1.
Basic information
Name: Ruei-Ming Chen
(陳瑞明
)
Address: Graduate Institute of Medical Sciences
College of Medicine, Taipei Medical University
No. 250, Wu-Hsing Street
Taipei 110, Taiwan.
TEL: 27361661 ext 3222
Fax: 886-2-86621119
E-mail: rmchen@tmu.edu.tw
, rmchen@wanfang.gov.tw
Ph.D. (1994-1998)
Institute of Toxicology
College of Medicine
National Taiwan University, Taipei, Taiwan.
2.
Current position and professional experience
Associate Professor (2003 - present)
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical
University
Associate Professor (2002 - 2003)
School of Medicine, College of Medicine, Taipei Medical University
Assistant Professor (1999 – 2002)
School of Medicine, College of Medicine, Taipei Medical University
Assistant Professor (1999 – 1999)
Department of Medical Technology, Chung-Tai Institute of Health Sciences and Technology, Taichung, Taiwan
Post-doctor (1998-1999)
School of Medicine, College of Medicine, National Taiwan University,
Taipei, Taiwan
Visitor Scholarship (1996-1996)
Department of Biochemistry, National Center of Toxicology Research,
Jefferson, Little Rock, Arkansas, USA
3.
Fields of specialty
Drug Metabolism, Cell physiology
4.
Representative publication
(A)
期刊論文
1.
Chen RM and Ueng TH (1997) Induction of cytochrome P450 1A, 2B and 2E in hamster tissues by acetone. Arch Toxicol 71 (8): 489-495. (SCI)

2.
Ueng TH, Hwang WP, Chen RM , Wang HW and Kuo ML (1998) Effects of motorcycle exhaust on cytochrome P450-dependent monooxygenase and glutathione S-transferase in rat tissues. J Toxicol Environ Health 54 (7): 509-527.
(SCI)
3.
Chen RM , Chou MW and Ueng TH (1998) Induction of cytochrome P450 1A in hamster liver and lung by 6-nitrochrysene. Arch Toxicol 72 (7): 395-401. (SCI)
4.
Liu HC, Chen RM (Corresponding author) Lin FH and Fang HW (1999).
Sintered

-dicalcium phosphate particles induce intracellular reactive oxygen species in rat osteoblasts. Biomed Eng Appl Basis Comm 11 (5): 259-264.
5.
Chen RM , Chou MW and Ueng TH (2000) Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene. Toxicol Lett 117 (2000):
69-77. (SCI)
6.
Ueng, TH, Hu SH, Chen RM , Wan HW and Kuo ML (2000) Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells and lung carcinoma
NCI-H322 cells by motorcycle exhaust particulate. J Toxicol Environ Health
60(2):101-119. (SCI)
7.
Chen TL, Chen TG, Tai YT, Chang HC, Chen RM , Lin CJ and Ueng TH (2000).
Propofol inhibits renal cytochrome P450 activity and enflurane defluorination in vitro in hamsters. Can J Anaesth 47: 680-686. (SCI)
8.
Chen TL, Chang HC, Chen TG, Tai YT and Chen RM (2000). Modulation of cytochrome P450-dependent monooxygenases in streptozotocin-induced diabetic hamster: I. Effects of propofol on defluorination and cytochrome P450 activities.
Acta Anaesthesiol Sin 38: 15-21.
9.
Chen TG, Tai YT, Chang HC, Hong CT, Chen RM and Chen TL (2000).
Modulation of cytochrome P450-dependent monooxygenases in streptozotocin-induced diabetic hamster: II. Reverse role of insulin in P450 activities and defluorination. Acta Anaesthesiol Sin 38: 65-72.
10.
Tai YT, Wu CC, Wu GJ, Chang HC, Chen TG, Chen RM and Chen TL (2000).
Study of propofol in bovine aortic endothelium: I. Inhibitory effects on bradykinin-induced intracellular calcium immobilization. Acta Anaesthesiol Sin 38:
181-186.
11.
Liu HC, Chen RM (Corresponding author) , Jian WC and Lin YL (2001)
Cytotoxic and Antioxidant Effects of the Water Extract of Traditional Chinese
Herb Gusuibu ( Drynaria fortunei) on Rat Osteoblasts. J Formos Med Assoc 100
(6): 1-6 (SCI)
12.
Lin JH, Lin YT, Huang YJ, Wen KC, Chen RM , Ueng TH and Liao CH (2001)
Isolation and cytotoxicity of flavonoids from Daphnis Genkwae Flos. J Food Drug
Anal 9 (1): 6-11.

