds, 2012
Royal Society of Chemistry Inspiration and Industry award, 2010
IchemE Hanson Medal, 2009
Hurter Memorial Lecture, 2005
Visiting Professor, Department of Chemistry, Bristol University
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David C. Lathbury, Ph.D.
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PATENTS
“Process for the Preparation of Aryl-piperidine Carbinols and Intermediates Thereof.”
Ennis, David S.; Lathbury, David C. Application WO 0228834.
“Preparation of 4-aryl-3-hydroxymethylpiperidines by Reduction of 4-amino-4-aryl-3hydroxymethylpiperidines or Isoxazolidine Derivatives.” Ennis, David S.; Lathbury, David
C. Application US 97-966993 19971110. Priority: GB 96-23359 19961109.
“Preparation of 1,1,2-triaryl-1-alkenes.” Hussain, Nigel; Morgan, David O.; Lathbury,
David C. Int. Appl. Application: WO 98-GB1990 19980707 130:124880, 1999.
“Preparation of 3-(hetero)aryl-4-acylisoxazoles as Herbicides.” Sakhalkar, Shrikant S.;
Khandekar, Girish M.; Sahasrabudhe, Suhas D.; Rao, Chennupati K.; Lathbury, David C.
Application: GB 94-22682 19941110.
“Preparation of Substituted Ethylidenefuranone Derivatives.” Lathbury, David C.; Briggs,
Stuart P. GB 89-24760 19891102.
“Preparation of Herbicidally Active Substituted Ethylidenefuranone Compounds.”
Lathbury, David C.; Day, Janet A. GB 89-24759 19891102.
“Preparation of Acylalkenoic Acid Derivatives as Herbicides.” Lathbury, David C. EP
395182 A1 19901031.
“Perennial Weeds Control with 3-(1-aminoethylidene)-5-methylfuran-2,4-dione.” Raven,
Clive A.; Jenkins, Elizabeth S.; Lathbury, David C. EP 351020 A2 19900117.
PUBLICATIONS
Lathbury,D.C. Manufacturing Chemist,2011, 47-48
Ace, K.W.; Armitage, M.A.; Bellingham, R.K.; Blackler, P.D.; Ennis, D.S.; Hussain, N.;
Lathbury, D.C.; Morgan, D.O.; O'Connor, N.; Oakes, G.H.; Passey, S.C.; Powling, L.C.
“Development of an Efficient and Stereoselective Manufacturing Route to Idoxifene,”
Org. Process Res. Dev., 2001, 5, 479–490.
Ennis, D.S.; Lathbury, D.C.; Wanders, A.; Watts, D. “Scale-up of an Intermolecular Barbier
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David C. Lathbury, Ph.D.
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Reaction,” Org. Process Res. Dev., 1998, 2, 287–289.
Bulman Page, P.C.; Purdie, M.; Lathbury, D.C. “Regioselective and stereoselective 1,3dipolar addition of nitrile oxides to 2-crotyl-1,3-dithiane 1-oxides,” Tetrahedron, 1997,
53, 1061–1080.
Bulman Page, P.C.; Purdie, M.; Lathbury, D.C. “Unusual Reversal of Stereoselectivity of
1,3-dipolar Cycloaddition in the Presence of Lewis Acids,” Tetrahedron, 1997, 53, 7365–
7370.
Simpson, A.F.; Szeto, P.; Lathbury, D.C.; Gallagher, T. “Oxazaborolidine-mediated
Reduction of Prochiral 2-alkylidenecycloalkanones,” Tetrahedron: Asymmetry, 1997, 8,
673–676.
Bulman Page, P.C.; Purdie, M.; Lathbury, D.C. “Regioselective and Stereoselective 1,3dipolar Addition of Nitrile Oxides to 2-crotyl-1,3-dithiane 1-oxides,” Tetrahedron, 1997,
53, 1061–1080.
Bulman Page, P.C.; Purdie, M.; Lathbury, D.C. “Enantioselective S
hydroxyketones using the DiTOX Asymmetric Building Block,” Tetrahedron Lett., 1996,
37, 8929–8932.
Stockman, R.A.; Szeto, P.; Thompson, S.H.J.; Hadley, M.S.; Lathbury, D.C.; Gallagher, T.
“Synthesis of Functionalized Azabicycles via a Regiospecific Intramolecular Aldol
Reaction,” School Chemistry, University Bristol, Bristol, UK; Synlett, 1996, 853–855.
Andrews, I.P.; Dorgan, R.J.J.; Harvey, T.; Hudner, J.F.; Hussain, N.; Lathbury, D.C.; Lewis,
N.J.; Macaulay, G.S.; Morgan, D.O. “A Practical Synthesis of the Milbemycin SB-201561,”
Tetrahedron Lett., 1996, 37, 4811–4814.
Ace, K.W.; Hussain, N.; Lathbury, D.C.; Morgan, D.O. “
(aminooxy)arylacetic Ester by the R
-diazo Ester with Nhydroxyphthalimide,” Tetrahedron Lett., 1995, 36, 8141–4.
