Supporting information
Controlling the size and morphology of Griseofulvin nanoparticles using polymeric
stabilizers by evaporation assisted solvent-antisolvent interaction method
Raj Kumar and Prem Felix Siril*
School of Basic Sciences and Advanced Material Research Centre, Indian Institute of Technology Mandi, Mandi175005, Himachal Pradesh, India.
*
Corresponding author: Dr. Prem Felix Siril
Postal Address:
Dr. Prem Felix Siril, School of Basic Sciences, Indian Institute of Technology Mandi, Mandi- 175001, India
Telephone: +91-9418018620, Fax: +91-1905-237942
Email Addresses: (Dr. Prem Felix Siril*) prem@iitmandi.ac.in; (Raj Kumar) rk7410@gmail.com.
Figure S1 (a) & (b) TEM images of GF-PVP nanoparticles
Figure S2 (a) & (b) TEM images of GF-HPMC nanoparticles
Figure S3 FTIR spectra of prepared nanosized GF-HPMC, GF-PVP, micro-GF and raw-GF
Figure S4 XRD patterns of prepared nanosized GF-HPMC, GF-PVP, micro-GF and raw-GF
Figure S5 DSC thermal curves of prepared nanosized GF-HPMC, GF-PVP, micro-GF and raw-GF
Table T1 Properties of Griseofulvin particles with particle size below 1000 nm
S. No
Methods
Particle size
/ nm
Dissolution
rate
1
Emulsion solvent diffusion
(Dandagi et al., 2011)
628
98 % in 120
min
200-500
80% in
90min
390-523
100% in 120
min
85
85% in 1
min
145
97 % in 2
min
130
-
50-250
-
220
-
2
3
4
5
6
7
8
9
10
Rapid expansion of
supercritical solutions
(Türk et al., 2002)
Nanoprecipitation
(Zili et al., 2005)
solvent diffusion technique
(Trotta et al., 2003)
wet media milling followed
by fluidized bed coating
(Bhakay et al., 2013)
supercritical CO2
antisolvent with enhanced
mass transfer
(Chattopadhyay and Gupta,
2001)
Rapid expansion of
supercritical solution with
solid cosolvent
(Thakur and Gupta, 2006)
freeze-drying
(Doktorovova et al., 2013)
liquid antisolvent (LAS)
process (Beck et al., 2013)
EASAI method
(present work)
0.58
28±9
87 % in 60
min
98 % in 60
min
Dissolution conditions
900 ml 4% SLS solution as dissolution
medium preheated and maintained at
37 + 0.50C and 75 rpm
100 ml of an artificial gutfluid, (pH
7.4) and 3 mg Griseofulvin.
distilled water of 1000 ml The samples
were incubated at 25 ºC at 500 rpm
250 ml water to maintain sink
conditions and incubated at 37 ◦C
under gentle magnetic stirring at 300
rpm
900 ml, 0.27% solution of SDS, 37 °C
and a paddle speed of 50 rpm
Flow through cell dissolution
apparatus
0.27% solution of SDS,900 ml, 37 °C
and a stirror speed of 100 rpm
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