13.
Chang HC, Tsai SY, Wu GJ, Lin YH, Chen RM and Chen TL (2001) Effects of propofol on mitochondrial function and intracellular cacium shift in bovine aortic endothelial model. Acta Anaesthesiol Sin 39: 115-122.
14.
Chen RM , Lin YL, Jean WC, Chen JS, Wang JH and Liu HC (2002) Nitric oxide induces osteoblast apoptosis through the de novol synthesis of Bax protein. J
Orthopaed Res 20 (2): 295-302. (SCI)
15.
Chang H, Tsai SY, Chen TL and Chen RM (Corresponding author) (2002)
Therapeutic concentrations of propofol protects mouse macrophages from nitric oxide-induced cell death and apoptosis. Can J Anesth 49: 477-480. (SCI)
16.
Wu CH, Chen TL, Chen TG, Ho WP, Chiu WT, and Chen RM (Corresponding
author) (2003) Nitric oxide modulates pro- and anti-inflammatory cytokines in lipopolysaccharide-activated macrophages. J Trauma 55; 540-545 (SCI)
17.
Chen RM , Wu CH, Chang HC, Lin YL, Sheu JR and Chen TL (2003) Propofol suppresses macrophage functions through modulating mitochondrial membrane potential and cellular adenosine triphosphate levels. Anesthesiology 98: 1178-85.
(SCI)
18.
Chen RM , Wu GJ, Tai YT, Lin YL, Jean WC and Chen TL (2003) Propofol downregulates nitric oxide biosynthesis through inhibiting inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Arch Toxicol 77: 418-23.
(SCI)
19.
Chen JT, Chen RM , Lin YL, Chang HC, Lin YH, Chen TL and Chen TG (2004)
Confocal laser scanning microscopy: I. an overview of principle and practice in biomedical research. Acta Anaesthesiol Sin 42: 33-40.
20.
Ueng YF and Chen RM (2004) The role of cytochrome P450 in herb-drug interactions. Current pharmacogenetics 2: 83-112.
21.
Chen RM , Chen TL, Lin LL, Chang CC, Chang HC and Wu CH. (2004)
Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages. Annals New York Acad Sci (accepted).
(SCI)
22.
Wu GJ, Tai YT, Chen TL, Lin LL and Chen RM (corresponding author)
(2004) Propofol specifically inhibits mitochondrial membrane potential but not complex I nadh dehydrogenase activity thus reducing cellular atp biosynthesis and migration of macrophages. Annals New York Acad Sci (accepted). (SCI)
23.
Chen RM (corresponding author) , Chen TL, Chiu WT and Chang CC (2004)
Molecular mechanism of nitric oxide-induced osteoblast apoptosis. J Orthopaed
Res (in press) (SCI)
24.
Ho WP, Chen TL, Chiu WT, Tai YT, and Chen RM (corresponding author)
(2004) Nitric oxide induced osteoblast apoptosis through a