Szeto, P.; Lathbury, D.C.; Gallagher, T. “Heterocyclic Ketones as Pre-formed Building
Blocks. Synthesis of (-)-slaframine,” Tetrahedron Lett., 1995, 36, 6957–60.
Armitage, M.A.; Lathbury, D.C.; Sweeney, J.B. “Preparation of 2-aryl and 2-heteroaryl
Substituted Penems by Palladium Mediated Cross Coupling,” Tetrahedron Lett., 1995,
36, 775–6.
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Armitage, M.A.; Lathbury, D.C.; Mitchell, M.B. “A General Synthesis of 2-substituted
Cyclohex-2-enones,” J. Chem. Soc., Perkin Trans., 1994, 1, 1551–2.
Shaw, R.W.; Lathbury, D.C.; Gallagher, T. “Cyanoalkyl Amines as a Source of Acyclic and
Heterocyclic Azomethine Ylides,” Synlett, 1993, 710–12.
Gallagher, T.; Davies, I.W.; Jones, S.W.; Lathbury, D.C.; Mahon, M.F.; Molloy, K.C.; Shaw,
R.W.; Vernon, P.J. “Electrophile-mediated Cyclizations Involving the A
-System.
Stereoselectivity and Synthetic Utility of Palladium(II)-catalyzed Heteroatom Cyclization
Reactions. X-ray Molecular Structure of Methyl 2-[trans-3-phenyl-N-(ptolylsulfonyl)pyrrolidin-2-yl]acrylate,” Chem. Soc., Perkin Trans. 1, 1992, 433–40.
Shaw, R.; Lathbury, D.C.; Anderson, M.; Gallagher, T. “Application of Electrophilemediated Cyclizations to the Synthesis of the Hexahydroazepine Ring System,” J. Chem.
Soc., Perkin Trans. 1, 1991, 659–60.
Huby, N.J.S.; Kinsman, R.G.; Lathbury, D.C.; Vernon, P.G.; Gallagher, T. “Synthetic and
Stereochemical Studies Directed Towards Anatoxin-a,” J. Chem. Soc., Perkin Trans. 1,
1991, 145–55.
Fox, D.N.A.; Lathbury, D.C.; Mahon, M.F.; Molloy, K.C.; Gallagher, T. “Enantioselective
Synthesis of Pumiliotoxin 251D. A Strategy Employing an Allene-based Electrophilemediated Cyclization,” J. Am. Chem. Soc., 1991, 113, 2652–6.
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Lathbury, D.C.; Shaw, R.W.; Bates, P.A.; Hursthouse, M.B.; Gallagher, T. “Electrophilemediated Cyclizations: Regioselective Synthesis of Substituted Cyclic Nitrones and Crystal
Structures of the Nitrone Cycloadducts,” J. Chem. Soc., Perkin Trans. 1, 1989, 2415–24.
Fox, D.N.A.; Lathbury, D.C.; Mahon, M.F.; Molloy, K.C.; Gallagher, T. “Asymmetric
Synthesis of Functionalized Pyrrolidines. The Role of a Stereogenic Center on Nitrogen,”
J. Chem. Soc., Chem. Commun., 1989, 1073–5.
Lathbury, D.C.; Parsons, P.J.; Pinto, I. “A Route to the Pyrrolizidine ring System using a
Novel Radical Cyclization,” Highfield/Southampton, UK, J. Chem. Soc., Chem. Commun.,
1988, 81–2.
Kinsman, R.; Lathbury, D.C.; Vernon, P.; Gallagher, T. “Stereoselectivity in the Synthesis
of 2,5-disubstituted Pyrrolidines,” J. Chem. Soc., Chem. Commun., 1987, 243–4.
Lathbury, D.C.; Vernon, P.; Gallagher, T. “Palladium(II)-mediated Routes to
Functionalized Heterocycles,” Tetrahedron Lett., 1986, 27, 6009–12.
Lathbury, D.C.; Gallagher, T. “Stereoselective Synthesis of Pyrrolizidine Alkaloids via
Substituted Nitrones,” J. Chem. Soc., Chem. Commun., 1986, 1017–18.
Lathbury, D.C.; Gallagher, T. “Asymmetric Synthesis via Allenes: Synthesis of (R)-(-)coniine,” J. Chem. Soc., Chem. Commun., 1986, 114–15.
Lathbury, D.C.; Gallagher, T. “A New Approach to Cyclic nitrones: Application to the
Synthesis of 1,2'-disubstituted Piperidines and Pyrrolidines,” Sch. Chem., Tetrahedron
Lett., 1985, 26, 6249–52.
Lathbury, D.C.; Parsons, P. “Studies on the Addition of Nitrile Oxides to 1-(phenylthio)1,3-butadiene, A New Directed Aldol Condensation,” J. Chem. Soc., Chem. Commun.,
1982, 291–2.