mitochondrial-dependent pathway. Annals New York Acad Sci (accepted). (SCI)
25.
Chen RM , Wu GJ, Chang HC, Chen JT, Chen TF, Lin YL and Chen TL (2004)
2,6-Diisopropylphenol protects osteoblasts from oxidative stress-induced apoptosis through suppression of caspase-3 activation. Annals New York Acad Sci (accepted).
(SCI)
26.
Chen RM (corresponding author) , Chen TL, Lin YL, Chen TG, Tai YT.
(2004). Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells through downregulating endothelial nitric oxide synthase expression and intracellular calcium levels. Crit Care Med (accepted). (SCI)
27.
Chang Y, Chen TL, Chiu WT, Chen RM (corresponding author) . (2004).
Suppressive effects of ketamine on macrophage functions. Toxicol Appl Pharmacol
(accepted). (SCI)
28.
Ueng YF, Tsai TH, Don MJ, Chen RM , Chen TL(2004). Alternation of the pharmacokinetics of theophyline by rutaecarpine, an alkaloid of the medical herb
Evodia rutaecarpa, in rats. J Pharm Pharmacol (in press). (SCI)
29.
Chen RM , Chen TL, Chiu WT and Lin YL (2004) Biphasic effects of nitric oxide on chondrocyte activities. J Orthopaed Res (in press) (SCI)
(B)
研討會論文
1.
Chen RM and Ueng TH (1993) Differential effects of acetone administration on cytochrome P450-dependent monooxygenases in hamster tissues. The Ninth
Joint Annual Conference of Biomedical Science. Abstract 159, p30.
2.
Chen RM and Ueng TH (1996) Evidence that acetone increases cytochrome
P450 1A, 2B and 2E mRNA levels in hamster tissues. The Eleventh Joint Annual
Conference of Biomedical Science. Abstract 111, p108.
3.
Ueng TH, Hwang WP, Wang HW and Chen RM (1997) Effects of motorcycle emission particles on cytochrome P450-dependent monooxygenases in rat. The
Twelfth Joint Annual Conference of Biomedical Science. Poster 153, p235.
4.
Chen RM , Hwang WP, Wang HW, Kuo ML and Ueng TH (1998) Effects of motorcycle exhaust on cytochrome P450-dependent monooxygenases and glutathione S-transferase in rat tissues. The Thirteenth Joint Annual Conference of
Biomedical Science. Abstract 28.
5.
Liu HC, Chen RM and Wang CH (1999) Nitric oxide induces apoptosis of rat osteoblast-like cells. The Ninth Sino-Japanese Orthopaedic Symposium.
6.
Liu HC, Lin FH and Chen RM (Corresponding author) (1999) Sintered beta-dicalcium phosphate particles increase oxidative stress of rat osteoblasts-a

possible mechanism of osteolysis. The Orthopaedic Research Society, ROC, 1999 annual meeting.
7.
Chen RM and Liu HC (2000) Nitric oxide induced apoptosis of rat osteoblast through induction of Bax protein. The 46 th
Annual Meeting of Orthopaedic
Research Society, Orlando, Florida, USA.
8.
Liu HC and Chen RM (2000)
傳統骨科中藥材骨碎補對骨細胞之生理活性
研究 行政院衛生署中醫藥委員會中醫藥研究成果發表會
2000,
台北醫學院
,
台北
,
中華民國
9.
Chen RM , Liu HC, Lin YL and Jean WC (2001) Modulations of intracellular oxidative stress, mitochondrial membrane potential and Bcl-2/Bax proteins are involved in NO-induced osteoblast apoptosis. The 47 th
Annual Meeting of
Orthopaedic Research Society, San Francisco, California, USA.
10.
Chen RM , Liu HC, Ho WP and Chen TL (2001) Nitric oxide protects human osteoblast-like MG63 cells from oxidative stress-induced cell apoptosis through suppression of Bax protein. The 47 th
Annual Meeting of Orthopaedic Research
Society, San Francisco, California, USA.
11.
Chen RM , Wu CH and Chen TL (2001) Effects of nitric oxide on modulating productions of pre- and anti-inflammatory cytokines.
中華民國外科醫學會第六
十次學術演講大會.
12.
Chen RM , Liu HC, Wu CH and Jean WC (2001) Nitric oxide induces osteoblast apoptosis through the de novo synthesis of bax protein. The Sixteenth
Joint Annual Conference of Biomedical Science. Poster 331.
13.
Chen RM , Ho WP and Chen TL (2001) Protective effects of nitric oxide on oxidative stress-induced cell apoptosis. The Sixteenth Joint Annual Conference of
Biomedical Science. Poster 332.
14.
Chen RM , Wu CH, Lin YL and Chen TL (2001) Protective role of propofol to cellular damages induced by nitric oxide. The Sixteenth Joint Annual Conference of Biomedical Science. Poster 333.
15.
Chen RM and Liu HC (2001) Induction of intracellular reactive oxygen species in rat osteoblasts exposed to sintered beta-dicalcium phosphate particles. Fourth
Combined Meeting of the Orthopaedic Research Societies of the USA, Canada,
Europe and Japan. Rhodes, Greece. (June 1-3, 2001)
16.
Liu HC and Chen RM (2001)
傳統骨科中藥材骨碎補臨床療效研究 行政院

衛生署中醫藥委員會中醫藥研究成果發表會
2001,
國防醫學院
,
台北
,
中華
民國
17.
Chen RM , Wu CH, Chen TL and Chiu WT (2002) Modulating effects of nitric oxide on endotoxin lipopolysaccharide-induced tnf-

, il-1

and il-10 in macrophages.
中華民國外科醫學會第六十一次學術演講大會
18.
Chen RM , Chiu WT, Chen TL, Chen SY, Lin JW and Chiang PY (2002)
Expression of the proto-oncogene c-jun in human meningiomas
中華民國外科醫
學會第六十一次學術演講大會
19.
Chen RM , Chen TL, Lin YL, Ho WP, and Liao YS (2002) Role of cytochrome c in nitric oxide-induced osteoblast apoptosis. The Seventeenth Joint Annual
Conference of Biomedical Science. Poster 407.
20.
Chen RM , Lin YL, Jean WC, Chen TG, Tai YT, Chang HC and Chen TL (2002)
Propofol protects macrophages from nitric oxide–induced apoptosis. The
Seventeenth Joint Annual Conference of Biomedical Science. Poster 420.
21.
Liu HC and Chen RM (2002)
傳統骨科中藥材骨碎補臨床療效研究
(I)
行
政院衛生署中醫藥委員會中醫藥研究成果發表會
2002,
中醫醫學大學
,
台中
,
中華民國
22.
Chen RM , Ho WP, Liao YS, Lin YH, Lin YL and Chen TL (2002) Nitric oxide induced osteoblast apoptosis is involved by cellular oxidative stress, mitochondrial membrane potential and bcl-2 protein. 91
年中華民國骨科醫學會學術研討會
23.
Chen RM , Chen JT, Chang HC, Chen TG, Tai YT, and Chen TL (2002)
Propofol suppresses macrophage functions through modulating mitochondrial membrane potential and cellular adenosine triphosphate levels. 91
年中華民國麻
醉醫學會會員大會暨第四十六屆學術研討會
24.
Chen RM , Liu HC, Ho WP, Lin YL, Liao YS, Huang JY, and Chen TL (2003)
Nitric oxide induced osteoblast apoptosis is involved by the modulation of intracellular calcium concentrations and caspase-3 activity. The 49 th
Annual

Meeting of Orthopaedic Research Society, New Orlean, Miss, USA.
25.
Chen RM , Liu HC, Jean WC, Lin YL, Lin YW and Chen TL (2003)
Cytochrome c is involved in no-induced osteoblast apoptosis. The 49 th
Annual
Meeting of Orthopaedic Research Society, New Orlean, Miss, USA.
26.
Liu HC and Chen RM (2003)
傳統骨科中藥材骨碎補臨床療效研究
(II)
行
政院衛生署中醫藥委員會中醫藥研究成果發表會
,
中國醫學大學
,
台中
,
中華
民國
27.
Chen RM , Chen JT, Tai YT, Chang HC, Chen TG and Chen TL (2003)
Propofol reduces nitric oxide biosynthesis in lipopolysaccharide-activated macrophages by downregulating the expression of inducible nitric oxide synthase.
92
年中華民國麻醉醫學會會員大會暨第四十七屆學術研討會
28.
Chen RM , Chen JT, Chang HC, Chen TG, Tai YT and Chen TL (2003)
Propofol suppresses macrophage functions through modulating mitochondrial membrane potential and cellular adenosine triphosphate levels. The Eighteenth
Joint Annual Conference of Biomedical Science, Taipei, Taiwan
29.
Chen RM , Liu HC, Ho WP, Lin YL, Liao YS, Huang JY and Chen TL (2003)
Nitric oxide induced osteoblast apoptosis is involved by the modulation of intracellular calcium concentrations and caspase-3 activity. The Eighteenth Joint
Annual Conference of Biomedical Science, Taipei, Taiwan
30.
Chen RM , Ho WP, Chang CC, Huang JY, Lin YL, Chen TL (2004) Nitric oxide-induced osteoblast apoptosis is involved by the mitochondria-dependent caspase activation. The 50 th
Annual Meeting of Orthopaedic Research Society, San
Francisco, Ca, USA.
31.
Chen RM , Chen TL and Liao CY. (2004) Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells through downregulating endothelial nitric oxide synthase expression and intracellular calcium levels. The
Nineteenth Joint Annual Conference of Biomedical Science, Taipei, Taiwan.
32.
Chen JT, Chen TL and Chen RM . (2004) Effects of intravenous anesthetic agents on endothelin-1 and cox-1 expression in human umbilical vein endothelial cells. The Nineteenth Joint Annual Conference of Biomedical Science, Taipei,
Taiwan.
33.
Wang, HC, Chen TF, Chen TL and Chen RM . (2004) Regulatory effects of
2,6-diisopropylphenol on the cytoskeleton of hepatocytes, macrophages and endothelial cells.

34.
Lin YL, Chen TL and Chen RM . (2004) CYP2B1/2 contributes to propofol metabolism to 4-hydroxy-propofol in rat liver. The Nineteenth Joint Annual
Conference of Biomedical Science, Taipei, Taiwan.
35.
Chen RM , Wu GJ, Chang HC, Chen JT, Chen TF, Lin YL and Chen TL (2004)
2,6-Diisopropylphenol protects osteoblasts from oxidative stress-induced apoptosis through suppression of caspase-3 activation. The 2 nd
Conference of Asian Society for Mitochondrial Research and Medicine. Taipei, Taiwan.
36.
Chen RM , Ho WP, Chen TL, Chiu WT and Tai YT (2004) Nitric oxide induced osteoblast apoptosis through a mitochondrial-dependent pathway.The 2 nd
Conference of Asian Society for Mitochondrial Research and Medicine. Taipei,
Taiwan.
37.
Chen RM , Wu GJ, Tai YT, Chen TL and Lin LL (2004) Propofol specifically inhibits mitochondrial membrane potential but not complex I nadh dehydrogenase activity thus reducing cellular atp biosynthesis and migration of macrophages.The
2 nd
Conference of Asian Society for Mitochondrial Research and Medicine. Taipei,
Taiwan.
38.
Chen RM , Chen TL, Lin LL, Chang CC, Chang HC and Wu CH. (2004)
Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages. The 2 nd
Conference of Asian Society for Mitochondrial Research and Medicine. Taipei, Taiwan.
39.
Chen RM , Chen TL, Chiu WT and Lin YL (2004) Biphasic effects of nitric oxide on chondrocyte activities. The 5 th
combined meeting of ORS, USA, Canada,
Europe, and Japan. Banff, Alberta, Canada.
5. List of projects currently or previously executed in last three years
2002/08 – 2003/07 NSC, NSC91-2314-B-038-027, In vitro and in vivo studies on the anti-inflammatory effects of 2,6-diisopropylphenol.
NT983,000.
2002/08 – 2003/07 NSC, NSC91-2314-B-038-031, Study on nitric oxide-induced osteoblast apoptosis. the role of caspases. (1/2). NT762,000.
2002/08 – 2003/07 NSC, NSC91-2321-B-002-005, Tissue Engineering of cartilage.
(1/3). NT10,000,000
2003/07 – 2004/08 NSC, NSC92-2314-B-038-045, Evaluation of the roles of toll-like receptors-mediated signal transduction pathway in propofol-involved anti-oxidative and anti-inflammatory effects.
NT930,000
2003/07 – 2004/08 NSC, NSC92-2314-B-038-010, Study on nitric oxide-induced osteoblast apoptosis. the role of caspases. (2/2). NT882,000.
2003/07 – 2004/08 NSC, NSC92-2321-B-002, Tissue Engineering of cartilage. (2/3).

NT10,000,000.
2004/07 – 2005/08 NSC, NSC93-2745-B-038-002-URD, Molecular mechanism of
LOX-1 gene regulation by oxidized LDL in cerebral endothelial cells. (1/3). NT1,500,000.
2004/07 – 2005/08 NSC, NSC93-2314-B-341-006, Molecular mechanism of anti-inflammatory and anti-oxidative effects of intravenous anesthetic agent propofol on lipopolysaccharide-activated macrophages. NT759,000.
2004/07 – 2005/08 NSC, NSC93-2321-B-341-006, Tissue Engineering of cartilage.
(3/3). NT10,000,000.
2005/01 – 2005/12 DOH, DOH94-TD-M-113-043 Immunoregulatory effects of ketamine on macrophage functions and its possible mechanism.
NT960,000.
2005/01 – 2005/12 SKH-TMU, SKH-TMU-94-04, Suppression of ketamine, an intravenous anesthetic agent, on macrophage activities.
NT700,000.